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Mariana Chavez Mac Gregor, MD, MSC

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2004 Netherlands Institute of Health and Sciences, Rotterdam, Netherlands, MSc, Clinical Epidemiology
2003 Medical School at Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, MD, Medicine

Postgraduate Training

7/2008-6/2011 Clinical Fellowship, Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2005-6/2008 Clinical Residency, Internal Medicine, Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO

Honors and Awards

2011 Achievement in Clinical Research Award, The Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center
2011 ASCO Cancer Foundation Merit Award, The Breast Cancer Symposium
2011 SWOG Young Investigator, SWOG
2010 Allison and Brian Grove Endowed Fellowship for Breast Medical Oncology, M.D. Anderson Cancer Center
2010 ASCO Cancer Foundation Merit Award, The Breast Cancer Symposium
2010 Selected for participation at the AACR/ASCO Methods in Clinical Cancer Research Workshop, Vail, Colorado
2009 AACR Minority Scholar, Susan G. Komen for the Cure
2009 Allison and Brian Grove Endowed Fellowship for Breast Medical Oncology, M.D. Anderson Cancer Center
2009 ASCO Cancer Foundation Merit Award, The Breast Cancer Symposium
2009 ASCO Merit Award
2008 Allison and Brian Grove Endowed Fellowship for Breast Medical Oncology, M.D. Anderson Cancer Center
2008 Kipnis-Daughaday Teaching Award, Washington University School of Medicine
2006 Best Poster Award, Mentors in Medicine Research Grant Scientific Symposium. Washington University School of Medicine
2006 Clinical Scientist Training and Research Program, Barnes Jewish Hospital, Washington University School of Medicine, St. Louis, MO.
2004 NIHES Award, Erasmus University Rotterdam, University of Amsterdam, Utrecht University, University of Nijmegen, National Institute of Public Health and Environment, Netherlands Cancer Institute
2003 Merit-based Academic CONACYT Scholarship, The National Council for Science and Technology in Mexico
2002 Achievement Medical Student Award, Universidad Nacional Autónoma de México
2001 Academic Distinction, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México

Professional Memberships

American Association for Cancer Research
Associate Member, 2009-present
American Society of Clinical Oncology
Associate Member, 2008-present
Mexican Society of Senology
Member, 2001-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Chavez-Macgregor M, Brown E, Lei X, Litton J, Meric-Bernstram F, Mettendorf E, Hernandez L, Valero V, Hortobagyi GN, Gonzalez-Angulo AM. Bisphosphonates and pathologic complete response to taxane- and anthracycline-based neoadjuvant chemotherapy in patients with breast cancer. Cancer 118(2):326-32, 1/2012. PMCID: PMC3158806.
2. Chavez-Macgregor M, Zhao H, Kroll M, Fang S, Zhang N, Hortobagyi GN, Buchholz TA, Shih YC, Giordano SH. Risk factors and incidence of thromboembolic events (TEEs) in older men and women with breast cancer. Ann Oncol 22(11):2394-402, 11/2011. PMID: 21393379.
3. Theriault RL, Litton JK, Mittendorf EA, Chen H, Meric-Bernstam F, Chavez-Macgregor M, Morrow PK, Woodward WA, Sahin A, Hortobagyi GN, Gonzalez-Angulo AM. Age and Survival Estimates in Patients Who Have Node-Negative T1ab Breast Cancer by Breast Cancer Subtype. Clin Breast Cancer 11(5):325-31, 10/2011. PMID: 21764391.
4. Chavez-Macgregor M, Zhao H, Fang S, Srokowski TP, Hortobagyi GN, Giordano SH. Complications associated with erythropoietin-stimulating agents in patients with metastatic breast cancer: A Surveillance, Epidemiology, and End Results-Medicare Study. Cancer 117(16):3641-9, 8/15/2011. e-Pub 2/24/2011. PMID: 21656514.
5. Raghav KP, Hernandez-Aya LF, Lei X, Gregor MC, Meric-Bernstam F, Buchholz TA, Sahin A, Do KA, Hortobagyi GN, Gonzalez-Angulo AM. Impact of low estrogen/progesterone receptor expression on survival outcomes in breast cancers previously classified as triple negative breast cancers. Cancer. e-Pub 8/11/2011. PMID: 21837669.
6. Melhem-Bertrandt A, Chavez-Macgregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, Sood AK, Conzen SD, Hortobagyi GN, Gonzalez-Angulo AM. Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol 29(19):2645-52, 7/1/2011. e-Pub 5/31/2011. PMCID: PMC3139371.
7. Hernandez-Aya LF, Chavez-Macgregor M, Lei X, Meric-Bernstam F, Buchholz TA, Hsu L, Sahin AA, Do KA, Valero V, Hortobagyi GN, Gonzalez-Angulo AM. Nodal status and clinical outcomes in a large cohort of patients with triple-negative breast cancer. J Clin Oncol 29(19):2628-34, 7/1/2011. e-Pub 5/23/2011. PMCID: PMC3139370.
8. Chavez-Macgregor M, Litton J, Chen H, Giordano SH, Hudis CA, Wolff AC, Valero V, Hortobagyi GN, Bondy ML, Gonzalez-Angulo AM. Pathologic complete response in breast cancer patients receiving anthracycline- and taxane-based neoadjuvant chemotherapy: evaluating the effect of race/ethnicity. Cancer 116(17):4168-77, 9/1/2010. PMCID: PMC2954673.
9. Aft R, Naughton M, Trinkaus K, Watson M, Ylagan L, Chavez-MacGregor M, Zhai J, Kuo S, Shannon W, Diemer K, Herrmann V, Dietz J, Ali A, Ellis M, Weiss P, Eberlein T, Ma C, Fracasso PM, Zoberi I, Taylor M, Gillanders W, Pluard T, Mortimer J, Weilbaecher K. Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncol 11(5):421-8, 5/2010. e-Pub 3/31/2010. PMID: 20362507.
10. Chavez-MacGregor M, van Gils CH, van der Schouw YT, Monninkhof E, van Noord PA, Peeters PH. Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women. Breast Cancer Res Treat 108(1):101-12, 3/2008. e-Pub 5/22/2007. PMCID: PMC2244694.
11. Ruvalcaba-Limón E, Robles-Vidal C, Poitevin-Chacón A, Chávez-Macgregor M, Gamboa-Vignolle C, Vilar-Compte D. Complications after breast cancer surgery in patients treated with concomitant preoperative chemoradiation: A case-control analysis. Breast Cancer Res Treat 95(2):147-52, 1/2006. e-Pub 12/1/2005. PMID: 16319989.
12. Chavez-Macgregor M, Aviles-Salas A, Green D, Fuentes-Alburo A, Gómez-Ruiz C, Aguayo A. Angiogenesis in the bone marrow of patients with breast cancer. Clin Cancer Res 11(15):5396-400, 8/1/2005. PMID: 16061853.
13. Chavez-MacGregor M, Elias SG, Onland-Moret NC, van der Schouw YT, Van Gils CH, Monninkhof E, Grobbee DE, Peeters PH. Postmenopausal breast cancer risk and cumulative number of menstrual cycles. Cancer Epidemiol Biomarkers Prev 14(4):799-804, 4/2005. PMID: 15824146.
14. Vidal-Millan S, Zeichner-Gancz I, Flores-Estrada D, Vela-Rodríguez BE, Vazquez-López MI, Robles-Vidal CD, Ramirez-Ugalde MT, Chávez-MacGregor M. A descriptive study of second primary malignancies associated to breast cancer in a mexican Hispanic population. Med Oncol 22(1):17-22, 2005. PMID: 15750192.
15. Ochoa-Carrillo FJ, Chávez-Mac Gregor M, Green-Renner D, Green-Schneeweiss L. [Paraneoplastic syndromes. Associated with lung cancer]. Cir Cir 71(2):150-61, Mar-Apr, 3/2003. PMID: 19764144.

Invited Articles
1. Chávez-MacGregor M, González-Angulo AM. Breast cancer, neoadjuvant chemotherapy and residual disease. Clin Transl Oncol 12(7):461-7, 7/2010. PMID: 20615822.
2. Chavez-MacGregor M, Gonzalez-Angulo AM. HER2-neu positivity in patients with small and node-negative breast cancer (pT1a,b,N0,M0): a high risk group? Clin Adv Hematol Oncol 7(9):591-8, 9/2009. PMID: 20020671.

Editorials
1. Chavez-Mac Gregor M. Bone Therapy in Breast Cancer: Why, when and what's next? The Breast Cancer Report 2(1), 2010.
2. Chavez-Mac Gregor M, Gonzalez-Angulo AM. Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. Breast Diseases: A Year Book Quarterly 21(2):142-3, 2010.
3. Chavez-Mac Gregor M, Weilbaecher K, Aft R. Bone marrow micrometastases: Is there a role for bisphosphonates? Breast Diseases: A Year Book Quarterly 19(4), 2009.
4. Chavez-Mac Gregor M, Gonzalez-Angulo AM. Poor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumors. Br J Cancer 100:680-83, 2009.

Book Chapters
1. Chavez Mac Gregor M, Hortobagyi GN. Metastatic breast cancer: A curable disease? In: Breast Cancer Today. In Press.
2. Chavez Mac Gregor M, Valero V, Hortobagyi GN. Locally advanced breast cancer. In: Advanced Therapy of Breast Diseases, 3rd. Ed(s) Babiera GV, Skoracki RJ, Esteva FJ, 855-876, 2012.
3. Chavez Mac Gregor M, Valero V. Metastatic breast cancer. In: The MD Anderson Manual of Medical Oncology, 679-710, 2011.
4. Chavez Mac Gregor M, Wildes TM. Breast cancer. In: Hematology and Oncology Subspeciality Consult, The Washington Manual Subspeciality Consult Series, 2nd, 189-203, 2008.

Last updated: 3/6/2013