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Jean-Nicolas Vauthey, MD

Present Title & Affiliation

Primary Appointment

Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Chief, Hepato-Pancreato-Biliary Section, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Bessie McGoldrick Professor in Clinical Cancer Research, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Vauthey’s clinical research focuses on methods to measure and to improve outcome after hepatic resection for hepatobiliary malignancies. Dr. Vauthey proposed a standardized method for calculating the volume of the anticipated liver remnant prior to liver surgery. This method of measurement is used to compare patients prior to liver resection to determine the need for preoperative portal vein embolization. Dr. Vauthey critically analyzed the staging system for hepatocellular carcinoma and based on his work, the American Joint Committee on Cancer and the International Union Against Cancer adopted a new simplified staging systems for hepatocellular carcinoma. Dr. Vauthey is Chair of The American Joint Committee on Cancer Hepatobiliary Task Force for the 7th Edition of the Manual for Staging Cancer. Dr. Vauthey has evaluated the use of preoperative chemotherapy in the multidisciplinary treatment of patients with hepatic colorectal metastases. He is the author of a treatment algorithm for hepatic colorectal liver metastases.


Dr. Vauthey organized and chaired symposia at national and international meetings. Dr. Vauthey is the past President of the Americas Hepato-Pancreato-Biliary Association. Dr Vauthey is on the Board of Trustees of the Society for Surgery of the Alimentary Tract. Dr. Vauthey co-authored more than 400 publications in peer-reviewed journals and more than 85 reviews and book chapters in major textbooks. Dr. Vauthey is editor of major textbooks devoted to hepatobiliary cancers.  Dr. Vauthey is on the editorial board of the Journal of the American College of Surgeons, Surgery, Annals of Surgery, Annals of Surgical Oncology and the Journal of Gastrointestinal Surgery.


 Dr. Vauthey is the recipient of the prestigious 2011 Faculty Achievement Award in Patient Care for his commitment to the mission of The University of Texas MD Anderson Cancer.

Education & Training

Degree-Granting Education

1983 Lausanne University Medical School, Lausanne, Switzerland, MD, Medical Doctor Thesis
1979 Lausanne University Medical School, Lausanne, Switzerland, MD, Swiss Federal Medical Diploma
1973 Gymnase of Vevey, Vevey, Switzerland, BA, Physics and Biology

Board Certifications

11/1990 American Board of Surgery, Recertification Date: 12/2008


Other Appointments/Responsibilities

Chair, Hepatobiliary Expert Panel, AJCC Cancer Staging Manual 8th Edition, Chicago, IL, 8/2013-present

Institutional Committee Activities

Co-Chair, Cholangiocarcinoma Institutional Working Group, 1/2013-present

Honors and Awards

2012 Cancer Fighters' Eagle Award, Cancer Fighters of Houston, Inc.
2011 Apple Award, MD Anderson Patient Education Office and the Health Education Week 2011 Committee
2011 Faculty Achievement Award in Patient Care, The University of Texas MD Anderson Cancer Center

Selected Publications

Peer-Reviewed Original Research Articles

1. Passot G, Chun YS, Kopetz SE, Zorzi D, Brudvik KW, Kim BJ, Conrad C, Aloia TA, Vauthey JN. Predictors of safety and efficacy of 2-Stage hepatectomy for bilateral colorectal liver metastases. J Am Coll Surg 223(1):99-109, 7/2016. PMID: 26968325.
2. Ribero D, Zimmitti G, Aloia TA, Shindoh J, Forchino F, Amisano M, Passot G, Ferrero A, Vauthey JN. Preoperative cholangitis and future liver remnant volume determine the risk of liver failure in patients undergoing resection for hilar cholangiocarcinoma. J Am Coll Surg 223(1):87-97, 7/2016. e-Pub 2/13/2016. PMCID: PMC4925184.
3. Mise Y, Passot G, Wang X, Chen HC, Brudvik KW, Aloia TA, Conrad C, Huang SY, Vauthey JN. A nomogram to predict hypertrophy of liver segments 2 and 3 after right portal vein embolization. J Gastrointest Surg. e-Pub 4/2016. PMID: 27073080.
4. Brudvik KW, Mise Y, Chung MH, Chun YS, Kopetz SE, Passot G, Conrad C, Maru DM, Aloia TA, Vauthey JN. RAS mutation predicts positive resection margins and narrower resection margins in patients undergoing resection of colorectal liver metastases. Ann Surg Oncol. e-Pub 3/25/2016. PMID: 27016292.
5. Torzilli G, Donadon M, Belghiti J, Kokudo N, Takayama T, Ferrero A, Nuzzo G, Vauthey JN, Choti MA, De Santibanes E, Makuuchi M. Predicting individual survival after hepatectomy for hepatocellular carcinoma: a novel nomogram from the "HCC East & West Study Group". J Gastrointest Surg. e-Pub 3/2016. PMID: 27003271.
6. Brudvik KW, Passot G, Vauthey JN. Colorectal liver metastases: a changing treatment landscape. J Oncol Pract 12(1):40-1, 1/2016. PMID: 26759465.
7. Passot G, Odisio BC, Zorzi D, Mahvash A, Gupta S, Wallace MJ, Kim BJ, Yamashita S, Conrad C, Aloia TA, Vauthey JN, Chun YS. Eradication of missing liver metastases after fiducial placement. J Gastrointest Surg. e-Pub 1/2016. PMID: 26791387.
8. Ismael HN, Loyer E, Kaur H, Conrad C, Vauthey JN, Aloia T. Evaluating the clinical applicability of the European staging system for perihilar cholangiocarcinoma. J Gastrointest Surg. e-Pub 1/2016. PMID: 26801328.
9. Mise Y, Vauthey JN, Zimmitti G, Parker NH, Conrad C, Aloia TA, Lee JE, Fleming JB, Katz MH. Ninety-day postoperative mortality is a legitimate measure of hepatopancreatobiliary surgical quality. Ann Surg 262(6):1071-1078, 12/2015. PMID: 25590497.
10. Brudvik KW, Kopetz SE, Li L, Conrad C, Aloia TA, Vauthey JN. Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases. Br J Surg 102(10):1175-1183, 9/2015. PMID: 26206254.
11. Mansour JC, Aloia TA, Crane CH, Heimbach JK, Nagino M, Vauthey JN. Hilar Cholangiocarcinoma: expert consensus statement. HPB (Oxford) 17(8):691-699, 8/2015. PMCID: PMC4527854.
12. Shindoh J, Tzeng CW, Aloia TA, Curley SA, Huang SY, Mahvash A, Gupta S, Wallace MJ, Vauthey JN. Safety and efficacy of portal vein embolization before planned major or extended hepatectomy: an institutional experience of 358 patients. J Gastrointest Surg 18(1):45-51, 1/2014. e-Pub 10/16/2013. PMID: 24129824.
13. Tzeng CW, Tran Cao HS, Lee JE, Pisters PW, Varadhachary GR, Wolff RA, Abbruzzese JL, Crane CH, Evans DB, Wang H, Abbott DE, Vauthey JN, Aloia TA, Fleming JB, Katz MH. Treatment sequencing for resectable pancreatic cancer: influence of early metastases and surgical complications on multimodality therapy completion and survival. J Gastrointest Surg 18(1):16-24, 1/2014. e-Pub 11/16/2013. PMID: 24241967.
14. Adams RB, Aloia TA, Loyer E, Pawlik TM, Taouli B, Vauthey JN, Americas Hepato-Pancreato-Biliary Association, Society of Surgical Oncology, Society for Surgery of the Alimentary Tract. Selection for hepatic resection of colorectal liver metastases: expert consensus statement. HPB (Oxford) 15(2):91-103, 2/2013. PMCID: PMC3719914.
15. Shindoh J, Kaseb A, Vauthey JN. Surgical strategy for liver cancers in the era of effective chemotherapy. Liver Cancer 2(1):47-54, 1/2013. PMCID: PMC3747536.
16. Brouquet A, Andreou A, Shindoh J, Vauthey JN. Methods to improve resectability of hepatocellular carcinoma. Recent Results Cancer Res 190:57-67, 2013. PMID: 22941013.
17. Shindoh J, D Tzeng CW, Vauthey JN. Portal vein embolization for hepatocellular carcinoma. Liver Cancer 1(3):159-167, 11/2012. PMCID: PMC3760463.
18. Andreou A, Kopetz S, Maru DM, Chen SS, Zimmitti G, Brouquet A, Shindoh J, Curley SA, Garrett C, Overman MJ, Aloia TA, Vauthey JN. Adjuvant chemotherapy with FOLFOX for primary colorectal cancer is associated with increased somatic gene mutations and inferior survival in patients undergoing hepatectomy for metachronous liver metastases. Ann Surg 256(4):642-650, 10/2012. PMCID: PMC3856177.
19. Jones RP, Vauthey JN, Adam R, Rees M, Berry D, Jackson R, Grimes N, Fenwick SW, Poston GJ, Malik HZ. Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br J Surg 99(9):1283-1289, 9/2012. e-Pub 8/2012.
20. Glazer ES, Liu P, Abdalla EK, Vauthey JN, Curley SA. Neither neoadjuvant nor adjuvant therapy increases survival after biliary tract cancer resection with wide negative margins. J Gastrointest Surg 16(9):1666-1671, 9/2012. e-Pub 7/10/2012. PMCID: PMC3867946.
21. Truty MJ, Thomas RM, Katz MH, Vauthey JN, Crane C, Varadhachary GR, Wolff RA, Abbruzzese JL, Lee JE, Fleming JB. Multimodality therapy offers a chance for cure in patients with pancreatic adenocarcinoma deemed unresectable at first operative exploration. J Am Coll Surg 215(1):41-52, 7/2012. e-Pub 5/18/2012. PMCID: PMC4086164.
22. Tzeng CW, Fleming JB, Lee JE, Xiao L, Pisters PW, Vauthey JN, Abdalla EK, Wolff RA, Varadhachary GR, Fogelman DR, Crane CH, Balachandran A, Katz MH. Defined clinical classifications are associated with outcome of patients with anatomically resectable pancreatic adenocarcinoma treated with neoadjuvant therapy. Ann Surg Oncol 19(6):2045-2053, 6/2012. e-Pub 1/19/2012. PMID: 22258816.
23. Tzeng CW, Fleming JB, Lee JE, Wang X, Pisters PW, Vauthey JN, Varadhachary G, Wolff RA, Katz MH. Yield of clinical and radiographic surveillance in patients with resected pancreatic adenocarcinoma following multimodal therapy. HPB (Oxford) 14(6):365-72, 6/2012. e-Pub 2/2012. PMCID: PMC3384860.
24. Brouquet A, Andreou A, Vauthey JN. The management of solitary colorectal liver metastases. Surgeon 9(5):265-272, 10/2011. e-Pub 2/3/2011. PMID: 21843821.
25. Brouquet A, Vauthey JN, Contreras CM, Walsh GL, Vaporciyan AA, Swisher SG, Curley SA, Mehran RJ, Abdalla EK. Improved survival after resection of liver and lung colorectal metastases compared with liver-only metastases: a study of 112 patients with limited lung metastatic disease. J Am Coll Surg 213(1):62-9; discussion 69-71, 7/2011. PMID: 21700179.
26. Andreou A, Aloia TA, Brouquet A, Vauthey JN. Recent advances in the curative treatment of colorectal liver metastases. Gastrointest Cancer Res 4(4 Suppl 1):S2-8, 7/2011. PMCID: PMC3283006.
27. Vauthey JN, Dixon E, Abdalla EK, Helton WS, Pawlik TM, Taouli B, Brouquet A, Adams RB. Pretreatment assessment of hepatocellular carcinoma: expert consensus statement. HPB (Oxford) 12(5):289-299, 6/2010.
28. Truty, MJ, Vauthey JN. Surgical resection of high-risk hepatocellular carcinoma: patient selection, preoperative considerations, and operative technique. Ann Surg Oncol 17(5):1219-1225, 4/2010.
29. Kishi Y, Kopetz S, Chun YS, Palavecino M, Abdalla EK, Vauthey JN. Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 16(3):614-622, 3/2009. e-Pub 1/8/2009. PMID: 19130139.
30. Chun YS, Laurent A, Maru D, Vauthey JN. Management of chemotherapy-associated hepatotoxicity in colorectal liver metastases. Lancet Oncol 10(3):278-286, 3/2009. PMID: 19261256.
31. Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, Xiong HQ, Eng C, Lauwers GY, Mino-Kenudson M, Risio M, Muratore A, Capussotti L, Curley SA, Abdalla EK. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 24:2065-72, 5/2006. PMID: 16648507.
32. Vauthey JN, Zorzi D, Pawlik TM. Making unresectable hepatic colorectal metastases resectable--does it work? Semin Oncol 32(6 Suppl 9):S118-22, 12/2005. PMID: 16399448.

Invited Articles

1. Passot G, Vauthey JN. In favor of two-stage hepatectomy (TSH). Eur J Surg Oncol. e-Pub 9/2015. PMID: 26409952.
2. Brudvik KW, Vauthey JN. Peeling off technique or bile duct resection of tumor thrombus in hepatocellular carcinoma. Does future liver directed treatment justify less extensive surgery? Ann Surg 261(5):e126, 5/2015. e-Pub 5/2015. PMID: 25775077.
3. Vauthey JN, Pawlik TM. Invited Critique - Preoperative biopsy evaluation of chemotherapy-associated liver injuries: looking for a needle in a hay-stack? Arch Surg 147(12):1092, 8/2012.


1. Vauthey JN, Kopetz SE. From multidisciplinary to personalized treatment of colorectal liver metastases: 4 reasons to consider RAS. Cancer 119(23):4083-4085, 12/1/2013. e-Pub 9/19/2013. PMID: 24105015.
2. Tzeng CW, Vauthey JN. Postoperative complications and oncologic outcomes after resection of colorectal liver metastases: the importance of staying on track. Ann Surg Oncol 20(8):2457-2459, 8/2013. e-Pub 4/2013. PMID: 23579874.
3. Vauthey JN, Zimmitti G, Shindo J. From Couinaud to Molecular Biology: The Seven Virtues of HPB Surgery. HPB(14):493-499, 7/2012.
4. Vauthey JN. Colorectal liver metastases: treat effectively upfront and consider the borderline resectable. J Clin Oncol 25(29):4524-4525, 11/2007.

Book Chapters

1. Contreras CM, Brouquet A, Maru DM, Vauthey JN. Hepatic steatosis, steatohepatitis, and chemotherapy-related liver injury. In: Blumgart's Surgery of the Liver, Biliary Tract, and Pancreas. 2, 5th. Ed(s) Belghiti J, Buchler MW, Chapman WC, D'Angelica MI, DeMatteo RP, Hann LE. Elsevier-Saunders: Philadelphia, 999-1005, 2012.

Letters to the Editor

1. Torzilli G, Belghiti J, Kokudo N, Takayama T, Capussotti L, Nuzzo G, Vauthey JN, Choti MA, De Santibanes E, Donadon M, Morenghi E, Makuuchi M`. Reply to Letter to the Editor entitled "A snapshot of the effective indications and results of surgery for hepatocellular carcinoma in tertiary referral centers: Is it adherent to the EASL/AASLD recommendations? An observational study of the HCC East-West Study Group: When the study setting "Ignores" the patients. Ann Surg 257(5):929-937, 03/22/2013, 2/2013. e-Pub 2/2013.
2. Vauthey JN, Kopetz S, Aloia TA, Andreou A. KRAS Mutation in colorectal cancer metastases after adjuvant FOLFOX for the primary. Br J Cancer 107(8):1442-1443, 9/2012. e-Pub 9/2012.

Last updated: 7/14/2016