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Lauren Averett Byers, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2009 University of Texas Graduate School of Biomedical Sciences, Houston, TX, MS, Cancer Biology (specialization in Patient-Based Research)
2003 Baylor College of Medicine, Houston, TX, MD, N/A
1998 Princeton University, Princeton, NJ, BA, Molecular Biology

Postgraduate Training

7/2009-7/2010 Advanced Scholars Program, Medical Oncology Research, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Waun Ki Hong
7/2006-6/2009 Clinical Fellowship, Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Robert A. Wolff, Program Director
7/2003-6/2006 Clinical Residency, Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, Charles Wiener, Program Director

Honors and Awards

2010 Clinical Research Loan Repayment Program, NIH
2010 Scholar-in-Training Award, AACR Annual Meeting
2009 Achievement in Basic Science Research Award, Division of Cancer Medicine/Medical Oncology Fellowship, The University of Texas M. D. Anderson Cancer Center
2009 Merit Award, ASCO Annual Meeting, American Society of Clinical Oncology
2009 Trainee Research Day Poster Finalist, Postgraduate Clinical/Translational Research, The University of Texas M. D. Anderson Cancer Center
2008 Clinical Fellow Award, A. Lavoy Moore Endowment Fund, The University of Texas M. D. Anderson Cancer Center
2008 Clinical Research Loan Repayment Program, NIH
2008 First Prize, Bristol-Myers Squibb Poster Award, Postgraduate Clinical/Translational Research, The University of Texas M. D. Anderson Cancer Center
2008 Merit Award, ASCO Annual Meeting, American Society of Clinical Oncology
2008 Merit Award, ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer, American Society for Clinical Oncology
2008 Merit Award, IASCL 8th Annual Targeted Therapies for the Treatment of Lung Cancer Meeting, International Association for the Study of Lung Cancer
2008 Trainee Excellence Award, The University of Texas M. D. Anderson Cancer Center
2007 Merit Award, AACR-NCI-EORTC Molecular Targets Meeting, American Association for Cancer Research
2002 First Prize Basic Science Research, J. Alexander Research Symposium, Baylor College of Medicine

Selected Publications

Peer-Reviewed Original Research Articles
1. Wang J, Byers LA, Yordy JS, Liu W, Shen L, Baggerly K, GiriU, Myers JN, Ang KK, Story MD, Girard L, Minna JD, Heymach JV, Coombes KR. Blasted Cell Line Names. Cancer Informatics. In Press.
2. Nanjundan M, Byers LA, Carey MS, Siwak DR, Raso MG, Diao L, Wang J, Coombes KR, Roth JA, Mills GB, Wistuba II, Minna JD, Heymach, JV. Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. Journal of Thoracic Oncology. In Press.
3. Cai D, Shames DS, Raso MG, Xie Y, Kim YH, Pollack JR, Girard L, Sullivan JP, Gao B, Peyton M, Nanjundan M, Byers L, Heymach J, Mills G, Gazdar AF, Wistuba I, Kodadek T, Minna JD. Steroid Receptor Coactivator-3 Expression in Lung Cancer and Its Role in the Regulation of Cancer Cell Survival and Proliferation. Cancer Res 70(16):6477-6485, 8/15/2010. e-Pub 7/27/2010. PMCID: PMC2922434.
4. Byers LA, Holsinger FC, Kies MS, William WN, El-Naggar AK, Lee JJ, Hu J, Lopez A, Tran HT, Yan S, Du Z, Ang KK, Glisson BS, Raso MG, Wistuba II, Myers JN, Hong WK, Papadimitrakopoulou V, Lippman SM, Heymach JV. Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer. Mol Cancer Ther 9(6):1755-63, 6/2010. e-Pub 6/8/2010. PMCID: PMC2913168.
5. Kies MS, Holsinger FC, Lee JJ, William WN, Glisson BS, Lin HY, Lewin JS, Ginsberg LE, Gillaspy KA, Massarelli E, Byers L, Lippman SM, Hong WK, El-Naggar AK, Garden AS, Papadimitrakopoulou V. Induction Chemotherapy and Cetuximab for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results From a Phase II Prospective Trial. J Clin Oncol 28(1):8-14, 1/1/2010. e-Pub 11/16/2009. PMCID: PMC2799235.
6. Byers LA, Sen B, Saigal B, Diao L, Wang J, Nanjundan M, Cascone T, Mills GB, Heymach JV, Johnson FM. Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer. Clin Cancer Res 15(22):6852-61, 11/15/2009. e-Pub 10/27/2009. PMCID: PMC2935176.
7. Naumov GN, Nilsson MB, Cascone T, Briggs A, Straume O, Akslen LA, Lifshits E, Byers LA, Xu L, Wu HK, Jänne P, Kobayashi S, Halmos B, Tenen D, Tang XM, Engelman J, Yeap B, Folkman J, Johnson BE, Heymach JV. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res 15(10):3484-94, 5/15/2009. e-Pub 5/15/2009. PMCID: PMC2893040.
8. Ko N, Averett L, Brown C, Wiener CM. An unexpected finding. Am J Med 118(5):477-9, 5/2005. PMID: 15866248.
9. Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 3(2):185-97, 2/2003. PMID: 12620412.
10. Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 346(25):1937-47, 6/2002. PMID: 12075054.
11. Lam LT, Pickeral OK, Peng AC, Rosenwald A, Hurt EM, Giltnane JM, Averett LM, Zhao H, Davis RE, Sathyamoorthy M, Wahl LM, Harris ED, Mikovits JA, Monks AP, Hollingshead MG, Sausville EA, Staudt LM. Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol 2(10):RESEARCH0041, 2001. e-Pub 9/2001. PMCID: PMC57796.

Invited Articles
1. Byers LA, Heymach JV. Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: rationale and clinical applications for non-small-cell lung cancer. Clin Lung Cancer 8 Suppl 2:S79-85, 2/2007. PMID: 17382029.

Abstracts
1. Yordy JS, Byers LA, Davies M, Mills GB, Ju Z, Raju U, Ang K, Heymach JV. Yordy JS, Byers LA, Davies M, Mills GB, Ju Z, Raju U, Ang K, Heymach JV. Proceedings of the 2008 ASCO-NCI-EORTC Molecular Markers Meeting; 2008 Oct 30-Nov 1; Hollywood, FL, 2008.

Grant & Contract Support

Title: Clinical Validation of Predictive Markers Identified by Whole Genome SNP Array Profiling of Head and Neck Squamous Cell Cancer Cell Lines
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/26/2010 - 7/26/2011
 
Title: AACR-AstraZeneca-Prevent Cancer Foundation Fellowship for Translational Lung Cancer Research
Funding Source: American Association for Cancer Research (AACR)
Role: Principal Investigator
Duration: 7/1/2008 - 6/30/2011
 
Title: Young Clinical Scientist Award
Funding Source: Flight Attendant Medical Research Institute
Role: Consultant
Principal Investigator: Matt Herynk
Duration: 7/1/2008 - 7/1/2010
 
Title: Young Investigator Award
Funding Source: American Society of Clinical Oncology (ASCO)
Role: Principal Investigator
Duration: 7/1/2008 - 12/31/2009
 
Title: Developmental Research Project Award
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: John V. Heymach
Duration: 9/1/2007 - 4/30/2010
 
Title: Project 1, University of Texas SPORE in Lung Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: John D. Minna
Duration: 9/1/1998 - 4/30/2013

Last updated: 11/10/2010