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Jeffrey E. Lee, M.D.

Present Title & Affiliation

Primary Appointment

Department Chair, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Melanoma and Skin Cancer Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Jeffrey E. Lee is Professor and Chair of the Department of Surgical Oncology as well as Irving and Nadine Mansfield and Robert David Levitt Cancer Research Chair at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr. Lee received his AB from Dartmouth College and his MD from Stanford University School of Medicine. He completed a residency in surgery and a research fellowship in immunology at Stanford, followed by a clinical fellowship in surgical oncology at MD Anderson.  He joined the faculty at MD Anderson in 1993.  Dr. Lee’s clinical interests include the surgical management of patient with melanoma, pancreatic cancer and endocrine tumors.

Prior to assuming his role as Department Chair, Dr. Lee served for 17 years as Medical Director of the Ben Love/El Paso Corporation Melanoma and Skin Center. Dr. Lee is Co-Director of the Melanoma and Skin Cancer Research Program and recently completed a decade as Co-Director of MD Anderson’s NCI-sponsored Melanoma SPORE grant. A particular focus of his research is the role of genetics in melanoma progression. The overall goal of Dr. Lee’s research program has been to identify immune and inflammatory mechanisms controlling melanoma progression to help develop improved treatment strategies. 

Dr. Lee’s laboratory’s prior investigations have identified specific polymorphisms in human leukocyte antigen (HLA) class II as well as blood levels of IL-12, CRP and interferon gamma as independent markers of disease progression and prognosis in melanoma patients. His Melanoma Genetics and Blood Biomarker Program continues to analyze results related to a genome-wide investigation of more than 800,000 single-nucleotide polymorphisms (SNPs) in over 1800 melanoma patients to identify loci most strongly linked with melanoma progression, with plans to use this information to inform comprehensive biologic risk models of melanoma progression that incorporate clinical, histopathologic, serologic, and genetic information.

Office Address

The University of Texas MD Anderson Cancer Center
Department of Surgical Oncology
1400 Pressler Street
Unit Number: 1484
Houston, TX 77030
Room Number: FCT17.6042
Phone: 713-792-7218
Fax: 713-745-5068
Email: jelee@mdanderson.org

Education & Training

Degree-Granting Education

1984 Stanford University School of Medicine, Stanford, CA, MD, Medicine
1979 Dartmouth College, Hanover, NH, BA, Biochemistry

Postgraduate Training

1991-1993 Fellowship, Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Charles M. Balch, M.D.
1990-1991 Chief Resident, General Surgery, Stanford University Medical Center, Stanford, CA, John A. Collins
7/1987-6/1989 Research Fellow, Immunology, Stanford University School of Medicine, Stanford, CA, Alan M. Krensky, M.D.
1984-1990 Resident, General Surgery, Stanford University Medical Center, Stanford, CA, John A. Collins, M.D.
1984-1985 Internship, General Surgery, Stanford University Medical Center, Stanford, CA, John A. Collins, M.D.

Board Certifications

1/1992 American Board of Surgery, Recertification Date: 12/2010

Experience/Service

Other Appointments/Responsibilities

Affiliate Faculty, The University of Texas MD Anderson Cancer Center, Clinical Cancer Genetics Program, Houston, TX, 1990-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Grubbs EG, Lee JE. Walz Aldosteronoma. World J Surg 32(5):854-5, 5/2008. PMID: 18246389.
2. Mittendorf EA, Lim SJ, Schacherer CW, Lucci A, Cormier JN, Mansfield PF, Gershenwald JE, Ross MI, Lee JE. Melanoma adrenal metastasis: natural history and surgical management. Am J Surg 195(3):363-8; discussion 368-9, 3/2008. e-Pub 1/2008. PMID: 18206850.
3. Gonzalez RJ, Tamm EP, Ng C, Phan AT, Vassilopoulou-Sellin R, Perrier ND, Evans DB, Lee JE. Response to mitotane predicts outcome in patients with recurrent adrenal cortical carcinoma. Surgery 142(6):867-75, 12/2007. e-Pub 11/2007. PMID: 18063070.
4. Gonzalez RJ, Shapiro S, Sarlis N, Vassilopoulou-Sellin R, Perrier ND, Evans DB, Lee JE. Laparoscopic resection of adrenal cortical carcinoma: A cautionary note. Surgery 138:1078-1085; discussion 1085-1086, 2005. PMID: 16360394.
5. Pederson LC, Shapiro SE, Fritsche HA, Jr, Delpassand ES, Gagel RF, Sherman SI, Vassilopoulou-Sellin R, Evans DB, Lee JE. Potential role for intraoperative gamma probe identification of normal parathyroid glands. Am J Surg 186:711-7, 12/2003. PMID: 14672784.
6. Pederson LC, Lee JE. Pheochromocytoma. Curr Treat Options Oncol 4(4):329-37, 8/2003. PMID: 12943613.
7. Royal RE, Delpassand ES, Shapiro SE, Fritsche HA, Jr, Vassilopoulou-Sellin R, Sherman SI, Gagel RF, Evans DB, Lee JE. Improving the yield of preoperative parathyroid localization: technetium Tc 99m-sestamibi imaging after thyroid suppression. Surgery 132:968-74; discussion 974-5, 12/2002. PMID: 12490843.
8. Lee JE, Abdalla J, Porter GA, Bradford L, Grimm EA, Reveille JD, Mansfield PF, Gershenwald JE, Ross MI. Presence of the human leukocyte antigen class II gene DRB1*1101 predicts interferon gamma levels and disease recurrence in melanoma patients. Ann Surg Oncol 9(6):587-93. Accompanying editorial: Sondak VK, Chang AE. Melanoma and human leukocyte antigen status: the missing link? Ann Surg Oncol. 2002;9(8):723-724., 7/2002. PMID: 12095976.
9. Lenert JT, Barnett CC, Jr, Kudelka AP, Sellin RV, Gagel RF, Prieto VG, Skibber JM, Ross MI, Pisters PW, Curley SA, Evans DB, Lee JE. Evaluation and surgical resection of adrenal masses in patients with a history of extra-adrenal malignancy. Surgery 130:1060-7, 12/2001. PMID: 11742339.
10. Porter GA, Abdalla J, Lu M, Smith S, Montgomery D, Grimm E, Ross MI, Mansfield PF, Gershenwald JE, Lee JE. Significance of plasma cytokine levels in melanoma patients with histologically negative sentinel lymph nodes. Ann Surg Oncol 8(2):116-22, 3/2001. PMID: 11258775.
11. Barnett CC, Jr, Varma DG, El-Naggar AK, Dackiw AP, Porter GA, Pearson AS, Kudelka AP, Gagel RF, Evans DB, Lee JE. Limitations of size as a criterion in the evaluation of adrenal tumors. Surgery 128:973-82;discussion 982-3, 12/2000. PMID: 11114632.
12. Dackiw AP, Sussman JJ, Fritsche HA, Jr, Delpassand ES, Stanford P, Hoff A, Gagel RF, Evans DB, Lee JE. Relative contributions of technetium Tc 99m sestamibi scintigraphy, intraoperative gamma probe detection, and the rapid parathyroid hormone assay to the surgical management of hyperparathyroidism. Arch Surg 135:550-5; discussion 555-7, 5/2000. PMID: 10807279.
13. Dackiw AP, Cote GJ, Fleming JB, Schultz PN, Stanford P, Vassilopoulou-Sellin R, Evans DB, Gagel RF, Lee JE. Screening for MEN1 mutations in patients with atypical endocrine neoplasia. Surgery 126:1097-103, 12/1999. PMID: 10598193.
14. Lee JE, Evans DB, Hickey RC, Sherman SI, Gagel RF, Abbruzzese MC, Abbruzzese JL. Unknown primary cancer presenting as an adrenal mass: frequency and implications for diagnostic evaluation of adrenal incidentalomas. Surgery 124:1115-22, 12/1998. PMID: 9854592.
15. Lee JE, Curley SA, Gagel RF, Evans DB, Hickey RC. Cortical-sparing adrenalectomy for patients with bilateral pheochromocytoma. Surgery 120:1064-70; discussion 1070-1, 1996. PMID: 8957496.
16. Lee JE, Berger DH, el-Naggar AK, Hickey RC, Vassilopoulou-Sellin R, Gagel RF, Burgess MA, Evans DB. Surgical management, DNA content, and patient survival in adrenal cortical carcinoma. Surgery 118:1090-8, 12/1995. PMID: 7491528.

Invited Articles

1. Raut CP, Lee JE. Unusual functioning endocrine tumors. Curr Treat Options Oncol 4(4):327-334, 2004. PMID: 15233909.

Editorials

1. Lee JE. Predicting the presence of parathyroid carcinoma. Ann Surg Oncol 12:513-514, 2005.

Book Chapters

1. Al-Refaie WB, Lee JE. Vascular resection for pancreatic cancer. In: Pancreatic Cancer. Ed(s) AM Lowy, et al. Springer Science. In Press.
2. Al-Refaie WB, Lee JE. Surgical management of cystic neoplasms of the pancreas. In: Advanced Therapy in Surgical Oncology. Ed(s) Pollock RE, Curley SA, Perrier ND, Ross MI. BC Decker Inc. Hamilton, Ontario, 195-204, 2008.

Letters to the Editor

1. Lee JE. Adjuvant Mitotane in Adrenocortical Carcinoma. N Engl J Med 357(12):1258, 9/2007. PMID: 17891836.

Manuals, Teaching Aids, Other Teaching Publications

1. Gonzalez RJ, Lee JE. Adrenal tumors, Fourth edition. Lippincott Williams and Wilkins: Philadelphia, Pennsylvania, 419-439, 1/2006.

Last updated: 7/1/2015