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Laurence E. Court, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor Tenure Track, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Assistant Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Regular Faculty Member, School of Health Professions, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX
Regular Faculty Member, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1420
Houston, TX 77030-3722
Phone: 713-563-2546
Fax: 713-563-2545
Email: lecourt@mdanderson.org

Education & Training

Degree-Granting Education

1995 University College London, London, United Kingdom, Ph.D., Medical Physics
1992 University College London, London, United Kingdom, B.Sc., First-Class, Physics with Medical Physics

Postgraduate Training

1/2007-12/2007 Leadership Institute, Babson College/Dana-Farber Cancer Institute, Boston, MA
1/2002-12/2003 Research Fellowship, Medical Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, Lei Dong
1/2000-8/2001 Certificate, Management, Engineering Management Partnership, Sheffield, United Kingdom
10/1995-6/1996 Diploma, Japanese Language and Society, Sheffield University, Sheffield, United Kingdom

Board Certifications

6/2008 American Board of Radiology

Experience/Service

Academic Appointments

Assistant Professor, Department of Radiation Physics - Patient Care (Tenure Track), Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2011-present
Assistant Professor, Department of Radiation Physics - Patient Care (Non-tenure track), Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2010-8/2011
Associate Member, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2010-10/2011
Assistant Professor, Radiation Oncology, Harvard Medical School, Boston, MA, 8/2007-6/2010
Instructor, Radiation Oncology, Harvard Medical School, Boston, MA, 2/2004-8/2007
Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2002-2/2004

Administrative Appointments/Responsibilities

Director, Clinical Physics, Brigham & Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, 1/2008-6/2010
Staff Physicist, Brigham & Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, 2/2004-12/2007

Other Appointments/Responsibilities

X-Ray Systems Specialist (Digital Radiography R&D), Canon Inc., Utsunomiya, Japan, 3/1999-12/2001
Business Consultant and Office Manager, Asia Advisory Service, Tokyo, Japan, 9/1997-3/1999
Research Engineer (Cone-Beam CT), Sony, Inc., Tokyo, Japan, 9/1996-7/1997
Mental and Physical Disability, Residential Social Worker, London, United Kingdom, 1988-1995

Institutional Committee Activities

Member, The University of Texas MD Anderson Cancer Center Small Animal Imaging Facility Internal Review Board, 2016-present
Member, OneConnect (EPIC) SuperUser (go-live team), 11/2015-present
Co-Leader, Center for Radiation Oncology Research Radiomics Infrastructure Project, 2015-present
Member, Search Committee for tenure-track faculty position in Radiation Physics, 2015
Member, U19 Steering Committee, Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy, 9/2014-present
Member, The University of Texas MD Anderson Africa Committee, 2014-present
Steering Committee Member, GSBS Medical Physics Program, 9/2013-9/2016
Admissions Committee Member, GSBS Medical Physics Program, 9/2013-9/2016
Member, Search Committee for Research Faculty position in Imaging Physics, 7/2012-12/2012
Member, The University of Texas MD Anderson Faculty Senate Research Affairs Committee, 11/2011-2014
Member, The University of Texas MD Anderson Faculty Senate Education Committee, 11/2011-2014
Faculty Senator, The University of Texas MD Anderson Faculty Senate, 2011-2014
Member, Leadership Training Admissions, Dana-Farber Cancer Institute, 2009-2010
Member, Clinical Operations Committee, Brigham & Women's/Dana-Farber Cancer Center, 2008-2010
Member, Quality Improvement Committee, Brigham & Women's/Dana Farber Cancer Center, 2008-2010
Co-Director, Harvard Medical Physics Residency Setup and Operations Committee, 2008-2010
Member, American Disability Act Committee, Brigham & Women's/Dana-Farber Cancer Institute, 2008-2009

Professional Memberships

American Association of Physicists in Medicine
Equipment Donation Subcommittee, 2016-present
SWAAPM Mock Board Exam Examiner, 2011-present
Imaging for Treatment Verification Work Group, 2009-present
Member, 2000-present
ASTRO
International Education Subcommittee, 2015-present
Member, 2008-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Sandulache VC, Chen Y, Skinner HD, Lu T, Feng L, Court LE, Myers JN, Meyn RE, Fuller CD, Bankson JA, Lai SY. Acute tumor lactate perturbations as a biomarker of genotoxic stress: development of a biochemical model. Mol Cancer Ther. e-Pub 9/16/2015. PMID: 26376962.
2. Fave X, Cook M, Frederick A, Zhang L, Yang J, Fried D, Stingo F, Court L. Preliminary investigation into sources of uncertainty in quantitative imaging features. Comput Med Imaging Graph 44:54-61, 9/2015. e-Pub 5/5/2015. PMID: 26004695.
3. Rubinstein AE, Liao Z, Melancon AD, Guindani M, Followill DS, Tailor RC, Hazle JD, Court LE. Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice. Medical Physics 42(9):5510, 9/2015. PMID: 26328998.
4. Ebe K, Sugimoto S, Utsunomiya S, Kagamu H, Aoyama H, Court L, Tokuyama K, Baba R, Ogihara Y, Ichikawa K, Toyama J. Development of a video image-based QA system for the positional accuracy of dynamic tumor tracking irradiation in the Vero4DRT system. Medical Physics 42(8):4745, 8/2015. PMID: 26233202.
5. Fried DV, Mawlawi O, Zhang L, Fave X, Zhou S, Ibbott G, Liao Z, Court LE. Stage III Non-Small Cell Lung Cancer: Prognostic Value of FDG PET Quantitative Imaging Features Combined with Clinical Prognostic Factors. Radiology. e-Pub 7/2015. PMID: 26176655.
6. Mackin D, Fave X, Zhang L, Fried D, Yang J, Taylor B, Rodriguez-Rivera E, Dodge C, Jones AK, Court L. Measuring Computed Tomography Scanner Variability of Radiomics Features. Invest Radiol 50(11). e-Pub 6/2015. PMID: 26115366.
7. Scarboro SB, Cody D, Alvarez P, Followill D, Court L, Stingo FC, Zhang D, McNitt-Gray M, Kry SF. Characterization of the nanoDot OSLD dosimeter in CT. Medical Physics 42(4):1797, 4/2015. PMCID: PMC4368592.
8. Zhang Y, Yang J, Zhang L, Court LE, Gao S, Balter PA, Dong L. Digital Reconstruction of High-Quality Daily 4D Cone-Beam CT Images Using Prior Knowledge of Anatomy and Respiratory Motion. Comput Med Imaging Graph 40:30-8, 3/2015. e-Pub 10/2014. PMID: 25467806.
9. Zhang L, Fried DV, Fave XJ, Hunter LA, Yang J, Court LE. IBEX: an open infrastructure software platform to facilitate collaborative work in radiomics. Medical Physics 42(3):1341-53, 3/2015. PMID: 25735289.
10. Mohamed AS, Ruangskul MN, Awan MJ, Baron CA, Kalpathy-Cramer J, Castillo R, Castillo E, Guerrero TM, Kocak-Uzel E, Yang J, Court LE, Kantor ME, Gunn GB, Colen RR, Frank SJ, Garden AS, Rosenthal DI, Fuller CD. Quality assurance assessment of diagnostic and radiation therapy-simulation CT image registration for head and neck radiation therapy: anatomic region of interest-based comparison of rigid and deformable algorithms. Radiology 274(3):752-63, 3/2015. e-Pub 11/2014. PMCID: PMC4358813.
11. Ngwa W, Sajo E, Ngoma T, Bortfeld T, Gierga D, White KB, Akinwande B, Enwerem-Bromson MM, Teboh Forbang R, Winningham TA, Court LE, Odedina FT, Wu R, Makrigiorgos M, Nguyen PL. Potential for information and communication technologies to catalyze global collaborations in radiation oncology. Int J Radiat Oncol Biol Phys 91(2):444-7, 2/2015. PMID: 25636767.
12. Martin R, Rubinstein A, Ahmad M, Court L, Pan T. Evaluation of intrinsic respiratory signal determination methods for 4D CBCT adapted for mice. Medical Physics 42(1):154-64, 1/2015. PMID: 25563256.
13. McCarroll RE, Rubinstein AE, Kingsley CV, Yang J, Yang P, Court LE. 3D-Printed Small-Animal Immobilizer for Use in Preclinical Radiotherapy. J Am Assoc Lab Anim Sci 54(5):545-8, 2015. PMCID: PMC4587623.
14. Baron C, Awan MJ, Mohamed ASR, Akel I, Rosenthal DI, Gunn GB, Garden AS, Dyer BA, Court L, Sevak PR, Kocak-Uzel E, Fuller CD. Estimation of daily interfractional larynx residual setup error after isocentric alignment for head and neck radiotherapy: quality assurance implications for target volume and organs-at-risk margination using daily CT on-rails imaging. Journal of Applied Clinical Medical Physics 16(1):159-169, 2015.
15. Zhang Y, Nowicka A, Solley TN, Wei C, Parikh A, Court L, Burks JK, Andreeff M, Woodward WA, Dadbin A, Kolonin MG, Lu KH, Klopp AH. Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers. PLoS One 10(8):e0136361, 2015. e-Pub 8/28/2015. PMID: 26317219.

Abstracts

1. Niedzielski J, Yang J, Stingo F, Krafft S, Martel M, Briere T, Mohan R, Court L. A Novel Method to Objectively Quantify Normal Tissue Toxicity in the Esophagus, AAPM 2015 Anaheim, California. Medical Physics 42(6):3547, 6/2015. PMID: 26128573.
2. Fave X, Fried D, Zhang L, Yang J, Balter P, Followill D, Gomez D, Jones A, Stingo F, Court L. A Phantom Study to Assess the Variability in Radiomics Features Extracted From Cone-Beam CT Images, AAPM 2015 Anaheim, California. Medical Physics 42(6):3214, 6/2015. PMID: 26127193.
3. Faught JT, Johnson J, Stingo F, Kry S, Court L, Balter P, Followill D. An FMEA Survey of Intensity Modulated Radiation Therapy (IMRT) Step and Shoot Dose Delivery Failure Modes, AAPM 2015 Anaheim, California. Medical Physics 42(6):3355, 6/2015. PMID: 26127770.
4. Zhou R, Yang J, Pan T, Milgrom S, Pinnix C, Shi A, Yang J, Liu Y, Nguyen Q, Gomez D, Dabaja B, Balter P, Court L, Liao Z. Atlas Development for Cardiac Automatic Contouring Using Multi-Atlas Segmentation, AAPM 2015 Anaheim, California. Medical Physics 42(6):3294, 6/2015. PMID: 26127520.
5. Faught JT, Balter P, Johnson J, Kry S, Court L, Stingo F, Followill D. Clinical Impact of IMRT Failure Modes at Or Near TG-142 Tolerance Criteria Levels. Medical Physics 42(6):3372, 6/2015. PMID: 26127844.
6. Kisling K, Court L, Kirsner S, Nelson C. Dose Calculation Accuracy with a Standard Beam Model for Extended SSD Treatments, AAPM 2015 Anaheim, California. Medical Physics 42(6):3396, 6/2015. PMID: 26127939.
7. Wang J, Yang J, Marshall S, Wen Z, Court L, Ibbott G. Dose Distribution Differences Caused by System Related Geometric Distortion in MRI-Guided Radiation Treatment System, AAPM 2015 Anaheim, California. Medical Physics 42(6):3312, 6/2015. PMID: 26127597.
8. Sorensen J, Duran C, Stingo F, Wei W, Rao A, Zhang L, Court L, Erasmus J, Godoy M. Dual-Energy Chest CT: The Effects of Virtual Monochromatic Reconstructions On Texture Analysis Features, AAPM 2015 Anaheim, California. Medical Physics 42(6):3214, 6/2015. PMID: 26127194.
9. Yang J, Balter P, Court L. Evaluation of Automatic Segmentation of Critical Structures for Head-And-Neck and Thoracic Radiotherapy Planning, AAPM 2015 Anaheim, California. Medical Physics 42(6):3591, 6/2015. PMID: 26128823.
10. Wang J, Yang J, Hwang K, Wen Z, Court L, Ibbott G. Evaluation of Residual Geometric Distortion in MRI for Treatment Planning, AAPM 2015 Anaheim, California. Medical Physics 42(6):3318, 6/2015. PMID: 26127618.
11. Krafft S, Briere T, Court L, Martel M. Normal Lung CT Texture Features Improve Predictive Models for Radiation Pneumonitis, AAPM 2015 Anaheim, California. Medical Physics 42(6):3602, 6/2015. PMID: 26128886.
12. Aristophanous M, Court L. Setup Uncertainties in the Mediastinum Area for IMRT Treatment of Lymphoma Patients, AAPM 2015 Anaheim, California. Medical Physics 42(6):3638, 6/2015. PMID: 26129096.
13. Yang J, Zhang L, Zhang Y, Dong L, Balter P, Court L. Solving the Chinese Postman Problem for Effective Contour Deformation, AAPM 2015 Anaheim, California. Medical Physics 42(6):3289, 6/2015. PMID: 26127500.
14. Zhang L, Fried D, Fave X, Mackin D, Yang J, Court L. The Importance of Appropriate Image Preprocessing to Augment the Information of Radiomics Image Features, AAPM 2015 Anaheim, California. Medical Physics 42(6):3326, 6/2015. PMID: 26127650.
15. Mackin D, Zhang L, Fave X, Fried D, Yang J, Taylor B, Rodriguez-Rivera E, Dodge C, Jones A, Court L. Toward Understanding the Robustness of Radiomics Features in CT, AAPM 2015 Anaheim, California. Medical Physics 42(6):3214, 6/2015. PMID: 26127192.
16. McInnis M, Taylor P, Poenisch F, Court L, Guindani M, Followill D. Uncertainties in Treatment Planning for IROC-Houston Proton Phantom QA Program Due to Variable CT Technique and Proton Energy, AAPM 2015 Anaheim, California. Medical Physics 42(6):3515, 6/2015. PMID: 26128437.
17. Ingram W, Yang J, Beadle B, Rao A, Wendt R, Court L. Virtual Endoscope Tracking for Endoscopy-CT Image Registration, AAPM 2015 Anaheim, California. Medical Physics 42(6):3655, 6/2015. PMID: 26129163.
18. Fave X, Fried D, Zhang L, Yang J, Balter P, Followill D, Gomez D, Jones A, Stingo F, Court L. Volume-Dependence of Quantitative Imaging Features From CT and CE-CT Images of NSCLC, AAPM 2015 Anaheim, California. Medical Physics 42(6):3321, 6/2015. PMID: 26127632.

Book Chapters

1. Court LE, Balter P and Mohan R. Principles of IMRT. In: Intensity-Modulated Radiation Therapy. Ed(s) Y Nishimura, R Komaki. Springer: Japan, 15-42, e-Book 2015. ISBN: 978-4-431-55485-1.
 

Other

1. Proceeding. Yamazaki T, Court L, Kameshima R.  Sensor gain and noise requirements for fluoroscopic applications.  Proc. SPIE 4320 489-500, 2001. .
2. Proceeding. Watanabe M, Mochizuki C, Kameshima T, Yamazaki T, Court L, Hayashida S, Morishita M, Ohta S. Development and evaluation of a portable amorphous silicon flat panel x-ray detector. Proc. SPIE 4320, 103-114, 2001.

Grant & Contract Support

Title: Development of a Multiparametric Predictor for Radiation-Induced Lung Damage after Lung Cancer Therapy
Funding Source: Sister Instition Network Fund
Role: Co-Investigator
Principal Investigator: Lin
Duration: 1/1/2016 - 12/31/2018
 
Title: Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Core A - Administrative
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Radhe Mohan/Thomas DeLaney
Duration: 9/1/2015 - 8/31/2019
 
Title: Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Project 3 - Assessing accuracy of proton therapy and understanding the impact of physical and biophysical factors on its outcomes
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Radhe Mohan/Thomas DeLaney
Duration: 9/1/2015 - 8/31/2019
 
Title: Predicting Radiation-Induced Cord Myelopathy Using a Molecular Imaging Readout of Retrograde Axonal Transport
Funding Source: Center for Radiation Oncology Research
Role: Co-Principal Investigator
Principal Investigator: Dawid Schellingerhout
Duration: 9/1/2015 - 8/31/2016
 
Title: A preclinical study investigating the impact of a magnetic field on radiation-induced toxicity
Funding Source: Elekta
Role: Principal Investigator
Duration: 9/1/2014 - 8/31/2016
 
Title: Tumor mutation status will predict metabolic response to metformin in NSCLC
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Skinner
Duration: 8/5/2014 - 7/31/2016
 
Title: Development of upright radiation therapy treatments
Funding Source: Varian Medical Systems
Role: Principal Investigator
Duration: 7/1/2014 - 6/30/2017
 
Title: Use of the Truebeam to take CT images of patients in a seated position for treatment planning purposes
Funding Source: Varian Medical Systems
Role: Principal Investigator
Duration: 2/1/2013 - 1/31/2016
 
Title: Advanced volumetric imaging and adaptive radiotherapy for detecting and correcting for inter-fractional changes
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Balter
Duration: 7/1/2011 - 12/30/2016
 
Title: Quality Assurance Core
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 5/1/2011 - 12/30/2016

Last updated: 7/11/2016