Jeannelyn S Estrella, M.D.
Department of Anatomical Pathology, Division of Pathology-Lab Medicine Div
About Dr. Jeannelyn S Estrella
I am a GI and Liver Pathology subspecialty trained Anatomic Pathologist with over 10 years experience. My research focus is on GI and pancreatic neuroendocrine tumors, working with researchers and clinicians on in vivo mouse models and translational research to contribute to the current knowledge of the mechanisms of tumorigenesis and improve quality of patient care in this relatively rare disease. I am also the primary Pathologist in the multidisciplinary cancer of unknown primary (CUP) team, reviewing all relevant pathology material and engaging in discussions regarding diagnosis of patients being presented.
Present Title & Affiliation
Primary Appointment
Professor, Department of Pathology, Division of Pathology-Lab Medicine Div, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | University of California, San Diego School of Medicine, La Jolla, California, US, MD |
| 1999 | University of California, San Diego, La Jolla, California, US, BS in General Biology |
Postgraduate Training
| 2010-2011 | Clinical Fellowship, Gastrointestinal and Liver Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2009-2010 | Clinical Fellowship, Surgical Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2006-2009 | Clinical Residency, Anatomic Pathology, New York Presbyterian – Weill Cornell Medical College, New York, New York |
| 2005-2006 | Research Fellowship, Postdoctoral, Neuroscience and Pathology, University of California, La Jolla, California |
Licenses & Certifications
| 2011 | Texas State Medical Board Physician License |
| 2010 | American Board of Pathology - Anatomic Pathology - Lifetime |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2023
Assistant Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2017
Extramural Institutional Committee Activities
Representative, Department of Pathology, PRS Faculty Compensation & Benefit Advisory Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2017
Ad hoc representative, Department of Pathology, PRS Executive Committee, The University of Texas MD Anderson Cancer Center, 2015
Editorial Activities
Editor, Modern Pathology, 2020 - 2024
Honors & Awards
| 2016 | The Shirley Stein Scientific Endowment Research Award, UT MD Anderson Cancer Center |
| 2012 | Best Abstract Award, First Place, Texas Society of Pathology |
| 2011 | Best Abstract Award, Second Place, Chinese American Pathologist Association (CAPA) |
| 2011 | The Jesse H. Jones Fellowship in Cancer Education Award, UT MD Anderson Cancer Center |
| 1999 | Summa cum Laude, University of California, San Diego |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2019. Evolving landscape in NET Pathology. Invited. Expertise Exchange Educational Program in NET. Houston, Texas, US.
- 2017. Update on Pathology, Classification and Staging of Neuroendocrine Tumors. Invited. Medical Education Program on Neuroendocrine Tumors. Houston, Texas, US.
- 2017. Pancreatic Neuroendocrine Neoplasms - Review of Clinically Relevant Information. Invited. Diagnostic Pathology Course. Houston, Texas, US.
National Presentations
- 2022. Challenges in patient selection for immunotherapy - PDL1 immunohistochemistry testing. Invited. International Gastric Cancer Congress 2022. Houston, Texas, US.
- 2015. Pancreatic Neuroendocrine Tumor - An Update. Invited. Department of Pathology and Laboratory Medicine Grand Rounds. Boston, MA, US.
- 2015. Pancreatic Neuroendocrine Tumor - An Update. Invited. Department of Pathology Grand Rounds. Aurora, Colorado, US.
- 2014. Pathologic factors prognostic of survival in patients with GI tract and pancreatic carcinoma treated with neoadjuvant therapy. Invited. Translational Research Program Symposium. Chicago, OH, US.
- 2011. Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Chemoradiation. Invited. Department of Pathology Grand Rounds. Hershey, PA, US.
International Presentations
- 2025. Update on GI and Pancreatic Neuroendocrine Neoplasms - Evidence-based Approach to Clinical Practice. Invited. Diagnostic Pearls in Surgical Pathology: Updates and Interesting Cases. Manila, PH.
- 2025. Interesting Liver Cases. Invited. Diagnostic Pearls in Surgical Pathology: Updates and Interesting Cases. Manila, PH.
- 2018. Well-differentiated Neuroendocrine Neoplasm - Update on Pathology, Classification and Staging. Invited. 7th Biennial MDACC-China Sister Institute Pathology Conference. Changsha, CN.
- 2018. GI Interesting Case Conference. Invited. 7th Biennial MDACC-China Sister Institute Pathology Conference. Changsha, CN.
- 2018. Biomarkers assessment in gastric/GEJ carcinoma - pitfalls and challenges. Invited. 4th Annual Esophagogastric Cancer Research Retreat. Caledon, CA.
- 2017. Pancreatic neuroendocrine neoplasms: review of clinically relevant information. Invited. 13th European Pathology Congress. Milan, IT.
- 2016. Pancreatic Neuroendocrine Tumor - An Update. Invited. Department of Anatomic Pathology Grand Rounds. Toronto, CA.
- 2015. Pancreatic Neuroendocrine Tumor - An Update. Invited. Department of Pathology Grand Rounds. Ottawa, CA.
Grant & Contract Support
| Date: | 2024 - 2025 |
| Title: | Receptor-Targeted Fluorescence-Guided Surgery in Pancreatic Neuroendocrine Tumors |
| Funding Source: | University of Texas Health Science Center - Houston |
| Role: | Collaborator |
| Date: | 2024 - 2028 |
| Title: | Multimodal laparoscope for enhancing surgical localization and margin analysis of pancreatic neuroendocrine |
| Funding Source: | Arizona State University |
| Role: | Collaborator |
| Date: | 2023 - 2026 |
| Title: | Discovery of SSTR2 as a Target for Intraoperative Detection of Hepatocellular Carcinoma |
| Funding Source: | UT Health at the Texas Medical Center |
| Role: | Collaborator |
| Date: | 2021 - 2022 |
| Title: | First in-Human Study of Novel Magnetic Sentinel Lymph Node Mapping in Gastric Cancer |
| Funding Source: | American Gastroenterological Association |
| Role: | Co-I |
| ID: | AGA202021-21-04 |
| Date: | 2018 - 2021 |
| Title: | Harnessing the Immune System in Neuroendocrine Tumors |
| Funding Source: | Conquer Cancer Foundation 2018 Career Development Award (CDA) |
| Role: | Co-PI |
| ID: | RCTS:55781 |
| Date: | 2017 - 2019 |
| Title: | Immune-Suppression and Tumor-Stromal Interaction Mediated by Galectin-3 in Gastric Cancer-Implications of Novel Therapeutic Strategies |
| Funding Source: | Department of Defense (DOD) |
| Role: | Collaborator |
| ID: | CA160433 |
| Date: | 2017 - 2018 |
| Title: | Multidimensional Immune Profiling of Advanced Pancreatic Neuroendocrine Tumors |
| Funding Source: | The Neuroendocrine Tumor Research Foundation |
| Role: | Co-PI |
| Date: | 2016 - 2018 |
| Title: | (PQ4) Mutations in the histone chaperone DAXX drive pancreatic neuroendocrine tumors not ductal adenocarcinomas |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | R21-CA208463-02 |
| Date: | 2016 - 2020 |
| Title: | A Retrospective/Prospective Feasibility Study for Assessment of Actionable Mutations in Patients with Cancer of Unknown Primary (CUP) Using the JAX Clinical Cancer Panel |
| Funding Source: | Jackson Laboratory |
| Role: | Collaborator |
| ID: | LS2016-00052337-RM |
| Date: | 2016 - 2018 |
| Title: | The Mechanistic Underpinnings of Pancreatic Neuroendocrine Tumors |
| Funding Source: | Neuroendocrine Tumor Research Foundation |
| Role: | Collaborator |
| Date: | 2015 - 2016 |
| Title: | ATRX/DAXX immunohistochemistry in stage IV pancreatic neuroendocrine tumors |
| Funding Source: | UT MD Anderson Cancer Center, Department of Pathology |
| Role: | Mentor |
| Date: | 2015 - Present |
| Title: | MicroRNA signature predictive of progression-free survival in stage IV pancreatic neuroendocrine tumors |
| Funding Source: | Department of Pathology Faculty Seed Grant |
| Role: | PI |
| Date: | 2014 - 2016 |
| Title: | MicroRNA signature predictive of progression-free survival in stage IV pancreatic neuroendocrine tumors |
| Funding Source: | Institutional Research Grant - Clinical |
| Role: | PI |
| Date: | 2014 - 2016 |
| Title: | Gastric cancer immunity and immunotherapy |
| Funding Source: | UT MD Anderson Cancer Center SINF |
| Role: | Collaborator |
| ID: | PA14-0170 |
| Date: | 2013 - 2013 |
| Title: | MicroRNA expression profile in pancreatic neuroendocrine tumors |
| Funding Source: | Division of Pathology and Laboratory Medicine |
| Role: | Mentor |
| Date: | 2013 - 2013 |
| Title: | The role of FOXP3+ Tumor infiltrating lymphocytes in EBV-positive Lymphoepithelioma-like Gastric Carcinomas |
| Funding Source: | Division of Pathology and Laboratory Medicine |
| Role: | Mentor |
| Date: | 2013 - 2013 |
| Title: | Prognostic roles of estrogen receptors and estrogen-induced genes in pancreatic neuroendocrine tumors |
| Funding Source: | Division of Pathology and Laboratory Medicine |
| Role: | Mentor |
Selected Publications
Peer-Reviewed Articles
- Daigle, N, Guan, S, Duan, S, Knapp, T, Lee, EJ, Azhdarinia, A, Ghosh, SC, Aghaamiri, S, Hernandez Vargas, S, Ikoma, N, Estrella, JS, Schnermann, MJ, Else, T, Kim, MK, Merchant, JL, Sawyer, TW. Investigating machine learning algorithms to classify label-free images of pancreatic neuroendocrine neoplasms. Biophotonics Discovery 2(4), 2025. e-Pub 2025.
- Ye Q, Estrella J, Kalhor N, Liu A, Han C, Sun H, Middleton LP, Chen H, Albarracin C, Sahin A, Wu Y, Ding Q. TRPS1 expression in neuroendocrine neoplasms of breast and other organs. Histopathology 88(2):524-532, 2025. e-Pub 2025. PMID: 41025885.
- Ayabe, RI, Seo, YD, Melendez, B, Fields, BC, Diggs, LP, Segura Lazcano, R, Singh, BB, Wani, K, Ingram, D, Johnson, S, Chelvanambi, M, Hudgens, CW, Hernandez, S, Ajami, NJ, Wargo, J, Lazar, A, Knafl, M, Woodman, SE, Halperin, DM, Estrella, JS, Maxwell, JE. Cancer Testis Antigen Expression Correlates with Immune Activation and Survival in Small Bowel Neuroendocrine Tumors. JCO Precision Oncology 9, 2025. e-Pub 2025. PMID: 40638874.
- Badgwell, BD, Ikoma, N, Murphy, MB, Li, JJ, Wang, X, Minsky, B, Estrella, JS, Mansfield, PF, Ajani, JA, Das, P. Phase 1 Trial of Total Neoadjuvant Therapy With Short-Course Chemoradiotherapy Followed by Chemotherapy for Patients With Potentially Resectable Gastric Cancer. International Journal of Radiation Oncology Biology Physics 121(2):423-431, 2025. e-Pub 2025. PMID: 39237045.
- Badgwell, BD, Ikoma, N, Blum Murphy, M, Wang, X, Estrella, JS, Liu, X, Kawedia, J, Li, JJ, Mansfield, PF, Ajani, JA. Phase 1 trial of intraperitoneal paclitaxel in patients with gastric adenocarcinoma and carcinomatosis or positive cytology. Cancer 131(1), 2025. e-Pub 2025. PMID: 39287936.
- Serrano, A, Rocha, P, Freitas Lima, C, Stewart, A, Zhang, B, Diao, L, Fujimoto, J, Cardnell, R, Lu, W, Khan, KB, Sable, B, Ellison, AR, Wistuba, II, Concannon, KF, Halperin, DM, Czerniak, BA, Sircar, K, Zhang, M, Cargill, KR, Wang, Q, Aparicio, A, Lazar, A, Hernandez, S, Estrella, JS, Ramalingam, P, El-Naggar, AK, Kalhor, N, Gay, CM, Byers, LA, Solis Soto, LM. Delta-like ligand 3 (DLL3) landscape in pulmonary and extra-pulmonary neuroendocrine neoplasms. npj Precision Oncology 8(1), 2024. e-Pub 2024. PMID: 39558076.
- Ayabe, RI, Seo, YD, Melendez, B, Segura Lazcano, R, Fields, BC, Wani, K, Johnson, S, Witt, RG, Chelvanambi, M, Hudgens, CW, Hernandez, S, Ajami, NJ, Wargo, J, Lazar, A, Halperin, DM, Estrella, JS, Maxwell, JE. Correlation of cancer testis antigen expression with high type-I interferon signal and prognosis in small bowel neuroendocrine tumors. Journal of Clinical Oncology 42(3), 2024. e-Pub 2024.
- Allam, J, Ma, L, Estrella, JS, Willett, A, Beaty, K, Matamoros Jr, A, Lano, EA, Fournier, KF, Treuner, K, Raghav, KS, Huey, RW. Utility of gene expression–based cancer classification in diagnosis of malignant peritoneal mesothelioma (MPeM). Journal of Clinical Oncology 42(3), 2024. e-Pub 2024.
- Pabon, CM, Xiao, L, Badgwell, BD, Mansfield, PF, Ikoma, N, Sewastjanow-Silva, M, Lee, JH, Bhutani, M, Weston, B, Coronel, E, Smith, GL, Holliday, EB, Tian, J, Das, P, Minsky, B, Waters, R, Estrella, JS, Li, JJ, Ajani, JA, Blum Murphy, M. Neoadjuvant dual checkpoint inhibition followed by immune-chemoradiation in patients with resectable gastric adenocarcinoma. Journal of Clinical Oncology 42(16), 2024. e-Pub 2024.
- Hirata, Y, Chiang, YJ, Estrella, JS, Das, P, Minsky, B, Blum Murphy, M, Ajani, JA, Mansfield, PF, Badgwell, BD, Ikoma, N. Independent Stage Classification for Gastroesophageal Junction Adenocarcinoma. Cancers 15(21), 2023. e-Pub 2023. PMID: 37958312.
- Hirata Y, Agnes A, Estrella JS, Blum Murphy M, Das P, Minsky BD, Ajani JA, Badgwell BD, Mansfield P, Ikoma N. Clinical Impact of Positive Surgical Margins in Gastric Adenocarcinoma in the Era of Preoperative Therapy. Ann Surg Oncol 30(8):4936-4945, 2023. e-Pub 2023. PMID: 37106276.
- Huey RW, Shah AT, Reddi HV, Dasari P, Topham JT, Hwang H, Dhillon N, Willett A, Smaglo BG, Estrella JS, Rashid A, Matamoros A, Overman MJ, Choquette L, Omerza G, Kelly K, Wang X, Loree JM, Rueter J, Varadhachary GR, Raghav K. Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study. J Natl Cancer Inst 115(8):994-997, 2023. e-Pub 2023. PMID: 37202363.
- Ayabe RI, Paez-Arango N, Estrella JS, Newhook TE, Tzeng CD, Chun YS, Lee S, Javle M, Vauthey JN, Tran Cao HS. Neoadjuvant chemotherapy for high-risk intrahepatic cholangiocarcinoma - does pathologic response mean better outcomes?. HPB (Oxford) 25(4):472-480, 2023. e-Pub 2023. PMID: 36781357.
- Daigle N, Knapp T, Duan S, Jones DW Jr, Azhdarinia A, Ghosh SC, AghaAmiri S, Ikoma N, Estrella J, Schnermann MJ, Merchant JL, Sawyer TW. Combined multiphoton microscopy and somatostatin receptor type 2 imaging of pancreatic neuroendocrine tumors. bioRxiv, 2023. e-Pub 2023. PMID: 36778307.
- Sun C, Estrella JS, Whitley EM, Chau GP, Lozano G, Wasylishen AR. Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas. Dis Model Mech 15(8), 2022. e-Pub 2022. PMID: 35976056.
- Halperin DM, Liu S, Dasari A, Fogelman D, Bhosale P, Mahvash A, Estrella JS, Rubin L, Morani AC, Knafl M, Overeem TA, Fu SC, Solis LM, Parra Cuentas E, Verma A, Chen HL, Gite S, Subashchandrabose P, Dervin S, Schulze K, Darbonne WC, Yun C, Wistuba II, Futreal PA, Woodman SE, Yao JC. Assessment of Clinical Response Following Atezolizumab and Bevacizumab Treatment in Patients With Neuroendocrine Tumors: A Nonrandomized Clinical Trial. JAMA Oncol 8(6):904-909, 2022. e-Pub 2022. PMID: 35389428.
- Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut 70(12):2238-2248, 2021. e-Pub 2021. PMID: 33487592.
- Hao D, He S, Harada K, Pizzi MP, Lu Y, Guan P, Chen L, Wang R, Zhang S, Sewastjanow-Silva M, Abdelhakeem A, Shanbhag N, Bhutani M, Han G, Lee JH, Zhao S, Weston B, Blum Murphy M, Waters R, Estrella JS, Roy-Chowdhuri S, Gan Q, Lee JS, Peng G, Hanash SM, Calin GA, Song X, Zhang J, Song S, Wang L, Ajani JA. Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma. Gut 70(11):2055-2065, 2021. e-Pub 2021. PMID: 33334899.
- Erstad DJ, Blum M, Estrella JS, Das P, Minsky BD, Ajani JA, Mansfield PF, Ikoma N, Badgwell BD. Benchmarks for nodal yield and ratio for node-positive gastric cancer. Surgery 170(4):1231-1239, 2021. e-Pub 2021. PMID: 34059344.
- Erstad DJ, Blum M, Estrella JS, Das P, Minsky BD, Ajani JA, Mansfield PF, Badgwell BD, Ikoma N. Determinants of Survival for Patients with Neoadjuvant-Treated Node-Negative Gastric Cancer. Ann Surg Oncol 28(11):6638-6648, 2021. e-Pub 2021. PMID: 33754224.
- Abdelhakeem A, Patnana M, Wang X, Rogers JE, Murphy MB, Sagebiel T, Ikoma N, Badgwell BD, Trail A, Estrella JS, Lu Y, Devine C, Ajani JA. Influence of Baseline Positron Emission Tomography in Metastatic Gastroesophageal Cancer on Survival and Response to Therapy. Oncology 99(10):659-664, 2021. e-Pub 2021. PMID: 34352788.
- Ikoma N, Estrella JS, Blum Murphy M, Das P, Minsky BD, Mansfield P, Ajani JA, Badgwell BD. Tumor Regression Grade in Gastric Cancer After Preoperative Therapy. J Gastrointest Surg 25(6):1380-1387, 2021. e-Pub 2021. PMID: 32542556.
- Raghav K, Hwang H, Jácome AA, Bhang E, Willett A, Huey RW, Dhillon NP, Modha J, Smaglo B, Matamoros A, Estrella JS, Jao J, Overman MJ, Wang X, Greco FA, Loree JM, Varadhachary GR. Development and validation of a novel nomogram for individualized prediction of survival in cancer of unknown primary (CUP). Clin Cancer Res 27(12):3414-3421, 2021. e-Pub 2021. PMID: 33858857.
- Lee SH, Simoneau EB, Karpinets T, Futreal PA, Zhang J, Javle M, Zhang J, Vauthey JN, Lee JS, Estrella JS, Chun YS. Genomic Profiling of Multifocal Intrahepatic Cholangiocarcinoma Reveals Intraindividual Concordance of Genetic Alterations. Carcinogenesis 42(3):436-441, 2021. e-Pub 2021. PMID: 33200197.
- Huey RW, Smaglo BG, Estrella JS, Matamoros A, Overman MJ, Varadhachary GR, Raghav KPS. Cancer of Unknown Primary Presenting as Bone-Predominant or Lymph Node-Only Disease: A Clinicopathologic Portrait. Oncologist 26(4):e650-e657, 2021. e-Pub 2021. PMID: 33524217.
- Blumenthaler AN, Newhook TE, Ikoma N, Estrella JS, Blum Murphy M, Das P, Minsky BD, Ajani JA, Mansfield PF, Badgwell BD. Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival. J Surg Oncol 123(4):911-922, 2021. e-Pub 2021. PMID: 33400838.
- Erstad DJ, Blum M, Estrella JS, Das P, Minsky BD, Ajani JA, Mansfield PF, Ikoma N, Badgwell BD. Navigating Nodal Metrics for Node-Positive Gastric Cancer in the United States: An NCDB-Based Study and Validation of AJCC Guidelines. J Natl Compr Canc Netw 19(13):86-97, 2021. e-Pub 2021. PMID: 34678759.
- Badgwell B, Ikoma N, Murphy MB, Wang X, Estrella J, Roy-Chowdhuri S, Das P, Minsky BD, Lano E, Song S, Mansfield P, Ajani J. A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Gastric Cancer and Carcinomatosis or Positive Cytology. Ann Surg Oncol 28(1):258-264, 2021. e-Pub 2021. PMID: 32556731.
- Abdelhakeem AA, Wang X, Waters RE, Patnana M, Estrella JS, Blum Murphy M, Trail AM, Lu Y, Devine CE, Ikoma N, Das P, Badgwell BD, Rogers JE, Ajani JA. Preoperatively Treated Diffuse-Type Gastric Adenocarcinoma: Glucose vs. Other Energy Sources Substantially Influence Prognosis and Therapy Response. Cancers (Basel) 13(3):1-10, 2021. e-Pub 2021. PMID: 33498613.
- Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, Pizzi MP, Scott A, Harada K, Ma L, Yao X, Jin J, Zhao W, Dong X, Badgwell BD, Shanbhag N, Tatlonghari G, Estrella JS, Roy-Chowdhuri S, Kobayashi M, Vykoukal JV, Hanash SM, Calin GA, Peng G, Lee JS, Johnson RL, Wang Z, Wang L, Song S. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut 70(1):55-66, 2021. e-Pub 2021. PMID: 32345613.
- Wang R, Dang M, Harada K, Han G, Wang F, Pool Pizzi M, Zhao M, Tatlonghari G, Zhang S, Hao D, Lu Y, Zhao S, Badgwell BD, Blum Murphy M, Shanbhag N, Estrella JS, Roy-Chowdhuri S, Abdelhakeem AAF, Wang Y, Peng G, Hanash S, Calin GA, Song X, Chu Y, Zhang J, Li M, Chen K, Lazar AJ, Futreal A, Song S, Ajani JA, Wang L. Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma. Nat Med 27(1):141-151, 2021. e-Pub 2021. PMID: 33398161.
- Yang JY, Jie Z, Mathews A, Zhou X, Li Y, Gu M, Xie X, Ko CJ, Cheng X, Qi Y, Estrella JS, Wang J, Sun SC. Intestinal Epithelial TBK1 Prevents Differentiation of T-helper 17 Cells and Tumorigenesis in Mice. Gastroenterology 159(5):1793-1806, 2020. e-Pub 2020. PMID: 32745468.
- Kim BJ, Chiang YJ, Das P, Minsky BD, Blum MA, Ajani JA, Estrella JS, Hofstetter WL, Tzeng CD, Badgwell BD, Mansfield PF, Ikoma N. Treatment Patterns for Gastroesophageal Junction Adenocarcinoma in the United States. J Clin Med 9(11), 2020. e-Pub 2020. PMID: 33138060.
- Harada K, Patnana M, Wang X, Iwatsuki M, Murphy MAB, Zhao M, Das P, Minsky BD, Weston B, Lee JH, Bhutani MS, Estrella JS, Shanbhag N, Ikoma N, Badgwell BD, Ajani JA. Low metabolic activity in primary gastric adenocarcinoma is associated with resistance to chemoradiation and the presence of signet ring cells. Surg Today 50(10):1223-1231, 2020. e-Pub 2020. PMID: 32409870.
- Stark AP, Estrella JS, Chiang YJ, Das P, Minsky BD, Blum Murphy MA, Ajani JA, Mansfield P, Badgwell BD, Ikoma N. Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer. J Surg Oncol 122(3):422-432, 2020. e-Pub 2020. PMID: 32462681.
- Stark AP, Blum MM, Chiang YJ, Das P, Minsky BD, Estrella JS, Ajani JA, Badgwell BD, Mansfield P, Ikoma N. Preoperative Therapy Regimen Influences the Incidence and Implication of Nodal Downstaging in Patients with Gastric Cancer. J Gastric Cancer 20(3):313-327, 2020. e-Pub 2020. PMID: 33024587.
- Wasylishen AR, Sun C, Moyer SM, Qi Y, Chau GP, Aryal NK, McAllister F, Kim MP, Barton MC, Estrella JS, Su X, Lozano G. Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Sci Adv 6(32):eaba8415, 2020. e-Pub 2020. PMID: 32821827.
- Blum Murphy M, Ikoma N, Wang X, Estrella JS, Roy-Chowdhuri S, Das P, Minsky BD, Song S, Mansfield P, Ajani J, Badgwell B. Phase I Trial of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) with Cisplatin, Mitomycin, and Paclitaxel in Patients with Gastric Adenocarcinoma and Associated Carcinomatosis or Positive Cytology. Ann Surg Oncol 27(8):2806-2811, 2020. e-Pub 2020. PMID: 31974712.
- Zafar SN, Blum M, Chiang YJ, Ajani JA, Estrella JS, Das P, Minsky BD, Hofstetter WL, Mansfield P, Badgwell BD, Ikoma N. Preoperative Chemoradiation versus Chemotherapy in Gastroesophageal Junction Adenocarcinoma. Ann Thorac Surg 110(2):398-405, 2020. e-Pub 2020. PMID: 32289300.
- Ikoma N, Agnes A, Chen HC, Wang X, Blum MM, Das P, Minsky B, Estrella JS, Mansfield P, Ajani JA, Badgwell BD. Linitis Plastica: a Distinct Type of Gastric Cancer. J Gastrointest Surg 24(5):1018-1025, 2020. e-Pub 2020. PMID: 31754987.
- Song S, Wang Z, Li Y, Ma L, Jin J, Scott AW, Xu Y, Estrella JS, Song Y, Liu B, Johnson RL, Ajani JA. PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression. Mol Cancer Res 18(3):390-402, 2020. e-Pub 2020. PMID: 31796534.
- Wasylishen AR, Sun C, Chau GP, Qi Y, Su X, Kim MP, Estrella JS, Lozano G. Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress. Proc Natl Acad Sci U S A 117(12):6622-6629, 2020. e-Pub 2020. PMID: 32156729.
- Wang R, Song S, Harada K, Ghazanfari Amlashi F, Badgwell B, Pizzi MP, Xu Y, Zhao W, Dong X, Jin J, Wang Y, Scott A, Ma L, Huo L, Vicente D, Blum Murphy M, Shanbhag N, Tatlonghari G, Thomas I, Rogers J, Kobayashi M, Vykoukal J, Estrella JS, Roy-Chowdhuri S, Han G, Zhang S, Mao X, Song X, Zhang J, Gu J, Johnson RL, Calin GA, Peng G, Lee JS, Hanash SM, Futreal A, Wang Z, Wang L, Ajani JA. Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response. Gut 69(1):18-31, 2020. e-Pub 2020. PMID: 31171626.
- Abdelhakeem A, Wang X, Rogers JE, Trail A, Zhao M, Blum-Murphy M, Estrella JS, Ajani JA. Outcomes of Advanced Gastroesophageal Cancer Patients with Equivocal HER2 Expression with or without ERBB2 Gene Amplification. Oncology 98(12):884-888, 2020. e-Pub 2020. PMID: 32998149.
- Sonoda K, Samdani RT, Ikoma N, Kaya DM, Blum-Murphy M, Ajani JA, Badgwell BD, Katz MH, Rashid A, Estrella JS. Gastric cancer in the remnant stomach after pancreaticoduodenectomy: A case series. J Surg Oncol 120(7):1137-1141, 2019. e-Pub 2019. PMID: 31498442.
- Wang M, Estrella JS, Katz MH, Kim M, Rashid A, Lee JE, Maitra A, Wistuba II, Wolff RA, Varadhachary GR, Wang H. Expression of Epithelial-Mesenchymal Transition Markers in Treated Pancreatic Ductal Adenocarcinoma. Pancreas 48(10):1367-1372, 2019. e-Pub 2019. PMID: 31688603.
- Huey RW, Makawita S, Xiao L, Matamoros A, Estrella JS, Overman MJ, Varadhachary GR, Raghav K. Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait. BMC Cancer 19(1):965, 2019. e-Pub 2019. PMID: 31623602.
- Stark AP, Ikoma N, Chiang YJ, Estrella JS, Das P, Minsky BD, Blum MM, Ajani JA, Mansfield P, Badgwell BD. Characteristics and Survival of Gastric Cancer Patients with Pathologic Complete Response to Preoperative Therapy. Ann Surg Oncol 26(11):3602-3610, 2019. e-Pub 2019. PMID: 31350645.
- Newhook TE, Agnes A, Blum M, Estrella JS, Das P, Ho L, Ajani JA, Minsky BD, Mansfield P, Badgwell BD. Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases from Gastric Cancer and May Lead to Gastrectomy. Ann Surg Oncol 26(5):1394-1400, 2019. e-Pub 2019. PMID: 30680477.
- Samdani RT, Wasylishen AR, Halperin DM, Dasari A, Yao JC, Rashid A, Estrella JS. Loss of Menin Expression by Immunohistochemistry in Pancreatic Neuroendocrine Tumors: Comparison Between Primary and Metastatic Tumors. Pancreas 48(4):510-513, 2019. e-Pub 2019. PMID: 30946241.
- Halperin DM, Lee JJ, Ng CS, Strosberg JR, Estrella JS, Dagohoy CG, Dasari A, Yao JC. A Phase II Trial of Ziv-Aflibercept in Patients With Advanced Pancreatic Neuroendocrine Tumors. Pancreas 48(3):381-386, 2019. e-Pub 2019. PMID: 30768575.
- Ikoma N, Das P, Hofstetter W, Ajani JA, Estrella JS, Chen HC, Wang X, Callender RA, Zhu C, Roland CL, Fournier KF, Cormier JN, Mansfield P, Badgwell BD. Preoperative chemoradiation therapy induces primary-tumor complete response more frequently than chemotherapy alone in gastric cancer: analyses of the National Cancer Database 2006-2014 using propensity score matching. Gastric Cancer 21(6):1004-1013, 2018. e-Pub 2018. PMID: 29730720.
- Ikoma N, Estrella JS, Hofstetter WL, Ajani JA, Fournier KF, Mansfield PF, Skibber JM, Badgwell BD. Surgeon Assessment of Gastric Cancer Lymph Node Specimens with a Video of Technique. J Gastrointest Surg 22(11):2013-2019, 2018. e-Pub 2018. PMID: 30054780.
- Wasylishen AR, Estrella JS, Pant V, Chau GP, Lozano G. Daxx Functions are p53-independent In Vivo. Mol Cancer Res 16(10):1523-1529, 2018. e-Pub 2018. PMID: 29903771.
- Ikoma N, Estrella JS, Blum M, Das P, Chen HC, Wang X, Fournier K, Mansfield P, Ajani J, Badgwell BD. Central Lymph Node Metastasis in Gastric Cancer Is Predictive of Survival After Preoperative Therapy. J Gastrointest Surg 22(8):1325-1333, 2018. e-Pub 2018. PMID: 29679346.
- Thiels CA, Ikoma N, Fournier K, Das P, Blum M, Estrella JS, Minsky BD, Ajani J, Mansfield P, Badgwell BD. Repeat staging laparoscopy for gastric cancer after preoperative therapy. J Surg Oncol 118(1):61-67, 2018. e-Pub 2018. PMID: 29878364.
- Ikoma N, Estrella JS, Hofstetter W, Das P, Minsky BD, Ajani JA, Fournier KF, Mansfield P, Badgwell BD. Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved. Ann Surg Oncol 25(7):2012-2017, 2018. e-Pub 2018. PMID: 29748883.
- Mizrak Kaya D, Nogueras-Gonzáles GM, Harada K, Amlashi FG, Thomas I, Rogers JE, Bhutani MS, Lee JH, Weston B, Minsky BD, Estrella JS, Blum Murphy MA, Matamoros A, Devine CE, Das P, Badgwell BD, Ajani JA. Potentially curable gastric adenocarcinoma treated without surgery. Eur J Cancer 98:23-29, 2018. e-Pub 2018. PMID: 29859338.
- Ikoma N, Hofstetter WL, Estrella JS, Das P, Minsky BD, Fournier KF, Mansfield PF, Ajani JA, Badgwell BD. The ypT category does not impact overall survival in node negative gastric cancer. J Surg Oncol 117(8):1721-1728, 2018. e-Pub 2018. PMID: 29949666.
- Mizrak Kaya D, Nogueras-González GM, Harada K, Amlashi FG, Roy-Chowdhuri S, Estrella JS, Das P, Lee JH, Weston B, Bhutani MS, Matamoros A, Thomas I, Lin Q, Badgwell BD, Ajani JA. Risk of peritoneal metastases in patients who had negative peritoneal staging and received therapy for localized gastric adenocarcinoma. J Surg Oncol 117(4):678-684, 2018. e-Pub 2018. PMID: 29205363.
- Ikoma N, Blum M, Estrella JS, Das P, Hofstetter WL, Fournier KF, Mansfield P, Ajani JA, Badgwell BD. Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy. Gastric Cancer 21(1):74-83, 2018. e-Pub 2018. PMID: 28643144.
- Badgwell B, Blum M, Das P, Estrella JS, Wang X, Fournier K, Royal R, Mansfield P, Ajani J. Lessons learned from a phase II clinical trial of laparoscopic HIPEC for gastric cancer. Surg Endosc 32(1):512, 2018. e-Pub 2018. PMID: 28643069.
- Harada K, Dong X, Estrella JS, Correa AM, Xu Y, Hofstetter WL, Sudo K, Onodera H, Suzuki K, Suzuki A, Johnson RL, Wang Z, Song S, Ajani JA. Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma. Gastric Cancer 21(1):31-40, 2018. e-Pub 2018. PMID: 28801853.
- Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S. Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors. Br J Cancer 118(1):52-61, 2018. e-Pub 2018. PMID: 29136404.
- Ikoma N, Das P, Blum M, Estrella JS, Devine CE, Wang X, Fournier K, Mansfield P, Minsky BD, Ajani J, Badgwell BD. Preoperative Chemoradiation Therapy Does Not Increase Risk of Anastomotic Leak in Patients With Gastric Cancer. Int J Radiat Oncol Biol Phys 99(3):660-666, 2017. e-Pub 2017. PMID: 29280460.
- Ikoma N, Blum M, Estrella JS, Wang X, Fournier KF, Mansfield PF, Ajani JA, Badgwell BD. Left Gastric Artery Lymph Nodes Should Be Included in D1 Lymph Node Dissection in Gastric Cancer. J Gastrointest Surg 21(10):1563-1570, 2017. e-Pub 2017. PMID: 28819789.
- Badgwell B, Blum M, Das P, Estrella JS, Wang X, Ho L, Fournier K, Royal R, Mansfield P, Ajani J. Phase II Trial of Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion for Peritoneal Carcinomatosis or Positive Peritoneal Cytology in Patients with Gastric Adenocarcinoma. Ann Surg Oncol 24(11):3338-3344, 2017. e-Pub 2017. PMID: 28799004.
- Elimova E, Slack RS, Chen HC, Planjery V, Shiozaki H, Shimodaira Y, Charalampakis N, Lin Q, Harada K, Wadhwa R, Estrella JS, Kaya DM, Sagebiel T, Lee JH, Weston B, Bhutani M, Murphy MB, Matamoros A, Minsky B, Das P, Mansfield PF, Badgwell BD, Ajani JA. Patterns of relapse in patients with localized gastric adenocarcinoma who had surgery with or without adjunctive therapy: costs and effectiveness of surveillance. Oncotarget 8(46):81430-81440, 2017. e-Pub 2017. PMID: 29113402.
- Ikoma N, Chen HC, Wang X, Blum M, Estrella JS, Fournier K, Mansfield P, Ajani J, Badgwell BD. Patterns of Initial Recurrence in Gastric Adenocarcinoma in the Era of Preoperative Therapy. Ann Surg Oncol 24(9):2679-2687, 2017. e-Pub 2017. PMID: 28332034.
- Charalampakis N, Xiao L, Lin Q, Elimova E, Shimodaira Y, Harada K, Rogers JE, Mares J, Amlashi FG, Minsky BD, Das P, Hofstetter WL, Matamoros A, Sagebiel TL, Blum-Murphy MA, Lee JH, Weston B, Bhutani MS, Mansfield PF, Estrella JS, Badgwell BD, Ajani JA. Co-morbidities Rather than Age Impact Outcomes in Patients Receiving Preoperative Therapy for Gastroesophageal Adenocarcinoma. Ann Surg Oncol 24(8):2291-2301, 2017. e-Pub 2017. PMID: 27770339.
- Mizrak Kaya D, Dong X, Nogueras-González GM, Xu Y, Estrella JS, Harada K, Lopez A, Amlashi FG, Hofstetter WL, Maru DM, Nguyen QN, Lee JH, Weston B, Bhutani MS, Erasmus JJ, Thomas I, Rogers JE, Song S, Ajani JA. Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients. Med Oncol 34(8):135, 2017. e-Pub 2017. PMID: 28685276.
- Ikoma N, Blum M, Chiang YJ, Estrella JS, Roy-Chowdhuri S, Fournier K, Mansfield P, Ajani J, Badgwell BD. Race Is a Risk for Lymph Node Metastasis in Patients With Gastric Cancer. Ann Surg Oncol 24(4):960-965, 2017. e-Pub 2017. PMID: 27778127.
- Roland CL, Starker LF, Kang Y, Chatterjee D, Estrella JS, Rashid A, Katz MH, Aloia TA, Lee JE, Dasari A, Yao JC, Fleming JB. Loss of DPC4/SMAD4 expression in primary gastrointestinal neuroendocrine tumors is associated with cancer-related death after resection. Surgery 161(3):753-759, 2017. e-Pub 2017. PMID: 27816207.
- Mizrak Kaya D, Wang X, Harada K, Blum Murphy MA, Das P, Minsky BD, Estrella JS, Lin Q, Amlashi FG, Lee JH, Weston B, Bhutani MS, Matamoros A, Sagebiel T, Wu CC, Rogers JE, Thomas I, Maru DM, Skinner HD, Badgwell BD, Hofstetter WL, Ajani JA. 101 Long-Term Survivors Who Had Metastatic Gastroesophageal Cancer and Received Local Consolidative Therapy. Oncology 93(4):243-248, 2017. e-Pub 2017. PMID: 28683449.
- Saab J, Estrella JS, Chen YT, Yantiss RK. Immunohistochemical and molecular features of gastric hyperplastic polyps. Adv Cytol Pathol 2(1):00012, 2017. e-Pub 2017.
- Ikoma N, Blum M, Chiang YJ, Estrella JS, Roy-Chowdhuri S, Fournier K, Mansfield P, Ajani JA, Badgwell BD. Yield of Staging Laparoscopy and Lavage Cytology for Radiologically Occult Peritoneal Carcinomatosis of Gastric Cancer. Ann Surg Oncol 23(13):4332-4337, 2016. e-Pub 2016. PMID: 27384751.
- Ikoma N, Blum M, Chiang YJ, Estrella JS, Roy-Chowdhuri S, Fournier K, Mansfield P, Ajani JA, Badgwell BD. Survival rates in T1 and T2 gastric cancer: A Western report. J Surg Oncol 114(5):602-606, 2016. e-Pub 2016. PMID: 27439746.
- Al-Shamsi HO, Fahmawi Y, Dahbour I, Tabash A, Rogers JE, Mares JE, Blum MA, Estrella JS, Matamoros A, Sagebiel T, Devine CE, Badgwell BD, Lin QD, Das P, Ajani JA. Continuation of trastuzumab beyond disease progression in HER2-positive metastatic gastric cancer: the MD Anderson experience. J Gastrointest Oncol 7(4):499-505, 2016. e-Pub 2016. PMID: 27563438.
- Badgwell B, Blum M, Elimova E, Estrella JS, Chiang YJ, Das P, Mansfield P, Ajani J. Frequency of Resection After Preoperative Chemotherapy or Chemoradiotherapy for Gastric Adenocarcinoma. Ann Surg Oncol 23(6):1948-55, 2016. e-Pub 2016. PMID: 26868957.
- Conte B, George B, Overman M, Estrella JS, Jiang ZQ, Mehrvarz Sarshekeh A, Ferrarotto R, Hoff PM, Rashid A, Yao JC, Kopetz S, Dasari A. High-Grade Neuroendocrine Colorectal Carcinomas: A Retrospective Study of 100 Patients. Clin Colorectal Cancer 15(2):e1-7, 2016. e-Pub 2016. PMID: 26810202.
- Charalampakis N, Nogueras González GM, Elimova E, Wadhwa R, Shiozaki H, Shimodaira Y, Blum MA, Rogers JE, Harada K, Matamoros A, Sagebiel T, Das P, Minsky BD, Lee JH, Weston B, Bhutani MS, Estrella JS, Badgwell BD, Ajani JA. The Proportion of Signet Ring Cell Component in Patients with Localized Gastric Adenocarcinoma Correlates with the Degree of Response to Pre-Operative Chemoradiation. Oncology 90(5):239-47, 2016. e-Pub 2016. PMID: 27046280.
- Fischer LK, Katz MH, Lee SM, Liu L, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Roland CL, Fleming JB, Estrella JS, Rashid A, Wang H. The Number and Ratio of Positive Lymph Nodes Affect Pancreatic Cancer Patient Survival after Neoadjuvant Therapy and Pancreaticoduodenectomy. Histopathology 68(2):210-20, 2016. e-Pub 2016. PMID: 25945396.
- Shiozaki H, Elimova E, Slack RS, Chen HC, Staerkel GA, Sneige N, Shimodaira Y, Sagebiel T, Lee JH, Bhutani MS, Das P, Mansfield PF, Estrella JS, Badgwell BD, Ajani JA. Prognosis of Gastric Adenocarcinoma Patients with Various Burdens of Peritoneal Metastases. J Surg Oncol 113(1):29-35, 2016. e-Pub 2016. PMID: 26603684.
- Shiozaki H, Slack RS, Chen HC, Elimova E, Planjery V, Charalampakis N, Wadhwa R, Shimodaira Y, Skinner H, Lee JH, Weston B, Bhutani MS, Blum-Murphy M, Rogers JE, Maru DM, Matamoros A, Sagebiel T, Estrella JS, Das P, Hofstetter WL, Mares JE, Mizrak Kaya D, Harada K, Lin Q, Minsky BD, Badgwell BD, Ajani JA. Metastatic Gastroesophageal Adenocarcinoma Patients Treated with Systemic Therapy Followed by Consolidative Local Therapy: A Nomogram Associated with Long-Term Survivors. Oncology 91(1):55-60, 2016. e-Pub 2016. PMID: 27120436.
- Estrella JS, Tetzlaff MT, Bassett RL, Patel KP, Williams MD, Curry JL, Rashid A, Hamilton SR, Broaddus RR. Assessment of BRAF V600E Status in Colorectal Carcinoma: Tissue-Specific Discordances between Immunohistochemistry and Sequencing. Mol Cancer Ther 14(12):2887-95, 2015. e-Pub 2015. PMID: 26438153.
- Charalampakis N, Xiao L, Elimova E, Wadhwa R, Shiozaki H, Shimodaira Y, Blum MA, Planjery V, Rogers JE, Matamoros A, Sagebiel T, Das P, Lee JH, Bhutani MS, Weston B, Estrella JS, Badgwell BD, Ajani JA. Initial Standardized Uptake Value of Positron Emission Tomography Influences the Prognosis of Patients with Localized Gastric Adenocarcinoma Treated Preoperatively. Oncology 89(6):305-10, 2015. e-Pub 2015. PMID: 26393501.
- Liu L, Katz MH, Lee SM, Fischer LK, Prakash L, Parker N, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Maitra A, Fleming JB, Estrella JS, Rashid A, Wang H. Superior Mesenteric Artery Margin of Posttherapy Pancreaticoduodenectomy and Prognosis in Patients with Pancreatic Ductal Adenocarcinoma. Am J Surg Pathol 39(10):1395-403, 2015. e-Pub 2015. PMID: 26200098.
- Tetzlaff MT, Pattanaprichakul P, Wargo J, Fox PS, Patel KP, Estrella JS, Broaddus RR, Williams MD, Davies MA, Routbort MJ, Lazar AJ, Woodman SE, Hwu WJ, Gershenwald JE, Prieto VG, Torres-Cabala CA, Curry JL. Utility of BRAF V600E immunohistochemical expression pattern as a surrogate of BRAF mutation status in 154 patients with advanced melanoma. Hum Pathol 46(8):1101-10, 2015. e-Pub 2015. PMID: 26058727.
- Estrella JS, Wang H, Bhosale PR, Evans HL, Abraham SC. Malignant Solitary Fibrous Tumor of the Pancreas. Pancreas 44(6):988-94, 2015. e-Pub 2015. PMID: 26166470.
- Badgwell B, Blum M, Estrella JS, Chiang YJ, Das P, Matamoros A, Fournier K, Mansfield P, Ajani J. Predictors of Survival in Patients with Resectable Gastric Cancer Treated with Preoperative Chemoradiation Therapy and Gastrectomy. J Am Coll Surg 221(1):83-90, 2015. e-Pub 2015. PMID: 26002780.
- Elimova E, Wadhwa R, Shiozaki H, Sudo K, Estrella JS, Badgwell BD, Das P, Matamoros A, Song S, Ajani JA. Molecular biomarkers in gastric cancer. J Natl Compr Canc Netw 13(4):e19-29, 2015. e-Pub 2015. PMID: 26052595.
- Elimova E, Shiozaki H, Slack RS, Chen HC, Wadhwa R, Sudo K, Charalampakis N, Hiremath A, Estrella JS, Matamoros A, Sagebiel T, Das P, Rogers JE, Garris JL, Blum MA, Badgwell B, Ajani JA. Early versus Delayed Therapy of Advanced Gastric Cancer Patients - Does It Make a Difference?. Oncology 89(4):215-20, 2015. e-Pub 2015. PMID: 26159599.
- Estrella JS, Ma LT, Milton DR, Yao JC, Wang H, Rashid A, Broaddus RR. Expression of estrogen-induced genes and estrogen receptor beta in pancreatic neuroendocrine tumors: implications for targeted therapy. Pancreas 43(7):996-1002, 2014. e-Pub 2014. PMID: 25058880.
- Estrella JS, Taggart MW, Rashid A, Abraham SC. Low-grade neuroendocrine tumors arising in intestinal adenomas: evidence for alterations in the adenomatous polyposis coli/β-catenin pathway. Hum Pathol 45(10):2051-8, 2014. e-Pub 2014. PMID: 25149552.
- Li Y, Liu Z, Liu H, Wang LE, Onodera H, Suzuki A, Suzuki K, Wadhwa R, Elimova E, Sudo K, Shiozaki H, Estrella JS, Lee JS, Song S, Tan D, Ajani JA, Wei Q. Potentially Functional Variants in the Core Nucleotide Excision Repair Genes Predict Survival in Japanese Gastric Cancer Patients. Carcinogenesis 35(9):2031-8, 2014. e-Pub 2014. PMID: 24990617.
- Estrella JS, Broaddus RR, Mathews A, Milton DR, Yao JC, Wang H, Rashid A. Progesterone receptor and PTEN expression predict survival in patients with low- and intermediate-grade pancreatic neuroendocrine tumors. Arch Pathol Lab Med 138(8):1027-36, 2014. e-Pub 2014. PMID: 25076292.
- Wadhwa R, Elimova E, Shiozaki H, Sudo K, Blum MA, Estrella JS, Chen Q, Song S, Ajani JA. Anti-angiogenic agent ramucirumab: meaningful or marginal?. Expert Rev Anticancer Ther 14(4):367-79, 2014. e-Pub 2014. PMID: 24605771.
- Estrella JS, Li L, Rashid A, Wang H, Katz MH, Fleming JB, Abbruzzese JL, Wang H. Solid Pseudopapillary Neoplasm of the Pancreas: Clinicopathologic and Survival Analyses of 64 Cases from A Single Institution. Am J Surg Pathol 38(2):147-57, 2014. e-Pub 2014. PMID: 24418850.
- Elimova E, Wadhwa R, Estrella JS, Sudo K, Shiozaki H, Blum MA, Chen Q, Song S, Das P, Ajani JA. Anal canal cancer: Biology and therapy. Expert Opinion on Orphan Drugs 2(2):137-146, 2014. e-Pub 2014.
- Chatterjee D, Katz MH, Rashid A, Estrella JS, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB, Wang H. Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology 63(6):841-51, 2013. e-Pub 2013. PMID: 24111684.
- Estrella JS, Othman ML, Taggart MW, Hamilton SR, Curley SA, Rashid A, Abraham SC. Intrabiliary Growth of Liver Metastases: Clinicopathologic Features, Prevalence, and Outcome. Am J Surg Pathol 37(10):1571-9, 2013. e-Pub 2013. PMID: 23797727.
- Estrella JS, Wolf JK, Deavers MT. Ovarian Serous Carcinoma Associated With a Distinct "Corded and Hyalinized" Pattern. Arch Pathol Lab Med 137(2):275-279, 2013. e-Pub 2013. PMID: 23368871.
- Wang J, Estrella JS, Peng L, Rashid A, Varadhachary GR, Wang H, Lee JE, Pisters PW, Vauthey JN, Katz MH, Gomez HF, Evans DB, Abbruzzese JL, Fleming JB, Wang H. Histologic Tumor Involvement of Superior Mesenteric Vein/Portal Vein Predicts Poor Prognosis in Patients with Stage II Pancreatic Adenocarcinoma Treated with Neoadjuvant Chemoradiation. Cancer 118(15):3801-11, 2012. e-Pub 2012. PMID: 22180096.
- Estrella JS, Rashid A, Fleming JB, Katz MH, Lee JE, Wolf RA, Varadhachary GR, Pisters PW, Abdalla EK, Vauthey JN, Wang H, Gomez HF, Evans DB, Abbruzzese JL, Wang H. Post-therapy pathologic stage and survival in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant chemoradiation. Cancer 118(1):268-77, 2012. e-Pub 2012. PMID: 21735446.
- Suzuki A, Xiao L, Taketa T, Blum MA, Matamoros A, Chien PL, Mansfield PF, Fournier KF, Weston B, Lee JH, Bhutani MS, Estrella JS, Delclos ME, Krishnan S, Das P, Ajani JA. Localized Gastric Cancer Treated with Chemoradation Without Surgery: UT M. D. Anderson Cancer Center Experience. Oncology 82(6):347-351, 2012. e-Pub 2012. PMID: 22677933.
- Estrella JS, Hofstetter WL, Correa AM, Swisher SG, Ajani JA, Lee JH, Bhutani MS, Abraham SC, Rashid A, Maru DM. Duplicated Muscularis Mucosae Invasion has Similar Risk of Lymph Node Metastasis and Recurrence-Free Survival as Intramucosal Esophageal Adenocarcinoma. Am J Surg Pathol 35(7):1045-53, 2011. e-Pub 2011. PMID: 21602659.
- Estrella JS, Wu TT, Rashid A, Abraham SC. Mucosal Colonization of Metastatic Carcinoma to the Gastrointestinal Tract: A Potential Mimic of Primary Neoplasia. Am J Surg Pathol 35(4):563-72, 2011. e-Pub 2011. PMID: 21412071.
- Ubhi K, Peng K, Lessig S, Estrella JS, Adame A, Galasko D, Salmon DP, Hansen LA, Kawas CH, Masliah E. Neuropathology of Dementia with Lewy Bodies in Advanced Age: A Comparison with Alzheimer Disease. Neurosci Lett 485(3):222-7, 2010. e-Pub 2010. PMID: 20849919.
- Estrella JS, Nelson RN, Sturges BK, Vernau KM, Williams DC, LeCouteur RA, Shelton GD, Mizisin AP. Endoneurial Microvascular Pathology in Feline Diabetic Neuropathy. Microvasc Res 75(3):403-10, 2008. e-Pub 2008. PMID: 18207200.
- He B, Xu W, Santini PA, Polydorides AD, Chiu A, Estrella JS, Shan M, Chadburn A, Villanacci V, Plebani A, Knowles DM, Rescigno M, Cerutti A. Intestinal Bacteria Trigger T cell-independent Immunoglobulin A(2) Class Switching by Inducing Epithelial-cell Secretion of the Cytokine APRIL. Immunity 26(6):812-26, 2007. e-Pub 2007. PMID: 17570691.
- Nguyen LQ, Estrella JS, Jett EA, Grunvald EL, Nicholson L, Levin DL. Acute Schistosomiasis in Nonimmune Travelers: Chest CT Findings in 10 Patients. AJR Am J Roentgenol 186(5):1300-3, 2006. e-Pub 2006. PMID: 16632722.
Invited Articles
- Badgwell B, Blum M, Estrella JS, Ajani J. Personalised therapy for localised gastric and gastro-oesophageal adenocarcinoma. Lancet Oncol 17(12):1628-1629, 2016. e-Pub 2016. PMID: 27776842.
Review Articles
- Badgwell, BD, Das, P, Ikoma, N, Blum Murphy, M, Li, JJ, Estrella, JS, Minsky, B, Mansfield, PF, Ajani, JA. Phase I trial of short-course chemoradiotherapy followed by chemotherapy as total neoadjuvant therapy for patients with potentially resectable gastric cancer. Journal of Clinical Oncology 42:362, 2024. e-Pub 2024.
- Badgwell, BD, Blum Murphy, M, Ikoma, N, Estrella, JS, Li, JJ, Kawedia, J, Mansfield, PF, Ajani, JA. Phase I trial of intraperitoneal paclitaxel in patients with gastric adenocarcinoma and peritoneal carcinomatosis or positive peritoneal cytology. Journal of Clinical Oncology 42:360, 2024. e-Pub 2024.
- Agnes A, Estrella JS, Badgwell B. The significance of a nineteenth century definition in the era of genomics: linitis plastica. World J Surg Oncol 15(1):123, 2017. e-Pub 2017. PMID: 28679451.
- Shiozaki H, Shimodaira Y, Elimova E, Wadhwa R, Sudo K, Harada K, Estrella JS, Das P, Badgwell B, Ajani JA. Evolution of gastric surgery techniques and outcomes. Chin J Cancer 35(1):69, 2016. e-Pub 2016. PMID: 27460019.
- Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA. Medical management of gastric cancer: A 2014 update. World J Gastroenterol 20(38):13637-13647, 2014. e-Pub 2014. PMID: 25320502.
Other Articles
- Aghaamiri, S, Estrella, JS, Vargas, SH, Hurd, MW, Ghosh, SC, Azhdarinia, A, Ikoma, N Translational Potential of a Contrast Agent for FGS Applications in pNETs. Molecular Imaging and Biology 26(2):191-194, 2024. PMID: 38267640.
Abstracts
- Shiozaki H, Elimova E, Slack R, H-C C, Staerkel GA, Sneige N, Planjery V, Charalampakis N, Wadhwa R, Sudo K, Matamoros A, Lee JH, Weston B, Bhutani MS, Blum MA, Estrella JS, Das P, Mansfield PF, Badgwell BD, and Ajani JA. Prognosis of gastric cancer (GC) patients with positive peritoneal cytology. 2015 ASCO MEETING, 2015. e-Pub 2015.
- Gonzalez-Berjon MJ, Tetzlaff MT, Yao JC, Loose DS, Broaddus R, Estrella JS. MicroRNA Associated With Outcome in Pancreatic Neuroendocrine Tumors. 2015 USCAP Annual Meeting, Boston, MA, 2015. e-Pub 2015.
- Fischer L, Katz MH, Lee SM, Liu L, Sundar M, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Maitra A, Fleming JB, Estrella JS, Rashid A, Wang H. Prognostic Significance of the Number and Ratio of Positive Lymph Nodes for Patients With Pancreatic Ductal Adenocarcinoma Who Completed Neoadjuvant Therapy and Pancreaticoduodenectomy. 2015 USCAP Annual Meeting, Boston, MA, 2015. e-Pub 2015.
- Liu L, Katz MH, Lee SM, Fischer LK, Sundar M, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Maitra A, Fleming JB, Estrella JS, Rashid A, Wang H. Margin Status of Posttherapy Pancreaticoduodenectomy and Prognosis in Patients With Pancreatic Ductal Adenocarcinoma. 2015 USCAP Annual Meeting, Boston, MA, 2015. e-Pub 2015.
- Agarwal A, Tan D, Abraham S, Taggart MW, Wang H, Estrella JS, Zhang M, Rashid A, Maru D. Retrospective Study of Clinicopathologic Features and Patient Outcome of Primary Adenosquamous Carcinoma of the Esophagus. 2015 USCAP Annual Meeting, Boston, MA, 2015. e-Pub 2015.
- Agarwal A, Tan D, Abraham S, Taggart MW, Wang H, Estrella JS, Zhang M, Rashid A, Maru D. Retrospective Study of Clinicopathologic Features and Patient Outcome of Primary Adenosquamous Carcinoma of the Esophagus. 2015 USCAP Annual Meeting, Boston, MA, 2015. e-Pub 2015.
- Tetzlaff MT, Pattanaprichakul P, Wargo J, Fox P, Patel K, Estrella JS, Broaddus R, Davies MA, Routbort M, Lazar AJ, Prieto VG, W-J H, Gershenwald JE, Woodman S, Torres-Cabala CA, Curry JL. Utility of BRAFV600E Immunohistochemistry (IHC) Expression Pattern as a Surrogate of BRAFV600 Mutation Status in 154 Patients With Advanced Stage Melanoma. 2015 USCAP Annual Meeting, Boston, MA, 2015. e-Pub 2015.
- Charalampakis N, Nogueras-Gonzalez GM, Wang X, Elimova E, Shiozaki H, Wadhwa R, Planjery V, Garris J, Rogers JE, Hiremath A, Blum MA, Lee JH, Bhutani MS, Weston B, Estrella JS, Matamoros A, Das P, Badgwell BD, and Ajani JA. Association of histologic grade and subtypes of gastric cancer (GC) with chemoradiation response. 2015 ASCO MEETING, 2015. e-Pub 2015.
- Wang H, Estrella JS, Chatterjee D, Katz MH, Rashid A, Wang H, Wolff RA, Varadhachary GR, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB. Hepatobiliary/Pancreas Pathology: SY11-3 PANCREATIC DUCTAL ADENOCARCINOMA: NEOADJUVANT THERAPIES AND PATHOLOGY. Pathology 46 Suppl 2:S25, 2014. e-Pub 2014. PMID: 25188109.
- Estrella JS, Tetzlaff MT, Kazen C, Kopetz S, Maru DM, Rashid A, Hamilton SR, Broaddus RR. BRAF V600E Immunohistochemistry in Colorectal Carcinoma. 2014 USCAP Annual Meeting, San Diego, CA, 2014. e-Pub 2014.
- Conte B, George B, Dasari A, Overman MJ, Estrella JS, Jiang Z, Machado K, Mello CL, Ferrarotto R, Hoff PM, Yao JC, Rashid A, and Kopetz S. Colorectal high-grade neuroendocrine carcinoma: A single institution experience. 2014 ASCO MEETING, 2014. e-Pub 2014.
- Roland CL, Kang Y, Chatterjee D, Estrella JS, Rashid A, Lee JE, Yao JC, and Fleming JB. Loss of SMAD4 and effect on overall survival in resected gastrointestinal neuroendocrine tumors. 2014 ASCO MEETING, 2014. e-Pub 2014.
- Estrella JS, Li L, Rashid A, Wang H, Katz MH, Fleming JB, Abbruzzese JL, Wang H. Solid Pseudopapillary Neoplasm of the Pancreas: Clinicopathologic and Survival Analyses of 64 Cases from a Single Institution. 2014 USCAP Annual Meeting, San Diego, CA, 2014. e-Pub 2014.
- Wadhwa R, Elimova E, Sudo K, Shiozaki H, Slack R, Chen HC, Badgwell BD, Matamoros A, Lee JH, Weston B, Bhutani MS, Blum MA, Estrella JS, Das P, and Ajani JA. Outcomes of asymptomatic metastatic gastric cancer (MGC) patients when the initiation of systemic therapy is delayed. 2014 ASCO MEETING, 2014. e-Pub 2014.
- Elimova E, Wadhwa R, Sudo K, Shiozaki H, Slack R, H-C C, Badgwell BD, Matamoros A, Lee JH, Weston B, Bhutani MS, Blum MA, Estrella JS, Das P, and Ajani JA. A phase II study of preoperative chemotherapy and chemoradiation for localized gastric and gastroesophageal junction adenocarcinoma (LGCA). 2014 ASCO MEETING, 2014. e-Pub 2014.
- Estrella JS, Loghavi S, Fuller GN, Ajani JA, Rashid A. FOXP3+ Tumor Infiltrating Lymphocytes in EBV-Positive Lymphoepithelioma-Like Gastric Carcinoma: Clinicopathologic Features and Survival. 2014 USCAP Annual Meeting, San Diego, CA, 2014. e-Pub 2014.
- MA LT, Wang H, Rashid A, Broaddus RR, and Estrella JS. Estrogen-Induced Genes Are Expressed in Pancreatic Neuroendocrine Tumors. Modern Pathology, 2013. e-Pub 2013.
- Taggart MW, Rashid A, Estrella JS, Abraham SC. Serrated Polyps of the Extracolonic Gastrointestinal Tract: Histologic Findings and Genetic Alterations. 101st USCAP Annual Meeting, Vancouver, BC, Canada, 2012. e-Pub 2012.
- Zhao Q, Weng S, Foo W, Estrella JS, Yao JC, Wang H, Wang H, Rashid A. Loss of Expression of DAXX and ATRX in Low-Grade Neuroendocrine Tumors (Carcinoid Tumors). 101st USCAP Annual Meeting, Vancouver, BC, Canada, 2012. e-Pub 2012.
- Estrella JS, Taggart MW, Rashid A, Abraham SC. Low Grade Neuroendocrine Tumors Arising in Intestinal Adenomas: Evidence for Alterations in the Beta-Catenin/APC Pathway. 101st USCAP Annual Meeting, Vancouver, BC, Canada, 2012. e-Pub 2012.
- Estrella JS, Broaddus R, Yao JC, Wang H, Rashid A. Combined Progesterone Receptor and PTEN Expression Predicts Metastasis and Survival in Patients with Pancreatic Neuroendocrine Tumors. 101st USCAP Annual Meeting, Vancouver, BC, Canada, 2012. e-Pub 2012.
- Estrella JS, Rashid A, Fleming JB, Katz MH, Lee JE, Wolf RA, Varadhachary GR, Pisters PWT, Abdalla EK, Vauthey JN, Wang H, Gomez HF, Evans DB, Abbruzzese JL, Wang H. Posttherapy Pathologic Stage and the Number of Positive Lymph Nodes Predict Survival in Patients with Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Chemoradiation. 100th USCAP Annual Meeting, San Antonio, Texas, 2011. e-Pub 2011.
- George B, Estrella JS, Machado KK, Ferrarotto R, Hoff PM, Rashid A, Kopetz S. High-grade neuroendocrine carcinomas (HGNECs) of the colon and rectum: A single-institution retrospective analysis. 2011 ASCO Annual Meeting, 2011. e-Pub 2011.
- Estrella JS, Hofstetter W, Correa A, Ajani J, Swisher S, Rashid A, Maru D. Measurement of Depth of Invasion, Submucosal and Lymphovascular Invasion Predict Lymph Node Involvement in T1 Esophageal Adenocarcinoma. Invasion of Duplicated Muscularis Mucosae Has Similar Risk of Lymph Node Involvement as Mucosal Invasion. 100th USCAP Annual Meeting, San Antonio, Texas, 2011. e-Pub 2011.
- Salvatore, SP, Estrella, JS, Rennert, H, Hoda SA. Infiltrating Pleomorphic Lobular Carcinoma: High Oncotype DX Score Augments Its "Aggressive" Reputation. 99th USCAP Annual Meeting, Washington, DC, 2010. e-Pub 2010.
- Estrella JS, Wu TT, Rashid A, Abraham SC. In Situ Growth of Metastatic Carcinoma to the Gastrointestinal Tract: A Potential Mimic of Primary Neoplasia. 99th USCAP Annual Meeting, Washington, D.C, 2010. e-Pub 2010.
- Estrella JS, Wang H, Taggart MW, Abraham SC, Rashid A. Immunohistochemical Expression of Progesterone Receptor in Neuroendocrine Tumors: Expression is Present Predominately in Well-differentiated Pancreatic Endocrine Neoplasms. 99th USCAP Annual Meeting, Washington, D.C, 2010. e-Pub 2010.
- Estrella JS, Chadwick PA, Campbell JA, Y-T C, Yantiss RK. Immunohistochemical and Molecular Evaluation of Gastric Hyperplastic Polyps. 97th USCAP Annual Meeting, Denver, Colorado, 2008. e-Pub 2008.
Book Chapters
- Estrella JS. Immunohistochemistry. In: Principles of Molecular Diagnostics and Personalized Cancer Medicine. First. Lippincott Williams & Wilkins, 96-102, 2013.
Letters to the Editor
- Badgwell, BD, Estrella, JS, Roy Chowdhuri, S, Ikoma, N, Blum Murphy, M, Ajani, JA, Mansfield, PF. Updated Analysis of a Phase 2 Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Peritoneal Carcinoma from Gastric Cancer. Annals of surgical oncology 31: 2824-2825, 2024.
- Ajani JA, Blum MA, Estrella JS, Das P, Fournier KF. Gatric Cancer: Apples Will Always Be Apples. J Clin Oncol 30: 1017-8; author reply 1019-20, 2012.
Patient Reviews
CV information above last modified March 26, 2026