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Jiyong Liang, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Systems Biology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2004 University of Toronto, Toronto, Ontario, Canada, PHD, Medical Biophysics
1990 Nanjing Medical University, Nanjing, Jiangsu, China, MS, Medical Sciences
1983 Yangzhou Medical School, Yangzhou, Jiangsu, China, MD, Medicine

Experience/Service

Other Appointments/Responsibilities

Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2007-12/2007
Odyssey Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, 4/2004-3/2007
Research Associate, University of Maryland Dentistry School, Baltimore, MD, 3/1997-7/1999
Visiting Scholar, University of Maryland at Baltimore, Baltimore, MD, 3/1996-3/1997
Lecturer, Jiangnan University, Wuxi, Jiangsu, China, 8/1990-3/1996

Selected Publications

Peer-Reviewed Original Research Articles

1. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation. Mol Cell. e-Pub 5/21/2014. PMID: 24857548.
2. Park YY, Kim SB, Han HD, Sohn BH, Kim JH, Liang J, Lu Y, Rodriguez-Aguayo C, Lopez-Berestein G, Mills GB, Sood AK, Lee JS. TARDBP regulates glycolysis in hepatocellular carcinomaby regulating PFKP through miR-520. Hepatology 58(1):182-91, 7/2013. e-Pub 5/2013. PMID: 23389994.
3. Liang J, Mills GB. AMPK: a contextual oncogene or tumor suppressor? Cancer Res 73(10):2929-35, 5/2013. PMID: 23644529.
4. Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Oncogene, 2013. PMID: 23912456.
5. Wang Y, Wang JW, Xiao X, Shan Y, Xue B, Jiang G, He Q, Chen J, Xu HG, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX. Piperlongumine Induces Autophagy by Targeting p38 Signaling. Cell Death Dis 4:e824, 2013. e-Pub 10/2013. PMID: 24091667.
6. Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB, Ding Z. Site specific activation of AKT protects cells from death induced by glucose deprivation. Oncogene, 2013. PMID: 23396361.
7. Xiao X, He Q, Lu C, Werle KD, Zhao RX, Chen J, Davis BC, Cui R, Liang J, Xu ZX. Metformin impairs the growth of Liver Kinase B1-intact cervical cancer cells. Gynecol Oncol 127(1):249-55, 10/2012. PMCID: PMC3432698.
8. Cheong JH, Park ES, Liang J, Dennison JB, Tsavachidou D, Nguyen-Charles C, Cheng KW, Hall H, Zhang D, Lu Y, Ravoori M, Kundra V, Ajani JA, Lee JS, Hong WK, Mills GB. Dual inhibition of Tumor Energy Pathway by 2-deoxy glucose and metformin Is Effective Against a Broad Spectrum of Preclinical Cancer Models. Mol Cancer Ther, 12/2011. PMID: 21992792.
9. Wang S, Wang H, Davis BC, Liang J, Cui R, Chen SJ, Xu ZX. PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1. Biochem Biophys Res Commun 412(2), 8/2011. PMID: 21821012.
10. Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 49(5):429-39, 5/2010. PMID: 20146253.
11. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One 5(3):e9910, 2010. PMCID: PMC2845649.
12. Larrea MD, Liang J, Da Silva T, Hong F, Shao SH, Han K, Dumont D, Slingerland JM. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol 28(20):6462-72, 10/2008. PMCID: PMC2577417.
13. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ 14(11):1948-57, 11/2007. PMID: 17690712.
14. Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9(2):218-24, 2/2007. PMID: 17237771.
15. Ding Z, Liang J, Lu Y, Yu Q, Songyang Z, Lin SY, Mills GB. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A 103(41):15014-9, 10/2006. PMCID: PMC1636760.
16. Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 10(2):145-157, 8/2006. PMID: 16872911.
17. Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng PS, Wu Y, Lee V, Slingerland J, Dumont D, Yang BB. The roles of versican V1 and V2 isoforms in cell proliferation and apoptosis. Mol Biol Cell 16(3):1330-1340, 3/2005. PMID: 15635104.
18. Rao JN, Liang JY, Chakraborti P, Feng P. Effect of thyroid hormone on the development and gene expression of hormone receptors in rat testes in vivo. J Endocrinol Invest 26(5):435-43, 5/2003. PMID: 12906371.
19. Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8(10):1153-60, 10/2002. PMID: 12244302.
20. Feng P, Liang JY, Li TL, Guan ZX, Zou J, Franklin R, Costello LC. Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol 4(1):31-6, 2000. PMID: 10851304.
21. Liang JY, Liu YY, Zou J, Franklin RB, Costello LC, Feng P. Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate 40(3):200-7, 8/1999. PMID: 10398282.
22. Liang JY, Fontana JA, Rao JN, Ordonez JV, Dawson MI, Shroot B, Wilber JF, Feng P. Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3. Prostate 38(3):228-36, 2/1999. PMID: 10068347.

Invited Articles

1. Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2(4):339-45, Jul-Aug, 7/2003. PMID: 12851486.

Grant & Contract Support

Title: Mechanisms underlying delayed recurrence of ER positive breast cancer: a critical step in the development of effective biomarkers and therapies
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Gordon B. Mills
Duration: 5/1/2010 - 4/30/2013

Last updated: 6/4/2014