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Jonathan M. Kurie, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 432
Houston, TX 77030
Room Number: FC9.3030
Phone: (713) 792-6363
Fax: (713) 792-1220

Education & Training

Degree-Granting Education

1983 East Carolina University, Greenville, NC, MD, Medicine
1979 University of North Carolina, Chapel Hill, NC, BA, Chemistry

Postgraduate Training

7/1988-6/1992 Medical Oncology Fellow, Memorial Sloan-Kettering Cancer Center, New York, NY, Ethan Dmitrovsky, M.D.
7/1986-6/1988 Biotechnology Fellow, Laboratory of Genetics, National Institutes of Health, National Cancer Institute, Bethesda, MD, Michael Potter, M.D.
7/1984-6/1986 Resident, Medical College of Georgia, Augusta, GA
7/1983-6/1984 Intern, Medical College of Georgia, Augusta, GA

Selected Publications

Peer-Reviewed Original Research Articles
1. Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM. Distinct biological roles for the notch ligands jagged-1 and jagged-2. J Biol Chem 284(26), 6/2009. e-Pub 4/2009. PMID: 19398556.
2. Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G, Kurie JM. Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS ONE 4(4). e-Pub 4/2009. PMCID: PMC2671160.
3. Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ. Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model. Am J Respir Cell Mol Biol 40(4):443-53, 4/2009. e-Pub 10/2008. PMCID: PMC2660561.
4. Sun H, Chung WC, Ryu SH, Ju Z, Tran HT, Kim E, Kurie JM, Koo JS. Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis. Cancer Prev Res (Phila Pa) 1(5):316-28, 10/2008. PMID: 19138976.
5. Johnson EM, Price RE, Kurie JM, Rivera BS, Cody DD. A new method for respiratory gating during microcomputed tomography of lung in mice. J Am Assoc Lab Anim Sci 47(4):46-56, 7/2008. PMID: 18702451.
6. Bhutani M, Pathak AK, Fan YH, Liu DD, Lee JJ, Tang H, Kurie JM, Morice RC, Kim ES, Hong WK, Mao L. Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs. Cancer Prev Res (Phila Pa) 1(1):39-44, 6/2008. PMID: 19138934.
7. Yang Y, Wislez M, Fujimoto N, Prudkin L, Izzo JG, Uno F, Ji L, Hanna AE, Langley RR, Liu D, Johnson FM, Wistuba I, Kurie JM. A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras. Mol Cancer Ther 7(4):952-60, doi: 10.1158/1535-7163.MCT-07-2045, 4/2008. PMID: 18413809.
8. Zhang L, Lee JJ, Tang H, Fan YH, Xiao L, Ren H, Kurie J, Morice RC, Hong WK, Mao L. Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers. Cancer Prev Res (Phila Pa) 1(2). e-Pub 3/2008. PMID: 19138944.
9. Zhang J, Iwanaga K, Choi KC, Wislez M, Raso MG, Wei W, Wistuba II, Kurie JM. Intratumoral Epiregulin Is a Marker of Advanced Disease in Non-Small Cell Lung Cancer Patients and Confers Invasive Properties on EGFR-Mutant Cells. Cancer Prev Res (Phila Pa) 1(3):201-207, 10.1158/1940-620/.CAPR-08-0014, 2008. e-Pub 3/2008. PMID: 19138957.
10. Yang Y, Iwanaga K, Raso MG, Wislez M, Hanna AE, Wieder ED, Molldrem JJ, Wistuba II, Powis G, Demayo FJ, Kim CF, Kurie JM. Phosphatidylinositol 3-Kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse Models of Oncogenic K-ras-induced Lung Cancer. PLoS ONE 3(5):e2220, 2008. PMCID: PMC2376060.
11. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM. Pten Inactivation Accelerates Oncogenic K-ras-initiated Tumorigenesis in a Mouse Model of Lung Cancer. Cancer Res 68(4):1119-27, 2008. PMID: 18281487.
12. Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, Ibarguen H, Morice RC, Walsh G, Roth JA, Minna J, Ro JY, Broxson A, Hong WK, Lee JJ. Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. J Natl Cancer Inst 99(21):1603-12, 11/2007. e-Pub 10/2007. PMID: 17971525.
13. Choi K, Creighton CJ, Stivers D, Fujimoto N, Kurie JM. Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations. PLoS ONE 2(11):1-11, 11/2007. e-Pub 11/2007. PMCID: PMC2080626.
14. Zhong L, Roybal J, Chaerkady R, Zhang W, Choi K, Alvarez CA, Tran H, Creighton CJ, Yan S, Strieter RM, Pandey A, Kurie JM. Identification of Secreted Proteins that Mediate Cell-Cell Interactions in an In Vitro Model of the Lung Cancer Microenvironment. Cancer Res 68(17):7237-7245, 9/2007. PMCID: PMC2562343.
15. Gray J, Mao JT, Szabo E, Kelley M, Kurie J, Bepler G, Bepler G. Lung cancer chemoprevention: ACCP evidence-based clinical practice guidelines (2nd Edition). Chest 132(3 Suppl):56S-68S, 9/2007. PMID: 17873160.
16. Sethi G, Ahn KS, Xia D, Kurie JM, Aggarwal BB. Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products. J Immunol 179(3):1926-33, 8/2007. PMID: 17641059.
17. Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene 7(48):1-9, 5/2007. e-Pub 5/2007. PMID: 17486075.
18. Xia D, Srinivas H, Ahn YH, Sethi G, Sheng X, Yung WK, Xia Q, Chiao PJ, Kim H, Brown PH, Wistuba II, Aggarwal BB, Kurie JM. Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NFkappaB-dependent pathway. J Biol Chem 282(6):3507-19, 2/2007. e-Pub 12/2006. PMID: 17158870.
19. Zhang J, Kalyankrishna S, Wislez M, Thilaganathan N, Saigal B, Wei W, Ma L, Wistuba II, Johnson FM, Kurie JM. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol 170(1):366-76, 1/2007. PMCID: PMC1762707.
20. Khatlani TS, Wislez M, Sun M, Srinivas H, Iwanaga K, Ma L, Hanna AE, Liu D, Girard L, Kim YH, Pollack JR, Minna JD, Wistuba II, Kurie JM. C-Jun N-terminal Kinase is activated in non-smal-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells. Oncogene 26(18)(18):2658-66, 10/2006. e-Pub 10/2006. PMID: 17057737.
21. Srinivas H, Xia D, Moore NL, Uray IP, Kim H, Ma L, Weigel NL, Brown PH, Kurie JM. Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha. Biochem J 395(3):653-62, 5/2006. PMCID: PMC1462695.
22. Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, Mao L, Wistuba I, Strieter RM, Kurie JM. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res 66(8):4198-207, 4/2006. PMID: 16618742.
23. Fujimoto N, Wislez M, Zhang J, Iwanaga K, Dackor J, Hanna AE, Kalyankrishna S, Cody DD, Price RE, Sato M, Shay JW, Minna JD, Peyton M, Tang X, Massarelli E, Herbst R, Threadgill DW, Wistuba II, Kurie JM. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res 65(24):11478-85, 12/2005. PMID: 16357156.
24. Mann KK, Padovani AM, Guo Q, Colosimo AL, Lee HY, Kurie JM, Miller WH. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. J Clin Invest 115(10):2924-33, 10/2005. e-Pub 9/2005. PMCID: PMC1224295.
25. Cody DD, Nelson CL, Bradley WM, Wislez M, Juroske D, Price RE, Zhou X, Bekele BN, Kurie JM. Murine lung tumor measurement using respiratory-gated micro-computed tomography. Invest Radiol 40(5):263-9, 5/2005. PMID: 15829823.
26. Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba II, Kurie JM. Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res 65(8):3226-35, 4/2005. PMID: 15833854.
27. Han JY, Liu DD, Lee JJ, Kurie J, Lotan R, Hong WK, Lee HY. 9-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers. Clin Cancer Res 11(6):2305-11, 3/2005. PMID: 15788681.
28. Srinivas H, Juroske DM, Kalyankrishna S, Cody DD, Price RE, Xu XC, Narayanan R, Weigel NL, Kurie JM. c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha. Mol Cell Biol 25(3):1054-69, 2/2005. PMCID: PMC543999.
29. Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, Shigematsu H, Peyton M, Juroske D, Huang Y, Stuart Salmon J, Kim YH, Pollack JR, Yanagisawa K, Gazdar A, Minna JD, Kurie JM, Carbone DP. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res 65(1):226-35, 2005. PMID: 15665299.
30. Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, Pollack J, Peyton M, Zou Y, Kurie JM, Dimaio JM, Milchgrub S, Smith AL, Souza RF, Gilbey L, Zhang X, Gandia K, Vaughan MB, Wright WE, Gazdar AF, Shay JW, Minna JD. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 64(24):9027-34, 12/2004. PMID: 15604268.
31. Kurie JM. Role of protein kinase B-dependent signaling in lung tumorigenesis. Chest 125(5 Suppl):141S-4S, 5/2004. PMID: 15136468.
32. Komaki R, Lee JS, Milas L, Lee HK, Fossella FV, Herbst RS, Allen PK, Liao Z, Stevens CW, Lu C, Zinner RG, Papadimitrakopoulou VA, Kies MS, Blumenschein GR, Jr, Pisters KM, Glisson BS, Kurie J, Kaplan B, Garza VP, Mooring D, Tucker SL, Cox JD. Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial. Int J Radiat Oncol Biol Phys 58(5):1369-77, 4/2004. PMID: 15050312.
33. Lee HY, Suh YA, Kosmeder JW, Pezzuto JM, Hong WK, Kurie JM. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res 10(3):1074-9, 2/2004. PMID: 14871987.
34. Cavanaugh D, Johnson E, Price RE, Kurie J, Travis EL, Cody DD. In vivo respiratory-gated micro-CT imaging in small-animal oncology models. Mol Imaging 3(1):55-62, 2004. PMID: 15142412.

Last updated: 9/14/2009