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Mark Zafereo, MD, FACS

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Head and Neck Surgery, Division of Surgery, University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Faculty Appointment, Baylor College of Medicine, Houston, TX

Bio Statement

Dr. Mark Zafereo received his medical degree from The University of Texas Medical School at Houston and completed his otolaryngology-head and neck surgery residency at Baylor College of Medicine, followed by a fellowship in head and neck surgical oncology at MD Anderson.  Dr. Zafereo is board certified by the American Board of Otolaryngology-Head and Neck Surgery.  He holds national committee appointments for the American Head and Neck Society, American Academy of Otolaryngology-Head and Neck Surgery, and American Board of Otolaryngology-Head and Neck Surgery, and he is current President of the Houston Society of Otolaryngology-Head and Neck Surgery.  He has published over 40 peer-reviewed journal articles, invited articles, and textbook chapters related to cancer and diseases of the head and neck, and speaks nationally and internationally on thyroid cancer and other head and neck cancers.  His clinical interests include thyroid cancer, parathyroid, and other head & neck tumors.

Office Address

University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Houston, TX 77030
Phone: 713-792-6920
Fax: 713-794-4662
University of Texas MD Anderson Cancer Center Sugar Land
1327 Lake Pointe Parkway
Ste. 100
Sugar Land, TX 77478
Phone: 281-566-1800
Fax: 281-566-1801

Education & Training

Degree-Granting Education

2005 University of Texas Medical School, Houston, TX, MD, Doctor of Medicine
2001 University of Texas, Austin, TX, BBA, Highest Honors, Finance

Postgraduate Training

7/2010-6/2011 Clinical Fellowship, Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX
7/2007-6/2010 Clinical Residency, Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX
7/2005-6/2007 Clinical Residency, Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center, Houston, TX

Board Certifications

6/2011 American Board of Otolaryngology

Experience/Service

Administrative Appointments/Responsibilities

Director, Department of Head and Neck Surgery International Visiting Scientist and Observer Program, University of Texas MD Anderson Cancer Center, Houston, TX, 2013-present
Faculty Oversight, Head and Neck Survivorship Clinic, University of Texas MD Anderson Cancer Center, Houston, TX, 2012-2016

Honors and Awards

2015 American Academy of Otolaryngology-Head and Neck Surgery Honor Service Award
2015 American Academy of Otolaryngology-Head and Neck Surgery Young Physicians Spotlight
2015 Tanzanian ENT Society Honorary Member
2014-present America's Top Physicians
2014-present Texas Monthly Top Doctors
2013 American Academy of Otolaryngology-Head and Neck Surgery Holt Leadership Award
2011 American Academy of Otolaryngology-Head and Neck Surgery Foundation Spring Meeting Resident Leadership Grant
2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting Resident Leadership Grant
2010 American Academy of Otolaryngology-Head and Neck Surgery Humanitarian Grant
2010 Global ENT Outreach Farhangi/Asdaghi Scholarship for International Medical Service Projects
2010 Hitoshi Nikaidoh Memorial Humanitarian Grant
2010 Houston Society of Otolaryngology-Head and Neck Surgery Research Award
2010 Texas Association of Otolaryngology Research Award
2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting Resident Leadership Grant
2009 American Association for Cancer Research Scholar-In-Training Award Finalist
2009 Combined Otolaryngology Society Meeting Distinguished Poster and American Head and Neck Society Presidential Citation
2009 Houston Society of Otolaryngology-Head and Neck Surgery Research Award
2009 Houston Surgical Society Research Award
2009 Texas Association of Otolaryngology Research Award
2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting Resident Leadership Grant
2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation Board of Governors Resident Leadership Grant
2008 American Head and Neck Society 7th International Conference on Head and Neck Cancer Grant
2008 Houston Society of Otolaryngology-Head and Neck Surgery Research Award
2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting Resident Leadership Grant
2007 Memorial Hermann Hospital Medical Humanitarian Grant
2005 Alpha Omega Alpha Honor Medical Society
2002 M.D. Anderson Cancer Center Summer Research Program Grant
2001 University of Texas Magna cum Laude, University Honors

Professional Memberships

American Academy of Otolaryngology-Head and Neck Surgery
International Advisory Board Nominating Committee, 2016-present
Consultant, Humanitarian Efforts Committee, 2015-present
Endocrine Surgery Committee, 2015-present
International Activities Task Force, 2015-present
Development Committee, 2014-present
Committee Review Task Force, 2014-2015
International Coordinator for Young Physicians, 2012-present
International Steering Committee, 2012-present
Chair, Section for Residents and Fellows, 2010-2011
Member, Humanitarian Efforts Committee, 2009-2015
Vice Chair, Section for Residents and Fellows, 2009-2010
Board of Governors Public Relations Representative, 2007-2008
Member, 2006-present
American Academy of Otolaryngology-Head and Neck Surgery Foundation Millennium Society
Member, 2010
American Board of Otolaryngology
Task Force on New Materials, 2014-present
Diplomat, 2011
American College of Surgeons
Fellow, 2013-present
Associate Fellow, 2012-2013
American Head and Neck Society
Humanitarian Committee Chair, 2016-present
Endocrine Committee, 2015-present
Survivorship Committee, 2014-present
Humanitarian Committee, 2013-present
Member, 2008-present
American Medical Association
Member, 2001-present
American Thyroid Association
Member, 2014-present
Harris County Medical Society
Member, 2001-present
Houston Society of Otolaryngology-Head and Neck Surgery
President, 2015-2016
Vice President, 2014-2015
Secretary/Treasurer, 2013-2014
Member, 2006-present
Texas Medical Association
Member, 2001-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Gitomer SA, Hutcheson KA, Christianson BL, Samuelson MB, Barringer DA, Roberts DB, Hessel AC, Weber RS, Lewin JS, Zafereo ME. Influence of timing, radiation, and reconstruction on complications and speech outcomes with tracheoesophageal puncture. Head Neck. e-Pub 7/2016. PMID: 27394060.
2. Takiar V, Garden AS, Ma D, Morrison WH, Edson M, Zafereo ME, Gunn GB, Fuller CD, Beadle B, Frank SJ, William WN, Kies M, El-Naggar AK, Weber R, Rosenthal DI, Phan J. Reirradiation of Head and Neck Cancers With Intensity Modulated Radiation Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys 95(4):1117-31, 7/2016. e-Pub 3/2016. PMID: 27354127.
3. Cabanillas ME, Zafereo M, Gunn GB, Ferrarotto R. Anaplastic Thyroid Carcinoma: Treatment in the Age of Molecular Targeted Therapy. J Oncol Pract 12(6):511-8, 6/2016. PMID: 27288464.
4. Zafereo ME, Xu L, Dahlstrom KR, Viamonte CA, El-Naggar AK, Wei Q, Li G, Sturgis EM. Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncol 56:47-53, 5/2016. e-Pub 3/2016. PMCID: PMC4836441.
5. Phan J, Sio TT, Nguyen TP, Takiar V, Gunn GB, Garden AS, Rosenthal DI, Fuller CD, Morrison WH, Beadle B, Ma D, Zafereo ME, Hutcheson KA, Kupferman ME, William WN, Frank SJ. Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys. e-Pub 4/2016. PMID: 27325480.
6. Sandulache VC, Vandelaar LJ, Skinner HD, Cata J, Hutcheson K, Fuller CD, Phan J, Siddiqui Z, Lai SY, Weber RS, Zafereo ME. Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience. Head Neck. e-Pub 2/16/2016. PMID: 26879395.
7. Cata JP, Zafereo M, Villarreal J, Unruh BD, Truong A, Truong DT, Feng L, Gottumukkala V. Intraoperative opioids use for laryngeal squamous cell carcinoma surgery and recurrence: a retrospective study. J Clin Anesth 27(8):672-9, 12/2015. e-Pub 9/2015. PMID: 26371714.
8. Mitani Y, Liu B, Rao P, Borra V, Zafereo M, Weber RS, Kies MS, Lozano G, Futreal A, Caulin C, El-Naggar A. Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clin Cancer Res. e-Pub 12/2015. PMID: 26631609.
9. Tang C, Fuller CD, Garden AS, Awan MJ, Colen RR, Morrison WH, Frank SJ, Beadle BM, Phan J, Sturgis EM, Zafereo ME, Weber RS, Rosenthal DI, Gunn GB. Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response. Oral Oncol 51(2):195-201, 2/2015. e-Pub 11/28/2014. PMID: 25444304.
10. Shehata M, Gombos D, Bishop J, Zafereo ME. Sinonasal melanoma arising from conjunctival primary acquired melanosis. BMJ Case Rep 2015, 2015. e-Pub 2/18/2015. PMID: 25694640.
11. Zhang C, Sturgis EM, Zheng H, Zafereo ME, Wei Q, Li G. TNF-a promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer 135(7):1615-24. doi: 10.1002/ijc.28793., 10/1/2014. e-Pub 2/27/2014. PMCID: PMC4107187.
12. Gan SJ, Dahlstrom KR, Peck BW, Caywood W, Li G, Wei Q, Zafereo ME, Sturgis EM. Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers. Cancer 119(14):2593-601, 7/2013.
13. Peck BW, Dahlstrom KR, Gan SJ, Caywood W, Li G, Wei Q, Zafereo ME, Sturgis EM. Low risk of second primary malignancies among never smokers with human papillomavirus-associated index oropharyngeal cancers. Head Neck 35(6):794-9, 6/2013.
14. Rosenberg TL, Kelley K, Dowdall JR, Replogle WH, Liu JC, Raol NP, Zafereo ME. Section for residents and fellows-in-training survey results. Otolaryngol Head Neck Surg 148(4):582-8, 4/2013.
15. Xu L, Mugartegui L, Li G, Sarlis NJ, Wei Q, Zafereo ME, Sturgis EM. Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans. Mol Carcinog. 51 Suppl 1:E 158-67, 10/2012.
16. Reitzel LR, Nguyen N, Zafereo ME, Li G, Wei Q, Sturgis EM. Neighborhood deprivation and clinical outcomes among head and neck cancer patients. Health Place. Health Place 18(4):861-8, 7/2012.
17. Zhang Y, Sturgis EM, Huang Z, Zafereo ME, Wei Q, Li G. Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck. Cancer 118(2):485-92, 1/2012.
18. Zhang Y, Sturgis EM, Zafereo ME, Wei Q, Li G. p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Cancer 117(6):1227-35, 3/2011.
19. Zafereo ME, Weber RS, Lewin JS, Roberts DB, Hanasono MM. Complications and functional outcomes following complex oropharyngeal reconstruction. Head Neck 32(8):1003-11, 8/2010.
20. Lei D, Sturgis EM, Wang LE, Liu Z, Zafereo ME, Wei Q, Li G. FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev 19(6):1484-91, 6/2010.
21. Li F, Sturgis EM, Chen X, Zafereo ME, Wei Q, Li G. Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck. Cancer 116(10):2350-9, 5/2010.
22. Lei D, Sturgis EM, Liu Z, Zafereo ME, Wei Q, Li G. Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Carcinogenesis 31(2):222-7, 2/2010.
23. Li F, Sturgis EM, Zafereo ME, Liu Z, Wang LE, Wei Q, Li G. p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck. Int J Cancer 125(11):2660-5, 12/2009.
24. Zafereo ME, Hanasono MM, Rosenthal DI, Sturgis EM, Lewin JS, Roberts DB, Weber RS. The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx. Cancer 115(24):5723-33, 12/2009.
25. Chen LM, Li G, Reitzel LR, Pytynia KB, Zafereo ME, Wei Q, Sturgis EM. Matched-pair analysis of race or ethnicity in outcomes of head and neck cancer patients receiving similar multidisciplinary care. Cancer Prev Res (Phila) 2(9):782-91, 9/2009.
26. Zafereo ME, Sturgis EM, Liu Z, Wang LE, Wei Q, Li G. Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Carcinogenesis 30(6):997-1002, 6/2009.
27. Zafereo ME, Sturgis EM, Aleem S, Chaung K, Wei Q, Li G. Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck. Cancer Prev Res (Phila) 2(5):432-9, 5/2009.
28. Zafereo ME, Taylor RJ, Pereira KD. Supraglottoplasty for laryngomalacia with obstructive sleep apnea. Laryngoscope 118(10):1873-7, 10/2008. PMID: 18641529.
29. Zafereo ME, Pereira KD. Chronic retropharyngeal abscess presenting as obstructive sleep apnea. Pediatr Emerg Care 24(6):382-4, 6/2008. PMID: 18562883.
30. Zafereo ME, Fakhri S, Prayson R, Batra PS, Lee J, Lanza DC, Citardi MJ. Esthesioneuroblastoma: 25-year experience at a single institution. Otolaryngol Head Neck Surg 138(4):452-8, 4/2008. PMID: 18359353.
31. Dahlstrom KR, Little JA, Zafereo ME, Lung M, Wei Q, Sturgis EM. Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study. Head Neck 30(1):75-84, 1/2008. PMID: 17694557.
32. Kaszuba SM, Zafereo ME, Rosenthal DI, El-Naggar AK, Weber RS. Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma. Arch Otolaryngol Head Neck Surg 133(6):546-50, 6/2007. PMID: 17576904.

Invited Articles

1. Zafereo M. Surgical salvage of recurrent cancer of the head and neck. Curr Oncol Rep. 16(5):386.doi:10.1007/s11912-014-0386-0, 5/2014. PMID: 24623521.
2. Zafereo ME. Evaluation and staging of squamous cell carcinoma of the oral cavity and oropharynx: limitations despite technological breakthroughs. Otolaryngol Clin North Am 46(4) 46(4):599-613, 8/2013.
Other Articles
1. Zafereo ME. Chronic ear disease in Zanzibar. American Academy of Otolaryngology-Head and Neck Surgery-Bulletin(2):45, 2/2011.
2. Zafereo, ME. The Next Generation of Head and Neck Surgeons: Opportunities and Challenges. American Academy of Otolaryngology-Head and Neck Surgery-Bulletin(1):24, 1/2011.
3. Zafereo, ME. Microtia surgery in Honduras. Academy of Otolaryngology-Head and Neck Surgery-Bulletin(12):45, 12/2010.

Abstracts

1. Mulcahy C, Mohamed AS, Weber R, Lai S, Fuller C, Rosenthal D, El-Naggar A, Hutcheson K, Gunn B, Garden A, Kies M, Lewin J, Morrison W, Zafereo M. Comorbidity and Survival in Locally Advanced Laryngeal Cancer (#161798), 6/2016.

Book Chapters

1. Zafereo ME, Beadle B, Weber RS. Carcinoma Of Oropharynx. In: Head and Neck Cancer Recurrence: Evidence-based Multidisciplinary Management. Ed(s) Hesham Mehanna, Kian Ang. Thieme, 2012.
2. Holsinger FC, Zafereo ME, Chung WY. Robotic Thyroidectomy: A Transaxillary Approach without CO2 Insufflation. In: Cohen & Clayman: Atlas of Head and Neck Surgery. Ed(s) J Cohen, G Clayman, 2011.

Grant & Contract Support

Title: Establishing Dietary Correlates of IGF-1 Ligand Expression in Cancer patients
Funding Source: Riviera Country Club, Orland Park, Illinois
Role: Collaborator
Duration: 2012

Last updated: 8/10/2016