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Jian Wang, PhD

Present Title & Affiliation

Primary Appointment

Instructor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

My research mainly focuses on development and implementation of innovative statistical methods for cancer data analysis identifying disease-causing or disease-related risk factors. I am also working on development of risk models for cancer assessment and prediction.

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1411
Houston, TX 77030
Room Number: FCT4.6073
Email: jianwang@mdanderson.org

Education & Training

Degree-Granting Education

2007 University of Colorado at Boulder, Boulder, CO, PHD, Statistics
2004 University of Colorado at Boulder, Boulder, CO, MS, Applied Mathematics
2002 Tianjin University, Tianjin, China, MS, Management Sciences
1999 Tianjin University, Tianjin, China, BS, Management Sciences

Experience/Service

Other Appointments/Responsibilities

Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, 11/2007-10/2010
Research Assistant, University of Colorado at Boulder, Boulder, CO, 2004-2007
Teaching Assistant, University of Colorado at Boulder, Boulder, CO, 2002-2007
Research Assistant, Tianjin University, Tianjin, China, 1999-2002

Honors and Awards

2011-2013 Duncan Family Institute Faculty Fellowship Award, UT MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment
2011 Travel Fellowship, International Genetic Epidemiology Society
2011 Travel Support to attend IISA Conference on Probability, Statistics, and Data Analysis, National Science Foundation & National Security Agency
2010 Trainee Research Day Poster Finalist, MD Anderson Cancer Center
2002 Shunchi Awards, Tianjin Shunchi Real Estate Co. Ltd
2000 Honorable Title of Pacesetter on Study of Tianjin University, Tianjin University
1998 Honorable Title of Excellent Student of Tianjin University, Tianjin University
1997-1998 First Class Scholarship of Metrobank Foundation Inc. Philippines, Metrobank Foundation Inc. Philippines
1996 Wang Kechang Scholarship, Wang Kechang Foundation
1995 Honorable Title of Pacesetter on Study of Tianjin University, Tianjin University

Professional Memberships

American Society of Human Genetics
Member, 2008-present
American Statistical Association
Member, 2012-present
International Genetic Epidemiology Society
Professional Member, 2011-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Wang J, Liu E, Luo G. Analysis of time-cost-quality tradeoff optimization in project management. Journal of System Engineering 19:148-154, 2004.
2. Luo G, Liu E, Wang J. Resource planning optimization in network schedule using genetic algorithms. Journal of Tianjin University 37:179-183, 2004.
3. Wang J, Shete S. A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases. Am J Hum Genet 83(1):53-63, 7/2008. e-Pub 6/2008. PMCID: PMC2443842.
4. Wang J, Shete S. Is the tail strength measure more powerful for genetic association test? And tail strength to combine two p-values: their correlation cannot be ignored: Authors reply. Am J Hum Genet 84(2):298-300, 2009. PMCID: PMC2443842.
5. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk. Cancer 116(14):3458-3462, 7/2010. PMCID: PMC3073819.
6. Wang J, Shete S. Using both cases and controls for testing hardy-weinberg proportions in a genetic association study. Hum Hered 69(3):212-218, 2010. e-Pub 3/2010. PMCID: PMC2918648.
7. Wang J, Shete S. A powerful hybrid approach to select top SNPs for genome-wide association study. BMC Genet 12(1):3, 2011. e-Pub 1/2011. PMCID: PMC3024976.
8. Wang J, Shete S. Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. Genet Epidemiol 35(3):190-200, 4/2011. e-Pub 2/2011. PMCID: PMC3063504.
9. Wang J, Shete S. Power and type I error results for a bias-correction approach recently shown to provide accurate odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. Genet Epidemiol 35(7):739-43, 11/2011. e-Pub 7/2011. PMCID: PMC3197800.
10. Huang Z*, Wang J*, Wu CC, Houlston RS, Bondy ML, Shete S. False-Negative-Rate based approach for selecting top single-nucleotide polymorphisms in the first stage of a two-stage genome-wide association study. (* equally contributed). Stat Interface 4(3):359-371, 2011. PMCID: PMC3467022.
11. Wilkinson AV, Bondy ML, Wu X, Wang J, Dong Q, D'Amelio AM, Prokhorov AV, Pu X, Yu RK, Etzel CJ, Shete S, Spitz MR. Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. Cancer Epidemiol Biomarkers Prev 21(1):228-38, 1/2012. e-Pub 10/2011. PMCID: PMC3382046.
12. Wang J, Shete S. Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study. PLoS One 6(11):e27642, 2011. e-Pub 11/2011. PMCID: PMC3215743.
13. Wang J, Shete S. Analysis of secondary phenotype involving the interactive effect of the secondary phenotype and genetic variants on the primary disease. Ann Hum Genet 76(6):484-99, 11/2012. e-Pub 8/2012. PMCID: PMC3472120.
14. Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S. Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk. PLoS One 7(10):e47705, 2012. e-Pub 10/2012. PMCID: PMC3471886.
15. Wilkinson AV, Gabriel KP, Wang J, Bondy ML, Dong Q, Wu X, Shete S, Spitz MR. Sensation seeking genes and physical activity in youth. Genes Brain Behav 12(2):181-8, 3/2013. PMCID: PMC3581711.
16. Reyes-Gibby CC, Wang J, Spitz M, Wu X, Yennurajalingam S, Shete S. Genetic variations in Interleukin-8 and Interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. J Pain Symptom Manage 46(2):161-172, 8/2013. PMCID: PMC3578112.
17. Talluri R, Wang J, Shete S. Calculation of exact p-values when SNPs are tested using multiple genetic models. BMC Genet 15(1):75, 6/2014. PMCID: PMC4076502.
18. Wang J, Yu R, Shete S. Comparison of multilevel model and the family-based association test (FBAT) for identifying SNPs associated with systolic and diastolic blood pressure using GAW18 simulated data. BMC Proceedings 8(Suppl):S30, 6/2014.
19. Archer NP, Wilkinson AV, Ranjit N, Wang J, Zhao H, Swann AC, Shete S. Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. Brain Behav 4(4):521-30, 7/2014. e-Pub 5/2014. PMCID: PMC4128034.
20. Wang J, Yu R, Shete S. X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation. Genet Epidemiol 38(6):483-93, 9/2014. e-Pub 7/2014. PMCID: PMC4127090.
21. Reyes-Gibby CC, Yuan C, Yeung SC, Wang J, Shete S. Gene network analysis shows immune-signaling and ERK1/2 as potential therapeutic targets for multiple addiction phenotypes: Alcohol, Smoking and Opioid Addiction. Submitted.

Abstracts

1. Wang J, Yu R, Shete S. A unified analysis approach for X-chromosome that accounts for random, skewed and escaping of X-chromosome inactivation. The 64th Annual Meeting of the American Society of Human Genetics, 10/2014.
2. Yuan C, Wang J, Shete S, Reyes-Gibby C. Bioinformatics and opioid addiction: gene network analysis. CPRIT Summer Program, MD Anderson Cancer Center, 8/2014.
3. Strong L, Wang J, Christie I, Regan S, Franzini L, Wetter D, Reitzel L, McNeill L. Pathways linking neighborhood socioeconomic context to self-rated health in African Americans in Houston, TX. 141st Annual Meeting and Exposition of American Public Health Association, 11/2013.
4. Wang J, Yu R, Shete S. X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escaping of X-inactivation. 22nd Annual Meeting of International Genetic Epidemiology Society, 9/2013.
5. Christie IC, Strong LL, Regan SD, Wang J, Reitzel LR, Wetter DW, McNeill LH. Multiple Factors of Neighborhood Deprivation Differentially Predict Physical Health in a Large African American Sample. 71st Annual Scientific Meeting of American Psychosomatic Society, 3/2013.
6. Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S. Multiple mediation analysis in case-control studies: application to detecting joint mediating effects of smoking and chronic obstructive pulmonary disease on the association between CHRNA5-A3 genetic locus and lung cancer risk. The 62nd Annual Meeting of the American Society of Human Genetics, 11/2012.
7. Wang J, Yu RK, Shete S. Comparison of multilevel model and the family-based association test (FBAT) for identifying SNPs associated with systolic and diastolic blood pressure using GAW18 simulated data. Genetic Analysis Workshop 18, 10/2012.
8. Yu RK, Wang J, Shete S. Family-based association test of hypertension among Mexican American. Genetic Analysis Workshop 18, 10/2012.
9. Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S. Method to analyze multiple mediators in case-control studies with application to detecting mediating effects of smoking and chronic obstructive pulmonary disease on the association between CHRNA5-A3 genetic locus and lung cancer risk. 21st Annual Meeting of International Genetic Epidemiology Society, 10/2012.
10. Wang J, Shete S. Selection of top SNPs for genome-wide association study using p values and magnitude of odds ratios. The 61st Annual Meeting of the American Society of Human Genetics, 10/2011.
11. Wang J, Shete S. Selection of top SNPs for genome-wide association study using p values and magnitude of odds ratios. 20th Annual Meeting of International Genetic Epidemiology Society, 9/2011.
12. Wang J, Shete S. Estimation of odds ratio of genetic variants for secondary phenotype associated with primary disease. 2011 IISA Conference on Probability, Statistics, and Data Analysis, 4/2011.
13. Wang J, Shete S. Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. 19th Annual Meeting of International Genetic Epidemiology Society, 10/2010.
14. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive airway disease on the relationship between the CHRNA5-A3 genetic locus and lung cancer risk. Trainee Research Day Poster Finalist, MD Anderson Cancer Center, 5/2010.
15. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive airway disease on the relationship between the CHRNA5-A3 genetic locus and lung cancer risk. 59th Annual Meeting of the American Society of Human Genetics, 10/2009.
16. Wang J, Shete S. A test for genetic association that incorporates information from population genetics. 58th Annual Meeting of the American Society of Human Genetics, 11/2008.

Book Chapters

1. Wang J, Shete S. Testing departure from Hardy-Weinberg proportions. In: Methods Mol Biol. 850. Ed(s) Elston R, Satagopan J, Sun S. Humana Press: USA, 77-102, 2012. ISBN: 22307695.

Manuals, Teaching Aids, Other Teaching Publications

1. Shaw J, Csibrik K, Wang J, Tang Y, Ramos E. Impacts of Slow the Flow Colorado on outdoor water use. Center for ReSource Conservation: Boulder, CO, 2007.
2. Wang J. Recovering Bayesian networks with applications to gene regulatory networks. University of Colorado at Boulder: Boulder, CO, 2007.
3. Baker A, Jung M, Lee C, Maslova I, Morton M, Wang J. Analysis of biological interaction networks for drug discovery. Proceedings of 12th Industrial Mathematical & Statistical Modeling Workshop: Raleigh, NC, 119-157, 2006.
4. Liu EL, Wang J, Luo G. Project bidding decision based on fuzzy logic. International Conference on Modern Industrial Engineering and Engineering Management in New Century: Tianjin, 694-701, 8/2001.
5. Liu EL, Lu LN, Luo G, Wang J. The application of decision-making to bid under risks. International Conference on Modern Industrial Engineering and Engineering Management in New Century: Tianjin, 691-694, 8/2001.

Grant & Contract Support

Title: Risk Modeling Using Mediation Analysis and Bayesian Network Recovery with Application to Smoking Cessation Study
Funding Source: Duncan Family Institute
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2013
 
Title: The Meningioma Consortium: Genome-Wide Association Study
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Bondy
Duration: 7/1/2010 - 6/30/2011
 
Title: Genome-Wide Association Study of Head and Neck Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Sanjay Shete
Duration: 3/1/2009 - 11/30/2011

Last updated: 10/27/2014