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John N. Weinstein, MD, PhD

Present Title & Affiliation

Primary Appointment

Professor and Chair, Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit 1410
Unit Number: 1410
Houston, TX 77030
Room Number: FCT4.5024
Fax: 713-563-4242
Email: jweinste@mdanderson.org

Education & Training

Degree-Granting Education

1971 Harvard Medical School, Boston, MA, MD, General Medicine
1971 Harvard University, Cambridge, MA, PHD, Biophysics
1964 Harvard University, Cambridge, MA, BA, Biology

Postgraduate Training

1973 Residency in Medicine, Stanford University Medical Center, Stanford, CA
1972 Internship in Medicine, Stanford University Medical Center, Stanford, CA

Honors and Awards

2006 Director's Innovation Award, National Cancer Institute
2006 Technology Transfer Award
2006 Undergraduate Scholarship Program Recognition Award, National Institutes of Health
2005 CLAS Distinguished Scientist Award
2004 Nominee, Institute of Medicine of the National Academy of Sciences
2004 Nominee, National Medal of Technology
2002 General Motors Lecturer
1999 Public Health Service Meritorious Service Medal
1998 NCI Intramural Research Award, NCI
1996 NIH Commendation Medal, NIH
1995-1997 Equal Employment Opportunity Officer's Awards
1988 Public Health Service Outstanding Service Medal
1987 Creasy Memorial Lectureship, Sloan-Kettering and Cornell Medical School
1960-1964 Honorary National Scholarship
1960-1961 Harvard College Scholarship

Selected Publications

Peer-Reviewed Original Research Articles
1. Deus HF, Veiga DF, Freire PR, Weinstein JN, Mills GB, Almeida JS. Exposing The Cancer Genome Atlas as a SPARQL endpoint. J Biomed Inform 43(6):998-1008, 12/2010. e-Pub 9/2010. PMCID: PMC3071752.
2. Kahn AB, Zeeberg BR, Ryan MC, Jamison DC, Rockoff DM, Pommier Y, Weinstein JN. Ontogenomic study of the relationship between number of gene splice variants and GO categorization. Bioinformatics 26(16):1945-9, 8/2010. e-Pub 7/2010. PMCID: PMC2916722.
3. Lu JJ, Meng LH, Shankavaram UT, Zhu CH, Tong LJ, Chen G, Lin LP, Weinstein JN, Ding J. Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells. Biochem Pharmacol 80(1):22-30, 7/2010. e-Pub 3/2010. PMID: 20206143.
4. Liu H, D'Andrade P, Fulmer-Smentek S, Lorenzi P, Kohn KW, Weinstein JN, Pommier Y, Reinhold WC. mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities. Mol Cancer Ther 9(5):1080-91, 5/2010. e-Pub 5/2010. PMCID: PMC2879615.
5. Reinhold WC, Mergny JL, Liu H, Ryan M, Pfister TD, Kinders R, Parchment R, Doroshow J, Weinstein JN, Pommier Y. Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res 70(6):2191-203, 3/2010. e-Pub 3/2010. PMID: 20215517.
6. Hanczar B, Hua J, Sima C, Weinstein JN, Bittner M, Dougherty ER. Small-sample precision of ROC-related estimates. Bioinformatics 26(6):822-30, 3/2010. e-Pub 2/2010. PMID: 20130029.
7. Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA. Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set. Mol Cancer Ther 9(2):257-67, 2/2010. e-Pub 2/2010. PMID: 20124458.
8. Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN. Multifactorial regulation of E-cadherin expression: an integrative study. Mol Cancer Ther 9(1):1-16, 1/2010. e-Pub 1/2010. PMCID: PMC2821037.
9. Orina JN, Calcagno AM, Wu CP, Varma S, Shih J, Lin M, Eichler G, Weinstein JN, Pommier Y, Ambudkar SV, Gottesman MM, Gillet JP. Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Mol Cancer Ther 8(7):2057-66, 7/2009. e-Pub 7/2009. PMCID: PMC2736804.
10. Kohn KW, Aladjem MI, Weinstein JN, Pommier Y. Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis. Cell Cycle 8(14):1-18, 7/2009. e-Pub 7/2009. PMID: 19556879.
11. Lorenzi PL, Reinhold WC, Varma S, Hutchinson AA, Pommier Y, Chanock SJ, Weinstein JN. DNA fingerprinting of the NCI-60 cell line panel. Mol Cancer Ther 8(4):713-24, 4/2009. e-Pub 4/2009. PMID: 19372543.
12. Lorenzi PL, Weinstein JN. Asparagine Synthetase: a new potential biomarker in ovarian cancer. Drug News Perspect 22(1):61, Jan-Feb, 1/2009. PMID: 19209300.
13. Shankavaram UT, Varma S, Kane D, Sunshine M, Chary KK, Reinhold WC, Pommier Y, Weinstein JN. CellMiner: a relational database and query tool for the NCI-60 cancer cell lines. BMC Genomics 10:277, 2009. PMCID: PMC2709662.
14. Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, Kirsch IR. Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance. Neoplasia 10(11):1222-30, 11/2008. PMCID: PMC18953431.
15. Lorenzi PL, Llamas J, Gunsior M, Ozbun L, Reinhold WC, Varma S, Ji H, Kim H, Hutchinson AA, Kohn EC, Goldsmith PK, Birrer MJ, Weinstein JN. Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines. Mol Cancer Ther 7(10):3123-8, 10/2008. PMCID: PMC18852115.
16. Okabe M, Szakacs G, Reimers MA, Suzuki T, Hall MD, Abe T, Weinstein JN, Gottesman MM. Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol Cancer Ther 7(9):3081-91, 9/2008. PMCID: PMC18790787.
17. Ikediobi ON, Reimers M, Durinck S, Blower PE, Futreal AP, Stratton MR, Weinstein JN. In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation. Mol Cancer Ther 7(6):1337-46, 6/2008. PMID: 18524847.
18. Ruden DM, Jamison DC, Zeeberg BR, Garfinkel MD, Weinstein JN, Rasouli P, Lu X. The EDGE hypothesis: epigenetically directed genetic errors in repeat-containing proteins (RCPs) involved in evolution, neuroendocrine signaling, and cancer. Frontiers in Neuroendocrinology 29(3):428-44, 6/2008. PMID: 18295320.
19. Weinstein JN. A postgenomic visual icon. Science 319(5871):1772-3, Nov-Dec, 3/2008. PMID: 18369130.
20. Boersma BJ, Reimers M, Yi M, Ludwig JA, Luke BT, Stephens RM, Yfantis HG, Lee DH, Weinstein JN, Ambs S. A stromal gene signature associated with inflammatory breast cancer. Int J Cancer 122(6):1324-32, Nov-Dec, 3/2008. PMID: 17999412.
21. Ashworth A, Balkwill F, Bast RC, Berek JS, Kaye A, Boyd JA, Mills G, Weinstein JN, Woolley K, Workman P. Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007. Gynecol Oncol 108(3):652-7, 3/2008. PMID: 18096210.
22. Patterson AD, Li H, Eichler GS, Krausz KW, Weinstein JN, Fornace AJ Jr, Gonzalez FJ, Idle JR. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem 80(3):665-74, Nov-Dec, 2/2008. PMID: 18173289.
23. Kohn KW, Aladjem MI, Weinstein JN, Pommier Y. Chromatin challenges during DNA replication: a systems representation. Mol Biol Cell 19(1):1-7, Nov-Dec, 1/2008. PMID: 17959828.
24. Amundson SA, Do KT, Vinikoor LC, Lee RA, Koch-Paiz CA, Ahn J, Reimers M, Chen Y, Scudiero DA, Weinstein JN, Trent JM, Bittner ML, Meltzer PS, Fornace AJ Jr. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res 68(2):415-24, 1/2008. PMID: 18199535.
25. Blower PE, Chung JH, Verducci JS, Lin S, Park JK, Dai Z, Liu CG, Schmittgen TD, Reinhold WC, Croce CM, Weinstein JN, Sadee W. MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther 7(1):1-9, Nov-Dec, 1/2008. PMID: 18187804.
26. Stevens EV, Nishizuka S, Antony S, Reimers M, Varma S, Young L, Munson PJ, Weinstein JN, Kohn EC, Pommier Y. Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers. Mol Cancer Ther 7(1):10-8, Nov-Dec, 1/2008. PMID: 18187810.
27. Sheehan KM, Gulmann C, Eichler GS, Weinstein JN, Barrett HL, Kay EW, Conroy RM, Liotta LA, Petricoin EF 3rd. Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition. Oncogene 27(3):323-31, 10 Jan 2008, 1/2008. PMCID: PMC17621268.
28. The Cancer Genome Atlas Research Network (including Weinstein JN). Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216):1061-8, 2008. PMCID: PMC2671642.
29. Sheehan KM, Gulmann C, Eichler GS, Weinstein JN, Barrett HL, Kay EW, Conroy RM, Liotta LA, Petricoin EF III. Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition. Oncogene 27(3):323-31, 2008. PMID: 17621268.
30. Ryan MC, Zeeberg BR, Caplen NJ, Cleland JA, Kahn AB, Liu H, Weinstein JN. SpliceCenter: a suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies. BMC Bioinformatics 9:313, 2008. PMCID: PMC2491637.
31. Kestler HA, Muller A, Buchholz M, Gress TM, Liu H, Kane DW, Zeeberg BR, Weinstein JN. VennMaster: area-proportional Euler diagrams for functional GO analysis of microarrays. BMC Bioinformatics 9:67, 2008. PMCID: PMC2335321.
32. Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein DJ, Weinstein JN, Pommier Y. Nonclassical functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Res 67(18):8752-61, 9/2007. PMID: 17875716.
33. Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN. Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells. Mol Cancer Ther 6(2):391-403, 2/2007. PMID: 17272646.
34. Lee JK, Havaleshko DM, Cho HJ, Weinstein JN, Karpovich J, Grimshaw A, Theodorescu D. A new strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc. Natl. Acad. Sci. U.S.A. 2007 104:13086-91, 2007.
35. Liu H, Zeeberg BR, Qu G, Koru AG, Ferrucci A, Kahn A, Ryan MC, Nuhanovic A, Munson PJ, Reinhold WC, Kane DW, Weinstein JN. AffyProbeMiner: a web resource for computing or retrieving accurately redefined Affymetrix probe sets. Bioinformatics 23(18):2385-90, 2007. PMID: 17660211.
36. Blower PE, Verducci JS, Lin S, Zhou J, Chung JH, Dai Z, Liu CG, Reinhold W, Lorenzi PL, Kaldjian EP, Croce CM, Weinstein JN, Sadee W. MicroRNA expression profiles for the NCI-60 cancer cell panel. Mol Cancer Ther 6(5):1483-91, 2007. PMID: 17483436.
37. Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ. Multiplexing siRNAs to compress RNAi-based screen size in human cells. Nucleic Acids Res 35(8):e57, 2007. PMID: 17392344.
38. Kahn AB, Ryan MC, Liu H, Zeeberg BR, Jamison DC, Weinstein JN. SpliceMiner: A High-Throughput Database Implementation of the NCBI Evidence Viewer for Microarray Splice Variant Analysis. BMC Bioinformatics 8:75, 2007. PMID: 17338820.
39. Eichler GS, Reimers M, Kane D, Weinstein JN. The LeFE algorithm: Embracing the complexity of gene expression in the interpretation of microarray data. Genome Biol 8(9):R187, 2007. PMID: 17845722.
40. Shankavaram UT, Reinhold WC, Nishizuka S, Major S, Morita D, Chary KK, Reimers MA, Scherf U, Kahn A, Dolginow D, Cossman J, Kaldjian EP, Scudiero DA, Petricoin E, Liotta L, Lee JK, Weinstein JN. Transcript and protein expression profiles of the NCI-60 cancer cell panel: An integromic microarray study. Mol Cancer Ther 6(3):820-3, 2007. PMID: 17339364.
41. Weinstein JN, Pommier Y. Connecting genes, drugs and diseases. Nat Biotechnol 24(11):1365-6, 11/2006. PMID: 17093484.
42. Weinstein JN. Spotlight on molecular profiling: "Integromic" analysis of the NCI-60 cancer cell lines. Mol Cancer Ther 5(11):2601-5, 11/2006. PMID: 17088435.
43. Riss J, Khanna C, Koo S, Chandramouli GV, Yang HH, Hu Y, Kleiner DE, Rosenwald A, Schaefer CF, Ben-Sasson SA, Yang L, Powell J, Kane DW, Star RA, Aprelikova O, Bauer K, Vasselli JR, Maranchie JK, Kohn KW, Buetow KH, Linehan WM, Weinstein JN, Lee MP, Klausner RD, Barrett JC. Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. Cancer Res 66(14):7216-24, 7/2006. PMID: 16849569.
44. Ludwig JA, Szakács G, Martin SE, Chu BF, Cardarelli C, Sauna ZE, Caplen NJ, Fales HM, Ambudkar SV, Weinstein JN, Gottesman MM. Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Res 66(9):4808-15, Mar-Apr, 5/2006. PMID: 16651436.
45. Major SM, Nishizuka S, Morita D, Rowland R, Sunshine M, Shankavaram U, Washburn F, Asin D, Kouros-Mehr H, Kane D, Weinstein JN. AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. BMC Bioinformatics 7:192, Mar-Apr, 2006. PMID: 16600027.
46. Meng L-H, Shankavaram U, Chen C, Agama K, Fu H-Q, Gonzalez FJ, Weinstein JN, Pommier Y. Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX. Cancer Res 66(19):9656-64, 2006. PMID: 17018623.
47. Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. Mol Cancer Ther 5(11):2613-23, 2006. PMID: 17088436.
48. Pommier Y, Weinstein JN, Aladjem MI, Kohn KW. Chk2 molecular interaction map and rationale for Chk2 inhibitors. Clin Cancer Res 12(9):2657-61, 2006. PMID: 16675556.
49. Blower PE, Cross KP, Eichler GS, Myatt GJ, Weinstein JN, Yang C. Comparison of methods for sequential screening of large compound sets. Comb Chem High Throughput Screen 9(2):115-22, Mar-Apr, 2006. PMID: 16475969.
50. Kohn KW, Aladjem MI, Kim S, Weinstein JN, Pommier Y. Depicting combinatorial complexity with the molecular interaction map notation. Mol Syst Biol 2:51, Mar-Apr, 2006. PMID: 17016517.
51. Bussey KJ, Chin K, Lababidi S, Reimers M, Reinhold WC, Kuo WL, Gwadry F, Ajay F, Kouros-Mehr H, Fridlyand J, Jain A, Collins C, Nishizuka S, Tonon G, Roschke A, Gehlhaus K, Kirsch I, Scudiero DA, Gray JW, Weinstein JN. Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther 5(4):853-67, Mar-Apr, 2006. PMID: 16648555.
52. Kohn KW, Aladjem MI, Weinstein JN, Pommier Y. Molecular interaction maps of bioregulatory networks: a general rubric for systems biology. Mol Biol Cell 17(1):1-13, Mar-Apr, 2006. PMID: 16267266.
53. Ikediobi ON, Davies H, Bignell G, Edkins S, Stevens C, O'Meara S, Santarius T, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Hunter C, Jenkinson A, Jones D, Kosmidou V, Lugg R, Menzies A, Mironenko T, Parker A, Perry J, Raine K, Richardson D, Shepherd R, Small A, Smith R, Solomon H, Stephens P, Teague J, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Reinhold W, Weinstein JN, Stratton MR, Futreal PA, Wooster R. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther 5(11):2606-12, 2006. PMID: 17088437.
54. Morin RD, Chang E, Petrescu A, Liao N, Griffith M, Chow W, Kirkpatrick R, Butterfield YS, Young AC, Stott J, Barber S, Babakaiff R, Dickson MC, Matsuo C, Wong D, Yang GS, Smailus DE, Wetherby KD, Kwong PN, Grimwood J, Brinkley CP, Brown-John M, Reddix-Dugue ND, Mayo M, Schmutz J, Beland J, Park M, Gibson S, Olson T, Bouffard GG, Tsai M, Featherstone R, Chand S, Siddiqui AS, Jang W, Lee E, Klein SL, Blakesley RW, Zeeberg BR, Narasimhan S, Weinstein JN, Pennacchio CP, Myers RM, Green ED, Wagner L, Gerhard DS, Marra MA, Jones SJ, Holt RA. Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Genome Res 16(6):796-803, 2006. PMCID: PMC1479861.
55. Lotze MT, Wang E, Marincola F, Hanna N, Panelli MC, Weinstein JN, Perricone MA, Shivers SC, Bugelski J, Sauter G, Burns CA, Howell M, Damle N, Taylor L, Godfrey T, Petricoin E, Scheibenbogen C, Whiteside TL, Coukos G. Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. J Immunother 28(2):79-119, 3/2005. PMID: 15725954.
56. Roschke AV, Lababidi S, Tonon G, Gehlhaus KS, Bussey K, Weinstein JN, Kirsch IR. Karyotypic "state" as a potential determinant for anticancer drug discovery. Proc Natl Acad Sci U S A 102(8):2964-9, 2/2005. PMID: 15703300.
57. Ludwig JA, Weinstein JN. Biomarkers in cancer staging, prognosis, and treatment selection. Nat Rev Cancer 5(11):845-56, Mar-Apr, 2005. PMID: 16239904.
58. Zeeberg BR, Qin H, Narasimhan S, Sunshine M, Cao H, Kane DW, Reimers M, Stephens RM, Bryant D, Burt SK, Elnekave E, Hari DM, Wynn TA, Cunningham-Rundles C, Stewart DM, Nelson D, Weinstein JN. High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID). BMC Bioinformatics 6:168, 2005. PMCID: PMC1190154.
59. Fojo T, Farrell N, Ortuzar W, Tanimura H, Weinstein JN, Myers TG. Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations. Crit Rev Oncol Hematol 53(1):25-34, 2005. PMID: 15607933.
60. Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, Wang H, Clark T, Fraser C, Ruggiu M, Zeeberg BR, Kane D, Weinstein JN, Blume J, Darnell RB. Nova regulates brain-specific splicing to shape the synapse. Nat Genet 37(8):844-52, Mar-Apr, 2005. PMID: 16041372.
61. Reimers M, Weinstein JN. Quality assessment of microarrays: visualization of spatial artifacts and quantitation of regional biases. BMC Bioinformatics 6:166, Mar-Apr, 2005. PMID: 15992406.
62. Staib F, Robles AI, Varticovski L, Wang XW, Zeeberg BR, Sirotin M, Zhurkin VB, Hofseth LJ, Hussain SP, Weinstein JN, Galle PR, Harris CC. The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Cancer Res 65(22):10255-64, Mar-Apr, 2005. PMID: 16288013.
63. Petersen D, Gadisetti C, Geoghegan J, Hilburn J, Paarlberg J, Kim CH, Munroe D, Gangi L, Han J, Puri R, Staudt L, Weinstein JN, Barrett JC, Green J, Kawasaki ES. Three microarray platforms: an analysis of their concordance in profiling gene expression. BMC Genomics 6(1):63, 2005. PMCID: PMC1140753.
64. Reimers M, Weinstein JN. Visualization of spatial artifacts and quantitation of regional biases. BMC Bioinformatics 6:166, 2005. PMCID: PMC1189079.
65. Annereau JP, Szakács G, Tucker CJ, Arciello A, Cardarelli C, Collins J, Grissom S, Zeeberg BR, Reinhold W, Weinstein JN, Pommier Y, Paules RS, Gottesman MM. Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance. Mol Pharmacol 66(6):1397-405, Oct-Nov, 12/2004. PMID: 15342794.
66. Aladjem MI, Pasa S, Parodi S, Weinstein JN, Pommier Y, Kohn KW. Molecular interaction maps--a diagrammatic graphical language for bioregulatory networks. Sci STKE 222:pe8, 3/2004. PMID: 14997004.
67. Weinstein JN, Nishizuka S, Reinhold WC, Bussey K, Kim S, Major S, Lababidi S, Feng W, Wang G, Raffeld M, Sunshine M, Narasimhan S, Zeeberg B, Wang M, Lee JK, Kane D. Cancer drug discovery: Genomics, Proteomics, and Bioinformatics. Molecular Target Therapy of Cancer 1, 2004.
68. Weinstein JN. Integromic analysis of the NCI-60 cancer cell lines. Breast Dis 19:11-22, Oct-Nov, 2004. PMID: 15687693.
69. Mulshine JL, Weinstein JN. Is the gene expression pattern of lung cancer detected by screening with spiral computed tomography different from that of symptom-detected lung cancer? Clin Cancer Res 10(18 Pt 1):5973-4, Oct-Nov, 2004. PMID: 15447979.
70. Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadée W. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 64(12):4294-301, Oct-Nov, 2004. PMID: 15205344.
71. Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, Barrett JC, Weinstein JN. Mistaken identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics. BMC Bioinformatics 5:80, Oct-Nov, 2004. PMID: 15214961.
72. Szakacs G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN, Gottesman MM. Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells. Cancer Cell 6(2):129-37, Oct-Nov, 2004. PMID: 15324696.
73. Kohn KW, Riss J, Aprelikova O, Weinstein JN, Pommier Y, Barrett JC. Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system. Mol Biol Cell 15(7):3042-52, Oct-Nov, 2004. PMID: 15107465.
74. Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN, Kirsch IR. Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63(24):8634-47, Oct-Nov, 12/2003. PMID: 14695175.
75. Nishizuka S, Charboneau L, Young L, Major S, Reinhold WC, Waltham M, Kouros-Mehr H, Bussey KJ, Lee JK, Espina V, Munson PJ, Petricoin E, Liotta LA, Weinstein JN. Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proc Natl Acad Sci U S A 100(24):14229-34, Oct-Nov, 11/2003. PMID: 14623978.
76. Weinstein JN, Pommier Y. Transcriptomic analysis of the NCI-60 cancer cell lines. C R Biol 326(10-11):909-20, Oct-Nov, 10/2003. PMID: 14744097.
77. Nishizuka S, Chen ST, Gwadry FG, Alexander J, Major SM, Scherf U, Reinhold WC, Waltham M, Charboneau L, Young L, Bussey KJ, Kim S, Lababidi S, Lee JK, Pittaluga S, Scudiero DA, Sausville EA, Munson PJ, Petricoin EF, Liotta LA, Hewitt SM, Raffeld M, Weinstein JN. Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling. Cancer Res 63(17):5243-50, 9/2003. PMID: 14500354.
78. Yoshida A, Urasaki Y, Waltham M, Bergman AC, Pourquier P, Rothwell DG, Inuzuka M, Weinstein JN, Ueda T, Appella E, Hickson ID, Pommier Y. Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. J Biol Chem 278(39):37768-76, 9/2003. PMID: 12842873.
79. Daoud SS, Munson PJ, Reinhold W, Young L, Prabhu VV, Yu Q, LaRose J, Kohn KW, Weinstein JN, Pommier Y. Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study. Cancer Res 63(11):2782-93, 6/2003. PMID: 12782583.
80. Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y, Weinstein JN. Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping. Cancer Res 63(5):1000-11, 3/2003. PMID: 12615715.
81. Lee JK, Bussey KJ, Gwadry FG, Reinhold W, Riddick G, Pelletier SL, Nishizuka S, Szakacs G, Annereau JP, Shankavaram U, Lababidi S, Smith LH, Gottesman MM, Weinstein JN. Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells. Genome Biol 4(12):R82, 2003. PMID: 14659019.
82. Feng W, Wang G, Zeeberg BR, Guo K, Fojo AT, Kane DW, Reinhold WC, Lababidi S, Weinstein JN, Wang MD. Development of gene ontology tool for biological interpretation of genomic and proteomic data. AMIA Annu Symp Proc:839, 2003. PMID: 14728344.
83. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, Bussey KJ, Riss J, Barrett JC,Weinstein JN. GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4(4):R28, May-Jun, 2003. PMID: 12702209.
84. Kim S, Weinstein JN, Grefenstette JJ. Inference of large-scale topology of gene regulation networks by neural nets. Proc. IEEE International Conference of Systems, Man, and Cybernetics:3969-75, 2003.
85. Bussey KJ, Kane D, Sunshine M, Narasimhan S, Nishizuka S, Reinhold WC, Zeeberg B, Ajay W, Weinstein JN. MatchMiner: a tool for batch navigation among gene and gene product identifiers. Genome Biol 4(4):R27, May-Jun, 2003. PMID: 12702208.
86. Weinstein JN. 'Omic' and hypothesis-driven research in the molecular pharmacology of cancer. Curr Opin Pharmacol 2(4):361-5, May-Jun, 8/2002. PMID: 12127867.
87. Zhou Y, Gwadry FG, Reinhold WC, Miller LD, Smith LH, Scherf U, Liu ET, Kohn KW, Pommier Y, Weinstein JN. Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects. Cancer Res 62(6):1688-95, May-Jun, 3/2002. PMID: 11912141.
88. Weinstein JN, Scherf U, Lee JK, Nishizuka S, Gwadry F, Bussey AK, Kim S, Smith LH, Tanabe L, Richman S, Alexander J, Kouros-Mehr H, Maunakea A, Reinhold WC. The bioinformatics of microarray gene expression profiling. Cytometry 47(1):46-9, May-Jun, 1/2002. PMID: 11774349.
89. Blower PE, Yang C, Fligner MA, Verducci JS, Yu L, Richman S, Weinstein JN. Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J 2(4):259-71, May-Jun, 2002. PMID: 12196914.
90. Staunton JE, Slonim DK, Coller HA, Tamayo P, Angelo MJ, Park J, Scherf U, Lee JK, Reinhold WO, Weinstein JN, Mesirov JP, Lander ES, Golub TR. Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A 98(19):10787-92, May-Jun, 9/2001. PMID: 11553813.
91. Fan Y, Shi LM, Kohn KW, Pommier Y, Weinstein JN. Quantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studies. J Med Chem 44(20):3254-63, May-Jun, 9/2001. PMID: 11563924.
92. Viswanadhan VN, Mueller GA, Basak SC, Weinstein JN. Comparison of a neural net-based QSAR algorithm (PCANN) with Hologram- and multiple linear regression-based QSAR approaches: application to 1,4-dihydropyridine-based calcium channel antagonists. J Chem Inf Comput Sci 41(3):505-11, May-Jun, 5/2001. PMID: 11410024.
93. Weinstein JN. Searching for pharmacogenomic markers: the synergy between omic and hypothesis-driven research. Dis Markers 17(2):77-88, Mar-Apr, 2001. PMID: 11673654.
94. Buckner JC, Moynihan TJ, Quinn DI, Schlegel U, Ali-Osman F, Srivenugopal K, Sawaya R, Esteller M, Herman JG, Weinstein JN. The DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents. NEJM 344:686-88 (commentary), 2001.
95. Lisziewicz J, Zeng G, Gratas C, Weinstein JN, Lori F. Combination gene therapy: synergistic inhibition of human immunodeficiency virus Tat and Rev functions by a single RNA molecule. Hum Gene Ther 11(6):807-15, Mar-Apr, 4/2000. PMID: 10779158.
96. Scherf U, Ross DT, Waltham M, Smith LH, Lee JK, Tanabe L, Kohn KW, Reinhold WC, Myers TG, Andrews DT, Scudiero DA, Eisen MB, Sausville EA, Pommier Y, Botstein D, Brown PO, Weinstein JN. A gene expression database for the molecular pharmacology of cancer. Nat Genet 24(3):236-44, Sep-Oct, 3/2000. PMID: 10700175.
97. Shi LM, Fan Y, Lee JK, Waltham M, Andrews DT, Scherf U, Paull KD, Weinstein JN. Mining and visualizing large anticancer drug discovery databases. J Chem Inf Comput Sci 40(2):367-79, Mar-Apr, 3/2000. PMID: 10761142.
98. Weinstein JN, Buolamwini JK. Molecular targets in cancer drug discovery: cell-based profiling. Curr Pharm Des 6(4):473-83, Mar-Apr, 3/2000. PMID: 10788592.
99. Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO. Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 24(3):227-35, Sep-Oct, 3/2000. PMID: 10700174.
100. Rindflesch TC, Tanabe L,Weinstein JN, Hunter L. EDGAR: extraction of drugs, genes and relations from the biomedical literature. Pac Symp Biocomput:517-28, Sep-Oct, 2000. PMID: 10902199.
101. van Osdol WW, Myers TG, Weinstein JN. Neural network techniques for informatics of cancer drug discovery. Methods Enzymol 321:369-95, Sep-Oct, 2000. PMID: 10909067.
102. Tanabe L, Scherf U, Smith LH, Lee JK, Hunter L, Weinstein JN. MedMiner: an Internet text-mining tool for biomedical information, with application to gene expression profiling. Biotechniques 27(6):1210-4, 1216-7, Sep-Oct, 12/1999. PMID: 10631500.
103. Carrier F, Georgel PT, Pourquier P, Blake M, Kontny HU, Antinore MJ, Gariboldi M, Myers TG, Weinstein JN, Pommier Y, Fornace AJ. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 19(3):1673-85, 3/1999. PMID: 10022855.
104. Fornace Jr. AJ, Amundson SA, Bittner M, Myers TG, Meltzer P, Weinstein JN, Trent J. The complexity of radiation stress responses: Analysis by informatics and functional genomics approaches. Gene Expression 7:387-400, 1999.
105. Weinstein JN. Fishing expeditions. Science 282(5389):628-9, 10/1998. PMID: 9841413.
106. Fan Y, Weinstein JN, Kohn KW, Shi LM, Pommier Y. Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. J Med Chem 41(13):2216-26, Mar-Apr, 6/1998. PMID: 9632354.
107. Shi LM, Fan Y, Myers TG, O'Connor PM, Paull KD, Friend SH, Weinstein JN. Mining the NCI anticancer drug discovery databases: genetic function approximation for the QSAR study of anticancer ellipticine analogues. J Chem Inf Comput Sci 38(2):189-99, Mar-Apr, 3/1998. PMID: 9538518.
108. Shi LM, Myers TG, Fan Y, O'Connor PM, Paull KD, Friend SH, Weinstein JN. Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity. Mol Pharmacol 53(2):241-51, Mar-Apr, 2/1998. PMID: 9463482.
109. O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, Scudiero DA, Monks A, Sausville EA, Weinstein JN, Friend S, Fornace AJ, Kohn KW. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 57(19):4285-300, Mar-Apr, 10/1997. PMID: 9331090.
110. Wosikowski K, Schuurhuis D, Johnson K, Paull KD, Myers TG, Weinstein JN, Bates SE. Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns. J Natl Cancer Inst 89(20):1505-15, Mar-Apr, 10/1997. PMID: 9337347.
111. Myers TG, Anderson NL, Waltham M, Li G, Buolamwini JK, Scudiero DA, Paull KD, Sausville EA, Weinstein JN. A protein expression database for the molecular pharmacology of cancer. Electrophoresis 18(3-4):647-53, Mar-Apr, 3/1997. PMID: 9150955.
112. Li G, Waltham M, Anderson NL, Unsworth E, Treston A, Weinstein JN. Rapid mass spectrometric identification of proteins from two-dimensional polyacrylamide gels after in gel proteolytic digestion. Electrophoresis 18(3-4):391-402, Mar-Apr, 3/1997. PMID: 9150917.
113. Burke HB, Goodman PH, Rosen DB, Henson DE, Weinstein JN, Harrell FE, Marks JR, Winchester DP, Bostwick DG. Artificial neural networks improve the accuracy of cancer survival prediction. Cancer 79(4):857-62, 2/1997. PMID: 9024725.
114. Weinstein JN, Myers TG, O'Connor PM, Friend SH, Fornace AJ, Kohn KW, Fojo T, Bates SE, Rubinstein LV, Anderson NL, Buolamwini JK, van Osdol WW, Monks AP, Scudiero DA, Sausville EA, Zaharevitz DW, Bunow B, Viswanadhan VN, Johnson GS, Wittes RE, Paull KD. An information-intensive approach to the molecular pharmacology of cancer. Science 275(5298):343-9, 1/1997. PMID: 8994024.
115. Myers TG, Waltham M, Li G, Buolamwini JK, Scudiero DA, Rubinstein LV, Paull KD, Sausville EA, Anderson NL, Weinstein JN. A protein expression database for the molecular pharmacology of cancer. Electrophoresis 18:647-53, 1997.
116. Shi LM, Fan Y, Myers TG, Weinstein JN. Genetic function approximation in the molecular pharmacology of cancer. Symp. Intl. Congress on Neural Networks 1, 1997.
117. Buolamwini JK, Raghavan K, Fesen MR, Pommier Y, Kohn KW, Weinstein JN. Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors. Pharm Res 13(12):1892-5, Nov-Dec, 12/1996. PMID: 8987091.
118. Kawakami M, Tamaki T, Weinstein JN, Hashizume H, Nishi H, Meller ST. Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat. Spine 21(18):2101-7, Nov-Dec, 9/1996. PMID: 8893434.
119. Viswanadhan VN, Mueller GA, Basak SC, Weinstein JN. A new QSAR algorithm combining principal component analysis with a neural network: Application to calcium channel antagonists. NetSci:http://www.netsci.org/Science/Compchem/feature07.html, 1996.
120. Dearing MP, Englee-Miller MJ, Kratzke RA, Kramer BS, Chu E, Weinstein JN, Anderson M, Venzon D, Mulshine JL, Gazdar AF. Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines. J Cell Biochem 24:165-72, 1996.
121. Weinstein JN, Waltham MC, Myers TG. Neural networks in drug discovery. Symp. World Congress on Neural Networks 1, 1996.
122. Casciari JJ, Sato H, Durum SK, Fiege J, Weinstein JN. Reference databases of cytokine structure and function. Cancer Chemother Biol Response Modif 16:315-46, Nov-Dec, 1996. PMID: 8639389.
123. Chokekijchai S, Shirasaka T, Weinstein JN, Mitsuya H. In vitro anti-HIV-1 activity of HIV protease inhibitor KNI-272 in resting and activated cells: implications for its combined use with AZT or ddI. Antiviral Res 28(1):25-38, 9/1995. PMID: 8585758.
124. Saga T, Neumann RD, Heya T, Sato J, Kinuya S, Le N, Paik CH, Weinstein JN. Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc Natl Acad Sci U S A 92(19):8999-9003, 9/1995. PMID: 7568060.
125. Raghavan K, Buolamwini JK, Fesen MR, Pommier Y, Kohn KW, Weinstein JN. Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study. J Med Chem 38(6):890-7, 3/1995. PMID: 7699704.
126. Weinstein JN, Myers TG, Fan Y, Paull KD, Zaharevitz DW, Kohn KW, van Osdol WW. An "information-intensive" strategy for drug discovery at the National Cancer institute: The role of neural networks. Symp. World Congress on Neural Networks 11:750-3, 1995.
127. Alvarez M, Paull K, Hose C, Lee J-S, Weinstein JN, Grever M, Bates S, Fojo T. Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein expression in the cell lines of the NCI anticancer drug screen. J Clinical Investig 95:2205-14, 1995.
128. Weinstein JN, Myers TG. Information resources for liposome research: The drug discovery program of the U.S. National Cancer Institute. J Liposome Research 5:837-44, 1995.
129. Mazumder A, Raghavan K, Weinstein JN, Kohn KW, Pommier Y. Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem Pharmacol 49:1165-70, 1995.
130. Bates SE, Fojo AT, Weinstein JN, Myers TG, Alvarez M, Pauli KD, Chabner BA. Molecular targets in the National Cancer Institute drug screen. J Cancer Res Clin Oncol 121(9-10):495-500, 1995. PMID: 7559726.
131. Casciari JJ, Hollingshead MG, Alley MC, Mayo JG, Malspeis L, Miyauchi S, Grever MR, Weinstein JN. Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model. J Natl Cancer Inst 86(24):1846-52, 12/1994. PMID: 7990159.
132. Chung KN, Paik TH, Roberts S, Kim CH, Kirassova M, Weinstein JN, Trepel JB, Elwood PC. Site-directed mutagenesis of tryptophan residues to conserved hydrophobic residues inhibits the processing of human KB cell folate receptor. Arch Biochem Biophys 315(2):407-14, 12/1994. PMID: 7986085.
133. van Osdol WW, Myers TG, Paull KD, Kohn KW, Weinstein JN. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents. J Natl Cancer Inst 86(24):1853-9, 12/1994. PMID: 7990160.
134. Lori F, Malykh A, Cara A, Sun D, Weinstein JN, Lisziewicz J, Gallo RC. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 266(5186):801-5, 11/1994. PMID: 7973634.
135. Hendrix CW, Flexner C, Szebeni J, Kuwahara S, Pennypacker S, Weinstein JN, Lietman PS. Effect of dipyridamole on zidovudine pharmacokinetics and short-term tolerance in asymptomatic human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother 38(5):1036-40, Mar 15-Apr 15, 5/1994. PMID: 8067734.
136. Sung C, van Osdol WW, Saga T, Neumann RD, Dedrick RL, Weinstein JN. Streptavidin distribution in metastatic tumors pretargeted with a biotinylated monoclonal antibody: theoretical and experimental pharmacokinetics. Cancer Res 54(8):2166-75, Mar 15-Apr 15, 4/1994. PMID: 8174124.
137. Saga T, Weinstein JN, Jeong JM, Heya T, Lee JT, Le N, Paik CH, Sung C, Neumann RD. Two-step targeting of experimental lung metastases with biotinylated antibody and radiolabeled streptavidin. Cancer Res 54(8):2160-5, Mar 15-Apr 15, 4/1994. PMID: 8174123.
138. Koutsoukos AD, Rubinstein LV, Faraggi D, Simon RM, Kalyandrug S, Weinstein JN, Kohn KW, Paull KD. Discrimination techniques applied to the NCI in vitro anti-tumour drug screen: predicting biochemical mechanism of action. Stat Med 13(5-7):719-30, Mar 15-Apr 15, 3/1994. PMID: 8023045.
139. Weinstein JN, Myers T, Buolamwini J, Raghavan K, van Osdol W, Licht J, Viswanadhan VN, Kohn KW, Rubinstein LV, Koutsoukos AD. Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's Drug Discovery Program for Cancer and AIDS. Stem Cells 12(1):13-22, 1/1994. PMID: 8142917.
140. Weinstein JN, Casciari JJ, Raghavan K, Buolamwini J, Myers TG. Neural networks in the biomedical sciences: A survey of 386 publications since the beginning of 1991. Symp. World Congress on Neural Networks 1:121-6, 1994.
141. van Osdol WW, Sung C, Dedrick RL, Weinstein JN. A distributed pharmacokinetic model of two-step imaging and treatment protocols: application to streptavidin-conjugated monoclonal antibodies and radiolabeled biotin. J Nucl Med 34(9):1552-64, 9/1993. PMID: 8355076.
142. Juweid M, Sato J, Paik C, Onay-Basaran S, Weinstein JN, Neumann RD. A simple method for affinity purification of radiolabeled monoclonal antibodies. Nucl Med Biol 20(3):311-5, 4/1993. PMID: 8485490.
143. Betageri GV, Black CD, Szebeni J, Wahl LM, Weinstein JN. Fc-receptor-mediated targeting of antibody-bearing liposomes containing dideoxycytidine triphosphate to human monocyte/macrophages. J Pharm Pharmacol 45(1):48-53, 1/1993. PMID: 8094446.
144. Weinstein JN, Rubinstein LV, Koutsoukos AD, Kohn KW, Grever MR, Monks A, Scudiero DA, Welch L, Chiausa AJ, Fojo AT, Viswanadhan VN, Paull, KD. Neural networks in the discovery of new treatments for cancer and AIDS. Symp. World Congress on Neural Networks 1:111-6, 1993.
145. Juweid M, Neumann R, Paik C, Perez-Bacete MJ, Sato J, van Osdol W, Weinstein JN. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res 52(19):5144-53, Jan-Feb, 10/1992. PMID: 1327501.
146. Weinstein JN, Kohn KW, Grever MR, Viswanadhan VN, Rubinstein LV, Monks AP, Scudiero DA, Welch L, Koutsoukos AD, Chiausa AJ. Neural computing in cancer drug development: predicting mechanism of action. Science 258(5081):447-51, Jan-Feb, 10/1992. PMID: 1411538.
147. Weinstein JN, van Osdol W. Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier". Cancer Res 52(9 Suppl):2747s-2751s, Jan-Feb, 5/1992. PMID: 1563006.
148. Kageyama S, Weinstein JN, Shirasaka T, Kempf DJ, Norbeck DW, Plattner JJ, Erickson J, Mitsuya H. In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations. Antimicrob Agents Chemother 36(5):926-33, Jan-Feb, 5/1992. PMID: 1510415.
149. Weinstein JN, van Osdol W. The macroscopic and microscopic pharmacology of monoclonal antibodies. Int J Immunopharmacol 14(3):457-63, Jan-Feb, 4/1992. PMID: 1618598.
150. Hui TE, Fisher DR, Press OW, Eary JF, Weinstein JN, Badger CC, Bernstein ID. Localized beta dosimetry of 131I-labeled antibodies in follicular lymphoma. Med Phys 19(1):97-104, Jan-Feb, 1/1992. PMID: 1620064.
151. Viswanadhan VN, Denckla B, Weinstein JN. New joint prediction algorithm (Q7-JASEP) improves the prediction of protein secondary structure. Biochemistry 30(46):11164-72, 11/1991. PMID: 1932036.
152. Reddy MR, Viswanadhan VN, Weinstein JN. Relative differences in the binding free energies of human immunodeficiency virus 1 protease inhibitors: a thermodynamic cycle-perturbation approach. Proc Natl Acad Sci U S A 88(22):10287-91, 11/1991. PMID: 1946447.
153. van Osdol W, Fujimori K, Weinstein JN. An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier". Cancer Res 51(18):4776-84, 9/1991. PMID: 1893370.
154. Fujimori K, Fisher DR, Weinstein JN. Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: the radiation dose distribution. Cancer Res 51(18):4821-7, 9/1991. PMID: 1893374.
155. Patel SS, Szebeni J, Wahl LM, Weinstein JN. Differential inhibition of 2'-deoxycytidine salvage as a possible mechanism for potentiation of the anti-human immunodeficiency virus activity of 2',3'-dideoxycytidine by dipyridamole. Antimicrob Agents Chemother 35(6):1250-3, 6/1991. PMID: 1656858.
156. Szebeni J, Weinstein JN. Dipyridamole binding to proteins in human plasma and tissue culture media. J Lab Clin Med 117(6):485-92, 6/1991. PMID: 2045716.
157. Mulshine JL, Carrasquillo JA, Weinstein JN, Keenan AM, Reynolds JC, Herdt J, Bunn PA, Sausville E, Eddy J, Cotelingam JD. Direct intralymphatic injection of radiolabeled 111In-T101 in patients with cutaneous T-cell lymphoma. Cancer Res 51(2):688-95, 1/1991. PMID: 1985786.
158. Szebeni J, Patel SS, Hung K, Wahl LM, Weinstein JN. Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells. Antimicrob Agents Chemother 35(1):198-200, 1/1991. PMID: 2014977.
159. Szebeni J, Dieffenbach C, Wahl SM, Venkateshan CN, Yeh A, Popovic M, Gartner S, Wahl LM, Peterfy M, Friedman RM, Weinstein JN. Induction of interferon- by human immunodeficiency virus type-1 in human monocyte-macrophage cultures. Journal of Virology 65:6362-4, 1991.
160. Ashorn P, Moss B, Weinstein JN, Chaudhary VK, FitzGerald DJ, Pastan I, Berger EA. Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors. Proc Natl Acad Sci U S A 87(22):8889-93, 11/1990. PMID: 1701055.
161. Betageri GV, Szebeni J, Hung K, Patel SS, Wahl LM, Corcoran M, Weinstein JN. Effect of dipyridamole on transport and phosphorylation of thymidine and 3'-azido-3'-deoxythymidine in human monocyte/macrophages. Biochem Pharmacol 40(4):867-70, 8/1990. PMID: 2386551.
162. Fujimori K, Covell DG, Fletcher JE, Weinstein JN. A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier. J Nucl Med 31(7):1191-8, 7/1990. PMID: 2362198.
163. Viswanadhan VN, Ghose AK, Weinstein JN. Mapping the binding site of the nucleoside transporter protein: a 3D-OSAR study. Biochim Biophys Acta 1039(3):356-66, 7/1990. PMID: 2378893.
164. Szebeni J, Wahl SM, Betageri GV, Wahl LM, Gartner S, Popovic M, Parker RJ, Black CD, Weinstein JN. Inhibition of HIV-1 in monocyte/macrophage cultures by 2',3'-dideoxycytidine-5'-triphosphate, free and in liposomes. AIDS Res Hum Retroviruses 6(5):691-702, 5/1990. PMID: 2163269.
165. Weinstein JN. Antibody lymphoscintigraphy. Cancer Treat Res 51:365-85, 1990. PMID: 1977456.
166. Bunow B, Weinstein, JN. Combo: A new approach to the analysis of drug combinations in vitro. Annals NY Acad Sci 616:490-4, 1990.
167. Szebeni J, Wahl SM, Schinazi RF, Popovic M, Gartner S, Wahl LM, Weislow OS, Betageri G, Fine RL, Dahlberg JE, Hunter E, Weinstein JN. Dipyridamole potentiates the aactivity of zidovudine and other dideoxynucleosides against HIV-1 in cultured cells. Annals NY Acad Sci 616:613-6, 1990.
168. Weinstein JN, Schinazi RF, Wahl SM, Bunow B, Garner S, Popovic M, Wahl LM, Weislow OS, Szebeni J. Synergistic drug combinations in AIDS therapy: Dipyridamole-zidovudine in particular and principles of analysis in general. Annals NY Acad Sci 616:367-84, 1990.
169. Fujimori K, Covell DG, Fletcher JE, Weinstein JN. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors. Cancer Res 49(20):5656-63, 10/1989. PMID: 2790783.
170. Szebeni J, Wahl SM, Popovic M, Wahl LM, Gartner S, Fine RL, Skaleric U, Friedmann RM, Weinstein JN. Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages. Proc Natl Acad Sci U S A 86(10):3842-6, 5/1989. PMID: 2542948.
171. Fujimori K, Weinstein JN. Pharmacokinetics and organ targeting of monoclonal antibodies. Advances in Immunopharmacology 4:127-9, 1989.
172. Weinstein JN, Oster DM, Park JB, Park SH, Loening S. The effect of the extracorporeal shock wave lithotriptor on the bone-cement interface in dogs. Clin Orthop Relat Res(235):261-7, 10/1988. PMID: 3416532.
173. Black CD, Kroczek RA, Barbet J, Weinstein JN, Shevach EM. Induction of IL-2 receptor expression in vivo: response to concanavalin A. Cell Immunol 111(2):420-32, Jan-Feb, 2/1988. PMID: 3123074.
174. Borden EC, Bradley EC, Evans CH, Fox CF, Metzgar RS, Mitchell MS, Weinstein JN. Biotechnology products in cancer therapy: a colloquium. Cancer Res 48(1):223-5, Jan-Feb, 1/1988. PMID: 3275492.
175. Black CDV, Atcher RW, Barbet J, Brechbiel MW, Holton III OD, Hines JJ, Gansow OA, Weinstein JN. Selective ablation of B Lymphocytes in vivo by an alpha emitter, 212bismuth, chelated to a monocloncal antibody. J Antibody, Immunoconjugtes and Radiopharmaceuticals 1:43-53, 1988.
176. Barbet J, Black CDV, Holton III OD, Weinstein JN. Specific toxicity to activated T and B lymphocytes of a ricin A immunotoxin directed against the class I MHC antigen H-2 K. J Antibody, Immunoconjugates and Radiopharmaceuticals 1:169-80, 1988.
177. Holton OD, Black CD, Parker RJ, Covell DG, Barbet J, Sieber SM, Talley MJ, Weinstein JN. Biodistribution of monoclonal IgG1, F(ab')2, and Fab' in mice after intravenous injection. Comparison between anti-B cell (anti-Lyb8.2) and irrelevant (MOPC-21) antibodies. J Immunol 139(9):3041-9, 11/1987. PMID: 3499463.
178. Keenan AM, Weinstein JN, Carrasquillo JA, Bunn PA, Reynolds JC, Foon KA, Smarte NC, Ghosh B, Fejka RM, Larson SM. Immunolymphoscintigraphy and the dose dependence of 111In-labeled T101 monoclonal antibody in patients with cutaneous T-cell lymphoma. Cancer Res 47(22):6093-9, 11/1987. PMID: 3499222.
179. Mulshine JL, Keenan AM, Carrasquillo JA, Walsh T, Linnoila RI, Holton OD, Harwell J, Larson SM, Bunn PA, Weinstein JN. Immunolymphoscintigraphy of pulmonary and mediastinal lymph nodes in dogs: a new approach to lung cancer imaging. Cancer Res 47(13):3572-6, 7/1987. PMID: 3472655.
180. Eger RR, Covell DG, Carrasquillo JA, Abrams PG, Foon KA, Reynolds JC, Schroff RW, Morgan AC, Larson SM, Weinstein JN. Kinetic model for the biodistribution of an 111In-labeled monoclonal antibody in humans. Cancer Res 47(12):3328-36, 6/1987. PMID: 3581071.
181. Quill H, Carlson L, Fox BS, Weinstein JN, Schwartz RH. Optimization of antigen presentation to T cell hybridomas by purified Ia molecules in planar membranes. Ia molecule polymorphism determines the antigenic fine specificity of the response to cytochrome c peptides. J Immunol Methods 98(1):29-41, 4/1987. PMID: 2435810.
182. Parker RJ, Keenan AM, Dower SK, Steller MA, Holton OD, Sieber SM, Weinstein JN. Targeting of murine radiolabeled monoclonal antibodies in the lymphatics. Cancer Res 47(8):2073-6, 4/1987. PMID: 3828997.
183. Keenan AM, Weinstein JN, Mulshine JL, Carrasquillo JA, Bunn PA, Reynolds JC, Larson SM. Immunolymphoscintigraphy in patients with lymphoma after subcutaneous injection of indium-111-labeled T101 monoclonal antibody. J Nucl Med 28(1):42-6, 1/1987. PMID: 3794811.
184. Weinstein JN, Eger RR, Covell DG, Black CD, Mulshine J, Carrasquillo JA, Larson SM, Keenan AM. The pharmacology of monoclonal antibodies. Ann N Y Acad Sci 507:199-210, 1987. PMID: 3327413.
185. Lotze MT, Carrasquillo JA, Weinstein JN, Bryant GJ, Perentesis P, Reynolds JC, Matis LA, Eger RR, Keenan AM, Hellström I. Monoclonal antibody imaging of human melanoma. Radioimmunodetection by subcutaneous or systemic injection. Ann Surg 204(3):223-35, 9/1986. PMID: 3753057.
186. Covell DG, Barbet J, Holton OD, Black CD, Parker RJ, Weinstein JN. Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice. Cancer Res 46(8):3969-78, 8/1986. PMID: 3731067.
187. Weinstein JN, Lehmann TR, Hejna W, McNeill T, Spratt K. Chemonucleolysis versus open discectomy. A ten-year follow-up study. Clin Orthop Relat Res(206):50-5, 5/1986. PMID: 3708992.
188. Steller MA, Parker RJ, Covell DG, Holton OD, Keenan AM, Sieber SM, Weinstein JN. Optimization of monoclonal antibody delivery via the lymphatics: the dose dependence. Cancer Res 46(4 Pt 1):1830-4, 4/1986. PMID: 3948166.
189. Weinstein JN, Blumenthal R, Klausner RD. Carboxyfluorescein leakage assay for lipoprotein-liposome interaction. Methods Enzymol 128:657-68, Nov-Dec, 1986. PMID: 3724529.
190. Covell DG, Barbet J, Holton III OD, Black CVD, Keenan AM, Sieber SM, Weinstein JN. Global and local factors in the pharmacology of monoclonal antibodies. American Statistical Society Symposium, 1986.
191. Weinstein JN, Holton OD, Black CD, Keenan AM, Covell DG, Spaulding GF, Barbet J, Steller MA, Sieber SM, Talley MJ. Regional delivery of monoclonal antitumor antibodies: detection and possible treatment of lymph node metastases. Prog Clin Biol Res 212:169-81, Nov-Dec, 1986. PMID: 3714728.
192. Klausner RD, Blumenthal R, Innerarity T, Weinstein JN. The interaction of apolipoprotein A-I with small unilamellar vesicles of L-alpha-dipalmitoylphosphatidylcholine. J Biol Chem 260(25):13719-27, Nov-Dec, 11/1985. PMID: 3932344.
193. Covell DG, Steller MA, Parker RJ, Weinstein JN. Delivery of monoclonal antibodies through the lymphatics. Computer Applications in Medical Care 10:884-8, 1985.
194. Weinstein JN, Parker RJ, Holton OD, Keenan AM, Covell DG, Black CD, Sieber SM. Lymphatic delivery of monoclonal antibodies: potential for detection and treatment of lymph node metastases. Cancer Invest 3(1):85-95, Nov-Dec, 1985. PMID: 3971201.
195. Weinstein JN. Liposomes as drug carriers in cancer therapy. Cancer Treat Rep 68(1):127-35, Nov-Dec, 1/1984. PMID: 6692424.
196. Weinstein JN, Steller MA, Covell DG, Holton OD, Keenan AM, Sieber SM, Parker RJ. Monoclonal antitumor antibodies in the lymphatics. Cancer Treat Rep 68(1):257-64, Nov-Dec, 1/1984. PMID: 6692428.
197. Weinstein JN, Leserman LD. Liposomes as drug carriers in cancer chemotherapy. Pharmacol Ther 24(2):207-33, Nov-Dec, 1984. PMID: 6379684.
198. Weinstein JN, Stellar MA, Covell DG, Dower SK, Segal DM, Keenan AM, Sieber SM, Parker RJ. Use of monoclonal antibodies for diagnosis and therapy of tumor metastases in lymph nodes. Affinity Chromatography and Biological Recognition:33-42, 1984.
199. Weinstein JN, Steller MA, Keenan AM, Covell DG, Key ME, Sieber SM, Oldham RK, Hwang KM, Parker RJ. Monoclonal antibodies in the lymphatics: selective delivery to lymph node metastases of a solid tumor. Science 222(4622):423-6, Jul-Sep, 10/1983. PMID: 6623082.
200. Klausner RD, Kempf C, Weinstein JN, Blumenthal R, Van Renswoude J. The folding of ovalbumin. Renaturation in vitro versus biosynthesis in vitro. Biochem J 212(3):801-10, Jul-Sep, 6/1983. PMID: 6882395.
201. Miller M, Weinstein JN, Wlodawer A. Preliminary x-ray analysis of single crystals of ovalbumin and plakalbumin. J Biol Chem 258(9):5864-6, Jul-Sep, 5/1983. PMID: 6853552.
202. Blumenthal R, Kempf C, Van Renswoude J, Weinstein JN, Klausner RD. Voltage-dependent orientation of membrane proteins. J Cell Biochem 22(1):55-67, Jul-Sep, 1983. PMID: 6321525.
203. Kumar N, Blumenthal R, Henkart M, Weinstein JN, Klausner RD. Aggregation and calcium-induced fusion of phosphatidylcholine vesicle-tubulin complexes. J Biol Chem 257(24):15137-44, Jul-Sep, 12/1982. PMID: 6897406.
204. Weinstein JN, Parker RJ, Keenan AM, Dower SK, Morse HC, Sieber SM. Monoclonal anitbodies in the lymphatics: toward the diagnosis and therapy of tumor metastases. Science 218(4579):1334-7, Jul-Sep, 12/1982. PMID: 7146917.
205. Klausner RD, Berman M, Blumenthal R, Weinstein JN, Caplan SR. Compartmental analysis of light-induced proton movement in reconstituted bacteriorhodopsin vesicles. Biochemistry 21(15):3643-50, Jul-Sep, 7/1982. PMID: 7115689.
206. Kempf C, Klausner RD, Weinstein JN, Van Renswoude J, Pincus M, Blumenthal R. Voltage-dependent trans-bilayer orientation of melittin. J Biol Chem 257(5):2469-76, Jul-Sep, 3/1982. PMID: 7061434.
207. Weinstein JN, Blumenthal R, van Renswoude J, Kempf C, Klausner RD. Charge clusters and the orientation of membrane proteins. J Membr Biol 66(3):203-12, Jul-Sep, 1982. PMID: 6808138.
208. Blumenthal R, Ralston E, Dragsten P, Leserman LD, Weinstein JN. Lipid vesicle-cell interactions: analysis of a model for transfer of contents from adsorbed vesicles to cells. Membr Biochem 4(4):283-303, Jul-Sep, 1982. PMID: 6897439.
209. Blumenthal R, Klausner RD, Weinstein JN. Voltage-dependent changes in a membrane protein: Studies with the asialoglycoprotein receptor. Biophysical Journal 37:122-4, 1982.
210. Weinstein JN, Klausner RD, Innerarity T, Ralston E, Blumenthal R. Phase transition release, a new approach to the interaction of proteins with lipid vesicles. Application to lipoproteins. Biochim Biophys Acta 647(2):270-84, Jul-Sep, 10/1981. PMID: 6895324.
211. Klausner RD, Kumar N, Weinstein JN, Blumenthal R, Flavin M. Interaction of tubulin with phospholipid vesicles. I. Association with vesicles at the phase transition. J Biol Chem 256(11):5879-85, 6/1981. PMID: 6894593.
212. Kumar N, Klausner RD, Weinstein JN, Blumenthal R, Flavin M. Interaction of tubulin with phospholipid vesicles. II. Physical changes of the protein. J Biol Chem 256(11):5886-9, 6/1981. PMID: 6894594.
213. Pitas RE, Innerarity TL, Weinstein JN, Mahley RW. Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis 1(3):177-85, May-Jun, 5/1981. PMID: 6895305.
214. Yatvin MB, Mühlensiepen H, Porschen W, Weinstein JN, Feinendegen LE. Selective delivery of liposome-associated cis-dichlorodiammineplatinum(II) by heat and its influence on tumor drug uptake and growth. Cancer Res 41(5):1602-7, 5/1981. PMID: 7194141.
215. Ralston E, Hjelmeland LM, Klausner RD, Weinstein JN, Blumental R. Carboxyfluorescein as a probe for liposome-cell interactions: Effect of impurities and purification of the dye. Biochem Biophys Acta 649:133-7, 1981.
216. Parker RJ, Sieber SM, Weinstein JN. Effect of liposome encapsulation of a fluorescent dye on its uptake by the lymphatics of the rat. Pharmacology 23(3):128-36, 1981. PMID: 7280007.
217. Weinstein JN. Liposomes as "targeted" drug carriers. A physical chemical perspective. Pure and Applied Chemistry 53:2241-54, 1981.
218. Leserman LD, Weinstein JN, Moore JJ, Terry WD. Specific interaction of myeloma tumor cells with hapten-bearing liposomes containing methotrexate and carboxyfluorescein. Cancer Res 40(12):4768-74, 12/1980. PMID: 7438109.
219. Leserman LD, Barbet J, Kourilsky F, Weinstein JN. Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A. Nature 288(5791):602-4, 12/1980. PMID: 7442804.
220. Guo LS, Hamilton RL, Goerke J, Weinstein JN, Havel RJ. Interaction of unilamellar liposomes with serum lipoproteins and apolipoproteins. J Lipid Res 21(8):993-1003, 11/1980. PMID: 6780646.
221. Blumenthal R, Klausner RD, Weinstein JN. Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes. Nature 288(5789):333-8, 11/1980. PMID: 6253830.
222. Klausner RD, Bridges K, Tsunoo H, Blumenthal R, Weinstein JN, Ashwell G. Reconstitution of the hepatic asialoglycoprotein receptor with phospholipid vesicles. Proc Natl Acad Sci U S A 77(9):5087-91, 9/1980. PMID: 6254057.
223. Leserman LD, Weinstein JN, Blumenthal R, Terry WD. Receptor-mediated endocytosis of antibody-opsonized liposomes by tumor cells. Proc Natl Acad Sci U S A 77(7):4089-93, 7/1980. PMID: 7001454.
224. Weinstein JN, Magin RL, Cysyk RL, Zaharko DS. Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate. Cancer Res 40(5):1388-95, 5/1980. PMID: 6892792.
225. Ralston E, Blumenthal R, Weinstein JN, Sharrow SO, Henkart P. Lysophosphatidylcholine in liposomal membranes: enhanced permeability but little effect on transfer of a water-soluble fluorescent marker into human lymphocytes. Biochim Biophys Acta 597(3):543-51, 4/1980. PMID: 7378402.
226. Van Renswoude AJ, Blumenthal R, Weinstein JN. Thin-layer chromatography with agarose gels. A quick, simple method for evaluating liposome size. Biochim Biophys Acta 595(1):151-6, 1980. PMID: 7349878.
227. Blumenthal R, Klausner RD, Weinstein JN, Bridges K, Tsunoo H, Ashwell G. Voltage-dependent translocation of hepatic binding protein. Ann N Y Acad Sci 358:368-9, 1980. PMID: 6938158.
228. Wlodawer A, Segrest JP, Chung BH, Chiovetti R, Weinstein JN. High-density lipoprotein recombinants: evidence for a bicycle tire micelle structure obtained by neutron scattering and electron microscopy. FEBS Lett 104(2):231-5, 8/1979. PMID: 225206.
229. Weinstein JN, Magin RL, Yatvin MB, Zaharko DS. Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors. Science 204(4389):188-91, 4/1979. PMID: 432641.
230. Leserman LD, Weinstein JN, Blumenthal R, Sharrow SO, Terry WD. Binding of antigen-bearing fluorescent liposomes to the murine myeloma tumor MOPC 315. J Immunol 122(2):585-91, 2/1979. PMID: 368242.
231. Dragsten PR, Henkart P, Blumental R, Weinstein JN, Schlessinger J. Lateral diffusion of surface immunoglobulin, Thy-I antigen, and a lipid probe in lymphocyte plasma membranes. Proceedings of the National Academy of Science 76:5163-7, 1979.
232. Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R. Design of liposomes for enhanced local release of drugs by hyperthermia. Science 202(4374):1290-3, 12/1978. PMID: 364652.
233. Weinstein JN, Blumenthal R, Sharrow SO, Henkart PA. Antibody-mediated targeting of liposomes. Binding to lymphocytes does not ensure incorporation of vesicle contents into the cells. Biochim Biophys Acta 509(2):272-88, 5/1978. PMID: 656414.
234. Pagano RE, Weinstein JN. Interactions of liposomes with mammalian cells. Annu Rev Biophys Bioeng 7:435-68, 1978. PMID: 352245.
235. Blumenthal R, Weinstein JN, Sharrow SO, Henkart P. Liposome--lymphocyte interaction: saturable sites for transfer and intracellular release of liposome contents. Proc Natl Acad Sci U S A 74(12):5603-7, 12/1977. PMID: 271988.
236. Weinstein JN, Yoshikami S, Henkart P, Blumenthal R, Hagins WA. Liposome-cell interaction: transfer and intracellular release of a trapped fluorescent marker. Science 195(4277):489-92, 2/1977. PMID: 835007.
237. Blumenthal R, Weinstein JN, Henkart P. Lipid model membrane studies on immune cytotoxic mechanisms. Adv Exp Med Biol 84:495-507, 1977. PMID: 302636.
238. Weinstein JN, Leitz FB. Electric Power from Differences in Salinity: The Dialytic Battery. Science 191(4227):557-559, 2/1976. PMID: 17792805.
239. Weinstein JN, Leitz FB. Piezodialysis: A comparison of theoretical treatments. Desalination 16:245-7, 1/1975.
240. Weinstein JN, Caplan SR. The definition of volume flow in the Kedem-Katchalsky description of membrane transport. J Phys Chem 77:2710-1, 1973.
241. Weinstein JN, Kalif D, Caplan SR. Transport properties of charge-mosaic membranes II. Experimental studies. Desalination 12:1-17, 1973.
242. Gardner C, Weinstein JN, Caplan SR. Transport properties of charge-mosaic membranes III. Piezodialysis. Desalination 12:19-33, 1973.
243. Weinstein JN, Bunow B, Caplan SR. Transport properties of charge-mosaic membranes I. Theoretical considerations. Desalination 11:341-77, 1972.
244. Weinstein JN, Caplan SR. Charge-mosaic membranes: dialytic separation of electrolytes from nonelectrolytes and amino acids. Science 169(942):296-8, 7/1970. PMID: 5450359.
245. Weinstein JN, Caplan SR. Charge-mosaic membranes: enhanced permeability and negative osmosis with a symmetrical salt. Science 161(836):70-2, 7/1968. PMID: 5655268.
Other Articles
1. Hastie T, Tibshirani R, Eisen M, Brown P, Ross D, Scherf U, Weinstein JN, Alizadeh A, Staudt L, Botstein D. A new class of clustering methods for expression arrays. Technical Report, Statistics Department, Stanford University, 2000.

Book Chapters
1. Ben-Dor A, Lipson D, Tsalenko A, Baumbusch L, Barrett MM, Weinstein JN, Reimers M, Boressen-Dale A-L, Yakhini Z. Framework for Identifying Common Aberrations in DNA Copy Number Data. In: RECOMB 2007. Ed(s) T. Speed, H. Huang. Springer Berlin: Heidelberg, 122-36, 2007.
2. Weinstein JN. Linking drugs and genes: Pharmacogenomics, pharmacoproteomics, bioinformatics, and the NCI-60. In: Oncogenomics: Molecular Approaches to Cancer. John Wiley & Sons: New Jersey, 117-37, 2004.
3. Viswanadhan VN, Ghose AK, Kiselyov A, Weinstein JN, Wendeloski JJ. Knowledge-based approaches for the design of small molecule libraries for drug discovery. In: Combinatorial library design and evaluation: Principles, software tools, and Applications in Drug Discovery. Ed(s) Ghose AK, Viswanadhan VN. Marcel-Dekker: New York, 8888, 2001.
4. Weinstein JN, Waltham M, Reinhold W, Lee JK, Smith LH, Andrews D, Tanabe L, Zhou Y, Myers TG, Buolamwini JK, Scherf U. The current revolution in cancer drug discovery: Genomics, proteomics, and bioinformatics. In: Fighting against Cancer: Progress and New Hopes, 21-36, 2000.
5. Casciari J, Sato H, Durum SK, Fiege J, Weinstein JN. Reference databases of cytokine structure and function. In: Chemotherapy and Biological Response Modifiers Annual 16. Elsevier: Amsterdam, 315-46, 1996.
6. Casciari J, Sato H, Durum, SK, Fiege J, Weinstein JN. Tabular lexicon of cytokine structure and function. In: Cancer Chemotherapy and Biotherapy: Principles and Practice. Ed(s) Chabner BA, Longo D. Lippincott-Raven: Philadelphia, 787-810, 1996.
7. Chabner BA, Weinstein JN, Paull KD, Grever MR. Cell line-based screening for new anticancer drugs. In: Cancer Treatment an Update. Ed(s) Banzet P, Holland JF, Khayat D, Weil M. Springer-Verlag France: Paris, 10-6, 1994.
8. Weinstein JN. Neural networks and predictive statistics in drug discovery. In: Handbook for the International Forum on Advances in Screening Technology and Data Management, 79-83, 1994.
9. Weinstein JN, Bunow, B. COMBO: New concepts and methods for designing and analyzing experiments on combination therapy. In: Combination Therapies: Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases. Ed(s) Goldstein AL, Garaci E. Plenum Press: New York, 29-38, 1992.
10. Weinstein JN, Fujimore K. Antibody-mediated drug delivery. In: Protein Design and the Development of New Therapeutics and Vaccines. Ed(s) Jooke JB, Poste G. Plenum Press: New York, 359-70, 1990.
11. Weinstein JN, Fujimori K. The pharmacokinetics of monoclonal antibodies and derived peptides. In: Preclinical Evaluation of Peptides and Recombinant Proteins. Ed(s) Sundwall A. Skogs Grafiska AB: Stockholm, 35-41, 1990.
12. Weinstein JN, Fujimori K. Predictive Pharmacology of monoclonal antibodies. In: Cancer Therapy: New Trends. Ed(s) Bannasch P. Springer-Verlag: New York, 197-9, 1989.
13. Weinstein JN. Immunolymphoscintigraphy and other regional applications of monoclonal antibodies. In: Antibodies in Radiodiagnosis and Therapy. Ed(s) Zalutsky MR. CRC Press: Boca Raton, FL, 153-67, 1988.
14. Weinstein JN, Black CDV, Holton III OD, Covell DG, Parker RJ, Mulshine JL, Lotze MT, Carrasquillo J, Eger RR, Lewis A, Larson Sm, Keenan AM. Delivery of monoclonal antibodies to lymph nodes via the lymphatics. In: The Pharmacology and Toxicology of Proteins. Ed(s) Winkelhake JL, Holceberg JS. Alar R. Liss: New York, 75-89, 1987.
15. Weinstein JN. Liposomes in the diagnosis and treatment of cancer. In: Liposomes. Ed(s) Ostro M. Marcel Dekker: New York, 277-338, 1987.
16. Weinstein JN, Covell DG, Barbet J, Eger RR, Holton III OD, Talley MJ, Parker RJ, black CDV. The pharmacology of monoclonal antibodies. In: Membrane-mediated Cytotoxicity. Ed(s) Bonavida B, Collier RJ. Alan R. Liss: New York, 279-89, 1987.
17. Weinstein JN, Blumenthal R, Klausner RD. Carboxyfluorescein leakage assay for lipoprotein-liposome interaction. In: Methods in Enzymol. 128, A. Ed(s) Segrest JP, Albers JJ. Academic Press: London, 657-68, 1986.
18. Weinstein JN, Leserman LD. Liposomes as drug carriers in cancer chemotherapy. In: The International Encyclopedia of Pharmacology and Therapeutics: Membrane Transport of Anti-neoplastic Agents. 118. Ed(s) Goldman ID. Pergamon Press: New York, 169-94, 1986.
19. Weinstein JN, Black CDV, Barbet J, Eger RR, Parker RJ, Holton III OD, Mulshine JL, Keenan AM, Larson SM, Carrasquillo JA, Sieber SM, Covell DG. Selected issues in the pharmacology of monoclonal antibodies. In: Site-specific Drug Delivery: Cell Biology, Medicinal and Pharmaceutical Aspects. Ed(s) Tomlinson E, Davis SS. John Wiley: New York, 81-91, 1986.
20. Weinstein JN, Black CDV, Keenan AM, Holton III OD, Larson SM, Sieber SM, Covell DG, Carrasquillo J, Barbet J, Parker RJ. Use of monoclonal antibodies for detection of lymph node metastases. In: Monoclonal Antibodies in Cancer Therapy. Ed(s) Reisfeld RA, Sell S. Alan R. Liss: New York, 473-88, 1986.
21. Weinstein JN, Holton OD, Black CDV, Keenan AM, Covell DG, Spaulding GF, Barbet J, Steller MA, Sieber SM, Talley MJ, Parker RJ. Monoclonal Antitumor antibodies in the lumphatics. In: 1985 Year Book of Cancer. Ed(s) Hickey RC, Sunders GF. Year Book Medical Publishers: Chicago, 264-6, 1985.
22. Weinstein JN, Keenan AM, Holton III OD, Covell DG, Sieber SM, Black CDV, Barbet J, Parker RJ. Use of monoclonal antibodies to detect metastases of solid tumors in lumph nodes. In: Monoclonal Antibodies and Breast Cancer. Ed(s) Ceriani RL. Martinus Nijhof: Boston, 218-32, 1985.
23. Weinstein JN, Ralston E, Leserman LD, Klausner RD, Dragsten P, Blumenthal R. Self-quenching of carboxyfluorescein Fluorescence: Uses in studying lioposome stability and liposome-cell interaction. In: Liposome Technology. 3. Ed(s) Gregoriadis G. CRC Press: Boca Raton, FL, 183-204, 1984.
24. Blumenthal R, Kempf C, Renswoude JV, Weinstein JN, Klausner RD. Voltage-dependent orientation of membrane proteins. In: Protein Transport and Secretion. Ed(s) Oxender DL. Alan R. Liss: New York, 1-13, 1984.
25. Weinstein JN, Leserman LD, Henkart PA, Blumental R. Antibody-mediated targeting of liposomes. In: Targeting of Drugs. Ed(s) Gregoriadis G, Senior J, Trouet A. Plenum: New York, 185-202, 1982.
26. Magin RL, Weinstein JN. Delivery of drugs in temperature-sensitive liposomes. In: Targeting of Drugs. Ed(s) Gregoriadis G, Senior J, Trouet A. Plenum: New York, 203-21, 1982.
27. Leserman LD, Weinstein JN. Receptor mediated binding and endocytosis of drug-containing liposomes by tumor cells. In: Liposomes and Immunobiology. Elsevier: Amsterdam, 241-51, 1980.
28. Magin RL, Weinstein JN. Selective delivery of drugs in "temperature-sensitive" liposomes. In: Liposomes and Immunobiology. Elsevier: Amsterdam, 315-25, 1980.
29. Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R. Use of hyperthermia to promote selective local release of drugs from liposomes. In: Proceedings of the Conference on Clinical Prospects for Hypoxic Cell Sensitizers and Hyperthermia. Madison Printing and Publishing Company: Wisconsin, 105-12, 1978.

Last updated: 1/24/2013