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Marites P. Melancon, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Full Member, The University of Texas Health Science Center at Houston, Houston, TX
Adjunct Faculty, College of Pharmacy and health Sciences, Texas Southern University, Houston, TX

Research Interests

The main goal of my research is to apply the “seek and treat” strategy in the development of targeted imaging/therapeutic agents that will eventually be translated to the clinic to improve the management of cancer through early tumor detection and individualized therapy. My focus is on the development of novel contrast and/or therapeutic agents that has the ability noninvasively monitor and treat cellular processes at the molecular level that leads to new ways of diagnosing and characterizing disease, developing effective therapeutics, and monitoring response to these treatments. Currently, I am working on the synthesis, characterization and in vivo evaluation of multimodality and multifunctional MR-active nanoparticles for MRI-guided laser-induced thermal therapy targeted to head and neck cancer.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 1471
Houston, TX 77030
Room Number: FCT14.6002
Phone: 713-794-5387
Fax: 713-792-4098
Email: mmelancon@mdanderson.org

Education & Training

Degree-Granting Education

2007 The University of Texas Graduate School of Biomedical Sciences, Houston, TX, PHD, Biomedical Science Major in Biochemistry and Cancer Biology
2000 Ateneo de Manila University, Manila, Philippines, MS, Chemistry
1994 University of San Carlos, Cebu, Philippines, BS, Cum Laude, Chemistry

Experience/Service

Academic Appointments

Assistant Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 8/2012-9/2013
Instructor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2011-7/2012

Honors and Awards

2010 Career Development Award, SPORE Head and Neck, The University of Texas MD Anderson Cancer Center
2010 Trainee Excellence Award, The University of Texas MD Anderson Cancer Center
2010 Travel Award, 2010 World Molecular Imaging Congress, Kyoto, Japan
2009-2012 Odyssey Fellowship, University of Texas MD Anderson Cancer Center
2009 Travel Award, 2009 World Molecular Imaging Congress, Montreal, Canada
2008 Travel Award, 2008 World Molecular Imaging Congress, Nice, France
2000 Dean’s Award for Best Graduate Research, Ateneo de Manila University, Philippines
1997-1999 Department of Science and Technology- Philippine Council for Advanced Science and Technology Research and Development (DOST-PCASTRD) Scholarship, Philippines
1994 Cum Laude, University of San Carlos, Cebu Philippines

Selected Publications

Peer-Reviewed Original Research Articles

1. Melancon MP, Zhou M, Zhang R, Xiong C, Huang Q, Allen P, Wallace M, Myers J, Ellington A, Stafford RJ, Li C. Comparison of Selective Uptake and Imaging of Aptamer- and Antibody-Conjugated Hollow Nanoshells Targeted to Epidermal Growth Factor Receptors Overexpressed in Head and Neck Cancer. ACS Nano. In Press.
2. Tam AL, Melancon MP, Ensor J, Liu Y, Dixon K, McWatters A, Gupta S. Rabbit Hepatic Arterial Anatomy Variations: Implications on Experimental Design. Acta Radiol. In Press.
3. Singhana B, Slattery P, Chen A, Wallace MJ, Melancon MP. Light-Activatable Gold Nanoshells for Drug Delivery Applications. AAPS PharmSciTech. e-Pub 2/2014. PMID: 24550102.
4. Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace MJ, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with Doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Control Release 172(1):152-158, 11/2013. NIHMSID: NIHMS524047.
5. Melancon MP, Stafford RJ, Li C. Challenges to effective cancer nanotheranostics. J Control Release 164(2):177-82, 12/2012. e-Pub 8/2012. PMCID: PMC3504179.
6. You J, Zhang R, Xiong C, Zhong M, Melancon MP, Gupta S, Nick AM, Sood AK, Li C. Effective photothermal chemotherapyusing doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors. Cancer Res 72(18):4777-4786, 9/2012. e-Pub 8/2012. PMCID: PMC3445780.
7. Zhang G, Zhang R, Melancon MP, Wong K, You J, Huang Q, Bankson J, Liang D, Li C. The degradation and clearance of Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials 33(21):5376-83, 7/2012. e-Pub 4/2012. PMCID: PMC3356511.
8. Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery. J Control Release 156(2):265-72, 12/2011. e-Pub 7/2011. PMCID: PMC3203335.
9. Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Song S, Zhang R, Flores LG, Gelovani JG, Wang LV, Ku G, Stafford RJ, Li C. Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res 71(19):6116-21, 10/2011. e-Pub 8/2011. PMCID: PMC3185126.
10. Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 10/2011. e-Pub 7/2011. PMCID: PMC3195359.
11. Melancon MP, Li C. Multifunctional synthetic polymer-based therapeutic and diagnostic agents. Mol Imaging 10(1):28-42, 2/2011. PMCID: PMC3435883.
12. Melancon MP, Elliott A, Ji X, Shetty A, Yang Z, Tian M, Taylor B, Stafford RJ, Li C. Theranostics with multifunctional magnetic gold nanoshells: photothermal therapy and t2* magnetic resonance imaging. Invest Radiol 46(2):132-40, 2/2011. PMCID: PMC3435880.
13. Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 132(43):15351-8, 11/2010. PMCID: PMC2966020.
14. Melancon MP, Lu W, Huang Q, Thapa P, Zhou D, Ng C, Li C. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. Biomaterials 31(25):6567-73, 9/2010. PMCID: PMC2900486.
15. Melancon MP, Lu W, Li C. Gold-Based Magneto/Optical Nanostructures: Challenges for In Vivo Applications in Cancer Diagnostics and Therapy. Mater Res Bull 34(6):415-421, 6/2009. PMCID: PMC2891272.
16. Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Stafford J, Olson T, Zhang JZ, Li C. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 7(6):1730-9, 6/2008. PMCID: PMC2727060.
17. Melancon MP, Wang Y, Wen X, Bankson JA, Stephens LC, Jasser S, Gelovani JG, Myers JN, Li C. Development of a macromolecular dual-modality MR-optical imaging for sentinel lymph node mapping. Invest Radiol 42(8):569-78, 8/2007. PMCID: PMC2746745.
18. Melancon MP, Wang W, Wang Y, Shao R, Ji X, Gelovani JG, Li C. A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier. Pharm Res 24(6):1217-24, 6/2007. e-Pub 3/2007. PMCID: PMC2746742.
19. Wang W, Wu Q, Pasuelo MJ, McMurray JS, Li C. Probing for integrin alpha v beta3 binding of RGD peptides using fluorescence polarization. Bioconjug Chem 16(3):729-34, May-Jun, 5/2005. PMID: 15898744.
20. Tansey W, Ke S, Cao XY, Pasuelo MJ, Wallace S, Li C. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier. J Control Release 94(1):39-51, 1/2004. PMID: 14684270.
21. Pasuelo MJ , Dayrit FM. Development if quality assurance methods for medicinal plants using gas chromatography analysis. Kimika 17:5-11, 2001.

Invited Articles

1. Melancon MP, Zhou M, Li C. Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles. Acc Chem Res 44(10):947-956, 10/18/2011. e-Pub 8/17/2011. PMCID: PMC3196765.
2. Wen X, Cao X, Pasuelo MJ, Wendt R, Li C. Polymeric radiotracers in nuclear imaging. Curr Drug Deliv 1(4):377-84, 10/2004. PMID: 16305399.

Abstracts

1. Tam A, Melancon MP, Ensor J, Abdelsalam M, Appleton T, Dixon K, Miller J, McWatters A, Li C, Gupta S. Nanoparticle distribution after treatment of rabbit VX2 hepatic tumor with nanoparticle embolization and irreversible electroporation (IRE) or radiofrequency ablation (RFA). Radiological Socitey of North America (RSNA) Annual Meeting 2013, 11/2013.
2. Bouchard R, MacLallen C, Mitcham T, Ege O, Lee H, Stafford RJ, Melancon MP. Nanoparticle distribution after treatment of rabbit VX2 hepatic tumor with nanoparticle embolization and irreversible electroporation (IRE) or radiofrequency ablation (RFA). 2013 IEEE International Ultrasonics Symposium, 7/2013.
3. Zhou M, Song S, Melancon MP, Huang Q, Wen X, Gupta S, Li C. Dual functional [64Cu]CuS nanoparticles for combined phothothermal ablation and radiotherapy. Society of Nuclear Medicine and Molecular Imaging 2013 Annual Meeting, 6/2013.
4. Zhou M, Melancon MP, Zhao J, Huang Q, Wen X, Li C. Targeted CuS nanoparticles and near-infrared laser irradiation for phothothermal ablation therapy of KB cervical tumor xenograft. Society of Nuclear Medicine and Molecular Imaging 2013 Annual Meeting, 6/2013.
5. Zhou M, Ku G, Melancon MP, Huang Q, Wen X, Li C. Theranostic CuS nanoparticles for photoacoustic imaging and photomechanical therapy. Society of Nuclear Medicine and Molecular Imaging 2013 Annual Meeting, 6/2013.
6. Zhao J, Vykoukal J, Abdelsalam ME, Recio-Boiles A, Javadi S, Bankson J, Wallace MJ, Avritscher R, Melancon MP. Adipose-derived stem cells labeled with SPIO-coated hollow gold nanoshells as theranostic approach for liver injury. JVIR (Supplement) 24(4):S89 - S90 (#189), 4/2013.
7. Zhao J, Tam AL, Melancon MP, McWatters A, Gupta S, Li C. Electroporation Induced Delivery of siRNA-loaded Copper Sulfide Nanoparticles. JVIR (Supplement) 24(4):S22-S23 (#32), 4/2013.
8. Lee H, Liu Y, Zhao J, Zhou M, Bouchard R, Wallace MJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. JVIR (Supplement) 24(4):S91 (#192), 4/2013.
9. Melancon MP, Zerr JS, Stafford RJ, Zhou M, You J, Li C, Gupta S. Near-infrared laser-induced temperature changes mediated by systemically administered hollow gold nanoshells and intratumoral laser fiber. 2012 SIR Annual Scientific Meeting, 3/2012.
10. Melancon MP, Vykoukal J, Abdelsalam M, Zhao J, Hazle JD, Wallace MJ, Li C, Bankson J, Stafford RJ, Avritscher R. MR imaging for SPIO-labeled adipose-derived stem cells as a theranostic approach to management of liver injury. ISMRM Scientific Workshop, 1/2012.
11. Melancon MP. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. 2010 Symposia for Cancer Research, 10/2010.
12. Melancon MP. Targeted nanoshells for MRI-guided photothermal ablation. SPORE Head and Neck Investigators Meeting, 10/2010.
13. Zhou M, Zhang R, Huang M, Lu W, Melancon MP, Song S, Li C. A new chelator-free multifuctional [64Cu]-CuS nanoparticle platform for simultaneous µPET/CT imaging and photothermal ablation therapy. 2010 World Molecular Imaging Congress, 9/2010.
14. Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Stafford RJ, Li C. Brain Tumor theranostics: photoacoustic tomography-guided thermal ablation mediated with targeted hollow gold nanospheres (HAuNS). 2010 World Molecular Imaging Congress, 9/2010.
15. Melancon MP, Lu W, Elliott A, Taylor B, Huang Q, Hazle J, Ng C, Li C, Stafford RJ. MRI-guided thermal ablation using multimodality, multifunctional SPIO@Au nanoshell targeted to epidermal growth factor receptors. 2010 World Molecular Imaging Congress, 9/2010.
16. Zhang G, Melancon MP, Zhang R, Wen X, Li C. Synthesis and evaluation of biodegradable and nonionic polymeric MRI agent: poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd. 2010 World Molecular Imaging Congress, 9/2010.
17. Melancon MP, Lu W, Huang Q, Thapa P, Zhou D, Ng C, Li C. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. 2010 World Molecular Imaging Congress, 9/2010.
18. Melancon MP, Lu W, Huang Q, Thapa P, Wen X, Xiong C, Zhou D, Ng C, Li C. Mechanism for the uptake of long circulating biodegradable polymeric MR contrast agent in tumor necrotic area. 2009 World Molecular Imaging Congress, 9/2009.
19. Melancon MP, Huang Q, May S, Brown B, Sano D, Myers J, Ng C, Li C. Theranostics of head & neck cancer using targeted hollow gold nanoshells. 2009 World Molecular Imaging Congress, 9/2009.
20. Shetty A, Melancon MP, Elliott AM, Huang Q, Wen X, Li C, Hazle J, Stafford RJ. MRTI perfusion changes following EGFR targeted hollow gold-nanoshell mediated heating of tumors. 17th ISMRM, 4/2009.
21. Melancon MP, Zhi Y, Wen X, Lu W, Tong W, Gelovani Y, Li C. Extravasation of dual magneto-optical polymeric contrast agent into the lymph is enhanced by treatment with poly(glutamate)-taxol conjugate. 2008 World Molecular Imaging Congress, 9/2008.
22. Melancon MP, Shetty A, Huang Q, Williams R, Wen X, Elliott A,Gelovani J, Stafford RJ, Li C. Hollow gold nanospheres (HGNSs)-mediated hyperthermia causes increased vascular perfusion in tumors for enhanced delivery of polymeric drug. 2008 World Molecular Imaging Congress, 9/2008.
23. Melancon MP, Lu W, Zhi Y, Zhang R, Elliott A, Shetty A, Stafford RJ, Olson T, Gelovani J, Zhang J, Li C. In vitro and in vivo targeting of hollow gold nanospheres (HGNSs) directed at EGF receptors. 2008 World Molecular Imaging Congress, 9/2008.
24. Melancon MP, Elliott A, Shetty A, Taylor B, Ji X, Huang Q, Gelovani J, Stafford RJ, Li C. Theragnostics with magnetic gold nanoshells: photothermal therapy and T2* magnetic resonance imaging. 2008 World Molecular Imaging Congress, 9/2008.
25. Elliott AM, Shetty A, Melancon MP, Ji X, Taylor B, Hazle J, Li C, Stafford J. MRTI evaluation of SPIO core gold coated nanoshells for thermal therapy and as T2* contrast agent. 16th ISMRM, 5/2008.

Book Chapters

1. Singhana B, Slattery P, Melancon MP. Targeted Gold Nanoshells. In: Applications of Nanoscience in Photomedicine. Woodhead Publishing Limited. In Press.
2. Lu W, Melancon MP, Li C. Theranostic Applications of Gold Core-Shell Structured Nanoparticles. In: Nanoplatform-based Molecular Imaging. John Wiley & Sons Publishing: Hoboken, NJ, 683-708, 2011.
3. Melancon MP, Wen X, Zhang G, Li C. Multi-functional multi-modality cancer imaging with synthetic polymers. In: Nanoimaging. Ed(s) Torchillin, V. and Amiji, M. Pan Stanford Publishing Pte Ltd: Singapore, 2010.
4. Melancon MP, Li C. Core-shell magnetic nanomaterials for medical diagnosis and therapy. In: Magnetic Nanomaterials. Ed(s) C. Kumar. Wiley-VCH: Weinheim, Germany, 259-290, 2009.

Last updated: 7/2/2014