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Joe Y. Chang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor (tenure), Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Clinical Section Chief, Thoracic Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1997 The University of Texas MD Anderson Cancer Center, Houston, TX, PHD, Cancer Biology
1988 Graduate School, Fudan University, Shanghai, China, MS, Immunology
1985 Shanghai Medical College, Fudan University, Shanghai, China, MD, Medicine

Postgraduate Training

7/1997-7/2002 Clinical Residency, Radiation Oncology, Rush-Presbyterian St. Luke Medical Center, Chicago, IL
7/1990-7/1993 Visiting Scientist, Thoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
7/1988-7/1990 Research Residency, Clinical and Translational Oncology, Shanghai Medical University, Shanghai, China

Board Certifications

1/2002 American Board of Radiology (Radiation Oncology)

Experience/Service

Academic Appointments

Visiting Scientist, Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 7/1990-7/1993

Administrative Appointments/Responsibilities

Director, Stereotactic Body Radiation Therapy Program, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, 2009-present

Honors and Awards

2008 Travel Award, American Radium Society
2007-2010 America's Top Oncologists, Consumers' Research Council of America
2005-2006 America's Top Radiologist, Consumers' Research Council of America
2004-2005 America's Top Physicians Award, Consumers' Research Council of America
2004 Career Developmental Award, University of Texas Lung Cancer Spore, NIH
2004 RSNA Research Scholar Award, RSNA
2000 ASTRO 2000 Annual Meeting Travel Award, ASTRO
2000 First Place Winner of Resident Research Competition, Rush-Presbyterian St. Luke's Medical Center
1995-1997 NIH Research Training Award, NIH
1995 Dr. Alexander Y. Wang Memorial Award, Society of Chinese Bioscientist in America
1995 First Place Winner of John P. McGovern Graduate Student Award, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center
1985 Shanghai Outstanding Medical Graduates (Top 10) Award, Shanghai Municipal Government

Selected Publications

Peer-Reviewed Original Research Articles
1. Koay EJ, Lege D, Mohan R, Komaki R, Cox JD, and Chang JY. Adaptive/non-adaptive proton radiation planning and outcome in a phase II trial for locally advanced non-small cell lung cancer. Int J Rad Onc Bio Phy. In Press.
2. Quan E, Chang J, Liao Z, Xia T, Liu H, Balter P, Zhang X. Automated VMAT Treatment Planning for Stage III Lung Cancer: How Does It Compare with IMRT? International Journal of Radiation Oncology, Biology, Physics. In Press.
3. Komaki R, Wei X, Allen PK, Liao Z, Milas L, Cox JD, O'Reilly M, Chang JY, McAleer MF, Jeter M, Blumenschein GR, Kies MS. Phase I study of celecoxib with concurrent irinotecan, cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer. Frontiers in Thoracic Oncology. In Press.
4. Zhang X, Liu H, Balter P, Allen PK, Komaki R, Pan T, Chuang HH, Chang JY. Positron Emission Tomography for Assessing Local Failure after Stereotactic Body Radiotherapy for Non-small Cell Lung Cancer. Int J Rad Onc Bio Phy. In Press.
5. Liu H, Zhang X, Vinogradskiy YY, Swisher SG , Komaki R, Chang JY. Predicting radiation pneumonitis after stereotactic ablative radiotherapy in patients previously treated with conventional thoracic radiotherapy. Int J Rad Onc Bio Phy. In Press.
6. Shirvani SM and Chang JY. Scalpel or SABR for Treatment of Early-Stage Lung Cancer: Clinical Considerations for the Multidisciplinary Team. Cancers. In Press.
7. Xiang ZL, Zeng ZC, Fan J, Tang ZY, He J, Zeng HY, Chang JY. The expression of HIF-1a in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome. Mol Biol Rep 39(2):2021-2029, 2/2012. e-Pub 6/2011. PMID: 21647551.
8. Shirvani SM, Komaki R, Heymach JV, Fossella FV, Chang JY. Positron Emission Tomography/Computed Tomography-Guided Intensity-Modulated Radiotherapy for Limited-Stage Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys 82(1):e91-7, 1/2012. e-Pub 4/2011. PMID: 21489716.
9. Grosshans DR, Boehling, NS, Palmer M, Spicer C, Erice R, Cox JD, Komaki R and Chang JY. Alternative Beam Arrangements for IMRT Planning in Patients with Carcinoma of the Distal Esophagus. Practical Radiation Oncology 2:41-45, 2012.
10. Yu W, Fu XL, Zhang YJ, Xiang JQ, Shen L, Chang JY. A Prospective Evaluation of Staging and Target Volume Definition of Lymph Nodes by (18)FDG PET/CT in Patients with Squamous Cell Carcinoma of Thoracic Esophagus. Int J Radiat Oncol Biol Phys 81(5):e759-765, 12/2011. e-Pub 4/2011. PMID: 21470788.
11. Decker RH, Langer CJ, Rosenzweig KE, Chang JY, Gewanter RM, Ginsburg ME, Kong FM, Lally BE, Videtic GM, Movsas B. ACR Appropriateness Criteria® postoperative adjuvant therapy in non-small cell lung cancer. Am J Clin Oncol 34(5):537-44, 10/2011. PMID: 21946673.
12. Welsh J, Thomas J, Shah D, Allen PK, Wei X, Mitchell K, Gao S, Balter P, Komaki R, Chang JY. Obesity increases the risk of chest wall pain from thoracic stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 81(1):91-6, 9/2011. e-Pub 6/2010. PMID: 20542388.
13. Chang JY, Komaki R, Wen HY, De Gracia B, Bluett JB, McAleer MF, Swisher SG, Gillin M, Mohan R, Cox JD. Toxicity and Patterns of Failure of Adaptive/Ablative Proton Therapy for Early-Stage, Medically Inoperable Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 80(5):1350-7, 8/2011. e-Pub 1/2011. PMCID: PMC3117089.
14. Sejpal S, Komaki R, Tsao A, Chang JY, Liao Z, Wei X, Allen PK, Lu C, Gillin M, Cox JD. Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer. Cancer 117(13):3004-3013, 7/2011. e-Pub 1/2011. PMID: 21264827.
15. Peng Y, Vedam S, Chang JY, Gao S, Sadagopan R, Bues M, Balter P. Implementation of Feedback-Guided Voluntary Breath-Hold Gating for Cone Beam CT-Based Stereotactic Body Radiotherapy. Int J Radiat Oncol Biol Phys 80(3):909-917, 7/2011. e-Pub 4/2011. PMID: 21470784.
16. Register SP, Zhang X, Mohan R, Chang JY. Proton Stereotactic Body Radiation Therapy for Clinically Challenging Cases of Centrally and Superiorly Located Stage I Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys 80(4):1015-22, 7/2011. e-Pub 7/2010. PMCID: PMC2952351.
17. Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P. Genome-Wide Association Study of Survival in Non-Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy. J Natl Cancer Inst 103(10):817-825, 5/2011. e-Pub 4/2011. PMCID: PMC3096796.
18. Nguyen GH, Murph MM, Chang JY. Cancer Stem Cell Radioresistance and Enrichment: Where Frontline Radiation Therapy May Fail in Lung and Esophageal Cancers. Cancers (Basel) 3(1):1232-1252, 3/2011. PMCID: PMC3095975.
19. Chang JY, Komaki R, Lu C, Wen HY, Allen PK, Tsao A, Gillin M, Mohan R, Cox JD. Phase 2 study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III nonsmall cell lung cancer. Cancer. e-Pub 3/2011. PMCID: PMC3174272.
20. Ikushima H, Balter P, Komaki R, Hunjun S, Bucci MK, Liao Z, McAleer MF, Yu ZH, Zhang Y, Chang JY, Dong L. Daily Alignment Results of In-Room Computed Tomography-Guided Stereotactic Body Radiation Therapy for Lung Cancer. Int J Radiat Oncol Biol Phys 79(2):473-480, 2/2011. e-Pub 4/2010. PMID: 20399032.
21. Gomez DR, Chang JY. Adaptive Radiation for Lung Cancer. J Oncol 2011, 2011. e-Pub 8/2010. PMCID: PMC2931378.
22. Kelly P, Balter PA, Rebueno N, Sharp HJ, Liao Z, Komaki R, Chang JY. Stereotactic body radiation therapy for patients with lung cancer previously treated with thoracic radiation. Int J Radiat Oncol Biol Phys 78(5):1387-1393, 12/2010. e-Pub 4/2010. PMID: 20381271.
23. Gopal RS, Dubey S, Rosenzweig KE, Chang JY, Decker R, Gewanter RM, Kong FM, Lally BE, Langer CJ, Lee HK, Movsas B. ACR Appropriateness Criteria® on Induction and Adjuvant Therapy for Stage N2 Non-Small-Cell Lung Cancer: expert panel on radiation oncology-lung. Int J Radiat Oncol Biol Phys 78(4):969-74, 11/2010. e-Pub 8/2010. PMID: 20813465.
24. Kim MP, Correa AM, Lee J, Rice DC, Roth JA, Mehran RJ, Walsh GL, Ajani JA, Maru DM, Chang JY, Marom EM, Macapinlac HA, Lee JH, Vaporciyan AA, Rice T, Swisher SG, Hofstetter WL. Pathologic T0N1 Esophageal Cancer After Neoadjuvant Therapy and Surgery: An Orphan Status. Ann Thorac Surg 90(3):884-890, 9/2010. e-Pub 2010. PMID: 20732513.
25. Chang JY, Cox JD. Improving radiation conformality in the treatment of non-small cell lung cancer. Semin Radiat Oncol 20(3):171-7, 7/2010. PMCID: PMC2905742.
26. Zhang X, Li Y, Pan X, Xiaoqiang L, Mohan R, Komaki R, Cox JD, Chang JY. Intensity-modulated proton therapy reduces normal tissue doses compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB-non-small cell lung cancer: a virtual clinical study. Int J Radiat Oncol Biol Phys 77(2):357-366, 6/2010. e-Pub 8/2009. PMCID: PMC2868090.
27. Gewanter RM, Rosenzweig KE, Chang JY, Decker R, Dubey S, Kong FM, Lally BE, Langer CJ, Lee HK, Movsas B. ACR Appropriateness Criteria: nonsurgical treatment for non-small-cell lung cancer: good performance status/definitive intent. Curr Probl Cancer 34(3):228-249, May-Jun, 5/2010. PMID: 20541060.
28. Nelson C, Balter P, Morice RC, Bucci K, Dong L, Tucker S, Vedam S, Chang JY, Starkschall G. Evaluation of Tumor Position and PTV Margins Using Image Guidance and Respiratory Gating. Int J Radiat Oncol Biol Phys 76(5):1578-1585, 4/2010. e-Pub 2/2010. PMID: 20137865.
29. Hildebrandt MA, Komaki R, Liao Z, Gu J, Chang JY, Ye Y, Lu C, Stewart DJ, Minna JD, Roth JA, Lippman SM, Cox JD, Hong WK, Spitz MR, Wu X. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. PLoS One 5(8):pii: e12402, 2010. e-Pub 8/2010. PMCID: PMC2928273.
30. Yu W, Fu XL, Zhang YJ, Xiang JQ, Shen L, Jiang GL, Chang JY. GTV spatial conformity between different delineation methods by (18)FDG PET/CT and pathology in esophageal cancer. Radiother Oncol 93(3):441-446, 12/2009. e-Pub 8/12/2009. PMID: 19682760.
31. McGovern SL, Liao Z, Bucci MK, McAleer MF, Jeter MD, Chang JY, O'Reilly MS, Cox JD, Allen PK, Komaki R. Is sex associated with the outcome of patients treated with radiation for nonsmall cell lung cancer? Cancer 115(14):3233-3242, 7/2009. PMID: 19472405.
32. Zhang Z, Chen Y, Chen Y, Jeter M, Hofstetter WL, Ajani J, Swisher SG, Chang JY, Allen PK, Cox JD, Komaki R, Liao ZX. Outcomes with Esophageal Cancer Radiation Therapy. J Thorac Oncol 4(7):880-888, 7/2009. e-Pub 5/2009. PMID: 19458557.
33. Gayed IW, Liu HH, Wei X, Liao Z, Yusuf SW, Chang JY, Bassett R, Komaki R. Patterns of cardiac perfusion abnormalities after chemoradiotherapy in patients with lung cancer. J Thorac Oncol 4(2):179-184, 2/2009. PMCID: PMC19179893.
34. Ezhil M, Vedam S, Balter P, Choi B, Mirkovic D, Starkschall G, Chang JY. Determination of patient-specific internal gross tumor volumes for lung cancer using four-dimensional computed tomography. Radiat Oncol 4:4, 1/2009. PMCID: PMC2645420.
35. Sulman EP, Komaki R, Klopp AH, Cox JD, Chang JY. Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer. Radiat Oncol 4(1):5, 1/2009. PMCID: PMC2651897.
36. Riegel AC, Chang JY, Vedam SS, Johnson V, Chi PC, Pan T. Cine Computed Tomography Without Respiratory Surrogate in Planning Stereotactic Radiotherapy for Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys 73(2):433-441, 2009. e-Pub 7/2008. PMID: 18644683.
37. Vassiliev ON, Kry SF, Chang JY, Balter PA, Titt U, Mohan R. Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac. J Appl Clin Med Phys 10(1):2880, 2009. e-Pub 1/2009. PMID: 19223837.
38. Wu X, Lu C, Ye Y, Chang J, Yang H, Lin J, Gu J, Hong WK, Stewart D, Spitz MR. Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy. Pharmacogenet Genomics 18(11):955-965, 11/2008. PMCID: PMC2665725.
39. Chang JY, Balter PA, Dong L, Yang Q, Liao Z, Jeter M, Bucci MK, McAleer MF, Mehran RJ, Roth JA, Komaki R. Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 72(4):967-71, 11/2008. PMCID: PMC18954709.
40. Gayed IW, Chang J, Kim EE, Nuñez R, Chasen B, Liu HH, Kobayashi K, Zhang Y, Liao Z, Gohar S, Jeter M, Henderson L, Erwin W, Komaki R. Lung perfusion imaging can risk stratify lung cancer patients for the development of pulmonary complications after chemoradiation. J Thorac Oncol 3(8):858-64, 8/2008. PMID: 18670303.
41. Wagener M, Zhang X, Villarreal HG, Levy L, Allen P, Shentu S, Fang B, Krishnan S, Chang JY, Cheung MR. Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer. Oncol Rep 19(5):1071-7, 5/2008. PMCID: PMC18425360.
42. Zhang X, Komaki R, Wang L, Fang B, Chang JY. Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus. Clin Cancer Res 14(9):2813-23, 5/2008. PMCID: PMC18452149.
43. Kennedy MP, Jimenez CA, Chang J, Fossella F, Eapen GA, Morice RC. Optimisation of bronchial brachytherapy catheter placement with a modified airway stent. Eur Respir J 31(4):902-3, 4/2008. PMCID: PMC18378785.
44. Qiao XY, Wang W, Zhou ZG, Gao XS, Chang JY. Comparison of efficacy of regional and extensive clinical target volumes in postoperative radiotherapy for esophageal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 70(2):396-402, 2/2008. e-Pub 9/2007. PMID: 17855004.
45. Chang JY, Dong L, Liu H, Starkschall G, Balter P, Mohan R, Liao Z, Cox JD, Komaki R. Image-guided radiation therapy for non-small cell lung cancer. J Thorac Oncol 3(2):177-86, 2/2008. PMCID: PMC18303441.
46. Nelson C, Balter P, Chang JY, et al.. A Technique for Reducing Patient Setup Uncertainties by Aligning and Verifying Daily Positioning of a Moving Tumor using Implanted Fiducials. J Appl Clin Med Phys 9(4):2766, 2008. PMCID: PMC19020478.
47. Britton KR, Starkschall G, Liu H, Chang JY, Bilton S, Ezhil M, John-Baptiste S, Kantor M, Cox JD, Komaki R, Mohan R.. Consequences of anatomic changes and respiratory motion on radiation dose distributions in conformal radiotherapy for locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 73(1):94-102, 2008. e-Pub 10/2008. PMCID: PMC18929448.
48. Hui Z, Zhang X, Starkschall G, Li Y, Mohan R, Komaki R, Cox JD, Chang JY. Effects of interfractional motion and anatomic changes on proton therapy dose distribution in lung cancer. Int J Radiat Oncol Biol Phys 72(5):1385-1395, 2008. e-Pub 5/2008. PMCID: PMC18486357.
49. Klopp AH, Chang JY, Tucker SL, Sulman EP, Balter PA, Liu HH, Bucci MK, Macapinlac HA, Komaki R, Cox JD. Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation. Int J Radiat Oncol Biol Phys 69(5):1409-16, 12/2007. e-Pub 9/2007. PMID: 17904303.
50. Rice DC, Smythe WR, Liao Z, Guerrero T, Chang JY, McAleer MF, Jeter MD, Correa A, Vaporciyan AA, Liu HH, Komaki R, Forster KM, Stevens CW. Dose-dependent pulmonary toxicity after postoperative intensity-modulated radiotherapy for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys 69(2):350-7, 10/2007. e-Pub 4/2007. PMID: 17467922.
51. Zhu G, Cao X, Chang JY, Milas L, Wallace S, Li C. Polymeric retinoid prodrug PG-4HPR enhances the radiation response of lung cancer. Oncol Rep 18(3)(3):645-651, 9/2007. PMID: 17671714.
52. Shioyama Y, Jang SY, Liu HH, Guerrero T, Wang X, Gayed IW, Erwin WD, Liao Z, Chang JY, Jeter M, Yaremko BP, Borghero YO, Cox JD, Komaki R, Mohan R. Preserving functional lung using perfusion imaging and intensity-modulated radiation therapy for advanced-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 68(5):1349-1358(5):1349-58, 8/2007. e-Pub 4/2007. PMID: 17446001.
53. Britton KR, Starkschall G, Tucker SL, Pan T, Nelson C, Chang JY, Cox JD, Mohan R, Komaki R. Assessment of gross tumor volume regression and motion changes during radiotherapy for non-small-cell lung cancer as measured by four-dimensional computed tomography. Int J Radiat Oncol Biol Phys 68(4):1036-1046, 7/2007. e-Pub 3/2007. PMID: 17379442.
54. Huang EH, Liao Z, Cox JD, Guerrero TM, Chang JY, Jeter M, Borghero Y, Wei X, Fossella F, Herbst RS, Blumenschein GR, Moran C, Allen PK, Komaki R. Comparison of outcomes for patients with unresectable, locally advanced non-small-cell lung cancer treated with induction chemotherapy followed by concurrent chemoradiation vs. concurrent chemoradiation alone. Int J Radiat Oncol Biol Phys 68(3):779-85, 7/2007. e-Pub 4/2007. PMID: 17418967.
55. Liu HH, Balter P, Tutt T, Choi B, Zhang J, Wang C, Chi M, Luo D, Pan T, Hunjan S, Starkschall G, Rosen I, Prado K, Liao Z, Chang J, Komaki R, Cox JD, Mohan R, Dong L. Assessing respiration-induced tumor motion and internal target volume using four-dimensional computed tomography for radiotherapy of lung cancer. Int J Radiat Oncol Biol Phys 68(2):531-40, 6/2007. e-Pub 3/2007. PMID: 17398035.
56. Kang Y, Zhang X, Chang JY, Wang H, Wei X, Liao Z, Komaki R, Cox JD, Balter PA, Liu H, Zhu XR, Mohan R, Dong L. 4D Proton treatment planning strategy for mobile lung tumors. Int J Radiat Oncol Biol Phys 67:906-14, 2007. PMCID: PMC17293240.
57. Nelson C, Starkschall G, Balter P, Morice RC, Stevens CW, Chang JY. Assessment of lung tumor motion and setup uncertainties using implanted fiducials. Int J Radiat Oncol Biol Phys 67:915-23, 2007. PMCID: PMC17293241.
58. Gao XS, Qiao X, Wu F, Cao L, Meng X, Dong Z, Wang X, Gao G, Wu TT, Komaki R, Chang JY. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma. Int J Radiat Oncol Biol Phys 67:389-96, 2007. PMCID: PMC17236963.
59. Takahashi N, Yang DJ, Kohanim S, Oh CS, Yu DF, Azhdarinia A, Kurihara H, Zhang X, Chang JY, Kim EE. Targeted functional imaging of estrogen receptors with (99m)Tc-GAP-EDL. Eur J Nucl Med Mol Imaging 34:354-362, 2007. PMCID: PMC17021817.
60. Chang JY, Moughan J, Johnstone DW, Komaki R, Goldberg M, Langer CJ, Beadle BM, Owen J, Movsas B. Surgical patterns of care in operable lung carcinoma treated with radiation. J Thorac Oncol 6(6):526-531, 7/2006. PMID: 17409912.
61. Wang S, Liao Z, Chen Y, Chang JY, Jeter M, Guerrero T, Ajani J, Phan A, Swisher S, Allen P, Cox JD, Komaki R. Esophageal cancer located at the neck and upper thorax treated with concurrent chemoradiation: a single-institution experience. J Thorac Oncol 1(3):252-9, 3/2006. PMID: 17409865.
62. Lu C, Spitz MR, Zhao H, Dong Q, Truong M, Chang JY, Blumenschein GR, Jr, Hong WK, Wu X. Association between glutathione S-transferase pi polymorphisms and survival in patients with advanced nonsmall cell lung carcinoma. Cancer 106:441-7, 2006. PMCID: PMC16342067.
63. Wang XS, Fairclough DL, Liao Z, Komaki R, Chang JY, Mobley GM, Cleeland CS. Longitudinal study of the relationship between chemoradiation therapy for non-small-cell lung cancer and patient symptoms. J Clin Oncol 24:4485-91, 2006. PMCID: PMC16983118.
64. Xia T, Li H, Sun Q, Wang Y, Fan N, Yu Y, Li P, Chang JY. Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 66:117-25, 2006. PMCID: PMC16765528.
65. Nelson C, Starkschall G, Chang JY. The potential for dose escalation in lung cancer as a result of systematically reducing margins used to generate planning target volume. Int J Radiat Oncol Biol Phys 65:573-86, 2006. PMCID: PMC16690439.
66. Gayed IW, Liu HH, Yusuf SW, Komaki R, Wei X, Wang X, Chang JY, Swafford J, Broemeling L, Liao Z. The prevalence of myocardial ischemia after concurrent chemoradiation therapy as detected by gated myocardial perfusion imaging in patients with esophageal cancer. J Nucl Med 47:1756-62, 2006. PMCID: PMC17079807.
67. Chang JY, Zhang X, Komaki R, Cheung R, Fang B. Tumor-specific apoptotic gene targeting overcomes radiation resistance in esophageal adenocarcinoma. Int J Radiat Oncol Biol Phys 64:1482-94, 2006. PMCID: PMC16580499.
68. Liao Z, Komaki R, Milas L, Yuan C, Kies M, Chang JY, Jeter M, Guerrero T, Blumenschien G, Smith CM, Fossella F, Brown B, Cox JD. A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer. Clin Cancer Res 11:3342-8, 2005. PMCID: PMC15867233.
69. Zhang Z, Liao Z, Jin J, Ajani J, Chang JY, Jeter M, Guerrero T, Stevens CW, Swisher S, Ho L, Yao J, Allen P, Cox JD, Komaki R. Dose-response relationship in locoregional control for patients with stage II-III esophageal cancer treated with concurrent chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 61:656-64, 2005. PMCID: PMC15708243.
70. Chandra A, Guerrero TM, Liu HH, Tucker SL, Liao Z, Wang X, Murshed H, Bonnen MD, Garg AK, Stevens CW, Chang JY, Jeter MD, Mohan R, Cox JD, Komaki R. Feasibility of using intensity-modulated radiotherapy to improve lung sparing in treatment planning for distal esophageal cancer. Radiother Oncol 77:247-53, 2005. PMCID: PMC16298001.
71. Chang JY, Komaki R, Sasaki R, Liao Z, Stevens CW, Lu C, Fossella FV, Allen PK, Cox JD, Spitz MR, Wu X. High mutagen sensitivity in peripheral blood lymphocytes predicts poor overall and disease-specific survival in patients with stage III non-small cell lung cancer treated with radiotherapy and chemotherapy. Clin Cancer Res 11:2894-8, 2005. PMCID: PMC15837739.
72. Komaki R, Chang JY, Wu X, Allen PK, Milas L, Liao Z, Fossella FV, Travis E, Spitz MR. Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy. Semin Oncol 32:S92-8, 2005. PMCID: PMC16015542.
73. Zhang X, Cheung RM, Komaki R, Fang B, Chang JY. Radiotherapy sensitization by tumor-specific TRAIL gene targeting improves survival of mice bearing human non-small cell lung cancer. Clin Cancer Res 11:6657-68, 2005. PMCID: PMC16166445.
74. Wang H, Dong L, O'Daniel J, Mohan R, Garden AS, Ang KK, Kuban DA, Bonnen M, Chang JY, Cheung R. Validation of an accelerated 'demons' algorithm for deformable image registration in radiation therapy. Phys Med Biol 50:2887-905, 2005. PMCID: PMC15930609.
75. Yang DJ, Bryant J, Chang JY, Mendez R, Oh CS, Yu DF, Ito M, Azhdarinia A, Kohanim S, Edmund Kim E, Lin E, Podoloff DA. Assessment of cyclooxygense-2 expression with 99mTc-labeled celebrex. Anticancer Drugs 15:255-63, 2004. PMCID: PMC15014359.
76. Murshed H, Liu HH, Liao Z, Barker JL, Wang X, Tucker SL, Chandra A, Guerrero T, Stevens C, Chang JY, Jeter M, Cox JD, Komaki R, Mohan R. Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 58:1258-67, 2004. PMCID: PMC15001271.
77. Taylor NA, Liao ZX, Cox JD, Stevens C, Roth J, Walsh G, Chang JY, Guerrero T, Jeter M, Putnam J, Jr, Fossella FV, Allen P, Komaki R. Equivalent outcome of patients with clinical Stage IIIA non-small-cell lung cancer treated with concurrent chemoradiation compared with induction chemotherapy followed by surgical resection. Int J Radiat Oncol Biol Phys 58:204-12, 2004. PMCID: PMC14697440.
78. Jin J, Liao Z, Zhang Z, Ajani J, Swisher S, Chang JY, Jeter M, Guerrero T, Stevens CW, Vaporciyan A, Putnam J, Jr, Walsh G, Smythe R, Roth J, Yao J, Allen P, Cox JD, Komaki R. Induction chemotherapy improved outcomes of patients with resectable esophageal cancer who received chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys 60:427-36, 2004. PMCID: PMC15380576.
79. Ahamad A, Stevens CW, Smythe WR, Liao Z, Vaporciyan AA, Rice D, Walsh G, Guerrero T, Chang J, Bell B, Komaki R, Forster KM. Promising early local control of malignant pleural mesothelioma following post-operative intensity modulated radiotherapy (IMRT) to the chest. Cancer J 9(6):476-484, Nov-Dec, 11/2003. PMID: 14740977.

Invited Articles
1. Shirvani SM, Chang JY. Proton therapy for non–small cell lung cancer: current evidence and future directions. Thoracic Cancer. In Press.
2. Liu H, Chang JY. Proton therapy in clinical practice. Chin J Cancer 30(5):315-326, 5/2011. PMID: 21527064.
3. Lin SH, Chang JY. Esophageal cancer: diagnosis and management. Chin J Cancer 29(10):843-854, 10/2010. e-Pub 2010. PMID: 20868553.
4. Chang JY, Roth JA. Stereotactic body radiation therapy for stage I NSCLC. Thoracic Surgery Clinics 17:251-259, 1/2007.
5. Chang JY, Liu HH, Komaki R. Intensity modulated radiation therapy and proton radiotherapy for non-small cell lung cancer. Curr Oncol Rep 7:255-9, 7/2005. PMID: 15946583.

Editorials
1. Chang JY, Zhang X. In Reply to Dr. Bonger et al. Int J Radiat Oncol Biol Phys 82(1):492, 1/2012. PMID: 22182717.
2. Chang JY. Stereotactic ablative radiotherapy for stage I NSCLC: Successes and existing challenges. J Thorac Dis 3(3):144-6, 9/2011. PMCID: PMC3256526.
3. Loo BW, Chang JY, Dawson L, Kavanagh BD, Koong A, Senan S, Timmerman R. Stereotactic ablative radiotherapy: What's in a name? Practical Radiation Oncology 1:38-39, 2011.
4. Chang JY. Telomerase: a potential molecular marker and therapeutic target for cancer. J Surg Oncol 87:1, 2004. PMID: 15112252.

Book Chapters
1. Chang JY, Shirvani SM, Loo BW, Lamond JP, Slotman B, Nagata Y. Stereotactic Ablative Radiation Therapy for Treatment of Intrathoracic Tumors. In: Stereotactic Radiotherapy. Springer. In Press.
2. Chang JY. Cancer of the lung. In: Technical basis of radiation therapy: Practical clinical applications, Fifth edition. Ed(s) Levitt SH, Purdy JA, Perez CA, Poortmans P. Springer, 755-775, 2012.
3. Christodouleas JP and Chang JY. Early stage non-small cell lung cancer. In: Radiation Oncology: a question-based review. Ed(s) Hristov B, Lin SH and Christodouleas JP. Lippincott Williams and Wilkins: Phyladelphia, 199-209, 2011.
4. Shirvani SM and Chang JY. Hypofractionated proton therapy in the treatment of non-small cell lung cancer. In: Hypofractionation: scientific concepts and clinical experiences. Ed(s) Pollack A and Ahmed MM. LumiText Publishing, 339-353, 2011.
5. Lin SH and Chang JY. Lung cancer. In: Decision making in Radiation Oncology. Ed(s) Liu JJ and Bradly LW. Springer: New York, 261-328, 2011.
6. Chang JY. Thorax. In: Uncertainties in external beam radiation therapy. Ed(s) Palta JR and Mackie TR. Medical Physics Publishing, 575-592, 2011.
7. Chang JY and Komaki R. Proton therapy in lung and thoracic cancers. In: Radiation Medicine Rounds: Proton Therapy. Ed(s) Metz J and Thomas C, Jr. Demos Medical Publishing: New York, 523-537, 2010.
8. Chang JY, Komaki R, Roth JA, Herbst r, Cox JD. Image guidance of combined modality management of NSCLC. In: Image-guided radiation therapy for lung cancer. Informa, 1-18, 2008.
9. Chang JY, Mohan R, Cox JD. Image-guided proton radiotherapy. In: Image-guided radiation therapy for lung cancer. Informa, 127-139, 2008.
10. Chang JY. Image-guided radiotherapy guidelines and techniques for NSCLC. In: Image-guided radiation therapy for lung cancer. Informa, 19-38, 2008.
11. Chang JY, Bradley J, Govindan R, Komaki R. Lung. In: Principles and Practice of Radiation Oncology, 5th. Ed(s) Halperin EC, Perez CA and Brady LW. 5th Edition. Lippincott Williams &Wilkin, 1076-1108, 2008.
12. Chang JY, Smith A, Cox JD. Proton therapy. In: Lung Cancer, 3. Ed(s) Roth JA, Cox JD, Hong WK. Blackwell Publishing Ltd, 271-282, 2008.
13. Chang JY, Balter P, Komaki R. Stereotactic body radiation therapy (SBRT) in stage I, selective stage II and isolated peripheral recurrent NSCLC. In: Image-guided radiation therapy for lung cancer. Informa, 93-102, 2008.
14. Onn A, Vaprociyan A, Chang JY, Komaki R, Roth JA, Herbst RS. Cancer of the lung. In: Cancer Medicine, 27. Ed(s) Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holand JF and Frei E. BC Decker Inc, 1179-1225, 2006.
15. Janjan NA, Strom E, Perkins G, Ha, C, Chang JY. Effects of Radiation on the Heart. In: Cancer and the Heart. BC Decker Inc, 75-113, 2006.
16. Komaki R, Chang JY, Liao Z, Cox JD, Mason KA, Milas L. Radioprotectors and chemoprotectors in the management of lung cancer. In: Medical Radiology-Radiation Oncology: Advances in radiation Oncology in lung cancer. 2.2.6. Springer-Verlag, 123-134, 2004.
17. Chang JY, Mukhopadhyay T, Georges RN, Roth JA. Molecular targeting of cancer: retroviral vector-mediated antisense nucleic acid therapy. In: Gene Therapy From Laboratory to the Clinic. 5. World Scientific Publishing Co: New Jersey, 70-106, 1994.
18. Chang JY. Immunotherapy of human hepatocellular carcinoma with lymphokine-activated killer cells and interleukin-2. In: The Advance in Primary Liver Cancer Research, 26. Shanghai Medical University Press, 263-272, 1990.

Last updated: 3/16/2012