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Junjie Chen, PhD

Present Title & Affiliation

Primary Appointment

Professor and Chair, Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Junjie Chen is the professor and chair of the Department of Experimental Radiation Oncology as of July 1, 2009. Dr. Chen is an internationally recognized scientist who has made significant contributions to the field of genomic stability, especially in the area of DNA damage responsive pathways and cancer biology.

Research Interests

The overall goal of his laboratory is to understand the molecular mechanisms underlying genomic instability and tumorigenesis. The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair with cell cycle checkpoint controls. The integrity of the DNA damage response pathway is crucial for the prevention of neoplastic transformation, as suggested by the fact that many proteins involved in these pathways are tumor suppressors including p53, ATM, Chk2, BRCA1 and BRCA2. His group has discovered and studied many new components involved in DNA damage pathways. Recently, Dr. Chen’s group also ventured into other areas of genomic instability, including mitotic regulation, cellular senescence and aging. He demonstrated a mitotic checkpoint protein Chfr is a tumor suppressor, which controls proper mitotic progression via its regulation of several key mitotic kinases. His lab is also studying a protein deacetylase SIRT1 and its role in aging and tumorigenesis.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Experimental Radiation Oncology
Unit Number: 066
Houston, TX 77030
Room Number: Y3.6006
Phone: 713/792-4863
Fax: 713/794-5369
Email: jchen8@mdanderson.org

Education & Training

Degree-Granting Education

1993 University of Vermont, Burlington, VT, PHD, Cell and Molecular Biology
1989 Institute of Plant Physiology, Academia SINICA, Shanghai, China, Master's Program, Physiology
1988 Fudan University, Shanghai, China, BS, Genetics/Genetic Engineering

Postgraduate Training

1996-1999 Postdoctoral Fellow, Breast cancer susceptibility genes BRCA1, BRCA2 and control for DNA repair, Harvard Medical School, Boston, MA, Dr. David M. Livingston
1994-1996 Postdoctoral Fellow, Tumor Suppressor protein p53, the cell cycle regulatory protein p21 and control of DNA replication, Harvard Medical School, Boston, MA, Dr. Anindya Dutta
1989-1993 Predoctoral Researcher, Chromatin Structure and Regulation of the HSP26 Gene in the Yeast Saccharomyces cerevisiae, University of Vermont, Burlington, VT, Dr. David S. Pederson

Experience/Service

Academic Appointments

Professor, Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, 2006-2009
Associate Professor, Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, 2004-2006
Consultant (tenured), Department of Oncology, Mayo Clinic, Rochester, MN, 2003-2006
Assistant Professor, Molecular Pharmacology and Experimental therapeutics, Mayo Medical School, Rochester, MN, 2001-2003
Assistant Professor, Biochemistry and Molecular Medicine, Mayo Medical School, Mayo Foundation, Rochester, MN, 2000-2003
Senior Associate Consultant, Oncology, Mayo Clinic, Rochester, MN, 1999-2003

Selected Publications

Peer-Reviewed Original Research Articles

1. Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic Analysis of the Human Cyclin-dependent Kinase Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration. Mol Cell Proteomics 13(11):2986-3000, 11/2014. e-Pub 8/2014. PMID: 25096995.
2. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol 16(9):864-75, 9/2014. e-Pub 8/2014. PMCID: PMC4150825.
3. Cleaver JE, Brennan-Minnella AM, Swanson RA, Fong KW, Chen J, Chou KM, Chen YW, Revet I, Bezrookove V. Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proc Natl Acad Sci U S A 111(37):13487-92, 9/2014. e-Pub 8/2014. PMCID: PMC4169934.
4. Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol 206(7):877-94, 9/2014. PMCID: PMC4178966.
5. Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the fanconi anemia core complex. Cell Rep 7(6):1849-57, 6/2014. e-Pub 6/2014. PMID: 24910428.
6. Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J Cell Sci 127(Pt 9):2029-39, 5/2014. e-Pub 2/2014. PMCID: PMCPMC4004977.
7. Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J. Defining the protein-protein interaction network of the human Hippo pathway. Mol Cell Proteomics 13(1):119-31, 1/2014. e-Pub 10/14/2013. PMCID: PMC3879608.
8. Wang F, Cheng J, Liu D, Sun H, Zhao J, Wang J, Chen J, Su Y, Zou Z. P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium. Arch Biochem Biophys 542C:21-27, 1/2014. e-Pub 12/2013. PMID: 24315958.
9. Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z. Akt regulates TPP1 homodimerization and telomere protection. Aging Cell 12(6):1091-9, 12/2013. e-Pub 8/11/2013. PMID: 23862686.
10. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol 15(12):1486-94, 12/2013. e-Pub 11/2013. PMCID: PMCPMC3951854.
11. Wang J, Chen J, Gong Z. TopBP1 Controls BLM Protein Level to Maintain Genome Stability. Mol Cell 52(5):667-78, 12/2013. e-Pub 11/2013. PMCID: PMCPMC3880544.
12. Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol 203(1):149-64, 10/14/2013. PMCID: PMC3798253.
13. Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res 23(10):1215-28, 10/2013. e-Pub 9/3/2013. PMCID: PMC3790240.
14. Leung CC, Sun L, Gong Z, Burkat M, Edwards R, Assmus M, Chen J, Glover JN. Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure 21(8):1450-9, 8/2013. e-Pub 7/2013. PMCID: PMC3760280.
15. Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A 110(26):10640-5, 6/2013. e-Pub 6/2013. PMCID: PMC3696823.
16. Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. EMBO J 32(11):1584-97, 5/2013. e-Pub 4/2013. PMCID: PMC3671259.
17. Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem 288(16):11135-43, 4/2013. e-Pub 3/2013. PMCID: PMC3630874.
18. Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress. J Biol Chem 288(9):6342-50, 3/2013. e-Pub 1/2013. PMCID: PMC3585069.
19. Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 Maintain Genome Stability via Cooperative as Well as Unique Functions. Mol Cell 49(5):997-1009, 3/2013. e-Pub 1/2013. PMCID: PMC3595374.
20. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci 126(Pt 3):825-37, 2/2013. e-Pub 12/2012. PMCID: PMC3619811.
21. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem 288(5):3174-83, 2/2013. e-Pub 12/2012. PMCID: PMC3561539.
22. Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res 73(1):205-14, 1/2013. e-Pub 11/2012. PMCID: PMC3538077.
23. Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J 32(1):126-39, 1/2013. e-Pub 11/2012. PMCID: PMC3545304.
24. Ghosal G, Chen J. DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res 2(3):107-129, 2013. PMCID: PMC3779140.
25. Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev 26(24):2737-48, 12/15/2012. PMID: 23249736.
26. Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol 110(3):349-57, 12/2012. e-Pub 10/3/2012. PMID: 23054561.
27. Fei J, Chen J. KIAA1530 is recruited by cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem 287(42):35118-26, 10/12/2012. e-Pub 8/17/2012. PMCID: PMC3471710.
28. Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. PCNA-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem 287(41):34225-33, 10/5/2012. e-Pub 8/17/2012. PMCID: PMC3464530.
29. Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev 26(17):1959-71, 9/1/2012. PMCID: PMC3435498.
30. Yuan J, Ghosal G, Chen J. The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress. Mol Cell 47(3):410-21, 8/10/2012. e-Pub 6/14/2012. PMID: 22705370.
31. Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem 287(27):22919-26, 6/29/2012. e-Pub 4/25/2012. PMCID: PMC3391110.
32. Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A 109(12):4491-6, 3/20/2012. e-Pub 3/6/2012. PMCID: PMC3311328.
33. Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J. RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst) 11(2):131-8, 2/1/2012. e-Pub 10/28/2011. PMID: 22036607.
34. Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol 19(2):201-6, 2/2012. e-Pub 1/22/2012. PMID: 22266820.
35. Liu T, Wan L, Wu Y, Chen J, Huang J. hSWS1{middle dot}SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair. J Biol Chem 286(48):41758-66, 12/2011. e-Pub 9/2011. PMCID: PMC3308884.
36. Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol 18(12):1400-7, 12/2011. e-Pub 11/2011. PMID: 22101936.
37. Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS. Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses. J Biol Chem 286(25):22355-61, 6/24/2011. e-Pub 5/10/2011. PMCID: PMC3121383.
38. Gong Z, Chen J. E3 Ligase RFWD3 Participates in Replication Checkpoint Control. J Biol Chem 286(25):22308-13, 6/24/2011. e-Pub 4/18/2011. PMCID: PMC3121377.
39. Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET Nuclear Oncogene Associates with Microcephalin/MCPH1 and Regulates Chromosome Condensation. J Biol Chem 286(24):21393-400, 6/17/2011. e-Pub 4/22/2011. PMCID: PMC3122199.
40. Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep 12(6):574-80, 6/2011. e-Pub 4/28/2011. PMCID: PMC3128281.
41. Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 13(6):728-33, 6/2011. e-Pub 5/1/2011. PMID: 21532586.
42. Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev 25(9):959-71, 5/1/2011. PMCID: PMC3084029.
43. Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol 193(2):267-73, 4/18/2011. e-Pub 4/11/2011. PMCID: PMC3080258.
44. Yuan J, Chen J. The Role of the Human SWI5-MEI5 Complex in Homologous Recombination Repair. J Biol Chem 286(11):9888-93, 3/18/2011. e-Pub 1/20/2011. PMCID: PMC3059048.
45. Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem 286(6):4364-70, 2/11/2011. e-Pub 12/27/2010. PMCID: PMC3039387.
46. Leung CC, Gong Z, Chen J, Glover JN. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem 286(6):4292-301, 2/11/2011. e-Pub 12/2/2010. PMCID: PMC3039391.
47. Feng L, Wang J, Chen J. The Lys 63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem 285(40):30982-8, 10/1/2010. e-Pub 7/22/2010. PMCID: PMC2945589.
48. Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol 17(10):1255-9, 10/2010. e-Pub 9/26/2010. PMCID: PMC2950913.
49. Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair. Science 329(5992):693-6, 8/6/2010. e-Pub 7/29/2010. PMID: 20671156.
50. Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J. SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle 9(13). e-Pub 7/26/2010. PMID: 20581448.
51. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38(6):864-78, 6/25/2010. PMID: 20620956.
52. Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med 207(5):973-81, 5/10/2010. e-Pub 4/12/2010. PMCID: PMC2867275.
53. Wang J, Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem 285(15):11458-64, 4/9/2010. e-Pub 1/25/2010. PMCID: PMC2857024.
54. Park G, Gong Z, Chen J, Kim JE. Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J 29(3):213-23, 4/2010. PMID: 20431927.
55. Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell 37(6):854-64, 3/26/2010. PMID: 20347427.
56. Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res 38(5):1489-503, 3/2010. e-Pub 12/14/2009. PMCID: PMC2836575.
57. Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol 395(5):908-15, 2/5/2010. e-Pub 11/17/2009. PMCID: PMC2813331.
58. Gong Z, Kim JE, Leung CC, Glover JN, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 37(3):438-46, 2/12/2010. PMID: 20159562.
59. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest 120(2):545-58, 2/1/2010. e-Pub 1/11/2010. PMCID: PMC2810074.
60. Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem 285(2):1097-104, 1/8/2010. e-Pub 11/12/2009. PMCID: PMC2801237.
61. Kim JE, Lou Z, Chen J. Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle 8(22):3784-5, 11/15/2009. e-Pub 11/11/2009. PMID: 19855164.
62. Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem 284(46):31746-52, 11/13/2009. e-Pub 9/16/2009. PMCID: PMC2797245.
63. Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev 23(20):2394-9, 10/15/2009. e-Pub 9/30/2009. PMCID: PMC2764499.
64. Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest 119(9):2714-24, 9/2009. e-Pub 8/17/2009. PMCID: PMC2735912.
65. Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell 35(4):534-41, 8/28/2009. PMID: 19716796.
66. Sy SM, Huen MS, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem 284(32):21127-31, 8/7/2009. e-Pub 6/24/2009. PMCID: PMC2755835.
67. Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell 35(3):384-93, 8/14/2009. PMCID: PMC2756616.
68. Sy SM, Huen MS, Zhu Y, Chen J. PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization. J Biol Chem 284(27):18302-10, 7/3/2009. e-Pub 5/7/2009. PMCID: PMC2709360.
69. Maddika S, Sy SM, Chen J. Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem 284(19):12998-3003, 5/8/2009. e-Pub 3/25/2009. PMCID: PMC2676032.
70. Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol 11(5):592-603, 5/2009. e-Pub 4/26/2009. PMCID: PMC2743127.
71. Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A 106(17):7155-60, 4/28/2009. e-Pub 4/15/2009. PMCID: PMC2678481.
72. Maddika S, Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol 11(4):409-19, 4/2009. e-Pub 3/15/2009. PMCID: PMC2754075.
73. Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem 284(11):7284-93, 3/13/2009. e-Pub 1/5/2009. PMCID: PMC2652327.
74. Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev 23(6):719-28, 3/15/2009. e-Pub 3/4/2009. PMCID: PMC2661609.
75. Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Mol Cell Biol 29(3):849-860, 2/2009. e-Pub 11/17/2008. PMCID: PMC2630672.
76. Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol 11(2):204-10, 2/2009. e-Pub 12/21/2008. PMCID: PMC2712943.
77. Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem 283(46):31785-31790, 11/14/2008. e-Pub 9/17/2008. PMCID: PMC2581543.
78. Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol 28(22):6870-6, 11/2008. e-Pub 9/15/2008. PMCID: PMC2573299.
79. Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem 283(43):29586-92, 10/24/2008. e-Pub 8/21/2008. PMCID: PMC2570891.
80. Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol 28(19):6104-12, 10/2008. e-Pub 8/4/2008. PMCID: PMC2547017.
81. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol 10(9):1076-82, 9/2008. PMCID: PMC2882053.
82. Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A 105(32):11200-5, 8/12/2008. e-Pub 8/4/2008. PMCID: PMC2516250.
83. Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol 381(2):361-72, 8/29/2008. e-Pub 6/14/2008. PMCID: PMC2574983.
84. Wu L, Beito T, Chen J. Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (Larchmt) 27(4):313-8, 8/2008. PMID: 18707550.
85. Huang J, Chen J. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene 27(29):4056-64, 7/3/2008. e-Pub 3/10/2008. PMID: 18332868.
86. Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol 181(5):727-35, 6/2/2008. e-Pub 5/26/2008. PMCID: PMC2396806.
87. Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem 283(17):11073-7, 4/25/2008. e-Pub 3/3/2008. PMCID: PMC2431066.
88. Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 28(8):2825-39, 4/2008. e-Pub 2/19/2008. PMCID: PMC2293113.
89. Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 451(7178):583-6, 1/31/2008. PMID: 18235501.
90. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Mol Cell 28(6):1045-1057, 12/28/2007. PMCID: PMC2275782.
91. Kim H, Chen J. c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun 362(4):842-7, 11/3/2007. e-Pub 8/22/2007. PMCID: PMC2047600.
92. Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 282(48):35416-23, 11/30/2007. e-Pub 10/9/2007. PMCID: PMC2128040.
93. Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131(5):901-14, 11/30/2007. e-Pub 11/20/2007. PMCID: PMC2149842.
94. Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 6(9):1243-54, 9/2007. e-Pub 3/2007. PMID: 17376750.
95. Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol 14(8):710-5, 8/2007. e-Pub 7/22/2007. PMID: 17643122.
96. Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316(5828):1202-5, 5/25/2007. PMID: 17525342.
97. Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127(7):1361-73, 12/29/2006. PMCID: PMC1804291.
98. Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem 281(50):38472-7, 12/15/2006. e-Pub 10/16/2006. PMCID: PMC1853281.
99. Chini CC, Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 281(44):33276-33282, 11/3/2006. e-Pub 9/8/2006. PMID: 16963448.
100. Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314(5797):294-7, 10/13/2006. PMID: 17038621.
101. Lai M, Chen J. The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle 5(19):2275-80, 10/2006. e-Pub 10/1/2006. PMID: 16969134.
102. Wu X, Dong X, Liu W, Chen J. Characterization of CHEK2 mutations in prostate cancer. Hum Mutat 27(8):742-7, 8/2006. PMID: 16835864.
103. Yu X, Fu S, Lai M, Baer R, Chen J. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev 20(13):1721-6, 7/1/2006. PMCID: PMC1522068.
104. Chini CC, Wood J, Chen J. Chk1 is required to maintain claspin stability. Oncogene 25(30):4165-71, 7/13/2006. e-Pub 2/27/2006. PMID: 16501606.
105. Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440(7080):105-9, 3/2/2006. e-Pub 1/8/2006. PMID: 16400328.
106. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from Progressing to Chromosome breaks and Translocations. Mol Cell 21(2):201-214, 1/20/2006. PMID: 16427010.
107. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21(2):187-200, 1/20/2006. PMID: 16427009.
108. Lai M, Zimmerman ES, Planelles V, Chen J. Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol 79(24):15443-51, 12/2005. PMCID: PMC1315993.
109. Karnitz LM, Flatten KS, Wagner JM, Loegering D, Hackbarth JS, Arlander SJ, Vroman BT, Thomas MB, Baek YU, Hopkins KM, Lieberman HB, Chen J, Cliby WA, Kaufmann SH. Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol 68(6):1636-44, 12/2005. e-Pub 8/26/2005. PMID: 16126823.
110. Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol 25(24):10907-15, 12/2005. PMCID: PMC1316943.
111. Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol 25(22):10079-86, 11/2005. PMCID: PMC1280262.
112. Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol 12(7):589-93, 7/2005. e-Pub 6/19/2005. PMID: 15965487.
113. Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadińanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Genomic instability in laminopathy-based premature aging. Nat Med 11(7):780-785, 7/2005. e-Pub 6/26/2005. PMID: 15980864.
114. Ohashi A, Zdzienicka MZ, Chen J, Couch FJ. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem 280(15):14877-83, 4/15/2005. e-Pub 1/25/2005. PMID: 15671039.
115. Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ 12(4):326-334, 4/2005. PMID: 15650754.
116. Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet 37(4):401-6, 4/2005. e-Pub 3/27/2005. PMID: 15793587.
117. Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem 280(7):5733-9, 2/18/2005. e-Pub 11/15/2004. PMID: 15545273.
118. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem 279(45):46359-62, 11/5/2004. e-Pub 9/17/2004. PMID: 15377652.
119. Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24(21):9478-86, 11/2004. PMCID: PMC522253.
120. Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus 1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol 24(21):9286-9294, 11/2004. PMCID: PMC522272.
121. Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166(6):801-813, 9/13/2004. PMCID: PMC2172115.
122. Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure 12(7):1137-46, 7/2004. PMID: 15242590.
123. Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. J Cell Biol 165(4):459-64, 5/24/2004. PMCID: PMC2172356.
124. Ward IM, Minn K, Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem 279(11):9677-80, 3/12/2004. e-Pub 1/23/2004. PMID: 14742437.
125. Rodriguez M, Yu X, Chen J, Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem 278(52):52914-8, 12/26/2003. e-Pub 10/24/2003. PMID: 14578343.
126. Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science 302(5645):639-42, 10/24/2003. PMID: 14576433.
127. Wu X, Chen J. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J Biol Chem 278(38):36163-8, 9/19/2003. e-Pub 7/9/2003. PMID: 12855706.
128. Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem 278(32):30051-6, 8/8/2003. e-Pub 5/23/2003. PMID: 12766176.
129. Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 278(32):30057-62, 8/8/2003. e-Pub 5/24/2003. PMID: 12766152.
130. Yamane K, Chen J, Kinsella TJ. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res 63(12):3049-3053, 6/15/2003. PMID: 12810625.
131. Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 278(22):19579-82, 5/30/2003. e-Pub 4/15/2003. PMID: 12697768.
132. Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem 278(16):13599-602, 4/18/2003. e-Pub 2/27/2003. PMID: 12611903.
133. Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol 23(7):2556-63, 4/2003. PMCID: PMC150747.
134. Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421(6926):957-61, 2/27/2003. PMID: 12607004.
135. Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4(12):993-7, 12/2002. PMID: 12447390.
136. Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem 277(10):7849-56, 3/8/2002. e-Pub 12/18/2001. PMID: 11751867.
137. Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 22(2):555-66, 1/2002. PMCID: PMC139754.
138. Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 276(51):47759-62, 12/21/2001. e-Pub 10/22/2001. PMID: 11673449.
139. Ward IM, Wu X, Chen J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J Biol Chem 276(51):47755-47758, 12/21/2001. e-Pub 10/19/2001. PMID: 11668173.
140. Joukov V, Chen J, Fox EA, Green JB, Livingston DM. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A 98(21):12078-83, 10/9/2001. e-Pub 10/2/2001. PMCID: PMC59770.
141. Rappold I, Iwabuchi K, Date T, Chen J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol 153(3):613-20, 4/30/2001. PMCID: PMC2190566.
142. Wu X, Webster SR, Chen J. Characterization of tumor-associated Chk2 mutations. J Biol Chem 276(4):2971-4, 1/26/2001. e-Pub 10/26/2000. PMID: 11053450.
143. Chen J. ATR is involved in teh Phosphorlyation of BRCA1 following DNA damage. Cancer Res 60(18):5037-5039, 9/15/2000. PMID: 11016625.
144. Wu X, Petrini JH, Heine WF, Weaver DT, Livingston DM, Chen J. Independence of R/M/N focus formation and the presence of intact BRCA1. Science 289(5476):11-11a, 7/7/2000. PMID: 10928918.
145. Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic Analysis of BRCA1 function in a defined tumor cell line. Mol Cell 4(6):1093-1099, 12/1999. PMID: 10635334.
146. Chen JJ, Silver D, Cantor S, Livingston DM, Scully R. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res 59(7 Suppl):1752s-1756s, 4/1/1999. PMID: 10197592.
147. Wilson CA, Ramos L, Villaseńor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 21(2):236-240, 2/1999. PMID: 9988281.
148. Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2(3):317-28, 9/1998. PMID: 9774970.
149. Geraghty DS, Sucic HB, Chen J, Pederson DS. Evidence that partial unwrapping of DNA from nucleosomes facilitates the binding of heat shock factor following DNA replication in yeast. J Biol Chem 273(32):20463-72, 8/7/1998. PMID: 9685401.
150. Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol 18(5):2758-67, 5/1998. PMCID: PMC110655.
151. Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90(3):425-35, 8/8/1997. PMID: 9267023.
152. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88(2):265-75, 1/24/1997. PMID: 9008167.
153. Chen U, Chen S, Saha P, Dutta A. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A 93(21):11597-602, 10/15/1996. PMCID: PMC38103.
154. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 16(9):4673-82, 9/1996. PMCID: PMC231467.
155. Leiter LM, Chen J, Marathe T, Tanaka M, Dutta A. Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53. Oncogene 12(12):2661-8, 6/20/1996. PMID: 8700525.
156. Chen J, Peters R, Saha P, Lee P, Theodoras A, Pagano M, Wagner G, Dutta A. A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo. Nucleic Acids Res 24(9):1727-33, 5/1/1996. PMCID: PMC145832.
157. Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374(6520):386-8, 3/23/1995. PMID: 7885482.
158. Chen J, Ding M, Pederson DS. Binding of TFIID to the CYC1 TATA boxes in yeast occurs independently of upstream activating sequences. Proc Natl Acad Sci U S A 91(25):11909-13, 12/6/1994. PMCID: PMC45345.
159. Chen J, Pederson DS. A distal heat shock element promotes the rapid response to heat shock of the HSP26 gene in the yeast Saccharomyces cerevisiae. J Biol Chem 268(10):7442-8, 4/1993. PMID: 8463277.

Invited Articles

1. Huen MS, Chen J. When loose ends finally meet. Nat Struct Mol Biol 15(12):1241-1242, 12/2008. PMID: 19050718.
2. Wood JL, Chen J. DNA-damage checkpoints: location, location, location. Trends Cell Biol 18(10):451-455, 10/2008. e-Pub 8/27/2008. PMID: 18760607.
3. Kim H, Chen J. New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells 25(4):457-461, 6/30/2008. e-Pub 4/24/2008. PMID: 18443409.
4. Huen MS, Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Res 18(1):8-16, 1/2008. PMID: 18087291.
5. Kim JE, Minter-Dykhouse K, Chen J. Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses. Mol Carcinog 45(i6):403-408, 6/2006. PMID: 16691596.
6. Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint i cancer and aging: what have mice taught us? Curr Opin Cell Biol 17(6):583-589, 12/2005. e-Pub 10/13/2005. PMID: 16226453.
7. Chini CC, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst) 3(8-9):1033-1037, Aug-Sep, 8/2004. PMID: 15279790.
8. Ward I, Chen J. Early events in the DNA damage response. Curr Top Dev Biol 63:1-35, 2004. PMID: 15536012.
9. Lou Z, Chen J. Use of siRNA to study the function of MDC1 in DNA damage responses. Methods Mol Biol 281:179-187, 2004. PMID: 15220529.
10. Lou Z, Chen J. BRCA proteins and DNA damage checkpoints. Front Biosci 8:s718-721, 5/1/2003. PMID: 12700125.
Other Articles
1. Li X, Wang W, Chen J. From pathways to networks: Connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry. Proteomics. e-Pub 8/2014. PMID: 25137225.
2. Li N, Chen J. ADP-Ribosylation: Activation, Recognition, and Removal. Mol Cells 37(1):9-16, 1/2014. e-Pub 1/2014. PMCID: PMC3907000.
3. Ghosal G, Chen J. Alteration/deficiency in activation 3 (ADA3): Regulator of DNA repair and genome stability. Cell Cycle 11(24):4496, 12/15/2012. e-Pub 12/6/2012. PMID: 23222062.
4. Ting L, Jun H, Junjie C. RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair (Amst) 9(12):1241-8, 12/10/2010. PMID: 20971043.
5. Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: to be or not to be. FEBS Lett 584(17):3717-24, 9/10/2010. e-Pub 5/21/2010. PMID: 20493860.
6. Huen MS, Chen J. ATM Creates a veil of transcriptional silence. Cell 141(6):924-6, 6/11/2010. PMID: 20550929.
7. Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci 35(2):101-8, 2/2010. e-Pub 10/28/2009. PMID: 19875294.
8. Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 11(2):138-48, 2/2010. e-Pub 12/23/2009. PMID: 20029420.
9. Kim JE, Chen J, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle 8(18):2932-5, 9/2009. e-Pub 9/2009. PMCID: PMC2777512.
10. Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res 312(14):2641-2646, 8/15/2006. e-Pub 6/20/2006. PMID: 16893723.

Book Chapters

1. Lou ZK, chen JJ. Genome instability in cancer development. In: Advances in Experimental Medicine and Biology. 571. Ed(s) Nigg EA. Springer: New York, 425-455, 2005.
2. Lou Z, Chen J. Mammalian DNA damage response pathway. In: Adv Exp Med Biol. 570, 425-55, 2005. ISBN: 18727510.

Grant & Contract Support

Title: Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
Funding Source: National Institute on Alcohol Abuse and Alcoholism
Role: Co-Investigator
Principal Investigator: Mishra, Lopa
Duration: 9/30/2013 - 6/18/2018
 
Title: Fanconi anemia pathway in DNA damage repair
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 5/8/2012 - 3/31/2017
 
Title: Determine the roles of SOSS complexes in DNA damage repair and tumor suppression
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Project Leader
Principal Investigator: David Chen, Ph.D.
Duration: 7/1/2011 - 6/30/2016
 
Title: ERA of Hope Research Scholar Award: Systematic Investigation of Key Survival and Growth Pathways in Breast Cancer
Funding Source: Department of Defense (DOD)
Role: Principal Investigator
Duration: 9/1/2009 - 7/31/2015
 
Title: Study the role of Chfr in tumorigenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/1/2006 - 11/30/2016
 
Title: Analysis of BRCA1 function in DNA repair
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/1/2001 - 5/31/2016
 
Title: Study the role of DNA damage responses in tumorigenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/1/2001 - 5/31/2016

Last updated: 11/10/2014