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John D. Hazle, PHD, FAAPM, FACR

Present Title & Affiliation

Primary Appointment

Chairman, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Professor, Department of Radiology, University of Texas Medical School, Houston, TX
Faculty, Keck Center for Computational and Structural Biology, Rice University, Houston, TX

Bio Statement

Dr. John D. Hazle is a medical physicist with over 25 years of academic experience.  He is board-certified and licensed in Texas for both therapeutic and diagnostic medical physics.  His primary research interests are image-guided therapy, pre-clinical imaging and novel early detection technologies.  Dr. Hazle shares leadership of the Image Guided Therapy Lab with Dr. Jason Stafford where their work primarily focuses on developing novel approaches to image temperature using MRI. Dr. Hazle has been the Director of the NCI funded Small Animal Cancer Imaging Research Facility for 15 years and was the Director of the NCI funded Experimental Cancer Imaging Research Program from 2008-2012.  He has won numerous awards, most recently M.D. Anderson's President's Recognition for Faculty Excellence Award in 2014.  Dr. Hazle serves on multiple institutional committees, engages as an medical imaging expert with industry partners, and is currently a journal reviewer for six peer reviewed scientific journals.  He is a past President of the American Association of Physicists in Medicine and the Commission for Accreditation of Medical Physics Education Programs.  Dr. Hazle is considered an renowned expert in biomedical imaging and MRI physics.  He is frequently an invited presenter at national and international conferences. Dr. Hazle also holds the Bernard W. Biedenharn Chair in Cancer Research and has a faculty appointment with The University of Texas Graduate School of Biomedical Sciences.

Research Interests

Image guided therapy, MR temperature imaging, pre-clinical imaging, novel early detection technologies.

Clinical Interests

MR imaging, MR guided interventions and surgery and MR guided radiation therapy.

Office Address

The University of Texas MD Anderson Cancer Center
Department of Imaging Physics - Unit 1472
1400 Pressler St.
Houston, TX 77030-4009
Room Number: FCT14.6044
Phone: (713) 792-0612
Fax: (713) 745-0581

Education & Training

Degree-Granting Education

1989 The University of Texas Graduate School of Biomedical Sciences, Houston, TX, PHD, Biophysics
1983 University of Kentucky, Lexington, Lexington, KY, MS, Medical Physics
1981 University of Kentucky, Lexington, KY, BS, Physics

Board Certifications

1998 American Board of Medical Physics (MRI Physics)
1996 American Board of Radiology (Diagnostic Radiologic Physics)
1992 American Board of Radiology (Therapeutic Radiological Physics)


Endowed Positions

Bernard W. Biedenharn Chair in Cancer Research, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 12/2009-present

Honors and Awards

2015 2015 Provost's Distinguished Clinical Faculty Mentor Award, The University of Texas M.D. Anderson Cancer Center

Selected Publications

Peer-Reviewed Original Research Articles

1. Lin JS, Hwang KP, Jackson EF, Hazle JD, Jason Stafford R, Taylor BA. Multiparametric fat-water separation method for fast chemical-shift imaging guidance of thermal therapies. Med Phys 40(10):103302, 10/2013. PMCID: PMC3785573.
2. Rylander MN, Stafford RJ, Hazle J, Whitney J, Diller KR. Heat shock protein expression and temperature distribution in prostate tumours treated with laser irradiation and nanoshells. Int J Hyperthermia 27(8):791-801, 12/2011. PMID: 22098363.
3. Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin M, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J. HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance. Mol Cancer Res 9(3):259-70, 3/2011. e-Pub 3/2011. PMCID: PMC3077053.
4. Black PC, Shetty A, Brown GA, Esparza-Cross E, Metwalli AR, Agarwal PK, McConkey DJ, Hazle JD, Dinney CP. Validating bladder cancer xenograft bioluminescence with magnetic resonance imaging: the significance of hypoxia and necrosis. British J Urol 106(11):1799-804, 12/2010. PMID: 20500508.
5. Fuentes D, Oden JT, Diller KR, Hazle JD, Elliott A, Shetty A, Stafford RJ. Computational modeling and real-time control of patient-specific laser treatment of cancer. Ann Biomed Eng 37(4):763-82, 4/2009. e-Pub 1/2009. PMCID: PMC4064943.
6. Taylor BA, Hwang KP, Elliott AM, Shetty A, Hazle JD, Stafford RJ. Dynamic chemical shift imaging for image-guided thermal therapy: analysis of feasibility and potential. Med Phys 35(2):793-803, 2008. PMID: 18383702.
7. Diagaradjane P, Shetty A, Wang JC, Elliott AM, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford RJ, Cho SH, Tunnell JW, Hazle JD, Krishnan S. Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Letters 8(5):1492-500, 2008. PMCID: PMC3952070.
8. Oden JT, Diller KR, Bajaj C, Browne JC, Hazle JD, Babuska I, Bass J, Demkowicz L, Feng Y, Fuentes D, Prudhomme S, Rylander MN, Stafford RJ, Zhang Y. Development of a computational paradigm for laser treatment of cancer. Lecture Notes in Computer Science 3993:530-537, 2006. PMID: 19421426.
9. Ma J, Vu AT, Son JB, Choi H, Hazle JD. Fat-suppressed three-dimensional dual echo Dixon technique for contrast agent enhanced MRI. J Magn Reson Imaging 23/1:36-41, 2006. PMID: 16315212.
10. Rylander MN, Stafford RJ, Feng Y, Hazle JD, Diller K. Optimizing heat shock protein expression induced by prostate cancer laser therapy through predictive computational models. J Biomed Opt 11/4:041113, 2006. PMID: 16965141.
11. Hazle JD, Diederich CJ, Kangasniemi M, Price RE, Olsson LE, Stafford RJ. MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator. J Magn Reson Imaging 15/4:409-17, 2002. PMID: 11948830.
12. Righetti R, Kallel F, Stafford RJ, Price RE, Krouskop TA, Hazle JD, Ophir J. Elastographic characterization of HIFU-induced lesions in canine livers. Ultrasound Med Biol 25/7:1099-113, 1999. PMID: 10574342.
13. Hazle JD, Jackson EF, Schomer DF, Leeds NE. Dynamic imaging of intracranial lesions using fast spin-echo imaging: differentiation of brain tumors and treatment effects. J Magn Reson Imaging 7/6:1084-93, 1997. PMID: 9400853.
14. McClain KJ, Zhu Y, Hazle JD. Selection of MR images for automated segmentation. J Magn Reson Imaging 5/5:485-92, 1995. PMID: 8574030.
15. Hazle JD, Narayana PA, Kudrle WA. In Vivo Proton NMR Studies of Normal Rat Liver. J Magn Reson 83:595-601, 1989.

Last updated: 9/1/2015