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John D. Hazle, PHD, FAAPM, FACR

Present Title & Affiliation

Primary Appointment

Chairman, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Bernard W. Biedenharn Chair in Cancer Research, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Professor, Department of Radiology, University of Texas Medical School, Houston, TX
Faculty, Keck Center for Computational and Structural Biology, Rice University, Houston, TX

Research Interests

The focus of my research is two-fold: image guided therapy and small animal imaging.  For image guided therapy, I share the MR Guided Therapy (MRGT) lab with Dr. Jason Stafford.  The thrust of the lab has been the development of MR acquisition and processing algorithms for imaging temperature in vivo in real-time - MR temperature imaging (MRTI).  We have applied MRTI techniques to a monitor tumor ablation from a variety of thermal therapy systems including high-intensity focused ultrasound (HiFU), interstitial ultrasound applicators and lasers.  For the laser work we have also used gold nanoshell technologies to enhance the heating and improve the heat distribution patterns in collaboration with scientists at Rice University (Drs. Naomi Halas and Jennifer West) and with Nanospectra Biosciences.  Most recently, we partnered with Drs. Tinsley Oden (Center for Advanced Computation and Engineering Science) and Ken Diller (Biomedical Engineering) from the University of Texas at Austin to develop a dynamic, closed-loop system for managing heat-shock protein expressing using real-time MRTI feedback.  Work in the lab has been funded by NCI, NIBIB and NSF.

I am also the Director of the Small Animal Imaging Facility (SAIF), an institutional research resource partially funded by the Cancer Center Support Grant (P30 CA16672).  The SAIF is a facility available to all faculty at M. D. Anderson for imaging mice and rats.  SAIF instrumentation includes MR (4.7 and 7.0 T Bruker Biospec systems), nuclear (planar gamma camera with SPECT capability and a micro-PET), x-ray computed tomography (micro-CT and speciment CT), high-resolution projection radiography (digital Faxitron), micro-ultrasound (Vevo 770) and optical (Xenogen Spectrum bioluminescence-biofluorescence).  Services available through SAIF include consultation on imaging protocols, assistance with experimental design and image analysis support.  Novel technologies currently being implemented include hyperpolarized MR spectroscopy with Dr. Jim Bankson, photo-acoustic imaging with Drs. Richard Bouchard and Kostia Sokolov and nano-magneto elaxometry with Dr. Bob Bast.

Office Address

The University of Texas MD Anderson Cancer Center
Department of Imaging Physics - Unit 1472
1400 Pressler St.
Houston, TX 77030-4009
Room Number: FCT14.6044
Phone: (713) 792-0612
Fax: (713) 745-0581
Email: jhazle@mdanderson.org

Education & Training

Degree-Granting Education

1989 The University of Texas Graduate School of Biomedical Sciences, Houston, TX, PHD, Biophysics
1983 University of Kentucky, Lexington, Lexington, KY, MS, Medical Physics
1981 University of Kentucky, Lexington, KY, BS, Physics

Board Certifications

1998 American Board of Medical Physics (MRI Physics)
1996 American Board of Radiology (Diagnostic Radiologic Physics)
1992 American Board of Radiology (Therapeutic Radiological Physics)

Honors and Awards

2014 President's Recognition for Faculty Excellence, UT M.D. Anderson Cancer Center
2011 Fellow, American College of Radiology
2007 Certificate of Excellence in Research Mentorship, University of Texas Center for Biomedical Engineering
2007 Outstanding Alumni Award, The University of Kentucky College of Health Sciences
2005 Certificate of Excellence in Research Mentorship, University of Texas Center for Biomedical Engineering
2004 Certificate of Excellence in Research Mentorship, University of Texas Center for Biomedical Engineering
2003 Fellow, American Association of Physicists in Medicine
1999 Tenure, The University of Texas M. D. Anderson Cancer Center
1998 Re-appointment with Commendation, Graduate School of Biomedical Sciences
1996 Cum Laude Award, Radiological Society of North America
1995 Certificate of Merit, Radiological Society of North America
1995 Certificate of Merit, Radiological Society of North America
1995 Student Marshal, Graduation Ceremony, Graduate School of Biomedical Sciences
1994-2001 Dean’s Excellence Award, Graduate School of Biomedical Sciences, The University of Texas Health Science Center

Selected Publications

Peer-Reviewed Original Research Articles

1. Rambow O, Hazle J, Clark J, Ma J. Direct water and fat determination in two-point Dixon imaging with flexible echo times. Med Phys 40(11):112302, 11/2013. PMID: 24320458.
2. Fahrenholtz SJ, Stafford RJ, Maier F, Hazle JD, Fuentes D. Generalised polynomial chaos-based uncertainty quantification for planning MRgLITT procedures. Int J Hyperthermia 29(4):324-335, 6/2013. PMCID: PMC3924420.
3. Mitcham T, Homan K, Frey W, Chen YS, Emelianov S, Hazle J, Bouchard R. Modulation of photoacoustic signal generation from metallic surfaces. J Biomed Opt 18(5):56008, 5/2013. PMCID: PMC3646486.
4. Fuentes D, Elliott A, Weinberg JS, Shetty A, Hazle JD, Stafford RJ. An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Monitoring of MR-Guided Laser Induced Thermal Therapy. Ann Biomed Eng 41(1):100-11, 1/2013. e-Pub 8/2012. PMCID: PMC3524364.
5. Ku G, Zhou M, Song S, Huang Q, Hazle J, Li C. Copper Sulfide Nanoparticles as a New Class of Photoacoustic Contrast Agent for Deep Tissue Imaging at 1064-nm. ACS Nano 6(8):7489-7496, 8/2012. e-Pub 7/2012. PMCID: PMC3429766.
6. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell 149(5):1098-111, 5/2012. PMCID: PMC3586339.
7. Fuentes D, Oden JT, Diller KR, Hazle JD, Elliott A, Shetty A, Stafford RJ. Computational modeling and real-time control of patient-specific laser treatment of cancer. Ann Biomed Eng 37(4):763-82, 4/2009. e-Pub 1/2009. PMID: 19148754.
8. Taylor BA, Hwang KP, Hazle JD, Stafford RJ. Autoregressive moving average modeling for special parameter estimation from a multigradient echo chemical shift acquisition. Med Phys 36(3):753-764, 3/2009. PMCID: PMC2736745.
9. Taylor BA, Hwang KP, Elliott AM, Shetty A, Hazle JD, Stafford RJ. Dynamic chemical shift imaging for image-guided thermal therapy: analysis of feasibility and potential. Med Phys 35(2):793-803, 2008. PMID: 18383702.
10. Diagaradjane P, Shetty A, Wang JC, Elliott AM, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford RJ, Cho SH, Tunnell JW, Hazle JD, Krishnan S. Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Letters 8(5):1492-500, 2008. PMCID: PMC3952070.
11. Ross W, Cody DD, Hazle JD. Design and performance characteristics of a digital flat-panel computed tomography system. Med Phys 33:1888-901, 2006. PMID: 16872096.
12. Stafford RJ, Hazle JD. Magnetic resonance temperature imaging for focused ultrasound surgery: a review. Top Magn Reson Imaging 17/3:153-63, 2006. PMID: 17414072.
13. Bankson JA, Stafford RJ, Hazle JD. Partially parallel imaging with phase-sensitive data: Increased temporal resolution for magnetic resonance temperature imaging. Magn Reson Med 53/3:658-65, 2005. PMID: 15723414.

Last updated: 4/15/2014