Marie-Claude C Hofmann, Ph.D.

Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine

Present Title & Affiliation

Primary Appointment

Professor, Endocrine Neoplasia and Hormonal Disorders - Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1988	Dept. of Oncology University Hospital Zürich, Dept. of Biology University of Lausanne, Lausanne, CH, Cell Biology, Cancer Research, Ph.D
1977	Dept. of Biology University of Lausanne, Lausanne, CH, Biological Sciences, BS

Postgraduate Training

1991-1995	Postdoctoral Fellowship, NRSA, Developmental and Reproductive Biology, Sanford-Burnham Medical Discovery Institute, La Jolla, California
1990-1991	Postdoctoral Fellowship, Swiss Foundation for Medical and Biological Research, Developmental and Reproductive Biology, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
1989-1991	Postdoctoral Fellowship, Swiss National Foundation for Scientific Research, Developmental and Reproductive Biology, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA
1988-1989	Postdoctoral Fellowship, Cancer Research, Urology, University of Zürich Medical School, Zürich
1987-1988	Predoctoral Fellowship, Swiss Anti-Cancer League, Cancer Research, Hematology, University Hospital Zürich, Zürich
1983-1986	Predoctoral Fellowship, Swiss National Foundation for Scientific Research, Cancer Research, Hematology, University Hospital Zürich, Zürich

Experience & Service

Faculty Academic Appointments

Associate Professor, Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, 2006 - 2012

Associate Professor, Department of Biology, University of Dayton, Dayton, OH, 2001 - 2006

Assistant Professor, Department of Biology, University of Dayton, Dayton, OH, 1995 - 2001

Intramural Institutional Committee Activities

Member, Division of Internal Medicine Research Grand Rounds Committee, The University of Texas MD Anderson Cancer Center, 2021 - Present

Chair, Research Grand Rounds Committee, Division of Internal Medicine Research Grand Rounds Committee, The University of Texas MD Anderson Cancer Center, 2021 - 2023

Chair, Research Committee, Division of Internal Medicine, Research Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2019

Member, Human Stem Cell Research Committee, The University of Texas MD Anderson Cancer Center, 2015 - Present

Ad Hoc Member, Faculty Search Committees, Department of Endocrine Neoplasia & HD, The University of Texas MD Anderson Cancer Center, 2015 - Present

Member, IACUC, The University of Texas MD Anderson Cancer Center, 2015 - 2018

Deputy Chair, Research Committee, Division of Internal Medicine Research Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2017

Faculty, Teaching Faculty, GSBS Graduate Faculty, The University of Texas MD Anderson Cancer Center, 2014 - Present

Member, Departmental Executive Committee, Endocrine Neoplasia & HD, The University of Texas MD Anderson Cancer Center, 2014 - Present

Senator, Faculty Senate, The University of Texas MD Anderson Cancer Center, 2014 - 2019

Member, Faculty Academic Review Committee, The University of Texas MD Anderson Cancer Center, 2014 - 2018

Member, Division of Internal Medicine, Research Committee, The University of Texas MD Anderson Cancer Center, 2013 - Present

Member, Institutional Research Grant Program Committee (IRG), The University of Texas MD Anderson Cancer Center, 2012 - Present

Co-Chair, Departmental Seminar Series, Endocrine Neoplasia & HD, The University of Texas MD Anderson Cancer Center, 2012 - 2015

Member, Interviewer, Veterinary Medicine Admission Committee, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2011 - 2012

Member, Department Executive Committee, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2011 - 2012

Member, Safety Committee, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2011 - 2012

Chair, Division of Cell Biology and Anatomy, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2011 - 2012

Member, Physiology Search Committee, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2011

Member, Histology Search Committee, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2010

Member, Grievance Committee, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2009 - 2012

Member, Compliance Advisory Committee, University of Illinois at Urbana-Champaign, 2009 - 2012

Chair, Safety Committee, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2008 - 2012

Mentor (3 Faculties), Junior Faculty Mentoring Committee, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2007 - 2012

Member, Research Advisory Committee, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2007 - 2012

Member, Equal Employment Opportunities, Comparative Biosciences, University of Illinois at Urbana-Champaign, 2007 - 2012

Chair, Promotion & Tenure Committee, College of Arts & Sciences, University of Dayton, 2005 - 2006

Chair, Physiology/Cell Biology Search Committee, Biology Department, University of Dayton, 2004 - 2005

Member, Promotion & Tenure Committee, College of Arts & Sciences, University of Dayton, 2002 - 2005

Member, Graduate Curriculum Assessment, Biology Department, University of Dayton, 2001 - 2006

Member, Genetics Search Committee, Biology Department, University of Dayton, 2000 - 2001

Chair, Safety Committee, Biology Department, University of Dayton, 1999 - 2006

Member, Undergraduate Recruitment, Biology Department, University of Dayton, 1999 - 2006

Member, Safety Committee, University of Dayton, 1999 - 2006

Member, Interviewer, Joint Admission to U Cincinnati Medical School Program (JAMS) Selection Committee, University of Dayton, 1998 - 2005

Member, Central (Roesh) Library Committee, University of Dayton, 1998 - 2004

Chair, Physiology Search Committee, Biology Department, University of Dayton, 1998 - 2000

Member, Premedical/Predental Advisor, Premedical/Predental Faculty Committee, College of Arts & Sciences,, University of Dayton, 1997 - 2006

Member, Graduate Admissions, Biology Department, University of Dayton, 1997 - 1999

Chair, Distinguished Speaker Series, Biology Department, University of Dayton, 1997 - 1998

Chair, Library Liaison, Biology Department, University of Dayton, 1996 - 2006

Member, Graduate Coordinating and Assessment Committee, Department of Biology, University of Dayton, 1996 - 1997

Member, Undergraduate Curriculum Assessment, Biology Department, University of Dayton, 1995 - 2001

Member, Committee for the Development of Scientific Writing, Biology Department, University of Dayton, 1995 - 1997

Editorial Activities

Editor-In-Chief, Andrology, 2022 - 2024

Deputy Editor, Andrology, 2020 - 2022

Associate Editor, Andrology, 2019 - 2020

Associate Editor, Systems Biology in Reproductive Medicine, 2013 - Present

Editorial Board, International Journal of Developmental Biology, 2010 - Present

Editorial Board, Biology of Reproduction, 2005 - 2011

Honors & Awards

2024	Distinguished Andrologist Award, American Society of Andrology
2011	Killam Visiting Research Scholar Award, University of Calgary, AB, Canada
2010	Dr. Gordon and Mrs. Helen Kruger Research Excellence Award, College of Veterinary Medicine, University of Illinois at Urbana-Champaign
2007 - 2013	NIH Independent Scientist Award (K02 HD054607), NIH, NICHD
2005	George E. Nolan Award for Excellence in Research, University of Dayton, OH
1993 - 1995	National Research Service Award, National Cancer Institute, USA, NIH, NCI

Professional Memberships

International Thyroid Oncology Group

2022 - Present

American Association for Cancer Research

2020 - Present

American Thyroid Association

2015 - Present

Center for Reproductive Medicine, Texas Medical Center

2013 - Present

American Endocrine Society

2012 - Present

Texas Forum for Reproductive Sciences

2012 - Present

American Society of Andrology

2001 - Present

Gene Families and Isozymes Congress

2000 - Present

American Society for Bone and Mineral Research

2000 - 2006

Society for the Study of Reproduction

1998 - Present

Society for Developmental Biology

1996 - 2006

Council on Undergraduate Research

1996 - 2002

Sigma Xi

1995 - 2006

American Association for the Advancement of Science

1993 - Present

Selected Presentations & Talks

Local Presentations

2024. Targeting DNA damage recognition and repair in PDTC/ATC. Invited. Anaplastic Thyroid Cancer Research Retreat. Houston, TX, US.
2024. Role of p38/MAPK in Anaplastic Thyroid Cancer. Invited. Anaplastic Thyroid Cancer Research Day. Houston, TX, US.
2021. Generating a Phf21a-Floxed Mouse With a Novel DECAI CRISPR System to Study the Function of BHC80 in Development and Disease. Conference. 26th Texas Forum for Reproductive Sciences. Houston, Texas, US.
2019. Mechanisms of Resistance to Kinase Inhibitors in PTC/ATC: an Update. Conference. Aggressive Thyroid Cancers Program Grant Retreat. Houston, Texas, US.
2018. Role of BHC80/phf21a in the Spermatogonial Stem Cell Niche. Conference. Texas Forum for Reproductive Sciences. Houston, Texas, US.
2018. Mechanisms of resistance to kinase inhibitors in PDTC. Conference. Anaplastic Thyroid Cancer Research Retreat. Houston, Texas, US.
2017. BHC80 is a possible co-repressor of the Notch signaling pathway in mouse Sertoli cells. Conference. Texas Forum for Reproductive Sciences. Houston, Texas, US.
2016. Effect of cabozantinib on HGF/MET signaling in the testis. Conference. Texas Forum for Reproductive Sciences. Houston, Texas, US.
2016. ETV5, an ETS family Transcription Factor, Drives Proliferation and Epithelial-to Mesenchymal Transition in Papillary Thyroid Cancer. Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2016. Repression of GDNF transcription by Jag1/Notch signaling in Sertoli Cells. Conference. Texas Forum for Reproductive Sciences. Houston, Texas, US.
2016. Markers for Targeted Immunotherapy of Anaplastic Thyroid Cancer. Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2016. Long-term BRAF(V600E) inhibition results in a spontaneous KRAS(G12D) mutation and increased epithelial to mesenchymal transition (EMT) in papillary thyroid cancer cells (PTC). Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2015. Testis Stem Cells Signaling Pathways: A Readout for Toxicity of Tyrosine Kinase Inhibitors. Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2015. Effect of cabozantinib on HGF-MET signaling in the testis. Conference. Department of Internal Medicine Research Retreat. Houston, Texas, US.
2015. Acquired BRAF Inhibitor (BRAFi) Resistance Drives EMT in Papillary Thyroid Cancer (PTC). Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2015. Ablation of Rbpj rescues early pro-spermatogonia loss from ectopic activation of Notch signaling in mouse Sertoli cells. Conference. Texas Forum for Reproductive Sciences. Houston, Texas, US.
2015. Regulation of male germ line stem cell homeostasis. Conference. Texas Forum for the Reproductive Sciences. Houston, Texas, US.
2015. Physical interaction between spermatogonial stem cells and Sertoli cells is required for control of germ cell numbers. Conference. Texas Forum for Reproductive Sciences. Houston, Texas, US.
2014. Role of ETV5 Transcription Factor in Mouse Thyroid Development. Conference. Rice Undergraduate Research Symposium. Houston, Texas, US.
2014. Juxtacrine signaling in the testis stem cell niche. Conference. Center for Reproductive Medicine, Reproductive Health Research Day. Houston, Texas, US.
2013. Disruption of NOTCH signaling in Sertoli cells induces testicular germ cell hyperplasia. Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2013. Generation of capillary-like structures from mouse primary spermatogonial stem cells in defined three dimensional collagen gels. Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2013. Effects of activated estrogen receptors on acquired BRAF inhibitor resistance in papillary thyroid cancer (PTC). Conference. Division of Internal Medicine Research Retreat. Houston, Texas, US.
2013. The extracellular matrix protein NOV mediates vasculogenesis from mouse primary spermatogonial stem cells. Conference. Texas Forum for Reproductive Sciences (TFRS). Houston, Texas, US.

Regional Presentations

2014. Rbpj is required in Sertoli cells for proper stem cell regulation. Conference. Texas Forum for Reproductive Sciences (TFRS). San Antonio, Texas, US.
2012. MEHP impairs spermatogonial stem cell self-renewal. Conference. Illinois Symposium for Reproductive Sciences (ISRS 2012). Chicago, IL, US.
2011. MEHP reduces Fos expression in freshly isolated spermatogonial stem cells. Conference. Illinois Symposium in Reproductive Sciences (ISRS2011). Urbana, IL, US.
2011. Notch signaling in fetal Sertoli cells regulates gonocyte differentiation. Conference. Illinois Symposium in Reproductive Sciences (ISRS2011). Urbana, IL, US.
2011. In vitro differentiation of mouse primary spermatogonial stem cells into endothelial cells using growth factors and novel extracellular matrix proteins in a three-dimensional collagen gel. Conference. Illinois Symposium in Reproductive Sciences (ISRS2011). Urbana, IL, US.
2009. Isolation, characterization, and culture of canine spermatogonial stem cells. Conference. 30th Annual Northwestern Mini-Symposium on Reproductive Biology. Evanston, IL, US.
2009. The role of Notch signaling in the self-renewal and differentiation fate of mouse spermatogonial stem cells. Conference. 30th Annual Northwestern Mini-Symposium on Reproductive Biology. Evanston, IL, US.
2009. Isolation and characterization of canine spermatogonial stem cells. Conference. Institute for Genomic Biology Annual Symposium. Urbana, IL, US.
2009. The transcription factor Etv5 regulates Sertoli cell chemokines involved in maintaining spermatogonial stem cells in the niche. Conference. Institute for Genomic Biology Annual Symposium. Urbana, IL, US.
2008. Trans-differentiation of spermatogonial stem cells into reproductive and non-reproductive tissues of all three germ layers. Conference. 29th Annual Northwestern Mini-Symposium on Reproductive Biology. Evanston, US.
2008. Update on Stem Cell Research for Human Diseases. Conference. Lions Club. Champaign, IL, US.
2008. Phthalates decrease spermatogonial stem cell proliferation by altering GDNF signaling. Conference. 29th Annual Northwestern Mini-Symposium on Reproductive Biology. Evanston, IL, US.
2008. Identification of determinants involved in vascular trans-differentiation of spermatogonial stem cells. Conference. 21st Cell and Molecular Biology & Molecular Biophysics Symposium (MCB-MB). Urbana, IL, US.
2007. In Vitro Vasculogenesis in Tri-Dimensional Synthetic Niches. Conference. Institute for Genomic Biology. Urbana, IL, US.
2007. Regulation of p53 expression in spermatogonia by Notch1/Jagged1 in vitro. Conference. 28th Annual Northwestern Symposium on Reproductive Biology. Evanston, IL, US.
2007. Signaling Pathways within the Spermatogonial Stem Cell Niche. Conference. Biennial Reproductive Biology Retreat. Allerton, IL, US.
2006. Differential expression of molecular markers during osteogenesis in vivo. Conference. Ohio Academy of Sciences Annual Meeting. Dayton, OH, US.
2006. Effects of functionalized TiO2 nanoparticles on cellular apoptosis and formation of reactive oxygen species. Conference. Ohio Academy of Sciences Annual Meeting. Dayton, OH, US.
2006. Transplantation of immortalized germ cells. Conference. Ohio Academy of Sciences Annual Meeting. Dayton, OH, US.

National Presentations

2024. Characterization of RAS-mutant Anaplastic Thyroid Carcinoma (ATC). Conference. Chicago, IL, US.
2024. Site-Specific HRAS Q61R Activation Promotes Cell Proliferation via Activation of the PI3kinase/AKT/mTOR Pathway and TP53 Inactivation in Medullary Thyroid Cancer. Conference. Chicago, IL, US.
2024. Targeting the MAPK and DNA Repair Pathways in Poorly Differentiated and Anaplastic Thyroid Cancer Cells. Conference. Chicago, IL, US.
2024. Role of the ETV5/p38 Signaling Axis in BRAF-Mutated Anaplastic Thyroid Cancers. Conference. Chicago, IL, US.
2024. Anaplastic Thyroid Cancer Bone Metastasis: Mechanistic Insight From Mouse Models. Invited. Chicago, IL, US.
2024. Clinicopathological Features of Advanced, RAS-driven Differentiated Thyroid Carcinoma (DTC). Conference. Chicago, IL, US.
2024. Role of p38/MAPK in Aggressive Thyroid Cancers. Conference. Boston, MA, US.
2023. Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. Conference. Boston, MA, US.
2023. Role of LSD1 in Mouse Sertoli Cells. Conference. Boston, MA, US.
2022. Disruption of Cell Division by P34R Mutated RAC1. Conference. Washington, DC, US.
2021. RAC1 induces acquired dabrafenib resistance in association with anaplastic transformation in a papillary thyroid cancer patient. Conference. Virtual Meeting, US.
2021. Novel in Vitro Targeted Combination Therapies for Anaplastic Thyroid Cancer. Conference. Virtual Meeting, US.
2020. Increased donor DNA sequence integration by CRISPR/Cas9 in mice: Mechanistic insights. Conference. Virtual Meeting, US.
2020. Generation of a Phf21a-Floxed Mouse Using a Novel DECAI CRISPR Method. Conference. Virtual Meeting, US.
2019. Tissue-Specific Knockout of Genes in Mice Using DECAI CRISPR. Conference. Washington, DC, US.
2019. Revolutionizing the therapeutic landscape of a deadly disease. Conference. Chicago, IL, US.
2019. An acquired novel Rac1P34R mutation drives proliferation and actin reorganization in papillary thyroid cancer cells. Conference. Chicago, IL, US.
2019. How to Advocate for Ourselves. Conference. Chicago, IL, US.
2019. Regulation of blood-testis barrier proteins through NOTCH non-canonical pathways. Conference. Chicago, IL, US.
2019. Preclinical Modeling of BRAF Inhibitor Resistance Mechanisms in Thyroid Cancer. Conference. New Orleans, LA, US.
2018. Rapidly increasing knock-in efficiency of CRISPR in mice by using blastocysts as a testing model. Conference. San Diego, CA, US.
2018. Mechanisms of Resistance to Kinase Inhibitors in PTC and ATC. Conference. Washington, DC, US.
2018. Novel Mechanisms of Resistance to Kinase Inhibitors in PTC. Conference. Rockville, MD, US.
2018. BHC80 is a Co-Repressor of NOTCH/RBPJ Signaling in Sertoli Cells. Conference. New Orleans, LA, US.
2018. From Post-Doc to Assistant Professor. Conference. Portland, OR, US.
2018. Doing Basic Research in a Clinical World. Conference. Portland, OR, US.
2017. The Chromatin Modifier Cofactor BHC80 is a Downregulator of Notch Signaling in Sertoli cells. Conference. Kona, HI, US.
2017. Regulation of Cyp26B1 expression in the spermatogonial stem cell niche. Conference. Miami, FL, US.
2017. The chromatin modifier BHC80 is a downregulator of NOTCH signaling in the mammalian testis. Conference. Miami, FL, US.
2017. Regulation of Cyp25B1 expression in the mammalian testis. Conference. Miami, FL, US.
2016. Long-term BRAF(V600E) inhibition results in a spontaneous KRAS(G12D) mutation and increased epithelial to mesenchymal transition (EMT) in papillary thyroid cancer cells (PTC). Conference. New Orleans, LA, US.
2016. The JAG1/NOTCH canonical effectors HES1 and HEY1 bind to the GDNF proximal promoter to repress its transcription in Sertoli cells. Conference. New Orleans, LA, US.
2016. Activation of NOTCH signaling in Sertoli cells in vivo is dependent upon the presence of germ cells. Conference. New Orleans, LA, US.
2016. Using Immunodetection Techniques for Assessing Male Fertility. Conference. New Orleans, LA, US.
2016. Ablation of Rbpj rescues early pro-spermatogonia loss from ectopic activation of Notch signaling in mouse Sertoli cells. Conference. New Orleans, LA, US.
2015. A Spontaneous KRAS(G12D) Mutation Following Long-Term Vemurafenib Treatment Drives Acquired BRAF Inhibitor (BRAFi) Resistance in a BRAF(V600E) PTC Cell Line. Conference. Orlando, FL, US.
2015. ETV5, an Ets Transcription Factor, is a Marker for Thyroid Cancer Progression. Conference. Orlando, FL, US.
2015. NOTCH Signaling in Sertoli Cells. Conference. Salt Lake City, UT, UT, US.
2014. Improving Sperm Output in Oligospermia?. Conference. Grand Case.
2014. NOTCH signaling regulates the testis stem cell niche. Conference. New London, NH, US.
2014. Notch Signaling in the Male Germ Line Stem Cell Niche. Conference. Chicago, IL, US.
2012. Generation of capillary-like structures from mouse primary spermatogonial stem cells in defined three-dimensional collagen gels. Conference. State College, PA, US.
2012. Silver nanoparticles affect Leydig cell function in vivo. Conference. Houston, TX, US.
2012. Constitutive expression of activated NOTCH1 in Sertoli cells leads to a loss of GDNF and CYP26B1 expression, and premature gonocyte differentiation. Conference. Tucson, AZ, US.
2012. MEHP reduces maintenance and proliferation of primary spermatogonial stem cells in vitro. Conference. Tucson, AZ, US.
2012. Intravenous administration of silver nanoparticles in male mice alters Leydig cell function and increases serum testosterone, but does not perturb spermatogenesis. Conference. San Francisco, CA, US.
2011. Overactivation of Notch signaling in fetal Sertoli cells results in dysregulation of germ cells, which results in germ cell apoptosis and Sertoli-only phenotype. Conference. Portland, OR, US.
2011. Notch signaling in the postnatal male germ-line. Conference. Portland, OR, US.
2010. Characterization of Ubiquitin Carboxyl-terminal Hydrolase L1 in the Fate Determination of Spermatogonia. Conference. Milwaukee, WI, US.
2010. Differentiation of stem/progenitor spermatogonia into prostatic epithelium: direct or indirect?. Conference. Milwaukee, WI, US.
2010. Spermatogonial stem cell isolation, culture, and analysis in vitro. Conference. Houston, TX, US.
2010. Reporter mice for stem cell isolation. Conference. Houston, TX, US.
2010. MEHP decrease spermatogonial stem cell proliferation by altering GDNF signaling. Conference. Salt Lake City, UT, US.
2009. Differentiation of Spermatogonial Stem Cells into Capillaries. Conference. St Croix.
2009. Vascular trans-differentiation of spermatogonial stem cells. Conference. Philadelphia, PA, US.
2009. Phthalates decrease spermatogonial stem cell proliferation by altering GDNF signaling. Conference. Philadelphia, PA, US.
2008. Synthetic stem cell niche for in vitro spermatogonial stem cell culture. Conference. Philadelphia, PA, US.
2008. Signal Integration Within the Spermatogonial Stem Cell Niche. Conference. Kailua-Kona, HI, US.
2008. Regulation of the Spermatogonial Stem cell Niche. Conference. Albuquerque, NM, US.
2008. Silver nanoparticles disrupt GDNF signaling in male germ-line stem cells. Conference. Seattle, WA, US.
2007. Isolation and characterization of GFRa-1 positive spermatogonial stem cells in the immature mouse. Conference. Washington, DC, US.
2007. Neonatal role of Ets-related molecule (ERM) in spermatogonial stem cell (SSC) maintenance may involve SSC receptors for GDNF. Conference. Tampa, FL, US.
2007. Regulation of apoptosis in spermatogonial stem cells by Jagged1 and GDNF in vitro. Conference. Tampa, FL, US.
2007. Time course of spermatogonial stem cell loss in ERM knockout mice: critical neonatal effects of ERM. Conference. Tampa, FL, US.
2007. Ets-related molecule (ERM) and spermatogonial stem cell self-renewal. Conference. Keystone, CO, US.
2006. GDNF signals through Src-dependent and Src-independent mechanisms in male germ-line stem cells. Conference. Chicago, IL, US.
2006. Effects of Jagged1 and GDNF on mouse spermatogonial stem cells in vitro. Conference. Chicago, IL, US.
2006. Effect of silver nanoparticles on Src activity in C18-4 cells. Conference. San Diego, CA, US.
2005. A germ-line stem cell line as a model for evaluating the cytotoxicity of nanoparticles in vitro. Conference. New Orleans, LA, US.
2004. Influence of GDNF on Spermatogonial Stem Cells. Conference. Washington, DC, US.
2004. Influence of Glial Cell Line-Derived Neurotrophic Factor (GDNF) on Male Germ Line Stem Cells. Conference. New London, CT, US.
2003. Isolation of testicular stem cells; influence of glial cell line-derived neurotrophic factor in vitro. Conference. Baltimore, MD, US.
2002. Microarray analysis of GDNF-responsive genes in type A spermatogonia. Conference. St Thomas, VI.
2001. Immunomagnetic Isolation of Germ Cells. Conference. Charlottesville, VA, US.
2000. In vitro Culture Systems for Male Germ Cells. Conference. Washington, DC, US.
1995. Establishment of Murine Meiotic Germ Cell Lines and Their Use to Study Spermatogenesis in vitro. Conference. Raleigh, NC, US.

International Presentations

2023. Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. Conference. International Transgenic Technology Meeting. Houston, US.
2023. Resistance to Kinase Inhibitors in BRAF-Mutated Anaplastic Thyroid Cancer. Conference. Naples, IT.
2022. Dedifferentiation of a Human Papillary Thyroid Tumor into Aggressive Anaplastic Thyroid Cancer Upon Dabrafenib Treatment: Pleiotropic Roles of the Small GTPase RAC1. Conference. Montreal, CA.
2022. BRAF/MEK inhibitor combination therapy in BRAF V600E-mutated papillary thyroid carcinoma: Does the presence of a TERT promoter mutation influence therapeutic response?. Conference. Montreal, CA.
2022. Roles of BHC80/LSD1 in spermatogenesis. Conference. Nairobi, KE.
2020. Floxing Mice Using a Novel DECAI CRISPR System. Conference. Virtual Meeting, US.
2019. SED [Single strand Ended Double strand] DNA donors as an inexpensive, easy to make, and efficiently inserted, long CRISPR donor. Conference. Kobe, JP.
2018. An acquired novel RAC1(P34R) mutation drives BRAF-inhibitor resistance in a papillary thyroid cancer patient. Conference. Playa Portero, PR.
2017. Pembrolizumab added to Kinase Inhibitor (KI) therapy in Anaplastic Thyroid Carcinoma (ATC): A Single Cancer Center’s Experience. Conference. Victoria, CA.
2017. BRAF Mutant Papillary Thyroid Cancer Cells with Concurrent Mutations Along the KRAS-RAC1 Axis Develop Resistance to BRAF(V600E)-Inhibitors and Are Associated with Increases in EMT Markers. Conference. Victoria, CA.
2017. Circulating BRAFV600E cell-free DNA detected by droplet digital PCR (ddPCR) as a biomarker in the management of anaplastic thyroid carcinoma (ATC) patients. Conference. Victoria, CA.
2017. ETV5, an ETS family Transcription Factor, Drives Epithelial-to Mesenchymal Transition through expression of TWIST1 in Papillary Thyroid Cancer. Conference. Victoria, CA.
2016. Regulation of CYP26B1 expression in Sertoli cells. Conference. Rio Grande, PR.
2016. Regulation of GDNF expression by Sertoli cells. Conference. Saint Malo, FR.
2016. Rapamycin inhibits antidepressant effects of leucine in lipopolysaccharide-treated mice. Conference. Brighton, GB.
2015. Understanding Acquired Braf Inhibitor Resistance In Braf(V600e) Mutated Thyroid Cancers. Conference. Placencia, BZ.
2015. Regulation of the Testis Stem Cell Niche by NOTCH Signaling. Conference. Athens, GR.
2015. Regulation of GDNF Expression by NOTCH signaling. Conference. San Juan, PR.
2014. Regulation of Germ Line Stem Cell Homeostasis. Conference. Campinas, BR.
2014. Mechanisms Controlling the Male Germ Line Stem Cell Niche. Conference. Iguaçu Falls, BR.
2013. Regulation of GDNF signaling in the perinatal male germ cell niche. Conference. St John, AG.
2013. Effects of activated estrogen receptors on acquired BRAF inhibitor resistance in papillary thyroid cancer (PTC). Conference. San Juan, PR.
2013. Estrogens and Thyroid Cancer. Conference. Nairobi, KE.
2013. Regulation of the male germline stem cell niche. Conference. Hong Kong, CN.
2012. NOTCH signaling in perinatal Sertoli cells modulates germ cell fate. Conference. Rodney Bay, LC.
2012. Notch signaling in Sertoli cells controls early germ cell differentiation. Conference. Kyoto, JP.
2011. A role for Notch signaling at male germ cell meiosis?. Conference. Montreal, CA.
2011. Characterization and in-vitro propagation of canine stem/progenitor spermatogonia. Conference. Montreal, CA.
2011. The spermatogonial stem cell niche is not dependent on Leydig cells in the collared peccary (Tayassu tacaju). Conference. Montreal, CA.
2010. Role of the bHLH transcription factor HEYL in male germ cell meiosis. Conference. Providenciales, GB.
2010. Delta-like homolog I (Dlk1) is a novel marker for prepubertal Sertoli cells. Conference. Águas de São Pedro, BR.
2010. Investigation of Potential Specific Markers for Spermatogonial Stem Cells in the Nile Tilapia (Oreochromis niloticus). Conference. Águas de São Pedro, BR.
2010. Human spermatogonial stem cells. Conference. Copenhagen, DK.
2009. Molecular Mechanisms Regulating Spermatogonial Stem Cells Within their Niche. Conference. Aguas de Lindóia, BR.
2009. Alteration of Signaling Pathways in Spermatogonial Stem Cells by Environmental Toxicants. Conference. São Paulo, BR.
2009. Differentiation of Spermatogonial Stem Cells into Prostate and Other Somatic Tissues. Conference. São Paulo, BR.
2009. Regulation of Spermatogonial Stem Cells Homing and Retention. Conference. Giessen, DE.
2008. Toxicity of Silver Nanoparticles in Male Germ-line Stem Cells. Conference. St Maarten, NL.
2008. Spermatogonial Stem cells In and Out of Their Niche. Conference. Sao Paulo, BR.
2008. Regulation of the Spermatogonial Stem cell Niche. Conference. Budapest, HU.
2007. Role of Notch-1 Signaling in the Mammalian Male Germ Line. Conference. Tamarindo, CR.
2005. Signaling pathways in germ-lime stem cells. Conference. Asilomar Conference Grounds, US.
2004. Role of glial cell line-derived neurotrophic factor (GDNF) in germ-line stem cell fate. Conference. Montego Bay, JM.
2001. Isolation of murine testis stem cells based on cell surface phenotype. Conference. Punta Cana, DO.
2000. Characterization of Immortalized Germ Cells and Sertoli Cells Using the GFRα-Receptor Family of Proteins. Conference. Punta Cana, DO.
1992. The Use of Oncogenes to Immortalize Testicular Cells. Conference. Copenhagen, DK.

Formal Peers

2024. Genetic Mutations in Thyroid Cancers. Houston, Texas, US.
2023. Molecular Biology of Thyroid Cancer. Houston, Texas, US.
2023. Genetic Mutations in Thyroid Cancers. Houston, Texas, US.
2023. Novel Combination Therapies for Anaplastic Thyroid Cancer___ Preclinical Studies. Houston, Texas, US.
2023. Role of p38 in anaplastic thyroid cancers. Houston, Texas, US.
2022. Role of BHC80/LSD1 in spermatogenesis. Invited. Pullman, WA, US.
2022. Genetic Mutations in Thyroid Cancers. Visiting. Houston, TX, US.
2021. Resistance to Kinase Inhibitor Therapies in Thyroid Cancers. Invited. Oxford, OH, US.
2021. Genetic Mutations in Thyroid Cancers. Visiting. Houston, TX, US.
2021. Mechanisms of Resistance to Kinase Inhibitors in Anaplastic Thyroid Carcinoma. Visiting. Houston, TX, US.
2020. A Novel Acquired RAC1 (P34R) mutation induces ATP progression in a PTC patient. Invited. online meeting, OH, US.
2020. Acquired BRAF inhibitor resistance in a PTC patient: role of a RAC1 (P34R) mutation. Visiting. Houston, TX, US.
2020. Genetic Mutations in Thyroid Cancers. Visiting. Houston, TX, US.
2020. Cancer Treatments and Male Fertility. Visiting. Houston, TX, US.
2020. Role of the Epigenetic Reader BHC80 in Development and Disease. Visiting. Houston, TX, US.
2020. Studying the function of BHC80 in Sertoli cells: using a novel technique for floxing mice. Visiting. Houston, TX, US.
2019. Mechanisms of Resistance to Kinase Inhibitors in Anaplastic Thyroid Cancers. Invited. Houston, TX, US.
2019. Mechanisms of Resistance to Kinase Inhibitors in PTC/ATC: An Update. Visiting. Houston, TX, US.
2019. Acquired BRAF inhibitor resistance in a PTC patient: characterization of a RAC1 (P34R) mutation. Invited. Columbus, OH, US.
2018. Mechanisms of Resistance to Kinase Inhibitors in Thyroid Cancers. Visiting. Houston, TX, US.
2018. Molecular Biology of Differentiated Thyroid Cancers. Visiting. Houston, TX, US.
2018. Role of BHC80 Within the Spermatogonial Stem Cell Niche. Visiting. Houston, TX, US.
2018. Molecular Biology of Differentiated Thyroid Cancers. Visiting. Houston, TX, US.
2017. New Insights Into the Testicular Stem Cell Niche. Invited. Houston, TX, US.
2017. The Spermatogonial Stem Cell Niche. Visiting. Houston, TX, US.
2016. Notch Signaling in Sertoli Cells. Visiting. Houston, TX, US.
2015. Mechanisms of Drug Resistance in Papillary Thyroid Cancer. Invited. Lubbock, TX, US.
2015. Spermatogonial Stem Cell Homeostasis. Invited. Washington, DC, DC, US.
2014. Effects of Phthalates on Male Germ Line Stem Cells. Invited. Sao Paulo, SP, BR.
2014. NOTCH signaling in the male germ line stem cell niche. Invited. San Antonio, TX, US.
2012. Plasticity of Spermatogonial Stem Cells: Influence of the Extracellular Matrix. Visiting. Houston, TX, US.
2012. Cancer stem cells: Current Status and Evolving Complexities. Visiting. Houston, TX, US.
2012. Testis Stem Cells: An Alternate Source of Pluripotent Stem Cells for Tissue Engineering. Visiting. Houston, TX, US.
2011. Spermatogonial stem cells inside and out: intrinsic and extrinsic control of self-renewal and differentiation. Invited. Houston, TX, US.
2011. Toxicity of Silver Nanoparticles in Male Germ-line Stem Cells. Visiting. Calgary, CA.
2011. Spermatogonial stem cells for in vitro vasculogenesis. Invited. Calgary, CA.
2010. Stem cell models for vasculogenesis in 3D scaffolds. Invited. Urbana, IL, US.
2010. Spermatogonial Stem Cells For Blood Vessels Regeneration and Engineering. Invited. Urbana, IL, US.
2010. Using Spermatogonial Stem Cells for Tissue Regeneration. Visiting. Urbana, IL, US.
2009. Spermatogonial Stem Cells for Tissue Engineering. Invited. Belo Horizonte, Minas Gerais, BR.
2009. The Spermatogonial Stem Cell Niche. Invited. Urbana, IL, US.
2008. Reprogramming Spermatogonial Stem Cells for Capillary Engineering. Invited. Urbana, IL, US.
2008. Engineering the Spermatogonial Stem Cell Niche. Invited. Belo Horizonte, BR.
2007. Cellular Interactions Within the Spermatogonial Stem Cell Niche. Invited. Kennett Square, PA, US.
2007. The Fate of Spermatogonial Stem Cells. Visiting. Urbana, IL, US.
2007. Spermatogonial Stem Cell Niche and Plasticity. Visiting. Urbana, IL, US.
2006. Stem cell renewal and carcinogenesis. Visiting. Urbana, IL, US.
2006. Role of GDNF in spermatogonial stem cell fate. Invited. Washington, DC, US.
2006. Nanoparticles for the modulation of signaling pathways. Invited. Bethesda, MD, US.
2006. Spermatogonial stem cells. Invited. Urbana, IL, US.
2006. GDNF signaling in male germ-line stem cells. Invited. Houston, TX, US.
2005. Germ-line stem cells: are they potential targets for chemical toxicants?. Invited. Urbana, IL, US.
2004. GDNF acts through the activation of Src kinase in male germ line stem cells. Invited. Washington, DC, US.
2003. Self-renewal and differentiation of spermatogonial stem cells in vitro. Invited. Research Triangle Park, NC, US.
2002. Differentiation potential of murine testis stem cells in vitro. Invited. Bethesda, MD, US.
2001. Proliferation and Differentiation of Bone Marrow Osteogenic Cells. Invited. Washington, DC, US.
1999. In vitro Osteogenesis by Bone-Marrow-Derived Stem Cells. Invited. La Jolla, CA, US.
1999. Immortalization by Gene Transfection. Invited. Urbana, IL, US.
1996. Development of an in vitro Model for Mammalian Spermatogenesis and Testis Morphogenesis. Invited. Dayton, OH, US.
1993. Apoptosis and Spermatogenesis. Invited. Copenhagen, DK.
1992. A Mouse Model for Spermatogenesis in vitro. Invited. Zürich, CH.

Less

Grant & Contract Support

Date:	2026 - Present
Title:	ImpACT: Improving Treatment Strategies for Anaplastic Thyroid Cancer Through Integration of Novel Therapies and Assessment of Tumor Response
Funding Source:	NIH-NCI
Role:	P01 Co-Leader, Project 1 Principal Investigator, Core B Co-Leader

Date:	2026 - Present
Title:	Preclinical Evaluation of nsPFA as a Novel Modality for the Control of Anapastic Thyroid Cancer
Funding Source:	MDACC
Role:	PI

Date:	2025 - 2028
Title:	Preservation of Fertility in Male Cancer Patients Using Pharmacological Approaches
Funding Source:	CPRIT
Role:	PI

Date:	2024 - Present
Title:	Exploring nsPFA ablation therapy for anaplastic thyroid cancer
Funding Source:	Philanthropy
Role:	Co-PI

Date:	2024 - 2029
Title:	Hormonal Regulation of Sertoli Cell Maturation (subcontract)
Funding Source:	NIH-NICHD
Role:	Co-I
ID:	R01HD010808

Date:	2024 - 2029
Title:	Identification of an immune-related prognostic signature in anaplastic thyroid cancer
Funding Source:	NIH/NCI
Role:	Co-I

Date:	2024 - 2016
Title:	Role of histone demethylase RIOX1 in DNA repair and response to therapy in medullary thyroid cancer
Funding Source:	NIH/NCI
Role:	Co-I

Date:	2024 - 2029
Title:	Role of p38/MAPK14 in aggressive thyroid cancers
Funding Source:	NIH/NCI
Role:	Principal Investigator-MDACC

Date:	2024 - Present
Title:	A Concept Study for Treating Anaplastic Thyroid with Radio-Immunotherapy
Funding Source:	Philanthropy
Role:	Co-PI

Date:	2023 - 2024
Title:	Genomic Instability in Tumors Resistant to Targeted Therapies
Funding Source:	Elsa Pardee Foundation
Role:	PI

Date:	2023 - 2028
Title:	ATC: gender disparity, immune landscape and targeted immunotherapy approaches
Funding Source:	NIH/NCI
Role:	Co-I

Date:	2023 - 2028
Title:	Role of p38/MAPK14 in aggressive thyroid cancers
Funding Source:	NIH/NCI
Role:	PI

Date:	2023 - 2026
Title:	VD—PTC Research Endocrine. Harnessing CAFs for Therapy
Funding Source:	Philanthropy
Role:	PI

Date:	2023 - 2026
Title:	RA220221 Novel combination therapies for anaplastic thyroid cancer
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	PI
ID:	RA220221

Date:	2023 - 2026
Title:	RA220228 Targeting histone demethylase RIOX1 in medullary thyroid cancer
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	Co-I

Date:	2023 - 2028
Title:	Hormonal Regulation of Sertoli Cell Maturation (subcontract)
Funding Source:	NHI NICHD
Role:	Co-I

Date:	2023 - 2025
Title:	Role of the LSD1/BHC80 Complex in Sertoli Cells
Funding Source:	NHI NICHD
Role:	PI

Date:	2022 - 2024
Title:	Novel targeted combination treatment strategies for aggressive thyroid cancers
Funding Source:	NIH/NCI
Role:	Co-PI

Date:	2021 - 2022
Title:	Overcoming drug resistance in anaplastic thyroid cancer
Funding Source:	American Association for Cancer Research (AACR)
Role:	PI

Date:	2021 - 2024
Title:	Molecular Mechanism of Drug Resistance in Aggressive Thyroid Cancer
Funding Source:	Welch Foundation
Role:	PI

Date:	2021 - 2022
Title:	Effective treatment strategies using novel combination therapies in aggressive thyroid cancers
Funding Source:	Elsa Pardee Foundation
Role:	PI

Date:	2021 - Present
Title:	Targeted Therapy Combined with Pembrolizumab in Anaplastic Thyroid Cancer: Predicting and Monitoring Treatment Response
Funding Source:	GATEWAY FOR CANCER RESEARCH
Role:	Co-I

Date:	2021 - 2023
Title:	Epigenetic Regulation of Testicular Cancers
Funding Source:	NIH/NCI
Role:	Principal Investigator-MDACC

Date:	2020 - Present
Title:	The Anaplastic Thyroid Cancer Multidisciplinary Petrick Research Funds
Funding Source:	Petrick/MDA funds
Role:	Co-Program Leader

Date:	2020 - 2022
Title:	Modulation of the Anaplastic Thyroid Cancer Environment
Funding Source:	MDACC IRG
Role:	PI

Date:	2020 - 2025
Title:	Pleiotropic roles of RBPJ in Sertoli cells
Funding Source:	NIH/NICHD
Role:	Principal Investigator-MDACC

Date:	2020 - 2025
Title:	Mechanisms of thyroid cancer progression
Funding Source:	NIH/NCI
Role:	Principal Investigator-MDACC

Date:	2020 - 2022
Title:	Role of BHC80 in Spermatogenesis
Funding Source:	NIH/NICHD
Role:	PI
ID:	R03 HD101650-01

Date:	2020 - 2022
Title:	Modulation of the Anaplastic Thyroid Cancer Tumor Microenvironment
Funding Source:	MD Anderson Cancer Center IRG
Role:	PI

Date:	2019 - 2024
Title:	OSU-MDA Thyroid Cancer SPORE- Project 4
Funding Source:	NIH/NCI
Role:	Co-PI

Date:	2019 - 2024
Title:	Retinoic Acid, a Candidate for Male Fertility Preservation After Gonadotoxic Exposure
Funding Source:	NIH NICHD
Role:	Co-I

Date:	2019 - 2014
Title:	Molecular Regulation of the Perinatal and Adult Male Germ Cell Environment
Funding Source:	NIH/NICHD
Role:	PI

Date:	2019 - 2010
Title:	Retinoic Acid, a Candidate for Male Fertility Preservation After Cancer Treatment
Funding Source:	MDACC IRG
Role:	Co-I

Date:	2018 - 2023
Title:	Retinoic Acid, a Candidate for Male Fertility Preservation After Gonadotoxic Exposure
Funding Source:	NIH/NICHD
Role:	Co-I

Date:	2018 - 2023
Title:	Mechanisms of resistance to combination therapies in anaplastic thyroid cancer
Funding Source:	NIH/NCI
Role:	PI
ID:	1R01CA233474-01

Date:	2018 - 2020
Title:	OSU/MDA Thyroid Cancer SPORE Project 4: Mechanisms of resistance to combination therapies in anaplastic thyroid cancer
Funding Source:	MDACC Bridge Funding
Role:	Co-PI

Date:	2018 - 2023
Title:	The Ohio State University and MD Anderson Cancer Center Thyroid Center SPORE
Funding Source:	Ohio State University
Role:	Co-Program Leader
ID:	2 P50 CA168505-06

Date:	2018 - 2019
Title:	Novel Alternative Pathways and Mutational Hotspots in Papillary Thyroid Cancer with Acquired Resistance to BRAF Inhibitors
Funding Source:	American Thyroid Association
Role:	Mentor

Date:	2018 - 2020
Title:	Role of BHC80 in Sertoli cells
Funding Source:	NIH-NICHD
Role:	PI
ID:	1R21HD096557-01

Date:	2018 - 2019
Title:	Retinoic Acid, a Candidate for Male Fertility Preservation After Cancer Treatment
Funding Source:	MDACC IRG
Role:	Co-I

Date:	2018 - 2021
Title:	MRP: Improving Treatment Strategies for Anaplastic Thyroid Cancer Through Integration of Novel Therapies and Assessment of Treatment Response
Funding Source:	UTMDACC
Role:	Co-PI

Date:	2018 - 2023
Title:	Role of PAK in Thyroid Cancer (Subcontract)
Funding Source:	Ohio State University / NIH / NCI
Role:	Co-I
ID:	1R01CA227847-01

Date:	2018 - 2020
Title:	Novel Genetic and Epigenetic Drivers of Acquired BRAF Inhibitor Resistance in Papillary Thyroid Cancer
Funding Source:	NIH/NCI
Role:	Co-I

Date:	2018 - 2021
Title:	Improved Therapies for Anaplastic Thyroid Cancer
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI

Date:	2018 - Present
Title:	Pharmacodynamic study of vemurafenib in the neoadjuvant setting in patients with locally advanced thyroid cancer
Funding Source:	Genentech
Role:	Collaborator
ID:	PA12-0494

Date:	2018 - 2018
Title:	Retinoic Acid, a Candidate for Male Fertility Preservation After Cancer Treatment
Funding Source:	MDACC IRG
Role:	Co-I

Date:	2017 - 2022
Title:	Mechanisms of resistance to targeted therapies in papillary thyroid cancer
Funding Source:	NIH/NCI
Role:	PI

Date:	2017 - 2018
Title:	Novel pathways to escape targeted therapies in thyroid cancers
Funding Source:	Elsa Pardee Foundation
Role:	PI

Date:	2017 - 2020
Title:	MRP: Improving Treatment Strategies for Anaplastic Thyroid Cancer Through Integration of Novel Therapies and Assessment of Treatment Response
Funding Source:	MDA
Role:	Co-PI

Date:	2017 - 2010
Title:	Preventing Cancer Therapy Toxicities with an Early Stress Reduction Intervention
Funding Source:	Susan G. Komen Breast Cancer Foundation
Role:	Collaborator

Date:	2017 - 2018
Title:	Novel Alternative Pathways and Mutational Hotspots in Papillary Thyroid Cancer with Acquired Resistance to BRAF Inhibitors
Funding Source:	American Thyroid Association
Role:	Collaborator
ID:	ATA-2017-054.R1

Date:	2017 - 2018
Title:	Role of ETS transcription factors in TERT-mutant thyroid cancers
Funding Source:	American Association of University Women
Role:	Collaborator

Date:	2017 - 2018
Title:	Mechanisms of Resistance to Targeted Therapies in Papillary Thyroid Cancer
Funding Source:	MDACC Bridge Funding
Role:	PI
ID:	2017-00054255-Y1

Date:	2017 - 2022
Title:	Mechanisms of resistance to targeted therapies in papillary thyroid cancers
Funding Source:	NIH/NCI
Role:	PI

Date:	2016 - 2019
Title:	Mechanisms of resistance to kinase inhibitors
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI
ID:	RP170124

Date:	2016 - 2018
Title:	Targeting Anaplastic Thyroid Cancer with Aptamer-Based Therapy
Funding Source:	MDACC IRG
Role:	PI
ID:	2017-00054242-Y2

Date:	2016 - 2017
Title:	in vitro and in vivo testing of FSHR agonists in Sertoli cells
Funding Source:	Tocopherex
Role:	PI

Date:	2016 - 2021
Title:	Deciphering the roles of E2F1 in germ cell maintenance and male fertility
Funding Source:	NIH-NICHD
Role:	Collaborator
ID:	1 R01-HD084470-A1

Date:	2015 - 2017
Title:	Targeting Anaplastic Thyroid Cancer with Aptamer-Based Therapy
Funding Source:	Elsa Pardee Foundation
Role:	PI

Date:	2015 - 2018
Title:	Immune markers in anaplastic and poorly differentiated thyroid cancer and their clinical significance
Funding Source:	Ohio State University / NIH/NCI - CDP Award
Role:	Co-I
ID:	5 P50 CA168505-05

Date:	2015 - 2017
Title:	Improving sperm count in oligospermia
Funding Source:	NIH-NICHD
Role:	PI
ID:	1R21HD086291-01

Date:	2015 - 2016
Title:	Assessing the male reproductive toxicity of kinase inhibitors
Funding Source:	NIH-NICHD
Role:	Other Significant Contributor
ID:	1R03HD086298-01

Date:	2015 - 2019
Title:	Role of ETV5 in BRAF-mutated thyroid cancer and melanoma progression
Funding Source:	Daymon-Runyon Cancer Research Foundation
Role:	Mentor

Date:	2015 - 2018
Title:	Targeting Anaplastic Thyroid Cancer
Funding Source:	Cancer Research Institute (CRI)
Role:	Mentor

Date:	2014 - 2016
Title:	Developmental Research Grant: Role of the Transcription Factor ETV5 in Thyroid Cancer
Funding Source:	NIH/NCI
Role:	Project Leader
ID:	1 P50 CA168505-01A1

Date:	2014 - 2021
Title:	Molecular Regulation of the Perinatal Male Germ Cell Niche
Funding Source:	NIH-NICHD
Role:	PI
ID:	R01 HD 081244

Date:	2014 - 2015
Title:	Novel mechanisms of kinase inhibitors resistance in papillary thyroid cancer
Funding Source:	Elsa U. Pardee Foundation
Role:	PI

Date:	2014 - 2015
Title:	Mechanisms of Mutated BRAF Inhibitor Resistance in Papillary Thyroid Cancer
Funding Source:	American Cancer Society (ACS)
Role:	Mentor

Date:	2014 - 2017
Title:	NOTCH signaling as a regulator of germ cell fate in the perinatal testis
Funding Source:	March of Dimes
Role:	PI

Date:	2014 - 2015
Title:	Mechanisms of Resistance to Targeted Therapy in Papillary Thyroid Cancer (PTC)
Funding Source:	Mike Hogg Fund
Role:	Co-PI

Date:	2014 - 2017
Title:	Mechanisms of acquired resistance to targeted therapies in BRAF V600E mutation-driven human cancers
Funding Source:	V-Foundation pre-proposal
Role:	Co-PI

Date:	2014 - 2015
Title:	Mechanisms of Vemurafenib Resistance in BRAF-mutated Papillary Thyroid Cancer (PTC)
Funding Source:	Peter Bradley Carlson Charitable Trust
Role:	Co-PI

Date:	2013 - 2014
Title:	Mechanisms of Vemurafenib Resistance in BRAF-mutated Papillary Thyroid Cancer (PTC)
Funding Source:	American Thyroid Association
Role:	Co-I

Date:	2013 - 2014
Title:	Mechanisms of acquired resistance to targeted therapies in kinase-driven human cancers: lessons from BRAF-mutated Papillary Thyroid Cancer (PTC)
Funding Source:	MDACC/Knowledge Gap RFA
Role:	Co-PI

Date:	2012 - 2017
Title:	Signaling crosstalks regulating perinatal male germ cell fate
Funding Source:	NIH-NICHD
Role:	PI
ID:	1R01HD072771-01

Date:	2011 - 2015
Title:	Role of HES/HEY family of proteins in mammalian spermatogenesis
Funding Source:	NIH-NICHD
Role:	PI
ID:	5R21HD068989-02

Date:	2010 - 2012
Title:	Emergent Behaviors of Integrated Cellular Systems
Funding Source:	National Science Foundation (NSF)
Role:	Co-I
ID:	NSF-FTC

Date:	2007 - 2013
Title:	Isolation and Characterization of Testis Stem Cells; Influence of GDNF
Funding Source:	NIH-NICHD
Role:	PI
ID:	K02-HD054607

Date:	2005 - 2007
Title:	Real time monitoring of signaling pathways in biological cells
Funding Source:	DARPA
Role:	Co-PI
ID:	SBIR-D2-0449

Date:	2004 - 2010
Title:	Isolation and characterization of testis stem cells
Funding Source:	NIH-NICHD
Role:	PI
ID:	5R01HD044543-05

Date:	2002 - 2003
Title:	Gene Expression Profile of Experimental Seminoma Compared to its Normal Counterpart
Funding Source:	Lance Armstrong Foundation
Role:	PI

Date:	1998 - 2003
Title:	Long-term Culture of Spermatogonial Stem Cells
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	5R01HD036483-05

Title:	Nanosecond pulsed field ablation for treating aggressive thyroid cancers
Funding Source:	CPRIT
Role:	PI

Title:	Redefining Treatment: Novel Strategies for Anaplastic Thyroid Cancer
Funding Source:	NIH NCI
Role:	PI

Title:	Exploring immunotherapy options for lethal anaplastic thyroid cancer
Funding Source:	CPRIT
Role:	Co-I

Title:	Mechanisms of anaplastic thyroid cancer bone metastasis and effects of combinatorial therapies with bone-targeted treatments
Funding Source:	Department of Defense
Role:	Co-I

Title:	Targeted Therapy Combined with Pembrolizumab in Anaplastic Thyroid Cancer: Predicting and Monitoring Treatment Response
Funding Source:	GATEWAY for Cancer Research
Role:	Co-I

Title:	Targeting BMP7 in Combination with Radiotherapy in Anaplastic Thyroid Cancer
Funding Source:	Department of Defense
Role:	PI
ID:	RA250469

Title:	Biomechanical Modulation of Multi-Drug Resistance Evolution in Anaplastic Thyroid Cancer [Edit]
Funding Source:	DoD
Role:	PI

Title:	Preservation of Fertility in Male Cancer Patients through a Pharmacological Approach
Funding Source:	Elsa Pardee Foundation
Role:	PI

Selected Publications

Peer-Reviewed Articles

Hamidi S, Maniakas A, Akhave NS, Banuchi V, Busaidy NL, Dadu R, Ferrarrotto R, Guise TA, Hofmann MC, Hosseini SM, Hu M, Iyer PC, Mansour M, Marczyk VR, Roy-Chowduri S, Sherman SI, Sousa LG, Wang JR, Williams MD, Zafereo ME, Waguespack SG, Cabanillas ME. Characterization of RAS-driven follicular-derived thyroid cancers and review of future therapeutic avenues. JCEM 111(2):471-483, 2026. e-Pub 2026. PMID: 40568752.
Li S, Wu CC, Marczyk VR, Loberg MA, Thennavan A, Tarabichi M, Xu L, Henderson YC, Tran TM, Hofmann M, Zhao X, Lai SY, Williams MD, Wang W, Hamidi S, Zafereo ME, Cabanillas ME, Navin N, Weiss VL, Wang JR. PRECISE: A prognostic thyroid follicular-cell specific gene signature for papillary thyroid carcinoma. Clini Cancer Res. e-Pub 2025. PMID: 42008746.
Houl JH, Bagheri-Yarmand R, Kunnimalaiyaan M, Parek PA, Chari N, McBeath E, Dadbin A, Henderson Y, Powell RT, Stephan C, Cabanillas ME, Lai SY, Dadu R, Zafereo M, Hofmann MC. Role of the ETV5/p38 Signaling Axis in BRAF-Mutated Anaplastic Thyroid Cancers. Molecular Cancer Therapeutics. e-Pub 2025. PMID: 41544239.
Cabanillas, ME, Akhave, NS, Banuchi, VE, Busaidy, NL, Dadu, R, Ferrarotto, R, Gunn, GB, Hamidi, S, Hofmann, M, Hosseini, SM, Iyer, PC, Lai, SY, Lee, A, Maniakas, A, Ning, M, Spiotto, MT, Wang, RJ, Williams, MD, Zafereo, M. Reimagining the Therapeutic Approach for Anaplastic Thyroid Cancer. Thyroid 35(5):462-470, 2025. e-Pub 2025. PMID: 40388579.
Bagheri-Yarmand R, Pagnotti GM, Kidd JL, Avila Ramirez D, Trivedi T, Guerra L, Martinez Cruz L, Martinez JA, Wan X, Song JH, Lin S-H, Sherman SI, Hofmann MC, Guise T. Activating RET Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer. Cell Reports Medicine. e-Pub 2025.
Houl JH, Bagheri-Yarmand R, Dabin A, Miranda-Mendez P, Wang JR, Fraustro A, Hamidi S, Maniakas A, Iyer P, Busaidy NL, Dadu R, Lai SY, Zafereo M, Cabanillas ME, Hofmann MC. Targeting the MAPK and DNA Repair Pathways in Poorly Differentiated and Anaplastic Thyroid Cancer Cells. e-Pub 2024.
Iyer P, Hofmann MC, Ferrarotto R, Dadbin A, Gule-Monroe M, Williams M, Dadu R, Gunn GB, Busaidy NL, Wang JR, Zafereo M, Cabanillas ME. Neoadjuvant vemurafenib in patients with BRAF mutated, locally advanced papillary thyroid carcinoma. Thyroid. e-Pub 2024.
Hicks HM, Pozdeyev N, Sams S, Pugazhenthi U, Bales ES, Hofmann MC, McKenna LR, Schweppe RE. Fibronectin Contributes to a BRAF Inhibitor–driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2. Molecular Cancer Research 21(9):867-880, 2023. e-Pub 2023. PMID: 37219859.
Hamidi S, Hofmann MC, Iyer PC, Cabanillas ME, Hu MI, Busaidy NL, Dadu R. New Treatments for Advanced Differentiated Thyroid Cancers and Potential Mechanisms of Drug Resistance. Frontiers in Endocrinology 14, 2023. e-Pub 2023.
Zhao X, Wang RJ, Dadu R, Busaidy NL, Xu L, Learned KO, Chasen NN, Vu T, Maniakas A, Eguia A, Diersing J, Gross N, Goepfert RP, Lai SY, Hofmann MC, Ferrarotto R, Lu C, Gunn GB, Spiotto MT, Subbiah V, Williams MD, Cabanillas ME, Zafereo M. Surgery After BRAF-Directed Therapy Is Associated with Improved Survival in BRAFV600EMutant Anaplastic Thyroid Cancer. Thyroid 33(4):484-491, 2023. e-Pub 2023. PMID: 36762947.
Rose MM, Espinoza VL, Hoff KJ, Pike LA, Sharma V, Hofmann MC, Tan AC, Pozdeyev N, Schweppe RE. BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer. Cancers 15(2), 2023. e-Pub 2023. PMID: 36672327.
Björndahl L, Barratt CLR, Mortimer D, Agarwal A, Aitken RJ, Alvarez JG, Aneck-Hahn N, Arver S, Baldi E, Bassas L, Boitrelle F, Bornman R, Carrell DT, Castilla JA, Cerezo Parra G, Check JH, Cuasnicu PS, Darney SP, de Jager C, De Jonge CJ, Drevet JR, Drobnis EZ, Du Plessis SS, Eisenberg ML, Esteves SC, Evgeni EA, Ferlin A, Garrido N, Giwercman A, Goovaerts IGF, Haugen TB, Henkel R, Henningsohn L, Hofmann MC, Hotaling JM, Jedrzejczak P, Jouannet P, Jørgensen N, Kirkman Brown JC, Krausz C, Kurpisz M, Kvist U, Lamb DJ, Levine H, Loveland KL, McLachlan RI, Mahran A, Maree L, Martins da Silva S, Mbizvo MT, Meinhardt A, Menkveld R, Mortimer ST, Moskovtsev S, Muller CH, Munuce MJ, Muratori M, Niederberger C, O'Flaherty C, Oliva R, Ombelet W, Pacey AA, Palladino MA, Ramasamy R, Ramos L, Rives N, Roldan ER, Rothmann S, Sakkas D, Salonia A, Sánchez-Pozo MC, Sapiro R, Schlatt S, Schlegel PN, Schuppe HC, Shah R, Skakkebæk NE, Teerds K, Toskin I, Tournaye H, Turek PJ, van der Horst G, Vazquez-Levin M, Wang C, Wetzels A, Zeginiadou T, Zini A. Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology. Human Reproduction 37(11):2497-2502, 2022. e-Pub 2022.
Bagheri-Yarmand R, Busaidy NL, Fujiwara E, Danysh BP, Evans KW, Moss T, Akcakanat A, Ng PS, Knippler CM, Golden JA, Williams MD, Multani AS, Cabanillas ME, Shaw KR, Meric-Bernstam F, Shah MH, Ringel MD, Hofmann MC. Rac1 alterations induce acquired dabrafenib resistance in association with anaplastic transformation in a papillary thyroid cancer patient. Cancers 13(19), 2021. e-Pub 2021. PMID: 34638434.
Henderson YC, Mohamed ASR, Maniakas A, Chen Y, Powell RT, Peng S, Cardenas M, Williams MD, Bell D, Zafereo ME, Wang RJ, Scherer SE, Wheeler DA, Cabanillas ME, Hofmann MC, Johnson FM, Stephan CC, Sandulache V, Lai SY. A High-Throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma. Journal of Clinical Endocrinology and Metabolism 106(10):2962-2978, 2021. e-Pub 2021. PMID: 34120183.
Maniakas A, Henderson YC, Hei H, Peng S, Chen Y, Jiang Y, Ji S, Cardenas M, Chiu Y, Bell D, Williams MD, Hofmann MC, Scherer SE, Wheeler DA, Busaidy NL, Dadu R, Wang JR, Cabanillas ME, Zafereo M, Johnson FM, Lai SY. Novel anaplastic thyroid cancer PDXs and cell lines: Expanding preclinical models of genetic diversity. J Clin Endocrinol Metab 106(11):e4652-e4665, 2021. e-Pub 2021. PMID: 34147031.
Qin Y, Wang JR, Wang Y, Iyer P, Cote GJ, Busaidy NL, Dadu R, Zafereo M, Williams MD, Ferrarotto R, Gunn GB, Wei P, Patel K, Hofmann MC, Cabanillas ME. Clinical Utility of Circulating Cell-free DNA Mutations in Anaplastic Thyroid Carcinoma. Thyroid 31(8):1235-1243, 2021. e-Pub 2021. PMID: 33599171.
Maniakas A, Dadu R, Busaidy NL, Wang RJ, Ferrarotto R, Lu C, Williams MD, Gunn GB, Hofmann MC, Cote G, Sperling J, Gross N, Sturgis EM, Goepfert RP, Lai SY, Cabanillas ME, Zafereo M. Evaluation of Overall Survival in Patients with Anaplastic Thyroid Carcinoma, 2000-2019. JAMA Oncology 6(9):1397-1404, 2020. e-Pub 2020. PMID: 32761153.
Cabanillas ME, Dadu R, Iyer P, Wanland KB, Busaidy NL, Ying A, Gule-Monroe M, Wang JR, Zafereo M, Hofmann MC. Acquired secondary RAS mutation in BRAFV600E -mutated thyroid cancer patients treated with BRAF inhibitors. Thyroid 30(9):1288-1296, 2020. e-Pub 2020. PMID: 32216548.
Fujiwara E, Parker-Thornburg J, Fujii Y, Aryal NK, Smith CN, Hofmann MC, Abe J, Fujiwara K. Rapid evaluation of CRISPR guides and donors for engineering mice. Genes 11(6):1-25, 2020. e-Pub 2020. PMID: 32521708.
Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Danysh B, Shetty G, Maeistrich M, Hofmann MC. Undifferentiated spermatogonia regulate postnatal expression of CYP26B1 through NOTCH signaling in Sertoli cells. FASEB J 33(7):8423-8435, 2019. e-Pub 2019. PMID: 30991836.
Parekh P, Garcia TX, Hofmann MC. Regulation of GDNF expression in Sertoli cells. Reproduction 157(3):R95-R107, 2019. e-Pub 2019. PMID: 30620720.
Iyer PC, Cote GJ, Hai T, Gule-Monroe M, Bui JH, Williams MD, Hess KN, Hofmann MC, Dadu R, Zafereo M, Busaidy NL, Ferrarotto, Subbiah V, Gross N, Gunn BG, Skinner HD, Garden AS, Cabanillas ME. Circulating BRAF V600E cell free DNA (cfDNA) as a biomarker in the management of Anaplastic Thyroid Carcinoma. JCO Precision Oncology 2:1-11, 2018. e-Pub 2018.
Puli OR, Danysh BP, McBeal-Fujiwara EM, Sinha, DT, Koang J, Powell RT, Cabanillas ME, Cote GJ, Hofmann MC. The transcription factor ETV5 mediates BRAFV600E-induced proliferation and TWIST1 expression in papillary thyroid cancer cells. Neoplasia 20(11):1121-1134, 2018. e-Pub 2018. PMID: 30265861.
Paez-Mayorga J, Kotla S, Tao Y, Giancursio C, Danysh BP, Hofmann MC, Le NT. Ponatinib activates an inflammatory response in endothelial cells via ERK5 SUMOylation. Front. Cardiovasc. Med 5:125, 2018. e-Pub 2018. PMID: 30238007.
Cabanillas M, Ferrarotto R, Garden A, Ahmed S, Busaidy N, Dadu R, Williams M, Skinner H, Gunn B, Grosu H, Iyer P, Hofmann MC, Zafereo M. Neoadjuvant BRAF- and immune-directed therapy for anaplastic thyroid carcinoma. Thyroid 28(7):945-951, 2018. e-Pub 2018. PMID: 29742974.
Beadnell TC, Wuensch KE, Clark EG, Danysh BP, Hofmann MC, Pozdeyev N, Schweppe RE. Src Mediated Regulation of the PI3K Pathway in Advanced Papillary and Anaplastic Thyroid Cancer. Oncogenesis 17(2):23-36, 2018. e-Pub 2018. PMID: 29487290.
Iyer PC, Cote G, Hai T, Gule-Monroe MK, Bui-Griffith J, Williams MD, Hess KR, Hofmann MC, Dadu R, Zafereo M, Busaidy NL, Ferrarotto R, Subbiah V, Gross N, Gunn GB, Skinner H, Garden AS, Cabanillas ME. Circulating BRAF V600E cell-free DNA as a biomarker in the management of anaplastic thyroid carcinoma. JCO Precision Oncology 2:1-11, 2018. e-Pub 2018. PMID: 35135166.
Garcia TX, Parekh P, Gandhi P, Sinha K, Hofmann MC. The NOTCH ligand JAG1 regulates GDNF expression in Sertoli cells. Stem Cells & Development 26(8):585-598, 2017. e-Pub 2017. PMID: 28051360.
Liang S, Yin L, Shengyang Yu K, Hofmann MC, and Yu X. High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells. Toxicol Sci 155(1):43-60, 2017. e-Pub 2017. PMID: 27633978.
Danysh BP, Rieger E, Sinha D, Cabanillas M, Cote G, Hofmann MC. Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model. Oncotarget 7(21):30907-30923, 2016. e-Pub 2016. PMID: 27127178.
Garcia TX, Hofmann MC. Regulation of germ line stem cell homeostasis. Animal Reproduction 12(1):35-45, 2015. e-Pub 2015.
Cote GJ, Grubbs EG, Hofmann MC. Thyroid C-Cell biology and Oncogenic Transformation. Recent Results Cancer Res 204:1-39, 2015. e-Pub 2015. PMID: 26494382.
Phan LM, Fuentes-Mattei E, Wu W, Velazquez-Torres V, Sircar K, Wood CG, Hai T, Jimenez C, Cote GJ, Hofmann MC, Verhaak R, Pagliaro L, Lee MH, Yeung SCJ, and Habra MA. Hepatocyte growth factor/cMET pathway activation enhances cancer hallmarks in adrenocortical carcinoma: a potential therapeutic target. Cancer Research 75(19):4131-4142, 2015. e-Pub 2015. PMID: 26282167.
Garcia TX, Farmaha JK, Kow S, Hofmann MC. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development 141(23):4468-4478, 2014. e-Pub 2014. PMID: 25406395.
Garcia TX, Costa GM, Franca LR, Hofmann MC. Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol 45(6):59-70, 2014. e-Pub 2014. PMID: 24447867.
Hofmann MC. Stem cells and nanomaterials. Advances in experimental medicine and biology 811:255-275, 2014. e-Pub 2014. PMID: 24683036.
Gabrielson NP, Desai AV, Mahadik B, Hofmann MC, Kenis PJ, Harley BA. Cell-Laden Hydrogels in Integrated Microfluidic Devices for Long-Term Cell Culture and Tubulogenesis Assays. Small 9(18):3076-81, 2013. e-Pub 2013. PMID: 23468408.
Garcia TX, Hofmann MC. NOTCH signaling in Sertoli cells regulates gonocyte fate. Cell Cycle 12(16):2538-45, 2013. e-Pub 2013. PMID: 23907117.
Garcia TX, DeFalco T, Capel B, Hofmann MC. Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. Dev Biol 377(1):188-201, 2013. e-Pub 2013. PMID: 23391689.
Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA, Jimenez C. Bone Metastases and Skeletal Related Events in Patients with Malignant Pheochromocytoma and Sympathetic Paraganglioma. J Clin Endocrinol Metab 98(4):1492-7, 2013. e-Pub 2013. PMID: 23436918.
Lucas BE, Fields C, Joshi N, Hofmann MC. Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signaling in mouse stem-progenitor spermatogonia. Toxicology 299(1):10-9, 2012. e-Pub 2012. PMID: 22564763.
Campos-Junior PH, Costa GM, Lacerda SM, Rezende-Neto JV, de Paula AM, Hofmann MC, de França LR. The spermatogonial stem cell niche in the collared peccary (Tayassu tajacu). Biol Reprod 86(5):155, 1-10, 2012. e-Pub 2012. PMID: 22262689.
Garcia T, Hofmann MC. Isolation of undifferentiated and early differentiating type A spermatogonia from Pou5f1-GFP reporter mice. Methods Mol Biol 825:31-44, 2012. e-Pub 2012. PMID: 22144234.
Costa GM, Avelar GF, Rezende-Neto JV, Campos-Junior PH, Lacerda SM, Andrade BS, Thomé RG, Hofmann MC, Franca LR. Spermatogonial stem cell markers and niche in equids. PLoS One 7(8):e44091, 2012. e-Pub 2012. PMID: 22937157.
Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS, Hofmann MC. ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells 28(10):1882-92, 2010. e-Pub 2010. PMID: 20799334.
Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC. Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci 116(2):577-89, 2010. e-Pub 2010. PMID: 20488942.
Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction 139(6):1011-20, 2010. e-Pub 2010. PMID: 20371641.
Morrow CM, Tyagi G, Simon L, Carnes K, Murphy KM, Cooke PS, Hofmann MC, Hess RA. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod 81(5):871-9, 2009. e-Pub 2009. PMID: 19571261.
Tyagi G, Carnes K, Morrow C, Kostereva NV, Ekman GC, Meling DD, Hostetler C, Griswold M, Murphy KM, Hess RA, Hofmann MC, Cooke PS. Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod 81(2):258-66, 2009. e-Pub 2009. PMID: 19369650.
Simon L, Ekman GC, Kostereva N, Zhang Z, Hess RA, Hofmann MC, Cooke PS. Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells 27(7):1666-75, 2009. e-Pub 2009. PMID: 19544441.
Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis. Biol Reprod 80(4):707-17, 2009. e-Pub 2009. PMID: 19109221.
Chu C, Schmidt JJ, Carnes K, Zhang Z, Kong HJ, Hofmann MC. Three-dimensional synthetic niche components to control germ cell proliferation. Tissue Eng Part A 15(2):255-62, 2009. e-Pub 2009. PMID: 18816170.
Schlesser HN, Simon L, Hofmann MC, Murphy KM, Murphy T, Hess RA, Cooke PS. Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod 78(3):483-9, 2008. e-Pub 2008. PMID: 18032421.
He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells 26(1):266-78, 2008. e-Pub 2008. PMID: 17962702.
He Z, Jiang J, Hofmann MC, Dym M. Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod 77(4):723-33, 2007. e-Pub 2007. PMID: 17625109.
Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC. Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol 304(1):34-45, 2007. e-Pub 2007. PMID: 17222400.
Braydich-Stolle L, Nolan C, Dym M, Hofmann MC. Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Ann N Y Acad Sci 1061:94-9, 2005. e-Pub 2005. PMID: 16467260.
Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88(2):412-9, 2005. e-Pub 2005. PMID: 16014736.
Chen C, Ouyang W, Grigura V, Zhou Q, Carnes K, Lim H, Zhao GQ, Arber S, Kurpios N, Murphy TL, Cheng AM, Hassell JA, Chandrashekar V, Hofmann MC, Hess RA, Murphy KM. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature 436(7053):1030-4, 2005. e-Pub 2005. PMID: 16107850.
Hofmann MC, Braydich-Stolle L, Dym M. Isolation of male germ-line stem cells; influence of GDNF. Dev Biol 279(1):114-24, 2005. e-Pub 2005. PMID: 15708562.
Hofmann MC, Braydich-Stolle L, Dettin L, Johnson E, Dym M. Immortalization of mouse germ line stem cells. Stem Cells 23(2):200-10, 2005. e-Pub 2005. PMID: 15671143.
Dettin L, Ravindranath N, Hofmann MC, Dym M. Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis. Biol Reprod 69(5):1565-71, 2003. e-Pub 2003. PMID: 12855601.
Hofmann MC, Van Der Wee KS, Dargart JL, Dirami G, Dettin L, Dym M. Establishment and characterization of neonatal mouse sertoli cell lines. J Androl 24(1):120-30, 2003. e-Pub 2003. PMID: 12514093.
van der Wee KS, Johnson EW, Dirami G, Dym TM, Hofmann MC. Immunomagnetic isolation and long-term culture of mouse type A spermatogonia. J Androl 22(4):696-704, 2001. e-Pub 2001. PMID: 11451367.
Billotte WG, Dumas K, Hofmann MC. Transcriptional pathways induced by fluid shear stress in mouse preosteoblast cells. Biomed Sci Instrum 37:1-6, 2001. e-Pub 2001. PMID: 11347369.
van der Wee K, Hofmann MC. An in vitro tubule assay identifies HGF as a morphogen for the formation of seminiferous tubules in the postnatal mouse testis. Exp Cell Res 252(1):175-85, 1999. e-Pub 1999. PMID: 10502410.
Encina NR, Billotte WG, Hofmann MC. Immunomagnetic isolation of osteoprogenitors from human bone marrow stroma. Lab Invest 79(4):449-57, 1999. e-Pub 1999. PMID: 10211997.
Billotte WG, Hofmann MC. Establishment of a shear stress protocol to study the mechanosensitivity of human primary osteogenic cells in vitro. Biomed Sci Instrum 35:327-32, 1999. e-Pub 1999. PMID: 11143372.
Hofmann MC, Millan JL. Establishment of Mammalian Testicular Cell Lines. Methods Cell Biol 57:93-10, 1998. e-Pub 1998. PMID: 9648101.
Wolkowicz MJ, Coonrod SA, Reddi PP, Millan JL, Hofmann MC, Herr JC, Coonrod SM. Refinement of the differentiated phenotype of the spermatogenic cell line GC-2spd(ts). Biol Reprod 55(4):923-32, 1996. e-Pub 1996. PMID: 8879510.
Hofmann MC, Abramian D, Millán JL. A haploid and a diploid cell coexist in an in vitro immortalized spermatogenic cell line. Dev Genet 16(2):119-27, 1995. e-Pub 1995. PMID: 7736662.
Hofmann MC, Hess RA, Goldberg E, Millán JL. Immortalized germ cells undergo meiosis in vitro. Proc Natl Acad Sci U S A 91(12):5533-7, 1994. e-Pub 1994. PMID: 8202522.
Cooker LA, Brooke CD, Kumari M, Hofmann MC, Millán JL, Goldberg E. Genomic structure and promoter activity of the human testis lactate dehydrogenase gene. Biol Reprod 48(6):1309-19, 1993. e-Pub 1993. PMID: 8318584.
Narisawa S, Hofmann MC, Ziomek CA, Millán JL. Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse. Development 116(1):159-65, 1992. e-Pub 1992. PMID: 1483384.
Hofmann MC, Narisawa S, Hess RA, Millán JL. Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen. Exp Cell Res 201(2):417-35, 1992. e-Pub 1992. PMID: 1322317.
Walt H, Emmerich P, Cremer T, Hofmann MC, Bannwart F. Supernumerary chromosome 1 in interphase nuclei of atypical germ cells in paraffin-embedded human seminiferous tubules. Lab Invest 61(5):527-31, 1989. e-Pub 1989. PMID: 2811300.
Hofmann MC, Jeltsch W, Brecher J, Walt H. Alkaline phosphatase isozymes in human testicular germ cell tumors, their precancerous stage, and three related cell lines. Cancer Res 49(17):4696-700, 1989. e-Pub 1989. PMID: 2547514.
Emmerich P, Jauch A, Hofmann MC, Cremer T, Walt H. Interphase cytogenetics in paraffin embedded sections from human testicular germ cell tumor xenografts and in corresponding cultured cells. Lab Invest 61(2):235-42, 1989. e-Pub 1989. PMID: 2755080.
Hamidi Sarah, Iyer Priyanka, Maniakas Anastasios, Akhave Neal, Ferrarotto Renata, Zafereo Mark, Hofmann Marie-Claude, Cabanillas Maria, Vodopivec Danica, Busaidy Naifa, Gule-Monroe Maria Kristina, Banuchi Victoria, Gunn Brandon, Lee Anna, Marczyk Vicente, Ning Matthew, Sousa Luana, Spiotto Michael, Waguespack Stephen, Wang Jennifer, Fournier Isabelle, Dadu Ramona. Real-world Experience with Lenvatinib plus Pembrolizumab in Metastatic BRAF wild-type Anaplastic Thyroid Carcinoma. Thyroid.
Bagheri-Yarmand R, Sinha K, Grubbs E, Hu M, Gagel R, Dadu R, Sherman SI, Hofmann MC. RET-dependent regulation of the histone demethylase RIOX1 in medullary thyroid cancer.

Review Articles

Sthanam LK, Miranda-Mendez, McBeath Elena, Cruz L, Bagheri-Yarmand R, Hofmann MC. RAC1 Signaling in Polyploid Giant Cancer Cells: Implications for Tumorigenesis and Therapy Resistance. Cancer Letters. e-Pub 2025. PMID: 42184921.
Yarmand, R, Grubbs, EG, Hofmann, M. Thyroid C-Cell Biology and Oncogenic Transformation. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 223:51-91, 2025. e-Pub 2025. PMID: 40102254.
Fujiwara E, Fujiwara K, Hofmann MC. Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. International journal of molecular sciences 24(12), 2023. e-Pub 2023. PMID: 37373404.
Hamidi, S, Hofmann, M, Iyer, PC, Cabanillas, ME, Hu, MI, Busaidy, NL, Dadu, R. New treatments for advanced differentiated thyroid cancers and potential mechanisms of drug resistance. Frontiers in Endocrinology 14, 2023. e-Pub 2023. PMID: 37435488.
Björndahl, L, Barratt, CL, Mortimer, D, Agarwal, A, Aitken, RJ, Alvarez, JG, Aneck-Hahn, N, Arver, S, Baldi, E, Bassas, L, Boitrelle, F, Bornman, R, Carrell, DT, Castilla, JA, Parra, GC, Check, JH, Cuasnicu, PS, Darney, SP, de Jager, C, De Jonge, CJ, Drevet, JR, Drobnis, EZ, Du Plessis, SS, Eisenberg, ML, Esteves, SC, Evgeni, EA, Ferlin, A, Garrido, N, Giwercman, A, Goovaerts, IG, Haugen, TB, Henkel, R, Henningsohn, L, Hofmann, M, Hotaling, JM, Jedrzejczak, P, Jouannet, P, Jørgensen, N, Kirkman Brown, JC, Krausz, C, Kurpisz, M, Kvist, U, Lamb, DJ, Levine, H, Loveland, KL, McLachlan, RI, Mahran, A, Maree, L, da Silva, SM, Mbizvo, MT, Meinhardt, A, Menkveld, R, Mortimer, ST, Moskovtsev, S, Muller, CH, José Munuce, M, Muratori, M, Niederberger, CS, O’Flaherty, C, Oliva, R, Ombelet, W, Pacey, AA, Palladino, MA, Ramasamy, R, Ramos, L, Rives, N, Rs Roldan, E, Rothmann, SA, Sakkas, D, Salonia, A, Sánchez-Pozo, MC, Sapiro, R, Schlatt, S, Schlegel, PN, Schuppe, HC, Shah, R, Skakkebæk, N, Teerds, K, Toskin, I, Tournaye, H, Turek, PJ, van der Horst, G, Vazquez-Levin, M, Wang, C, Wetzels, A, Zeginiadou, T, Zini, A. Standards in semen examination. Human Reproduction 37(11):2497-2502, 2022. e-Pub 2022. PMID: 36112046.
Hofmann MC, Kunnimalaiyaan M, Wang RJ, Busaidy NL, Sherman SI, Lai SY, Zafereo M, Cabanillas ME. Molecular mechanisms of resistance to kinase inhibitors and redifferentiation in thyroid cancers. Endocrine-related cancer 29(11):R173-R190, 2022. e-Pub 2022. PMID: 35975971.
Hofmann MC, Giwercman A. Andrology and humanities. Andrology 10(5):823-824, 2022. e-Pub 2022. PMID: 35763405.
Hofmann MC, Fujiwara E. Sertoli Cell-Germ Cell Interactions Within the Niche. Frontiers in Endocrinology 13, 2022. e-Pub 2022. PMID: 35757413.
França LR, Hess RA, Dufour JM, Hofmann MC, Griswold MD. The Sertoli cell: one hundred fifty years of beauty and plasticity. Andrology 4(2):189-212, 2016. e-Pub 2016. PMID: 26846984.
Waheeb R, Hofmann MC. Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl 34(4 Pt 2):e296-305; discussion e305, 2011. e-Pub 2011. PMID: 21790653.
Lucas B, Fields C, Hofmann MC. Signaling pathways in spermatogonial stem cells and their disruption by toxicants. Birth Defects Res C Embryo Today 87(1):35-42, 2009. e-Pub 2009. PMID: 19306349.
Liu CF, Barsoum I, Gupta R, Hofmann MC, Yao HH. Stem cell potential of the mammalian gonad. Front Biosci (Elite Ed) 1:510-8, 2009. e-Pub 2009. PMID: 19482665.
Kostereva N, Hofmann MC. Regulation of the spermatogonial stem cell niche. Reprod Domest Anim 43 Suppl 2:386-92, 2008. e-Pub 2008. PMID: 18638151.
Hofmann MC. Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol 288(1-2):95-103, 2008. e-Pub 2008. PMID: 18485583.
Morrow CM, Hostetler CE, Griswold MD, Hofmann MC, Murphy KM, Cooke PS, Hess RA. ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege. Ann N Y Acad Sci 1120:144-51, 2007. e-Pub 2007. PMID: 17911411.
Hess RA, Cooke PS, Hofmann MC, Murphy KM. Mechanistic insights into the regulation of the spermatogonial stem cell niche. Cell Cycle 5(11):1164-70, 2006. e-Pub 2006. PMID: 16721062.
Tsonis PA, Del Rio-Tsonis K, Wallace JL, Burns JC, Hofmann MC, Millan JL, Washabaugh CH. Can insights into urodele limb regeneration be achieved with cell cultures and retroviruses?. Int J Dev Biol 40(4):813-6, 1996. e-Pub 1996. PMID: 8877455.
Hofmann MC, Millán JL. Developmental expression of alkaline phosphatase genes; reexpression in germ cell tumours and in vitro immortalized germ cells. Eur Urol 23(1):38-44; discussion 45, 1993. e-Pub 1993. PMID: 8386657.

Editorials

Hofmann MC, Giwercman A. Toward standardization in reporting data on basic human semen examination. Andrology 11(7):1223-1224, 2023. PMID: 37740520.
Giwercman, A, Hofmann, M. Editorial. Andrology 11(6):953, 2023. PMID: 37545352.
Giwercman, A, Hofmann, M. Editorial. Andrology 10(8):1459, 2022. PMID: 36250392.
Hofmann MC, Simoni M. Andrology Awards 2019 and 2020. Andrology 9(4):1025-1026, 2021. PMID: 34311501.
Simoni M, Hofmann MC. The COVID-19 pandemics: shall we expect andrological consequences? A call for contributions to ANDROLOGY. Andrology 8(3):1, 2020. PMID: 32302464.

Abstracts

Houl JH, Miranda Mendz P, Bagheri-Yarmand R, Dadbin A, Villarreal Ramos AV, Ramirez Sanchez MA, Fraustro Villarreal A, Cabanillas ME, Thennavan A, Wang JR, Lai SY, Zafereo M, Dadu R, Hofmann MC. Therapeutic Strategies Using BRAF and ATR Inhibitors for drug-resistant BRAF-Mutated Poorly Differentiated and Anaplastic Thyroid Cancers. ATA Annual Meeting Volume 35(S1), 2025. e-Pub 2025.
Barsoumian H, Houl JH, Robinson D, Miranda Mendez P, Cabanillas ME, Welsh J, Hofmann MC. Treating Anaplastic Thyroid Cancer Using a Novel Approach of BMP7 and PD1 Blockade in a Murine Implanted Model. ATA Annual Meeting 35(S1), 2025. e-Pub 2025.
Yuan S, Wan X, Dadbin A, Hofmann MC, Guise TA. Zoledronate Prevents Anaplastic Thyroid Cancer Bone Metastases: Mechanistic Insight into ATC-Bone Interactions. ATA Anual Meeting 35(S1), 2025. e-Pub 2025.
Abubaker A, Henderson Y, Hofmann MC, Busaidy NL, Cabanillas ME, Williams M, Maniakas A, Lai SY. Novel anaplastic thyroid carcinoma patient-derived xenograft models and cell line. AACR Annual Meeting 85(8_S1):4756, 2025. e-Pub 2025.
Bagheri-Yarmand R, Hofmann MC. Progression of a Human Papillary Thyroid Tumor into Aggressive Anaplastic Thyroid Cancer Upon Dabrafenib Treatment: Pleiotropic Roles of the Small GTPase RAC1. First International Conference on Polyploid Giant Cancer Cells - Biology and Clinical Applications, 2025. e-Pub 2025.
Houl J, Yarmand R, Miranda P, Dominguez C, Ramirez L, Henderson Y, Lai S, Cabanillas M, Zafereo M, Dadu R, Hofmann MC. Role of p38/MAPK in Aggressive Thyroid Cancers. ENDO Meeting 8(S1), 2024. e-Pub 2024.
Houl JH, Mendez PM, Wang JR, Hamidi S, Maniakas A, Iyer PC, Lai SY, Cabanillas M, Busaidy NL, Dadu R, Zafereo M, Hofmann MC. Targeting the MAPK and DNA Repair Pathways in Poorly Differentiated and Anaplastic Thyroid Cancer Cells. American Thyroid Association Annual Meeting 34(S1):A54, 2024. e-Pub 2024.
Yuan S, Wan X, Dadbin A, Hofmann M, Guise TA. Anaplastic Thyroid Cancer Bone Metastasis: Mechanistic Insight From Mouse Models. American Thyroid Association Annual Meeting, 2024. e-Pub 2024.
Ruiz AJ, Herrera MO, Kidd JL, Guise TA, Hofmann M, Hu MI, Bagheri-Yarmand R. Site-specific HRASQ61R activation promotes cell proliferation via activation of the PI3kinase/Akt pathway and p53 inactivation in medullary thyroid cancer. American Thyroid Association Annual Meeting 34(S1):A52, 2024. e-Pub 2024.
Sarah Hamidi, Ramona Dadu, Mark Zafereo, Jennifer Wang, Sinchita Roy-Chowdhuri, Michelle Williams, Renata Ferrarotto, Neal Akhave, Luana Sousa, Priyanka Iyer, Vicente Marczyk, Theresa Guise, Marie-Claude Hofmann, Naifa Busaidy, Anastasios Maniakas, Maria Cabanillas. Characterization of RAS-mutant Anaplastic Thyroid Carcinoma (ATC). Annual Meeting of the American Thyroid Association 34(S1):A137, 2024. e-Pub 2024.
Hamidi S, Maniakas A, Chowdhuri SR, Dadu R, Waguespack S, Hu MI, Sherman SI, Iyer PC, Marczyk VR, Guise TA, Hofmann MC, Busaidy NL, Wang JR, Zafereo ME, Cabanillas ME. Clinicopathological Features of Advanced, RAS-driven Differentiated Thyroid Carcinoma (DTC). American Thyroid Association Annual Meeting 34(S1):A139, 2024. e-Pub 2024.
Houl JH, Bagheri-Yarmand R, Mendez PM, Chari N, Henderson Y, Wang JR, Hamidi S, Maniakas A, Iyer PC, Lai SY, Cabanillas M, Busaidy NL, Dadu R, Zafereo M, Hofmann AM. Role of the ETV5/p38 Signaling Axis in BRAF-Mutated Anaplastic Thyroid Cancers. American Thyroid Association Annual Meeting 34(S1):A54, 2024. e-Pub 2024.
McBeath E, Fujiwara K, Hofmann MC. Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. ASCB/EMBO meeting 35(1), 2023. e-Pub 2023.
McBeath E, Fujiwara K, Hofmann MC. Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. Transgenic Technology Meeting 32(1), 2023. e-Pub 2023.
Dadbin A, McBeath-Fujiwara E, Gandhi P, Hofmann MC. Role of LSD1 in Mouse Sertoli Cells. Andrology 11(S1), 2023. e-Pub 2023.
McBeath E, Cruz L, Bagheri-Yarmand R, Hofmann MC. Disruption of Cell Division by P34R Mutated RAC1. Mol Biol Cell 33(15), 2022. e-Pub 2022.
Fazeli S, Hofmann MC, Gule-Monroe M, McBeath E, Cabanillas ME, Busaidy NL, Waguespack SG, Hu M, Jimenez C, Sherman SI, Habra MA, Cote GJ, Bassett R, William MD, Dadu R. BRAF/MEK inhibitor combination therapy in BRAF V600E-mutated papillary thyroid carcinoma: Does the presence of a TERT promoter mutation influence therapeutic response?. Thyroid 32(S1), 2022. e-Pub 2022.
Cruz L, McBeath-Fujiwara E, Bagheri-Yarmand R, Ringel MD, Hofmann MC. Dedifferentiation of a Human Papillary Thyroid Tumor into Aggressive Anaplastic Thyroid Cancer Upon Dabrafenib Treatment: Pleiotropic Roles of the Small GTPase RAC1. Thyroid 32(S1), 2022. e-Pub 2022.
Cruz L, McBeath-Fujiwara E, Bagheri-Yarmand R, Ringel MD, Hofmann MC. Pleiotropic Roles of the Small GTPase RAC1 in Thyroid Cancer. 2022 DoIM Research Retreat Abstracts, 2022. e-Pub 2022.
Kunnimalaiyaan M, Parekh P, Dadbin A, Henderson Y, Lai SY, Cabanillas ME, Marc Zafereo M, Dadu R, Hofmann MC. Novel Targeted Combination Therapies Based on p38MAPK Inhibition in Anaplastic Thyroid Cancer. 2022 DoIM Research Retreat Abstracts, 2022. e-Pub 2022.
Kunnimalaiyaan M, Parekh P, Golden J, Henderson Y, Lai S, Cabanillas M, Zafereo M, Dadu R, Hofmann MC. Novel in Vitro Targeted Combination Therapies for Anaplastic Thyroid Cancer. Molecular Cancer Therapeutics 20(12_Suppl), 2021. e-Pub 2021.
Bagheri-Yarmand R, Busaidy N, McBeath-Fujiwara E, Akcakanat A, Shaw K, Meric-Bernstam F, Williams M, Multani A, Cabanillas M, Shah M, Ringel M, Hofmann MC. RAC1 induces acquired dabrafenib resistance in association with anaplastic transformation in a papillary thyroid cancer patient. Thyroid 31(S1):A-7, 2021. e-Pub 2021.
Bagheri-Yarmand R, Busaidy NL, McBeath E, Danysh B, Evans KW, Moss TJ, Akcakanat A, Ng PK, Golden JA, Shaw KR, Meric-Bernstam F, Williams MD, Multani AS, Cabanillas ME, Shah MH, Ringel MD, Hofmann MC. 2021 RAC1 amplification induces dabrafenib resistance and anaplastic transformation in a papillary thyroid cancer patient. DoIM Retreat Research Abstracts, 2021. e-Pub 2021.
Kunnimalaiyaan M, Parekh P, Golden J, Henderson Y, Lai S, Cabanillas M, Zafereo M, Dadu R, Hofmann MC. Novel in Vitro Targeted Combination Therapies for Anaplastic Thyroid Cancer. 2021 DoIM Research Retreat Abstracts, 2021. e-Pub 2021.
McBeath E, Golden J, Gandhi P, Parker-Thornburg J, Hofmann MC. Generating a Phf21a-Floxed Mouse With a Novel DECAI CRISPR System to Study the Function of BHC80 in Development and Disease. 2021 DoIM Research Retreat Abstracts, 2021. e-Pub 2021.
McBeath-Fujiwara E, Golden JA, Gandhi P, Parker-Thornburg J, Hofmann MC. Generating a Phf21a-Floxed Mouse With a Novel DECAI CRISPR System to Study the Function of BHC80 in Development and Disease. 26th Texas Forum for Reproductive Sciences Abstracts online meeting, 2021. e-Pub 2021.
McBeath E, Hofmann MC. Increased donor DNA sequence integration by CRISPR/Cas9 in mice: Mechanistic insights. Mol Biol Cell 31(26), 2020. e-Pub 2020.
McBeath E, Golden JA, Parker-Thornburg J, Hofmann MC. Floxing Mice Using a Novel DECAI CRISPR System. Transgenic Research 29(S1), 2020. e-Pub 2020.
Fazeli S, Guille-Monroe M, Cabanillas ME, Busaidy NL, Waguespack SG, Hu MI, Jimenez C, Sherman SI, Habra MA, Cote GJ, Hofmann MC, Bassett R, Dadu R. Response to BRAF with/without MEK inhibitors in BRAF plus TERT promoter mutated differentiated thyroid cancers (DTC). 2020 DoIM Research Retreat Abstracts online meeting, 2020. e-Pub 2020.
Bagheri-Yarmand R, McBeath E, Busaidy NL, Golden JA, Danysh BP, Cabanillas ME, Shah M, Ringel M, Hofmann MC. Functional Analysis of an Acquired Novel RAC1P34R Mutation in a Patient under Dabrafenib Treatment. 2020 DoIM Research Retreat Abstracts online meeting, 2020. e-Pub 2020.
McBeath-Fujiwara E, Golden JA, Gandhi P, Parker-Thornburg J, Hofmann MC. Generating a Phf21a-Floxed Mouse With a Novel DECAI CRISPR System, to Study Male Germ Cell Homeostasis. 2020 DoIM Research Retreat Abstracts online meeting, 2020. e-Pub 2020.
McBeath-Fujiwara E, Golden JA, Hofmann MC. Generation of a Phf21a-Floxed Mouse Using a Novel DECAI CRISPR Method. Andrology 8(S1), 2020. e-Pub 2020.
McBeath E, Busaidy NL, Hai T, Danysh BP, Cabanillas ME, Shah M, Ringel M, Hofmann MC. An acquired novel Rac1P34R mutation drives proliferation and actin reorganization in papillary thyroid cancer cells. Thyroid 29(S1), 2019. e-Pub 2019.
Maniakas A, Dadu R, Wang JR, Busaidy NL, Hofmann MC, Sperling J, Gross N, Sturgis E, Goepfert R, Lai SY, Cabanillas ME, Zafereo ME. Revolutionizing the therapeutic landscape of a deadly disease. Thyroid 29(S1), 2019. e-Pub 2019.
Parekh P, Baraa Souman BS, Garcia T, Meistrich M, Shetty G, Hofmann MC. Regulation of blood-testis barrier proteins through NOTCH non-canonical pathways. Proceedings of the XXVth North American Testis Workshop, 2019. e-Pub 2019.
McBeath E, Fujii Y, Cruz L, Abe JI, Hofmann MC, Fujiwara K. SED [Single strand Ended Double strand] DNA donors as an inexpensive, easy to make, and efficiently inserted, long CRISPR donor. Transgenic Research 28(Supplement):Abstract, 2019. e-Pub 2019.
McBeath-Fujiwara E, Hofmann MC. Tissue-Specific Knockout of Genes in Mice Using DECAI CRISPR. Mol Biol Cell 30(26):37, 2019. e-Pub 2019.
Danysh BP, Busaidy N, McBeath E, Sinha D, Evans KW, Akcakanat A, Ng KS, Meric-Bernstam F, Cabanillas ME, Ringel MD, Hofmann MC. An acquired novel RAC1(P34R) mutation drives braf(v600e)-inhibitor resistance in a papillary thyroid cancer patient. 51st Annual Genes Family and Isozymes Conference, 2018. e-Pub 2018.
Parekh PA, Gandhi P, Danysh BP, Shetty G, Meistrich MM, Hofmann MC. BHC80 is a Co-Repressor of NOTCH/RBPJ Signaling in Sertoli Cells. Proceedings of the Society for the Study of Reproduction Annual Meeting:257, 2018. e-Pub 2018.
Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Shetty G, Meistrich M, Hofmann MC. A Subset of Germ Cells Controls Cyp26b1 Expression by Sertoli Cells. Proceedings of the Society for the Study of Reproduction Annual Meeting:429, 2018. e-Pub 2018.
Paez-Mayorga J, Tao Y, Cooke JP, Giancursio C, Ijaz F, Vu HT, Danysh BP, Hofmann MC, Abe JI, Le NT. Ponatinib mediates endothelial inflammation through ERK5 SUMOylation. Vascular Discovery: From Genes to Medicine, Conference Proceedings, 2018. e-Pub 2018.
Parekh PA, Gandhi P, Danysh BP, Shetty G, Meistrich M, Hofmann MC. Role of BHC80/Phf21a in the Spermatogonial Stem Cell Niche. Texas Forum for Reproductive Sciences 24th Annual Meeting, 2018. e-Pub 2018.
McBeath-Fujiwara E, Parker-Thornburg J, Fujii Y, Smith C, Hofmann MC, Abe JI, Fujiwara K. Rapidly increasing knock-in efficiency of CRISPR in mice by using blastocysts as a testing model. Mol Biol Cell 29(26):63, 2018. e-Pub 2018.
Iyer P, Ferrarotto R, Gule-Monroe M, Busaidy NL, Dadu R, Habra MA, Williams MD, Hofmann MC, Zafereo M, Skinner H, Cabanillas ME. Pembrolizumab added to Kinase Inhibitor (KI) therapy in Anaplastic Thyroid Carcinoma (ATC): A Single Cancer Center’s Experience. Thyroid 27(S1):A-114, 2017. e-Pub 2017.
Iyer P, Cote GJ, Dadu R, Busaidy N, Ferrarotto R, Hess KR, Maria G, Subbiah V, Hofmann MC, Gross ND, Zafereo M, Cabanillas ME. Circulating BRAFV600E cell-free DNA detected by droplet digital PCR (ddPCR) as a biomarker in the management of anaplastic thyroid carcinoma (ATC) patients. Thyroid 27(S1):A-115, 2017. e-Pub 2017.
Puli OR, Danysh BP, Sinha DK, Cote GJ, Cabanillas ME, Hofmann MC. ETV5, an ETS family Transcription Factor, Drives Epithelial-to Mesenchymal Transition through expression of TWIST1 in Papillary Thyroid Cancer. Thyroid 27(S1):A-128, 2017. e-Pub 2017.
Danysh BP, Busaidy NL, Sinha DK, Evans KW, Moss TJ, Akcakanat A, Shaw K, Merik-Bernstam F, Cabanillas ME, Ringel MD, Shah M, Hofmann MC. BRAF Mutant Papillary Thyroid Cancer Cells with Concurrent Mutations Along the KRAS-RAC1 Axis Develop Resistance to BRAF(V600E)-Inhibitors and Are Associated with Increases in EMT Markers. Thyroid 27(S1):A74, 2017. e-Pub 2017. PMID: 29027880.
Danysh BP, Busaidy NL, Cabanillas ME, Hofmann MC. Activation of RAS-PI3K-RAC1 axis in BRAF(V600E)-inhibitor resistant papillary thyroid cancer cells (PTC) is associated with increased markers for invasion and extravasation. Proceedings of the 2017 MDACC Division of Internal Medicine Research Retreat, 2017. e-Pub 2017.
Puli OR, Danysh BP, Sinha DK, Hofmann MC. ETV5 Drives Cell Proliferation and TWIST1 Expression in Human Papillary Thyroid Cancer. Proceedings of the 2017 MDACC Division of Internal Medicine Research Retreat, 2017. e-Pub 2017.
Gandhi P, Danysh B, Parekh P, Farmaha J, Hofmann MC. The chromatin modifier BHC80 is a downregulator of NOTCH signaling in the mammalian testis. Proceedings of the 24th American Testis Workshop, Miami, FL, 2017. e-Pub 2017.
Gandhi P, Danysh BP, Parekh PA, Hofmann MC. BHC80 is a possible co-repressor of the NOTCH signaling pathway in Sertoli cells. Proceedings of the Texas Forum for Reproductive Sciences, 2017. e-Pub 2017.
Parekh P, Garcia TX, Waheeb R, Jain V, Gandhi P, Shetty G, Meistrich M, Hofmann MC. Regulation of Cyp26B1 expression in the spermatogonial stem cell niche. Andrology 5(Suppl):38, 2017. e-Pub 2017.
Parekh PA, Garcia TX, Waheeb R, Shetty G, Meistrich M, Hofmann MC. Regulation of Cyp26B1 expression in Sertoli cells. 50th Annual Gene Families and Isozymes Conference, 2016. e-Pub 2016.
Walker AK, Danysh BP, Christian DL, Remus JL, Hofmann MC, Dantzer R. Rapamycin inhibits antidepressant effects of leucine in lipopolysaccharide-treated mice. Proceedings of the Psychoneuroimmunology Research Society (PNIRS) Annual Meeting 57(Suppl), 2016. e-Pub 2016.
Hofmann MC. Regulation of GDNF expression in Sertoli cells. Proceedings of the IXX European Testis Workshop:16, 2016. e-Pub 2016.
Kow S, Hofmann MC, Garcia TX. Effect of cabozantinib on HGF/MET signaling in the testis. Proceedings of the Texas Forum for Reproductive Sciences:4, 2016. e-Pub 2016.
Parek P, Garcia TX, Sinha K, Hofmann MC. Repression of GDNF transcription by Jag1/Notch signaling in Sertoli Cells. Proceedings of the Texas Forum for Reproductive Sciences:57, 2016. e-Pub 2016.
Parekh P, Dadu R, Lai S, Cabanillas M, Hofmann MC. Markers for Targeted Immunotherapy of Anaplastic Thyroid Cancer. Proceedings of the Division of Internal Medicine Research Retreat:42, 2016. e-Pub 2016.
Danysh BP, Cabanillas ME, Hofmann MC. Long-term BRAF(V600E) inhibition results in a spontaneous KRAS(G12D) mutation and increased epithelial to mesenchymal transition (EMT) in papillary thyroid cancer cells (PTC). Proceedings of the MDACC Internal Medicine Research Retreat:40, 2016. e-Pub 2016.
Puli O, Danysh BP, Hoang NM, Hofmann MC. ETV5, an ETS family Transcription Factor, Drives Proliferation and Epithelial-to Mesenchymal Transition in Papillary Thyroid Cancer. Proceedings of the MDACC Internal Medicine Research Retreat:43, 2016. e-Pub 2016.
Danysh BP, Cabanillas ME, Hofmann MC. Long-term BRAF(V600E) inhibition results in a spontaneous KRAS(G12D) mutation and increased epithelial to mesenchymal transition (EMT) in papillary thyroid cancer cells (PTC). Cancer Research 76(14 (Supplement)):2933, 2016. e-Pub 2016.
Hofmann MC. Using Immunodetection Techniques for Assessing Male Fertility. Andrology, Proceedings of the ASA Annual Meeting 4(Suppl S1):25, 2016. e-Pub 2016.
Parekh PA, Garcia TX, Sinha K, Hofmann MC. The JAG1/NOTCH canonical effectors HES1 and HEY1 bind to the GDNF proximal promoter to repress its transcription in Sertoli cells. Andrology, Proceedings of the ASA Annual Meeting 4(Suppl S1):50, 2016. e-Pub 2016.
Garcia TX, Kow S, Hofmann MC. Activation of NOTCH signaling in Sertoli cells in vivo is dependent upon the presence of germ cells. Andrology, Proceedings of the ASA Annual Meeting 4(Suppl S1):61, 2016. e-Pub 2016.
Garcia TX, Kow S, Hofmann MC. Ablation of Rbpj rescues early pro-spermatogonia loss from ectopic activation of Notch signaling in mouse Sertoli cells. Andrology, Proceedings of the ASA Annual Meeting 4(Suppl S1):61, 2016. e-Pub 2016.
Danysh BP, Puli O, Sinha D, Hoang NM, Hofmann MC. Understanding Acquired Braf Inhibitor Resistance In Braf(V600e) Mutated Thyroid Cancers. 49th Annual Gene Families and Isozymes Conference, 2015. e-Pub 2015.
Puli O, Brian D, Hofmann MC. ETV5, an Ets Transcription Factor, is a Marker for Thyroid Cancer Progression. Thyroid, Proceedings of the 15th ITC and 85th ATA Meeting 25(1):A-18, 2015. e-Pub 2015.
Danysh BP, Cabanillas M, Hofmann MC. A Spontaneous KRAS(G12D) Mutation Following Long-Term Vemurafenib Treatment Drives Acquired BRAF Inhibitor (BRAFi) Resistance in a BRAF(V600E) PTC Cell Line. Thyroid, Proceedings of the 15th ITC and 85th ATA Meeting 25(1):A42-A43, 2015. e-Pub 2015.
Hofmann MC. Regulation of the testis stem cell niche by NOTCH signaling. The NOTCH Meeting IX, 2015. e-Pub 2015.
Hoang NM, Puli O, Danysh BP, Hofmann MC. ETV5, an Ets Family Transcription Factor, is a Marker for RAS-Dependent Papillary Thyroid Cancer. Thyroid, Proceedings of the 15th ITC and 85th ATA Meeting, 2015. e-Pub 2015.
Sinha D, Danysh BP, Hofmann MC. Mechanisms of Inhibitor Resistance in BRAFV600E Mutated Papillary Thyroid Cancer Cells. MDACC Summer Research Experience Meeting, 2015. e-Pub 2015.
Garcia TX, Kow S, Hofmann MC. GDNF Expression in Sertoli Cells is Modulated by the Activity of the HES/HEY Basic Helix-loop- helix Transcriptional Repressors. Proceedings of the Society for the Study of Reproduction Annual Meeting, 2015. e-Pub 2015.
Garcia T, Kow S, Hofmann MC. Regulation of the spermatogonial stem cell niche by NOTCH signaling. Proceedings of the Society for the Study of Reproduction Annual Meeting, 2015. e-Pub 2015.
Puli O, Hofmann MC. Role of ETV5 in B-RAF mutated thyroid cancer. MDACC Division of Internal Medicine Research Retreat, 2015. e-Pub 2015.
Danysh BP, Cabanillas M, Hofmann MC. Acquired BRAF Inhibitor (BRAFi) Resistance Drives EMT in Papillary Thyroid Cancer (PTC). MDACC Division of Internal Medicine Research Retreat, 2015. e-Pub 2015.
Gandhi P, Garcia TX, Danysh BP, Hofmann MC. Cell-cell contact between germ line stem cells and niche cells is required for stem cell homeostasis. MDACC Division of Internal Medicine Research Retreat, 2015. e-Pub 2015.
Kow S, Hofmann MC, Garcia TX. Effect of cabozantinib on HGF-MET signaling in the testis. MDACC Division of Internal Medicine Research Retreat, 2015. e-Pub 2015.
Hofmann MC. Regulation of male germ line stem cell homeostasis. Texas Forum for the Reproductive Sciences, 2015. e-Pub 2015.
Garcia T, Kow S, Gandhi P, Danysh BP, Hofmann MC. Notch signaling in Sertoli cells. Andrology, Abstracts from the ASA 40th Annual Meeting 3(Suppl 1), 2015. e-Pub 2015.
Gandhi P, Garcia TX, Danysh, BP, Hofmann MC. Physical interaction between spermatogonial stem cells and Sertoli cells is required for control of germ cell numbers. Texas Forum for the Reproductive Sciences, 2015. e-Pub 2015.
Garcia TX, Hofmann MC. Ablation of Rbpj rescues early pro-spermatogonia loss from ectopic activation of Notch signaling in mouse Sertoli cells. 2015 Texas Forum for Reproductive Sciences, 2015. e-Pub 2015.
Parekh P, Garcia T, Hofmann MC. Improving Sperm Output in Oligospermia?. 48 Annual Conference on Genes Family and Isozymes Conference, 2014. e-Pub 2014.
Hofmann MC. Regulation of Germ Line Stem Cell Homeostasis. V ISABR, 2014. e-Pub 2014.
Hofmann MC. Mechanisms Controlling the Male Germ Line Stem Cell Niche. Proceedings of the SBCC 2014, 2014. e-Pub 2014.
Garcia TX, Farmaha J, Kow S, Hofmann MC. NOTCH signaling regulates the testis stem cell niche. Gordon Research Conference on Mammalian Reproduction, Colby Sawyer College, 2014. e-Pub 2014.
Hofmann MC. Notch Signaling in the Male Germ Line Stem Cell Niche. Endocrine Reviews (Proceedings of the ENDO Society 96th Annual Meeting) 35(3):Suppl, 2014. e-Pub 2014.
Garcia TX, Hofmann MC. RBPJκ in Sertoli cells is required for the proper regulation of the testis stem cell niche. Texas Forum for Reproductive Sciences (TFRS) XX Annual Meeting, 2014. e-Pub 2014.
Garcia TX, Kow S, Hofmann MC. Notch Signaling in the Perinatal Germ Cell Niche. Endocrine Reviews (Proceedings of the ENDO Society 96th Annual Meeting), 2013. e-Pub 2013.
Danysh BP, Cabanillas M, Hofmann MC. Effects of activated estrogen receptors on acquired BRAF inhibitor resistance in papillary thyroid cancer (PTC). American Thyroid 6 Association 83rd Annual Meeting, San Juan, PR. Thyroid 23(S1):A-25 #35, 2013. e-Pub 2013.
Danysh BP, Cabanillas M, Hofmann MC. Effects of activated estrogen receptors on acquired BRAF inhibitor resistance in papillary thyroid cancer (PTC). Division of Internal Medicine Research Retreat, MDACC, 2013. e-Pub 2013.
Kaur-Farmaha J, Shkumatov A, Fields C, Simon L, Cooke P, Hofmann MC. Generation of capillary-like structures from mouse primary spermatogonial stem cells in defined three dimensional collagen gels. Division of Internal Medicine Research Retreat, MDACC, 2013. e-Pub 2013.
Garcia TX, Hofmann MC. Disruption of NOTCH signaling in Sertoli cells induces testicular germ cell hyperplasia. Division of Internal Medicine Research Retreat, MDACC, 2013. e-Pub 2013.
Tang L, Bondareva A, Hofmann MC, Dobrinski I. Characterization of Ubiquitin Carboxyl-terminal Hydrolase L1 in Mouse Spermatogonia. 38th Annual Meeting of the American Society of Andrology (ASA), San Antonio, TX. Andrology 1(Suppl 2), 2013. e-Pub 2013.
Jaspreet K, Hofmann MC. The extracellular matrix protein NOV mediates vasculogenesis from mouse primary spermatogonial stem cells. Texas Forum for Reproductive Sciences (TFRS) 19th Annual Meeting, 2013. e-Pub 2013.
Lucas BEG, Meling D, Hofmann MC. MEHP Impairs Spermatogonial Stem Cell Self-Renewal. Illinois Symposium for Reproductive Medicine (ISRS), 2012. e-Pub 2012.
Kaur-Farmaha J, Shkumatov A, Tsay C Fields C, Simon L, Cooke P, Hofmann MC. Generation of capillary-like structures from mouse primary spermatogonial stem cells in defined three-dimensional collagen gels. 45th Annual Meeting of the Society for the Study of Reproduction (SSR) 87(Suppl 1), 2012. e-Pub 2012.
Hofmann MC, Garcia T. Notch Signaling as Modulator of Gonocyte Fate in the Perinatal Testis. 14th International Congress of Histochemistry and Cytochemistry, 2012. e-Pub 2012.
Garcia T, Costa GMJ, Franca LR, Hofmann MC. Silver nanoparticles affect Leydig cell function in vivo. 94th Annual Meeting of the Endocrine Society, 2012. e-Pub 2012.
Lucas B, Hofmann MC. MEHP reduces maintenance and proliferation of primary spermatogonial stem cells in vitro. 37th Annual Meeting of the American Society of Andrology (ASA) 33(Suppl 2), 2012. e-Pub 2012.
Garcia T, Hofmann MC. Constitutive expression of activated NOTCH1 in Sertoli cells leads to a loss of GDNF and CYP26B1 expression, and premature gonocyte differentiation. 37th Annual Meeting of the American Society of Andrology (ASA) 33(Suppl 2), 2012. e-Pub 2012.
Garcia T, Costa G, Franca LR, Hofmann MC. Intravenous administration of silver nanoparticles in male mice alters Leydig cell function and increases serum testosterone, but does not perturb spermatogenesis. 51st Annual Meeting of the American Society of Toxicology 51:16, 2012. e-Pub 2012.
Garcia T, Meling D, Hofmann MC. Notch signaling in perinatal Sertoli cells modulates germ cell fate. 46th Annual Conference on Gene Families and Isozymes, 2012. e-Pub 2012.
Campos PHA, Costa MJ, Lacerda SM, Rezende-Neto JV, Paula AM, Garcia AM, Hofmann MC, Franca LR. The spermatogonial stem cell niche is not dependent on Leydig cells in the collared peccary (Tayassu tacaju). XXI Testis Workshop, 2011. e-Pub 2011.
Garcia T, Li G, Hofmann MC. A role for Notch signaling at male germ cell meiosis?. XXI Testis Workshop, 2011. e-Pub 2011.
Lucas B, Hofmann MC. MEHP reduces Fos expression in freshly isolated spermatogonial stem cells. 2nd Illinois Symposium for Reproductive Sciences (ISRS), 2011. e-Pub 2011.
Kaur J, Tsay C, Shkumatov A, Fields C, Kuhlenschmidt MS, Hofmann MC. In vitro differentiation of mouse primary spermatogonial stem cells into endothelial cells using growth factors and novel extracellular matrix proteins in a three-dimensional collagen gel. 2nd Illinois Symposium for Reproductive Sciences (ISRS), 2011. e-Pub 2011.
Garcia T, Hofmann MC. Notch signaling in fetal Sertoli cells regulates gonocyte differentiation. 2nd Illinois Symposium for Reproductive Sciences (IRSR), 2011. e-Pub 2011.
Waheeb R, Schaefer K, ElamrawiІ G, Elbawab I, Nosier W, Hofmann MC. Characterization and in-vitro propagation of canine stem/progenitor spermatogonia. American Society of Andrology (ASA) 36th Annual Meeting 32(Suppl 1), 2011. e-Pub 2011.
Garcia T, Li G, Hofmann MC. Overactivation of Notch signaling in fetal Sertoli cells results in dysregulation of germ cells, which results in germ cell apoptosis and Sertoli-only phenotype. 44th Annual Meeting of the Society for the Study of Reproduction (SSR) 85(Suppl 1), 2011. e-Pub 2011.
Hofmann MC, Garcia T. Role of NOTCH signaling in the male germ line. 44th Annual Meeting of the Society for the Study of Reproduction (SSR) 85(Suppl 1), 2011. e-Pub 2011.
Cooke PS, Simon L, Ekman GC, Hofmann MC. Differentiation of stem/progenitor spermatogonia into prostatic epithelium: direct or indirect?. 43rd Annual Meeting of the Society for the Study of Reproduction (SSR), Milwaukee, WI. Biology of Reproduction 83(Suppl 1), 2010. e-Pub 2010.
Shkumatov A, Fields C, Carnes K, Hofmann MC. Use of spermatogonial stem cells for in vitro vasculogenesis. 4th Institute for Genomic Biology Annual Symposium, UIUC, 2010. e-Pub 2010.
Simon L, Hofmann MC, Cooke PS. Mechanism of differentiation of stem/progenitor spermatogonia into prostatic epithelium. 11th Annual Biomedical Research Symposium, Tuskegee University, 2010. e-Pub 2010.
Garcia T, Li G, Hofmann MC. Role of the bhlh transcription factor heyl in male germ cell meiosis. 44th Annual Conference on Gene Families and Isozymes, Providenciales, Turks, and Caicos 44, 2010. e-Pub 2010.
Segatelli TM, Garcia T, Franca LR, Hofmann MC. Delta-like homolog I (Dlk1) is a novel marker for prepubertal Sertoli cells. 3rd International Symposium on Animal Reproductive Biology (ISABR 2010), 2010. e-Pub 2010.
SMSN L, Costa GMJ, Campos PHA, Hofmann MC, Franca LR. Investigation of Potential Specific Markers for Spermatogonial Stem Cells in the Nile Tilapia (Oreochromis niloticus). 3rd International Symposium on Animal Reproductive Biology (ISABR 2010), 2010. e-Pub 2010.
Hofmann MC. Human Spermatogonial Stem Cells. 7th Copenhagen Workshop on Testicular Carcinoma in Situ and Germ Cell Cancer, 2010. e-Pub 2010.
Hofmann MC. Spermatogonial stem cell isolation, culture, and analysis in vitro. 35th American Society of Andrology (ASA) Annual Meeting, Houston, TX. Journal of Andrology 31(Suppl 1), 2010. e-Pub 2010.
Hofmann MC. Stem Cells Models for Vasculogenesis in 3D Scaffolds. EBICS Partnership 1st Annual Meeting, UIUC, 2010. e-Pub 2010.
Garcia T, Hofmann MC. Reporter mice for stem cell isolation. 35th American Society of Andrology (ASA) Annual Meeting, Houston, TX. Journal of Andrology 31(Suppl1), 2010. e-Pub 2010.
Garcia T, Hofmann MC. HEYL and NICD3 co-localize to the XY body of mouse pachytene spermatocytes: possible role for Notch signaling in male germ cell meiosis. 1st Illinois Symposium for Reproductive Sciences (ISRS), 2010. e-Pub 2010.
Tang L, Hofmann MC, Dobrinski I. Characterization of Ubiquitin Carboxyl-terminal Hydrolase L1 in the Fate Determination of Spermatogonia. 43rd Annual Meeting of the Society for the Study of Reproduction (SSR), Milwaukee, WI. Biology of Reproduction 83(Suppl 1), 2010. e-Pub 2010.
Lucas BE, Joshi N, Hofmann MC. Phthalates decrease spermatogonial stem cell proliferation by altering GDNF signaling. XX North American Testis Workshop 49:315, 2010. e-Pub 2010.
Lucas BE, Joshi N, Hofmann MC. Phthalates decrease spermatogonial stem cell proliferation by altering GDNF signaling. XX North American Testis Workshop, 2009. e-Pub 2009.
Fields CJ, Simon L, Carnes K, Ferguson N, Cooke P, Hofmann MC. Vascular trans-differentiation of spermatogonial stem cells. XX North American Testis Workshop, 2009. e-Pub 2009.
Lucas B, Fields CJ, Braydich-Stolle L, Joshi N, Buyns P, Hofmann MC. Alteration of Signaling Pathways in Spermatogonial Stem Cells by Environmental Toxicants. 2nd Workshop on Male Reproductive Biology, 2009. e-Pub 2009.
Simon L, Fields C, Carnes K, Ferguson N, Hess RA, Cooke PS, Hofmann MC. Differentiation of Spermatogonial Stem Cells into Prostate and Other Somatic Tissues. 2nd Workshop on Male Reproductive Biology, 2009. e-Pub 2009.
Hofmann MC. Molecular mechanisms regulating spermatogonial stem cells within their niche. XXIV Annual Meeting of the Brazilian Federation of the Societies of Experimental Biology, 2009. e-Pub 2009.
Waheeb R, Carnes K, Simon L, Hess R, Hofmann MC. Isolation, characterization and culture of canine spermatogonial stem cells. 30th Annual Northwestern Mini-Symposium on Reproductive Biology, 2009. e-Pub 2009.
Garcia T, Hofmann MC. The role of Notch signaling in the self-renewal and differentiation fate of mouse spermatogonial stem cells. 30th Annual Northwestern Mini-Symposium on Reproductive Biology, 2009. e-Pub 2009.
Fields CJ, Simon L, Carnes K, Ferguson N, Cooke PS, Hofmann MC. Differentiation of Spermatogonial Stem Cells into Capillaries. 43rd Annual Conference on Gene Families and Isozymes (GFI) 43:22, 2009. e-Pub 2009.
Simon L, Murphy KM, Murphy TL, Hess RA, Cooke PS, Hofmann MC. Regulation of Spermatogonial Stem Cells Homing and Retention. Molecular Andrology International Workshop, 2009. e-Pub 2009.
Waheeb R, Carnes K, Simon L, Hess R, Hofmann MC. Isolation and characterization of canine spermatogonial stem cells. 3rd Institute for Genomic Biology Annual Symposium, UIUC, 2009. e-Pub 2009.
Simon L, Ekman GC, Carnes K, Zhang Z, Murphy T Murphy KM, Hess RA, Cooke PS, Hofmann MC. The transcription factor Etv5 regulates Sertoli cell chemokines involved in maintaining spermatogonial stem cells in the niche. 3rd Institute for Genomic Biology Annual Symposium, UIUC, 2009. e-Pub 2009.
Hofmann MC. Signal integration within the spermatogonial stem cell niche. 41st Annual Meeting of the Society for the Study of Reproduction (SSR) 78(Suppl 1):234, 2009. e-Pub 2009.
Fields C, Simon L, Carnes K, Ferguson N, Cooke P, Hofmann MC. Identification of determinants involved in vascular trans-differentiation of spermatogonial stem cells. 21st Cell and Molecular Biology & Molecular Biophysics Symposium (MCB-MB), UIUC, 2008. e-Pub 2008.
Simon L, Ekman GC, Kostereva N, Zhang Z, Hess RA, Hofmann MC, Cooke P. Trans-differentiation of spermatogonial stem cells into reproductive and non-reproductive tissues of all three germ layers. 29th Annual Northwestern Mini-Symposium on Reproductive Biology, 2008. e-Pub 2008.
Lucas B, Braydich-Stolle LK, Lee T, Hussain SM, Hofmann MC. Toxicity of silver nanoparticles in male germ-line stem cells. 42nd Annual Conference on Gene Families and Isozymes (GFI), 2008. e-Pub 2008.
Kong HJ, Chu C, Schmidt J, Carnes K, Zhang Z, Hofmann MC. Synthetic stem cell niche for in vitro spermatogonial stem cell culture. American Institute for Chemical Engineers (AIChE) Annual Meeting, Session: Stem cells in Tissue Engineering II, 2008. e-Pub 2008.
Braydich-Stolle L, Lucas B, Lee T, Schlager J, Hussain S, Hofmann MC. Silver nanoparticles disrupt GDNF signaling in male germ-line stem cells. 47th Annual Meeting of the American Society of Toxicology 47, 2008. e-Pub 2008.
Simon L, Murphy KM, Murphy TL, Hess RA, Cooke PS, Hofmann MC. The transcription factor ETV5 regulates Sertoli cell chemokines that maintain spermatogonial stem cells in the stem cell niche. 33rd American Society of Andrology (ASA) Annual Meeting, Albuquerque, NM. Journal of Andrology 29(Suppl 1), 2008. e-Pub 2008.
Lucas BE, Joshi N, Hofmann MC. Phthalates decrease spermatogonial stem cell proliferation by altering GDNF signaling. 29th Annual Northwestern Mini- Symposium on Reproductive Biology, 2008. e-Pub 2008.
Hofmann MC. Spermatogonial stem cells in and out of their niche. 2nd International Symposium on Animal Biology of Reproduction (ISABR), 2008. e-Pub 2008.
Kokkinaki M, Hofmann MC, Lee TL, He Z, Jiang J, Golestaneh N, Chan WY, Dym M. Isolation and characterization of GFRa-1 positive spermatogonial stem cells in the immature mouse. 47th ASCB Meeting, 2007. e-Pub 2007.
Kostereva N, Carnes K, Hofmann MC. Regulation of apoptosis in spermatogonial stem cells by Jagged1 and GDNF in vitro. XIX North American Testis Workshop, 2007. e-Pub 2007.
Schlesser H, Hofmann MC, Carnes K, Murphy KM, Hess RA, Cooke PS. Time course of spermatogonial stem cell loss in ERM knockout mice: critical neonatal effects of ERM. XIX North American Testis Workshop, 2007. e-Pub 2007.
Cooke P, Schlesser H, Tyagi G, Simon L, Carnes K, Hofmann MC, Murphy K, Hess R. Ets-related molecule (ERM) and spermatogonial stem cell self-renewal. Keystone Symposia on Stem Cells, 2007. e-Pub 2007.
Hofmann MC, Kostereva N, Carnes K. Role of NOTCH signaling in the mammalian germline. 41st Conference on Gene Families and Isozymes 41:11, 2007. e-Pub 2007.
Kostereva N, Carnes K, Lucas B, Joshi N, Hofmann MC. Regulation of p53 expression in spermatogonia by Notch1/Jagged1 in vitro. 28th Annual Northwestern Symposium on Reproductive Biology, 2007. e-Pub 2007.
Tyagi G, Carnes K, Simon L, Murphy KM, Hofmann MC, Hess RA, Cooke PS. Neonatal role of Ets-related molecule (ERM) in spermatogonial stem cell (SSCs). XIX North American Testis Workshop, 2007. e-Pub 2007.
Kostereva N, Dym M, Hofmann MC. Effects of Jagged1 and GDNF on mouse spermatogonial stem cells in vitro. American Society of Andrology 31st Annual Meeting 27(Suppl 1):74, 2006. e-Pub 2006.
Carroll M, Hofmann MC. Differential expression of molecular markers during osteogenesis in viv. Ohio Academy of Sciences Annual Meeting, 2006. e-Pub 2006.
Calhoun J, Check M, Blubaugh E, Tomcsak M, Johnson J, Hofmann MC. Effects of functionalized TiO2 nanoparticles on cellular apoptosis and formation of reactive oxygen species. Ohio Academy of Sciences Annual Meeting, 2006. e-Pub 2006.
Carnes T, Kostereva N, Luo J, Dym M, Dobrinski I, Hofmann MC. Transplantation of immortalized germ cells. Ohio Academy of Sciences Annual Meeting, 2006. e-Pub 2006.
Braydich-Stolle L, Hussain S, Schlager J, Hofmann MC. Effect of silver nanoparticles on Src activity in C18-4 cells. Society of Toxicology 45th Annual Meeting 45:7, 2006. e-Pub 2006.
Braydich-Stolle L, Roddy MA, Dym M, Hofmann MC. GDNF signals through Src-dependent and Src-independent mechanisms in male germ-line stem cells. American Society of Andrology 31st Annual Meeting 27(Suppl 1):48, 2006. e-Pub 2006.
Braydich-Stolle L, Dym M, Hofmann MC. Role of glial cell line-derived neurotrophic factor (GDNF) in germ-line stem cell fate. American Society of Andrology 30th Annual Meeting, Seattle, WA. Journal of Andrology 26(Suppl 1), 2005. e-Pub 2005.
Braydich-Stolle L, Hussain S, Schlager J, Hofmann MC. A germ-line stem cell line as a model for evaluating the cytotoxicity of nanoparticles in vitro. Society of Toxicology 44th Annual Meeting 44:331, 2005. e-Pub 2005.
Braydich-Stolle L, Dym M, Hofmann MC. Signaling pathways induced by glial cell line-derived neurotrophic factor (GDNF) in spermatogonial stem cells; role of Src kinase. American Society of Andrology 29th Annual Meeting 25(Suppl 1):30, 2004. e-Pub 2004.
Braydich-Stolle L, Dym M, Hofmann MC. Role of glial cell line-derived neurotrophic factor (GDNF) in germ-line stem cell fate. 38th Conference on Isozymes and Gene Families 38:26, 2004. e-Pub 2004.
Dym M, Hofmann MC, Feng L. Male germ line stem cells: A novel stem cell line. From Stem Cells to Therapy. Keystone Symposium on Development, 2003. e-Pub 2003.
Dym M, Hofmann MC. Novel aspects of spermatogonial stem cells. 37th Conference on Isozymes and Gene Families 37:34, 2003. e-Pub 2003.
Hofmann MC, Braydich-Stolle L, Li XQ, Dym M. Microarray analysis of GDNF-responsive genes in type A spermatogonia. Functional Genomics of Male Reproduction, XVIth American Testis Workshop 24(Suppl 1):125, 2003. e-Pub 2003.
Li XQ, Dym M, Hofmann MC. Isolation of murine testis stem cells based on cell surface phenotype. Proceedings of the 12th European Workshop on Molecular and Cellular Endocrinology of the Testis 2:7, 2002. e-Pub 2002.
Li XQ, Braydich-Stolle L, Dym M, Hofmann MC. Profiling of gene expression in GDNF-responsive type A spermatogonia. 36th Conference on Isozymes and Gene Families 36:24, 2002. e-Pub 2002.
Dettin LE, Ravindranath N, Hofmann MC, Dym M. Profiling of gene expression in a putative spermatogonial cell line. Proceedings of the 12th European Workshop on Molecular and Cellular Endocrinology of the Testis 2:4, 2002. e-Pub 2002.
Hofmann MC, Johnson E, Dettin L, Dirami G, Dym M. Establishment of a germ cell line expressing the GFRα-1 membrane receptor. VII International Congress of Andrology 22(Suppl. 1):155, 2001. e-Pub 2001.
Feng L, Chen Y, Reijo Pera R, Hofmann MC, Dym M. Telomerase- immortalized spermatogonial cell lines. VII International Congress of Andrology 22(Suppl 1):125, 2001. e-Pub 2001.
Li XQ, Dym M, Hofmann MC. Immunomagnetic bead isolation of murine testis stem cell. 35th Conference on Isozymes and Gene Families 35:42, 2001. e-Pub 2001.
Billotte WG, Dumas K, Hofmann MC. Stress-induced signaling pathways in mouse preosteblasts. Proceedings of the 38th Rocky Mountain Bioengineering Symposium, 2001. e-Pub 2001.
Hofmann MC, van der Wee K, Johnson E, Dirami G, Dettin L, Dym M. Establishment and characterization of a mouse spermatogonial stem cell line. Regulatory Mechanisms of Testicular Cells Differentiation, XVIth Serono Symposium on Spermatogenesis, 2001. e-Pub 2001.
Hofmann MC, van der Wee K, Dirami G, Dym M. Characterization of immortalized germ cells and Sertoli cells using the GFRα-receptor family of proteins. 34th Conference on Isozymes and Gene Families 34:35, 2000. e-Pub 2000.
Billotte WG, Kapostasy J, Hofmann MC. Influence of shear stress on the localization of cytoskeleton-associated proteins in human bone stem cells. American Society for Bone and Mineral Research, 22nd Annual Meeting 15(Suppl 1):445, 2000. e-Pub 2000.
van der Wee KS, Hofmann MC. Involvement of HGF/c-met in the formation of mouse testicular tubules. The Testis: From Stem Cell to Sperm Function, XVth Serono Symposium on Spermatogenesis, 1999. e-Pub 1999.
van der Wee KS, Dargart J, Hofmann MC. Immunomagnetic isolation and long-term survival of mouse type A spermatogonia. 32nd Annual Meeting of the Society for the Study of Reproduction (SSR) 60(Suppl 1):257, 1999. e-Pub 1999.
van der Wee KS, Dargart J, Hofmann MC. Establishment and characterization of in vitro seminiferous tubules for the long-term culture of mouse spermatogonia. First Meeting on Gametogenesis, Cold Spring Harbor Laboratory, 1998. e-Pub 1998.
Van der Wee K, Hofmann MC. Development of an in vitro seminiferous tubule model. Annual Midwest Developmental Biology Meeting, 1997. e-Pub 1997.
Hoeben E, Hofmann MC, Millan JL, Verhoeven G. Mouse peritubular cells immortalized using the SV40 Large T antigen produce P-Mod-S- like activity. 9th European Workshop on the Molecular and Cellular Endocrinology of the Testis, 1996. e-Pub 1996.
Weissig H, Hofmann MC, Millan JL. A family of zinc finger proteins is expressed during spermatogenesis. Cellular and Molecular Regulation of Testicular Cells, XIIIth Serono Symposium on Spermatogenesis, 1995. e-Pub 1995.
Hofmann MC, Millan JL. Establishment of Murine Meiotic Germ Cell Lines and Their Use to Study Spermatogenesis in vitro. Cellular and Molecular Regulation of Testicular Cells, XIIIth Serono Symposium on Spermatogenesis, 1995. e-Pub 1995.
Hofmann MC, Millan JL. Immortalization of primary spermatocytes, Sertoli, peritubular and Leydig cells using the SV40 Large T antigen. The Male Germ Cell: From Spermatogonium to Fertilization, XIth Serono Symposium on Spermatogenesis, 1991. e-Pub 1991.
Hofmann MC, Jeltsch W, Brecher J, Walt H. Alkaline phosphatase isozymes in human testicular germ cell tumors, precancerous stages and three related cell lines. Alkaline Phosphatase Symposium, 1989. e-Pub 1989.
Hofmann MC, Brecher J, Walt H. Effects of dibutyryl-cAMP on alkaline phosphatase expression in a cell line from a testicular germ cell tumor. Alkaline Phosphatase Symposium, 1989. e-Pub 1989.

Book Chapters

Yarmand, R, Grubbs, EG, Hofmann, M. Thyroid C-Cell Biology and Oncogenic Transformation. In: Medullary Thyroid Carcinoma, 51-91, 2025.
Iyer, PC, Srour, S, Hofmann, M, Cabanillas, ME. Current Trends in Treatment and New Generation of Trials in Thyroid Cancer. In: Practical Management of Thyroid Cancer. Springer, 307-324, 2024.
Cabanillas ME, Schweppe RE, Dadu R, Cote G, Beadnell TC, Hofmann MC. Translational Research and Genomics Driven Trials in Thyroid Cancer. In: Practical Management of Thyroid Cancer. Springer, 319-338, 2018.
Cabanillas ME, Schweppe RE, Dadu R, Cote GJ, Beadnell TC, Hofmann MC. Future Developments and Directions for Research in Thyroid Cancer. In: Practical Management of Thyroid Cancer: A Multidisciplinary Approach. 2. Springer, 319-338, 2017.
Cote G, Bagheri-Yarmand R, Hofmann MC, Gagel RF. Molecular Mechanisms of Disease: The RET Proto-Oncogene. In: Medullary Thyroid Cancer. Springer International Publishing, 47-63, 2016.
Hofmann MC. Stem Cells and Nanomaterials. In: Nanomaterial (Adv Exp Med Biol). Springer, 255-275, 2014.
Simon L, Hofmann MC, Cooke P. Spermatogonial stem cells-an alternative of pluripotent stem cells for regenerative medicine. In: Tissue Regeneration. In Tech, 2011.
Hofmann MC, Braydich-Stolle LK. Neurotrophic Factors in the Development of the Postnatal Male Germ Line. In: The Y Chromosome and Male Germ Cell Biology in Health and Diseases in the Post-Genomic Era. World Scientific Publishing, 149-184, 2007.
Hofmann MC, Dym M. Long Term Cultures of Mammallian Spermatogonia. In: Sertoli Cell Biology. Academic Press, 449-470, 2005.
Hofmann MC, Abramian D, Weissig H, Richardson LL, Millan JL. Establishment of meiotic germ cell lines and their use to study spermatogenesis in vitro. In: Cellular and Molecular Regulation of Testicular Cells. Springer Verlag, 45-64, 1996.

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CV information above last modified August 17, 2026

Marie-Claude C Hofmann, Ph.D.

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Marie-Claude C Hofmann, Ph.D.

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Education & Training

Degree-Granting Education

Postgraduate Training

Experience & Service

Faculty Academic Appointments

Intramural Institutional Committee Activities

Editorial Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

Local Presentations

Regional Presentations

National Presentations

International Presentations

Formal Peers

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Review Articles

Other Articles

Editorials

Abstracts

Book Chapters

Patient Reviews

Request an Appointment

Related Links

Hofmann Laboratory

Endocrine Neoplasia & Hormonal Disorders department

Internal Medicine division

Clinical Trials

Help #EndCancer

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