Jiusheng Yan, PhD
Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine
About Dr. Jiusheng Yan
Present Title & Affiliation
Primary Appointment
Associate Professor, Anesthesiology & PeriOper Med, The University of Texas MD Anderson Cancer Center, Houston, Texas
Regular Faculty Member, Neuroscience, Molecular & Translational Biology, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX
Research Interests
Ion channels are integral membrane proteins that control cellular ionic homeostasis and electric signaling. By gating (opening and closing) their pores that are selectively permeable to different ions across membrane, ion channels are involved in nearly all fundamental cellular and physiological processes. As one of the few most tractable protein classes, ion channels have long been key targets in pharmaceutical drug development for excitable cells-related treatments and diseases including anesthesia and neurological, cardiovascular and muscular disorders. Ion channels are currently targets of ~ 20% approved drugs for human diseases and are recently emerging as biomarkers and therapeutic targets for many nonexcitable cells-related diseases including cancer. The overall long-term goal of my research is to identify novel protein targets, molecular mechanisms, and drugs or molecular agents that are suitable for ion channel-targeted therapeutic intervention in cancer and neurological conditions and diseases including anesthesia, pain, and chemotherapy-induced fatigue, cognitive dysfunction, and neuropathy. To achieve this goal, my research focuses on: 1) identification and structural/functional characterization of novel regulatory auxiliary proteins of ion channels; 2) determination of the biochemical and biophysical mechanisms of ion channel gating processes and regulation by novel auxiliary proteins or modulators; and 3) development of novel drugs or molecular agents for ion channel-targeted therapy.
Education & Training
Degree-Granting Education
| 2004 | Purdue University, West Lafayette, Indiana, US, Ph.D. in Biochemistry & Molecular Biology |
| 2000 | Institute of Botany, Chinese Academy of Sciences, Beijing, CN, M.S. in Botany |
| 1996 | Wuhan University, Wuhan, CN, BS in Biology |
Postgraduate Training
| 2007-2010 | Postdoctoral Research Fellow, University of Texas at Austin, Austin, Texas |
| 2005-2007 | Postdoctoral Research Fellow, University of California at Davis, Davis, California |
| 2005-2005 | Postdoctoral Research Fellow, Purdue University, West Lafayette, Indiana |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Anesthesiology and Perioperative Medicine - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2019
Research Associate, Neurobiology, School of Biological Sciences, The University of Texas at Austin, Austin, Texas, 2010 - 2012
Intramural Institutional Committee Activities
Member, Institutional Animal Care and Use Committee (IACUC), The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Admissions Committee of Molecular & Translational Biology Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, 2021 - Present
Member, Faculty Search Committee - Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center, 2019 - Present
Member, Advisory Committee (PhD student, Nabina Paudyal), The University of Texas MD Anderson Cancer Center, 2018 - 2021
Member, Clinical Research Committee - Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, 2017 - Present
Member, Executive Committee of The Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, 2015 - 2017
Reviewer, Internal Review Study Section, The University of Texas MD Anderson Cancer Center, 2015 - 2016
Member, Institutional Biosafety Committee, The University of Texas MD Anderson Cancer Center, 2013 - 2016
Reviewer, Endowed Fellowship Awards, The University of Texas MD Anderson Cancer Center, 2013 - 2013
Editorial Activities
Review Editor, Frontiers in Physiology, 2022 - Present
Associate Editor, Frontiers in Molecular Neuroscience, 2022 - Present
Review Editor, Frontiers in Molecular Neuroscience, 2018 - 2022
Honors & Awards
| 2022 | Top Publication Award, Division of Anesthesiology, Critical Care & Pain Medicine |
| 2008 | AHA Postdoctoral Fellowship, American Heart Association |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2015. The single transmembrane domain determines function of BK channel γ1 subunit. Poster. 2015 Translational Pain Research Colloquium. Houston, TX, US.
- 2015. A shared mechanism of BK channel activation by mallotoxin and auxiliary 1 subunit. Poster. 2015 Translational Pain Research. Houston, TX, US.
- 2015. NMDA receptors and BK channels form Ca2+ signaling complexes in brain. Poster. 2015 Translational Pain Research Colloquium. Houston, TX, US.
- 2014. Identification of Key Protein Regions for the BK Channel gamma-Subunits’ Superior Activating Potency. Poster. Fifth Annual Translational Pain Research Symposium. Houston, TX, US.
Regional Presentations
- 2020. NAADP-evoked calcium signaling: the search for a receptor. Invited. The University of Texas Health Science Center. Houston, TX, US.
- 2019. BK Channel Regulation by Auxiliary Subunits and NMDA Receptors. Invited. UT Southeastern Medical Center. Dallas, TX, US.
- 2013. Regulation of calcium-activated potassium channels by auxiliary proteins. Invited. University of Texas Health Science Center. Houston, TX, US.
- 2012. Structural diversity of BK potassium channels. Invited. University of Texas Health Science Center. Houston, TX, US.
National Presentations
- 2025. Regulation of LRRC8 Channels and Pain by NPEPPS. Poster. Ion Channel Regulation -FASEB. Southbridge, Massachusetts, US.
- 2024. NAADP-Evoked Sodium Currents of Two-Pore Channels Mediated by Lsm12 and PI(3,5)P2. Poster. Biophysical Society 68th Annual Meeting (2024). Philadelphia, Pennsylvania, US.
- 2024. ON THE LOCALIZATION & COMPOSITION OF BK CHANNEL PORE GATE: SELECTIVITY FILTER VS LIPID OCCLUSION OF DEEP PORE. Poster. Biophysical Society 68th Annual Meeting (2024). Philadelphia, Pennsylvania, US.
- 2023. Mice with LRRC26-mediated hyperactivity of BK channels in the forebrain exhibited locomotor hyperactivity and cognitive defects resembling ADHD. Poster. Neuroscience 2023 - Society for Neuroscience. Washington DC, US.
- 2022. NOVEL CONCATENATED TANDEM CONSTRUCTS REVEAL 3 DISTINCT TYPES OF SUBUNIT STOICHIOMETRY IN BK CHANNEL MODULATION. Poster. Biophysical Society 66th Annual Meeting (2022). San Francisco, US.
- 2022. LSM12, AN NAADP RECEPTOR, IS ALSO A PI(3,5)P2-COMPETITIVE ANTAGONIST OF HUMAN TWO PORE CHANNELS. Poster. Biophysical Society 66th Annual Meeting (2022). San Francisco, US.
- 2021. Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles. Poster. Biophysical Society 65th Annual Meeting (2021), US.
- 2021. A PIKfyve inhibitor, YM201636, directly inhibits human TPC2 channel. Poster. Biophysical Society 65th Annual Meeting (2021), US.
- 2021. BK channel modulation by the -subunit positively charged peptides via electrostatic interactions with the calcium-bowl site. Poster. Biophysical Society 65th Annual Meeting (2021), US.
- 2019. IDENTIFICATION AND CHARACTERIZATION OF AN NAADP RECEPTOR ESSENTIAL FOR NAADP-EVOKED CALCIUM RELEASE FROM ENDOLYSOSOMAL ORGANELLES. Poster. Biophysical Society 63rd Annual Meeting (2019). Baltimore, MD, US.
- 2018. Regulation of BK channel auxiliary gamma subunits by N-glycosylation. Poster. Biophysical Society 62nd Annual Meeting (2018). San Francisco, CA, US.
- 2018. Quantitative proteomic analysis of the putative NAADP-TPC signaling complex. Poster. Biophysical Society 62nd Annual Meeting (2018). San Francisco, CA, US.
- 2017. BK channels are structurally and functionally coupled with NMDA receptors and postsynaptically regulate synaptic transmission and plasticity. Poster. Neuroscience 2017. Washington DC, US.
- 2017. Functional coupling of BK channels to NMDA receptors in hippocampal dentate gyrus. Poster. Biophysical Society 61st Annual Meeting (2017). New orleans, LA, US.
- 2016. A critical role of the S6 transmembrane helix in BK channel modulation by auxiliary gamma subunits. Poster. Biophysical Society 60th Annual Meeting (2016). Los Angeles, CA, US.
- 2016. A shared mechanism of BK channel activation by mallotoxin and auxiliary gamma1 subunit. Poster. Biophysical Society 60th Annual Meeting (2016). Los Angeles, CA, US.
- 2016. Structural and functional coupling between BK channels and NMDA receptors. Poster. Biophysical Society 60th Annual Meeting (2016). Los Angeles, CA, US.
- 2015. The modulatory function of the BK channel γ1 subunit is determined by its transmembrane domain. Poster. Biophysical Society 59th Annual Meeting (2015). Baltimore, MD, US.
- 2014. Structural Determinant for the BK Channel gamma-Subunits’ Superior Activating Potency. Poster. Gordon Research Conferences (Ion Channels - The Molecular Basis of Excitability and Disease). South Hadley, MA, US.
- 2014. CHARGED RESIDUES ON THE INTRACELLULAR INTERSUBUNIT ASSEMBLY INTERFACE CONTRIBUTE TO CALCIUM-SENSITIVITY OF BK CHANNELS. Poster. Biophysical Society 58th Annual Meeting (2014). San Francisco, CA, US.
- 2014. CLOSED STATE COUPLED C-TYPE INACTIVATION IN BK CHANNELS. Invited. Biophysical Society 58th Annual Meeting (2014). San Francisco, CA, US.
- 2014. STRUCTURAL DETERMINANTS OF THE BK CHANNEL γ-SUBUNITS’ MODULATORY POTENCY. Poster. Biophysical Society 58th Annual Meeting (2014). San Francisco, CA, US.
- 2012. BK channel modulation by leucine-rich repeat containing proteins. Poster. Biophysical Society 56th Annual Meeting (2012). San Diego, CA, US.
- 2010. A novel auxillary protein allows BK potassium channel activation at resting voltage without calcium. Poster. Biophysical Society 54th Annual Meeting (2010). San Francisco, CA, US.
- 2007. Poster, Tuning of BK channels by phosphorylation in rat brain. Poster. Neuroscience 2007. San Diego, CA, US.
- 2004. Analysis of the x-ray structure of the cytochrome b6f complex: Distribution of quinone-analogue inhibitor binding sites. Poster. The 30th Midwest Photosynthesis Meeting. Turkey Run State Park, IN, US.
- 2003. Electron transfer between the Rieske iron-sulfer protein and cytochrome f in the spinach cytochrome b6f complex induced by pH jump. Poster. The 29th Midwest Photosynthesis Meeting. Turkey Run State Park, IN, US.
- 2003. Poster, Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein. Poster. Gordon Research Conferences in Photosynthesis. Bristol, RI, US.
- 2003. Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein. Poster. Experimental Biology 2003. San Diego, CA, US.
- 2002. Electron transfer via rotation-translation of the Rieske iron-sulfer protein: A different perspective. Poster. The 28th Midwest Photosynthesis Meeting. Turkey Run State Park, IN, US.
- 2002. Electron transfer via rotation-translation of the Rieske iron-sulfur protein: A different perspective. Poster. Eight Annual Purdue University Biophysics Symposium. West Lafayette, IN, US.
- 2002. Mutational analysis of the linker region of the Rieske iron-sulfer protein in synechococcus sp. PCC 7002. Poster. Gordon Research Conferences in Photosynthesis (Roger Wiliams University). Bristol, RI, US.
International Presentations
- 2024. Crosstalk between NAADP and PI(3,5)P2 signaling mediated by Lsm12 and two-pore channels. Invited. 17th International Meeting of the European Calcium Society. Cambridge, GB.
- 2021. Lsm12 as an NAADP receptor protein mediating calcium. Invited. European Calcium Society: Special Session on NAADP Signaling. London, GB.
- 2015. Molecular structural determinants of BK channel γ subunits. Invited. The 5th International Ion Channel Conference. Luzhou, CN.
- 2004. Molecular control of a bimodal distribution of quinone-analogue inhibitor binding sites in the cytochrome b6f complex. Poster. 13th International Congress on Photosynthesis. Montreal, CA.
Grant & Contract Support
| Date: | 2024 - 2025 |
| Title: | BK channel regulation by auxiliary LRR proteins |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | PI |
| ID: | Bridge Fund |
| Date: | 2023 - 2025 |
| Title: | Molecular basis of the NAADP-gated calcium release channel complexes - Equipment Supplement |
| Funding Source: | NIGMS |
| Role: | PI |
| ID: | 3R01GM130814-06S1 |
| Date: | 2023 - 2024 |
| Title: | Molecular basis of the NAADP-gated calcium release channel complexes |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | PI |
| ID: | Bridge Fund |
| Date: | 2022 - 2026 |
| Title: | Molecular basis of the NAADP-gated calcium release channel complexes |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | 2R01GM130814-05 |
| Date: | 2018 - 2022 |
| Title: | Molecular basis of the NAADP-gated calcium release channel complexes |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | 1-R01-GM130814-01 |
| Date: | 2018 - 2023 |
| Title: | BK channel regulation by auxiliary LRR proteins |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 2-R01-NS078152-06A1 |
| Date: | 2018 - 2022 |
| Title: | Pore Gating Mechanisms of BK Channels |
| Funding Source: | NIH/NIGMS |
| Role: | Co-PI |
| ID: | 1-R01-GM127332-01 |
| Date: | 2016 - 2019 |
| Title: | Identification of Novel Protein Important for NAADP-Evoked Calcium Signaling |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1-R21-NS096296-01A1 |
| Date: | 2012 - 2017 |
| Title: | BK channel regulation by auxillary LRR proteins |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1-R01NS078152-01 |
| Date: | 2012 - 2017 |
| Title: | Start-up fund |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | PI |
| ID: | Institutional Start-up Fund |
| Date: | 2011 - 2014 |
| Title: | Delineation of a LRR family of BK channel auxillary subunits |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1-R21NS075118-01 |
| Date: | 2008 - 2010 |
| Title: | NO TITLE PROVIDED |
| Funding Source: | American Heart Association |
| Role: | PI |
| ID: | 0825302F |
Selected Publications
Peer-Reviewed Articles
- Chen G, Li Q, Shah K, Yan J. Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter. eLife. e-Pub 2025.
- Chen G, Guan X, Cai Y, Pan Z, Pan HL, Yan J. Transgenic expression of BK channel auxiliary LRRC26 subunit in the forebrain causes locomotor hyperactivity and cognitive defects. eNeuro. e-Pub 2025.
- Zhou MH, Chen SR, Jin D, Huang Y, Chen H, Chen G, Yan J, Pan HL. Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity, 2025. PMID: 41129242.
- Li Q, Chen G, Yan J. Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels. Biophys J 123(14):2154-2166, 2024. e-Pub 2024. PMID: 38637987.
- Chen G, Li Q, Webb TI, Hollywood MA, Yan J. BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site. J Gen Physiol 155(6), 2023. e-Pub 2023. PMID: 37130264.
- Du C, Guan X, Yan J. Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance. Commun Biol 5(1):738, 2022. e-Pub 2022. PMID: 35871252.
- Chen G, Li Q, Yan J. The leucine-rich repeat domains of BK channel auxiliary γ subunits regulate their expression, trafficking, and channel-modulation functions. J Biol Chem 298(3):101664, 2022. e-Pub 2022. PMID: 35104503.
- Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS. State-dependent inhibition of BK channels by the opioid agonist loperamide. J Gen Physiol 153(9), 2021. e-Pub 2021. PMID: 34357374.
- Zhang J, Guan X, Shah K, Yan J. Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles. Nat Commun 12(1):4739, 2021. e-Pub 2021. PMID: 34362892.
- Zhou MH, Chen SR, Wang L, Huang Y, Deng M, Zhang J, Zhang J, Chen H, Yan J, Pan HL. Protein Kinase C-Mediated Phosphorylation and α2δ-1 Interdependently Regulate NMDA Receptor Trafficking and Activity. J Neurosci 41(30):6415-6429, 2021. e-Pub 2021. PMID: 34252035.
- Erasso D, Tender GC, Li Q, Yan J, Culicchia F, Abdi S, Cui J. The Effects of Agrin Isoforms on Diabetic Neuropathic Pain in a Rat Streptozotocin Model. Anesth Analg 127(4):1051-1057, 2018. e-Pub 2018. PMID: 29369095.
- Zhang J, Guan X, Li Q, Meredith AL, Pan HL, Yan J. Glutamate-activated BK channel complexes formed with NMDA receptors. Proc Natl Acad Sci U S A 115(38):E9006-E9014, 2018. e-Pub 2018. PMID: 30181277.
- Li Q, Li Y, Wei H, Pan HM, Vouga AG, Rothberg BS, Wu Y, Yan J. Molecular determinants of Ca2+sensitivity at the intersubunit interface of the BK channel gating ring. Sci Rep 8(1):509, 2018. e-Pub 2018. PMID: 29323236.
- Guan X, Li Q, Yan J. Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. Sci Rep 7:42240, 2017. e-Pub 2017. PMID: 28165042.
- Kshatri AS, Li Q, Yan J, Large RJ, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA. Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels. Channels (Austin) 11(1):66-78, 2017. e-Pub 2017. PMID: 27440457.
- Yan J, Li Q, Aldrich RW. Closed state-coupled C-type inactivation in BK channels. Proc Natl Acad Sci U S A 113(25):6991-6, 2016. e-Pub 2016. PMID: 27298368.
- Li Q, Guan X, Yen K, Zhang J, Yan J. The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit. J Gen Physiol 147(4):337-51, 2016. e-Pub 2016. PMID: 27022192.
- Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q, Kosturakis AK, Cassidy RM, Harrison DS, Cata JP, Sapire K, Zhang H, Kennamer-Chapman RM, Jawad AB, Ghetti A, Yan J, Palecek J, Dougherty PM. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci 35(39):13487-500, 2015. e-Pub 2015. PMID: 26424893.
- Li Q, Fan F, Kwak HR, Yan J. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits. J Gen Physiol 145(6):543-54, 2015. e-Pub 2015. PMID: 26009545.
- Chen X, Yan J, Aldrich RW. BK channel opening involves side-chain reorientation of multiple deep-pore residues. Proc Natl Acad Sci U S A 111(1):E79-88, 2014. e-Pub 2014. PMID: 24367115.
- Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X. Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A 110(43):17284-9, 2013. e-Pub 2013. PMID: 24101509.
- Yan J, Aldrich RW. BK potassium channel modulation by leucine-rich repeat-containing proteins. Proc Natl Acad Sci U S A 109(20):7917-22, 2012. e-Pub 2012. PMID: 22547800.
- Yan J, Aldrich RW. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature 466(7305):513-6, 2010. e-Pub 2010. PMID: 20613726.
- Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS. Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity. Mol Cell Proteomics 7(11):2188-98, 2008. e-Pub 2008. PMID: 18573811.
- Yan J, Dashdorj N, Baniulis D, Yamashita E, Savikhin S, Cramer WA. On the structural role of the aromatic residue environment of the chlorophyll a in the cytochrome b6f complex. Biochemistry 47(12):3654-61, 2008. e-Pub 2008. PMID: 18302324.
- Yan J, Kurisu G, Cramer WA. Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex. Proc Natl Acad Sci U S A 103(1):69-74, 2006. e-Pub 2006. PMID: 16371475.
- Adams KL, Tsoi S, Yan J, Durbin SM, Ramdas AK, Cramer WA, Sturhahn W, Alp EE, Schulz C. Fe vibrational spectroscopy of myoglobin and cytochrome f. J Phys Chem B 110(1):530-6, 2006. e-Pub 2006. PMID: 16471565.
- Kim H, Dashdorj N, Zhang H, Yan J, Cramer WA, Savikhin S. An anomalous distance dependence of intraprotein chlorophyll-carotenoid triplet energy transfer. Biophys J 89(4):L28-30, 2005. e-Pub 2005. PMID: 16055550.
- Dashdorj N, Zhang H, Kim H, Yan J, Cramer WA, Savikhin S. The single chlorophyll a molecule in the cytochrome b6f complex: unusual optical properties protect the complex against singlet oxygen. Biophys J 88(6):4178-87, 2005. e-Pub 2005. PMID: 15778449.
- Yan J, Cramer WA. Molecular control of a bimodal distribution of quinone-analogue inhibitor binding sites in the cytochrome b(6)f complex. J Mol Biol 344(2):481-93, 2004. e-Pub 2004. PMID: 15522300.
- Yan J, Cramer WA. Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein. J Biol Chem 278(23):20925-33, 2003. e-Pub 2003. PMID: 12672829.
- Yan J, Liu Y, Mao D, Li L, Kuang T. The presence of 9-cis-beta-carotene in cytochrome b(6)f complex from spinach. Biochim Biophys Acta-Bioenerg 1506(3):182-8, 2001. e-Pub 2001. PMID: 11779551.
- Li X, Li Z, Yan J, Li H, Han B, Hu K, Wang A. Investigation of structural change of purple membrane in storage by transmission electron microscope and atomic force microscope. Chinese Science Bulletin 46:1753-56, 2001. e-Pub 2001.
- Yan J, Mao D, Chen H, Kuang T, Li B. Effects of membrane lipids on the electron transfer activity of cytochrome b6f complex from spinach. Acta Botanica Sinica 42:1267-70, 2000. e-Pub 2000.
- Sun Q, Li L, Yan J, Kuang T, Li B. Effects of light and temperature on the expression of the Lhcb2 gene in pea. Acta Bontanica Sinica 42:258-62, 2000. e-Pub 2000.
- Mao D, Yan J, Zhai X, Sun Q, l L. A new method for purifying Cyt b6f protein complex. Acta Botanica Sinica 40:1022-27, 1998. e-Pub 1998.
Invited Articles
- Shah KR, Guan X, Yan J. Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling. Cell Calcium 104:102594, 2022. e-Pub 2022. PMID: 35561646.
- Shah KR, Guan X, Yan J. Structural and Functional Coupling of Calcium-Activated BK Channels and Calcium-Permeable Channels Within Nanodomain Signaling Complexes. Front Physiol 12:796540, 2022. e-Pub 2022. PMID: 35095560.
- Li Q, Yan J. Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits. Int Rev Neurobiol 128:51-90, 2016. e-Pub 2016. PMID: 27238261.
- Zhang J, Yan J. Regulation of BK channels by auxiliary γ subunits. Front Physiol 5:401, 2014. e-Pub 2014. PMID: 25360119.
- Cramer WA, Zhang H, Yan J, Kurisu G, Smith JL. Transmembrane traffic in the cytochrome b6f complex. Annu Rev Biochem 75:769-90, 2006. e-Pub 2006. PMID: 16756511.
- Cramer WA, Zhang H, Yan J, Kurisu G. Binding sites of lipophilic quinone and quinone analogue inhibitors in the cytochrome b6f complex of oxygenic photosynthesis. Biochemical Society Transactions 33(Pt 5):921-23, 2005. e-Pub 2005.
- Cramer WA, Yan J, Zhang H, Kurisu G, Smith JL. Structure of the cytochrome b6f complex: new prosthetic groups, Q-space, and the 'hors d'oeuvres hypothesis' for assembly of the complex. Photosynth Res 85(1):133-43, 2005. e-Pub 2005. PMID: 15977064.
- Smith JL, Zhang H, Yan J, Kurisu G, Cramer WA. Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces. Curr Opin Struct Biol 14(4):432-9, 2004. e-Pub 2004. PMID: 15313237.
- Cramer WA, Zhang H, Yan J, Kurisu G, Smith JL. Evolution of photosynthesis: time-independent structure of the cytochrome b6f complex. Biochemistry 43(20):5921-9, 2004. e-Pub 2004. PMID: 15147175.
Book Chapters
- Cramer WA, Savikhin S, Yan J, Yamashita E. Chapter 6: The Enigmatic Chlorophyll a Molecule in the Cytochrome b6f Complex. In: The Chloroplast: Basics and Applications. Springer, 89-93, 2010.
- Cramer WA, Zhang H, Yan J, Kurisu G, Dashdorj N, Kim H, Savikhin S. Chapter 20: Structure-Function of the Cytochrome b6f Complex: A Design that has Worked for Three Billion Years. In: Primary Processes of Photosynthesis: Principles and Apparatus. Royal Society of Chemistry, 417-46, 2008.
Patient Reviews
CV information above last modified July 22, 2026