Kevin M. McBride, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Associate Professor, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Smithville, TX
Education & Training
Degree-Granting Education
| 2000 | Stony Brook University, Stony Brook, NY, USA, PHD, Molecular and Cellular Pathology |
| 1994 | Worcester Polytechnic Institute, Worcester, MA, USA, BS, Biotechnology |
Postgraduate Training
| 2007-2011 | Research Associate, Rockefeller University, New York, NY |
| 2002-2007 | Postdoctoral Fellow, Rockefeller University, New York, NY |
| 2001-2002 | Postdoctoral Associate, Stony Brook University, Stony Brook, NY |
Experience & Service
Academic Appointments
Member, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, 2012 - Present
Assistant Professor, Department of Epigenetics and Molecular Carcinogenesis, Division of Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2011 - 2018
Administrative Appointments/Responsibilities
Director: Recombinant Antibody Production Core, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2018 - Present
Associate Director: Science Park Summer Undergraduate Research Program in Cancer, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2014 - 2021
Other Appointments/Responsibilities
senator, UTMDACC, Houston, TX, 2021 - Present
Member, Center for Molecular & Cellular Toxicology, Austin, TX, 2013 - Present
Institutional Committee Activities
Member, TMC3 Think Tank, UTMDACC, 2020 - Present
Member, TMC3 Vivarium Think Tank, UTMDACC, 2020 - Present
Member, Advisory Committee for Breeder Animal Movement, UTMDACC, 2020 - Present
Member, Kopchick Research Award Review Committee, 2018 - 2020
Member, Genetics and Epigenetics Program Community Committee, GSBS, 2018 - Present
Member, Recruitment Committee, Genetics and Epigenetic Program, 2017 - Present
Member, Department of Epigenetics and Molecular Carcinogenesis Faculty Search Committee, 2016 - 2017
Member, Steering Committee, Epigenetics and Molecular Carcinogenesis Program, 2015 - 2017
Member, Postdoctoral Advisory Committee, 2014 - 2017
Member, Faculty Academic Review Committee (FARC), 2014 - Present
Member, Admissions Committee, Epigenetics and Molecular Carcinogenesis Program, 2013 - 2017
Member, Department of Molecular Carcinogenesis Faculty Search Committee, 2012 - 2012
Member, Faculty Senator, 2012 - 2015
Member, Graduate School of Biomedical Science (GSBS) Student Scholarship Committee, 2012 - 2016
Honors & Awards
| 2013 | MD Anderson Cancer Center, Leukemia SPORE Career Development Award, The University of Texas MD Anderson Cancer Center |
| 2011 | University of Texas Systems, STARS Recruitment Award, University of Texas Systems |
| 2003 | NIH Postdoctoral Training Fellowship |
| 2002 | Aaron Janoff award for excellence in experimental pathology, Stony Brook University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Mu Y, Zelazowska MA, Chen Z, Plummer JB, Dong Q, Krug LT, McBride KM. Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. DNA Repair (Amst) 128:103515, 2023. e-Pub 2023. PMID: 37315375.
- Mu Y, Plummer JB, Zelazowska MA, Paul S, Dong Q, Chen Z, Krug LT, McBride KM. A Recombinant Antibody For Tracking Murine Gammaherpesvirus 68 Uracil DNA Glycosylase Expression. bioRxiv, 2023. e-Pub 2023. PMID: 37293087.
- Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues. bioRxiv, 2023. e-Pub 2023. PMID: 37398059.
- Liu KJ, Zelazowska MA, McBride KM. The Longitudinal Analysis of Convergent Antibody VDJ Regions in SARS-CoV-2-Positive Patients Using RNA-Seq. Viruses 15(6), 2023. e-Pub 2023. PMID: 37376553.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Characterization of a mouse model of ICF syndrome reveals enhanced CD19 activation in inducing hypogammaglobulinemia. bioRxiv, 2023. e-Pub 2023. PMID: 36945532.
- Hogan CH, Owens SM, Reynoso GV, Kirillov V, Meyer TJ, Zelazowska MA, Liu B, Li X, Chikhalya A, Dong Q, Khairallah C, Reich NC, Sheridan B, McBride KM, Hearing P, Hickman HD, Forrest JC, Krug LT. B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model. bioRxiv, 2023. e-Pub 2023. PMID: 36993230.
- Farria AT, Plummer JB, Salinger AP, Shen J, Lin K, Lu Y, McBride KM, Koutelou E, Dent SYR. Transcriptional activation of Myc-induced genes by Gcn5 promotes B cell lymphomagenesis. Cancer Res 80(24):5543-5553, 2020. e-Pub 2020. PMID: 33168647.
- Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI. Defining the mutation signatures of DNA polymerase θ in cancer genomes. NAR Cancer 2(3):https://academic.oup.com/narcancer/article/2/3/zcaa017/5898153, 2020. e-Pub 2020. PMID: 32885167.
- Zelazowska, MA, McBride, KM, Krug, LT. Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire. Viruses 12(8):788, 2020.
- Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein Cell 11(3):214-218, 2020. e-Pub 2020. PMID: 31970665.
- Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM. Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire. Life Sci Alliance 3(3), 2020. e-Pub 2020. PMID: 32029571.
- Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S, Davies MA, Hwu P, Lee JE, Gershenwald JE, Lucci A, Arora R, Woodman S, Keung EZ, Gaudreau PO, Reuben A, Spencer CN, Burton EM, Haydu LE, Lazar AJ, Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM, Kalluri R, Allison J, Petitprez F, Fridman WH, Sautès-Fridman C, Hacohen N, Rezvani K, Sharma P, Tetzlaff MT, Wang L, Wargo JA. B-cells and tertiary lymphoid structures promote immunotherapy response. Nature 577(7791):549-555, 2020. e-Pub 2020. PMID: 31942075.
- McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM. Wwox Deletion in mouse B Cells leads to genomic instability, neoplastic transformation and monoclonal gammopathies. Front Oncol 9:517, 2019. e-Pub 2019. PMID: 31275852.
- Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT. Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. MBio 9(5), 2018. e-Pub 2018. PMID: 30377280.
- Mu Y, McBride KM. Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association. Mol Cell Oncol 5(5):e1432259, 2018. e-Pub 2018. PMID: 30263937.
- Mu Y, Zelazowska MA, McBride KM. Phosphorylation Promotes Activation-Induced Cytidine Deaminase Activity at the Myc Oncogene. J Exp Med 214(12):3543-3552, 2017. e-Pub 2017. PMID: 29122947.
- Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD. Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet 13(6):e1006818, 2017. e-Pub 2017. PMID: 28570559.
- Kracker S, Di Virgilio M, Schwartzentruber J, Cuenin C, Forveille M, Deau MC, McBride KM, Majewski J, Gazumyan A, Seneviratne S, Grimbacher B, Kutukculer N, Herceg Z, Cavazzana M, Jabado N, Nussenzweig MC, Fischer A, Durandy A. An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol 135(4):998-1007.e6, 2015. e-Pub 2014. PMID: 25312759.
- Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1. ACS Chem Biol 10(4):1072-81, 2015. e-Pub 2015. PMID: 25590533.
- Minkah N, Macaluso M, Oldenburg DG, Paden CR, White DW, McBride KM, Krug LT. Absence of the Uracil DNA Glycosylase of Murine Gammaherpesvirus 68 Impairs Replication and Delays the Establishment of Latency In Vivo. J Virol 89(6):3366-79, 2015. e-Pub 2015. PMID: 25589640.
- Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, Wood RD. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet 10(10):e1004654, 2014. e-Pub 2014. PMID: 25275444.
- Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT. Arginine methylation facilitates the recruitment of TOP3 to chromatin to prevent R-loop accumulation. Mol Cell 53(3):484-97, 2014. e-Pub 2013. PMID: 24507716.
- Yates JL, Racine R, McBride KM, Winslow GM. T Cell-Dependent IgM Memory B Cells Generated during Bacterial Infection Are Required for IgG Responses to Antigen Challenge. Journal of Immunology 191(3), 2013. PMID: 23804710.
- Gazumyan A, Timachova K, Yuen G, Siden E, Di Virgilio M, Woo EM, Chait BT, Reina San-Martin B, Nussenzweig MC, McBride KM. Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol Cell Biol 31(3):442-9, 2011. e-Pub 2010. PMID: 21135131.
- Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride KM, Nussenzweig MC, Casellas R. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12(1):62-9, 2011. e-Pub 2010. PMID: 21113164.
- Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 36(4):631-41, 2009. PMID: 19941823.
- McBride KM, Gazumyan A, Woo EM, Schwickert TA, Chait BT, Nussenzweig MC. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205(11):2585-94, 2008. e-Pub 2008. PMID: 18838546.
- Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 28(5):630-8, 2008. e-Pub 2008. PMID: 18455451.
- Shen HM, Bozek G, Pinkert CA, McBride KM, Wang L, Kenter A, Storb U. Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. Mol Immunol 45(7):1883-92, 2008. e-Pub 2007. PMID: 18067961.
- Chatterji M, Unniraman S, McBride KM, Schatz DG. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179(8):5274-80, 2007. PMID: 17911613.
- Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride KM, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 130(1):63-75, 2007. e-Pub 2007. PMID: 17599403.
- Ramiro A, Reina San-Martin B, McBride KM, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Adv Immunol 94:75-107, 2007. PMID: 17560272.
- McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, Chait BT, Nussenzweig MC. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A 103(23):8798-803, 2006. e-Pub 2006. PMID: 16723391.
- Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440(7080):105-9, 2006. e-Pub 2006. PMID: 16400328.
- Liu L, McBride KM, Reich NC. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A 102(23):8150-5, 2005. e-Pub 2005. PMID: 15919823.
- McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med 199(9):1235-44, 2004. e-Pub 2004. PMID: 15117971.
- Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 12(2):501-8, 2003. PMID: 14536088.
- McBride KM, Reich NC. The ins and outs of STAT1 nuclear transport. Sci STKE 2003(195):RE13, 2003. e-Pub 2003. PMID: 12915721.
- Brown MT, McBride KM, Baniecki ML, Reich NC, Marriott G, Mangel WF. Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton. J Biol Chem 277(48):46298-303, 2002. e-Pub 2002. PMID: 12191991.
- McBride KM, Banninger G, McDonald C, Reich NC. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J 21(7):1754-63, 2002. PMID: 11927559.
- McBride KM, McDonald C, Reich NC. Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor. EMBO J 19(22):6196-206, 2000. PMID: 11080165.
- Kumar KP, McBride KM, Weaver BK, Dingwall C, Reich NC. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol 20(11):4159-68, 2000. PMID: 10805757.
Invited Articles
- Gazumyan A, Bothmer A, Klein IA, Nussenzweig MC, McBride KM. Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res 113(113):167-90, 2012. PMID: 22429855.
Book Chapters
- McBride KM, Reich NC. Nuclear trafficking of STAT proteins. In: Signal transducers and activators of transcription (STATs): activation and biology. Dordrecht: London: Kluwer Academic, Chapter 18, 2003.
Grant & Contract Support
| Title: | Start-up funds from institutional resources that are used to help initiate research activities |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Genome Stability and Immune Diversity Controlled by the POLQ Pathway |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Modeling ICF syndrome in mice: Role of Zbtb24 in DNA methylation and antibody production |
| Funding Source: | NIH/NIAID |
| Role: | Co-Investigator |
| Title: | Uracil DNA Glycosylases in Gammaherpesvirus Pathogenesis and B Cell Development |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | MD Anderson Science Park Summer Program in Cancer Research |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Tobacco Related Cancer Pilot |
| Funding Source: | Tobacco Pilot Award, The University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Roll of WWOX Loss of Function in High Risk Multiple Myeloma |
| Funding Source: | Leukemia and Lymphoma Society |
| Role: | Co-Investigator |
| Title: | |
| Funding Source: | Three Strohm Sisters Family Foundation |
| Role: | Principal Investigator |
| Title: | Development of Antibodies That Detect Oncogenic Point Mutations in Lung Cancer |
| Funding Source: | Tobacco Pilot Award, The University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Recombinant Antibody Production Core (RAPC) at Science Park |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Targeting B cells to enhance responses to immune checkpoint blockade |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Harnessing tertiary lymphoid structure function for improved immunotherapeutic strategies in cancer patients |
| Funding Source: | The Mark Foundation for Cancer Research/The University of Pittsburgh |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified June 27, 2024