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Marie-Claude C Hofmann, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

The Hofmann Laboratory

  •   Regulation of signaling pathways within the stem cell niche
  •   Role of NOTCH signaling and its interactions with FGF2 and TGFβ pathways
  •   Effects of environmental toxicants on the germ line and the behavior of thyroid cancer cells
  •   Effects of targeted therapies on male fertility
  •   Mechanisms of acquired resistance to tyrosine kinase inhibitors


 

Office Address

The University of Texas MD Anderson Cancer Center
2121 Holcombe Boulevard
Unit Number: 1105
Houston, TX 77030
Room Number: IBT8.816

Education & Training

Degree-Granting Education

1988 University of Lausanne, Lausanne, Switzerland, PHD, Biological Sciences
1977 University of Lausanne, Lausanne, Switzerland, BS, Biological Sciences

Postgraduate Training

1/1989-6/1995 Postdoctoral Fellowship, Cell and Molecular Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA, Dr. Jose Luis Millan

Honors and Awards

2010-2014 Member, NIH CSR-CMIR study section
2010-2011 Killam Visiting Research Scholar Award, University of Calgary, AB, Canada
2010 Dr. Gordon and Mrs. Helen Kruger Research Excellence Award, College of Veterinary Medicine, University of Illinois at Urbana-Champaign
2007-2013 NIH Independent Scientist Award (K02 HD054607)
2005 George E. Nolan Award for Excellence in Research (Sigma Xi Research Society)
1993-1995 National Research Service Award, National Cancer Institute, USA

Selected Publications

Peer-Reviewed Original Research Articles

1. Garcia TX, Costa GM, Franca LR, Hofmann MC. Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol 45C. e-Pub 1/2014. PMID: 24447867.
2. Gabrielson NP, Desai AV, Mahadik B, Hofmann MC, Kenis PJ, Harley BA. Cell-Laden Hydrogels in Integrated Microfluidic Devices for Long-Term Cell Culture and Tubulogenesis Assays. Small 9(18):3076-81, 9/23/2013. e-Pub 3/7/2013. PMID: 23468408.
3. Garcia TX, Hofmann MC. NOTCH signaling in Sertoli cells regulates gonocyte fate. Cell Cycle 12(16):2538-45, 8/15/2013. e-Pub 7/10/2013. PMID: 23907117.
4. Garcia TX, DeFalco T, Capel B, Hofmann MC. Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. Dev Biol 377(1):188-201, 5/1/2013. e-Pub 2/4/2013. PMCID: PMC3630254.
5. Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA, Jimenez C. Bone Metastases and Skeletal Related Events in Patients with Malignant Pheochromocytoma and Sympathetic Paraganglioma. J Clin Endocrinol Metab 98(4):1492-7, 4/2013. e-Pub 2/22/2013. PMID: 23436918.
6. Lucas BE, Fields C, Joshi N, Hofmann MC. Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia. Toxicology 299(1):10-9, 9/2012. e-Pub 4/2012. PMCID: PMC3377775.
7. Garcia T, Hofmann MC. Isolation of undifferentiated and early differentiating type A spermatogonia from Pou5f1-GFP reporter mice. Methods Mol Biol 825:31-44, 2012. PMCID: PMC3314309.
8. Costa GM, Avelar GF, Rezende-Neto JV, Campos-Junior PH, Lacerda SM, Andrade BS, Thomé RG, Hofmann MC, Franca LR. Spermatogonial stem cell markers and niche in equids. PLoS One 7(8):e44091, 2012. e-Pub 8/28/2012. PMCID: PMC3429436.
9. Campos-Junior PH, Costa GM, Lacerda SM, Rezende-Neto JV, de Paula AM, Hofmann MC, de França LR. The spermatogonial stem cell niche in the collared peccary (Tayassu tajacu). Biol Reprod 86(5):155, 1-10, 2012. e-Pub 5/17/2012. PMCID: PMC3364928.
10. Waheeb R, Hofmann MC. Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl 34(4 Pt 2):e296-305; discussion e305, 8/2011. PMCID: PMC3146023.
11. Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS, Hofmann MC. ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells 28(10):1882-92, 10/2010. PMCID: PMC3109872.
12. Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC. Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci 116(2):577-89, 8/2010. e-Pub 5/2010. PMCID: PMC2905406.
13. Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction 139(6):1011-20, 6/2010. e-Pub 4/6/2010. PMCID: PMC2906712.
14. Morrow CM, Tyagi G, Simon L, Carnes K, Murphy KM, Cooke PS, Hofmann MC, Hess RA. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod 81(5):871-9, 11/2009. e-Pub 7/1/2009. PMCID: PMC2770019.
15. Tyagi G, Carnes K, Morrow C, Kostereva NV, Ekman GC, Meling DD, Hostetler C, Griswold M, Murphy KM, Hess RA, Hofmann MC, Cooke PS. Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod 81(2):258-66, 8/2009. e-Pub 4/15/2009. PMCID: PMC2849825.
16. Simon L, Ekman GC, Kostereva N, Zhang Z, Hess RA, Hofmann MC, Cooke PS. Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells 27(7):1666-75, 7/2009. PMCID: PMC2904909.
17. Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis. Biol Reprod 80(4):707-17, 4/2009. e-Pub 12/2008. PMID: 19109221.
18. Lucas B, Fields C, Hofmann MC. Signaling pathways in spermatogonial stem cells and their disruption by toxicants. Birth Defects Res C Embryo Today 87(1):35-42, 3/2009. PMCID: PMC2906709.
19. Chu C, Schmidt JJ, Carnes K, Zhang Z, Kong HJ, Hofmann MC. Three-dimensional synthetic niche components to control germ cell proliferation. Tissue Eng Part A 15(2):255-62, 2/2009. PMCID: PMC3120087.
20. Liu CF, Barsoum I, Gupta R, Hofmann MC, Yao HH. Stem cell potential of the mammalian gonad. Front Biosci (Elite Ed) 1:510-8, 2009. e-Pub 6/1/2009. PMCID: PMC2902374.
21. Kostereva N, Hofmann MC. Regulation of the spermatogonial stem cell niche. Reprod Domest Anim 43 Suppl 2:386-92, 7/2008. PMCID: PMC2904914.
22. Hofmann MC. Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol 288(1-2):95-103, 6/2008. e-Pub 4/2008. PMCID: PMC2491722.
23. Schlesser HN, Simon L, Hofmann MC, Murphy KM, Murphy T, Hess RA, Cooke PS. Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod 78(3):483-9, 3/2008. e-Pub 11/2007. PMCID: PMC2911230.
24. He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells 26(1):266-78, 1/2008. e-Pub 10/2007. PMCID: PMC2905627.
25. Morrow CM, Hostetler CE, Griswold MD, Hofmann MC, Murphy KM, Cooke PS, Hess RA. ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege. Ann N Y Acad Sci 1120:144-51, 12/2007. e-Pub 10/2/2007. PMCID: PMC2733827.
26. He Z, Jiang J, Hofmann MC, Dym M. Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod 77(4):723-33, 10/2007. e-Pub 7/2007. PMCID: PMC2911237.
27. Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC. Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol 304(1):34-45, 4/2007. e-Pub 12/2006. PMCID: PMC2077853.
28. Hess RA, Cooke PS, Hofmann MC, Murphy KM. Mechanistic insights into the regulation of the spermatogonial stem cell niche. Cell Cycle 5(11):1164-70, 6/2006. e-Pub 6/2006. PMCID: PMC2909758.
29. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88(2):412-9, 12/2005. e-Pub 7/2005. PMCID: PMC2911231.
30. Braydich-Stolle L, Nolan C, Dym M, Hofmann MC. Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Ann N Y Acad Sci 1061:94-9, 12/2005. PMCID: PMC2904487.
31. Chen C, Ouyang W, Grigura V, Zhou Q, Carnes K, Lim H, Zhao GQ, Arber S, Kurpios N, Murphy TL, Cheng AM, Hassell JA, Chandrashekar V, Hofmann MC, Hess RA, Murphy KM. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature 436(7053):1030-4, 8/2005. PMCID: PMC2909764.
32. Hofmann MC, Braydich-Stolle L, Dym M. Isolation of male germ-line stem cells; influence of GDNF. Dev Biol 279(1):114-24, 3/2005. PMCID: PMC2904978.
33. Hofmann MC, Braydich-Stolle L, Dettin L, Johnson E, Dym M. Immortalization of mouse germ line stem cells. Stem Cells 23(2):200-10, 2/2005. PMCID: PMC3151429.

Last updated: 7/24/2014