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Jianjun Gao, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1155 Pressler St.
Unit Number: 1374
Houston, TX 77030
Room Number: CPB7.3510
Phone: 713-792-2830
Fax: 713-745-1625

Education & Training

Degree-Granting Education

2006 University of Kansas School of Medicine, Kansas City, KS, MD, Medicine
1997 University of Kansas, Kansas City, KS, PHD, Molecular Immunology
1993 Fudan University, China, MS Candidate, Genetics
1990 Nanjing Normal University, China, BS, Biology

Postgraduate Training

7/2010-6/2013 Clinical Fellowship, Medical Oncology, UT MD Anderson Cancer Center, Houston, TX
7/2006-2/2010 Clinical Residency, Internal Medicine, University of Wisconsin, Madison, WI

Board Certifications

2011 American Board of Internal Medicine
2006 Wisconsin Physician License

Honors and Awards

2014 American Society of Clinical Oncology Career Development Award (returned due to concurrent NIH K-12 award)
2013 MD Anderson Cancer Center Bladder Cancer SPORE Career Development Award, MD Anderson Cancer Center
2013 MD Anderson Division of Cancer Medicine Hematology/Oncology Fellowship Program Achievement in Basic Science Research Award
2013 Stand Up To Cancer and the Cancer Research Institute Young Investigator Award
2013 The Paul Calabresi Clinical Oncology (NCI K-12) Award, NCI
2013 The Sheikh Khalifa Bin Zayed Al Nahyan Scholar and Fellow, MD Anderson Cancer Center
2013 The William L. Pippin Jr. Fellowship Award in Genitourinary Cancer Research
2012 American Association of Cancer Research Aflac Scholar-in-Training Award
2012 American Association of Cancer Research Highly Ranked Abstract Award
2012 American Society of Clinical Oncology Young Investigator Award
2012 National Institute of Health Loan Repayment Award
2012 Texas Society of Clinical Oncology Award of Excellence
2012 The Lupe C. Garcia Fellowship Award in Cancer Research
2011 Americn Society of Clinical Oncology Merit Award
2011 MD Anderson Cancer Center NIH T32 Trainee Award
2006 Helmuth Sprinz Award, University of Kansas Medical Center (KUMC)
2006 KUMC The Person Who Best Exemplifies the Attributes You Want in a Physician Award
2004 KUMC Doctor's Doctor Award
2003 KUMC Most Valuable Player of the Class Award
2003 National Institute of Health New Investigator Award
2002 University of Kansas Cultural Diversity Scholarship
2001 American Heart Association Beginning-Grant-in-Aid
1997 Kansas Health Foundation Fellowship Award

Selected Publications

Peer-Reviewed Original Research Articles

1. Bilen MA, Subudhi SK, Gao J, Tannir NM, Tu SM, Sharma P. Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody. J Immunother Cancer 4:36, 2016. e-Pub 6/21/2016. PMCID: PMC4915058.
2. Gao J, He Q, Subudhi S, Aparicio A, Zurita-Saavedra A, Lee DH, Jimenez C, Suarez-Almazor M, Sharma P. Review of Immune-Related Adverse Events in Prostate Cancer Patients Treated with Ipilimumab: MD Anderson Experience. Oncogene 34(43):5411-7, 10/2015. e-Pub 2/9/2015. PMCID: PMC4530091.
3. Liu XD, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, Ding Z, Zhang X, Bai S, German P, Tamboli P, Rao P, Karam JA, Wood C, Matin S, Zurita A, Bex A, Griffioen AW, Gao J, Sharma P, Tannir N, Sircar K, Jonasch E. Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma. Cancer Immunol Res 3(9):1017-29, 9/2015. e-Pub 5/26/2015. PMCID: PMC4561186.
4. Malouf GG, Su X, Yao H, Gao J, Xiong L, He Q, Compérat E, Couturier J, Molinié V, Escudier B, Camparo P, Doss DJ, Thompson EJ, Khayat D, Wood CG, Yu W, Teh BT, Weinstein J, Tannir NM. Next-generation sequencing of translocation renal cell carcinoma reveals novel RNA splicing partners and frequent mutations of chromatin-remodeling genes. Clin Cancer Res 20(15):4129-40, 8/1/2014. e-Pub 6/4/2014. PMCID: PMC4167829.
5. Chen H, Fu T, Suh WK, Tsavachidou D, Wen S, Gao J, Ng Tang D, He Q, Sun J, Sharma P. CD4 cells require ICOS-mediated P13K-signaling to increase T-bet expression in the setting of anti-CTLA therapy. Cancer Immunol Res 2(2):167-76, 2/2014. e-Pub 11/19/2013. PMCID: PMC4004958.
6. Gou HF, Li X, Qiu M, Cheng K, Li LH, Dong H, Chen Y, Tang Y, Gao F, Zhao F, Men HT, Ge J, Su JM, Xu F, Bi F, Gao JJ, Liu JY. Epidermal growth factor receptor (EGFR)-RAS signaling pathway in penile squamous cell carcinoma. PLoS One 8(4):e62175, 2013. e-Pub 4/24/2013. PMCID: PMC3634795.
7. Gao JJ, Maricque BB, Morse MD, Huang W, McNeel DG. Identification of autoantibodies in a patient with testicular cancer and concurrent inflammatory bowel disease. J Clin Oncol 28(33):e680-3, 11/20/2010. e-Pub 8/30/2010. PMID: 20805455.
8. Gao JJ, Shen J, Kolbert C, Raghavakaimal S, Papasian CJ, Qureshi AA, Vogel SN, Morrison DC, Qureshi N. The proteasome regulates bacterial CpG DNA-induced signaling pathways in murine macrophages. Shock 34(4):390-401, 10/2010. PMCID: PMC2943147.
9. Shen J, Gao JJ, Zhang G, Tan X, Morrison DC, Papasian C, Vogel SN, Qureshi N. Proteasome-mediated regulation of CpG DNA- and peptidoglycan-induced cytokines, inflammatory genes, and mitogen-activated protein kinase activation. Shock 25(6):594-9, 6/2006. PMID: 16721267.
10. Lei MG, Gao JJ, Morrison DC, Qureshi N. Pathogenesis of sepsis: current concepts and emerging therapies. Mo Med 100(5):524-9, Sep-Oct, 9/2003. PMID: 14601445.
11. Gao JJ, Diesl V, Wittmann T, Morrison DC, Ryan JL, Vogel SN, Follettie MT. Bacterial LPS and CpG DNA differentially induce gene expression profiles in mouse macrophages. J Endotoxin Res 9(4):237-43, 2003. PMID: 12935354.
12. Papasian CJ, Silverstein R, Gao JJ, Bamberger DM, Morrison DC. Anomalous role of tumor necrosis factor alpha in experimental enterococcal infection. Infect Immun 70(12):6628-37, 12/2002. PMID: 12438335.
13. Gao JJ, Diesl V, Wittmann T, Morrison DC, Ryan JL, Vogel SN, Follettie MT. Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide. J Leukoc Biol 72(6):1234-45, 12/2002. PMID: 12488506.
14. Gao JJ, Xue Q, Papasian CJ, Morrison DC. Bacterial DNA and lipopolysaccharide induce synergistic production of TNF-alpha through a post-transcriptional mechanism. J Immunol 166(11):6855-60, 6/2001. PMID: 11359845.
15. Chi L, Li Y, Stehno-Bittel L, Gao J, Morrison DC, Stechschulte DJ, Dileepan KN. Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha. J Interferon Cytokine Res 21(4):231-40, 4/2001. PMID: 11359654.
16. Gao JJ, Xue Q, Zuvanich EG, Haghi KR, Morrison DC. Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro. Infect Immun 69(2):751-7, 2/2001. PMCID: PMC97948.
17. Gao JJ, Filla MB, Lorsbach RB, Pace JL, Crespo A, Russell SW, Murphy WJ. Prolonged exposure of mouse macrophages to IFN-beta suppresses transcription of the inducible nitric oxide synthase gene: altered availability of transcription factor Stat1alpha. Eur J Immunol 30(6):1551-61, 6/2000. PMID: 10898490.
18. Chu W, Gao J, Murphy WJ, Hunt JS. A candidate interferon-gamma activated site (GAS element) in the HLA-G promoter does not bind nuclear proteins. Hum Immunol 60(11):1113-8, 11/1999. PMID: 10600009.
19. Gao JJ, Zuvanich EG, Xue Q, Horn DL, Silverstein R, Morrison DC. Cutting edge: bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J Immunol 163(8):4095-9, 10/1999. PMID: 10510342.
20. Gao JJ, Filla MB, Fultz MJ, Vogel SN, Russell SW, Murphy WJ. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol 161(9):4803-10, 11/1998. PMID: 9794412.
21. Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ. An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem 272(2):1226-30, 1/1997. PMID: 8995425.

Invited Articles

1. Siefker-Radtke AO, Gao J. Towards effective adjuvant treatment for urothelial cancer. Lancet Oncol 16(1):9-10, 1/2015. e-Pub 12/11/2014. PMID: 25498220.
2. Jonasch E, Gao J, Rathmell WK. Renal cell carcinoma. BMJ 349(10):g4797, 2014. e-Pub 11/10/2014. PMCID: PMC4707715.
3. Gao J, Bernatchez C, Sharma P, Radvanyi LG, Hwu P. Advances in the development of cancer immunotherapies. Trends Immunol 34(2):90-8, 2/2013. e-Pub 9/30/2012. PMCID: PMC3565019.
4. Lizée G, Overwijk WW, Radvanyi L, Gao J, Sharma P, Hwu P. Harnessing the power of the immune system to target cancer. Annu Rev Med 64:71-90, 2013. e-Pub 10/22/2012. PMID: 23092383.


1. Gao J, Chen H, Ng Tang D, Sharma P. Investigating genes and micro-RNAs that my predict clinical benefits of anti-CTLA-4 therapy. J Clin Oncol (#3043), 2013.
2. Gao JJ, Sun J, Ward J, Rao P, Troncoso P, Araujo J, Tang DN, Chen H, Thall P, Wen S, Sharma P. Combination therapy with anti-CTLA-4 plus leuprolide acetate in the pre-surgical setting of patients with regional, high-risk prostate cancer. Proceedings American Association Cancer Research (#2635), 2012.
3. Choi H, mcAuliffe JC, Boonsirikamchai P, Gao JJ, Charnsangavej C, Reynosa DG. Exploration of the Molecular Mechanism of CT Evidence of Response to Imatinib in Gastrointestinal Stromal Tumors. RSNA (#SSG05-03), 2011.
4. Gao JJ. Mechanism of early radiographic response to imatinib in GIST. J Clin Oncol (#10049), 2011.

Book Chapters

1. Shnyra A, Luchi M, Gao JJ et al. Endotoxin in human disease and its endogenious control. In: Multiple Organ Failure. Ed(s) A Baue, E Faist, D. Fry. Springer-Verlag New York Inc. New York, 114-130, 2000.

Last updated: 9/6/2016