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Keila E. Torres, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Assistant Professor, Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 1484
Houston, TX 77030

Education & Training

Degree-Granting Education

2003 Albert Einstein College of Medicine, Bronx, NY, MD, Medicine
2000 Albert Einstein College of Medicine, Bronx, NY, PHD, Molecular Pharmacology
1996 Albert Einstein College of Medicine, Bronx, NY, MS, Molecular Pharmacology
1994 University of Puerto Rico, Rio Piedras, Puerto Rico, BS, Magna Cum Laude, Chemistry

Postgraduate Training

7/2008-6/2011 Clinical Fellowship, Surgical Oncology Fellowship, MD Anderson Cancer Center, Houston, TX
7/2003-6/2008 Clinical Residency, General Surgery Residency, Robert Wood Johnson University, New Brunswick, NJ

Board Certifications

4/2010 American Board of Surgery

Professional Memberships

American College of Surgeons
Member, 2003-present
American Medical Association
Member, 1999-2003
Connective Tissue Oncology Society
Member, 2008-present
Curriculum Committee Member, General Surgery, Robert Wood Johnson University Hospital, New Brunswick, NJ
Member, 2003-2008
Harris Country Medical Society, Houston, TX
Member, 2008-present
International Health Care Volunteer, Cape Coast Africa
Volunteer, 2001-2003
Minority Association for Pre-Health Students Mentorship Program, Albert Einstein College of Medicine, Bronx, NY
Member, 1999-2003
Surgical Oncology Society
Member, 2008-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Roland CL, May CD, Watson KL, Al Sannaa GA, Dineen SP, Feig R, Landers S, Ingram DR, Wang WL, Guadagnolo BA, Feig B, Hunt KK, Cormier JN, Lazar AJ, Torres KE. Analysis of Clinical and Molecular Factors Impacting Oncologic Outcomes in Undifferentiated Pleomorphic Sarcoma. Ann Surg Oncol 23(7):2220-8, 7/2016. e-Pub 2/2016. PMCID: PMC4937623.
2. de Graaff MA, Yu JS, Beird HC, Ingram DR, Nguyen T, Juehui Liu J, Bolshakov S, Szuhai K, man P, Torres KE, Lev D, Nielsen TO, Bove JV, Lazar AJ, Somaiah N. Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation. Lab Invest. e-Pub 6/2016. PMID: 27270875.
3. Cleven AH, Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP, de Vries MW, Watson KL, Torres KE, Wang WL, van Duinen SG, Hogendoorn PC, Lazar AJ, Bove JV. Loss of H3K27 tri-methylation is a diagnostic marker for Malignant Peripheral Nerve Sheath Tumors and an indicator for an inferior survival. Mod Pathol 29(6):582-90, 6/2016. e-Pub 3/2016. PMCID: PMC4948583.
4. Bishop AJ, Zagars GK, Torres KE, Bird JE, Feig BW, Guadagnolo BA. Malignant Peripheral Nerve Sheath Tumors: A Single Institution's Experience Using Combined Surgery and Radiation Therapy. Am J Clin Oncol. e-Pub 6/2016. PMID: 27281262.
5. Roland CL, Boland GM, Demicco EG, Lusby K, Ingram D, May CD, Kivlin CM, Watson K, Al Sannaa GA, Wang WL, Ravi V, Pollock RE, Lev D, Cormier JN, Hunt KK, Feig BW, Lazar AJ, Torres KE. Clinical Observations and Molecular Variables of Primary Vascular Leiomyosarcoma. JAMA Surg 151(4):347-54, 4/2016. PMCID: PMC4941943.
6. Watson KL, Al Sannaa GA, Kivlin CM, Ingram DR, Landers SM, Roland CL, Cormier JN, Hunt KK, Feig BW, Ashleigh Guadagnolo B, Bishop AJ, Wang WL, Slopis JM, McCutcheon IE, Lazar AJ, Torres KE. Patterns of recurrence and survival in sporadic, neurofibromatosis Type 1-associated, and radiation-associated malignant peripheral nerve sheath tumors. J Neurosurg. e-Pub 4/2016. PMID: 27035165.
7. Kivlin CM, Watson KL, Al Sannaa GA, Belousov R, Ingram DR, Huang KL, May CD, Bolshakov S, Landers SM, Kalam AA, Slopis JM, McCutcheon IE, Pollock RE, Lev D, Lazar AJ, Torres KE. Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor. Cancer Biol Ther 17(2):129-38, 2/2016. e-Pub 12/2015. PMCID: PMC4847988.
8. Zhang P, Torres KE, Liu X, Liu CG, Pollock RE. An Overview of Chromatin-Regulating Proteins in Cells. Curr Protein Pept Sci 17(5):401-10, 2016. e-Pub 1/2016. PMCID: PMC4932839.
9. Bishop AJ, Zagars GK, Torres KE, Hunt KK, Cormier JN, Feig BW, Guadagnolo BA. Combined modality management of retroperitoneal sarcomas: a single institution series of 121 patients. Int J Radiat Oncol Biol Phys 93(1):158-65, 9/2015. e-Pub 5/2015. PMCID: PMC4928583.
10. Brudvik KW, Patel SH, Roland CL, Conrad C, Torres KE, Hunt KK, Cormier JN, Feig BW, Aloia TA, Vauthey JN. Survival After Resection of Gastrointestinal Stromal Tumor and Sarcoma Liver Metastases in 146 Patients. J Gastrointest Surg 19(8):1476-83, 8/2015. e-Pub 5/2015. PMCID: PMC4506212.
11. Keung E, Akdemir K, Al Sannaa G, Garnett J, Lev D, Torres KE, Lazar A, Rai K, Chin L. Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma. J Clin Investigation 125(8):2965-78, 7/2015. PMCID: PMCPMC4563740.
12. Keung E, Akdemir K, Al Sannaa G, Garnett J, Lev D, Torres KE, Lazar A, Rai K, Chin L. Integrated epigenomic and transcriptomic analyses identify Kruppel-like factor 6 (KLF6) as a H3K9me3 regulated tumor suppressor in liposarcoma. J Clin Investigation 125(8):2965-78, 7/2015.
13. Demicco EG, Harms PW, Patel RM, Smith SC, Ingram D, Torres K, Carskadon SL, Camelo-Piragua S, McHugh JB, Siddiqui J, Palanisamy N, Lucas DR, Lazar AJ, Wang WL. Extensive Survey of STAT6 Expression in a Large Series of Mesenchymal Tumors. Am J Clin Pathol 143(5):672-82, 5/2015. PMCID: PMC4505928.
14. Ikoma N, Torres KE, Somaiah N, Hunt KK, Cormier JN, Tseng W, Lev D, Pollock R, Wang WL, Feig B. Accuracy of Preoperative Percutaneous Biopsy for the Diagnosis of Retroperitoneal Liposarcoma Subtypes. Ann Surg Oncol 22(4):1068-72, 4/2015. e-Pub 10/2014. PMCID: PMCPMC4520392.
15. Demicco EG, Boland GM, Brewer Savannah KJ, Lusby K, Young ED, Ingram D, Watson KL, Bailey M, Guo X, Hornick JL, van de Rijn M, Wang WL, Torres KE, Lev D, Lazar AJ. Progressive Loss Of Myogenic Differentiation In Leiomyosarcoma Has Prognostic Value. Histopathology 66(5):627-38, 4/2015. e-Pub 1/2015. PMCID: PMC4248015.
16. Dineen SP, Roland CL, Feig R, May C, Zhou S, Demicco E, Sannaa GA, Ingram D, Wang WL, Ravi V, Guadagnolo A, Lev D, Pollock RE, Hunt K, Cormier J, Lazar A, Feig B, Torres KE. Radiation-Associated Undifferentiated Pleomorphic Sarcoma is Associated with Worse Clinical Outcomes than Sporadic Lesions. Ann Surg Oncol. e-Pub 3/2015. PMCID: PMC4561200.
17. Zhang P, Yang X, Ma X, Ingram DR, Lazar AJ, Torres KE, Pollock RE. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Mol Cancer 14(1):55, 2015. e-Pub 3/2015. PMCID: PMC4357176.
18. May CD, Garnett J, Ma X, Landers SM, Ingram DR, Demicco EG, Al Sannaa GA, Vu T, Han L, Zhang Y, Kivlin CM, Bolshakov S, Kalam AA, Liu J, Zhou F, Broccoli D, Wang WL, Lazar AJ, Pollock RE, Lev D, Torres KE. AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas. BMC Cancer 15:901, 2015. e-Pub 11/2015. PMCID: PMC4647521.
19. Chinyengetere F, Sekula DJ, Lu Y, Giustini AJ, Sanglikar A, Kawakami M, Ma T, Burkett SS, Eisenberg BL, Wells WA, Hoopes PJ, Demicco EG, Lazar AJ, Torres KE, Memoli V, Freemantle SJ, Dmitrovsky E. Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas. BMC Cancer 15:886, 2015. e-Pub 11/2015. PMCID: PMC4640382.
20. Bednarski BK, Araujo DM, Yi M, Torres KE, Lazar A, Trent JC, Cormier JN, Pisters PW, Lev DC, Pollock RE, Feig BW, Hunt KK. Analysis of prognostic factors impacting oncologic outcomes after neoadjuvant tyrosine kinase inhibitor therapy for gastrointestinal stromal tumors. Ann Surg Oncol 21(8):2499-505, 8/2014. e-Pub 3/2014. PMCID: PMC4524653.
21. Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P, Gundem G, Wedge DC, Ramakrishna M, Cooke SL, Pillay N, Vollan HK, Papaemmanuil E, Koss H, Bunney TD, Hardy C, Joseph OR, Martin S, Mudie L, Butler A, Teague JW, Patil M, Steers G, Cao Y, Gumbs C, Ingram D, Lazar AJ, Little L, Mahadeshwar H, Protopopov A, Al Sannaa GA, Seth S, Song X, Tang J, Zhang J, Ravi V, Torres KE, Khatri B, Halai D, Roxanis I, Baumhoer D, Tirabosco R, Amary MF, Boshoff C, McDermott U, Katan M, Stratton MR, Futreal PA, Flanagan AM, Harris A, Campbell PJ. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet 46(4):376-9, 4/2014. e-Pub 3/2014. PMCID: PMC4032873.
22. Satelli A, Mitra A, Cutrera JJ, Devarie M, Xia X, Ingram DR, Dibra D, Somaiah N, Torres KE, Ravi V, Ludwig JA, Kleinerman ES, Li S. Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells. Cancer Res 74(6):1645-50, 3/2014. e-Pub 1/2014. PMCID: PMC3959622.
23. Banda M, Speyer CL, Semma SN, Osuala KO, Kounalakis N, Torres KE, Barnard NJ, Kim HJ, Sloane BF, Miller FR, Goydos JS, Gorski DH. Metabotropic glutamate receptor-1 contributes to progression in triple negative breast cancer. PLoS One 9(1):e81126, 2014. e-Pub 1/2014. PMCID: PMC3880256.
24. Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE. Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. Cancer 119(10):1868-77, 5/2013. e-Pub 2/2013. PMID: 23401071.
25. Torres KE, Ravi V, Kin K, Yi M, Guadagnolo BA, May CD, Arun BK, Hunt KK, Lam R, Lahat G, Hoffman A, Cormier JN, Feig BW, Lazar AJ, Lev D, Pollock RE. Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer. Ann Surg Oncol 20(4):1267-74, 4/2013. e-Pub 12/2012. PMID: 23224828.
26. Ghadimi MP, Lopez G, Torres KE, Belousov R, Young ED, Liu J, Brewer KJ, Hoffman A, Lusby K, Lazar AJ, Pollock RE, Lev D. Targeting the PI3K/mTOR Axis, Alone and in Combination with Autophagy Blockade, for the Treatment of Malignant Peripheral Nerve Sheath Tumors. Mol Cancer Ther 11(8):1758-69, 8/2012. e-Pub 7/2012. PMCID: PMC3416967.
27. Torres K, Lazar A, Pollock R, Lev A. Angiosarcoma: A Frequently Recurrent and Highly Metastatic Malignancy. Eur J Clin Med Oncol 4(2):73-81, 7/2012.
28. Demicco EG, Torres KE, Ghadimi MP, Colombo C, Bolshakov S, Hoffman A, Peng T, Bove JV, Wang WL, Lev D, Lazar AJ. Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma. Mod Pathol 25(2):212-21, 2/2012. e-Pub 10/2011. PMCID: PMC3266971.
29. Ghadimi MP, Liu P, Peng T, Bolshakov S, Young ED, Torres KE, Colombo C, Hoffman A, Broccoli D, Hornick JL, Lazar AJ, Pisters P, Pollock RE, Lev D. Pleomorphic liposarcoma: Clinical observations and molecular variables. Cancer 117(23):5359-69, 12/2011. e-Pub 5/2011. PMCID: PMC3161152.
30. Lahat G, Zhang P, Zhu Q, Torres K, Ghadimi M, Smith KD, Wang W, Lazar AJ, Lev D. Molecular subclassification of unclassified pleomorphic sarcoma (UPS/MFH). Histopathology 59(1):556-561, 9/2011.
31. Lahat G, Zhang P, Zhu QS, Torres K, Ghadimi M, Smith KD, Wang WL, Lazar AJ, Lev D. The expression of c-Met pathway components in unclassified pleomorphic sarcoma/malignant fibrous histiocytoma (UPS/MFH): a tissue microarray study. Histopathology 59(3):556-61, 9/2011. PMID: 22034893.
32. Torres KE, Liu J, Young E, Huang KL, Ghadimi M, Lusby K, Lazar AJ, Lev D. Expression of 'drugable' tyrosine kinase receptors in malignant peripheral nerve sheath tumour: potential molecular therapeutic targets for a chemoresistant cancer. Histopathology 59(1):156-9, 7/2011. PMCID: PMC4532392.
33. Torres KE, Zhu QS, Bill K, Lopez G, Ghadimi MP, Xie X, Young ED, Liu J, Nguyen T, Bolshakov S, Belousov R, Wang S, Lahat G, Liu J, Hernandez B, Lazar AJ, Lev D. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res 17(12):3943-55, 6/2011. e-Pub 5/2011. PMCID: PMC3117912.
34. Lopez G, Torres K, Lev D. Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: Potential implications for the treatment of a therapeutic-resistant malignancy. Autophagy 7(4). e-Pub 4/2011. PMCID: PMC3127223.
35. Lopez G, Torres K, Liu J, Hernandez B, Young E, Belousov R, Bolshakov S, Lazar AJ, Slopis JM, McCutcheon IE, McConkey D, Lev D. Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors. Cancer Res 71(1):185-96, 1/2011. e-Pub 11/2010. PMCID: PMC3064267.
36. Ylip A, Hunt KK, Yang J, Lazar AJ, Torres KE, Lev DC, Nykter M, Pollock RE, Trent J, Zhang W. Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors. Cancer 117(2):380-9, 1/2011. e-Pub 9/2010. PMCID: PMC3008331.
37. Wang S, Ren W, Liu J, Lahat G, Torres K, Lopez G, Lazar AJ, Hayes-Jordan A, Liu K, Bankson J, Hazle JD, Lev D. TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo. Clin Cancer Res 16(9):2591-604, 5/2010. e-Pub 4/2010. PMCID: PMC2967255.
38. Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One 5(4):e10105, 2010. e-Pub 4/2010. PMCID: PMC2855704.
39. Torres KE, Burd RS. Recent nationwide trends in the utilization of pectus repairs in children. J Surg Res 137(2):328-329, 2007.
40. Gorski D, Schell SR, Kounalakis N, Torres K, Barnard NJ, Goydos JS, Chen S. Elevated metabotropic glutamate receptor expression: a novel finding in invasive breast cancer. J Surg Res 130(2):164, 2006.
41. Gold JP, Torres KE, Maldarelli W, Zhuravlev I, Condit D, Wasnick J. Improving outcomes in coronary surgery: the impact of echo-directed aortic cannulation and perioperative hemodynamic management in 500 patients. Ann Thorac Surg 78(5):1579-85, 11/2004. PMID: 15511435.
42. Gold JP, Wasnick J, Maldarelli W, Zhuraavlev I, Torres KE, Condit D. Selective use of off-pump coronary bypass surgery reduces mortality and neurologic morbidity associated with high-risk coronary bypass surgery: a 400-case comparative experience. Heart Surg Forum 7(6):E562-8, 2004. PMID: 15769687.
43. Martello LA, Verdier-Pinard P, Shen HJ, He L, Torres K, Orr GA, Horwitz SB. Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation. Cancer Res 63(6):1207-13, 3/2003. PMID: 12649178.
44. Torres K, Horwitz SB. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 58(16):3620-6, 8/1998. PMID: 9721870.
45. Bez A, Torres K, Tan EM, Pommier Y, Casiano CA. Expression of proliferation-associated nuclear autoantigens, p330d/CENP-F and PCNA, in differentiation and in drug-induced growth inhibition using two-parameter flow cytometry. Cell Prolif 29(4):183-96, 4/1996. PMID: 8695747.
46. Goldwasser F, Bae I, Valenti M, Torres K, Pommier Y. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. Cancer Res 55(10):2116-21, 5/1995. PMID: 7743511.
47. Voss et al, Chiang, YJ, Guadagnolo BA, Torres KE, Mann GN, Hunt KK, Feig BW, Cormier JN, Roland CL. Adherence to NCCN Guidelines and Risk Factors for Non-Adherence in Stage IIA & IIB/III Extremity and Trunk Soft Tissue Sarcoma. JCO. Submitted.
48. Voss et al, Chiang, YJ, Guadagnolo BA, Torres KE, Mann GN, Hunt KK, Feig BW, Cormier JN, Roland CL. Adherence to NCCN Guidelines is Associated with Improved Survival in Patients with Stage IIA & IIB/III Extremity and Trunk Soft Tissue Sarcoma. JCO. Submitted.
49. Young ED, Ingram D, Metcalf-Doetsch W, Khan D, A Al Sannaa G, Le Loarer F, Lazar AJ, Slopis J, Torres KE, Lev D, Pollock RE, McCutcheon IE. Clinicopathologic Variables of Sporadic Peripheral Schwannoma in a Large Cohort of Patients and Expression of Biologically Relevant Markers. J Neurosurg. Submitted.
50. May CD, Ma XM, Landers SM, Ingram DR, 
Al Sannaa GA, Kivlin CM, Bolshakov S, Lazar A, Pollock RE, Lev D, and Torres KE. Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for the treatment of undifferentiated pleomorphic sarcoma. Mol Cancer Ther. Submitted.
51. Landers SM, Ma XM, May CD, Ingram DR, 
Al Sannaa GA, Lazar A, Torres KE. Inhibition of AXL enhances the sensitivity of malignant peripheral nerve sheath tumors to MEK inhibition. Clinical Cancer Research. Submitted.
52. Sannaa GA, Watson KL, Wang WL, Fuller GN, McCutcheon I, Torres KE, Lazar AJ. Sarcoma Brain Metastases: 28 years of Experience at a Single Institution. Ann Surg Oncol. Submitted.

Book Chapters

1. Roland C, Wang WL, Lazar AJ, Torres KE. Myxofibrosarcoma. In: Surgical Oncology Clinics of NA. Ed(s) Raut C Elsevier Inc, 2016.
2. Torres K, Pisters PW. Malignant fibrous histiocytoma. In: Sarcoma Oncology: A Multidisciplinary Approach. Ed(s) Pollock RE, Baker LH, O'Sullivan B, Randall RL. People's Medical Publishing House-USA, Ltd: China, 2014.
3. Brewer K, Torres KE, Lev D. Tumor Microenvironment Cross-Talk; a Process Critical for Sarcoma Progression and Metastasis. In: Sarcoma Oncology: A Multidisciplinary Approach. Ed(s) Pollock RE, Baker LH, O'Sullivan B, Randall RL. People's Medical Publishing House - USA, Ltd. China, 2014.
4. Torres K, Pollock RE. Soft Tissue Sarcomas. In: New EBM Textbook of Elective General Surgery. Ed(s) Cohn S, Brower S. People's Medical Publishing House - USA, Ltd. China, 2012.
5. Torres K, Hunt KK, Pollock RE. Forequarter Amputation. In: Master Techniques in Breast Surgery. Ed(s) Klimberg S, Bland K. Lippincott Williams & Wilkins: New York, 2010.
6. Torres K, Pollock RE. Gene-based therapies for cancer. In: Cancer Research. Ed(s) Roth J. Springer: New York, 2010.

Manuals, Teaching Aids, Other Teaching Publications

1. Torres KE, Zhu Q, Lev D. Targeting the P13K/AKT Pathway in UPS/MFH. 8, 5. Electronic Sarcoma Update Newsletter (ESUN): http://sarcomahelp.org/research_center/UPS-MFH_study.html, 10/2011.
2. Torres K, Pollock RE. Alveolar Soft Part Sarcoma. 7, 6. Electronic Sarcoma Update Newsletter (ESUN): http://sarcomahelp.org/learning_center/asps.html, 12/2010.
3. Moufflet A, Moore J, Panarelli A, Madrid D, Schimmrich K, Pevzner L, Torres K, Angel M, Zahtz E, Sorbellini M, Koppolu S, Cuevas J, Frogel D, Grinspan Z, Spector J, Hirsh D, Vouyiouklis M. AECOM Dissector Online. http://storm.aecom.yu.edu/virtualDissector, Chapter 3, Section 2, 7, & 8, 2001.

Last updated: 8/12/2016