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Kevin M. McBride, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Epigenetics and Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX

Office Address

The University of Texas MD Anderson Cancer Center
1808 Park Road 1C
PO Box 958
Unit Number: 0116
Smithville, TX 78957
Phone: 512.237.9338
Fax: 512.237.6532

Education & Training

Degree-Granting Education

2000 Stony Brook University, Stony Brook, NY, PHD, Molecular and Cellular Pathology
1994 Worcester Polytechnic Institute, Worcester, MA, BS, Biotechnology

Postgraduate Training

2007-2011 Research Associate, Rockefeller University, New York, NY, Michel C. Nussenzweig, MD, PhD
2002-2007 Postdoctoral Fellow, Rockefeller University, New York, NY, Michel C. Nussenzweig, MD, PhD
2001-2002 Postdoctoral Associate, Stony Brook University, Stony Brook, NY, Nancy C. Reich, PhD


Institutional Committee Activities

Member, Department of Molecular Carcinogenesis Faculty Search Committee, 2012

Honors and Awards

2013 MD Anderson Cancer Center, Leukemia SPORE Career Development Award, The University of Texas MD Anderson Cancer Center
2011 University of Texas Systems, STARS Recruitment Award, University of Texas Systems
2003-2006 NIH Postdoctoral Training Fellowship
2002 Aaron Janoff award for excellence in experimental pathology, Stony Brook University

Selected Publications

Peer-Reviewed Original Research Articles

1. Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1. ACS Chem Biol 10(4):1072-81, 4/17/2015. e-Pub 1/28/2015. PMCID: PMC4402254.
2. Kracker S, Di Virgilio M, Schwartzentruber J, Cuenin C, Forveille M, Deau MC, McBride KM, Majewski J, Gazumyan A, Seneviratne S, Grimbacher B, Kutukculer N, Herceg Z, Cavazzana M, Jabado N, Nussenzweig MC, Fischer A, Durandy A. An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol 135(4):998-1007.e6, 4/2015. e-Pub 10/11/2014. PMCID: PMC4382329.
3. Minkah N, Macaluso M, Oldenburg DG, Paden CR, White DW, McBride KM, Krug LT. Absence of the Uracil DNA Glycosylase of Murine Gammaherpesvirus 68 Impairs Replication and Delays the Establishment of Latency In Vivo. J Virol 89(6):3366-79, 3/15/2015. e-Pub 1/14/2015. PMCID: PMC4337548.
4. Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, Wood RD. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet 10(10):e1004654, 10/2014. e-Pub 10/2014. PMCID: PMC4183433.
5. Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT. Arginine methylation facilitates the recruitment of TOP3 to chromatin to prevent R-loop accumulation. Mol Cell 53(3):484-97, 2/2014. e-Pub 2013. PMCID: PMC3959860.
6. Yates JL, Racine R, McBride KM, Winslow GM. T Cell-Dependent IgM Memory B Cells Generated during Bacterial Infection Are Required for IgG Responses to Antigen Challenge. Journal of Immunology 191(3), 6/2013. PMCID: PMC3720767.
7. Gazumyan A, Bothmer A, Klein IA, Nussenzweig MC, McBride KM. Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res 113(113):167-90, 2012. PMCID: PMC4353630.
8. Gazumyan A, Timachova K, Yuen G, Siden E, Di Virgilio M, Woo EM, Chait BT, Reina San-Martin B, Nussenzweig MC, McBride KM. Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol Cell Biol 31(3):442-9, 2/2011. e-Pub 12/2010. PMCID: PMC3028632.
9. Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride KM, Nussenzweig MC, Casellas R. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12(1):62-9, 1/2011. e-Pub 11/2010. PMCID: PMC3005028.
10. Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 36(4):631-41, 11/2009. PMCID: PMC2805907.
11. McBride KM, Gazumyan A, Woo EM, Schwickert TA, Chait BT, Nussenzweig MC. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205(11):2585-94, 10/2008. e-Pub 10/2008. PMCID: PMC2571933.
12. Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 28(5):630-8, 5/2008. e-Pub 5/2008. PMCID: PMC2713656.
13. Shen HM, Bozek G, Pinkert CA, McBride KM, Wang L, Kenter A, Storb U. Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. Mol Immunol 45(7):1883-92, 4/2008. e-Pub 12/2007. PMCID: PMC2376253.
14. Chatterji M, Unniraman S, McBride KM, Schatz DG. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179(8):5274-80, 10/2007. PMID: 17911613.
15. Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride KM, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 130(1):63-75, 7/2007. e-Pub 6/2007. PMID: 17599403.
16. Ramiro A, Reina San-Martin B, McBride KM, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Adv Immunol 94:75-107, 2007. PMID: 17560272.
17. McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, Chait BT, Nussenzweig MC. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A 103(23):8798-803, 6/2006. e-Pub 5/2006. PMCID: PMC1482658.
18. Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440(7080):105-9, 3/2006. e-Pub 1/2006. PMID: 16400328.
19. Liu L, McBride KM, Reich NC. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A 102(23):8150-5, 6/2005. e-Pub 5/2005. PMCID: PMC1149424.
20. McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med 199(9):1235-44, 5/2004. e-Pub 4/2004. PMCID: PMC2211910.
21. Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 12(2):501-8, 8/2003. PMID: 14536088.
22. McBride KM, Reich NC. The ins and outs of STAT1 nuclear transport. Sci STKE 2003(195):RE13, 8/2003. e-Pub 8/2003. PMID: 12915721.
23. Brown MT, McBride KM, Baniecki ML, Reich NC, Marriott G, Mangel WF. Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton. J Biol Chem 277(48):46298-303, 11/2002. e-Pub 8/2002. PMID: 12191991.
24. McBride KM, Banninger G, McDonald C, Reich NC. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J 21(7):1754-63, 4/2002. PMCID: PMC125956.
25. McBride KM, McDonald C, Reich NC. Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor. EMBO J 19(22):6196-206, 11/2000. PMCID: PMC305830.
26. Kumar KP, McBride KM, Weaver BK, Dingwall C, Reich NC. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol 20(11):4159-68, 6/2000. PMCID: PMC85785.

Book Chapters

1. McBride KM, Reich NC. Nuclear trafficking of STAT proteins. In: Signal transducers and activators of transcription (STATs): activation and biology. Ed(s) PB Seghal, DE Levy, T Hirano. Dordrecht: London: Kluwer Academic, Chapter 18, 2003.

Grant & Contract Support

Title: Cytidine Deamination and DNA Demethylation During Development
Funding Source: UT MD Anderson Cancer Center
Role: Principal Investigator
Duration: 4/1/2015 - 3/31/2016
Title: Genome Stability and Immune Diversity Controlled by the POLQ Pathway
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 3/1/2015 - 2/28/2018
Title: Creation of Modification Specific Monoclonal Antibodies by Single Cell Cloning
Funding Source: UTMDACC Center for Cancer Epigenetics
Role: Principal Investigator
Duration: 7/1/2014 - 3/30/2016
Title: Small molecule inhibitors of epigenetic effector proteins
Funding Source: WELCH Foundation
Role: Principal Investigator
Duration: 6/1/2014 - 5/31/2017
Title: Uracil DNA glycosylase function in herpesvirus pathogenesis and DNA mutation
Funding Source: NIH/NIAID
Role: Co-Investigator
Principal Investigator: Laurie T. Krug
Duration: 4/1/2014 - 3/31/2016

Last updated: 12/1/2015