Jun-ichi Abe, MD, PhD

Peer-Reviewed Articles

1. Chen, W, Zhang, P, Tran, TN, Xiao, Y, Li, S, Shah, VV, Cheng, H, Brannan, KW, Youker, K, Lai, L, Fang, L, Yang, Y, Le, NT, Abe, J, Chen, SH, Ma, Q, Chen, K, Song, Q, Cooke, J, Wang, G. A visual–omics foundation model to bridge histopathology with spatial transcriptomics. Nature Methods 22(7):1568-1582, 2025. e-Pub 2025. PMID: 40442373.
2. Dhar, SS, Brown, CA, Rizvi, A, Reed, L, Kotla, S, Zod, C, Abraham, J, Abe, J, Rajaram, V, Chen, K, Lee, MG. Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS. Cell Reports 44(5), 2025. e-Pub 2025. PMID: 40286267.
3. Koutroumpakis, E, Naser, M, Mohamed, AS, Eraj, SA, Jarre, A, Shiao, J, Kamal Jomaa, M, Perni, S, Phan, J, Morrison, WH, Frank, SJ, Gunn, GB, Garden, AS, Deswal, A, Abe, J, Rosenthal, D, Mouhayar, E, Fuller, C. Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors. Clinical and Translational Radiation Oncology 51, 2025. e-Pub 2025. PMID: 39867727.
4. Millar # MW, Najar # RA, Slavin + SA, + MS, Tahir I, Mahamed Z, Lin X, Abe J, Wright TW, Dean DA, Fazal F, Rahman A. MTOR maintains endothelial cell integrity to limit lung vascular injury. Journal of Biological Chemistry 300(12), 2024. e-Pub 2024. PMID: 39510184.
5. Rmilah AA, Adham A, Ikram-Ul H, Alzu'bi H, Nandan A, Jouni H, Hirashi S, Owen D, Deswal A, Lin SH, Abe J, Chao TC, Browne J, Leiner T, Laack N, Herrmann J. Novel risk score for predicting acute cardiovascular and cerebrovascular events after chest radiotherapy in patients with breast or lung cancer. European Journal of Preventive Cardiolology, 2024. e-Pub 2024. PMID: 39453776.
6. Nead KT, Kim T, Joo L, McDowell TL, Wong JW, Chan ICC, Brock E, Zhao J, Xu T, Tang C, Lee CL, Abe JI, Bolton KL, Liao Z, Scheet PA, Lin SH. Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes. Blood Advances 8(19):5215-5224, 2024. e-Pub 2024. PMID: 38830141.
7. Koutroumpakis E, Naser MA, Mohamed ASR, Eraj SA, Jarre A, Shiao JC, Kamal M, Perni S, Phan JP, Morrison WH, Frank SJ, Gunn GB, Garden AS, Deswal A, Abe JI, Rosenthal DI, Mouhayar E, Fuller CD. Detection of Alteration in Carotid Artery Volumetry Using Standard-of-care Computed Tomography Surveillance Scans Following Unilateral Radiation Therapy for Early-stage Tonsillar Squamous Cell Carcinoma Survivors: A Cross-Sectional Internally-Matched Carotid Isodose Analysis. medRxiv, 2024. e-Pub 2024.
8. Chau KM, Dominic A, Davis EL, Kotla S, Berrios ET, Fahim A, Arunesh A, Li S, Zhao D, Chen K, Davis AR, H Nguyen MT, Wang Y, Evans SE, Wang G, Cooke JP, Abe J, Huston DP, Le N. TNIK regulation of interferon signaling and endothelial cell response to virus infection. Front Cardiovasc Med, 2024. e-Pub 2024. PMID: 38264262.
9. Reyes-Gibby CC, Qdaisat A, Ferrarotto R, Fadol A, Bischof JJ, Coyne CJ, Lipe DN, Hanna EY, Shete S, Abe J, Yeung SJ. Cardiovascular events after cancer immunotherapy as oncologic emergencies: Analyses of 610 head and neck cancer patients treated with immune checkpoint inhibitors. Head & Neck 46(3):627-635, 2023. e-Pub 2023. PMID: 38151809.
10. Dhar SS, Brown C, Rizvi A, Reed L, Kotla S, Zod C, Abraham J, Abe J, Rajaram V, Chen K, Lee M. Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation. bioRxiv, 2023. e-Pub 2023. PMID: 37961118.
11. Savage H, Pareek S, Lee J, Ballarò R, Conterno Minussi D, Hayek K, Sadullozoda M, Lochmann BS, McQuade JL, LaVoy EC, Marmonti E, Patel H, Wang G, Imanishi M, Kotla S, Abe JI, Schadler K. Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation. Cancer Immunology Research, 2023. e-Pub 2023. PMID: 37307577.
12. Nguyen MTH, Imanishi M, Li S, Chau K, Banerjee P, Velatooru LR, Ko KA, Samanthapudi VSK, Gi YJ, Lee LL, Abe RJ, McBeath E, Deswal A, Lin SH, Palaskas NL, Dantzer R, Fujiwara K, Borchrdt MK, Turcios EB, Olmsted-Davis EA, Kotla S, Cooke JP, Wang G, Abe JI, Le NT. Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition. Front Cardiovasc Med 10:1187490, 2023. e-Pub 2023. PMID: 37711550.
13. Abe, J, Imanishi, M, Li, S, Zhang, A, Ko, KA, Samanthapudi, VS, Lee, LL, Bojorges, AP, Gi, YJ, Hobbs, BP, Deswal, A, Herrmann, J, Lin, SH, Chini, EN, Shen, YH, Schadler, KL, Nguyen, TM, Gupte, AA, Reyes-Gibby, CC, Yeung, SJ, Abe, RJ, Olmsted-Davis, EA, Krishnan, S, Dantzer, R, Palaskas, NL, Cooke, J, Pownall, HJ, Yoshimoto, M, Fujiwara, K, Hamilton, DJ, Burks, JK, Wang, G, Le, NT, Kotla, S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circulation research 133(1):25-44, 2023. e-Pub 2023. PMID: 37264926.
14. Gurshaney, S, Morales-Alvarez, A, Ezhakunnel, K, Manalo, A, Huynh, TH, Abe, J, Le, NT, Weiskopf, D, Sette, A, Lupu, DS, Gardell, SJ, Nguyen, H. Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection. Communications Biology 6(1), 2023. e-Pub 2023. PMID: 37029220.
15. Zhang P, Chen W, Ye L, Brannan KW, Le N, Abe J, Cooke JP, Wang G. A relay velocity model infers cell-dependent RNA velocity. Nat Biotechnol 42(1):99-108, 2023. e-Pub 2023. PMID: 37012448.
16. Imanishi, M, Cheng, H, Kotla, S, Deswal, A, Le, NT, Chini, EN, Ko, KA, Samanthapudi, VS, Lee, LL, Herrmann, J, Xu, X, Reyes-Gibby, CC, Yeung, SJ, Schadler, KL, Yusuf, SW, Liao, Z, Nurieva, R, Amir, ED, Burks, JK, Palaskas, NL, Cooke, J, Lin, SH, Kobayashi, M, Yoshimoto, M, Abe, J. Radiation therapy induces immunosenescence mediated by p90RSK. Frontiers in Cardiovascular Medicine 9, 2022. e-Pub 2022. PMID: 36426217.
17. Wang, Y, Abe, J, Chau, KM, Wang, Y, Vu, HT, Reddy Velatooru, L, Gulraiz, F, Imanishi, M, Samanthapudi, VS, Nguyen, MT, Ko, KA, Lee, LL, Thomas, TN, Olmsted-Davis, EA, Kotla, S, Fujiwara, K, Cooke, J, Zhao, D, Evans, S, Le, NT. MAGI1 inhibits interferon signaling to promote influenza A infection. Frontiers in Cardiovascular Medicine 9, 2022. e-Pub 2022. PMID: 36082118.
18. Ju, Z, Thomas, TN, Chiu, YJ, Yamanouchi, S, Yoshida, Y, Abe, J, Takahashi, A, Wang, J, Fujiwara, K, Hada, M. Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector. International journal of molecular sciences 23(11), 2022. e-Pub 2022. PMID: 35682810.
19. Wang, X, Palaskas, NL, Hobbs, BP, Abe, J, Nead, KT, Yusuf, SW, Hermann, J, Deswal, A, Lin, SH. The Impact of Radiation Dose to Heart Substructures on Major Coronary Events and Patient Survival after Chemoradiation Therapy for Esophageal Cancer. Cancers 14(5), 2022. e-Pub 2022. PMID: 35267613.
20. Cornwell, A, Palli, R, Singh, MV, Benoodt, L, Tyrell, A, Abe, J, Schifitto, G, Maggirwar, SB, Thakar, J. Molecular characterization of atherosclerosis in HIV positive persons. Scientific reports 11(1), 2021. e-Pub 2021. PMID: 33547350.
21. Kotla, S, Zhang, A, Imanishi, M, Ko, KA, Lin, SH, Gi, YJ, Moczygemba, M, Isgandarova, S, Schadler, KL, Chung, C, Milgrom, SA, Banchs, J, Yusuf, SW, Amaya, D, Guo, H, Thomas, TN, Shen, YH, Deswal, A, Herrmann, J, Kleinerman, ES, Entman, ML, Cooke, J, Schifitto, G, Maggirwar, SB, Fujiwara, E, Gupte, AA, Krishnan, S, Patel, ZS, Yoon, Y, Burks, JK, Fujiwara, K, Brookes, PS, Le, NT, Hamilton, DJ, Abe, J. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox Biology 47, 2021. e-Pub 2021. PMID: 34619528.
22. Kinoshita, D, Shishido, T, Takahashi, T, Yokoyama, M, Sugai, T, Watanabe, K, Tamura, H, Nishiyama, S, Takahashi, H, Arimoto, T, Miyamoto, T, Watanabe, T, Kishida, S, Kadomatsu, K, Abe, J, Takeishi, Y, Konta, T, Kubota, I, Watanabe, M. Growth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin. Scientific reports 10(1), 2020. e-Pub 2020. PMID: 32587339.
23. Abe, RJ, Savage, H, Imanishi, M, Banerjee, P, Kotla, S, Paez-Mayorga, J, Taunton, J, Fujiwara, K, Won, JH, Yusuf, SW, Palaskas, NL, Banchs, J, Lin, SH, Schadler, KL, Abe, J, Le, NT. p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway. Frontiers in Cardiovascular Medicine 7, 2020. e-Pub 2020. PMID: 33304925.
24. Moudgil, R, Samra, G, Ko, KA, Vu, HT, Thomas, TN, Luo, W, Chang, J, Reddy, AK, Fujiwara, K, Abe, J. Topoisomerase 2B Decrease Results in Diastolic Dysfunction via p53 and Akt. Frontiers in Cardiovascular Medicine 7, 2020. e-Pub 2020. PMID: 33330654.
25. Wang, X, Palaskas, NL, Yusuf, SW, Abe, J, Lopez-Mattei, J, Banchs, J, Gladish, G, Lee, PP, Liao, Z, Deswal, A, Lin, SH. Incidence and Onset of Severe Cardiac Events After Radiotherapy for Esophageal Cancer. Journal of Thoracic Oncology 15(10):1682-1690, 2020. e-Pub 2020. PMID: 32599073.
26. Fujiwara, E, Parker-Thornburg, J, Fujii, Y, Aryal, NK, Smith, CN, Hofmann, M, Abe, J, Fujiwara, K. Rapid evaluation of CRISPR guides and donors for engineering mice. Genes 11(6):1-25, 2020. e-Pub 2020. PMID: 32521708.
27. Luo, W, Wang, Y, Zhang, L, Ren, P, Zhang, C, Li, Y, Azares, AR, Zhang, M, Guo, J, Ghaghada, KB, Starosolski, ZA, Rajapakshe, K, Coarfa, C, Li, Y, Chen, R, Fujiwara, K, Abe, J, Coselli, JS, Milewicz, DM, Lemaire, SA, Shen, YH. Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture. Circulation 141(1):42-66, 2020. e-Pub 2020. PMID: 31887080.
28. Quintana-Quezada, RA, Bui, L, Moudgil, R, Palaskas, NL, Hassan, SA, Abe, J, Mouhayar, E, Yusuf, SW, Hernandez, A, Banchs, J. Speckle-tracking echocardiography in cardio-oncology and beyond. Texas Heart Institute Journal 47(2):96-107, 2020. e-Pub 2020. PMID: 32603473.
29. Kotla, S, Le, NT, Vu, HT, Ko, KA, Gi, YJ, Thomas, TN, Giancursio, CJ, Lusis, AJ, Cooke, J, Fujiwara, K, Abe, J. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. Metabolism: clinical and experimental 100, 2019. e-Pub 2019. PMID: 31476350.
30. Milgrom, SA, Varghese, B, Gladish, G, Choi, AD, Dong, W, Patel, ZS, Chung, C, Rao, A, Pinnix, CC, Gunther, J, Dabaja, BS, Lin, SH, Hoffman, K, Huff, JL, Slagowski, J, Abe, J, Iliescu, C, Banchs, J, Yusuf, SW, Lopez-Mattei, J. Coronary artery dose-volume parameters predict risk of calcification after radiation therapy. Journal of Cardiovascular Imaging 27(4):268-279, 2019. e-Pub 2019. PMID: 31614398.
31. Lin, L, Shi, C, Sun, Z, Le, NT, Abe, J, Hu, K. The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk. Journal of Biological Chemistry 294(25):9901-9910, 2019. e-Pub 2019. PMID: 31076505.
32. Abe, J, Ko, KA, Kotla, S, Wang, Y, Paez-Mayorga, J, Shin, IJ, Imanishi, M, Vu, HT, Tao, Y, Leiva Juarez, MM, Thomas, TN, Medina, JL, Won, JH, Fujii, Y, Giancursio, CJ, McBeath, E, Shin, J, Guzman-Rojas, L, Abe, RJ, Taunton, J, Mochizuki, N, Faubion, W, Cooke, JP, Fujiwara, K, Evans, S, Le, NT. MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight 4(7), 2019. e-Pub 2019. PMID: 30944250.
33. Takahashi, T, Shishido, T, Kinoshita, D, Watanabe, K, Toshima, T, Sugai, T, Narumi, T, Otaki, Y, Tamura, H, Nishiyama, S, Arimoto, T, Takahashi, H, Miyamoto, T, Watanabe, T, Woo, CH, Abe, J, Takeishi, Y, Kubota, I, Watanabe, M. Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response. JACC: Basic to Translational Science 4(2):234-247, 2019. e-Pub 2019. PMID: 31061925.
34. Singh, MV, Kotla, S, Le, NT, Ko, KA, Heo, K, Wang, Y, Fujii, Y, Thi Vu, H, Fujiwara, E, Thomas, TN, Gi, YJ, Tao, Y, Medina, JL, Taunton, J, Carson, N, Dogra, V, Doyley, MM, Tyrell, A, Lu, W, Qiu, X, Stirpe, NE, Gates, KJ, Hurley, C, Fujiwara, K, Maggirwar, SB, Schifitto, G, Abe, J. Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. Circulation 139(9):1199-1216, 2019. e-Pub 2019. PMID: 30586719.
35. Kotla, S, Vu, HT, Ko, KA, Wang, Y, Imanishi, M, Heo, K, Fujii, Y, Thomas, TN, Gi, YJ, Mazhar, H, Paez-Mayorga, J, Shin, JH, Tao, Y, Giancursio, CJ, Medina, JL, Taunton, J, Lusis, AJ, Cooke, J, Fujiwara, K, Le, NT, Abe, J. Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein. JCI Insight 4(9), 2019. e-Pub 2019. PMID: 31045573.
36. Ko, KA, Wang, Y, Kotla, S, Fujii, Y, Vu, HT, Venkatesulu, BP, Thomas, TN, Medina, JL, Gi, YJ, Hada, M, Grande-Allen, J, Patel, ZS, Milgrom, SA, Krishnan, S, Fujiwara, K, Abe, J. Developing a Reliable Mouse Model for Cancer Therapy-Induced Cardiovascular Toxicity in Cancer Patients and Survivors. Frontiers in Cardiovascular Medicine 5, 2018. e-Pub 2018. PMID: 29675417.
37. Vu, HT, Kotla, S, Ko, KA, Fujii, Y, Tao, Y, Medina, JL, Thomas, TN, Hada, M, Sood, AK, Singh, PK, Milgrom, SA, Krishnan, S, Fujiwara, K, Le, NT, Abe, J. Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation. Frontiers in Cardiovascular Medicine 5, 2018. e-Pub 2018. PMID: 29594152.
38. Lin, S, Lee, Y, Yu, G, Cheng, CJ, Zhou, X, Chu, K, Murshed, M, Le, NT, Baseler, L, Abe, J, Fujiwara, K, Decrombrugghe, B, Logothetis, CJ, Gallick, GE, Yu-Lee, LY, Maity, S, Lin, S. Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer. Developmental cell 41(5):467-480.e3, 2017. e-Pub 2017. PMID: 28586644.
39. Ko, KA, Fujiwara, K, Krishnan, S, Abe, J. En face preparation of mouse blood vessels. Journal of Visualized Experiments 2017(123), 2017. e-Pub 2017. PMID: 28570508.
40. Mao, Y, Luo, W, Zhang, L, Wu, W, Yuan, L, Xu, H, Song, J, Fujiwara, K, Abe, J, Lemaire, SA, Wang, XL, Shen, YH. STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity. Arteriosclerosis, thrombosis, and vascular biology 37(5):920-929, 2017. e-Pub 2017. PMID: 28302626.
41. Knight, WE, Chen, S, Zhang, Y, Oikawa, M, Wu, M, Zhou, Q, Miller, CL, Cai, Y, Mickelsen, D, Moravec, CS, Small, EM, Abe, J, Yan, C. PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. Proceedings of the National Academy of Sciences of the United States of America 113(45):E7116-E7125, 2016. e-Pub 2016. PMID: 27791092.
42. Abe J, Kotla S, Lee J, Ko KA, Chen W, Kumar Samanthapudi VS, Hoang O, Mejia GF, Li S, Schadler KL, Rivera LA, Imanishi M, Tavares Samperio KC, Kim JH, Ostos-Mendoza KC, Mariscal-Reyes KN, Deswal A, Cooke JP, Fujiwara K, Palaskas NL, Koutroumpakis E, Gi YJ, Pathania R, Morrell C, Lorenzi PL, Tan L, Mahmud I, Hanssen NM, Yvan-Charvet L, Chini EN, Herrmann J, Vasquez HG, Shen YH, Martin JF, Xu H, Seeley EH, Burks JK, Brookes PS, Wang G, Le N, Abe J. Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation. Circulation Research.

Review Articles

1. Donisan, T, Balanescu, DV, Abe, J, Lerman, A, Iliescu, C, Herrmann, J. Vascular Toxicities of Cancer Therapies. Arteriosclerosis, thrombosis, and vascular biology 46(2):e319867, 2026. e-Pub 2026. PMID: 41376595.
2. López Moreno, SF, Lenz, SA, Casso-Chapa, B, Paniagua Bojorges, A, Kim, JH, Palaskas, NL, Nead, KT, Samanthapudi, VS, Mejia, G, Hoang, ON, Lee, J, Lin, SH, Herrmann, J, Wang, G, Yusuf, SW, Iliescu, C, Beinart, N, Manisty, C, Ushio-Fukai, M, Fukai, T, Ameri, P, Nurieva, R, Hildebrandt, MA, Schadler, KL, Koutroumpakis, E, Kotla, S, Le, NT, Abe, J. SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk. Antioxidants 14(12), 2025. e-Pub 2025. PMID: 41462587.
3. Abe, J, Chau, KM, Mojiri, A, Wang, G, Oikawa, M, Samanthapudi, VS, Osborn, AM, Ostos-Mendoza, KC, Mariscal-Reyes, KN, Mathur, T, Jain, A, Herrmann, J, Yusuf, SW, Krishnan, S, Deswal, A, Lin, SH, Kotla, S, Cooke, J, Le, NT. Impacts of Radiation on Metabolism and Vascular Cell Senescence. Antioxidants and Redox Signaling 43(1-3):92-114, 2025. e-Pub 2025. PMID: 40233257.
4. Casso-Chapa, B, Vazquez González, NA, Le, NT, Palaskas, NL, Nead, KT, Eutsey, LP, Samanthapudi, VS, Osborn, AM, Lee, J, Mejia, G, Hoang, ON, Lin, SH, Deswal, A, Herrmann, J, Wang, G, Kirkland, J, Krishnan, S, Wehrens, XH, Chini, EN, Yusuf, SW, Iliescu, C, Jain, A, Burks, JK, Seeley, EH, Lorenzi, PL, Chau, KM, Ostos-Mendoza, KC, Grumbach, IM, Brookes, PS, Hanssen, NM, de Winther, M, Yvan-Charvet, L, Kotla, S, Schadler, KL, Abe, J. Reevaluating Anti-Inflammatory Therapy. Arteriosclerosis, thrombosis, and vascular biology 45(3):372-385, 2025. e-Pub 2025. PMID: 39817327.
5. Abe JI, Allen BG, Beyer AM, Lewandowski D, Mapuskar KA, Subramanian V, Tamplin MR, Grumbach IM. Radiation-Induced Macrovessel/Microvessel Disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(12):2407-2415, 2024. e-Pub 2024. PMID: 39445428.
6. Abe J. A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease. Curr Atheroscler Rep, 2024. e-Pub 2024.
7. Abe J, # AJ, # DC, Padilla # AV, Bojorges # AP, Kotla S, Ko KA, K Samanthapudi VS, Chau K, H Nguyen MT, Wen J, Hernandez Gonzalez SL, Rodgers SP, Olmsted-Davis EA, Hamilton DJ, Reyes-Gibby C, Yeung SJ, Cooke JP, Herrmann J, Chini EN, Xu X, Yusuf SW, Yoshimoto M, Lorenzi PL, Hobbs B, Krishnan S, Koutroumpakis E, Palaskas NL, Wang G, Deswal A, Lin SH, Abe J, # NL. Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights. Frontiers in Cardiovascular Medicine, 2023. e-Pub 2023. PMID: 37781317.
8. Banerjee, P, Rosales, JE, Chau, KM, Nguyen, MT, Kotla, S, Lin, SH, Deswal, A, Dantzer, R, Olmsted-Davis, EA, Nguyen, H, Wang, G, Cooke, J, Abe, J, Le, NT. Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors. Frontiers in Cardiovascular Medicine 10, 2023. e-Pub 2023. PMID: 37332576.
9. Koutroumpakis, E, Agrawal, N, Palaskas, NL, Abe, J, Iliescu, C, Yusuf, SW, Deswal, A. Myocardial Dysfunction in Patients with Cancer. Heart Failure Clinics 18(3):361-374, 2022. e-Pub 2022. PMID: 35718412.
10. Banerjee, P, Olmsted-Davis, EA, Deswal, A, Nguyen, MT, Koutroumpakis, E, Palaskas, NL, Lin, SH, Kotla, S, Reyes-Gibby, CC, Yeung, SJ, Yusuf, SW, Yoshimoto, M, Kobayashi, M, Yu, B, Schadler, KL, Herrmann, J, Cooke, J, Jain, A, Chini, EN, Le, NT, Abe, J. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications. Journal of Cardiovascular Aging 2(3), 2022. e-Pub 2022. PMID: 35801078.
11. Koutroumpakis, E, Deswal, A, Yusuf, SW, Abe, J, Nead, KT, Potter, A, Liao, Z, Lin, SH, Palaskas, NL. Radiation-Induced Cardiovascular Disease. Current oncology reports 24(5):543-553, 2022. e-Pub 2022. PMID: 35192118.
12. Abe, RJ, Abe, J, Nguyen, MT, Olmsted-Davis, EA, Mamun, A, Banerjee, P, Cooke, J, Fang, L, Pownall, HJ, Le, NT. Free Cholesterol Bioavailability and Atherosclerosis. Current atherosclerosis reports 24(5):323-336, 2022. e-Pub 2022. PMID: 35332444.
13. Shobayo, F, Bajwa, M, Koutroumpakis, E, Hassan, SA, Palaskas, NL, Iliescu, C, Abe, J, Mouhayar, E, Karimzad, K, Thompson, KA, Deswal, A, Yusuf, SW. Acute coronary syndrome in patients with cancer. Expert Review of Cardiovascular Therapy 20(4):275-290, 2022. e-Pub 2022. PMID: 35412407.
14. Dominic, A, Hamilton, DJ, Abe, J. Mitochondria and chronic effects of cancer therapeutics. Journal of Thrombosis and Thrombolysis 51(4):884-889, 2021. e-Pub 2021. PMID: 33079380.
15. Banerjee, P, Kotla, S, Reddy Velatooru, L, Abe, RJ, Davis, EA, Cooke, J, Schadler, KL, Deswal, A, Herrmann, J, Lin, SH, Abe, J, Le, NT. Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer. Frontiers in Cardiovascular Medicine 8, 2021. e-Pub 2021. PMID: 34746270.
16. Koutroumpakis, E, Palaskas, NL, Lin, SH, Abe, J, Liao, Z, Banchs, J, Deswal, A, Yusuf, SW. Modern Radiotherapy and Risk of Cardiotoxicity. Chemotherapy 65(3-4):65-76, 2020. e-Pub 2020. PMID: 33049738.
17. Abe, J, Yusuf, SW, Deswal, A, Herrmann, J. Cardio-Oncology. Frontiers in Cardiovascular Medicine 7, 2020. e-Pub 2020. PMID: 33324688.
18. Dominic, A, Banerjee, P, Hamilton, DJ, Le, NT, Abe, J. Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis. Redox Biology 37, 2020. e-Pub 2020. PMID: 32863187.
19. Mahadeo, KM, Bajwa, R, Abdel-Azim, H, Lehmann, L, Duncan, C, Zantek, N, Vittorio, J, Angelo, J, McArthur, J, Schadler, KL, Chan, S, Tewari, P, Khazal, SJ, Auletta, JJ, Choi, SW, Shoberu, B, Kalwak, K, Harden, A, Kebriaei, P, Abe, J, Li, S, Moffet, J, Abraham, S, Tambaro, FP, Kleinschmidt, K, Richardson, PG, Corbacioglu, S. Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome. The Lancet Haematology 7(1):e61-e72, 2020. e-Pub 2020. PMID: 31818728.
20. Venkatesulu, BP, Mahadevan, LS, Aliru, ML, Yang, X, Bodd, M, Singh, PK, Yusuf, SW, Abe, J, Krishnan, S. Radiation-Induced Endothelial Vascular Injury. JACC: Basic to Translational Science 3(4):563-572, 2018. e-Pub 2018. PMID: 30175280.
21. Sylvester, CB, Abe, J, Patel, ZS, Grande-Allen, KJ. Radiation-Induced Cardiovascular Disease. Frontiers in Cardiovascular Medicine 5, 2018. e-Pub 2018. PMID: 29445728.
22. Le, NT, Martin, JF, Fujiwara, K, Abe, J. Sub-cellular localization specific SUMOylation in the heart. Biochimica et Biophysica Acta - Molecular Basis of Disease 1863(8):2041-2055, 2017. e-Pub 2017. PMID: 28130202.
23. Le, NT, Sandhu, UG, Quintana-Quezada, RA, Hoang, NM, Fujiwara, K, Abe, J. Flow signaling and atherosclerosis. Cellular and Molecular Life Sciences 74(10):1835-1858, 2017. e-Pub 2017. PMID: 28039525.
24. Abe, J, Sandhu, UG, Hoang, NM, Thangam, M, Quintana-Quezada, RA, Fujiwara, K, Le, NT. Coordination of cellular localization-dependent effects of sumoylation in regulating cardiovascular and neurological diseases. Advances in experimental medicine and biology 963:337-358, 2017. e-Pub 2017. PMID: 28197922.
25. Heo, K, Berk, BC, Abe, J. Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events. Antioxidants and Redox Signaling 25(7):435-450, 2016. e-Pub 2016. PMID: 26714841.
26. Abe, J, Morrell, C. Pyroptosis as a Regulated Form of Necrosis. Circulation research 118(10):1457-1460, 2016. e-Pub 2016. PMID: 27174943.
27. Chang, E, Abe, J. Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism: clinical and experimental 65(5):623-633, 2016. e-Pub 2016. PMID: 27085771.

Other Articles

1. Abe, J, Martin, JF, Yeh, E The Future of Onco-Cardiology. Circulation research 119(8):896-899, 2016. PMID: 27688305.

Editorials

1. Fukai, T, Wang, G, Abe, J. Disturbed flow-induced reprogramming of endothelial cells and two-hit mechanism of atherogenesis. Cardiovascular Research 121(17):2616-2618, 2025. PMID: 41330354.
2. Ewer, MS, Yusuf, SW, Asmis, R, Abe, J. Editorial: Case reports in cardio-oncology: 2022. Frontiers in Cardiovascular Medicine 10, 2023. PMID: 37522080.
3. Le, NT, Olmsted-Davis, EA, Abe, J. Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?. Clinical Science 136(5):379-382, 2022. PMID: 35274135.
4. Shen, YH, Abe, J. Nrg1β as a Proangiogenesis Therapy. Arteriosclerosis, thrombosis, and vascular biology 41(8):2315-2317, 2021. PMID: 34162231.
5. Shen, YH, Abe, J. Enigma of Inflammasome Activation by Kinases. Arteriosclerosis, thrombosis, and vascular biology 39(8):1501-1503, 2019. PMID: 31339780.
6. Abe, J, Sood, AK, Martin, JF. Editorial: Cardio-Oncology: From Bench to Bedside. Frontiers in Cardiovascular Medicine 6, 2019. PMID: 31024931.
7. Le, NT, Abe, J. Regulation of Kir2.1 function under shear stress and cholesterol loading. Journal of the American Heart Association 7(5), 2018. PMID: 29502108.
8. Le, NT, Abe, J. MicroRNA 199a and the eNOS (Endothelial NO Synthase)/NO Pathway. Arteriosclerosis, thrombosis, and vascular biology 38(10):2278-2280, 2018. PMID: 30354226.
9. Abe, J. Multiple functions of protein inhibitor of activated STAT1 in regulating endothelial cell proliferation and inflammation. Arteriosclerosis, thrombosis, and vascular biology 36(9):1717-1719, 2016. PMID: 27559144.

Abstracts

1. Kotla S, Rivera LA, Samanthapudi V, Mejia G, Hoang O, Li S, Chen W, Lee J, Kim JH, Nead KT, Koutroumpakis E, Deswal A, Mahalingam R, Nimmakayalu M, Krishnan S, Wang G, Nhat-Tu LE, Abe J. PIDD1 and p90RSK Mediate Radiation-Induced Genomic Instability in Endothelial Cells: Implications for Cardiovascular Disease Prevention. SfRBM 2025, 2025.
2. Kotla S, Samanthapudi V, Mejia G, Hoang O, Rivera L, Kim JH, Li S, Reddy A, Chen W, Lee J, Kyung Ae KO, Deswal A, Burks J, Palaskas N, Hidebrandt M, Lin S, Wang G, Le N, Abe J, Osborn A. Targeting Aldehydedehydrogenase: A Novel Mechanism for Colchicine’s Protective Effects Against Radiation-Induced Senescence and Atherosclerosis. SfRBM, 2025. e-Pub 2025.
3. Abe J, Samanthapudi VSK, Lee J, Ko KA, Mejia O, Rivera LA, Samperio KCT, Yusuf SW, Lin SH, Deswal A, Palaskas NL, Koutroumpakis E, Le NT, Kotla S. The functional role of TOP2beta PARylation in myeloid cells senescence-associated secretory phenotype (SASP) and atherosclerosis induction following ionizing radiation. ESC Cardio-oncology 2025, 2025. e-Pub 2025.
4. Kotla S, Jonghae Lee VSKS, Ko KA, Hoang O, Mejia GF, Rivera LA, T Samperio KC, L Moreno SF, Assunto S, Rajneesh Pathania EGS, Deswal A, Palaskas NL, Koutroumpakis E, Le N, Abe J. The functional role of TOP2β PARylation in myeloid cells senescence-associated secretory phenotype (SASP) and atherosclerosis induction following ionizing. DoIM retreat, 2025. e-Pub 2025.
5. Lee J, Samanthapudi VK, Imanishi M, Rivera LA, Hoang O, Mejia GF, Tavares Samperio KC, Reddy AK, L Moreno SF, Assunto S, Sanchez EG, Deswal A, Palaskas NL, Nead KT, Pathania R, Lin SH, Abe J, Kotla S. Colchicine inhibits radiation-induced inflammation, senescence, and clonal hematopoiesis drivers. DoIM retreat, 2025. e-Pub 2025.
6. Rivera L, Ko KA, Osborn A, Hoang O, Lee J, Tavares K, Samanthapudi VK, Mejia G, Sanchez EG, Nimmakayalu M, Le N, Deswal A, Lin SH, Abe J, Kotla AS. Mitigating Radiation-Induced senescence-associated secretory phenotype (SASP) and Atherosclerosis with p90RSK Inhibition. DoIm retreat, 2025. e-Pub 2025.
7. Lee J, Chau KM, Kumar SV, Mojiri A, Nguyen MT, Li S, Lorenzi PL, Mahmud I, Tan L, Cooke JP, Wang G, Kotla S, Abe J, Le N. Metabolite and Gene Expression Changes in Hutchinson-Gilford progeria syndrome (HGPS) Endothelial Cells: Impact of Suox/Mocs1 deficiency on Glycolysis and Pentose Phosphate Pathway (PPP). DoIM retreat, 2025. e-Pub 2025.
8. Kotla S, Lee J, Ko KA, Chen W, Samanthapudi VK, Hoang O, Mejia GF, Li S, Rivera LA, T Samperio KC, L Moreno SF, Assunto S, Sanchez EG, Pathania R, Wang G, Le N, Abe J. Disturbed Flow Downregulates LATS1/2, Driving Endothelial Senescence-Associated Stemness (SAS) and Thromboatherosclerotic Plaque Formation. DoIM retreat Cyrus award finalist (Dr. Kotla), 2025. e-Pub 2025.
9. Imanishi M, Li S, Ko KA, Chau KM, Zuo Y, Heo K, Rivera LA, Hoang O, Mejia GF, T Samperio KC, L Moreno SF, Assunto S, Sanchez EG, Schadler KL, Pathania R, Cheng J, Wang G, Le N, Kotla S, Abe J. Role of TERF2IP SUMOylation in Endothelial Cell Senescence and Atherogenesis Induced by Disturbed Flow and Telomere DNA damage. DoIM retreat, 2025. e-Pub 2025.
10. Kotla S, Ko KA, Lee J, Abigail O, Chen W, Samanthapudi VK, Pathania R, Mejia G, Hoang O, Ostos Mendoza KC, Mariscal Reyes KN, Chau KM, Burks J, Schadler K, Wang G, Chini EN, Martin JF, Le NT, Abe J. Disturbed Flow (d-flow)-induced Endothelial Senescence-Associated Stemness (SAS): Unveiling the Impact of CD38 and LATS1/2 Depletion on Atherothrombosis Development. American Heart Association Scientific Sessions, 2024. e-Pub 2024.
11. Kotla S, K Samanthapudi VS, Osborn AM, Lee J, Hoang O, Mejia GF, Ostos Mendoza KC, Schadler K, Chau K, NHAT TU T LE, Martin JF, Abe J. Telomeric Repeat-Binding Factor 2 Interacting Protein (TERF2IP) S205 Phosphorylation Orchestrates LATS1/2 Degradation under Disturbed Flow Conditions. American Heart Association Scientific Sessions, 2024. e-Pub 2024.
12. Kotla S, Lee J, Osborn AM, Pathania R, Chen W, K Samanthapudi VS, Mejia G, Hoang O, Ko KA, Ostos Mendoza KC, Chau K, NHAT TU T LE, Schadler K, Burks JK, Seeley EH, Lorenzi P, Brookes PS, Martin JF, Wang G, Chini EN, Abe J. CD38 Activation by Disturbed Flow (d-flow) Promotes Endothelial Cell (EC) Senescence-Associated Stemness (SAS) through Glutaminolysis Enhanced by Pyruvate Dehydrogenase (PDH) Inhibition, Leading to Atherothrombosis. American Heart Association Scientific Sessions, 2024. e-Pub 2024.
13. Chau K, Kotla S, K Samanthapudi VS, Lee J, Osborn A, Hoang O, Mejia G, Abe J, Le NT. Enhanced Mevalonate Pathway Through Laminar Flow-Induced DDIAS/ACLY Complex Supports Antioxidant Pathways and Angiogenesis Post-Hindlimb Ischemia. American Heart Association Scientific Sessions, 2024. e-Pub 2024.
14. Kotla S, Ko KA, Lee J, Samanthapudi VK, Abigail O, Mejia G, Ostos Mendoza KC, Mariscal Reyes KN, Hoang O, Chau KM, Schadler K, Martin JF, Le N, Abe J. LATS1/2 DEPLETION INDUCES CD38 EXPRESSION UNDER DISTURBED FLOW: A DUAL RESPONSE OF PROLIFARATION AND SENESCENCE CONTRIBUTING TO ATHEROTHROMBOSIS. The 6th Annual Gulf Coast Vascular Research Consortium, 2024. e-Pub 2024.
15. Lee J, Ko KA, Abigail O, Ostos Mendoza KC, Mariscal Reyes KN, Mejia G, Samanthapudi VK, Hoang O, Deswal A, Palaskas NL, Schadler K, Chau KM, Le N, Kotla S, Abe J. Immunocheckpoint inhibitor specifically accelerates coronary atherosclerosis not aorta. The 6th Annual Gulf Coast Vascular Research Consortium, 2024. e-Pub 2024.
16. Kotla S, Imanishi M, Chau KM, Li S, Samanthapudi VK, Abigail O, Lee J, Ostos Mendoza KC, Mariscal Reyes KN, Mejia G, Hoang O, Wang G, Le NT, Abe J. TERF2IP SUMOylation Drives Endothelial Senescence and Stemness. The 6th Annual Gulf Coast Vascular Research Consortium, 2024. e-Pub 2024.
17. Chaua KM, Kumar SV, MojiriaA, AbeaRJ, Lia S, Lorenzi PL, Mahmud I, Tan L, Kotla S, Abe J, Cookea JP, Wanga G, Le NT. The role of mitochondrial D-beta-hydroxybutyrate dehydrogenase (BDH1) in endothelial senescence. The 6th Annual Gulf Coast Vascular Research Consortium, 2024. e-Pub 2024.
18. Samanthapudi VK, Ko KA, Mejia G, Abigail O, Li S, Wang G, Ostos Mendoza KC, Mariscal Reyes KN, Hoang O, Lee J, Shadler K, Lin SH, Le N, Abe J, Kotla S. The unique role of cathepsin K (Ctsk) and solute carrier family 25 member 53 (Slc25a53) in Toll-like receptor 9 (TLR9)-induced endothelial senescence-associated secretory phenotype (SASP) after ionizing radiation (IR). The 6th Annual Gulf Coast Vascular Research Consortium, 2024. e-Pub 2024.
19. Abigail O, Reddy A, Samanthapudi VK, Ko KA, Mejia G, Ostos Mendoza KC, Mariscal Reyes KN, Hoang O, Lee J, Le N, Deswal A, Lin SH, Kotla S, Abe JI. Colchicine Mitigates Radiation-Induced senescence-associated secretory phenotype (SASP) and Atherosclerosis. The 6th Annual Gulf Coast Vascular Research Consortium, 2024. e-Pub 2024.
20. Lee J, Ko KA, Abigail O, Ostos Mendoza KC, Mariscal Reyes KN, Mejia G, Samanthapudi VK, Hoang O, Deswal A, Palaskas NL, Schadler K, Chau KM, Le N, Kotla S, Abe J. Immunocheckpoint inhibitor specifically accelerates coronary atherosclerosis not aorta. 2024 Vascular Scientific Sessions, 2024. e-Pub 2024.
21. Kotla S, Imanishi M, Chau KM, Li S, Samanthapudi VK, Abigail O, Lee J, Ostos Mendoza KC, Mariscal Reyes KN, Mejia G, Hoang O, Wang G, Le NT, Abe AJ. TERF2IP SUMOylation Drives Endothelial Senescence and Stemness. 2024 Vascular Scientific Sessions, 2024. e-Pub 2024.
22. Chaua KM, Kumarb SV, Mojiria A, Abe RJ, Lia S, Lorenzi PL, Mahmud I, Tan L, Kotlab S, Abe J, Cookea JP, Wang G, Le NT. The role of mitochondrial D-beta-hydroxybutyrate dehydrogenase (BDH1) in endothelial senescence. 2024 Vascular Scientific Sessions, 2024. e-Pub 2024.
23. Samanthapudi VK, Ko KA, Mejia G, Abigail O, Li S, Wang G, Ostos Mendoza KC, Mariscal Reyes KN, Hoang O, Lee J, Shadler K, Lin SH, Le N, Abe J, Kotla S. The unique role of cathepsin K (Ctsk) and solute carrier family 25 member 53 (Slc25a53) in Toll-like receptor 9 (TLR9)-induced endothelial senescence-associated secretory phenotype (SASP) after ionizing radiation (IR). 2024 Vascular Scientific Sessions, 2024. e-Pub 2024.
24. Abigail O, Reddy A, Samanthapudi VK, Ko KA, Mejia G, Ostos Mendoza KC, Mariscal Reyes KN, Hoang O, Lee J, Le N, Deswal A, Lin SH, Kotla S, Abe JI. Colchicine Mitigates Radiation-Induced senescence-associated secretory phenotype (SASP) and Atherosclerosis. 2024 Vascular Scientific Sessions, 2024. e-Pub 2024.
25. Kotla S, Ko KA, Lee J, Samanthapudi VK, Abigail O, Mejia G, Ostos Mendoza KC, Mariscal Reyes KN, Hoang O, Chau KM, Schadler K, Martin JF, Le N, Abe AJ. LATS1/2 DEPLETION INDUCES CD38 EXPRESSION UNDER DISTURBED FLOW: A DUAL RESPONSE OF PROLIFARATION AND SENESCENCE CONTRIBUTING TO ATHEROTHROMBOSIS. 2024 Vascular Scientific Sessions, 2024. e-Pub 2024.
26. Kotla S, Imanishi M, Li S, Ko KA, Samanthapudi VK, Hernandez Gonzalez SL, Perez KY, Rao A, Reddy KR, Agrawal A, Wang G, Le N, Abe J. Decoding ERK5 S496 Phosphorylation: Implications for Atherosclerosis and Senescence-Associated Stemness. 5th Annual Gulf Coast Vascular Research consortium meeting, 2024. e-Pub 2024.
27. Yoshimoto M, Cheng H, Syed A, Nishida C, Kobayashi M, Abe JI. Fetal-derived young B-1 cells prevent atherosclerosis progression in clonal hematopoiesis mouse model. The Journal of Immunology, 2024. e-Pub 2024.
28. Abe JI. Shared Mischief: How Aging Cells Conspire in Cancer and Vascular Disease. 2024 Chinese American Academy of Cardiology (CAAC) Research Symposium, 2024. e-Pub 2024.
29. Yoshimoto M, Cheng H, Syed A, Nishida C, Kobayashi M, Abe JI. Fetal-derived young B-1 cells prevent atherosclerosis progression in clonal hematopoiesis mouse model. 2024, Immunology 212 (1_Supplement), 2024. e-Pub 2024.
30. Abe J, Lee J, Pareek S, Ballarò R, Savage H, Patel H, Ko KA, Abe J, Schadler K. Exercise may be a Novel Strategy to Reduce Vascular Toxicity of Immune Checkpoint Inhibitors in a Mouse Melanoma Model. 2024 American Physiology Summit, 2024. e-Pub 2024.
31. Lee J, Pareek S, Ballarò R, Savage H, Patel H, Ko KA, Abe J, Schadler K. Exercise may be a Novel Strategy to Reduce Vascular Toxicity of Immune Checkpoint Inhibitors in a Mouse Melanoma Model. American Physiology Summit, 2024. e-Pub 2024.
32. Kotla S, Ko KA, Samanthapudi VK, Hernandez Gonzalez SL, Perez KY, Deswal A, Lin SH, Koutroumpakis E, Palaskas NL, Reyes-Gibby C, Yeung SCJ, Dantzer R, Morrell C, Krishnan S, Li S, Wang G, Chini EN, Martin JF, Le NT, Abe JI. Organized thrombus (OTh) formation and disturbed flow-induced senescence-associated stemness (SAS) in endothelial cells. AHA, 2023. e-Pub 2023.
33. Abe J, Qdaisat A, Reyes-Gibby CC, Abe J, Palaskas N, Shete SS, Yeung S. Cardiovascular Events as Oncologic Emergencies in Patients on Immune-Checkpoint Inhibitor Therapy. The Journal of Emergency Medicine 66(1), 2023. e-Pub 2023.
34. Qdaisat A, Reyes-Gibby CC, Abe J, Palaskas N, Shete SS, Yeung S. Cardiovascular Events as Oncologic Emergencies in Patients on Immune-Checkpoint Inhibitor Therapy. American Academy of Emergency Medicine, 2023. e-Pub 2023.
35. Ko KA, Kotla S, Samanthapudi VK, Hernandez Gonzalez SL, Perez KY, Rao A, Reddy KR, Agrawal A, Li S, Wang G, Martin JF, Le N, Abe J. Disturbed Flow Promotes Intraplaque Hemorrhage and Distal Pulmonary Thrombosis via LATS1/2 Expression Reduction and EC Apoptosis and Proliferation in Concert. 5th Annual Gulf Coast Vascular Research consortium meeting, 2023. e-Pub 2023.
36. Ko KA, Kotla S, Samanthapudi VK, Wen JJ, Hernandez Gonzalez SL, Deswal A, Lin SH, Koutroumpakis E, Palaskas NL, Reyes-Gibby C, Yeung SCJ, Dantzer R, Morrell C, Li S, Wang G, Martin JF, Le NT, Abe JI. LATS1/2 expression reduced by the pathological flow triggers intraplaque hemorrhage and distal pulmonary thrombosis by promoting EC apoptosis and proliferation in concert. ATVB, 2023. e-Pub 2023.
37. Kotla S, Ko KA, Samanthapudi VK, Wen JJ, Hernandez Gonzalez SL, Deswal A, Lin SH, Koutroumpakis E, Palaskas NL, Reyes-Gibby C, Yeung SCJ, Dantzer R, Morrell C, Li S, Wang G, Martin JF, Le NT, Abe JI. TERF2IP S205 phosphorylation instigates pathological flow-induced plaque erosion by reducing LATS1/2 expression. ATVB, 2023. e-Pub 2023.
38. Nguyen MTH, Imanishi M, Li S, Ko KA, Banerjee P, Velatooru LR, McBeath E, Fujiwara K, Kotla S, Chau K, Rei Abe, Borchardt MK, Yeh ET, Cooke JP, Wang G, Abe JI, Le NT. Checkpoint Kinase 1-Associated Senp2 S344 Phosphorylation Under Laminar Flow Attenuates Endothelial-Mesenchymal Transition and Atherogenesis. AHA, 2022.
39. Kotla S, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Deswal A, Hermann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen THM, Gupte AA, Reyes-gibby C, Yeung SCJ, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, Abe JI. ERK5 S496 Phosphorylation, but Not Erk5 Kinase Activation, Promotes Senescence-Associated Cell Growth (sacg) and Inflammation of Myeloid Cells and Atherosclerosis via Upregulating Sumoylation at a Novel Site (k518) on Nrf2 and Aryl Hydrocarbon Receptor. AHA, 2022.
40. Kotla S, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Gupte AA, Reyes-Gibby C, Yeung SCJ, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, Abe JI. ERK5 S496 Phosphorylation, but Not Erk5 Kinase Activation, Promotes Senescence-Associated Cell Growth (sacg) and Inflammation of Myeloid Cells and Atherosclerosis via Upregulating Sumoylation at a Novel Site (k518) on Nrf2 and Aryl Hydrocarbon Receptor. SfRBM, 2022.
41. Chau K, Imanishi M, Ko KA, Mcbeath E Fujiwara K, Jin Y, Heo K JCheng Thomas T, Schadle KL, Gupte AA, Shen YH, Lin S, Yeh ET, Zuo Y, Sharma A, SLi, Kotla Nguyen MT, Turcios E, Abe RJ, Zhang A, Hamilton D, Cooke JP, Wang G, AbeJI, Le NT. Terf2ip K240 Sumoylation Drives Endothelial Senescence and Atherogenesis via Activating Parp1. AHA, 2022. e-Pub 2022.
42. Wang Y, Vu HT, Velatooru LR, Wang Y, Thomas TN, Imanishi M, Kotla S, Le NT, Fujiwara k, Evans SE, Abe J. Influenza A virus infection increases MAGI1 expression in endothelial cells and its depletion inhibits virus replication through increased expression of MX1. ATVB, 2022.
43. Li S, Kotla S, Imanishi M, Ko KA, Samanthapudi VSK, Savage H, Schadler KL, Deswal A, Lin SH, Reyes-Gibby C, Yeung SCJ, Fujiwara K, Le NT, Wang G, Abe J. Differentially expressed genes mediated by ERK5 S496 phosphorylation in hypercholesterolemia-induced macrophage reprogramming. ATVB, 2022.
44. Kotla S, Imanishi M, Zhang A, Ko KA, Samanthapudi VSK, Savage H, Schadler KL, Abe RJ, Deswal A, Lin SH, Reyes-Gibby C, Yeung SCJ, Pownall HJ, Fujiwara K, Hamilton DJ, Li S, Wang G, Le NT, Abe J. ERK5 S496 phosphorylation, but not ERK5 kinase or transcriptional activity, is responsible for promoting macrophage inflammation and mitochondrial dysfunction via upregulating novel site of NRF2 K518 SUMOylation. ATVB, 2022.
45. Imanishi M, Cheng H, Kotla S, Lin SH, Deswal A, Ko KA, Samanthapudi VSK, Le NT, Fujiwara K, Liao Z, Palaskas N, Yusuf SW, Nurieva R, Reyes-Gibby C, Yeung SCJ, Amir ED, Burks JK, Kobayashi M, Yoshimoto M, Abe JI. Multiparameter mass cytometry reveals the unique response of naïve B cell CD27- subset with the increase of T-bet and CD38 expression after radiation therapy in thoracic cancer patients. ATVB, 2022. e-Pub 2022.
46. Kotla S, Imanishi M, Li S, Ko KA, Samanthapudi VSK, Savage H, Schadler KL, Shen YH, Deswal A, Lin SH, Reyes-Gibby C, Yeung SCJ, Pownall HJ, Fujiwara K, Burks JK, Le NT, Wang G, Abe JI. Qualitative single-cell assessment by imaging mass cytometry (IMC) analysis reveals senescence-associated stemness (SAS) induced by ERK5 S496 phosphorylation in atherosclerotic plaque. ATVB, 2022.
47. Kotla S, Imanishi M, Li S, Ko KA, Samanthapudi VSK, Savage H, Schadler KL, Shen YH, Deswal A, Lin SH, Reyes-Gibby C, Yeung SCJ, Pownall HJ, Fujiwara K, Burks JK, Le NT, Wang G, Abe JI. Qualitative single-cell assessment by imaging mass cytometry (IMC) analysis reveals senescence-associated stemness (SAS) induced by ERK5 S496 phosphorylation in atherosclerotic plaque. ATVB, 2022. e-Pub 2022.
48. Dominic A, Abe J, Le NT. A Surprising Role of TNIK in Regulating Endothelial Interferon Signaling and Activation. ATVB, 2021.
49. Velatooru LR, Abe RJ, Imanishi M, Gi YJ, Heo KS, Fujiwara K, Abe J, Le NT, Kotla S. Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells. SfRBM, 2021.
50. Das A, Varadarajan S, Yadav S, Fulton D, Kelley S, McMenamin M, Abe J, Kaplan JH, Ushio-Fukai M, Fukai T. ROS-dependent SUMOylation of Copper Chaperone Atox1 Orchestrates Endothelial Inflammatory and Angiogenic Signaling, Promoting Neovascularization Following Ischemic Injury. American Heart Association Scientific Sessions, 2021. e-Pub 2021.
51. Dominic A, Abe J, Le NT. A surprising role of TNIK in regulating endothelial interferon signaling and activation. George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Annual International Meeting, 2021.
52. Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Palaskas N, Schadler KL, Yusuf SW, Cooke JP, McBeath E, Guptae A, Krishnan S, Deswal A, Brookes PS, Fujiwara K, Burks JK, Le NT, Hamilton DJ, Abe J. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. NAVBO, 2021.
53. Ko KA, Imanishi M, Gi YJ, Kotla S, Fujiwara K, Abe J. Novel model of ionizing radition-induced mouse coronary atherosclerosis. ATVB, 2021.
54. Imanishi M, Ko KA, Wang Y, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Kotla S, Abe J. ATVB, 2021.
55. Imanishi M, Ko KA, Wang Y, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Kotla S, Abe JI. TERF2IP-K240R mutation suppresses D-flow- induced Endothelial cell senescence via suppressing DNA damage response. ATVB, 2021. e-Pub 2021.
56. Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Palaskas NL, Schadler KL, Milgrom SA, Banchs J, Yusuf SW, Amata D, Guo H, Thomas TN, Shen YH, Hermann J, Kleinerman ES, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Guptae A, Krishnan S, Patel ZS, Yoon Y, Brookes PS, Fujiwara K, Burks JK, Le NT, Hamilton DJ, Abe JI, Chung C. Monocyte and macrophage priming and cardiovascular injury from radiation exposure: potential role of PARP activation. NASA Human Research Program Invetigator's Workshop, 2021.
57. Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Palaskas NL, Schadler KL, Milgrom SA, Banchs J, Yusuf SW, Amata D, Guo H, Thomas TN, Shen YH, Herrmann J, Kleinerman ES, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Guptae A, Krishnan S, Patel ZS, Yoon Y, Brookes PS, Fujiwara K, Burks JK, Le NT, Hamilton DJ, Abe JI, Chung C. Monocyte and macrophage priming and cardiovascular injury from radiation exposure: potential role of PARP activation. NASA Human Research Program Invetigator’s Workshop, 2021. e-Pub 2021.
58. Kotla S, Zhang A, Ko KA, Imanishi M, Fujiwara K, Yoon Y, Brooks PS, Hamilton D, Abe J. Poly (ADP-ribose) polymerase (PARP) activation and mitochondrial hibernation induced by p90RSK-mediated ERK5 S496 phosphorylation promote mitochondrial ROS production in macrophage. IVBM, 2020.
59. Imanishi M, Ko KA, Kotla S, Thomas TN, Gi YJ, Wang Y, Fujiwara K, Savage H, Velatooru LR, Schadler KL, Shen YH, Le NT, Burks JK, Abe JI. Novel simultaneous multiplexed imaging with subcellular resolution by mass cytometry (Imaging mass cytometry: IMC) in atherosclerosis plaque (AS). ATVB, 2020.
60. Kotla S, Ko KA, Imanishi M, Banchs J, Palaskas NL, Yusuf SW, Fujiwara K, Le NT, Deswal A, Chung C, Lin SH, Abe JI. p90RSK-mediated ERK5 S496 phosphorylation and Poly (ADP-ribose) polymerase (PARP) activation promote monocyte/macrophage priming in mouse and cancer patients after radiation therapy (RT). ATVB, 2020.
61. Kotla S, Zhang A, Ko KA, Imanishi M, Fujiwara K, Yoon Y, Brookes PS, Hamilton D, Abe J. Poly (ADP-ribose) polymerase (PARP) activation and mitochondrial hibernation induced by p90RSK-mediated ERK5 S496 phosphorylation promote mitochondrial ROS production in macrophage. ATVB, 2020.
62. Kotla S, Zhang A, Ko KA, Imanishi M, Mazhar H, Thomas TN, Gi YJ, Vu HT, McBeath E, Lin SH, Palaskas NL, Banchs J, Kleinerman ES, Schadler KL, Fujiwara K, Le NT, Hamilton D, Krishnan S, Abe J. Cardiovascular toxic cancer treatments (CTCT) prime monocyte and macrophages to oxidative stress and accelerate atherogenesis. ATVB, 2019.
63. Imanishi M, Ko KA, Wang Y, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Kotla S, Abe J. Disturbed Flow-induced Endothelial Senescence, But Not Inflammation, Plays A Major Role In Plaque Formation Mediated By Telomeric Repeat Binding Factor 2-interacting Protein (TERF2IP) K240 SUMOylation. ATVB, 2019.
64. Vu HT, Heo KS, Imanishi M, Ko KA, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Abe J, Kotla S. The key role of endothelial SUMOylation in regulating sustained NADPH oxidase activation under disturbed flow: Involvement of feedback loop formed by FAK-SUMOylation. ATVB, 2019.
65. Abe J. Cardiovascular toxic cancer treatments (CTCT) prime monocyte and macrophages to oxidative stress and accelerate atherogenesis. 83rd Annual Scientific Meeting of the Japanese Circulation Society, Yokohama, Japan, 2019.
66. Abe J. Disturbed Flow Instigates Endothelial Senescence‒associated Secretory Phenotype (SASP) and Atherogenesis by Inducing Phosphorylation of Telomeric Repeat Binding Factor 2 (TRF2)‒interacting Protein (TERF2IP). 83rd Annual Scientific Meeting of the Japanese Circulation Society, Yokohama, Japan, 2019.
67. Kotla S, Singh MV, Le NT, Ko KA, Heo KS, Fujii Y, Vu HT, McBeath E, Thomas NT, Tao Y, Medina J, Stirpe NE, Lu W, Tyrell A, Gates KJ, Qui X, Fujiwara K, Maggirwar SJ, Schifitto G, Abe J. Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis. NAVBO, 2018.
68. Vu HT, Kotla S, Wang Y, Ko KA, Heo KS, Fujii Y, Thomas TN, Gi YJ, Medina J, Fujiwara K, Le NT, Abe J. Disturb flow induces p90RSK activation in endothelial cell, which increases TERF2IP phosphorylation causing endothelial cell dysfunction. ATVB, 2018.
69. Fujii Y, Vu HT, Kotla S, Ko KA, Wang Y, Thomas TN, Heo KS, Le NT, Fujiwara K, Abe J. Disturbed flow-induced TERF2IP K240 SUMOylation is critical for endothelial senescence but not inflammation. ATVB, 2018.
70. Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas TN, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Krishnan S, Fujiwara K, Le NT, Abe J. Ionizing radiation induces endothelial inflammation and apoptosis via p90RSK-mediated ERK5 S496 phosphorylation. ATVB, 2018.
71. Kotla S, Le NT, Singh MV, Ko KA, Heo KS, Fujii Y, Yu HT, McBeath E, Thomas TN, Tao Y, Medina J, Stirpe NE, Lu W, Tyrell A, Gates KJ, Qui X, Fujiwara K, Maggirwar SJ, Schifitto G, Abe J. Monocyte/macrophages are sensitized to secondary oxidative insult by cardiovascular toxic drugs via the p90RSK-ERK5 S496 phosphorylation pathway, aggrandizing atherosclerosis formation. ATVB, 2018.
72. Ko KA, Kotla S, Wang Y, Fujii Y, Vu HT, Venkatesulu BP, Thomas TN, Medina J, Gi Yj, Hada M, Grande-Allen J, Patel ZS, Milgrom SA, Kirshnan S, Fujiwara K, Abe J. Radiation induced atherosclerosis on mice. ATVB, 2018.
73. Kotla S, Le NT, Singh MV, Ko KA, Heo KS, Fujii Y, Vu HT, BcBeath E, Thomas TN, Tao Y, Medina J, Stirpe NE, Lu W, Tyrell A, Gates KJ, Qui X, Fujiwara K, Maggirwar SJ, Schifitto G, Abe J. Monocyte/macrophages are sensitized to secondary oxidative insult by cardiovascular toxic drugs via the p90RSK-ERK5 S496 phosphorylation pathway, aggrandizing atherosclerosis formation. Keystone Symposia, Santa Fe, NM, 2018.
74. Le NT, Singh MV, Ko KA, Heo KS, Fujii Y, Vu HT, McBeath E, Thomas TN, Tao Y, Medina J, Stirpe NE, Tyrell A, Gates KJ, Qui X, Fujiwara K, Maggirwar SJ, Schifitto G, Abe J. The Combination Antiretroviral Therapy (cart) Inhibits Efferocytosis-Related Gene Expression via Activating P90rsk and Accelerates Atherosclerosis. AHA, 2017. e-Pub 2017.
75. Le NT, Heo KS, Ko KA, Thomas T, Fujiwara K, Abe J. TERF2IP S205 phosphorylation mediates atherosclerosis via orchestratingendothelial cell senescence and inflammation. Aging and mechanisms of aging-related disease. Keystone symposium, Yokohama, Japan, 2017.
76. Le NT, Heo KS, Ko KA, Thomas T, Fujiwara K, Abe J. Post-translational modification of telomeric repeat-binding factor 2 (TERF2)-interacting protein (TERF2IP) mediates atherosclesis (AS) via orchestrating endothelial cell (EC) senescence (Sen) and inflammation. AHA, 2016.
77. Le NT, Won JH, Fujiwara K, Abe J. Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) regulates non-canonical large tumor suppressors (LATSs) kinase signaling and promotes endothelial (EC) apoptosis and inflammation. Gulf Coast Vascular Research Consortium, 2016.
78. Heo KS, Ko KA, Le NT, Fujiwara E, Thomas T, Medina J, Taunton J, Medina J, Taunton J, Fujiwara K, Abe J. The combination antiretroviral therapy (cART) inhibited efferocytosis-related gene expression via regulating p90RSK-ERK5 module and accelerated atherosclerosis development. Gulf Coast Vascular Research Consortium, 2016.
79. Le NT, Fujiwara k, Abe J. TRAF2 and NCK-interacting protein kinase (TNIK) as a molecular target of ponatinib- induced endothelial apoptosis and inflammation. Gulf Coast Vascular Research Consortium, 2016.
80. Abe J. Shear stress, post-translational modification, and atherosclerosis. 1st ASIA Conference on Pharmaceutical Sciences, 2016.
81. Shin I, Won JH, Ko KA, Fujiwara E, Shin JH, Thomas T, Taunton J, Hosokawa H, Mochizuki N, Yeh ET, Abe J, Fujiwara K, Le NT. The Membrane-associated guanylate kinase WW and PDZ Domain-containing Protein 1 (MAGI1) is required for disturbed flow-induced endothelial inflammation and atherosclerosis. 1st ASIA Conference on Pharmaceutical Sciences, 2016.
82. Abe J, Shin I, Ko KA, Fujiwara E, Shin JH, Thomas T, Fujiwara E, Taunton j, Medina J, Won JH, Fujiwara K, Le NT. Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) as a key pro-inflammatory molecule in disturbed flow-induced atherosclerosis formation. 11th International Symposium on BioMechanics in Vascular Biology and Cardiovascular Disease, 2016.
83. Shin I, Won JH, Ko KA, Fujiwara E, Shin JH, Thomas T, Taunton J, Hosokawa H, Mochizuki N, Yeh ET, Abe J, Fujiwara K, Le NT. The Membrane-associated guanylate kinase WW and PDZ Domain-containing Protein 1 (MAGI1) is required for disturbed flow-induced endothelial inflammation and atherosclerosis plaque formation. ATVB, 2016.
84. Le NT, Shin I, Ko KA, Thomas T, Medina J, Won JH, Fujiwara K, Abe J. Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) as a key pro-inflammatory molecule in promoting chronic inflammatory disease. Division of Internal Medicine, 2016.
85. Heo KS, Ko KA, Le NT, Fujiwara E, Thomas T, Medina J, Taunton J, Fujiwara K, Abe J. The combination antiretroviral therapy (cART) inhibited efferocytosis-related gene expression via regulating p90RSK-ERK5 module and accelerated atherosclerosis development. Division of Internal Medicine, 2016.
86. Le NT, Won JH, Fujiwara K, Abe J. TRAF2 and NCK-interacting protein kinase (TNIK) as a molecular target of ponatinib- induced endothelial apoptosis and inflammation. Division of Internal Medicine, 2016.
87. Shin I, Won JH, Ko KA, Fujiwara E, Shin JH, Thomas T, Taunton J, Mochizuki N, Yeh ET, Abe j, Fujiwara K, Le N. The membrane-associated guanylate kinase WW and PDZ domain-containing protein 1 (MAGI1) is required for disturbed flow-induced endothelial inflammation and atherosclerosis. Keystone Symposia, NF-kB and MAP kinase signaling in inflammation, 2016.

Book Chapters

1. Abe J, Sandhu UG, Hoang NM, Thangam M, Quintana-Quezada RA, Fujiwara K, Le NT. Coordination of cellular localization-dependent effects of SUMOylation in regulating cardiovascular and neurological diseases. In: SUMO Regulation of Cellular Processes, Second edition. Springer, 2017.
2. Le NT, Hoang NM, Abe J, Fujiwara K. MEK5/ERK5. In: Encyclopedia of Signaling Molecules, 2nd Edition. Springer, 2016.
3. Le NT, Yang J, Abe J. MEK5/ERK5. In: Encyclopedia of Signaling Molecules. Springer-ESM, 2011.
4. Abe J, Yang J. MEK5, 2010.
5. Abe J, Pan S, Krovic B, Fujiwara K. Shear stress-mediated signal transduction. In: Hemodynamics & Mechanobiology of Endothelium. World Scientific Publishing, 2010.
6. Berk BC, Surapistchat J, Yoshizumi M, Yan C, Hoefen R, Abe J. Atheroprotective mechanisms of fluid shear stress: Nitic oxidide independent inhibition of signal transduction mediated by inflammatory cytokine. In: Vascular endothelium Source and target of inflammatory Mediators. IOS Press, 115-125, 2001.
7. Abe J, Yan C, Surapisitchat J, Berk BC. Kinase Signaling in the Cardiovascular System. In: Heart Physiology and Pathophysiology. 4. Academic Press, 657-677, 2000.
8. Abe J, Berk BC. Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease. In: Antioxidant and Cardiovascular Disease. Kluwer Academic Publishers, 2000.

Books (edited and written)

1. Abe JI, Sood AK, James Martin. Cardio-Oncology: From Bench to Bedside. Frontiers in Cardiovascular Medicine,, 2019.

Web Publications

1. Abe J, kotla S, Ko KA, Hamilton DJ. CV Toxicity and Mitochondrial Dysfunction: Why Younger Hearts Are at Risk, 2020.