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Michael A Davies, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Assistant Professor, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin Street
Unit Number: 904
Houston, TX 77054
Room Number: SCR2.3019
Email: MDavies@mdanderson.org

Education & Training

Degree-Granting Education

2001 The University of Texas Health Science Center, Houston, TX, MD, PhD, Molecular Biology
1993 The University of Texas at Austin, Austin, TX, BA, Liberal Arts

Postgraduate Training

7/2004-6/2007 Clinical Fellowship, Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2001-6/2004 Clinical Residency, Internal Medicine, Massachusetts General Hospital, Boston, MA

Board Certifications

11/2007 Medical Oncology
8/2004 American Board of Internal Medicine

Professional Memberships

American Association for Cancer Research
Member, 2008-present
American Society of Clinical Oncology
Member, 2004-present
Harris County Medical Association, Houston, TX
Member, 2007-present
The University of Texas-Houston, Houston, TX
Member, 2008-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Bucheit AD, Syklawer E, Jakob JA, Bassett RL, Curry JL, Gershenwald JE, Kim KB, Hwu P, Lazar AJ, Davies MA. Clinical characteristics and outcomes with specific BRAF and NRAS mutations in metastatic melanoma patients. Cancer-Am Cancer Soc, 8/2013.
2. Overman MJ, Zhang J, Kopetz S, Davies MA, Jiang Z, Stemke-Hale K, Hamilton S, Hwang R, Abbruzzese JL, Varadhachary G, Broom B, Wang H. Gene expression profiling of amupllary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome. PLOS One 8(6), e65144, 6/2013. PMCID: PMC3679143.
3. Nathanson KL, Martin AM, Wubbenhorst B, Greshock J, Letrero R, D'Andrea K, O'Day S, Infante JR, Falchook GS, Arkenau HT, Millward M, Brown MP, Pavlick A, Davies MA, Ma B, Gagnon R, Curtis CM, Lebowitz PF, Kefford RF, Long GV. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF ihibitor Dabrafenib (GSK2118436). Clin Cancer Res. e-Pub 6/2013. PMID: 23833299.
4. Joseph RW, Sullivan RJ, Harrell R, Stemke-Hale K, Panka D, Manoukian G, Percy A, Bassett RL, Ng CS, Radvanyi L, Hwu P, Atkins MB, Davies MA. Correlation of NRAS mutations with clinical response to high dose IL-2 in patients with advanced melanoma. J Immunother 35(1):66-72, 1/2012. PMCID: PMCPMC3241890.
5. Bedikian AY, Silverman JA, Papodopolous NE, Kim KB, Hagey AE, Vardeleon A, Hwu WJ, Homsi J, Davies MA, Hwu P. Pharmacokinetics and Safety of Marqibo (Vincristine Sulfate Liposomes Injection) in Cancer Patients with Impaired Liver Function. J Clin Pharmacol 51(8):1205-12, 8/2011. PMID: 20978276.
6. Davies MA, Liu P, McIntyre S, Kim KB, Papadopoulos N, Hwu WJ, Hwu P, Bedikian A. Prognostic Factors for Survival in Melanoma Patients with Brain Metastases. Cancer - Am Cancer Soc 117(8):1687-96, 4/2011. e-Pub 10/2010. PMID: 20960525.
7. Gopal YN, Deng W, Woodman SE, Komurov K, Ram P, Smith PD, Davies MA. Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells. Cancer Res 70(21):8736-8747, 11/2010. e-Pub 10/2010. PMID: 20959481.
8. Altman MK, Gopal V, Jia W, Yu S, Hall H, Mills GB, McGinnis AC, Bartlett MG, Jiang G, Madan D, Prestwich GD, Xu Y, Davies MA, Murph MM. Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Mol Cancer 9:140, 6/2010. PMCID: PMC2895597.
9. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical Association of PDK1 with AKT1 is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase. PLoS One 5(3):e9910, 3/2010. PMCID: PMC2845649.
10. Sikora AG, Gelbard A, Davies MA, Sano D, Ekmekcioglu S, Kwon J, Hailemichael Y, Jayaraman P, Myers JN, Grimm EA, Overwijk WW. Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy. Clin Cancer Res 16(6):1834-44, 3/2010. e-Pub 3/2010. PMCID: PMC2858983.
11. Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA. Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set. Mol Cancer Ther 9(2):257-67, 2/2010. e-Pub 2/2010. PMID: 20124458.
12. Davies MA, Stemke-Hale K, Lin E, Tellez C, Deng W, Gopal YN, Woodman SE, Calderone TC, Ju Z, Lazar AJ, Prieto VG, Aldape K, Mills GB, Gershenwald JE. Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma. Clin Cancer Res 15(24):7538-7546, 12/2009. PMID: 19996208.
13. Torres-Cabala CA, Wang WL, Trent J, Yang D, Chen S, Galbincea J, Kim KB, Woodman S, Davies MA, Plaza JA, Nash JW, Prieto VG, Lazar AJ, Ivan D. Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type. Mod Pathol 22(11):1446-56, 11/2009. e-Pub 8/2009. PMID: 19718013.
14. Woodman SE, Trent JC, Stemke-Hale K, Lazar AJ, Pricl S, Pavan GM, Fermeglia M, Vashisht Gopal YN, Yang D, Podoloff DA, Ivan D, Kim KB, Papadopoulos N, Hwu P, Mills GB, Davies MA. Activity of Dasatinib Against L576P KIT Mutant Melanoma: Molecular, Cellular, and Clinical Correlates. Mol Cancer Ther 8(8):2079-85, 8/2009. e-Pub 8/2009. PMID: 19671763.
15. Vasudevan KM*, Barbie DA*, Davies MA*, Rabinovsky R, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, McNear CJ, Sandy P, Hoesch S, Sheng Q, Gupta P, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA (*contributed equally). AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer *Featured on Cover. Cancer Cell 16(1):21-32, 7/2009. PMID: 19573809.
16. Aziz SA, Davies MA, Pick E, Zito C, Jilaveanu L, Camp RL, Rimm DL, Kluger Y, Kluger HM. Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin Cancer Res 15(9):3029-36, 5/2009. e-Pub 4/2009. PMID: 19383818.
17. Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG, Lazar AJ, Gershenwald JE, Mills GB. A novel AKT3 mutation in melanoma tumours and cell lines. Brit J Cancer 99(8):1265-1268, 9/2008. PMID: 18813315.
18. Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies MA, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT. An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer. Cancer Res 68(15):6084-91, 8/2008. PMID: 18676830.
19. Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK. Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. Oncogene 21(15):2357-2364, 2002. PMID: 11948419.
20. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20(46):6669-78, 10/2001. PMID: 11709701.
21. Beresford SA, Davies MA, Gallick GE, Donato NJ. Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells. J Interferon Cytokine Res 21(5):313-22, 5/2001. PMID: 11429162.
22. Tanaka M, Koul D, Davies MA, Liebert M, Steck PA, Grossman HB. MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells. Oncogene 19(47):5406-5412, 2000. PMID: 11103942.
23. Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 18(50):7034-45, 11/1999. PMID: 10597304.
24. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 59(11):2551-6, 6/1999. PMID: 10363971.
25. Delehedde M, Cho SH, Sarkiss M, Brisbay S, Davies MA, El-Naggar AK, McDonnell TJ. Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer. Cancer 85(7):1514-22, 4/1999. PMID: 10193941.
26. Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, Stokoe D, Yung WK, Mills GB, Steck PA. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res 58(23):5285-90, 12/1998. PMID: 9850049.

Invited Articles

1. Davies MA. The Role of the P13K-AKT Pathway in Melanoma. Cancer J 18(2):142-7, 3/2012. PMID: 22453015.
2. Woodman SE, Davies MA. Targeting KIT in Melanoma: A Paradigm of Molecular Medicine and Targeted Therapeutics. Biochem Pharmacol 80(5):568-74, 9/2010. e-Pub 5/2010. PMID: 20457136.
3. Davies MA, Hennessy B, Mills GB. Point mutations of protein kinases and individualised cancer therapy. Expert Opin Pharmaco 16(16):2243-61, 11/2006. PMID: 17059381.
4. Davies MA. Metastatic renal cell carcinoma: new standards for first-line therapy? Molecular Oncology Report, 2006.

Abstracts

1. Joseph RW, Sullivan RJ, Panka D, Manoukian G, Percy A, Harrell R, Bassett RL, Atkins MB, Hwu P, Davies MA. Effect of mutational status on response, PFS, or OS after the treatment with IL-2 for metastatic melanoma. 2010 ASCO Annual Meeting (#8597), 6/2010.
2. Davies MA, Gershenwald JE. Integrated Analysis of Kinase Signaling Pathways in Melanoma Clinical Specimens. 2009 NCI Translational Meeting, 11/2009.
3. Davies MA, Lee JS. Integrated Analysis of Phospho-Proteins and Gene Expression Profiles Identifies P-GSK3 as a Critical Node in Melanoma. 2009 S.M.R. International Congress Meeting, 11/2009.
4. Kim KB, Davies MA, Papadopoulos NE, Bedikian AY, Hwu W, Woodard K, Washington EW, Dancey JE, Wright J, Hwu P. Phase I/II study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma. ASCO Annual Meeting (#9026), 5/2009.
5. Davies MA, Stemke-Hale K, Calderone T, Deng W, Lazar A, Prieto VG, Aldape K, Mills GB, Gershenwald JE. Quantitative assessment of AKT activation in melanoma. ASCO Annual Meeting (#9022), 5/2009.
6. Woodman SE, Trent JC, Stemke-Hale K, Lazar A, Pricl S, Pavan GM, Papadopoulos N, Hwu P, Mills GB, Davies MA. Selective Activity of Dasatinib for the Most Common KIT Mutation in Melanoma (L576P). ASCO Annual Meeting, 5/2009.
7. *Vasudevan KM, *Barbie DA, *Davies MA, Rabinovsky R, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, McNear CJ, Kim J, Boehm JS, Silver S, Lu Y, Stemke-Hale K, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. PDK1-SGK3 signaling in the absence of AKT activation in PIK3CA-mutant cancers. 2009 AACR Annual Meeting (#3822), 4/2009.
8. Yordy JS, Byers LA, Davies MA, Mills G, Ju Z, Ang KK, Heymach JV. Protein Expression Profiling Identifies Markers of Radiation Sensitivity and Resistance in the NCI 60 Cell Lines. ASCO-NCI-EORTC Annual Meeting, 11/2008.
9. Yordy JS, Byers LA, Davies MA, Molkentine D, Raju U, Mills G, Minna J, Coombes K, Ang KK, Heymach JV. Reverse Phase Protein Arrays Reveal Biomarkers of Radiation Resistance in Head & Neck and Lung Cancer Cell Lines. Translational Advances in Radiation Oncology and Cancer Imaging Symposium, 10/2008.
10. Davies MA, Vasudevan KM, Hennessy BT, Rabinovsky R, Stemke-Hale K, Tseng H, Dutta B, Garraway LA, Mills GB. AKT-independent, PDK1-dependent signaling by oncogenic PIK3CA mutations. AACR Translational Cancer Medicine (#A44), 7/2008.
11. Hwu WJ, Ivan D, Prieto VG, Simon J, Jones D, Ekmekcioglu S, Davies MA, Ayala AE, Garcia ME, Ross M. Randomized phase II neoadjuvant study of temozolomide (TMZ) alone or with pegylated interferon-alfa 2b (PGI) in patients with resectable AJCC stage IIIC or stage IV (M1a) metastatic melanoma. ASCO Annual Meeting (#20024), 5/2008.
12. Kopetz ES, Wu J, Davies MA, Parikh N, Johnson F, Gallick G, and Donato N. Synergistic activity of Src and EGFR inhibitors in colon cancer. AACR Annual Meeting (#4079), 4/2007.
13. Kopetz S, Wu J, Davies MA, Johnson F, and Donato N. Synergistic effects of combination therapy with anti-EGFR and anti-Src therapy in vitro in colon cancer. ASCO Gastrointestinal Cancers Symposium (#406), 2007.
14. Davies MA, Bedikian AY, McIntyre S, Smith T, Kim K, Hwu W, Papadopoulos N, and Hwu P. Natural history of melanoma patients with CNS metastases. ASCO Annual Meeting (#8054), 2006.

Book Chapters

1. Davies MA, Patel S, Kim K. Targeted Therapy in Melanoma. In: Targeted Therapy in Cancer, 1. Ed(s) Kurzrock R, Markman M. Humana Press: Totowa, NJ, 183-211, 2008. ISBN: 978-1-60327-423-4.
2. Davies MA. PTEN, a tumor suppressor gene frequently mutated in glioblastomas. In: Genomic and Molecular Neuro-Oncology. Ed(s) Wei Zhang and Gregory N. Fuller. Jones and Bartlett: Sudbury, MA, 47-61, 2004.

Last updated: 8/26/2013