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Jian Kuang, Ph.D.

Present Title & Affiliation

N/A

Research Interests

The central theme of my research program is to understand the molecular mechanism that controls cell proliferation and transformation. One of the major components in the program is aimed at identifying crucial missing links in the regulatory system that control the G2/M transition in the eukaryotic cell cycle, including previously unrecognized kinases and phosphatases that regulate Cdc25 activation, enzymes that generate and eliminate the mitosis-specific epitope recognized by the monoclonal antibody MPM-2 and the non-Cdc2 components of maturation promoting factor activity.

Office Address

The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 019
Houston, TX 77030
Room Number: Y1.5609
Email: jkuang@mdanderson.com

Education & Training

Degree-Granting Education

1990 The University of Texas-Houston Graduate School of Biomedical Sciences, Houston, TX, PHD, Biochemistry and Cell Biology
1981 Beijing Normal University, Beijing, China, MS, Cell Biology
1977 Beijing Teacher's College, Beijing, China, BS, Biology

Selected Publications

Peer-Reviewed Original Research Articles
1. Zhou X, Pan S, Le S, Corvera J, Lee YC, Lin SH, Kuang J. The CHMP4b and Src docking sites in the Bro1 domain are autoinhibited in the native state of Alix. Biochem J 418(2):277-384, 3/2009. PMID: 19016654.
2. Zhou X, Pan S, Sun L, Corvera J, Lin SH, Kuang J. The HIV-1 p6/EIAV p9 docking site in Alix is autoinhibited as revealed by a conformation-sensitive anti-Alix monoclonal antibody. Biochem J 414(2):215-220, 9/2008. e-Pub 8/2008. PMID: 18476810.
3. Pan S., Wang R., Zhou X., Corvera J., Malgorzata K., Sifers R., Gallick G., Lin SH., Kuang J. Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly. EMBO J 27(15):2077-2090, 7/2008. e-Pub 7/17/2008. PMCID: PMC2516883.
4. Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Stukenbert PT, Kirschner MW, Gallick GE, Kuang J. Regulation of Cdc25C by Erk-MAP kinases during the G2/M transition. Cell 128(6):1119-32, 3/2007. PMID: 17382881.
5. Dejournett RE, Kobayashi R, Pan S, Wu C, Etkin LD, Clark RB, Bogler O, Kuang J. Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins. Biochem J 401(2):521-31, 1/2007. PMCID: PMC1820820.
6. Pan S, Wang R, Zhou X, He G, Koomen J, Kobayashi R, Sun L, Corvera J, Gallick GE, Kuang J. Involvement of the conserved adaptor protein Alix in actin cytoskeleton assembly. J Biol Chem 281(45):34640-50, 11/2006. e-Pub 9/2006. PMID: 16966331.
7. He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobayashi R, Khokhar AR, Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene 24(18):2929-43, 4/2005. PMID: 15735718.
8. Wu Y, Pan S, Luo W, Lin SH, Kuang J. Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells. Oncogene 21(44):6801-8, 10/2002. PMID: 12360406.
9. Kuang J, He G, Huang Z, Khokhar AR, Siddik ZH. Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints. Clin Cancer Res 7(11):3629-39, 11/2001. PMID: 11705886.
10. Wu Y, Pan S, Che S, He G, Nelman-Gonzalez M, Weil MM, Kuang J. Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells. Differentiation 67:139-53, 6/2001. PMID: 11683497.
11. Che S, El-Hodiri HM, Wu CF, Nelman-Gonzalez M, Weil MM, Etkin LD, Clark RB, Kuang J. Identification and cloning of xp95, a putative signal transduction protein in Xenopus oocytes. J Biol Chem 274(9):5522-31, 2/1999. PMID: 10026166.
12. Barratt RA, Kao G, McKenna WG, Kuang J, Muschel RJ. The G2 block induced by DNA damage: a caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation, and H1 kinase activity. Cancer Res 58(12):2639-45, 6/1998. PMID: 9635591.

Grant & Contract Support

Title: RSK2 in Prostate Cancer
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 4/1/2009 - 5/12/2012
 
Title: Design & Development of Agents that Block the Viral Protein Docking Site in Alix
Funding Source: CTT/TI-3D Grants Program
Role: Co-Principal Investigator
Duration: 11/1/2008 - 10/31/2010
 
Title: Characterization of a Cdc25 Activating Protein Kinase Complex
Funding Source: IRG/MDACC
Role: Principal Investigator
Duration: 8/1/2008 - 7/30/2010
 
Title: Checkpoint Response and Platinum Drug Sensitivity
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 5/1/2007 - 2/28/2012

Last updated: 9/8/2009