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Mark T. Bedford, Ph.D.

Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science

About Dr. Bedford

Dr. Bedford’s laboratory focuses on two research topics: 1) elucidating the biological role of arginine methylation – an abundant modification that has been implicated in signal transduction, transcriptional control and DNA repair, and 2) developing a protein domain microarray platform to interrogate the role of posttranslational modifications in driving protein-protein interactions in signal transduction. They have generated targeted disruptions and gain-of-function mouse models for these arginine methyltransferase enzymes, with a primary focus on CARM1. Using their protein-domain microarray platform, they have identified and characterized novel protein interactions; they have used these arrays to “read” the histone code. They have identified a number of novel proteins that interact with lysine and arginine methylated motifs, as well as with small molecules that can compete with these interactions. Recently, the Bedford lab expanded their array platform to include all the human phospho-reader domains, acetyl-reader domains, and most of the human PDZ domains and ubiquitin-binding domains.

Primary Appointment

Professor, Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX

Co-Director, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX

Associate Administrative Director, Research and Facilities, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

The Bedford Lab studies the intersection between epigenetics and cancer with a specific focus on one class of epigenetic mark - arginine methylation. To better understand the biological roles of arginine methylation, their research group uses a number of different biological approaches to interrogate PRMT function. These include mouse gain- and loss-of-function PRMT models, protein microarrays screens for methyl-binding proteins, biochemical screens for PRMT substrates, and screens for chemical inhibitors of PRMT family members. They have generated targeted disruptions of a number of arginine methyltransferase genes in mice in the hopes of unmasking cellular and tissue-specific roles for this post-translational modification. In-hand they currently have CARM1, PRMT3 and PRMT6 null mice. They are performing transcriptome analysis (RNA-seq) and ChIP-seq on these null mice to identify the repertoire of genes that they regulate. The Bedford group is also performing double knockouts to investigate redundancy between the different PRMTs. They are also generating gain-of-function transgenic mouse models to determine the effects of PRMT overexpression in vivo. These are transgenic mice that can be activated by crossing to a tissue-specific cre line. The Cre expression removes a lox/STOP/los cassette and activates expression of the PRMT. They have already generated PRMT6 gain-of-function mice using this approach. They are currently producing CARM1, PRMT1, PRMT5 and TDRD3 transgenic mice using the same approach.

Education & Training

Degree-Granting Education

1996	Weizmann Institute of Science, IL, Ph.D. in Developmental Biology
1989	University of Stellenbosch, ZA, M.S. in Medical Biochemistry
1986	University of Stellenbosch, ZA, BS in Honors in Biochemistry
1985	University of Stellenbosch, ZA, BS

Postgraduate Training

1996-2000

Postdoctoral Fellowship, Harvard Medical School, Boston, Massachusetts

Experience & Service

Academic Appointments

Professor, University of Pretoria, Pretoria, 2020 - 2023

Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine (Adjunct Appointment), Houston, TX, 2014 - 2020

Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX, 2006 - 2011

Assistant Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park, Smithville, TX, 2000 - 2006

Post-Doctoral Fellowship, Harvard Medical School, Boston, MA, 1996 - 2000

Administrative Appointments/Responsibilities

Associate Administrative Director, Research and Facilities, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2021

Director of Transgenic Mouse Facility, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2010 - 2013

Other Appointments/Responsibilities

Thomas Stull Matney Endowed Professorship in Cancer Genetics, The University of Texas Health Science Center - GSBS, Houston, TX, 2013 - 2018

Institutional Committee Activities

Member, Faculty Senate, 2018 - 2020

Chair of the RFA Subcommittee, Faculty Promotion & Tenure Committee, 2016 - 2019

Member, Graduate School of Biomedical Sciences (GSBS) Steering Committee Subcommittee, 2016 - 2019

Member, Faculty Promotion & Tenure Committee, 2015 - 2018

Chair, Graduate School of Biomedical Sciences (GSBS) Candidacy Exam Subcommittee, 2015 - 2016

Member, Graduate School of Biomedical Sciences (GSBS) Admissions Subcommittee, 2015 - 2016

Member, Technology Task Force Committee, 2014 - 2020

Chair, Faculty Search Committee (Molecular Carcinogenesis), 2014 - 2014

Member, Faculty Search Committee (Search for Chair of Biochemistry & Molecular Biology), 2013 - 2013

Reviewer, IRG Study Section Review Committee for Clinical Translational and Population-Based Research Projects, UTMDACC, 2012 - 2016

Co-organizer, CCE Retreat, 2012 - Present

Member, Faculty Search Committee (Molecular Carcinogenesis), 2012 - 2012

Member, 2012 Alfred Knudson Award Committee (GSBS), 2012 - 2013

Member, Graduate Education Committee, 2011 - 2014

Member, Study Section Review Committee for the Sister Institution Network Funding (SINF) Program, 2011 - 2016

Member, MDACC Space Committee, 2011 - 2015

Member, MDACC Graduate Education Committee, 2011 - 2014

Member, Faculty Search Committee (Molecular Carcinogenesis), 2011 - Present

Member, Graduate School of Biomedical Sciences (GSBS) Academic Standards Committee, 2010 - 2014

Member, Molecular Carcinogenesis Program, Candidacy Exam (sub-committee), 2010 - Present

Chair, Faculty Search Committee (Molecular Carcinogenesis), 2010 - Present

Chair, Molecular Carcinogenesis Program, Academic Affairs (sub-committee), 2010 - Present

Member, Faculty Search Committee (Biochemistry & Molecular Biology), 2008 - 2009

Member, Center for Cancer Epigenetics (CCE) Executive Committee, 2008 - Present

Co-Chair, Faculty Search Committee (Molecular Carcinogenesis), 2008 - 2009

Chair, Graduate School of Biomedical Sciences (GSBS) Admissions Committee, 2008 - 2009

Member, Graduate School of Biomedical Sciences (GSBS) Executive Committee, 2008 - 2010

Chair, Hogg Seminar Series, 2007 - Present

Member, Odyssey Postdoctoral Review Committee, 2007 - 2010

Chair, The Winter Retreat Committee, 2006 - 2006

Member, Departmental Tenure and Promotions Committee, 2006 - Present

Member, Graduate School of Biomedical Sciences (GSBS) Admissions Committee, 2006 - 2008

Member, Molecular Carcinogenesis Program, Admissions (sub-committee), 2005 - Present

Member, Library Committee, 2003 - 2010

Member, Molecular Carcinogenesis Program Steering Committee, GSBS, UTHSC, 2003 - 2013

Member, Postdoctoral Training Grant Committee, 2001 - 2013

Member, Faculty Search Committee (Carcinogenesis), 2001 - 2001

Member, GSBS Faculty, UT Health Science Center, 2000 - Present

Honors & Awards

2015	Kenneth D. Muller Professorship in Tumor Genetics
2013	Thomas Stull Matney, PhD, Endowed Professorship in Cancer Genetics
2006	Faculty Scholar Award, The University of Texas M.D. Anderson Cancer Center
2002	Damon Runyon - Walter Winchell Scholar Award
1997	Damon Runyon - Walter Winchell Postdoctoral Fellow
1996	Howard Hughes Postdoctoral fellow
1992	EMBO fellowship to visit the Institut de Chimie Biologique Strasbourg (2 weeks)
1991	FEBS Youth Travel Fund for course attendance, Prague
1989	Graduated MSc cum laude, University of Stellenbosch
1988	Studentship to the Weizmann Institute of Science for Three months
1986	Graduated BSc (Hons) cum laude, University of Stellenbosch

Professional Memberships

American Association for the Advancement of Sciences (AAAS)

2000 - Present

Federation of American Societies for Experimental Biology

2000 - Present

Graduate School of Biomedical Science, UTHSC

2000 - Present

Selected Publications

Peer-Reviewed Articles

Gunamalai, L, Singh, P, Berg, B, Shi, L, Sanchez, E, Smith, A, Breton, G, Bedford, MT, Balciunas, D, Kapoor, A. Functional characterization of QT interval associated SCN5A enhancer variants identify combined additive effects. Human Genetics and Genomics Advances 6(1), 2025. e-Pub 2025. PMID: 39354714.
Min, KW, Choi, KM, Mun, H, Ko, S, Lee, JW, Sagum, C, Bedford, MT, Kim, YK, Delaney, JR, Cho, JH, Dawson, TM, Dawson, VL, Twal, W, Kim, DC, Panganiban, CH, Lang, H, Zhou, X, Shin, S, Hu, J, Heise, T, Kwon, SH, Kim, D, Kim, YH, Kang, SU, Kim, K, Lewis, S, Eroglu, A, Ryu, S, Kim, D, Chang, JH, Jung, J, Yoon, JH. Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release. Journal of cell science 137(21), 2024. e-Pub 2024. PMID: 39308343.
He, Q, Zhang, Y, Li, W, Chen, S, Xiong, J, Zhao, R, Yuan, K, Hu, Q, Liu, S, Gao, G, Bedford, MT, Tang, DG, Xu, B, Zou, C, Zhang, D. Inhibition of PRMT5 moderately suppresses prostate cancer growth in vivo but enhances its response to immunotherapy. Cancer Letters 602, 2024. e-Pub 2024. PMID: 39218291.
Chen, S, Hou, J, Jaffery, R, Guerrero, AM, Fu, R, Shi, L, Zheng, N, Bohat, R, Egan, NA, Yu, C, Sharif, S, Lu, Y, He, W, Wang, S, Gjuka, D, Stone, E, Shah, P, Rodon Ahnert, J, Chen, T, Liu, X, Bedford, MT, Xu, H, Peng, W. MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors. Journal for immunotherapy of cancer 12(9), 2024. e-Pub 2024. PMID: 39313308.
Jones, CM, Rohwedder, A, Suen, KM, Mohajerani, SZ, Calabrese, AN, Knipp, S, Bedford, MT, Ladbury, JD. Affinity purification mass spectrometry characterisation of the interactome of receptor tyrosine kinase proline-rich motifs in cancer. Heliyon 10(15), 2024. e-Pub 2024. PMID: 39165974.
Srivastava, Y, Donta, MS, Mireles, LL, Paulucci-Holthauzen, A, Shi, L, Bedford, MT, Waxham, MN, McCrea, PD. Exploring the PDZ, DUF, and LIM Domains of Pdlim5 in Dendrite Branching. International journal of molecular sciences 25(15), 2024. e-Pub 2024. PMID: 39125895.
Wang, Y, Zhou, J, He, W, Fu, R, Shi, L, Dang, NK, Liu, B, Xu, H, Cheng, X, Bedford, MT. SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Cell Reports 43(7), 2024. e-Pub 2024. PMID: 38985674.
Mun, H, Lee, S, Choi, S, Jeong, JH, Ko, S, Chun, YL, Deaton, B, Yeager, CT, Boyette, A, Palmera, J, Newman, L, Zhou, P, Shin, S, Kim, DC, Sagum, C, Bedford, MT, Kim, YK, Kwon, J, Jung, J, Chang, JH, Yoon, JH. Targeting of CYP2E1 by miRNAs in alcohol-induced intestine injury. Molecules and cells 47(7), 2024. e-Pub 2024. PMID: 38901530.
Yaron-Barir, TM, Joughin, BA, Huntsman, E, Kerelsky, A, Cizin, DM, Cohen, BM, Regev, A, Song, J, Vasan, N, Lin, TY, Orozco, JM, Schoenherr, C, Sagum, C, Bedford, MT, Wynn, RM, Tso, SC, Chuang, DT, Li, L, Li, SS, Creixell, P, Krismer, K, Takegami, M, Lee, H, Zhang, B, Lu, J, Cossentino, I, Landry, SD, Uduman, M, Blenis, J, Elemento, O, Frame, MC, Hornbeck, PV, Cantley, LC, Turk, BE, Yaffe, MB, Johnson, JL. The intrinsic substrate specificity of the human tyrosine kinome. Nature 629(8014):1174-1181, 2024. e-Pub 2024. PMID: 38720073.
Tiniakou, I, Hsu, PF, Lopez-Zepeda, LS, Garipler, G, Esteva, E, Adams, NM, Jang, G, Soni, C, Lau, CM, Liu, F, Khodadadi-Jamayran, A, Rodrick, TC, Jones, DR, Tsirigos, A, Ohler, U, Bedford, MT, Nimer, SD, Kaartinen, VM, Mazzoni, EO, Reizis, B. Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation. Science Immunology 9(94), 2024. e-Pub 2024. PMID: 38608038.
Zhao, F, Deng, Y, Yang, F, Yan, Y, Feng, F, Peng, B, Gao, J, Bedford, MT, Li, H. Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in Transcriptional Attenuation. Journal of Molecular Biology 436(7), 2024. e-Pub 2024. PMID: 37977297.
Li, Y, Dobrolecki, LE, Sallas, C, Zhang, X, Kerr, TD, Bisht, D, Wang, Y, Awasthi, S, Kaundal, B, Wu, S, Peng, W, Mendillo, ML, Lu, Y, Jeter, CR, Peng, G, Liu, J, Westin, SN, Sood, AK, Lewis, MT, Das, J, Yi, S, Bedford, MT, McGrail, DJ, Sahni, N. PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition. Cell Reports Medicine 4(12), 2023. e-Pub 2023. PMID: 38118413.
Santos M, Hwang J, Bedford MT. CARM1 arginine methyltransferase as a therapeutic target for cancer. Journal of Biological Chemistry 299(9), 2023. e-Pub 2023. PMID: 37536629.
Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep 42(4):112316, 2023. e-Pub 2023. PMID: 36995937.
Wang Y, Bedford MT. Effectors and effects of arginine methylation. Biochem Soc Trans 51(2):725-734, 2023. e-Pub 2023. PMID: 37013969.
Horton JR, Zhou J, Chen Q, Zhang X, Bedford MT, Cheng X. A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J Biol Chem 299(2):102862, 2023. e-Pub 2023. PMID: 36596360.
Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT. The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. Nat Commun 14(1):363, 2023. e-Pub 2023. PMID: 36690626.
Wright, T, Wang, Y, Stratton, SA, Sebastian, MM, Liu, B, Johnson, DG, Bedford, MT. Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma. Biochemical Journal 148(22):1805-1816, 2023. e-Pub 2023. PMID: 37905668.
Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J. A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun 13(1):5453, 2022. e-Pub 2022. PMID: 36114190.
Iannelli G, Milite C, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Cavarelli J, Castellano S, Sbardella G. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem 65(17):11574-11606, 2022. e-Pub 2022. PMID: 35482954.
Admoni-Elisha L, Elbaz T, Chopra A, Shapira G, Bedford MT, Fry CJ, Shomron N, Biggar K, Feldman M, Levy D. TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma. Nucleic Acids Res 50(12):6903-6918, 2022. e-Pub 2022. PMID: 35694846.
Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1function with a positive allosteric modulator. Cell Chem Biol S2451-9456(21):00437-2, 2022. e-Pub 2022. PMID: 34715055.
Fedoriw A, Shi L, O'Brien S, Smitheman KN, Wang Y, Hou J, Sherk C, Rajapurkar S, Laraio J, Williams LJ, Xu C, Han G, Feng Q, Bedford MT, Wang L, Barbash O, Kruger RG, Hwu P, Mohammad HP, Peng W. Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses. Cancer Immunol Res 10(4):420-436, 2022. e-Pub 2022. PMID: 35181787.
Wang Y, Person MD, Bedford MT. Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens. Methods 200:80-86, 2022. e-Pub 2022. PMID: 34107353.
Van HT, Harkins PR, Patel A, Jain AK, Lu Y, Bedford MT, Santos MA. Methyl-lysine readers PHF20 and PHF20L1 define two distinct gene expression-regulating NSL complexes. J Biol Chem 298(3):101588, 2022. e-Pub 2022. PMID: 35033534.
Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R. Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep 37(13):110176, 2021. e-Pub 2021. PMID: 34965416.
Yu, D, Horton, JR, Yang, J, Hajian, T, Vedadi, M, Sagum, C, Bedford, MT, Blumenthal, RM, Zhang, X, Cheng, X. Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic acids research 49(20):11629-11642, 2021. e-Pub 2021. PMID: 34086966.
Jianji Chen FY, Liu B, Gao G, Sebastian M, Jeter C, Shen J, Person MD, Bedford MT. SPINDOC binds PARP1 to facilitate PARylation. Nat Commun 12(1):6362, 2021. e-Pub 2021. PMID: 34737271.
Maron, MI, Lehman, SM, Gayatri, S, DeAngelo, JD, Hegde, S, Lorton, BM, Sun, Y, Bai, DL, Sidoli, S, Gupta, V, Marunde, MR, Bone, JR, Sun, ZW, Bedford, MT, Shabanowitz, J, Chen, H, Hunt, DF, Shechter, D. Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. iScience 24(9), 2021. e-Pub 2021. PMID: 34505004.
Chen J, Horton J, Sagum C, Zhou J, Cheng X, Bedford MT. Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem J 478(10):1943-58, 2021. e-Pub 2021. PMID: 33969871.
Liang, J, Ruthel, G, Sagum, C, Bedford, MT, Sidhu, SS, Sudol, M, Jaladanki, CK, Fan, H, Freedman, BD, Harty, RN. Angiomotin counteracts the negative regulatory effect of host WWOX on viral PPxY-Mediated Egress. Journal of Virology 95(8), 2021. e-Pub 2021. PMID: 33536174.
Genois, MM, Gagné, JP, Yasuhara, T, Jackson, J, Saxena, S, Langelier, MF, Ahel, I, Bedford, MT, Pascal, JM, Vindigni, A, Poirier, GG, Zou, L. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Molecular cell 81(4):784-800.e8, 2021. e-Pub 2021. PMID: 33412112.
Shepley-Mctaggart, A, Schwoerer, MP, Sagum, C, Bedford, MT, Jaladanki, CK, Fan, H, Cassel, J, Harty, RN. Ubiquitin ligase smurf2 interacts with filovirus vp40 and promotes egress of vp40 vlps. Viruses 13(2), 2021. e-Pub 2021. PMID: 33673144.
Wright, T, Wang, Y, Bedford, MT. The role of the PRMT5-SND1 axis in hepatocellular carcinoma. Epigenomes 5(1), 2021. e-Pub 2021. PMID: 33768972.
Shepley-McTaggart A, Sagum CA, Oliva I, Rybakovsky E, DiGuilio K, Liang J, Bedford MT, Cassel J, Sudol M, Mullin JM, Harty RN. SARS-CoV-2 Envelope (E) Protein Interacts with PDZ-Domain-2 of Host Tight Junction Protein ZO1. PLoS One 16(6):e0251955, 2021. e-Pub 2021. PMID: 34106957.
Hwang, JW, Kim, SN, Myung, N, Song, D, Han, G, Bae, GU, Bedford, MT, Kim, YK. PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation. Communications Biology 3(1), 2020. e-Pub 2020. PMID: 32759981.
Vaughan, RM, Kupai, A, Foley, CA, Sagum, C, Tibben, BM, Eden, HE, Tiedemann, RL, Berryhill, CA, Patel, V, Shaw, KM, Krajewski, K, Strahl, BD, Bedford, MT, Frye, SV, Dickson, BM, Rothbart, SB. The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells. Epigenetics and Chromatin 13(1), 2020. e-Pub 2020. PMID: 33097091.
Tetenborg, S, Wang, HY, Nemitz, L, Depping, A, Espejo, A, Aseervatham, J, Bedford, MT, Janssen-Bienhold, U, O’Brien, J, Dedek, K. Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14–3–3 proteins in vitro. Scientific reports 10(1), 2020. e-Pub 2020. PMID: 33110101.
Veazey, KJ, Cheng, D, Lin, H, Villarreal, OD, Gao, G, Perez-Oquendo, M, Van, HT, Stratton, SA, Green, M, Xu, H, Lu, Y, Bedford, MT, Albuquerque Almeida Santos, M. CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia 34(12):3269-3285, 2020. e-Pub 2020. PMID: 32576962.
Chen J, Sagum C, Bedford MT. Protein domain microarrays as a platform to decipher signaling pathways and the histone code. Methods 184:4-12, 2020. e-Pub 2020. PMID: 31449908.
Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT. Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. J Biol Chem 295(50):17060-70, 2020. e-Pub 2020. PMID: 33008887.
Woodcock, CB, Horton, JR, Zhou, J, Bedford, MT, Blumenthal, RM, Zhang, X, Cheng, X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic acids research 48(18):10329-10341, 2020. e-Pub 2020. PMID: 32663306.
Baumert, R, Ji, H, Paulucci-Holthauzen, A, Wolfe, A, Sagum, C, Hodgson, L, Arikkath, J, Chen, X, Bedford, MT, Waxham, MN, McCrea, PD. Novel phospho-switch function of delta-catenin in dendrite development. Journal of Cell Biology 219(11), 2020. e-Pub 2020. PMID: 33007084.
Prasanth, KR, Hirano, M, Fagg, WS, McAnarney, ET, Shan, C, Xie, X, Hage, A, Pietzsch, CA, Bukreyev, A, Rajsbaum, R, Shi, PY, Bedford, MT, Bradrick, SS, Menachery, V, Garcia-Blanco, MA. Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses. Antiviral Research 182, 2020. e-Pub 2020. PMID: 32735900.
Shen, Y, Gao, G, Yu, X, Kim, H, Wang, L, Xie, L, Schwarz, M, Chen, X, Guccione, E, Liu, J, Bedford, MT, Jin, J. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. Journal of Medicinal Chemistry 63(17):9977-9989, 2020. e-Pub 2020. PMID: 32787082.
Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SAW, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan CC, Mancini MA. Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity. Nucleic Acids Res 48(4):1800-10, 2020. e-Pub 2020. PMID: 31930333.
Jain, K, Fraser, CS, Marunde, MR, Parker, MM, Sagum, C, Burg, JM, Hall, N, Popova, IK, Rodriguez, KL, Vaidya, A, Krajewski, K, Keogh, MC, Bedford, MT, Strahl, BD. Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions. Epigenetics and Chromatin 13(1), 2020. e-Pub 2020. PMID: 31980037.
Avasarala, S, Wu, PY, Khan, SQ, Yanlin, S, Van Scoyk, M, Bao, J, Di Lorenzo, A, David, O, Bedford, MT, Gupta, V, Winn, RA, Bikkavilli, RK. PRMT6 promotes lung tumor progression via the alternate activation of tumor-associated macrophages. Molecular Cancer Research 18(1):166-178, 2020. e-Pub 2020. PMID: 31619507.
Han, Z, Dash, S, Sagum, C, Ruthel, G, Jaladanki, CK, Berry, CT, Schwoerer, MP, Harty, NM, Freedman, BD, Bedford, MT, Fan, H, Sidhu, SS, Sudol, M, Shtanko, O, Harty, RN. Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40. PLoS pathogens 16(1), 2020. e-Pub 2020. PMID: 31905227.
Wu, X, Liu, S, Sagum, C, Chen, J, Singh, R, Chaturvedi, A, Horton, JR, Kashyap, TR, Fushman, D, Cheng, X, Bedford, MT, Wang, B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes & development 33(23-24):1702-1717, 2019. e-Pub 2019. PMID: 31699778.
Manickavinayaham, S, Velez-Cruz, R, Biswas, AK, Bedford, E, Klein, BJ, Kutateladze, TG, Liu, B, Bedford, MT, Johnson, DG. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nature communications 10(1), 2019. e-Pub 2019. PMID: 31666529.
He, W, Zhang, L, Villarreal, OD, Fu, R, Bedford, E, Dou, J, Patel, AY, Bedford, MT, Shi, X, Chen, T, Bartholomew, B, Xu, H. De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. Nature communications 10(1), 2019. e-Pub 2019. PMID: 31586052.
Lamb, KN, Bsteh, D, Dishman, SN, Moussa, HF, Fan, H, Stuckey, JI, Norris, JL, Cholensky, SH, Li, D, Wang, J, Sagum, C, Stanton, BZ, Bedford, MT, Pearce, KH, Kenakin, TP, Kireev, DB, Wang, GG, James, LI, Bell, O, Frye, SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chemical Biology 26(10):1365-1379.e22, 2019. e-Pub 2019. PMID: 31422906.
Stuckey, JI, Dickson, BM, Cheng, N, Liu, Y, Norris, JL, Cholensky, SH, Tempel, W, Qin, S, Huber, KG, Sagum, C, Black, K, Li, F, Huang, XP, Roth, BL, Baughman, BM, Senisterra, G, Pattenden, SG, Vedadi, M, Brown, PJ, Bedford, MT, Min, J, Arrowsmith, CH, James, LI, Frye, SV. Erratum. Nature Chemical Biology 15(8):846, 2019. e-Pub 2019. PMID: 30842648.
Gao, G, Zhang, L, Villarreal, OD, He, W, Su, D, Bedford, E, Moh, P, Shen, J, Shi, X, Bedford, MT, Xu, H. PRMT1 loss sensitizes cells to PRMT5 inhibition. Nucleic acids research 47(10):5038-5048, 2019. e-Pub 2019. PMID: 30916320.
Rajendran, P, Johnson, G, Li, L, Chen, YS, Dashwood, M, Nguyen, N, Ulusan, A, Ertem, F, Zhang, M, Li, J, Sun, D, Huang, Y, Wang, S, Leung, HE, Lieberman, D, Beaver, L, Ho, E, Bedford, MT, Chang, K, Vilar Sanchez, E, Dashwood, R. Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. Cancer Research 79(5):918-927, 2019. e-Pub 2019. PMID: 30643017.
Roth, L, Wakim, J, Wasserman, E, Shalev, M, Arman, E, Stein, M, Brumfeld, V, Sagum, C, Bedford, MT, Tuckermann, JP, Elson, A. Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo. Science signaling 12(563), 2019. e-Pub 2019. PMID: 30622194.
Bao, J, Lorenzo, AD, Lin, H, Lu, Y, Zhong, Y, Sebastian, MM, Muller, WJ, Yang, Y, Bedford, MT. Mouse models of overexpression reveal distinct oncogenic roles for different type I protein arginine methyltransferases. Cancer Research 79(1):21-32, 2019. e-Pub 2019. PMID: 30352814.
Hupalowska, A, Jedrusik, A, Zhu, M, Bedford, MT, Glover, DM, Zernicka-Goetz, M. CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell 175(7):1902-1916.e13, 2018. e-Pub 2018. PMID: 30550788.
Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Estévez R, Pan HL, Geha RS, Shi Q, Benavides F. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight 3(16), 2018. e-Pub 2018. PMID: 30135305.
Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T. Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9. J Biol Chem 293(33):12770-12780, 2018. e-Pub 2018. PMID: 29959229.
Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress. Diseases 6(3):64, 2018. e-Pub 2018.
Bao J, Rousseaux S, Shen J, Lin K, Lu Y, Bedford MT. The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis. Nucleic Acids Res 46(9):4327-4343, 2018. e-Pub 2018. PMID: 29659998.
Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV. Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1. Biochemistry 57(14):2140-2149, 2018. e-Pub 2018. PMID: 29558110.
Xi, Y, Shi, J, Li, W, Tanaka, K, Allton, K, Richardson, D, Li, J, Franco, HL, Nagari, A, Malladi, VS, Coletta, LD, Simper, M, Keyomarsi, K, Shen, J, Bedford, MT, Shi, X, Barton, M, Kraus, WL, Li, W, Dent, SR. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC genomics 19(1), 2018. e-Pub 2018. PMID: 29458327.
Kaushik, S, Liu, F, Veazey, KJ, Gao, G, Das, P, Neves, LF, Lin, H, Zhong, Y, Lu, Y, Giuliani, V, Bedford, MT, Nimer, SD, Albuquerque Almeida Santos, M. Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML. Leukemia 32(2):499-509, 2018. e-Pub 2018. PMID: 28663579.
Franco, HL, Nagari, A, Malladi, VS, Li, W, Xi, Y, Richardson, D, Allton, K, Tanaka, K, Li, J, Murakami, S, Keyomarsi, K, Bedford, MT, Shi, X, Li, W, Barton, M, Dent, SR, Kraus, WL. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome research 28(2):159-170, 2018. e-Pub 2018. PMID: 29273624.
Cheng, D, Vemulapalli, V, Lu, Y, Shen, J, Aoyagi, S, Fry, C, Yang, Y, Foulds, CE, Stossi, F, Trevino, LS, Mancini, MA, O'Malley, B, Walker, C, Boyer, TG, Bedford, MT. CARM1 methylates MED12 to regulate its RNA-binding ability. Life science alliance 1(5), 2018. e-Pub 2018. PMID: 30456381.
Bae, N, Gao, M, Li, X, Premkumar, T, Sbardella, G, Chen, J, Bedford, MT. A transcriptional coregulator, SPIN-DOC, attenuates the coactivator activity of Spindlin1. Journal of Biological Chemistry 292(51):20808-20817, 2017. e-Pub 2017. PMID: 29061846.
Veland, N, Hardikar, S, Zhong, Y, Gayatri, S, Dan, J, Strahl, BD, Rothbart, SB, Bedford, MT, Chen, T. The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Reports 21(12):3390-3397, 2017. e-Pub 2017. PMID: 29262320.
Carr, SM, Munro, S, Sagum, C, Fedorov, O, Bedford, MT, La Thangue, NB. Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein. Cell death and differentiation 24(12):2139-2149, 2017. e-Pub 2017. PMID: 28841214.
Han, Z, Sagum, C, Takizawa, F, Ruthel, G, Berry, CT, Kong, J, Oriol Sunyer, J, Freedman, BD, Bedford, MT, Sidhu, SS, Sudol, M, Harty, RN. Ubiquitin ligase WWP1 interacts with Ebola virus VP40 to regulate egress. Journal of Virology 91(20), 2017. e-Pub 2017. PMID: 28768865.
Gates, LA, Shi, J, Rohira, AD, Feng, Q, Zhu, B, Bedford, MT, Sagum, C, Jung, SY, Qin, J, Tsai, MJ, Tsai, SY, Li, W, Foulds, CE, O'Malley, B. Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation. Journal of Biological Chemistry 292(35):14456-14472, 2017. e-Pub 2017. PMID: 28717009.
Liang, J, Sagum, C, Bedford, MT, Sidhu, SS, Sudol, M, Han, Z, Harty, RN. Erratum. PLoS pathogens 13(7):e1006519, 2017. e-Pub 2017. PMID: 28723972.
Bae, N, Viviano, M, Su, X, Lv, J, Cheng, D, Sagum, C, Castellano, S, Bai, X, Johnson, C, Khalil, MI, Shen, J, Chen, K, Li, H, Sbardella, G, Bedford, MT. Developing Spindlin1 small-molecule inhibitors by using protein microarrays. Nature Chemical Biology 13(7):750-756, 2017. e-Pub 2017. PMID: 28504676.
Shanle, EK, Shinsky, SA, Bridgers, JB, Bae, N, Sagum, C, Krajewski, K, Rothbart, SB, Bedford, MT*, Strahl, BD*. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics and Chromatin 10(1), 2017. e-Pub 2017. PMID: 28293301.
Espejo, A, Gao, G, Black, K, Gayatri, S, Veland, N, Kim, J, Chen, T, Sudol, M, Walker, C, Bedford, MT. PRMT5 C-terminal phosphorylation modulates a 14-3-3/PDZ interaction switch. Journal of Biological Chemistry 292(6):2255-2265, 2017. e-Pub 2017. PMID: 28031468.
Liang, J, Sagum, C, Bedford, MT, Sidhu, SS, Sudol, M, Han, Z, Harty, RN. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS pathogens 13(1), 2017. e-Pub 2017. PMID: 28076420.
Gao, G, Dhar, S, Bedford, MT. PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1. Nucleic acids research 45(8):4359-4369, 2017. e-Pub 2017. PMID: 28115626.
Norrie, JL, Li, Q, Co, S, Huang, BL, Ding, D, Uy, JC, Ji, Z, Mackem, S, Bedford, MT, Galli, A, Ji, H, Vokes, SA. PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development (Cambridge) 143(24):4608-4619, 2016. e-Pub 2016. PMID: 27827819.
Estève, PO, Zhang, G, Ponnaluri, VK, Deepti, K, Chin, HG, Dai, N, Sagum, C, Black, K, Corrêa, IR, Bedford, MT, Cheng, X, Pradhan, S. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic acids research 44(4):1642-1656, 2016. e-Pub 2016. PMID: 26553800.
Tsai, WC, Gayatri, S, Reineke, LC, Sbardella, G, Bedford, MT, Lloyd, RE. Arginine demethylation of G3BP1 promotes stress granule assembly. Journal of Biological Chemistry 291(43):22671-22685, 2016. e-Pub 2016. PMID: 27601476.
Park, IY, Powell, RT, Tripathi, DN, Dere, R, Ho, TH, Blasius, TL, Chiang, YC, Davis, IJ, Fahey, CC, Hacker, KE, Verhey, KJ, Bedford, MT, Jonasch, E, Rathmell, WK, Walker, CL. Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell 166(4):950-962, 2016. e-Pub 2016. PMID: 27518565.
Gayatri, S, Cowles, MW, Vemulapalli, V, Cheng, D, Sun, ZW, Bedford, MT. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Scientific reports 6, 2016. e-Pub 2016. PMID: 27338245.
Hossain, MB, Shifat, R, Johnson, DG, Bedford, MT, Gabrusiewicz, KR, Cortes-Santiago, N, Luo, X, Lu, Z, Ezhilarasan, R, Sulman, EP, Jiang, H, Li, SS, Lang Jr, FF, Tyler, J, Hung, M, Fueyo-Margareto, J, Gomez-Manzano, C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Science advances 2:e1501290, 2016. e-Pub 2016. PMID: 27757426.
Zhang, X, Peng, D, Xi, Y, Yuan, C, Sagum, C, Klein, BJ, Tanaka, K, Wen, H, Kutateladze, TG, Li, W, Bedford, MT, Shi, X. G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nature communications 7, 2016. e-Pub 2016. PMID: 26960573.
Metzger, E, Willmann, D, McMillan, J, Forne, I, Metzger, P, Gerhardt, S, Petroll, K, Von Maessenhausen, A, Urban, S, Schott, AK, Espejo, A, Eberlin, A, Wohlwend, D, Schüle, KM, Schleicher, M, Perner, S, Bedford, MT, Jung, M, Dengjel, J, Flaig, R, Imhof, A, Einsle, O, Schüle, R. Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Nature Structural and Molecular Biology 23(2):132-139, 2016. e-Pub 2016. PMID: 26751641.
Stuckey, JI, Dickson, BM, Cheng, N, Liu, Y, Norris, JL, Cholensky, SH, Tempel, W, Qin, S, Huber, KG, Sagum, C, Black, K, Li, F, Huang, XP, Roth, BL, Baughman, BM, Senisterra, G, Pattenden, SG, Vedadi, M, Brown, PJ, Bedford, MT, Min, J, Arrowsmith, CH, James, LI, Frye, SV. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology 12(3):180-187, 2016. e-Pub 2016. PMID: 26807715.
Han, Z, Sagum, C, Bedford, MT, Sidhu, SS, Sudol, M, Harty, RN. ITCH E3 ubiquitin ligase interacts with Ebola virus VP40 to regulate budding. Journal of Virology 90(20):9163-9171, 2016. e-Pub 2016. PMID: 27489272.
Perez, C, Mecklenburg, L, Jaubert, J, Martinez-Santamaria, L, Iritani, BM, Espejo, A, Napoli, E, Song, G, Del Río, M, DiGiovanni, J, Giulivi, C, Bedford, MT, Dent, SR, Wood, R, Kusewitt, DF, Guenet, JL, Conti, CJ, Benavides, FJ. Increased susceptibility to skin carcinogenesis associated with a spontaneous mouse mutation in the palmitoyl transferase Zdhhc13 gene. Journal of Investigative Dermatology 135(12):3133-3143, 2015. e-Pub 2015. PMID: 26288350.
Sarker, RS, John-Schuster, G, Bohla, A, Mutze, K, Burgstaller, G, Bedford, MT, Nigshoff, MK, Eickelberg, O, Yildirim, AO. Coactivator-associated arginine methyltransferase-1 function in alveolar epithelial senescence and elastase-induced emphysema susceptibility. American journal of respiratory cell and molecular biology 53(6):769-781, 2015. e-Pub 2015. PMID: 25906418.
Hadjikyriacou, A, Yang, Y, Espejo, A, Bedford, MT, Clarke, S. Unique features of human protein arginine methyltransferase 9 (PRMT9) and its substrate RNA splicing factor SF3B2. Journal of Biological Chemistry 290(27):16723-16743, 2015. e-Pub 2015. PMID: 25979344.
Yang, Y, Hadjikyriacou, A, Xia, Z, Gayatri, S, Kim, D, Zurita-Lopez, C, Kelly, R, Guo, A, Li, W, Clarke, S, Bedford, MT. PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145. Nature communications 6, 2015. e-Pub 2015. PMID: 25737013.
Hu, SB, Xiang, JF, Li, X, Xu, Y, Xue, W, Huang, M, Wong, CC, Sagum, C, Bedford, MT, Yang, L, Cheng, D, Chen, LL. Protein arginine methyltransferase CARM1 attenuates the paraspecklemediated nuclear retention of mRNAs containing IRAlus. Genes and Development 29(6):630-645, 2015. e-Pub 2015. PMID: 25792598.
Kapoor, P, Bao, Y, Xiao, J, Espejo, A, Yang, L, Bedford, MT, Peng, G, Shen, X. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Molecular cell 58(5):863-869, 2014. e-Pub 2014. PMID: 25959398.
Carr, SM, Munro, S, Zalmas, LP, Fedorov, O, Johansson, C, Krojer, T, Sagum, C, Bedford, MT, Oppermann, U, La Thangue, NB. Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America 111(31):11341-11346, 2014. e-Pub 2014. PMID: 25049398.
Di Lorenzo, A, Yang, Y, Macaluso, M, Bedford, MT. A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator. Nucleic acids research 42(13):8297-8309, 2014. e-Pub 2014. PMID: 24939901.
Estève, PO, Terragni, J, Deepti, K, Chin, HG, Dai, N, Espejo, A, Corrêa, IR, Bedford, MT, Pradhan, S. Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. Journal of Biological Chemistry 289(12):8277-8287, 2014. e-Pub 2014. PMID: 24492612.
Yang, Y, McBride, K, Hensley, S, Lu, Y, Chedin, F, Bedford, MT. Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation. Molecular cell 53(3):484-497, 2014. e-Pub 2014. PMID: 24507716.
Mallaret, M, Synofzik, M, Lee, J, Sagum, C, Mahajnah, M, Sharkia, R, Drouot, N, Renaud, M, Klein, FA, Anheim, M, Tranchant, C, Mignot, C, Mandel, JL, Bedford, MT, Bauer, P, Salih, MA, Schüle, R, Schöls, L, Aldaz, CM, Koenig, M. The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain 137(2):411-419, 2014. e-Pub 2014. PMID: 24369382.
Guo, A, Gu, H, Zhou, J, Mulhern, D, Wang, Y, Lee, KA, Yang, V, Aguiar, M, Kornhauser, J, Jia, X, Ren, J, Beausoleil, SA, Silva, JC, Vemulapalli, V, Bedford, MT, Comb, MJ. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Molecular and Cellular Proteomics 13(1):372-387, 2014. e-Pub 2014. PMID: 24129315.
Levy-Apter, E, Finkelshtein, E, Vemulapalli, V, Li, SS, Bedford, MT, Elson, A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ∈ in osteoclasts. Journal of Biological Chemistry 289(52):36048-36058, 2014. e-Pub 2014. PMID: 25381250.
Feng, Y, Maity, R, Whitelegge, JP, Hadjikyriacou, A, Li, Z, Zurita-Lopez, C, Al-Hadid, Q, Clark, AT, Bedford, MT, Masson, JY, Clarke, S. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. Journal of Biological Chemistry 288(52):37010-37025, 2013. e-Pub 2013. PMID: 24247247.
Zheng, S, Moehlenbrink, J, Lu, YC, Zalmas, LP, Sagum, C, Carr, SM, McGouran, JF, Alexander, L, Fedorov, O, Munro, S, Kessler, B, Bedford, MT, Yu, Q, La Thangue, NB. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Molecular cell 52(1):37-51, 2013. e-Pub 2013. PMID: 24076217.
Zeng, H, Wu, J, Bedford, MT, Sbardella, G, Hoffmann, FM, Bi, K, Xu, W. A TR-FRET-Based Functional Assay for Screening Activators of CARM1. ChemBioChem 14(7):827-835, 2013. e-Pub 2013. PMID: 23585185.
James LI, Barsyte-Lovejoy D, Zhong N, Krichesvky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CC, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, Emili A, Greenblatt JF, Kireev DB, Jin J, Janzen WP, Brown PJ, Bedford MT, Arrowsmith CH, Frye SV. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 9(3):184-91, 2013. e-Pub 2013. PMID: 23292653.
Bedford MT*, Li, J, Zhao, Z, Carter, C, Ehrlich, LI, Richie, ER*. Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immul 190(2):597-604, 2013. PMID: 23248263.
Dhar S, Vemulapalli V, Patananan AN, Huang G, DiLorenzo A, Richard S, Comb MJ, Guo A, Clarke SG, Bedford MT. Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep 3:1311, 2013. e-Pub 2013. PMID: 23419748.
Castellano, S, Spannhoff, A, Milite, C, Dal Piaz, F, Cheng, D, Tosco, A, Viviano, M, Yamani, A, Cianciulli, A, Sala, M, Cura, V, Cavarelli, J, Novellino, E, Mai, A, Bedford, MT, Sbardella, G. Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. Journal of Medicinal Chemistry 55(22):9875-9890, 2012. e-Pub 2012. PMID: 23095008.
Rothbart, SB, Krajewski, K, Nady, N, Tempel, W, Xue, S, Badeaux, AI, Barsyte-Lovejoy, D, Martinez, JY, Bedford, MT, Fuchs, SM, Arrowsmith, CH, Strahl, BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature Structural and Molecular Biology 19(11):1155-1160, 2012. e-Pub 2012. PMID: 23022729.
Kawabe, YI, Wang, YX, McKinnell, IW, Bedford, MT, Rudnicki, M. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell 11(3):333-345, 2012. e-Pub 2012. PMID: 22863532.
Calnan, DR, Webb, AE, White, JL, Stowe, TR, Goswami, T, Shi, X, Espejo, A, Bedford, MT, Gozani, O, Gygi, SP, Brunet, A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging 4(7):462-479, 2012. e-Pub 2012. PMID: 22820736.
Liu, K, Guo, Y, Liu, H, Bian, C, Lam, R, Liu, Y, Mackenzie, F, Rojas, LA, Reinberg, D, Bedford, MT, Xu, RM, Min, J. Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PloS one 7(2), 2012. e-Pub 2012. PMID: 22363433.
Zhao, H, Ho, PC, Lo, Y, Espejo, A, Bedford, MT, Hung, MC, Wang, SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PloS one 7(1), 2012. e-Pub 2012. PMID: 22238610.
Badeaux AI, Yang Y, Cardenas K, Vemulapalli V, Chen K, Kusewitt D, Richie E, Li W, Bedford MT. Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem 287(1):429-37, 2012. e-Pub 2012. PMID: 22072714.
Bedford MT, Cui, G, Park, S, Badeaux, Al, Kim, D, Lee, J, Thompson, JR, Yan, F, Kaneko, S, Yuan, Z, Botuyan, MV, Cheng, JQ*, Mer,G*. PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Strruct Mol Biol 19(9)(916):24, 2012. PMID: 22864287.
Cheng, D, Valente, S, Castellano, S, Sbardella, G, Di Santo, R, Costi, R, Bedford, MT, Mai, A. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors. Journal of Medicinal Chemistry 54(13):4928-4932, 2011. e-Pub 2011. PMID: 21612300.
Guo, Q, Bedford, MT, Fast, W. Discovery of peptidylarginine deiminase-4 substrates by protein array. Molecular BioSystems 7(7):2286-2295, 2011. e-Pub 2011. PMID: 21584310.
Bissinger, EM, Heinke, R, Spannhoff, A, Eberlin, A, Metzger, E, Cura, V, Hassenboehler, P, Cavarelli, J, Schüle, R, Bedford, MT, Sippl, W, Jung, M. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorganic and Medicinal Chemistry 19(12):3717-3731, 2011. e-Pub 2011. PMID: 21440447.
Chang, Y, Horton, JR, Bedford, MT, Zhang, X, Cheng, X. Structural insights for MPP8 chromodomain interaction with histone h3 lysine 9. Journal of Molecular Biology 408(5):807-814, 2011. e-Pub 2011. PMID: 21419134.
Cha, B, Kim, W, Kim, YK, Hwang, BN, Park, SY, Yoon, JW, Park, WS, Cho, JW, Bedford, MT, Jho, EH. Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene 30(20):2379-2389, 2011. e-Pub 2011. PMID: 21242974.
Butler, JS, Zurita-Lopez, C, Clarke, S, Bedford, MT, Dent, SR. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. Journal of Biological Chemistry 286(14):12234-12244, 2011. e-Pub 2011. PMID: 21285357.
Hsu, J, Chen, C, Chou, C, Kuo, HP, Li, L, Lin, CY, Lee, HJ, Wang, Y, Liu, M, Liao, HW, Shi, B, Lai, CC, Bedford, MT, Tsai, CH, Hung, M. Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature cell biology 13(2):174-181, 2011. e-Pub 2011. PMID: 21258366.
Cheng, D, Bedford, MT. Xenoestrogens Regulate the Activity of Arginine Methyltransferases. ChemBioChem 12(2):323-329, 2011. e-Pub 2011. PMID: 21243720.
Lee, YH, Bedford, MT, Stallcup, MR. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes and Development 25(2):176-188, 2011. e-Pub 2011. PMID: 21245169.
Levy, D, Kuo, AJ, Chang, Y, Schaefer, U, Kitson, C, Cheung, P, Espejo, A, Zee, BM, Liu, CL, Tangsombatvisit, S, Tennen, RI, Kuo, AY, Tanjing, S, Cheung, R, Chua, KF, Utz, PJ, Shi, X, Prinjha, RK, Lee, K, Garcia, BA, Bedford, MT, Tarakhovsky, A, Cheng, X, Gozani, O. Lysine methylation of the NF-κ B subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κ B signaling. Nature Immunology 12(1):29-36, 2011. e-Pub 2011. PMID: 21131967.
Chang, Y, Sun, L, Kokura, K, Horton, JR, Fukuda, M, Espejo, A, Izumi, V, Koomen, JM, Bedford, MT, Zhang, X, Shinkai, Y, Fang, J, Cheng, X. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nature communications 2(1), 2011. e-Pub 2011. PMID: 22086334.
Woolard, J, Vousden, W, Moss, SJ, Krishnakumar, A, Gammons, MV, Nowak, DG, Dixon, N, Micklefield, J, Spannhoff, A, Bedford, MT, Gregory, MA, Martin, CJ, Leadlay, PF, Zhang, MQ, Harper, SJ, Bates, DO, Wilkinson, B. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science 2(2):273-278, 2011. e-Pub 2011. PMID: 22822423.
Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, Li J, Castellano S, Sbardella G, Issa JP, Bedford MT. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep 12(3):238-43, 2011. e-Pub 2011. PMID: 21331099.
Kokura, K, Sun, L, Bedford, MT, Fang, J. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO Journal 29(21):3673-3687, 2010. e-Pub 2010. PMID: 20871592.
Zhu, F, Dollé, ME, Berton, TR, Kuiper, RV, Capps, C, Espejo, A, McArthur, MJ, Bedford, MT, Van Steeg, H, De Vries, A, Johnson, DG. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Research 70(14):5851-5859, 2010. e-Pub 2010. PMID: 20587514.
Chang, Y, Ganesh, T, Horton, JR, Spannhoff, A, Liu, J, Sun, A, Zhang, X, Bedford, MT, Shinkai, Y, Snyder, JP, Cheng, X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. Journal of Molecular Biology 400(1):1-7, 2010. e-Pub 2010. PMID: 20434463.
O'Brien, KB, Jordà, MA, Yadav, N, Kocher, O, Di Ruscio, A, Ebralidze, A, Levantini, E, Sng, NJ, Bhasin, M, Caron, T, Kim, D, Steidl, U, Huang, G, Halmos, B, Rodig, SJ, Bedford, MT, Tenen, DG, Kobayashi, S. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development 137(13):2147-2156, 2010. e-Pub 2010. PMID: 20530543.
Short, JD, Dere, R, Houston, KD, Cai, S, Kim, J, Bergeron, JM, Shen, J, Liang, J, Bedford, MT, Mills, GB, Walker, CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Molecular Carcinogenesis 49(5):429-439, 2010. e-Pub 2010. PMID: 20146253.
Bredfeldt, TG, Greathouse, KL, Safe, S, Hung, M, Bedford, MT, Walker, CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Molecular Endocrinology 24(5):993-1006, 2010. e-Pub 2010. PMID: 20351197.
Castellano, S, Milite, C, Ragno, R, Simeoni, S, Mai, A, Limongelli, V, Novellino, E, Bauer, I, Brosch, G, Spannhoff, A, Cheng, D, Bedford, MT, Sbardella, G. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem 5(3):398-414, 2010. e-Pub 2010. PMID: 20091730.
Kim, D, Lee, J, Cheng, D, Li, J, Carter, C, Richie, ER, Bedford, MT. Enzymatic activity is required for the in Vivo functions of CARM1. Journal of Biological Chemistry 285(2):1147-1152, 2010. e-Pub 2010. PMID: 19897492.
Liu H, Galka M, Iberg A, Wang Z, Li L, Voss C, Jiang X, Lajoie G, Huang Z, Bedford MT, Li SS. Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. J Proteome Res 9(11):5827-5836, 2010. e-Pub 2010. PMID: 20836566.
Yang Y, Lu Y, Espejo A, Wu J, Xu W, Liang S, Bedford MT. TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell 40(6):1016-23, 2010. e-Pub 2010. PMID: 21172665.
Ludes-Meyers, J, Kil, H, Parker-Thornburg, J, Kusewitt, DF, Bedford, MT, Aldaz, CM. Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PloS one 4(11), 2009. e-Pub 2009. PMID: 19936220.
Quinn, AM, Bedford, MT, Espejo, A, Spannhoff, A, Austin, CP, Oppermann, U, Simeonov, A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic acids research 38(2):e11.1-e11.10, 2009. e-Pub 2009. PMID: 19897549.
Lu, M, Yang, J, Ren, Z, Sabui, S, Espejo, A, Bedford, MT, Jacobson, RH, Jeruzalmi, D, McMurray, JS, Chen, X. Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150. Journal of Molecular Biology 393(2):397-408, 2009. e-Pub 2009. PMID: 19660470.
Bua, DJ, Kuo, AJ, Cheung, P, Liu, CL, Migliori, V, Espejo, A, Casadio, F, Bassi, C, Amati, B, Bedford, MT, Guccione, E, Gozani, O. Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PloS one 4(8), 2009. e-Pub 2009. PMID: 19956676.
Repass JF, Laurent MN, Carter C, Reizis B, Bedford MT, Cardenas K, Narang P, Coles M, Richie ER. IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: New tools for analysis of IL-7 expressing cells. Genesis 47(4):281-7, 2009. e-Pub 2009. PMID: 19263498.
Dacwag CS, Bedford MT, Sif S, Imbalzano AN. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol 29(7):1909-21, 2009. e-Pub 2009. PMID: 19188441.
Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem 284(14):9199-205, 2009. e-Pub 2009. PMID: 19144646.
Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol 16(3):312-7, 2009. e-Pub 2009. PMID: 19219047.
Herrmann F, Pably P, Eckerich C, Bedford MT, Fackelmayer FO. Human protein arginine methyltransferases in vivo–distinct properties of eight canonical members of the PRMT family. J Cell Sci 122(Pt 5):667-77, 2009. e-Pub 2009. PMID: 19208762.
Zagurovskaya M, Shareef MM, Das A, Reeves A, Gupta S, Sudol M, Bedford MT, Prichard J, Mohiuddin M, Ahmed MM. EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Oncogene 28(8):1121-31, 2009. e-Pub 2009. PMID: 19137013.
Ito, T, Yadav, N, Lee, J, Furumatsu, T, Yamashita, S, Yoshida, K, Taniguchi, N, Hashimoto, M, Tsuchiya, M, Ozaki, T, Lotz, M, Bedford, MT, Asahara, H. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Developmental Biology 9(1), 2009. e-Pub 2009. PMID: 19725955.
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 22(15):2048-61, 2008. e-Pub 2008. PMID: 18676810.
Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L. Epigenetic multiple ligands: Mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem 51(7):2279-90, 2008. e-Pub 2008. PMID: 18348515.
Hassa PO, Covic M, Bedford MT, Hottiger MO. Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol 377(3):668-78, 2008. e-Pub 2008. PMID: 18280497.
Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep 9(2):193-8, 2008. e-Pub 2008. PMID: 18188184.
Iberg AN, Espejo A, Cheng D, Kim D, Michaud-Levesque J, Richard S, Bedford MT. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem 283(6):3006-10, 2008. e-Pub 2008. PMID: 18077460.
Ludes-Meyers, J, Kil, H, Nunez, MI, Conti, CJ, Parker-Thornburg, J, Bedford, MT, Aldaz, CM. Wwox hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes and Cancer 46(12):1129-1136, 2007. e-Pub 2007. PMID: 17823927.
Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem 282(50):36444-53, 2007. e-Pub 2007. PMID: 17925405.
Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. p53 is regulated by the lysine demethylase LSD1. Nature 449(7158):105-9, 2007. e-Pub 2007. PMID: 17805299.
Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT. Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem 2(7):987-91, 2007. e-Pub 2007. PMID: 17458842.
Swiercz R, Cheng D, Kim D, Bedford MT. Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem 282(23):16917-23, 2007. e-Pub 2007. PMID: 17439947.
Shi, X, Kachirskaia, I, Walter, KL, Kuo, JA, Lake, AN, Davrazou, F, Chan, SM, Martin, DG, Fingerman, IM, Briggs, SD, Howe, LA, Utz, PJ, Kutateladze, TG, Lugovskoy, AA, Bedford, MT, Gozani, O. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. Journal of Biological Chemistry 282(4):2450-2455, 2007. e-Pub 2007. PMID: 17142463.
Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford MT, Torchia J. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol 27(1):120-34, 2007. e-Pub 2007. PMID: 17043108.
Cheng D, Cote J, Shaaban S, Bedford MT. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell 25(1):71-83, 2007. e-Pub 2007. PMID: 17218272.
El Messaoudi S, Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, Sardet C. Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A 103(36):13351-6, 2006. e-Pub 2006. PMID: 16938873.
Sgarra R, Lee J, Tessari MA, Altamura S, Spolaore B, Giancotti V, Bedford MT, Manfioletti G. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem 281(7):3764-72, 2006. e-Pub 2006. PMID: 16293633.
Huang Y, Fang J, Bedford MT, Zhang Y, Xu RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science 312(5774):748-51, 2006. e-Pub 2006. PMID: 16601153.
Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, Zhang Y, Bedford MT. Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep 7(4):397-403, 2006. e-Pub 2006. PMID: 16415788.
Bedford, MT. The family of protein arginine methyltransferases. Enzymes 24(C):31-50, 2006. e-Pub 2006. PMID: 26718036.
Herrmann F, Lee J, Bedford MT, Fackelmayer FO. Dynamics of human protein arginine methyltransferase 1 (PRMT1) in vivo. J Biol Chem 280(45):38005-10, 2005. e-Pub 2005. PMID: 16159886.
Lee J, Sayegh J, Daniel J, Clarke S, Bedford MT. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem 280(38):32890-6, 2005. e-Pub 2005. PMID: 16051612.
Swiercz R, Person MD, Bedford MT. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Biochem J 386(Pt1):85-91, 2005. e-Pub 2005. PMID: 15473865.
Boulanger MC, Liang C, Russell RS, Lin R, Bedford MT, Wainberg MA, Richard S. Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol 79(1):124-31, 2005. e-Pub 2005. PMID: 15596808.
Covic M, Hassa PO, Saccani S, Buerki C, Meier NI, Lombardi C, Imhof R, Bedford MT, Natoli G, Hottiger MO. Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. Embo J 24(1):85-96, 2005. e-Pub 2005. PMID: 15616592.
Sengupta R, Espejo A, Martens J, Bedford MT, Jenuwein T. The tudor domain of 53BP1 facilitates binding to a dimethyl mark on H4-K20. FASEB Summer Research Conferences - Chromatin & Transcription Poster #84:85, 2005. e-Pub 2005.
Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, Aldaz CM. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene 23(29):5049-55, 2004. e-Pub 2004. PMID: 15064722.
Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. J Biol Chem 279(23):23892-9, 2004. e-Pub 2004. PMID: 15056663.
Kim J, Lee J, Yadav N, Wu Q, Carter C, Richard S, Richie E, Bedford MT. Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem 279(24):25339-44, 2004. e-Pub 2004. PMID: 15096520.
Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM, Bedford MT. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A 100(11):6464-8, 2003. e-Pub 2003. PMID: 12756295.
Cote J, Boisvert FM, Boulanger MC, Bedford MT, Richard S. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell 14(1):274-87, 2003. e-Pub 2003. PMID: 12529443.
Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford MT, Aldaz CM. WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res 100(1-4):101-10, 2003. e-Pub 2003. PMID: 14526170.
Espejo A, Cote J, Bednarek A, Richard S, Bedford MT. A protein-domain microarray identifies novel protein-protein interactions. Biochem J 367(Pt3):697-702, 2002. e-Pub 2002. PMID: 12137563.
Liu MY, Cai S, Espejo A, Bedford MT, Walker CL. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res 62(22):6475-80, 2002. e-Pub 2002. PMID: 12438239.
Lee J, Bedford MT. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep 3(3):268-73, 2002. e-Pub 2002. PMID: 11850402.
Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem 277(5):3537-43, 2002. e-Pub 2002. PMID: 11724789.
Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP. Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry 40(48):14585-92, 2001. e-Pub 2001. PMID: 11724572.
Goldstrohm AC, Albrecht TR, Sune C, Bedford MT, Garcia-Blanco MA. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol 21(22):7617-28, 2001. e-Pub 2001. PMID: 11604498.
Passani LA, Bedford MT, Faber PW, McGinnis KM, Sharp AH, Gusella JF, Vonsattel JP, MacDonald ME. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Hum Mol Genet 9(14):2175-82, 2000. e-Pub 2000. PMID: 10958656.
Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW domains. J Biol Chem 275(21):16030-6, 2000. e-Pub 2000. PMID: 10748127.
Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. J Biol Chem 275(14):10359-69, 2000. e-Pub 2000. PMID: 10744724.
Bedford MT, Leder P. The FF domain: a novel motif that often accompanies WW domains. Trends Biochem Sci 24(7):264-5, 1999. e-Pub 1999. PMID: 10390614.
Rentschler S, Linn H, Deininger K, Bedford MT, Espanel X, Sudol M. The WW domain of dystrophin requires EF-hands region to interact with beta-dystroglycan. Biol Chem 380(4):431-42, 1999. e-Pub 1999. PMID: 10355629.
Bedford MT, Reed R, Leder P. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proc Natl Acad Sci U S A 95(18):10602-7, 1998. e-Pub 1998. PMID: 9724750.
Bedford MT, Chan DC, Leder P. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. Embo J 16(9):2376-83, 1997. e-Pub 1997. PMID: 9171351.
Chan DC, Bedford MT, Leder P. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. Embo J 15(5):1045-54, 1996. e-Pub 1996. PMID: 8605874.
Abud HE, Skinner JA, McDonald FJ, Bedford MT, Lonai P, Heath JK. Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge. Dev Genet 19(1):51-65, 1996. e-Pub 1996. PMID: 8792609.
Bedford MT, Arman, E., Orr-Utreger, A, Lonai, P. Analysis of the Howd-3 gene; structure and localization of its sense and natural antisense transcripts. DNA Cell Biol 14(4):295-304, 1995. e-Pub 1995. PMID: 7710686.
Bedford MT, Hecht, D, Zimmerman, N, Avivi, A, Yayon, A. Identification of fibroblast growth factor 9(FGF9) as a high affinity, heparin dependent ligand for FGF receptions 3 and 2 but not for FGF receptors 1 and 4 12(3):223-33, 1995. e-Pub 1995. PMID: 8619928.
Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D, Lonai P. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol 158(2):475-86, 1993. e-Pub 1993. PMID: 8393815.
Orr-Urtreger A, Bedford MT, Do MS, Eisenbach L, Lonai P. Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development 115(1):289-303, 1992. e-Pub 1992. PMID: 1322271.
Bedford MT, van Helden PD. A method to analyze allele-specific methylation. Biotechniques 9(6):744-8, 1990. e-Pub 1990. PMID: 1980196.
Bedford MT, van der Merwe, AJ, Mattheyse, FJ, van Helden, PO, Rossouw, DJ. Allografted keratinocytes used to accelerate the treatment of burn wounds are replaced by recipient cells. Burns 16(3):193-7, 1990. e-Pub 1990. PMID: 2383360.
Bedford MT, van Helden PD. Analysis of allele-specific methylation. Trends Genet 6(5):140-1, 1990. e-Pub 1990. PMID: 1973312.
Bedford MT, van Helden PD. Hypomethylation of DNA in pathological conditions of the human prostate. Cancer Res 47(20):5274-6, 1987. e-Pub 1987. PMID: 2443238.

Invited Articles

Chen J, Sagum C, Bedford MT. Protein domain microarrays as a platform to decipher signaling pathways and the histone code. Methods pii: S1046-2023(19):30137-9. e-Pub 2019.
Bedford MT. Screening for histone codebreakers. J Biol Chem 293(35):13766-13767, 2018. e-Pub 2018. PMID: 30171150.
Barnea, M, Olender, T, Bedford, MT, Elson, A. Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains. Biochemical Society Transactions 44(5):1295-1303, 2016. e-Pub 2016. PMID: 27911712.
Bao J, Bedford MT. Epigenetic regulation of the histone-to-protamine transition during Spermiogenesis. Reproduction 151(5):R55-70, 2016. e-Pub 2016. PMID: 26850883.
Gayatri, S, Bedford, MT. Readers of histone methylarginine marks. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1839(8):702-710, 2014. e-Pub 2014. PMID: 24583552.
Yang Y, Bedford MT. Protein arginine methyltransferases and cancer. Nat Rev Cancer 13(1):37-50, 2013. e-Pub 2013. PMID: 23235912.
Yang Y, Bedford MT. Titivated for destruction: the methyl degron. Mol Cell 48(4):487-8, 2012. e-Pub 2012. PMID: 23200121.
Di Lorenzo, A, Bedford, MT. Histone arginine methylation. FEBS Letters 585(13):2024-2031, 2011. e-Pub 2011. PMID: 21074527.
Bedford, MT, Clarke, S. Protein Arginine Methylation in Mammals. Molecular cell 33(1):1-13, 2009. e-Pub 2009. PMID: 19150423.
Bedford MT. Arginine methylation at a glance. J Cell Sci 120(Pt 24):4243-6, 2007. e-Pub 2007. PMID: 18057026.
Lake AN, Bedford MT. Protein methylation and DNA repair. Mutat Res 618(1-2):91-101, 2007. e-Pub 2007. PMID: 17306845.
Shaaban S, Bedford MT. Reprogramming the histone code. Chem Biol 14(3):242-4, 2007. e-Pub 2007. PMID: 17379139.
Bedford MT, Richard S. Arginine methylation: an emerging regulator of protein function. Mol Cell 18(3):263-72, 2005. e-Pub 2005. PMID: 15866169.
Aasland R, Abrams C, Ampe C, Ball LJ, Bedford MT, Cesareni G, Gimona M, Hurley JH, Jarchau T, Lehto VP, Lemmon MA, Linding R, Mayer BJ, Nagai M, Sudol M, Walter U, Winder SJ. Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett 513(1):141-4, 2002. e-Pub 2002. PMID: 11911894.

Abstracts

Manickavinayaham S, Velez-Cruz R, Biswas AK, Bedford E, Klein BJ, Kutaleladze. E2F1 acetylation regulates DNA double-strand break repair and transcription. 2020 G&E Retreat, 2020. e-Pub 2020.
Manickavinayaham S, Vélez-Cruz R, Biswas AK, Bedford E, Klein BJ, Kutateladze TG, Liu B, Bedford MT, Johnson DG. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. 2019 G&E Retreat, 2019. e-Pub 2019.
Spannhoff A, Bedford MT. Identification of small molecules that counteract epigenetic gene silencing. FASEB Summer Research Conferences - Epigenetics, Chromatin & Transcription Poster #23, 2009. e-Pub 2009.
Spannhoff A, Bedford MT. Identification of small molecules that counteract epigenetic gene silencing. Cancer Epigenomics Workshop Poster #11, 2009. e-Pub 2009.
Spannhoff A, Iberg AN, Espejo A, Bedford MT. Development of novel epigenetic therapies: Identification of small molecule inhibitors of methyl-dependent protein-protein interactions. FASEB Summer Research Conferences-Biological Methylation: From DNA to Histones Poster #40, 2008. e-Pub 2008.
Yang Y, Bedford MT. The functional characterization of TDRD3, a major methylarginine-binding molecule. FASEB Summer Research Conferences-Biological Methylation: From DNA to Histones Poster #47, 2008. e-Pub 2008.
Johnson CL, Houston KD, Bergeron JM, S-L C, Bedford MT, Henske EP, Walker CL. Phosphorylation of T197 regulates the stability and localization of murine p27. Proc Am Assoc Cancer Res 46:5408, 2005. e-Pub 2005.
Yadav N, Lee J, Aldaz M, Bedford MT. Transcriptome analysis of CARM1-/- embryos reveals global changes in gene expression. FASEB Summer Research Conferences - Biological Methylation:A6.2, 2004. e-Pub 2004.
Swiercz R, Bedford MT. Ribosomal protein S2 (PRS2) a new substrate for the protein arginine methyltransferase - PRMT3. FASEB Summer Research Conferences - Biological Methylation:A4, 2004. e-Pub 2004.
Kim J, Lee J, Yadav N, Wu Q, Carter C, Richard S, Richie E, Bedford MT. Loss of CARM1 results in hypomethylation of TARPP and deregulated early T cell development. FASEB Summer Research Conferences – Biological Methylation:A8, 2004. e-Pub 2004.
Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. FASEB Summer Research Conferences - Biological Methylation:A13, 2004. e-Pub 2004.
Espejo A, Bedford MT. A protein-domain microarray identifies novel protein-protein interactions. Proteomics: Technologies and Applications (Keystone Symposia) 304, 2003. e-Pub 2003.
Lee J, Espejo A, Bedford MT. A phospho-regulated switch for 14-3-3 and PDZ domain binding. Lost Pines Conference 217, 2003. e-Pub 2003.
Cheng D, Yadav N, King R, Swanson M, Weinstein E, Bedford MT. Small molecule inhibitors of protein arginine methyltransferases. Lost Pines Conference 207, 2003. e-Pub 2003.
Bedford MT. Finding new signal transduction paradigms with protein-domain microarray. Proteomics in Diabetes:25, 2003. e-Pub 2003.

Book Chapters

Espejo A, Bedford MT. Methylarginine Recognition by Tudor Domains. In: Histone Recognition. Springer, 125-47, 2015.
Cheng D, Vemulapalli V, Bedford MT. Methods applied to the study of protein arginine methylation. In: Methods Enzymol, 71-92, 2012.
Bedford MT. The family of protein arginine methyltransferases. In: Protein Methyltransferases. 3. Elsevier/Academic Press, 2006.
Bedford MT. Methylation of proteins. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer Press, 2006.
Sudol M, Bedford MT. Competitive binding of proline-rich sequences by SH3, WW and other functionally related protein domains. In: Protein Reviews; Proteomics and Protein-Protein interactions. Springer Press, 2005.
Lee J, Cheng D, Bedford MT. Techniques in protein methylation. In: Methods Mol Biol; Signal Transduction Protocols. Humana Press, 195-208, 2004.
Espejo A, Bedford MT. System-oriented proteomics using protein-domain microarrays. In: Protein Arrays. Jones and Bartlett Publishers, 107-18, 2004.
Espejo A, Bedford MT. Protein-domain microarrays. In: Methods Mol Biol; Protein Arrays. Humana Press, 173-81, 2004.

Less

Selected Presentations & Talks

Local Presentations

2023. TBD. Invited. 6th International Conference on Epigenetics and Bioengineering. Virtual, US.
2022. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Invited. 6th International Conference on Epigenetics and Bioengineering. Houston, Texas, US.
2022. PARP1 regulation, Arginine methylation & Protein Domain Arrays (Virtual Seminar). Conference. PARP1 regulation, Arginine methylation & Protein Domain Arrays (Virtual Seminar). Houston, TX, US.
2020. Arginine Methylation: Redundancies & Vulnerabilities (Virtual Seminar). Conference. Arginine Methylation: Redundancies & Vulnerabilities (Virtual Seminar). Houston, TX, US.
2019. Arginine Methylation - Substrates, Effectors & Crosstalk. Conference. Arginine Methylation - Substrates, Effectors & Crosstalk. Houston, TX, US.
2019. Arginine Methylation - From Mechanism to Inhibitors. Conference. Arginine Methylation - From Mechanism to Inhibitors. Houston, TX, US.
2019. Arginine Methylation - From Mechanism to Inhibitors. Conference. Arginine Methylation - From Mechanism to Inhibitors. Houston, TX, US.
2018. Protein Arrays as Tools for Signal Transduction and Small Molecule Discovery. Conference. Houston, Texas, US.
2015. Arginine Methylation – Enzymes, Binders & Inhibitors. Conference. Arginine Methylation – Enzymes, Binders & Inhibitors. Houston, TX, US.
2013. Mechanistic insight into CARM1's coactivator function. Conference. Mechanistic insight into CARM1's coactivator function. Houston, TX, US.
2010. Epigenetic Therapies. Conference. Epigenetic Therapies. Houston, TX, US.
2009. Identifying methyl-dependent interactions and blocking them. Conference. Identifying methyl-dependent interactions and blocking them. Houston, TX, US.

Regional Presentations

2019. Developing Bifunctional PROTAC Probes for Methyl-binding Epigenetic Effectors. Invited. Emerson Collective Awardees Symposium. San Antonio, TX, US.
2018. Methyl Writers and Readers. Conference. Methyl Writers and Readers. Smithville, TX, US.
2017. Arginine Methylation and Protein Domain Microarrays (Keynote Speaker). Conference. Arginine Methylation and Protein Domain Microarrays (Keynote Speaker). Navasota, TX, US.
2017. Arginine Methylation & Protein Domain Microarray. Conference. Arginine Methylation & Protein Domain Microarray. Smithville, TX, US.
2013. Epigenetics and Cancer. Conference. Epigenetics and Cancer. Austin, TX, US.
2010. Arginine methylation and other forms of epigenetic regulation. Conference. Arginine methylation and other forms of epigenetic regulation. Smithville, TX, US.
2007. The Interplay Between Lysine and Arginine Methylation. Conference. The Interplay Between Lysine and Arginine Methylation. Smithville, TX, US.

National Presentations

2023. TBD. Invited. Indianapolis, Indiana, US.
2023. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Conference. Histone and DNA Modifications. Smithville, RI, US.
2023. FASEB Catalyst: Protein Arginine Methylation. Invited. Protein Arginine Methylation in Physiology and Disease. Smithville, Rhode Island, US.
2022. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Conference. The Landscape of Post-Translational Modifications in Tumor Biology Workshop. Zoom Meeting, US.
2022. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Conference. VAI Epigenetics Symposium: 20(+2) Years of the Histone Code. Grand Rapids, MI, US.
2022. Using AlphaFold to predict aromatic cages that bind methyl-marks. Conference. Using AlphaFold to predict aromatic cages that bind methyl-marks. Smithville, TN, US.
2020. Developing Bifunctional PROTAC Probes for Methyl-binding Epigenetic Effectors (Virtual symposium). Conference. Developing Bifunctional PROTAC Probes for Methyl-binding Epigenetic Effectors (Virtual symposium), US.
2019. Arginine methylation - Redundancies and vulnerabilities. Conference. Arginine methylation - Redundancies and vulnerabilities. Seoul.
2019. Using protein domain microarrays as tools for discovery. Conference. Using protein domain microarrays as tools for discovery. Austin, TX, US.
2019. Using protein domain microarrays as tools for discovery. Conference. Using protein domain microarrays as tools for discovery. Telluride, CO, US.
2017. Characterizing and Blocking the H3K4me3 Effector SPIN1. Conference. Characterizing and Blocking the H3K4me3 Effector SPIN1. Houston, TX, US.
2016. The Link Between Arginine Methylation and R-Loop Resolution. Conference. Gordon Research Conference: DNA Damage, Mutation, & Cancer. Ventura, CA, US.
2015. Using protein domain arrays to screen for peptide and chemical ligands. Conference. Society for Laboratory Automation and Screening. Washington, DC, US.
2014. Defining New Histone Reader Domains. Conference. Keystone Symposia on Molecular & Cellular Biology: Cancer Epigenetics & Transcriptional Regulation. Santa Fe, NM, US.
2012. Identifying methyl-arginine substrates and effector modules. Conference. FASEB - Biological Methylation: From DNA and Histones to Disease. Snowmass Village, CO, US.
2012. Identifying methyl-arginine effector molecules and competitors. Conference. 12th Asian Conference on Transcription (ACT 2012). Jeju Island.
2011. Using protein domain microarrays to read the histone code. Conference. Using protein domain microarrays to read the histone code. San Antonio, TX, US.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Conference. TDRD3 is an effector molecule for arginine methylated histone marks. Lake Tahoe, CA, US.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Conference. FASEB Meeting on Biological Methylation. Carefree, AZ, US.
2009. TDRD3 is a major effector molecule of CARM-generated substrates. Conference. Society of Toxicology (SOT). Baltimore, MD, US.
2006. Using proteomic approaches to understand protein methylation. Conference. FASEB Meeting on Biological Methylation. Saxton River, VT, US.
2005. Tudor, MBT and chromo domains gauge the degree of lysine methylation. Conference. FASEB Meeting on Chromatin and Transcription. Snowmass, CO, US.
2005. Making and using protein-domain microarrays. Conference. Society of Toxicology (SOT). New Orleans, LA, US.
2005. Using protein-domain microarrays to identify methyl-binding proteins. Conference. Gordon Research Conference on Toxicogenomics, NH, US.
2005. Using protein-domain microarrays to identify methyl-binding proteins. Conference. Cancer and Chromatin, Arizona Cancer Center. Tucson, AZ, US.
2004. Screening for small molecule inhibitors of protein arginine methyltransferases. Conference. American Chemical Society (Regional). Fort Worth, TX, US.
2004. Using protein-domain microarrays to identify methyl-binding proteins. Conference. FASEB Meeting on Biological Methylation. Saxton River, VT, US.
2004. Analysis of the CARM1 knockout mouse. Conference. Gordon Research Conference on Chromatin Structure & Function (Poster), NH, US.
2003. A functional analysis of the arginine methyltransferase - CARM1. Conference. Center for Research on Environmental Disease Symposium - Experimental Models of Human Disease. Austin, TX, US.
2003. Making and using protein-domain microarrays. Conference. Keystone Symposium Proteomics: Technologies and Applications, (poster). Keystone, CO, US.
2002. Analysis of the CARM1 knockout mouse. Conference. Aspen Cancer Conference, (poster). Aspen, CO, US.
2001. Screening for arginine methyltransferase substrates. Conference. FASEB Meeting on Biological Methylation. Saxton River, VT, US.
1999. Some SH3 domain interactions are regulated by arginine methylation. Conference. FASEB Meeting on Biological Methylation. Saxton River, VT, US.

International Presentations

2023. Biological Role of Histone Lysine Acylation. Invited. Histone and DNA Modifications. Freiburg, US.
2022. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Conference. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Sicily, IT.
2018. Arginine Methylation Substrates, Effectors & Mouse Models. Conference. Arginine Methylation Substrates, Effectors & Mouse Models. Kolkata, IN.
2018. Workshop: Using Protein Domain Microarrays to Characterize Signaling Pathways. Conference. Workshop: Using Protein Domain Microarrays to Characterize Signaling Pathways. Kolkata, IN.
2018. Arginine methylation - Enzyme substrates and overexpression models. Conference. Arginine methylation - Enzyme substrates and overexpression models. Florence, IT.
2016. Novel PRMT5 interactions target it to the plasma membrane. Conference. Novel PRMT5 interactions target it to the plasma membrane. Lisbon, PT.
2015. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Conference. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Marburg, DE.
2015. New CARM1 substrates and PRMT5 interactions. Conference. SGC ChemNet. Toronto, CA.
2014. Arginine Methylation - Enzymes, Readers & Inhibitors. Conference. Histone methyltransferases; Structure, Mechanism and Inhibition. Toronto, CA.
2014. The Biological Role of Arginine Methylation. Conference. FASEB - Biological Methylation: Regulation of Chromatin, Epigenetics, and Disease. Nassau, BS.
2014. Keynote Lecture: Arginine Methylation - Enzymes, Binders & Inhibitors. Conference. ADMA 2014 - Endogenous Modulators of Nitric Oxide: From Mechanisms to Medicines. St. Petersburg, RU.
2014. Defining New Histone Reading Domains & Blocking Them. Conference. COST Conference - Epigenetics: From Bench to Bedside. Athens, GR.
2011. Using protein arrays to read the histone code. Conference. 17th Bijvoet Tutorial Symposium. Utrecht, NL.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Conference. Cold Spring Harbor-Asia. Suzhou, CN.
2010. Recognition mechanisms in epigenetics. Conference. Erice 2010 meeting on CancerOmics. Palermo, IT.
2010. HDACs and Queen Bees. Conference. Structural Genomics Consortium (SGC) Annual Meeting on Epigenetic Chemical Probes. Bellairs, BB.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Conference. AACR Cancer Epigenetics Special Conference. San Juan, PR.
2009. TDRD3 is an effector molecule for CARM1-generated methyl motifs. Conference. Structural Genomics Consortium (SGC) Symposium: Epigenetic Mechanisms in Health and Disease. Toronto, CA.
2009. TDRD3 is a major effector molecule of CARM-generated substrates. Conference. Naito Foundation. Sapporo, JP.
2008. Using proteomic approaches to understand protein methylation. Conference. Spetses Summer School on Chromatin & Transcription. Spetses Island, GR.
2007. Developing and using protein domain microarrays. Conference. FEBS Workshop: The Biology of Modular Protein Domains. Seefeld in Tirol, AT.
2005. The functional analysis of the arginine methyltransferase, CARM1. Conference. Cologne Spring Meeting. Cologne, DE.
2003. Making and using protein-domain microarrays. Conference. Proteomics and Protein Arrays Europa Conference. Copenhagen, DK.

Formal Peers

2023. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Invited. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. College Station, TX, US.
2022. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Invited. The NFIB/CARM1 Partnership in Small Cell Lung Cancer. Indianapolis, IN, US.
2021. Arginine Methylation: Redundancies & Vulnerabilities. Invited. Arginine Methylation: Redundancies & Vulnerabilities. Boston, MA, US.
2021. The three Rs of signaling: Arginine methylation, writers & readers. Invited. The three Rs of signaling: Arginine methylation, writers & readers. Montreal, CA.
2020. Arginine methylation - Redundancies and vulnerabilities. Invited. Arginine methylation - Redundancies and vulnerabilities. Charleston, SC, US.
2019. Arginine methylation - Redundancies and vulnerabilities. Invited. Arginine methylation - Redundancies and vulnerabilities. New York, NY, US.
2019. Arginine Methylation - From Mechanism to Inhibitors. Invited. Arginine Methylation - From Mechanism to Inhibitors. New York, NY, US.
2019. Arginine Methylation - From Mechanism to Inhibitors. Invited. Arginine Methylation - From Mechanism to Inhibitors. Columbus, OH, US.
2019. Arginine methylation: Substrates, effectors, & crosstalk. Invited. Arginine methylation: Substrates, effectors, & crosstalk. Santa Barbara, CA, US.
2018. Arginine Methylation - Substrates, Effectors, & Mouse Models. Invited. Arginine Methylation - Substrates, Effectors, & Mouse Models. Bronx, NY, US.
2018. Arginine Methylation - Substrates, Effectors, & Mouse Models. Invited. Arginine Methylation - Substrates, Effectors, & Mouse Models. Grand Rapids, MI, US.
2016. Epigenetics: From Basics to Drugs. Invited. Epigenetics: From Basics to Drugs. Tacoma, WA, US.
2016. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Milan, IT.
2016. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Salerno, IT.
2016. Protein Arrays as tools for signal transduction and small molecule discovery. Invited. Protein Arrays as tools for signal transduction and small molecule discovery. Ottawa, Ontario, CA.
2016. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. New York, NY, US.
2015. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Los Angeles, CA, US.
2015. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Bethesda, MD, US.
2015. Using protein domain arrays to screen for small molecule inhibitors of epigenetic effectors. Invited. Using protein domain arrays to screen for small molecule inhibitors of epigenetic effectors. Houston, TX, US.
2015. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Rochester, Minnesota, US.
2015. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Duarte, CA, US.
2015. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Invited. Using protein arrays to identify new PRMT5 signaling paradigms & small molecule inhibitors of epigenetic effectors. Houston, TX, US.
2015. Arginine Methylation - Enzymes, Binders & Inhibitors. Invited. Arginine Methylation - Enzymes, Binders & Inhibitors. Edinburg, TX, US.
2014. Arginine Methylation - Enzymes, Binders & Inhibitors. Invited. Arginine Methylation - Enzymes, Binders & Inhibitors. Houston, TX, US.
2014. Arginine Methylation - Enzymes, Binders & Inhibitors. Invited. Arginine Methylation - Enzymes, Binders & Inhibitors. San Diego, CA, US.
2014. Arginine Methylation - Enzymes, Binders & Inhibitors. Invited. Arginine Methylation - Enzymes, Binders & Inhibitors. Austin, TX, US.
2014. Arginine Methylation - A New Enzyme, a New Binder & Inhibitors. Invited. Arginine Methylation - A New Enzyme, a New Binder & Inhibitors. Birmingham, AL, US.
2014. Arginine methylation: Substrates, Binders, & Function. Invited. Arginine methylation: Substrates, Binders, & Function. Boston, MA, US.
2014. Arginine methylation: Enzymes, substrates, & inhibitions. Invited. Arginine methylation: Enzymes, substrates, & inhibitions. Philadelphia, PA, US.
2014. Arginine methylation: Enzymes, substrates, & inhibitions. Invited. Arginine methylation: Enzymes, substrates, & inhibitions. Philadelphia, PA, US.
2014. Arginine methylation: Enzymes, substrates, & inhibitions. Invited. Arginine methylation: Enzymes, substrates, & inhibitions. Los Angeles, CA, US.
2013. Arginine methylation: Enzymes, substrates, and inhibitors. Invited. Arginine methylation: Enzymes, substrates, and inhibitors. Worcester, MA, US.
2013. Arginine methylation: Enzymes, substrates, and inhibitors. Invited. Arginine methylation: Enzymes, substrates, and inhibitors. Bar Harbor, ME, US.
2013. Mechanistic insight into CARM1's coactivator function. Invited. Mechanistic insight into CARM1's coactivator function. Boston, MA, US.
2013. Identifying methyl-arginine effector molecules and competitors. Invited. Identifying methyl-arginine effector molecules and competitors. Munich, DE.
2013. Identifying methyl-arginine effector molecules and competitors. Invited. Identifying methyl-arginine effector molecules and competitors. Munich, DE.
2013. Arginine methylation: Substrates, binders, and function. Invited. Arginine methylation: Substrates, binders, and function. Beverly, MA, US.
2012. Arginine methylation: Substrates, binders, and function. Invited. Arginine methylation: Substrates, binders, and function. Oxford, GB.
2012. Identifying methyl-arginine effector molecules and competitors. Invited. Identifying methyl-arginine effector molecules and competitors. Seoul, KR.
2012. Identifying methyl-arginine effector molecules and competitors. Invited. Identifying methyl-arginine effector molecules and competitors. Suwan, TH.
2011. Identifying methyl-arginine substrates and effector molecules. Invited. Identifying methyl-arginine substrates and effector molecules. Houston, TX, US.
2011. Identifying methyl-arginine substrates and effector molecules. Invited. Identifying methyl-arginine substrates and effector molecules. Chapel Hill, NC, US.
2010. Arginine methylation and other forms of epigenetic regulation. Invited. Arginine methylation and other forms of epigenetic regulation. Houston, TX, US.
2010. Arginine methylation and other forms of epigenetic regulation. Invited. Arginine methylation and other forms of epigenetic regulation. Berlin, DE.
2010. Arginine methylation and other forms of epigenetic regulation. Invited. Arginine methylation and other forms of epigenetic regulation. Houston, TX, US.
2010. Arginine methylation and other forms of epigenetic regulation. Invited. Arginine methylation and other forms of epigenetic regulation. Austin, TX, US.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Invited. TDRD3 is an effector molecule for arginine methylated histone marks. New York, NY, US.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Invited. TDRD3 is an effector molecule for arginine methylated histone marks. Shanghai, CN.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Invited. TDRD3 is an effector molecule for arginine methylated histone marks. Singapore, SG.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Invited. TDRD3 is an effector molecule for arginine methylated histone marks. Rome, IT.
2010. TDRD3 is an effector molecule for arginine methylated histone marks. Invited. TDRD3 is an effector molecule for arginine methylated histone marks. Fisciano, IT.
2010. Characterizing effector molecules (readers) of histone methyl-arginine marks. Invited. Characterizing effector molecules (readers) of histone methyl-arginine marks. Gainesville, FL, US.
2009. TDRD3 is an effector molecule for CARM1-generated methyl motifs. Invited. TDRD3 is an effector molecule for CARM1-generated methyl motifs. Montreal, CA.
2009. Characterizing effector molecules for methylarginine marks. Invited. Characterizing effector molecules for methylarginine marks. Atlanta, GA, US.
2009. Characterizing effector molecules for methylarginine marks. Invited. Characterizing effector molecules for methylarginine marks. Atlanta, GA, US.
2009. TDRD3 is a major effector molecule of CARM-generated substrates. Invited. TDRD3 is a major effector molecule of CARM-generated substrates. Logan, UT, US.
2008. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Pittsburgh, PA, US.
2008. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Danvers, MA, US.
2007. The biological roles of the coactivator associated arginine methyltransferase CARM1. Invited. The biological roles of the coactivator associated arginine methyltransferase CARM1. Buffalo, NY, US.
2007. The biological roles of the coactivator associated arginine methyltransferase CARM1. Invited. The biological roles of the coactivator associated arginine methyltransferase CARM1. London, Ontario, CA.
2007. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Rehovot, IL.
2007. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Irvine, CA, US.
2007. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Ann Arbor, MI, US.
2007. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Los Angeles, CA, US.
2006. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. New York, NY, US.
2006. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Houston, TX, US.
2005. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Atlanta, GA, US.
2005. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Danville, PA, US.
2005. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Rahway, NJ, US.
2005. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. College Station, TX, US.
2005. Using proteomic approaches to understand protein methylation. Invited. Using proteomic approaches to understand protein methylation. Madison, WI, US.
2005. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Ithaca, NY, US.
2005. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Indianapolis, IN, US.
2005. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Berlin, DE.
2004. Using proteomic, genetic and chemical approaches to understand arginine methylation. Invited. Using proteomic, genetic and chemical approaches to understand arginine methylation. Nashville, TN, US.
2004. Using proteomic, genetic and chemical approaches to understand arginine methylation. Invited. Using proteomic, genetic and chemical approaches to understand arginine methylation. Austin, TX, US.
2004. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Long Island, NY, US.
2004. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Princeton, NJ, US.
2004. Using proteomic, genetic and chemical approaches to understand arginine methylation. Invited. Using proteomic, genetic and chemical approaches to understand arginine methylation. Shreveport, LA, US.
2003. Using proteomic, genetic and chemical approaches to understand arginine methylation. Invited. Using proteomic, genetic and chemical approaches to understand arginine methylation. Irvine, CA, US.
2003. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Austin, TX, US.
2003. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Houston, TX, US.
2003. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Houston, TX, US.
2003. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Montreal, CA.
2003. The functional analysis of the arginine methyltransferase, CARM1. Invited. The functional analysis of the arginine methyltransferase, CARM1. Houston, TX, US.
2003. Making and using protein-domain microarrays. Invited. Making and using protein-domain microarrays. San Francisco, CA, US.
2003. Making and using protein-domain microarrays. Invited. Making and using protein-domain microarrays. Palo Alto, CA, US.
2001. Screening for arginine methyltransferase substrates. Invited. Screening for arginine methyltransferase substrates. Houston, TX, US.
2001. Screening for arginine methyltransferase substrates. Invited. Screening for arginine methyltransferase substrates. Austin, TX, US.
2001. A functional analysis of WW domains. Invited. A functional analysis of WW domains. Houston, TX, US.
2000. A functional analysis of WW domains. Invited. A functional analysis of WW domains. Bethesda, MD, US.
1997. A functional analysis of WW domains. Invited. A functional analysis of WW domains. New York, NY, US.

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CV information above last modified March 31, 2025

Mark T. Bedford, Ph.D.

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Mark T. Bedford, Ph.D.

About Dr. Bedford

Present Title & Affiliation

Primary Appointment

Research Interests

Education & Training

Degree-Granting Education

Postgraduate Training

Experience & Service

Academic Appointments

Administrative Appointments/Responsibilities

Other Appointments/Responsibilities

Institutional Committee Activities

Honors & Awards

Professional Memberships

Selected Publications

Peer-Reviewed Articles

Invited Articles

Other Articles

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Book Chapters

Selected Presentations & Talks

Local Presentations

Regional Presentations

National Presentations

International Presentations

Formal Peers

Patient Reviews

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