Patrick M. Dougherty, Ph.D.

Peer-Reviewed Articles

1. Li, Y, Uhelski, ML, North, RY, Elahi, H, Corrales, G, Abercrombie, TJ, Sheffield, KN, Marri, T, Price, TJ, Dougherty, PM. Oncostatin M promotes chronic pain through direct regulation on nociceptors in rats. Pain Publish Ahead of Print, 2026. e-Pub 2026. PMID: 41610043.
2. Kim, SJ, Dougherty, PM, Abdi, S, Javed, S. Quantitative Evaluation of Tonic Spinal Cord Stimulation in Treating Chemotherapy-Induced Peripheral Neuropathy. Neuromodulation 29(1):95-107, 2026. e-Pub 2026. PMID: 41105072.
3. Srikanth, KD, Elahi, H, Chander, P, Washburn, HR, Hassler, S, Mwirigi, JM, Kume, M, Loucks, J, Arjarapu, R, Hodge, R, He, L, Mazhar, K, Shiers, S, Sankaranarayanan, I, Erdjument-Bromage, H, Neubert, TA, Dougherty, PM, Campbell, ZT, Paik, R, Price, TJ, Dalva, MB. The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain. Science 390(6775), 2025. e-Pub 2025. PMID: 41264708.
4. Soliman, N, Moisset, X, Ferraro, MC, Ciampi De Andrade, D, Baron, R, Belton, J, Bennett, DL, Calvo, M, Dougherty, PM, Gilron, I, Hietaharju, A, Hosomi, K, Kamerman, PR, Kemp, H, Enax-Krumova, EK, McNicol, ED, Price, TJ, Raja, SN, Rice, AS, Smith, BH, Talkington, F, Truini, A, Vollert, J, Attal, N, Finnerup, NB, Haroutounian, S, Abuukar Abdullahi, R, Evans, M, Freigang, S, Gwyther, B, Kubota, GT, Phalip, J, Phillips, H, Ramirez Piriz, C, Istri Pramitasuri, T, Rottenberg, A, Hohenschurz-Schmidt, D, Tau-Lim, N, Than, QV, Wandrey, JD, Wang, C, Zachariadis, A, Zunaid, MD. Pharmacotherapy and non-invasive neuromodulation for neuropathic pain. The Lancet Neurology 24(5):413-428, 2025. e-Pub 2025. PMID: 40252663.
5. Li, Y, Uhelski, ML, North, RY, Farson, LB, Bankston, CB, Roland, GH, Fan, DH, Sheffield, KN, Jia, A, Orlando, D, Heles, M, Yaksh, TL, Miller, YI, Kosten, TA, Dougherty, PM. ApoA-I binding protein (AIBP) regulates transient receptor potential vanilloid 1 (TRPV1) activity in rat dorsal root ganglion neurons by selective disruption of toll-like receptor 4 (TLR4)-lipid rafts. Brain, behavior, and immunity 123:644-655, 2025. e-Pub 2025. PMID: 39414176.
6. Li, Y, Uhelski, ML, North, RY, Mwirigi, JM, Tatsui, CE, McDonough, KE, Cata, JP, Corrales, G, Dussor, G, Price, TJ, Dougherty, PM. Tomivosertib reduces ectopic activity in dorsal root ganglion neurons from patients with radiculopathy. Brain 147(9):2991-2997, 2024. e-Pub 2024. PMID: 39046204.
7. Hullugundi, SK, Dolkas, J, Chernov, AV, Yaksh, TL, Eddinger, KA, Angert, M, Catroli, GF, Strongin, AY, Dougherty, PM, Li, Y, Quehenberger, O, Armando, AM, Shubayev, VI. Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments. Brain, Behavior, and Immunity - Health 38, 2024. e-Pub 2024. PMID: 38590761.
8. Kim, HK, Wang, Q, Kim, SH, Dougherty, PM, Wang, J, Abdi, S. Bardoxolone Methyl Ameliorates Chemotherapy-Induced Neuropathic Pain by Activation of Phosphorylated Nuclear Factor Erythroid 2-Related Factor 2 in the Dorsal Root Ganglia. Anesthesia and analgesia 138(3):664-675, 2024. e-Pub 2024. PMID: 38112490.
9. Diaz-delCastillo M, Palasca O, Nemler TT, Thygesen DM, Chávez-Saldaña NA, Vázquez-Mora JA, Ponce Gomez LY, Jensen LJ, Evans H, Andrews RE, Mandal A, Neves D, Mehlen P, Caruso JP, Dougherty PM, Price TJ, Chantry A, Lawson MA, Andersen TL, Jimenez-Andrade JM, Heegaard AM. Metastatic Infiltration of Nervous Tissue and Periosteal Nerve Sprouting in Multiple Myeloma-Induced Bone Pain in Mice and Human. J Neurosci 43(29):5414-5430, 2023. e-Pub 2023. PMID: 37286351.
10. Baruch, EN, Nagarajan, P, Gleber-Netto, FO, Rao, X, Xie, T, Akhter, S, Adewale, A, Shajedul, I, Mattson, BJ, Ferrarotto, R, Wong, MK, Davies, MA, Jindal, S, Basu, S, Harwood, C, Leigh, I, Ajami, NJ, Futreal, A, Castillo, M, Gunaratne, PH, Goepfert, RP, Khushalani, N, Wang, J, Watowich, SS, Calin, GA, Migden, MR, Vermeer, PD, D'Silva, NJ, Yaniv, D, Burks, JK, Gomez, JA, Dougherty, PM, Tsai, KY, Allison, JP, Sharma, P, Wargo, J, Myers, JN, Gross, N, Amit, M. Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade. Research square, 2023. e-Pub 2023. PMID: 37503252.
11. Navia-Pelaez JM, Borges Paes Lemes J, Gonzalez L, Delay L, Dos Santos Aggum Capettini L, Lu JW, Gonçalves Dos Santos G, Gregus AM, Dougherty PM, Yaksh TL, Miller YI. AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons. Pain 164(6):e274-e285, 2023. e-Pub 2023. PMID: 36719418.
12. Kim, DD, DeSnyder, SM, Dougherty, PM, Cata, JP. Effect of neoadjuvant chemotherapy on intraoperative core temperature in patients with breast cancer. BJA Open 5, 2023. e-Pub 2023. PMID: 37587989.
13. Kim DD, DeSnyder SM, Dougherty PM, Cata JP. Effect of neoadjuvant chemotherapy on intraoperative core temperature in patients with breast cancer: a retrospective cohort study. BJA Open 5(C):100119, 2023. e-Pub 2023.
14. Ray PR, Shiers S, Caruso JP, Tavares-Ferreira D, Sankaranarayanan I, Uhelski ML, Li Y, North RY, Tatsui C, Dussor G, Burton MD, Dougherty PM, Price TJ. RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain. Brain 146(2):749-766, 2023. e-Pub 2023. PMID: 35867896.
15. Sauer, AK, Vigouroux, M, Dougherty, PM, Cata, JP, Ingelmo, PM. Pain Experience and Sensory Changes in Astronauts During and After Short-Lasting Commercial Spaceflight. Journal of Pain Research 16:4253-4266, 2023. e-Pub 2023. PMID: 38107368.
16. Ramnarine, SR, Dougherty, PM, Rolke, R, Williams, LJ, Alessi-Fox, C, Coleman, AJ, Longo, C, Colvin, LA, Fallon, MT. The Value of in Vivo Reflectance Confocal Microscopy as an Assessment Tool in Chemotherapy-Induced Peripheral Neuropathy. Oncologist 27(8):E671-E680, 2022. e-Pub 2022. PMID: 35706109.
17. North RY, Odem MA, Li Y, Tatsui CE, Cassidy RM, Dougherty PM, Walters ET. Electrophysiological Alterations Driving Pain-Associated Spontaneous Activity in Human Sensory Neuron Somata Parallel Alterations Described in Spontaneously Active Rodent Nociceptors. J Pain 23(8):1343-1357, 2022. e-Pub 2022. PMID: 35292377.
18. Illias AM, Yu KJ, Hwang SH, Solis J, Zhang H, Velasquez JF, Cata JP, Dougherty PM. Dorsal root ganglion toll-like receptor 4 signaling contributes to oxaliplatin-induced peripheral neuropathy. Pain 163(5):923-935, 2022. e-Pub 2022. PMID: 34490849.
19. Tavares-Ferreira D, Shiers S, Ray PR, Wangzhou A, Jeevakumar V, Sankaranarayanan I, Cervantes AM, Reese JC, Chamessian A, Copits BA, Dougherty PM, Gereau RW, Burton MD, Dussor G, Price TJ. Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors. Sci Transl Med 14(632):eabj8186, 2022. e-Pub 2022. PMID: 35171654.
20. Ramnarine SR, Dougherty PM, Rolke R, Williams LJ, Alessi-Fox C, Coleman AJ, Longo C, Colvin LA, Fallon MT. Is in vivo relectance confocal microscopy a useful tool in chemotherapy-induced peripheral neuropathy?. Oncologist 27(8), 2022. e-Pub 2022.
21. Uhelski ML, Gorur A, Shi T, Corrales G, Du KN, Li Y, Amit M, Tatsui CE, Rhines LD, Dougherty PM, Cata JP. Fadu head and neck squamous cell carcinoma induces hyperexcitability of primary sensory neurons in an in vitro coculture model. Pain Rep 7(3):e1012, 2022. e-Pub 2022. PMID: 35620249.
22. Pennypacker SD, Fonseca MM, Morgan JW, Dougherty PM, Cubillos-Ruiz JR, Strowd RE, Romero-Sandoval EA. Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel. Methods Cell Biol 168:277-298, 2022. e-Pub 2022. PMID: 35366987.
23. Uhelski ML, Li Y, Fonseca MM, Romero-Snadoval EA, Dougherty PM. Role of innate immunity in chemotherapy-induced peripheral neuropathy. Neurosci Lett 755:135941, 2021. e-Pub 2021. PMID: 33961945.
24. Renthal W, Chamessian A, Curatolo M, Davidson S, Burton M, Dib-Hajj S, Dougherty PM, Ebert AD, Gereau RW, Ghetti A, Gold MS, Hoben G, Menichella DM, Mercier P, Ray WZ, Salvemini D, Seal RP, Waxman S, Woolf CJ, Stucky CL, Price TJ. Human cells and networks of pain: Transforming pain target identification and therapeutic development. Neuron 109(9):1426-1429, 2021. e-Pub 2021. PMID: 33957072.
25. Silverman DA, Martinez VK, Dougherty PM, Myers JN, Calin GA, Amit M. Cancer-associated neurogenesis and nerve-cancer crosstalk. Cancer Res 81(6):1431-1440, 2021. e-Pub 2021. PMID: 33334813.
26. Kim HK, Bae J, Lee SH, Hwang SH, Kim MS, Kim MJ, Jun S, Cervantes CL, Jung YS, Back S, Lee H, Lee SE, Dougherty PM, Lee SW, Park JI, Abdi S. Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo. Neurotherapeutics 18(1):601-614, 2021. e-Pub 2021. PMID: 33128175.
27. Cata JP, Patiño M, Lacagnina MJ, Li J, Gorur A, Agudelo-Jimenez R, Wei B, Hagberg CA, Dougherty PM, Shureiqi I, Yang P, Grace PM. A rat model to investigate quality of recovery after abdominal surgery. Pain Rep 6(2):e943, 2021. e-Pub 2021. PMID: 34235345.
28. Li Y, Marri T, North RY, Rhodes HR, Uhelski ML, Abercrombie TJ, Johansson CA, Dougherty PM. Chemotherapy-induced peripheral neuropathy in a dish: dorsal root ganglion cells treated with paclitaxel show biochemical and physiological responses parallel to that seen in vivo. Pain 162(1):84-96, 2021. e-Pub 2021.
29. Shiers S, Ray PR, Wangzhou A, Tatsui CE, Rhines LD, Rao G, Li Y, Uhelski ML, Dougherty PM, Price TJ. ACE2 and SCARF expression in human DRG nociceptors: Implications for SARS-CoV-2 virus neurological effects. Pain 161(11):2492-2501, 2020. e-Pub 2020.
30. Kim HK, Bae J, Lee SH, Hwang SH, Kim MS, Kim MJ, Jun S, Cervantes CL, Jung YS, Back S, Lee H, Lee SE, Dougherty PM, Lee SW, Park JI, Abdi S. Blockers of Wnt3a, Wnt10a, or Catenin prevent chemotherapy-induced neuropathic pain in vivo. Neurotherapeutics, 2020. e-Pub 2020.
31. Viswanathan A, Vendantam A, Williams L, Koyyalagunta D, Abdi S, Dougherty PM, Mendoza T, Bassett RL, Hou P, Bruera E. Percutaneous cordotomy for pain palliation in advanced cancer: A randomized clinical trial study protocol. Neurosurgery 87(2):394-402, 2020. e-Pub 2020.
32. Amit M, Takahashi H, Dragomir MP, Lindemann A, Gieber-Netto F, Pickering C, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman, DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 578:449-454, 2020. e-Pub 2020.
33. Zhang D, Zhou W, Lam TT, Li Y, Duman JG, Dougherty PM, Grosshans DR. Cranial irradiation induces axon initial segment dysfunction and neuronal injury in the prefrontal cortex and impairs hippocampal coupling. Neurooncol. Adv 2(1), 2020. e-Pub 2020.
34. Cata JP, Patino M, Gorur A, Uhelski ML, Li Y, Myers J, Rubin L, Dougherty PM, Owusu-Agyemang P. Persistent and chronic opioid use in a cohort of patients with oral tongue squamous cell carcinoma. Pain Med 21(5):1061-1067, 2020. e-Pub 2020.
35. Gorniac SL, Ochoa N, Cox LIG, Khan A, Ansari S, Thames B, Ray H, Lu YF, Hibino H, Watson N, Dougherty PM. Sex-based differences and aging in tactile function loss in persons with Type 2 diabetes. PLoS One 15(11), 2020. e-Pub 2020.
36. Viswanathan A, Vendantam A, Hess KR, Ochoa J, Dougherty PM, Reddy AS, Koyyalagunta D, Reddy S, Bruera E. Minimally invasive cordotomy for refractory cancer pain: A randomized clinical trial. The Oncologist 24(7):590-596, 2019. e-Pub 2019.
37. Megat S, Ray PR, Moy JK, T-F L, Barragan-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ. Nociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain. J. Neurosci 39(3):393-411, 2019. e-Pub 2019.
38. North RY, Li Y, Rhines LD, Tatsui CE, Rao G, Johannson CA, Zhang H, Dougherty PM. Electrophysiologic and transcriptomic correlates of neuropathic pain in human primary sensory neurons. Brain 142(5):1215-1226, 2019. e-Pub 2019.
39. Vedantam A, Bruera E, Hess KR, Dougherty PM, Viswanathan A. Somatotopy and organization of the spinothalamic tracts in the human cervical spinal cord. Neurosurgery 84(6):311-317, 2019. e-Pub 2019.
40. Dougherty PM. Should we be itching for a CCL2 itch and pain medicine. Brain Behav. Immun 81:12-3, 2019. e-Pub 2019.
41. North RY, Lazaro, TT, Dougherty PM. Ectopic spontaneous afferent activity and neuropathic pain. Neurosurgery 65:49-54, 2018. e-Pub 2018.
42. Ma J, Kavelaars A, Dougherty PM, Heijnen CJ. Beyond symptomatic relief for CIPN: targeting the source. Cancer 124:2289-2298, 2018. e-Pub 2018.
43. Singhmar P, Huo XJ, Li Y, Dougherty PM, Mei FC, Cheng X, Heijnen CJ, Kavelaars A. An orally active Epac inhibitor reverses mechanical allodynia and loss of epidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain 159(5):884-893, 2018. e-Pub 2018.
44. Zhang H, Li Y, Yang Q, Liu XG, Dougherty PM. Morphological and physiological plasticity of spinal lamina II GABA neurons is induced by sciatic nerve chronic constriction injury in mice. Front.Cell.Neurosci 12:143, 2018. e-Pub 2018.
45. Am I, Gist AC, Zhang H, Kosturakis AK, Dougherty PM. Chemokine CCL2 and its receptor CCR-2 in dorsal root ganglion contribute to oxaliplatin induced mechanical hypersensitivity. Pain 159(7):1308-1316, 2018. e-Pub 2018.
46. Roldan CJ, Johnson C, Lee SO, Peng A, Dougherty PM, Huh B. Subclinical peripheral neuropathy in patients with head and neck cancer: A quantitative sensory testing (QST) study. Pain Physician 21:E419-E427, 2018. e-Pub 2018.
47. Gewandter JS, Brell J, Cavaletti G, Dougherty PM, Evans S, Howie L, McDermott MP, O’Mara A, Smith AG, Dastros-Pite D, Gauthier LR, Haroutounian S, Jarpe, M, Katz NP, Loprinzi C, Richardson P, Lavoie-Smith EM, Wen PY, Turk DC, Dworkin RH, Freeman R. Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations. Neurology 91(9):403-414, 2018. e-Pub 2018.
48. Zhang D, Zhou W, Lam TT, Weng C, Bronk L, Ma D, Duman JG, Dougherty PM. Radiation induces age-dependent deficits in cortical synaptic plasticity. Neuro Oncol 20(9):1207-1214, 2018. e-Pub 2018.
49. Boyette-Davis JA, Hou S, Abdi S, Dougherty PM. An updated understanding of the mechanisms involved in chemotherapy-induced neuropathy. Pain Manag 8(5):363-375, 2018. e-Pub 2018.
50. Trahan LH, Cox-Martin E, Johnson CE, Dougherty PM, Yu J, Feng L, Cook C, Novy DM. Psychometric Study of the Pain Drawing. J Appl Biobehav Res 22(4), 2017. e-Pub 2017. PMID: 29230086.
51. Li Y, North RY, Rhines LD, Esteves Tatsui C, Rao G, Edwards DD, Cassidy RM, Harrison DS, Johansson CA, Zhang H, Dougherty PM. DRG Voltage-gated Sodium Channel 1.7 is Up-regulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain. J Neurosci 38(5):1124-1136. e-Pub 2017. PMID: 29255002.
52. Vedantam A, Koyyalagunta D, Bruel BM, Dougherty PM, Viswanathan A. Limited Midline Myelotomy for Intractable Visceral Pain: Surgical Techniques and Outcomes. Neurosurgery. e-Pub 2017. PMID: 29165656.
53. Flatters SJL, Dougherty PM, Colvin LA. Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review. Br J Anaesth 119(4):737-749, 2017. e-Pub 2017. PMID: 29121279.
54. Cox-Martin E, Trahan LH, Cox MG, Dougherty PM, Lai EA, Novy DM. Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy. Support Care Cancer 25(6):1873-1879, 2017. e-Pub 2017. PMID: 28124735.
55. Roldan CJ, Song J, Engle MP, Dougherty PM. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Modulate the Function of Myelinated Fibers after Chemotherapy: A Quantitative Sensory Testing Study. Pain Physician 20(4):281-292, 2017. e-Pub 2017. PMID: 28535551.
56. Vedantam A, Hou P, Chi TL, Hess KR, Dougherty PM, Bruera E, Viswanathan A. Postoperative MRI Evaluation of a Radiofrequency Cordotomy Lesion for Intractable Cancer Pain. AJNR Am J Neuroradiol 38(4):835-839, 2017. e-Pub 2017. PMID: 28209581.
57. Li Y, Tatsui CE, Rhines LD, North RY, Harrison DS, Cassidy RM, Johansson CA, Kosturakis AK, Edwards DD, Zhang H, Dougherty PM. Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy. Pain 158(3):417-429, 2017. e-Pub 2017. PMID: 27902567.
58. Vedantam A, Koyyalagunta D, Bruel BM, Dougherty PM, Viswanathan A. Limited midline myelotomy for intractable visceral pain: Surgical techniques and outcomes. Neurosurg, 2017. e-Pub 2017.
59. Li Y, Tatsui CE, Rhines LD, Harrison DS, Cassidy RM, Kosturakis AK, Edwards DD, Zhang H, Dougherty PM. Voltage-gated calcium channels (T-Type) contribute to hyperexcitability in dorsal root ganglion neurons in paclitaxel-induced peripheral neuropathy. Pain 158:417-428, 2017. e-Pub 2017.
60. Chien JH, Korzeniewska A, Colloca L, Campbell C, Dougherty P, Lenz F. Human Thalamic Somatosensory Nucleus (Ventral Caudal - Vc) as a Locus for Stimulation by Inputs From Tactile, Noxious and Thermal Sensors on an Active Prosthesis. Sensors 17(1197):10.3390, 2017. e-Pub 2017.
61. Vendantam A, Hou P, Chi TL, Dougherty, PM, Hess KR, Viswanathan A. Use of Diffusion Tensor Imaging to Quantify Neural Ablation and Evaluate Outcome After Percutaneous Cordotomy for Intractable Pain. Stereotact Funct Neurosurg 95(1):34-39, 2017. e-Pub 2017.
62. Abdi S, Dougherty PM. Chemotherapy-Induced Peripheral Neuropathy: A Challenge for Clinicians. Oncology (Williston Park) 30(11):1030, C3, 2016. e-Pub 2016. PMID: 27854105.
63. Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A. CD8+ T cells and endogenous IL-10 are required for resolution of chemotherapy-induced neuropathic pain. J Neurosci 36(43):11074-11083, 2016. e-Pub 2016. PMID: 27798187.
64. Pachman DR, Qin R, Seisler D, Smith EM, Kaggal S, Novotny P, Ruddy KJ, Lafky JM, Ta LE, Beutler AS, Wagner-Johnston ND, Staff NP, Grothey A, Dougherty PM, Cavaletti G, Loprinzi CL. Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505). Support Care Cancer. e-Pub 2016. PMID: 27534963.
65. Vedantam A, Hou P, Chi L, Dougherty PM, Viswanathan A. 118 Use of Spinal Cord Diffusion Tensor Imaging to Quantify Neural Ablation and Evaluate Outcome After Percutaneous Cordotomy for Intractable Cancer Pain. Neurosurgery 63 Suppl 1:149-50, 2016. e-Pub 2016. PMID: 27399398.
66. Zhang H, Li Y, de Carvalho-Barbosa M, Kavelaars A, Heijnen CJ, Albrecht PJ, Dougherty PM. Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy. J Pain 17(7):775-86, 2016. e-Pub 2016. PMID: 26979998.
67. Dougherty PM. Is Chemotherapy-induced Peripheral Neuropathy More Than Just a Peripheral Nervous System Disorder?. Anesthesiology 124(5):992-3, 2016. e-Pub 2016. PMID: 26978409.
68. Ganz PA, Dougherty PM. Painful Hands and Feet After Cancer Treatment: Inflammation Affecting the Mind-Body Connection. J Clin Oncol 34(7):649-52, 2016. e-Pub 2016. PMID: 26700128.
69. Shah N, Shi Q, Williams LA, Mendoza TR, Wang XS, Reuben JM, Dougherty PM, Bashir Q, Qazilbash MH, Champlin RE, Cleeland CS, Giralt SA. Higher Stem Cell Dose Infusion after Intensive Chemotherapy Does Not Improve Symptom Burden in Older Patients with Multiple Myeloma and Amyloidosis. Biol Blood Marrow Transplant 22(2):226-31, 2016. e-Pub 2016. PMID: 26253006.
70. Williams LJ, Dougherty PM, Fallon MT. A Comparison of Chemotherapy-induced Peripheral Neuropathy Assessment Tools in Patients Receiving Neurotoxic Chemotherapy. J Clin Oncol 34(3_suppl):132, 2016. e-Pub 2016.
71. Wang XS, Shi Q, Dougherty PM, Eng C, Mendoza TR, Williams LA, Fogelman DR, Cleeland CS. Prechemotherapy Touch Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer. Oncology 90(3):127-35, 2016. e-Pub 2016. PMID: 26882477.
72. Abdi S, Dougherty PM. An Invited Commentary on New Practical Approaches to Chemotherapy Induced Neuropathic Pain: Prevention, Assessment, and Treatment. Oncology 30(11), 2016. e-Pub 2016.
73. Mendoza TR, Wang XS, Williams LA, Shi Q, Vichaya EG, Dougherty PM, Thomas SK, Yucel E, Bastida CC, Woodruff JF, Cleeland CS. Measuring Therapy-Induced Peripheral Neuropathy: Preliminary Development and Validation of the Treatment-Induced Neuropathy Assessment Scale. J Pain 16(10):1032-43, 2015. e-Pub 2015. PMID: 26210041.
74. Li Y, Zhang H, Kosturakis AK, Cassidy RM, Zhang H, Kennamer-Chapman RM, Jawad AB, Colomand CM, Harrison DS, Dougherty PM. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy. Brain Behav Immun 49:255-66, 2015. e-Pub 2015. PMID: 26065826.
75. Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q, Kosturakis AK, Cassidy RM, Harrison DS, Cata JP, Sapire K, Zhang H, Kennamer-Chapman RM, Jawad AB, Ghetti A, Yan J, Palecek J, Dougherty PM. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci 35(39):13487-500, 2015. e-Pub 2015. PMID: 26424893.
76. Colvin LA, Dougherty PM. Peripheral neuropathic pain: signs, symptoms, mechanisms, and causes: Are they linked. Br J Anaesth 114(3):361-3, 2015. e-Pub 2015. PMID: 25253232.
77. Robinson CR, Dougherty PM. Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy. Neuroscience 285:1-10, 2015. e-Pub 2015. PMID: 25446343.
78. de Carvalho Barbosa M, Kosturakis AK, Eng C, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Wang XS, Cleeland CS, Dougherty PM. A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy. Cancer Res 74(21):5955-62, 2014. e-Pub 2014. PMID: 25183707.
79. Kosturakis AK, He Z, Li Y, Boyette-Davis JA, Shah N, Thomas SK, Zhang H, Vichaya EG, Wang XS, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Cleeland CS, Dougherty PM. Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density. J Clin Oncol 32(28):3156-62, 2014. e-Pub 2014. PMID: 25154818.
80. Robinson CR, Zhang H, Dougherty PM. Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat. Neuroscience 274:308-17, 2014. e-Pub 2014. PMID: 24905437.
81. Robinson CR, Zhang H, Dougherty PM. Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy. Brain Res 1574:6-13, 2014. e-Pub 2014. PMID: 24949562.
82. Li Y, Zhang H, Zhang H, Kosturakis AK, Jawad AB, Dougherty PM. Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy. J Pain 15(7):712-25, 2014. e-Pub 2014. PMID: 24755282.
83. Zhang H, Dougherty PM. Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathy. Anesthesiology 120(6):1463-75, 2014. e-Pub 2014. PMID: 24534904.
84. Zhang H, Zhang H, Dougherty PM. Dynamic effects of TNF-α on synaptic transmission in mice over time following sciatic nerve chronic constriction injury. J Neurophysiol 110(7):1663-71, 2013. e-Pub 2013. PMID: 23864372.
85. Zhang H, Boyette-Davis JA, Kosturakis AK, Li Y, Yoon SY, Walters ET, Dougherty PM. Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy. J Pain 14(10):1031-44, 2013. e-Pub 2013. PMID: 23726937.
86. Vichaya EG, Wang XS, Boyette-Davis JA, Mendoza TR, He Z, Thomas SK, Shah N, Williams LA, Cleeland CS, Dougherty PM. Subclinical pretreatment sensory deficits appear to predict the development of pain and numbness in patients with multiple myeloma undergoing chemotherapy. Cancer Chemother Pharmacol 71(6):1531-40, 2013. e-Pub 2013. PMID: 23543296.
87. Boyette-Davis JA, Cata JP, Driver LC, Novy DM, Bruel BM, Mooring DL, Wendelschafer-Crabb G, Kennedy WR, Dougherty PM. Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine. Cancer Chemother Pharmacol 71(3):619-26, 2013. e-Pub 2013. PMID: 23228992.
88. Yoon SY, Robinson CR, Zhang H, Dougherty PM. Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity. J Pain 14(2):205-14, 2013. e-Pub 2013. PMID: 23374942.
89. Yoon SY, Patel D, Dougherty PM. Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. Neuroscience 221:214-24, 2012. e-Pub 2012. PMID: 22742905.
90. Boyette-Davis JA, Eng C, Wang XS, Cleeland CS, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Zhang H, Dougherty PM. Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. Clin Cancer Res 18(11):3180-7, 2012. e-Pub 2012. PMID: 22496202.
91. Rosellini W, Casavant R, Engineer N, Beall P, Pierce D, Jain R, Dougherty PM. Wireless peripheral nerve stimulation increases pain threshold in two neuropathic rat models. Exp Neurol 235(2):621-6, 2012. e-Pub 2012. PMID: 22487199.
92. Dougherty PM. Two pains at once: how can you tell which is worse?. Neurosci Lett 513(2):112-3, 2012. e-Pub 2012. PMID: 22326928.
93. Zhang H, Yoon SY, Zhang H, Dougherty PM. Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy. J Pain 13(3):293-303, 2012. e-Pub 2012. PMID: 22285612.
94. Zhang H, Dougherty PM. Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha. J Physiol 589(Pt 18):4511-26, 2011. e-Pub 2011. PMID: 21788348.
95. Boyette-Davis JA, Cata JP, Zhang H, Driver LC, Wendelschafer-Crabb G, Kennedy WR, Dougherty PM. Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients. J Pain 12(9):1017-24, 2011. e-Pub 2011. PMID: 21703938.
96. Boyette-Davis J, Dougherty PM. Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline. Exp Neurol 229(2):353-7, 2011. e-Pub 2011. PMID: 21385581.
97. Boyette-Davis J, Xin W, Zhang H, Dougherty PM. Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline. Pain 152(2):308-13, 2011. e-Pub 2011. PMID: 21145656.
98. Zhang H, Nei H, Dougherty PM. A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha. J Neurosci 30(38):12844-55, 2010. e-Pub 2010. PMID: 20861388.
99. Melisi D, Ossovskaya V, Zhu C, Rosa R, Ling J, Dougherty PM, Sherman BM, Abbruzzese JL, Chiao PJ. Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. Clin Cancer Res 15(20):6367-77, 2009. e-Pub 2009. PMID: 19808866.
100. Zhang H, Xin W, Dougherty PM. Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes. Mol Pain 5:36, 2009. e-Pub 2009. PMID: 19570219.
101. Xin WJ, Weng HR, Dougherty PM. Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation. Mol Pain 5:15, 2009. e-Pub 2009. PMID: 19323820.
102. Cata JP, Weng HR, Dougherty PM. The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats. Brain Res 1229:100-110, 2008. e-Pub 2008. PMID: 18652810.
103. Cata JP, Weng HR, Dougherty PM. Behavioral and electrophysiological studies in rats with cisplatin-induced chemoneuropathy. Brain Res 1230:91-98, 2008. e-Pub 2008. PMID: 18657527.
104. Cata JP, Weng HR, Dougherty PM. Spinal injection of IL-2 or IL-15 produces hyperalgesia in rats. Neurosci. Lett 437(1):45-49, 2008. e-Pub 2008. PMID: 18423867.
105. Garcia JM, Cata JP, Dougherty PM, Smith RG. Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia. Endocrinology 149(2):455-460, 2008. e-Pub 2008. PMID: 17962345.
106. Dougherty PM, Cata JP, Burton AW, Vu K, Weng HR. Dysfunction in multiple primary afferent fiber subtypes revealed by quantitative sensory testing in patients with chronic vincristine-induced pain. J Pain Symptom Manage 33(2):166-179, 2007. e-Pub 2007. PMID: 17280922.
107. Lee JI, Verhagen Metman L, Ohara S, Dougherty PM, Kim JH, Lenz FA. Internal pallidal neuronal activity during mild drug-related dyskinesias in Parkinson's Disease: decreased firing rates and altered firing patterns. J Neurophysiol 97(4):2627-2641, 2007. e-Pub 2007. PMID: 17215512.
108. Cata JP, Weng HR, Burton AW, Villareal H, Giralt S, Dougherty PM. Quantitative sensory findings in patients with bortezomib-induced pain. J Pain 8(4):296-306, 2006. e-Pub 2006. PMID: 17175202.
109. Aravindan N, Cata JP, Hoffman L, Dougherty PM, Riedel BJ, Price KJ, Shaw AD. Effects of isoflurane, pentobarbital, and urethane on apoptosis and apoptotic signal transduction in rat kidney. Acta Anaesthesiol Scand 50(10):1229-1237, 2006. e-Pub 2006. PMID: 16978161.
110. Patel S, Ohara S, Dougherty PM, Gracely RH, Lenz FA. Psychophysical elements of place and modality specificity in the thalamic somatic sensory nucleus (ventral caudal, Vc) of awake humans. J Neurophysiol 92(2):646-659, 2006. e-Pub 2006. PMID: 16192330.
111. Cata JP, Weng HR, Chen JH, Dougherty PM. Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia. Neuroscience 138(1):329-338, 2006. e-Pub 2006. PMID: 16361064.
112. Aravindan N, Cata JP, Dougherty PM, Shaw AD. Effect of fenoldopam on ischemia/reperfusion induced apoptosis. Ren Fail 28(4):337-344, 2006. e-Pub 2006. PMID: 16771250.
113. Weng HR, Aravindan N, Cata JP, Chen JH, Shaw AD, Dougherty PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett 386(1):18-22, 2005. e-Pub 2005. PMID: 15975716.
114. Lee JI, Ohara S, Dougherty PM, Lenz FA. Pain and temperature encoding in the human thalamic somatic sensory nucleus (Ventral caudal): inhibition-related bursting evoked by somatic stimuli. J Neurophysiol 94:1676-87, 2005. e-Pub 2005. PMID: 15901758.
115. Weng HR, Dougherty PM. Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats. Neuroscience 132:823-831, 2005. e-Pub 2005. PMID: 15837142.
116. Cata JP, Weng HR, Dougherty PM. Cyclooxygenase inhibitors and thalidomide ameliorate vincristine-induced hyperalgesia in rats. Cancer Chemother Pharmacol 54:391-397, 2004. e-Pub 2004. PMID: 15235822.
117. Lenz FA, Ohara S, Gracely RH, Dougherty PM, Patel SH. Pain encoding in the human forebrain: binary and analog exteroceptive channels. J Neurosci 24(29):6540-6544, 2004. e-Pub 2004. PMID: 15269265.
118. Dougherty PM, Cata JP, Cordella JV, Burton A, Weng HR. Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain 109(1-2):132-142, 2004. e-Pub 2004. PMID: 15082135.
119. Cata JP, Cordella JV, Burton AW, Hassenbusch SJ, Weng HR, Dougherty PM. Spinal cord stimulation relieves chemotherapy-induced pain: a clinical case report. J Pain Symptom Manage 27(1):72-78, 2004. e-Pub 2004. PMID: 14711471.
120. Chen JH, Weng HR, Dougherty PM. Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin. Neuroscience 126:743-751, 2004. e-Pub 2004. PMID: 15183522.
121. Cleeland CS, Bennett GJ, Dantzer R, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Lee BN. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer 97(11):2919-2925, 2003. e-Pub 2003. PMID: 12767108.
122. Weng HR, Cordella JV, Dougherty PM. Changes in sensory processing in the spinal dorsal horn accompany vincristine-induced hyperalgesia and allodynia. Pain 103:131-138, 2003. e-Pub 2003. PMID: 12749967.
123. Weng HR, Lenz FA, Vierck C, Dougherty PM. Physiological changes in primate somatosensory thalamus induced by deafferentation are dependent on the spinal funiculi that are sectioned and time following injury. Neuroscience 116:1149-1160, 2003. e-Pub 2003. PMID: 12617956.
124. Dougherty PM. Central sensitization and cutaneous hyperalgesia. Semin. Pain Med 1:121-131, 2003. e-Pub 2003.
125. Grabow TS, Dougherty PM. Gabapentin produces dose-dependent antinociception in the orofacial formalin test in the rat. Reg Anesth Pain Med 27(3):277-283, 2002. e-Pub 2002. PMID: 12016601.
126. Weng HR, Dougherty PM. Tuning of membrane properties regulates subliminal synapses in dorsal horn neurons of intact rats. Exp Neurol 175:209-215, 2002. e-Pub 2002. PMID: 12009773.
127. Grabow TS, Dougherty PM. Cervicomedullary intrathecal injection of morphine produces antinociception in the orofacial formalin test in the rat. Anesthesiology 95:1427-1434, 2001. e-Pub 2001. PMID: 11748402.
128. Weng HR, Mansikka H, Winchurch R, Raja SN, Dougherty PM. Sensory processing in the deep spinal dorsal horn of neurokinin-1 receptor knockout mice. Anesthesiology 94:1105-1112, 2001. e-Pub 2001. PMID: 11465604.
129. Raja SN, Dougherty PM. Reversing tissue injury-induced plastic changes in the spinal cord: the search for the magic bullet. Reg Anesth Pain Med 25:1-4, 2000. e-Pub 2000. PMID: 11009226.
130. LaBuda CJ, Cutler TD, Dougherty PM, Fuchs PN. Mechanical and thermal hypersensitivity develops following kainate lesion of the ventral posterior lateral thalamus in rats. Neurosci Lett 290:79-83, 2000. e-Pub 2000. PMID: 10925179.
131. Weng HR, Lee JI, Lenz FA, Schwartz A, Vierck C, Rowland L, Dougherty PM. Functional plasticity in primate somatosensory thalamus following chronic lesion of the ventral lateral spinal cord. Neuroscience 101:393-401, 2000. e-Pub 2000. PMID: 11074162.
132. Dougherty PM, Staats PS. Intraspinal analgesia: From gold to platinum. Anesthesiology 93:1554, 2000. e-Pub 2000.
133. Lee J, Dougherty PM, Antezana D, Lenz FA. Responses of neurons in the region of human thalamic principal somatic sensory nucleus to mechanical and thermal stimuli graded into the painful range. J Comp Neurol 410:541-555, 1999. e-Pub 1999. PMID: 10398047.
134. Lee JI, Hua S, Clatterbuck RE, Moriarity J, Dougherty PM, Lenz FA. Ablative surgery and deep brain stimulation for Parkinson's disease. Neurosurgery 45:417-418, 1999. e-Pub 1999. PMID: 10449092.
135. Zirh A, Reich SG, Dougherty PM, Lenz FA. Stereotactic thalamotomy in the treatment of essential tremor of the upper extremity: reassessment including a blinded measure of outcome. J Neurol Neurosurg Psychiatry 66:772-775, 1999. e-Pub 1999. PMID: 10329753.
136. Lemstra AW, Verhagen Metman L, Lee JI, Dougherty PM, Lenz FA. Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease. Neurosci Lett 267:129-132, 1999. e-Pub 1999. PMID: 10400229.
137. Dougherty PM, Schwartz A, Lenz FA. Responses of primate spinomesencephalic tract cells to intradermal capsaicin. Neuroscience 90:1377-1392, 1999. e-Pub 1999. PMID: 10338305.
138. Zhang ZH, Dougherty PM, Oppenheimer SM. Monkey insular cortex neurons respond to baroreceptive and somatosensory convergent inputs. Neuroscience 94:351-360, 1999. e-Pub 1999. PMID: 10579199.
139. Lenz FA, Suarez JI, Metman LV, Reich SG, Karp BI, Hallett M, Rowland LH, Dougherty PM. Pallidal activity during dystonia: somatosensory reorganization and changes with severity. J Neurol Neurosurg Psychiatry 65:767-770, 1998. e-Pub 1998. PMID: 9810954.
140. Lenz FA, Garonzik IM, Zirh TA, Dougherty PM. Neuronal activity in the region of the thalamic principal sensory nucleus (ventralis caudalis) in patients with pain following amputations. Neuroscience 86:1065-1081, 1998. e-Pub 1998. PMID: 9697114.
141. Lenz FA, Gracely RH, Baker FH, Richardson RT, Dougherty PM. Reorganization of sensory modalities evoked by microstimulation in region of the thalamic principal sensory nucleus in patients with pain due to nervous system injury. J Comp Neurol 399:125-138, 1998. e-Pub 1998. PMID: 9725706.
142. Dougherty PM, Willis WD, Lenz FA. Transient inhibition of responses to thermal stimuli of spinal sensory tract neurons in monkeys during sensitization by intradermal capsaicin. Pain 77:129-136, 1998. e-Pub 1998. PMID: 9766830.
143. Zhang ZH, Dougherty PM, Oppenheimer SM. Characterization of baroreceptor-related neurons in the monkey insular cortex. Brain Res 796:303-306, 1998. e-Pub 1998. PMID: 9689483.
144. Oppenheimer SM, Kulshreshtha N, Lenz FA, Zhang Z, Rowland LH, Dougherty PM. Distribution of cardiovascular related cells within the human thalamus. Clin Auton Res 8:173-179, 1998. e-Pub 1998. PMID: 9651667.
145. Lenz FA, Dougherty PM. Neurons in the human thalamic somatosensory nucleus (Ventralis caudalis) respond to innocuous cool and mechanical stimuli. J Neurophysiol 79:2227-2230, 1998. e-Pub 1998. PMID: 9535983.
146. Dougherty PM, Mittman S, Lenz FA. Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory thalamus. Neurosci Lett 246:17-20, 1998. e-Pub 1998. PMID: 9622197.
147. Hua SE, Lenz FA, Zirh TA, Reich SG, Dougherty PM. Thalamic neuronal activity correlated with essential tremor. J Neurol Neurosurg Psychiatry 64:273-276, 1998. e-Pub 1998. PMID: 9489548.
148. Lenz FA, Dougherty PM. The new version of the thalamic disinhibition hypothesis may explain clinical features that occur in some patients with central pain. Pain Forum 7:20-23, 1998. e-Pub 1998.
149. Hillis AE, Lenz FA, Zirh TA, Dougherty PM, Eckel TS, Jackson K. Hemispatial somatosensory and motor extinction after stereotactic thalamic lesions. Neurocase(4):21-34, 1998. e-Pub 1998.
150. Hua S, Reich SG, Zirh AT, Perry V, Dougherty PM, Lenz FA. The role of the thalamus and basal ganglia in parkinsonian tremor. Mov Disord 13 Suppl 3:40-42, 1998. e-Pub 1998. PMID: 9827593.
151. Suarez JI, Metman LV, Reich SG, Dougherty PM, Hallett M, Lenz FA. Pallidotomy for hemiballismus: efficacy and characteristics of neuronal activity. Ann Neurol 42:807-811, 1997. e-Pub 1997. PMID: 9392582.
152. Lenz FA, Gracely RH, Zirh TA, Leopold DA, Rowland LH, Dougherty PM. Human thalamic nucleus mediating taste and multiple other sensations related to ingestive behavior. J Neurophysiol 77:3406-3409, 1997. e-Pub 1997. PMID: 9212287.
153. Dougherty PM, Li YJ, Lenz FA, Rowland L, Mittman S. Correlation of effects of general anesthetics on somatosensory neurons in the primate thalamus and cortical EEG power. J Neurophysiol 77:1375-1392, 1997. e-Pub 1997. PMID: 9084604.
154. Cameron AA, Cliffer KD, Dougherty PM, Garrison CJ, Willis WD, Carlton SM. Time course of degenerative and regenerative changes in the dorsal horn in a rat model of peripheral neuropathy. J Comp Neurol 379:428-442, 1997. e-Pub 1997. PMID: 9067834.
155. Lenz FA, Gracely RH, Zirh AT, Romanowski AJ, Staats P, Dougherty PM. The sensory-limbic model suggests testable hypotheses about the learned component of the affective dimension of pain. Pain Forum 6:41-43, 1997. e-Pub 1997.
156. Lenz FA, Gracely RH, Zirh AT, Romanowski AJ, Dougherty PM. The sensory-limbic model of pain memory: Connections from thalamus to the limbic system mediate the learned component of the affective dimension of pain. Pain Forum 6:22-41, 1997. e-Pub 1997.
157. Zirh TA, Lenz FA, Reich SG, Dougherty PM. Patterns of bursting occurring in thalamic cells during Parkinsonian tremor. Neuroscience 83:107-121, 1997. e-Pub 1997.
158. Dougherty PM, Li YJ, Lenz FA, Rowland L, Mittman S. Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus. Brain Res 728:267-273, 1996. e-Pub 1996. PMID: 8864493.
159. Lenz FA, Dougherty PM, Traill TA. Thalamic mechanisms of chest pain in the absence of cardiac pathology. Heart 75:429-430, 1996. e-Pub 1996. PMID: 8665328.
160. Lenz FA, Reich SG, Dougherty PM. Single neuron activity in motor thalamus is correlated with EMG activity in movement disorders. In: Advances in Clinical Neurophysiology. Excerpta Medica: Amsterdam:689-693, 1996. e-Pub 1996.
161. Lenz FA, Gracely RH, Romanoski AJ, Hope EJ, Rowland LH, Dougherty PM. Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. Nat Med 1:910-913, 1995. e-Pub 1995. PMID: 7585216.
162. Dougherty PM, Palecek J, Paleckova V, Willis WD. Infusion of substance P or neurokinin A by micro dialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids. Pain 61:411-425, 1995. e-Pub 1995. PMID: 7478684.
163. Lenz FA, Gracely RH, Hope EJ, Baker FH, Rowland LH, Dougherty PM, Richardson RT. The sensation of angina can be evoked by stimulation of the human thalamus. Pain 59:119-125, 1994. e-Pub 1994. PMID: 7854792.
164. Lenz FA, Gracely RH, Rowland LH, Dougherty PM. A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli. Neurosci Lett 180:46-50, 1994. e-Pub 1994. PMID: 7877759.
165. Garrison CJ, Dougherty PM, Carlton SM. GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801. Exp Neurol 129:237-243, 1994. e-Pub 1994. PMID: 7957738.
166. Dougherty PM, Palecek J, Paleckova V, Willis WD. Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin. J Neurophysiol 72:1464-1475, 1994. e-Pub 1994. PMID: 7823080.
167. Palecek J, Paleckova V, Dougherty PM, Willis WD. The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons. Pain 56:261-269, 1994. e-Pub 1994. PMID: 8022620.
168. Palecek J, Paleckova V, Dougherty PM, Willis WD. The effect of phorbol esters on the responses of primate spinothalamic neurons to mechanical and thermal stimuli. J Neurophysiol 71:529-537, 1994. e-Pub 1994. PMID: 8176422.
169. Dougherty PM, Mittmann S, Sorkin LS. Hyperalgesia and amino acids: receptor selectivity based on stimulus intensity and a role for peptides. APS Journal 3:240-248, 1994. e-Pub 1994.
170. Cameron AA, Dougherty PM, Garrison CJ, Willis WD, Carlton SM. The endogenous lectin RL-29 is transynaptically induced in dorsal horn neurons following peripheral neuropathy in the rat. Brain Res 620:64-71, 1993. e-Pub 1993. PMID: 8402200.
171. Garrison CJ, Dougherty PM, Carlton SM. Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic MK-801-treated rats. Brain Res 607:205-214, 1993. e-Pub 1993. PMID: 7683239.
172. Coggeshall RE, Dougherty PM, Pover CM, Carlton SM. Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?. Pain 52:233-242, 1993. e-Pub 1993. PMID: 8384361.
173. Dougherty PM, Palecek J, Willis WD. Does sensitization of responses to excitatory amino acids underlie the psychophysical reports of two modalities on increased sensitivity in zones of secondary hyperalgesia?. APS Journal(2):276-279, 1993. e-Pub 1993.
174. Dafny N, Dougherty PM. Noninvasive subthreshold auricular electrical stimulation reduces the severity of precipitated and abrupt opiate withdrawal. Brain Res Bull 31:491-492, 1993. e-Pub 1993. PMID: 8495373.
175. Palecek J, Dougherty PM, Kim SH, Paleckova V, Lekan H, Chung JM, Carlton SM, Willis WD. Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates. J Neurophysiol 68:1951-1966, 1992. e-Pub 1992. PMID: 1337100.
176. Dougherty PM, Palecek J, Paleckova V, Sorkin LS, Willis WD. The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. J Neurosci 12:3025-3041, 1992. e-Pub 1992. PMID: 1353793.
177. Palecek J, Paleckova V, Dougherty PM, Carlton SM, Willis WD. Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy. J Neurophysiol 67:1562-1573, 1992. e-Pub 1992. PMID: 1321241.
178. Dougherty PM, Willis WD. Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey. J Neurosci 12:883-894, 1992. e-Pub 1992. PMID: 1545244.
179. Dougherty PM, Garrison CJ, Carlton SM. Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat. Brain Res 570:109-115, 1992. e-Pub 1992. PMID: 1319790.
180. Dougherty PM, Sluka KA, Sorkin LS, Westlund KN, Willis WD. Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids. Brain Res Rev 17:1-13, 1992. e-Pub 1992. PMID: 1638273.
181. Sluka KA, Dougherty PM, Sorkin LS, Willis WD, Westlund KN. Neural changes in acute arthritis in monkeys. III. Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord. Brain Res Rev 17:29-38, 1992. e-Pub 1992. PMID: 1379098.
182. Sorkin LS, Westlund KN, Sluka KA, Dougherty PM, Willis WD. Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn. Brain Res Rev 17:39-50, 1992. e-Pub 1992. PMID: 1638274.
183. Westlund KN, Sun YC, Sluka KA, Dougherty PM, Sorkin LS, Willis WD. Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerve. Brain Res Rev 17:15-27, 1992. e-Pub 1992. PMID: 1353392.
184. Garrison CJ, Dougherty PM, Kajander KC, Carlton SM. Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 565:1-7, 1991. e-Pub 1991. PMID: 1723019.
185. Cameron AA, Cliffer KD, Dougherty PM, Willis WD, Carlton SM. Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy. Neurosci Lett 131:249-252, 1991. e-Pub 1991. PMID: 1722299.
186. Dougherty PM, Willis WD. Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of N-methyl-D-aspartic acid and substance P. Pain 47:85-93, 1991. e-Pub 1991. PMID: 1722895.
187. Carlton SM, Dougherty PM, Pover CM, Coggeshall RE. Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy. Neurosci Lett 131:88-92, 1991. e-Pub 1991. PMID: 1791984.
188. Dougherty PM, Willis WD. Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist. Brain Res 542:15-22, 1991. e-Pub 1991. PMID: 1675920.
189. Dougherty PM, Dafny N. Microiontophoretic application of muramyl-dipeptide upon single cortical, hippocampal and hypothalamic neurons in rats. Neuropharmacology 29:973-981, 1990. e-Pub 1990. PMID: 1982342.
190. Dougherty PM, Dafny N. Muramyl-dipeptide, a macrophage-derived cytokine, alters neuronal activity in hypothalamus and hippocampus but not in the dorsal raphe/periaqueductal gray of rats. J Neuroimmunol 28:201-208, 1990. e-Pub 1990. PMID: 2373761.
191. Dougherty PM, Qiao JT, Wiggins RC, Dafny N. Micro iontophoresis of cocaine, desipramine, sulpiride, methysergide, and naloxone in habenula and parafasciculus. Exper Neurol 108:241-246, 1990. e-Pub 1990. PMID: 2351212.
192. Qiao JT, Dougherty PM, Wiggins RC, Dafny N. Effects of microiontophoretic application of cocaine, alone and with receptor antagonists, upon the neurons of the medial prefrontal cortex, nucleus accumbens and caudate nucleus of rats. Neuropharmacology 29:379-385, 1990. e-Pub 1990. PMID: 2342637.
193. Dougherty PM, Dong WQ, Faillace LA, Dafny N. Trans-cranial electrical stimulation attenuates abrupt morphine withdrawal in rats assayed by remote computerized quantification of multiple motor behavior indices. Eur J Pharmacol 175:187-195, 1990. e-Pub 1990. PMID: 2311653.
194. Dougherty PM, Pellis NR, Dafny N. The brain and the immune system: an intact immune system is essential for the manifestation of withdrawal in opiate addicted rats. Neuroscience 36:285-289, 1990. e-Pub 1990. PMID: 2215925.
195. Dafny N, Dougherty PM, Pellis NR. The immune system and opiate withdrawal. Int J Immunopharmacol 11:371-375, 1989. e-Pub 1989. PMID: 2674032.
196. Dougherty PM, Dafny N. Trans-cranial electrical stimulation attenuates the severity of naloxone-precipitated morphine withdrawal in rats. Life Sci 44:2051-2056, 1989. e-Pub 1989. PMID: 2747416.
197. Dougherty PM, Dafny N. Cyclosporine affects central nervous system (CNS) opioid activity via direct and indirect means. Brain Behav Immun 2:242-253, 1988. e-Pub 1988. PMID: 3242657.
198. Dougherty PM, Dafny N. Neuroimmune intercommunication, central opioids, and the immune response to bacterial endotoxin. J Neurosci Res 19:140-148, 1988. e-Pub 1988. PMID: 3343705.
199. Dafny N, Lee JR, Dougherty PM. Immune response products alter CNS activity: interferon modulates central opioid functions. J Neurosci Res 19:130-139, 1988. e-Pub 1988. PMID: 2449543.
200. Dougherty PM, Pearl J, Krajewski KJ, Pellis NR, Dafny N. Differential modification of morphine and methadone dependence by interferon alpha. Neuropharmacology 26:1595-1600, 1987. e-Pub 1987. PMID: 3431662.
201. Dougherty PM, Dafny N. Irradiation exposure modulates central opioid functions. Exp Neurol 98:301-316, 1987. e-Pub 1987. PMID: 3666080.
202. Dougherty PM, Drath DB, Dafny N. Evidence of an immune system to brain communication axis that affects central opioid functions: muramyl peptides attenuate opiate withdrawal. Eur J Pharmacol 141:253-260, 1987. e-Pub 1987. PMID: 2824218.
203. Pellis NR, Kletzly NE, Dougherty PM, Aronowski J, Dafny N. Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats. Life Sci 40:1589-1593, 1987. e-Pub 1987. PMID: 3550348.
204. Dougherty PM, Harper C, Dafny N. The effect of alpha-interferon, cyclosporine A, and radiation-induced immune suppression on morphine-induced hypothermia and tolerance. Life Sci 39:2191-2197, 1986. e-Pub 1986. PMID: 3784774.
205. Dougherty PM, Aronowski J, Samorajski T, Dafny N. Opiate antinociception is altered by immune modification: the effect of interferon, cyclosporine and radiation-induced immune suppression upon acute and long-term morphine activity. Brain Res 385:401-404, 1986. e-Pub 1986. PMID: 3779401.
206. Dougherty, PM, Aronowsk J, Drath D, Dafny N. Evidence of neuro-immunologic interactions: cyclosporine modifies opiate withdrawal by effects on the brain and immune components. J. Neuroimmunol 13:331-342, 1986. e-Pub 1986.
207. Li Y, Uhelski ML, Corrales G, North RY, Tatsui CE, Rhines RD, Rao G, Shiers S, Price TL, Dougherty PM. Oncostatin M produces pain in animals and excites both rodent and human dorsal root ganglion neurons.
208. S-H H, Dougherty PM, Abdi S, Kim HK. Phosphorylated Nrf2 at serine 40 plays an important role in a rat model of chemotherapy-induced neuropathic pain in vivo. Anesthesiology.
209. Li Y, Uhelski ML, North RY, Mwirigi JM, Tatsui CE, Cata JP, Corrales G, Price TJ, Dougherty PM. MNK inhibitor eFT508 (Tomivosertib) suppresses ectopic activity in human dorsal root ganglion neurons from dermatomes with radicular neuropathic pain. Brain.
210. North RY, Odem MA, Li Y, Rhines LD, Tatsui CE, Rao G, Johansson CA, Cassidy RM, Chervu SM, Dougherty PM, Walters ET. Human sensory neurons linked to neuropathic pain exhibit a hyperactive specialization for driving spontaneous pain. Pain.
211. Middleton SJ, Barry AM, Comini M, Ray PR, Shiers S, Themistocleous AC, Uhelski ML, Yan L, Yang X, Dougherty PM, Price TJ, Bennett DL. Studying human nociceptors: From fundamentals to the clinic. Brain.
212. Kim HK, Wang Q, S-H H, Dougherty PM, Wang J, Abdi S. Bardoxolone methyl ameliorates chemotherapy-induced neuropathic pain by activation of phosphorylated Nrf2 in the dorsal root ganglia. Anesth.Analg.
213. Sauer A, Vigouroux M, Dougherty PM, Cata JP, Ingelmo P. Pain in space: Experience and sensory changes in astronauts during and after commercial spaceflight. Space: Sci. Technol.
214. Li Y, Uheliski ML, Navia-Pelaez JM, Tatsui CE, North RY, Bankston CB, Corrales G, Farson LB, Beaton G, Yaksh TL, Miller YI, Dougherty PM. Lipid rafts are increased in pain-associated human dorsal root ganglion and disruption reduces pain-associated neuronal hyper-excitability. Nat Neurosci.
215. Hullugundi SK, Dolkas J, Chernov AV, Yaksh TL, Eddinger KA, Angert M, Strongin AY, Dougherty PM, Li Y, Quehenberger O, Armando A, Shubayev VI. Oxidized cholesterol suppresses neuroimmune activity of estrogen in sensory neurons of both sexes and mitigates pain induced by myelin basic protein fragments. Brain Behav. Immunity.
216. Tavares-Ferreira D, Shiers S, Ray PR, Wangzhou A, Jeevakumar V, Sankaranarayanan I, Chamessian A, Copits BA, Dougherty PM, Gereau RW, IV, Burton MD, Dussor G, Price TJ. Molecular characterization of human dorsal root ganglion (DRG) neuron subtypes by spatial RNA sequencing. Science.

Invited Articles

1. Dougherty PM. What is causing your neuropathy?. Coping 16:November/December, 2006. e-Pub 2006.

Review Articles

1. Allam, AK, Larkin, MB, Patel, IA, Hasen, M, Mears, D, Dougherty, PM, Viswanathan, A. The human spinothalamic tract. Brain Communications 7(3), 2025. e-Pub 2025. PMID: 40574969.
2. Lenz, FA, Dougherty, PM, Meeker, TJ, Saffer, MI, Oishi, K. Neuroscience of the human thalamus related to acute pain and chronic "thalamic" pain. Journal of Neurophysiology 132(6):1756-1778, 2024. e-Pub 2024. PMID: 39412562.
3. Vu, P, McDonough, KE, Dougherty, PM, D'Souza, RS, Javed, S. Psychophysical and Functional Outcomes in Chemotherapy-induced Peripheral Neuropathy After Spinal Cord Stimulation. Neuromodulation 27(8):1305-1320, 2024. e-Pub 2024. PMID: 39078349.
4. Cata JP, Uhelski ML, Gorur A, Bhoir S, Ilsin N, Dougherty PM. The µ-Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence. Adv Biol (Weinh) 6(9):e2200020, 2022. e-Pub 2022. PMID: 35531616.
5. Cata JP, Uhelski ML, Gorur A, Dougherty PM. Nociception and Pain: New Roles for Exosomes. Neuroscientist 28(4):349-363, 2022. e-Pub 2022. PMID: 34166130.
6. Middleton SJ, Barry AM, Comini M, Li Y, Ray PR, Shiers S, Themistocleous AC, Uhelski ML, Yang X, Dougherty PM, Price TJ, Bennett DL. Studying human nociceptors: from fundamentals to clinic. Brain 144(5):1312-1335, 2021. e-Pub 2021. PMID: 34128530.
7. Paice JA, Mulvey M, Bennett M, Dougherty PM, Farrar JT, Mantyh PW, Miaskowski C, Schmidt B, Smith TJ. AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions. J Pain 18(3):233-246, 2017. e-Pub 2017. PMID: 27884691.
8. Kim JH, Dougherty PM, Abdi S. Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy. Gynecol Oncol 136(3):453-9, 2015. e-Pub 2015. PMID: 25584767.
9. Boyette-Davis JA, Walters ET, Dougherty PM. Mechanisms involved in the development of chemotherapy-induced neuropathy. Pain Manag 5(4):285-96, 2015. e-Pub 2015. PMID: 26087973.
10. Gregory NS, Harris AL, Robinson CR, Dougherty PM, Fuchs PN, Sluka KA. An overview of animal models of pain: disease models and outcome measures. J Pain 14(11):1255-69, 2013. e-Pub 2013. PMID: 24035349.
11. Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB. Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Exp Biol Med (Maywood) 236(6):658-71, 2011. e-Pub 2011. PMID: 21565893.
12. Cata JP, Weng HR, Lee BN, Reuben JM, Dougherty PM. Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy. Minerva Anestesiol 72(3):151-169, 2006. e-Pub 2006. PMID: 16493391.
13. Lee BN, Dantzer R, Langley KE, Bennett GJ, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Cleeland CS. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation 11(5):279-292, 2004. e-Pub 2004. PMID: 15316238.
14. Lenz FA, Lee JI, Garonzik IM, Rowland LH, Dougherty PM, Hua SE. Plasticity of pain-related neuronal activity in the human thalamus. Prog Brain Res 129:259-273, 2000. e-Pub 2000. PMID: 11098695.
15. Dougherty PM, Staats PS. Intrathecal drug therapy for chronic pain: from basic science to clinical practice. Anesthesiology 91:1891-1918, 1999. e-Pub 1999. PMID: 10598634.
16. Dougherty PM, Palecek J, Zorn S, Willis WD. Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons. Brain Res Rev 18:227-246, 1993. e-Pub 1993. PMID: 7687919.

Professional Educational Materials

1. Dougherty PM. Section 3, Homeostasis and Hypothalamus II: Hypothalamic Control of Pituitary Hormone Secretion. The University of Texas Health Science Center at Houston, 2006.
2. Dougherty PM. Section 2, Somatosensory Systems. The University of Texas Health Science center at Houston, 2006.
3. Dougherty PM. Section 2, Somatosensory Pathway. The University of Texas Health Science Center at Houston, 2006.
4. Dougherty PM. Section 3, Homeostasis and Hypothalamus IV. Central Control of Food Intake. The University of Texas Health Science Center at Houston, 2006.
5. Dougherty PM. Section 2, Somatosensory Processes. The University of Texas Health Science Center at Houston, 2006.
6. Dougherty PM. Section 3, Homeostasis and Hypothalamus I: Structure and Function. The University of Texas Health Science Center at Houston, 2006.
7. Dougherty PM. Section 3, Homeostasis and Hypothalamus III. Central Control of the Autonomic Nervous System. The University of Texas Health Science Center at Houston, 2006.

Other Articles

1. Copits, BA, Curatolo, M, Dougherty, PM, Gereau IV, RW, Luo, W, Martone, M, Olausson, H, Price, TJ, Renthal, W, Woolf, CJ, Zhao, G Human pain neuroscience and the next generation of pain therapeutics. Neuron 113(9):1304-1306, 2025. PMID: 40339567.

Editorials

1. Lenz, FA, Dougherty, PM, Meeker, TJ, Oishi, K. Behaviors associated with responses to noxious thermal and complex visuosensory stimuli. Journal of Neurophysiology 132(5):1331-1332, 2024. PMID: 39319786.

Abstracts

1. Li Y, North RY, Johansson CA, Dougherty PM. Cytokines Production and MAPK Signaling Downstream to TLR4 Contributes to Paclitaxel-induced Peripheral Sensory Neuron Hyperexcitability in vitro Culture. Soc, Neurosci. Abstr, 2017. e-Pub 2017.
2. Li Y, Edwards DD, Cassidy RM, Harrison DS, Kosturakis AK, Zhang H, Dougherty PM. Contribution of Voltage-gated Sodium Channel 1.7 in Rat in Paclitaxel Induced Peripheral Pain. Soc. Neurosci. Abstr, 2016. e-Pub 2016.
3. Li Y, Zhang H, Kosturakis AK, Dougherty PM. Paclitaxel Sensitizes TRPV1 via Activation of TLR4 Contributing to Chemotherapy Induced Peripheral Neuropathy. Society of Neuroscience Abstract Program No. 242.04/DD14, 2014. e-Pub 2014.
4. Zhang HM, Li Y, Yang Q, Dougherty PM. Morphological and physiological characteristics of a subgroup of GABAergic spinal lamina II neurons in CCI mice. Society of Neuroscience Abstract Program No. 627.06/FF25, 2014. e-Pub 2014.
5. Zhang H, Li Y, Dougherty PM. Activation of nerve growth factor-TrkA signaling in dorsal root ganglion in paclitaxel-induced peripheral neuropathy. Society of Neuroscience Abstract Program No. 267.16/vv5, 2013. e-Pub 2013.
6. Kosturakis A, He Z, Zhang H, Dougherty PM. Evidence of decreased innervation density in multiple myeloma patients with subclinical peripheral neuropathy prior to chemotherapy. Society of Neuroscience Abstract Program No. 539.09/BB5, 2013. e-Pub 2013.
7. Zhang HM, Li Y, Zhang HJ, Kosturakis A, Dougherty PM. Toll-like receptor (TLR) 4 contributes to paclitaxel-induced painful neuropathy. Society of Neuroscience Abstract Program No. 370.14/GGG8, 2013. e-Pub 2013.
8. Robinson CR, Dougherty PM. Astrocytes are activated in the absence of microglial activation in chemotherapy-induced peripheral neuropath models in rats. Society of Neuroscience Abstract Program No. 521.08/G12, 2013. e-Pub 2013.
9. Zhang H, Dougherty PM. Activation of extracellular signal-regulated kinases (ERKs) in satellite glia in dorsal root ganglion by paclitaxel. Society of Neuroscience Abstract Program No. 82.21/LL6, 2012. e-Pub 2012.
10. Robinson CR, Dougherty PM. Astrocytes, but not microglia, are activated during bortezomib and oxaliplatin-induced peripheral neuropathy. Society of Neuroscience Abstract Program No. 67.03/U10, 2012. e-Pub 2012.
11. Dougherty PM, Zhang H, Kosturakis AK. CCR2 knockout mice show reduced behavioral hypersensitivity following peripheral nerve injury but not following peripheral inflammation. Society of Neuroscience Abstract Program No. 786.05/PP15, 2012. e-Pub 2012.
12. Zhang H, Zhang H, Dougherty PM. Pro-inflammatory cytokines reduce the inhibitory inputs to spinal GABAergic neuron. Society of Neuroscience Abstract Program No. 180.07/II5, 2012. e-Pub 2012.
13. Boyette-Davis JA, Dougherty PM. Detection of long-term chemoneuropathy in patients receiving the plant alkaloids Taxol and vincristine. Society of Neuroscience Abstract Program No. 162.09/DD9, 2011. e-Pub 2011.
14. Zhang H, Dougherty PM. Activation of monocyte chemoattractant protein-1 and its receptor chemokine (c-c motif) receptor 2 in dorsal root ganglion by paclitaxel. Society of Neuroscience Abstract Program No. 381.19/QQ21, 2011. e-Pub 2011.
15. Zhang H, Zhang H, Dougherty PM. Reduced effect of TNF-α on the inhibitory synaptic transmission in mice with CCI injury. Society of Neuroscience Abstract Program No. 141.09/E2, 2011. e-Pub 2011.
16. Robinson CR, Boyette-Davis JA, Dougherty PM. Multimodal characterization of Bortezomib-induced peripheral neuropathy. Society of Neuroscience Abstract Program No. 583.20/II20, 2011. e-Pub 2011.
17. S-Y Y, Davis J, Zhang H, Dougherty PM. Multiple cytokines/chemokines induced in dorsal root ganglion and spinal cord during systemic inflammation are blocked by minocycline. Society of Neuroscience Abstract Program No. 73.02/KK28, 2011. e-Pub 2011.
18. S-Y Y, Davis J, Zhang H, Dougherty PM. Multiple cytokines/chemokines induced in dorsal root ganglion and spinal cord during systemic inflammation are blocked by minocycline. Soc Neurosci Abstr, 2010. e-Pub 2010.
19. Zhang H, S-Y Y, Dougherty PM. Paclitaxel-induced acute activation of astrocytes and enhanced expression of monocyte chemoattractant protein-1 in rat spinal cord. IASP, 2010. e-Pub 2010.
20. Zhang H, Dougherty PM. Systemic minocycline treatment preventspaclitaxel-induced downregulation of glial glutamate transporters in rat spinal cord dorsal horn. Soc Neuroscience abstr, 2010. e-Pub 2010.
21. Boyette-Davis JA, Dougherty PM. Quantitative sensory and intra-epidermal nerve fiber density changes in patients with multiple myeloma treated with bortexomib. 13th International Association for the Study of Pain World Congress, 2010. e-Pub 2010.
22. Zhang HJ, Nie H, Dougherty PM. Inhibition of spinal inhibitory synaptic transmission in mice by tumor necrosis factor-a is dependent on P38 mitogen-activated proteint kinase. Neurosci Prgram No. 764.4, 2009. e-Pub 2009.
23. Xin WJ, Weng HR, Dougherty PM. Plasticity of GLAST and GLT-1 glutamate transporter expression in glia and neurons in the spinal dorsal horn following spinal nerve ligation. 2008 Neuroscience Meeting Planner, Society for Neuroscience(Program No. 69.10/KK6), 2008. e-Pub 2008.
24. Dougherty PM, Burton AW, Hamid B, Driver LC, Weng HR. Persistence of chemoneuropathy related pain and sensory dysfunction at long-term re-examination. 2008 Neuroscience Meeting Planner, Society for Neuroscience(Program No. 266.5/EE27), 2008. e-Pub 2008.
25. Zhang HJ, Xin WJ, Weng HR, Dougherty PM. Synaptically evoked amino acid transport currents recorded from spinal dorsal horn astrocytes in rat spinal slices. 2008 Neuroscience Meeting Planner, Society for Neuroscience(Program No. 771.12/MM3), 2008. e-Pub 2008.
26. Dougherty PM, Weng HR. Induction of pro-inflammatory cytokines and activation of NF-kB in DRG and dorsal horn during taxol-induced hyperalgesia. 2007 Abstract Viewer/Itinerary Planner(Program NO.285.6/JJ16), 2007. e-Pub 2007.
27. Dougherty PM, Cata JP, Weng HR. Comparison and contrast of behavioral and spinal neurophysiology responses in rats treated with frontline chemotherapy drugs. 2005 Abstract Viewer/Planner, 11th Congress of Pain, IASP, 2005. e-Pub 2005.
28. Dougherty PM, Cata JC, Weng HR. The effects of chemotherapy on dorsal horn responses to cutaneous stimuli. 2005 Abstract Viewer/Planner Abstracts of the 11th World Congress on Pain, 2005. e-Pub 2005.
29. Aravindan N, Cata JP, Dougherty PM, Shaw AD. Effect of fenoldopam on ischemia/reperfusion induced apoptosis. ASA Annual Meeting Abstract Viewer/Planner(Program No. A291), 2005. e-Pub 2005.
30. Dougherty PM, Mantyh PW, Bennett GJ. Mechanisms of Cancer- and Cancer-Therapy-Induced Pain. Abstracts of the 11th World Congress on Pain, 2005. e-Pub 2005.
31. Weng HR, Chen JH, Cata JP, Dougherty PM. Decrease expression of spinal glial glutamate transporters in rats with chemotherapy (taxol)- induced mechanical hyperalgesia. 2005 Abstract viwer/Planer, 11th World Congress on Pain, IASP, 2005. e-Pub 2005.
32. Chen JH, Weng HR, Dougherty PM. Electrophysiological properties and morphology of different sensory neurons in dorsal horn. . 2004 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 292.5), 2004. e-Pub 2004.
33. Weng HR, Chen JH, Cata JP, Dougherty PM. Inhibition of glutamate transporters increases hind paw withdrawal frequencies and dorsal horn neuronal responses to peripheral stimuli in rats. 2004 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 291.6), 2004. e-Pub 2004.
34. Weng HR, Cata JP, Dougherty P. Glutamate transporters play a key role in sensory transmission of the spinal dorsal horn. J. Pain 5:5, 2004. e-Pub 2004.
35. Cata JP, Weng HR, Dougherty PM. Increased excitability of WDR neurons accompanies paclitaxel-induced hyperalgesia in rats. 2004 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 982.4), 2004. e-Pub 2004.
36. Ralston HJ, Wiley RG, Dougherty P, Weng HR, Cata J, Chen JH, Hopkins SD, Canchola SA, Galo E, Vierck CJ. The effects of chronic deafferentation and ssp-saporin on pain responses, spinal cord neurons and on the structure and function of the somatosensory thalamus (VPL) in the macaque monkey. 2004 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 295.1), 2004. e-Pub 2004.
37. Weng HR, Chen JH, Cata JC, Dougherty PM. Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Abstract Viewer/Itinerary Planner, Society for Neuroscience, 2004. e-Pub 2004.
38. Dougherty PM, Cata JP, Weng HR. Psychophysical findings in patients with chemotherapy-induced neuropathic pain. 2004 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 982.1), 2004. e-Pub 2004.
39. Cordella JV, Weng HR, Dougherty PM. Changes in sensory processing in the spinal dorsal horn of the rat following treatment with cisplatin. 2003 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 696.7), 2003. e-Pub 2003.
40. Dougherty PM, Chen JH, Weng HR. In vitro sensitization of spinal cord dorsal horn: Whole cell patch clamp analysis. 2003 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 587.5), 2003. e-Pub 2003.
41. Weng HR, Dougherty PM. Intradermal capsaicin injection increases C fiber dorsal root reflexes in peripheral cutaneous nerve. 2003 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 587.4), 2003. e-Pub 2003.
42. Cata JP, Weng HR, Dougherty PM. Thalidomide and COX inhibitors ameliorate vincristine-induced hyperalgesia in rats. . 2003 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 178.15), 2003. e-Pub 2003.
43. Chen JH, Weng HR, Dougherty PM. In vitro sensitization of spinal cord dorsal horn: Dorsal root reflex analysis. 2003 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 587.3), 2003. e-Pub 2003.
44. Dougherty PM, Cata JP, Weng HR. Psychophysical studies of chemotherapy-induced peripheral neuropathy. . Abstracts of the 10th World Congress on Pain:1235-P151, 2002. e-Pub 2002.
45. Weng HR, Cata JP, Dougherty PM. Changes of nociceptive behaviors in newborn rats following cutaneous injection of capsaicin or formalin. Abstracts of the 10th World Congress on Pain:1147-P63, 2002. e-Pub 2002.
46. Cordella J, Weng HR, Dougherty PM. Changes in sensory processing in the spinal cord in vincristine induced neuropathy. Abstracts of the 10th World Congress on Pain:1206-P122, 2002. e-Pub 2002.
47. Weng HR, Cordella J, Lee BN Reuben J, Dougherty PM. DNA microarray analysis of gene expression changes in a model of chemotherapy-induced sensory disturbance. 2002 Abstract Viewer/Itinerary Planner, Society for Neuroscience(Program No. 53.13), 2002. e-Pub 2002.
48. Dougherty PM, Weng HR, Burton A, Reddy S. Psychophysical findings in patients with chemotherapy-induced peripheral neuropathy. J. Pain 3(1):17, 2002. e-Pub 2002.
49. Dougherty PM, Cordella J, Weng HR. Chemotherapy induced hypersensivity is accompanied by a decrease in spontaneous locomotor activity. Proc. Soc. Neurosci 27:506.5, 2001. e-Pub 2001.
50. Li YJ, Mittman S, Rowland LH, Lenz FA, Dougherty PM. Excitatory amino acid antagonists attenuate the responses of neurons in the primate sensory thalamus to cutaneous stimuli. Proc. Soc. Neurosci 21:103, 2000. e-Pub 2000.
51. Lenz FA, Rowland LH, Dougherty PM, Lee JI. Sensations evoked by stimulation with bursts of different numbers of stimuli and frequencies in the region of the human thalamic principal somatosensory nucleus. Proc. Soc. Neurosci 26:2105, 2000. e-Pub 2000.
52. Grabow TS, Weng HR, Staats PS, Dougherty PM. Intracisternal/high cervical intrathecal administration of morphine, clonidine or baclofen are antinociceptive in the orofacial formalin test in the rat. . Abstracts of the 9th World Congress on Pain:540, 1999. e-Pub 1999.
53. Dougherty PM, Weng HR. Correlation of biophysical and functional properties of dorsal horn neurons in rats using in vivo whole cell patch clamp. Proc. Soc. Neurosci 25:148, 1999. e-Pub 1999.
54. Dougherty PM, Weng HR. Characterization of receptive field structure of dorsal horn neurons in the intact anesthetized rat using in vivo whole-cell patch clamp, 1999. e-Pub 1999.
55. Weng HR, Mansikka H, Winchurch R, Raja SN, Dougherty PM. Attenuation of “wind-up” of dorsal horn nocicpetive neurons in NK-1 receptor knockout mice. Proc. Soc. Neurosci 25:680, 1999. e-Pub 1999.
56. Weng HR, Dougherty PM. Manipulation of membrane potentials alters response properties of nociceptive specific neurons in the dorsal horn to peripheral natural stimuli: an in vivo whole-cell patch clamp study. :414, 1999. e-Pub 1999.
57. Antezana D, Lee JI, Dougherty PM, Lenz FA. Responses of neurons in the region of human thalamic principal somatic sensory nucleus to mechanical and thermal stimuli graded into the painful range:151, 1999. e-Pub 1999.
58. Grabow TS, Dhesi SS, Weng HR, Dougherty PM. Intracisternal and high cervical intrathecal injection of morphine produces antinociception in the orofacial formalin test in rat. Proc. Soc. Neurosci 25:928, 1999. e-Pub 1999.
59. Weng HR, Dougherty PM, Schwartz A, Rowland L, Lenz FA. Characterization of “wind-up” of STT neurons in the primate. Proc. Soc. Neurosci 24:2081, 1998. e-Pub 1998.
60. Dougherty PM, Weng HR, Dimitriou PD, Schwartz A, Vierck C, Rowland L, Lenz FA. Deafferentation-induced changes in physiological properties of neurons in macaque somatosensory thalamus (VPL) following dorsal column and spinothalamic tract lesions. Proc. Soc. Neurosci 24:2082, 1998. e-Pub 1998.
61. Lee JI, Weng HR, Dougherty PM, Schwartz A, Vierck C, Rowland L, Lenz FA, Campbell JN. Changes of firing patterns in the thalamus in the primate with chronic lesion in the ventrolateral funiculus in the spinal cord. Proc. Soc. Neurosci 24:2082, 1998. e-Pub 1998.
62. Dougherty PM, Weng HR, Rowland LH, Schwartz A, Vierck CJ, Lenz FA. Spinal cord lesion produces long-term alterations of neurophysiological properties of primate thalamic neurons. Proc. Soc. Neurosci 23:159, 1997. e-Pub 1997.
63. Oppenheimer SM, Zhang ZH, Dougherty PM. Convergence of baroreceptive and nociceptive neurons in ht emonkey insular cortex. Proc. Soc. Neurosci 23:423, 1997. e-Pub 1997.
64. Zirh A, Lenz FA, Garonzik IM, Richardson RT, Ringkamp M, Rowland LH, Dougherty PM. Characteristics of neuronal activity in the region of the thalamic nucleus VC in patients with amputations. Proc. Soc. Neurosci 22:1054, 1996. e-Pub 1996.
65. Dougherty PM, Li YJ, Rowland LH, Lenz FA. Sensitization of primate spinomesencephalic neurons by capsaicin is paralleled by facilitation of responses to excitatory amino acids. IASP 8th World Congress Abstracts:40, 1996. e-Pub 1996.
66. Dougherty PM, Rowland LH, Zirh AT, Lenz FA, Schwartz AH. Comparison of effects of intradermal capsaicin on cells in the primate spinal trigeminal and dorsal column nuclei. Proc. Soc. Neurosci 22:868, 1996. e-Pub 1996.
67. Lenz FA, Hillis A, Gracely RH, Rowland LH, Delano MC, Eckel TS, Bryan RN, Dougherty PM. Subtle neglect of a non-painful part of the body in a chronic pain patient reversed by intralaminar thalamotomy. Proc. Soc. Neurosci 22:965, 1996. e-Pub 1996.
68. Lenz FA, Gracely RH, Romanoski AJ, Hope EJ, Rowland LH, Dougherty PM. Pain with a strong affective dimension reproduced by stimulation of the human somatosensory thalamus. Proc. Soc. Neurosci 21:1444, 1995. e-Pub 1995.
69. Kulshreshtha N, Rowland LH, Lawson C, Mao C, Lenz FA, Dougherty PM, Oppenheimer SM. Distribution of cardiovascular related sites within the human thalamus. Proc. Soc. Neurosci 21:637, 1995. e-Pub 1995.
70. Mittman S, Rowland LH, Li YJ, Lenz FA, Dougherty PM. Characterization of the responses of neurons in the primate sensory thalamus to excitatory amino acid agonists. Proc. Soc. Neurosci 21:103, 1995. e-Pub 1995.
71. Dougherty PM, Rowland LH, Li YJ, Lenz FA, Mittman S. Effects of two classes of general anesthetics on responses of neurons in the primate sensory thalamus. Proc. Soc. Neurosci 21:103, 1995. e-Pub 1995.
72. Mittman S, Rowland H, Elliott CD, Dougherty PM. The role of NMDA and Non-NMDA receptors in mediating sensory inputs to rat ventrobasal thalamus. Proc. Soc. Neurosci 20:119, 1994. e-Pub 1994.
73. Dougherty PM, Palecek J, Willis WD. Does sensitization of responses to excitatory amino acids underlie the psychophysical reports of two modalities on increased sensitivity in zones of secondary hyperalgesia? . APS Journal 2:276-279, 1993. e-Pub 1993.
74. Lin YC, Gracely RH, Lenz FA, Baker FH, Rowland LH, Dougherty PM, Richardson RT. Sensations evoked by microstimulation in the area of the ventrocaudal nucleus of thalamus (Vc) in patients with chronic pain. Proc. Soc. Neurosci 19:1572, 1993. e-Pub 1993.
75. Carlton SM, Gondesen K, Palecek J, Rees H, Dougherty PM, Willis WD. Behavioral and electrophysiological consequences of phentolamine administration in neuropathic primates. Proc. Soc. Neurosci 19:520, 1993. e-Pub 1993.
76. Dougherty PM, Palecek J, Paleckova V, Sorkin LS, Willis WD. The role of NMDA, non-NMDA, and NK-1 receptors in the excitation of spinothalamic tract neurons in anesthetized monkeys. J. Physiol 459:209P, 1993. e-Pub 1993.
77. Dougherty PM, Palecek J, Paleckova V, Willis WD. The effects of substance P and neurokinin A on the responses of primate spinothalamic tract neurons following infusion by microdialysis. Proc. 7th World Congress on Pain, Internat. Assoc. for Study of Pain 7:469, 1993. e-Pub 1993.
78. Lenz FA, Gracely RH, Hope E, Baker FH, Rowland LH, Dougherty PM, Richardson RT. Microstimulation in the area of human Vc can evoke the sensation of angina. Proc. Soc. Neurosci 19:1572, 1993. e-Pub 1993.
79. Westlund KN, Sluka KA, Dougherty PM, Sorkin LS, Willis WD. Anatomical, physiological, and released amino acid changes paralleling the generation of acute arthritis in monkeys. International Meeting on Biology:46, 1992. e-Pub 1992.
80. Carlton SM, Kim SH, Lekan H, Palecek J, Paleckova V, Dougherty PM, Chung JM, Willis WD. Analysis of behavioral, electrophysiological and anatomical changes in a primate model of experimental peripheral neuropathy. International Meeting on Biology:66, 1992. e-Pub 1992.
81. Cameron AA, Dougherty PM, Garrison CJ, Willis WD, Carlton SM. The time course of histochemical changes and the transynaptic induction of a 29KD lectin in the dorsal horn in a rat model of neuropathy. . Proc. Soc. Neurosci 18:288, 1992. e-Pub 1992.
82. Palecek J, Dougherty PM, Kim SH, Paleckova V Lekan H, Chung JM, Carlton SM, Willis WD. Responses of spinothalamic tract neurons to mechanical and thermal stimuli are increased in an experimental model of peripheral neuropathy in primates. Proc. Soc. Neurosci 18:287, 1992. e-Pub 1992.
83. Dougherty PM, Palecek J, Paleckova V, Ragland J, Willis WD. Application of trans-ACPD or phorbol esters by microdialysis modifies the background activity and the responses of primate STT neurons to sensory stimuli and to excitatory amino acids. Proc. Soc. Neurosci 18:1023, 1992. e-Pub 1992.
84. Pover CM, Dougherty PM, Carlton SM, Coggeshall RE. Correlation of axonal changes in a rat experimental neuropathy model. . Proc. Soc. Neurosci 18:288, 1992. e-Pub 1992.
85. Carlton S, Kim S, Lekan H, Palecek J, Paleckova V, Dougherty P, Chung J, W Willis W. Anatomical changes in a primate model of experimental peripheral neuropathy (EPN). . Proc. Soc. Neurosci 18:287, 1992. e-Pub 1992.
86. Garrison CJ, Dougherty PM, Carlton SM. Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic rats treated with MK-801. . Proc. Soc. Neurosci 18:288, 1992. e-Pub 1992.
87. Willis WD, Palecek J, Paleckova V, Ragland J, Dougherty PM. Neurokinin receptor antagonists modify the responses of primate STT neurons to cutaneous stimuli. . Proc. Soc. Neurosci 18:1023, 1992. e-Pub 1992.
88. Cameron AA, Cliffer KD, Dougherty PM, Willis WD, Carlton SM. Histochemical changes in the dorsal horn of the rat following experimental peripheral neuropathy. Proc. Soc. Neurosci 17:436, 1991. e-Pub 1991.
89. Carlton SM, Dougherty PM, Pover CM, Coggeshall RE. Neuroma formation and numbers of axons in an experimental peripheral neuropathy. Proc. Soc. Neurosci 17:436, 1991. e-Pub 1991.
90. Dougherty PM, Sluka KA, Sorkin LS, Westlund KN, Willis WD. Enhancement of responses of monkey spinothalamic cells to excitatory amino acids accompanies the development of acute arthritis. Proc. Soc. Neurosci 17:1372, 1991. e-Pub 1991.
91. Palecek J, Paleckova V, Dougherty PM, Willis WD, Carlton SM. Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy. Proc. Soc. Neurosci 17:437, 1991. e-Pub 1991.
92. Garrison CJ, Dougherty PM, Willis WD, Carlton SM. Influences of local anesthetic upon experimental models of peripheral mononeuropathy. . Proc. Soc. Neurosci 17:436, 1991. e-Pub 1991.
93. Willis WD, Dougherty PM. Potentiation of responses of monkey spinothalamic (STT) cells to excitatory amino acids accompanies the development of capsaicin-induced hyperalgesia. Proc. Soc. Neurosci 17:1372, 1991. e-Pub 1991.
94. Paleckova V, Palecek J, Dougherty PM, Carlton SM, Willis WD. Responses of spinothalamic tract (STT) neurons to mechanical and thermal stimulation of skin in rats. Proc. Soc. Neurosci 17:437, 1991. e-Pub 1991.
95. Lekan HA, Dougherty PM, Carlton SM. Ultrastructural changes in the ventral horn of the rat spinal cord in experimental peripheral neuropathy. Proc. Sco. Neurosci 17:436, 1991. e-Pub 1991.
96. Cliffer KD, Cameron AA, Dougherty PM, Willis WD, Carlton SM. Histochemical changes in gracile nucleus following experimental peripheral neuropathy in the sciatic nerve of rats. Proc. Soc. Neurosci 17:436, 1991. e-Pub 1991.
97. Hayes ES, Dougherty PM, Carlton SM. An electron microscopic analysis of soybean agglutinin-labeled profiles in the rat dorsal horn following experimental peripheral neuropathy. Proc. Soc. Neurosci 17:436, 1991. e-Pub 1991.
98. Westlund KN, Sun YC, Sluka KA, Dougherty PM, Sorkin LS, Willis WD. Change in glutamate immunoreactivity in the medial articular nerve of the primate during acute experimental arthritis. Proc. Soc. Neurosci 17:1371, 1991. e-Pub 1991.
99. Sluka KA, Dougherty PM, Sorkin LS, Willis WD, Westlund KN. Substance P, calcitonin gene-related peptide and glutamate alterations in the spinal cord of the primate during acute arthritis. Proc. Soc. Neurosci 17:1372, 1991. e-Pub 1991.
100. Sorkin LS, Westlund KN, Sluka KA, Dougherty PM, Willis WD. Time course of amino acid release into the lumbar dorsal horn of the primate during development of an acute arthritis. Proc. Soc. Neurosci 17:1371, 1991. e-Pub 1991.
101. Dougherty PM, Willis WD. Enhancement of responses of primate spinothalamic (STT) cells following combined iontophoretic application of excitatory amino acids (EAA's) and substance P (SP). . Proc. Houston Soc. Engin. Med. Biol 9:27, 1990. e-Pub 1990.
102. Dougherty PM, Willis WD. Long-lasting enhancement of excitibility of spinothalamic tract neurones following combined application of excitatory amino acids and substance P in anaesthetized macaques. J. Physiol 425:38P, 1990. e-Pub 1990.
103. Willis WD, Dougherty PM. Long-lasting enhancement of responses of spinothalamic tract (STT) cells to mechanical stimulation of skin during potentiation of amino acid (EAA) responses by substance P (SP). . Proc. Soc. Neurosci 16:161, 1990. e-Pub 1990.
104. Garrison C, Dougherty PM, Carlton SM. Increases in GFAP immunostaining in lumbar spinal cord following sciatic nerve injury. Proc. Soc. Neurosci 16:1074, 1990. e-Pub 1990.
105. Dougherty PM, Willis WD. Long-lasting enhancement of responses of spinothalamic tract (STT) neurons to excitatory amino acids (EAA's) by combined iontophoretic application with substance P (SP). . Proc. Soc. Neurosci 16:161, 1990. e-Pub 1990.
106. Dafny N, Dougherty PM, Reyes-Vazquez C. The immune-derived peptide, interferon, conveys information from the immune system into the central nervous system. Proc. First Internat. Conf. Neuroimmunomod, 1990. e-Pub 1990.
107. Preston C, Dougherty PM, Dafny N. Antinociceptive and behavioral effects of stimulation in the dorsal raphe, lateral habenula, pretectal area, and ventral tegemental area. Proc. Soc. Neurosci 15:151, 1989. e-Pub 1989.
108. Dougherty PM, Owens C, Zhang D, Willis WD. Sensitization of primate spinothalamic tract neurons by electrical stimulation of sensory afferents. Proc. Soc. Neurosci 15:469, 1989. e-Pub 1989.
109. Dougherty PM, Dafny N. Microiontophoretic application of muramyl-dipeptide alters the discharge frequency of hypothalamic and hippocampal neurons. Proc. Soc. Neurosci 14:1282, 1988. e-Pub 1988.
110. Qiao JT, Wiggins RC, Dougherty PM, Dafny N. Comparison and contrast of addictive agents on CNS structures. I. Cocaine and morphine effects following microiontophoresis into caudate, nucleus accumbens, and medial prefrontal cortex. . Proc. Soc. Neurosci 14:660, 1988. e-Pub 1988.
111. Wiggins RC, Qiao JT, Dougherty PM, Dafny N. Comparison and contrast of addictive agents on CNS structures. II. Cocaine and morphine effects on habenula and the parafasciculus thalami. . Proc. Soc. Neurosci 14:660, 1988. e-Pub 1988.
112. Dafny N, Dougherty PM. Muramyl-dipeptides alter the neuronal firing rate of the hypothalamus and hippocampus but not the dorsal raphe. Proc. Soc. Neurosci 14:1282, 1988. e-Pub 1988.
113. Collard Q, Dougherty PM, Krajewski KJ, Dafny N. Neuro-immunomodulation, central opioids, and the immune response to bacterial endotoxin. Proc. Soc. Neurosci 13:1437, 1987. e-Pub 1987.
114. Lee JR, Dougherty PM, KJ Krajewski KJ, Dafny N. Neuro-immunomodulation, central opioids and the immune response to virus. Proc. Soc. Neurosci 13:919, 1987. e-Pub 1987.
115. Henderson K, Dougherty PM, Krajewski KJ, Dafny N. Immune suppression and central opioid activity. Proc. Soc. Neurosci 13:918, 1987. e-Pub 1987.
116. Dougherty PM, Dafny N. Central opioid systems are differentially affected by products of the immune response. Proc. Soc. Neurosci 13:1437, 1987. e-Pub 1987.
117. Aronowski J, Dougherty PM, Dafny N. Prenatal exposure to morphine alters the nociceptive threshold and development of tolerance to opiates in rats. Proc. Soc. Neurosci 12:1382, 1986. e-Pub 1986.
118. Harper C, Dougherty PM, Dafny N. Interactions of immunomodifying agents upon opiate-induced hypothermia: interferon prevents the development of tolerance to morphine. Proc. Soc. Neurosci 12:1383, 1986. e-Pub 1986.
119. Pearl JM, Dougherty PM, Dafny N. Morphine and methadone dependent rats exhibit different sensitivities to interferon-alpha modulation of the naloxone precipitated withdrawal syndrome. . Proc. Soc. Neurosci 12:1381, 1986. e-Pub 1986.
120. Dougherty PM, Rronowski JA, Letzly NK, Pellis NR, Dafny N. The brain and the immune system: a specifically restored immune system is essential for the manifestation of the withdrawal syndrome of opiate dependent rats. Proc. Soc. Neurosci 12:339, 1986. e-Pub 1986.
121. Dafny N, Ronowski JA, Dougherty PM. Immune modulation of nociception and electrophysiologic responses in the presence and absence of morphine. Proc. Soc. Neurosci 12:339, 1986. e-Pub 1986.
122. Dafny N, Dougherty PM Pellis NR. The effects of immunosuppression and opiates upon the visual evoked responses of cortical and subcortical structures. Proc. Soc. Neurosci 11:907, 1985. e-Pub 1985.
123. Aronowski J, Dougherty PM, Amorajski TS, Pellis NR, Dafny N. Irradiation modifies the analgesic effects of morphine. Proc. Soc. Neurosci 11:1200, 1985. e-Pub 1985.
124. Kletzly NE, Dougherty PM, Ronowski JA, Pellis NR, Dafny N. Evidence that opiate addiction involves an immune response. Proc. Soc. Neurosci 11:1201, 1985. e-Pub 1985.
125. Dougherty PM, Ronowski JA, Drath D, Dafny N. An interaction of the immune system and opiate dependence: adoptive transfer of cyclosporine's attenuating effect upon the withdrawal syndrome. . Proc. Soc. Neurosci 11:1201, 1985. e-Pub 1985.

Book Chapters

1. Ringkamp M, Dougherty PM, Raja SN. Anatomy and Physiology of Somatosensory and Pain Processing. In: Essentials of Pain Medicine and Regional Anesthesia. Fourth Edition. Elsevier, 3-10, 2018.
2. Nouri KH, Osuagwu U, Boyette-Davis J, Ringkamp M, Raja SN, Dougherty PM. The Neurochemistry of Somatosensory and Pain Processing. In: Essentials of Pain Medicine and Regional Anesthesia. Fourth Edition. Elsevier, 11-20, 2018.
3. Dougherty PM. Neuroimmune (and other) mechanisms of chemotherapy induced neuropathy. In: PNIRS Primer, 325-332, 2016.
4. Zhang H, Cata JP, Dougherty PM. CIPN: Bedside to Bench. In: Chemotherapy-Induced Neuropathic Pain. CRC Press, pp. 137-146, 2012.
5. Boyette-Davis J, Raja SN, Hoot MR, Dougherty PM. The Neurochemistry of Somatosensory and Pain Processing. In: Essentials of Pain Medicine and Regional Anesthesia, Second Edition 2010. Second. Elsevier, pp. 1-6, 2012.
6. Boyette-Davis J, Dougherty PM. Mechanisms of Pain in Thoracic Surgery. In: Thoracic Anesthesia: Ready to Practice 2010. McGraw-Hill, pp. 102-115, 2012.
7. Raja SN, Dougherty PM. Anatomy and Physiology of Somatosensory and Pain Processing. In: Essentials of Pain Medicine and Regional Anesthesia, Third Edition 2010. Third Edition. Elsvier, pp. 1-6, 2012.
8. Fisch M, Cleeland CS, Dunn AJ. Cancer Symptom Mechanisms and Models: Neurophysiology of Pain. In: Cancer Symptom Science. Cambridge University Press, pp. 41-50, 2011.
9. Cata JP, Dougherty PM. Preclinical Studies of Intrathecal Analgesics. In: Translational Pain Research. Nova Science Publisher, 335-382, 2006.
10. Cata JP, Weng HR, Dougherty PM. Basic Neurobiology of Cancer Pain. In: Practicle Aspects of Cancer Pain Management. McGraw Hill Publishers, 57-72, 2006.
11. Dougherty PM. Pathophysiology of Cancer Pain. In: Perioperative Cancer Medicine: Anesthesia, Critical Care and Pain Control in Cancer Patients. Marcel Dekker, Inc, 1007-1029, 2005.
12. Dougherty PM, Raja SN. Neurochemistry of Somatosensory and Pain Processing. In: Essentials of Pain Medicine and Regional Anesthesia. Elsevier, 7-14, 2005.
13. Lenz FA, Greenspan JD, Dougherty PM. Central Processing of Pain and Mechanisms of Central Pain Syndrome. In: Diseases of the Nervous System. Cambridge University Press, 888-905, 2002.
14. Dougherty PM, Lee JI, Dimitriou TD, Lenz FA. Medial Thalamotomy. In: Surgical Management of Pain. George Thieme Medical Publishers, 795-802, 2001.
15. Staats PS, Dougherty PM. Spinal Analgesics: Present and Future. In: Practical Management of Pain. CV Mosby, 513-522, 2000.
16. Weng HR, Dougherty PM. Receptive Field Properties and Spike-Burst Responses to Intracellular Current Injection in Dorsal Horn Neurons. In: Proceedings of the 9th World Congress on Pain. IASP Press, 325-333, 2000.
17. Ralston DD, Dougherty PM, Lenz FA, Weng HR, Vierck CJ, Ralston HJ. Plasticity of the Inhibitory Circuitry and Neuronal Responses in the Primate Somatosensory Thalamus (VB) Following Lesions of the Dorsal Column and Spinothalamic Pathways. In: Proceedings of the 9th World Congress on Pain. IASP Press, 427-434, 2000.
18. Dougherty PM, Raja SN. Pain and the Neurochemistry of Somatosensory Processing. In: Essentials of Pain Medicine and Regional Anesthesia. Saunders, 7-9, 1999.
19. Raja SN, Dougherty PM. Pain and the Neurophysiology of Somatosensory Processing. In: Essentials of Pain Medicine and Regional Anesthesia. Saunders, 2-6, 1999.
20. Lenz FA, Dougherty PM. Pain Processing in the Human Thalamus. In: The Human Thalamus. Elsevier, 617-651, 1997.
21. Mandir AS, Rowland LH, Dougherty PM, Lenz FA. Stereotactic recording and stimulation techniques during thalamotomy and pallidotomy. In: The Basal Ganglia and New Surgical Approaches for Parkinson's Disease, Adv. Neurol. 74. Lippincott-Raven Publishers, 159-165, 1997.
22. Meyer RA, Dougherty PM. The Physiology of Pain. In: Neurosurgical Management of Pain. Springer-Verlag, 3-21, 1997.
23. Rowland LH, Dougherty PM, Lenz FA. Microelectrode recording: a brief history and review of applications for the neurosurgeon. In: Textbook of Stereotactic and Functional Neurosurgery. McGraw-Hill, 1996.
24. Lenz FA, Dougherty PM. Pain Processing in the Ventrocaudal nucelus of human thalamus. In: Pain and the Brain: From Nociception to Cognition, Advances in Pain Research and Therapy. Raven Press, 175-186, 1994.
25. Dougherty PM, Lenz FA. Plasticity of the Somatosensory System Following Neural Injury. In: Touch, temperature and pain in health and disease. Mechanisms and Assessments, Progress in Pain Research and Management. IASP Publications, 439-460, 1994.
26. Dougherty PM, Reyes-Vazquez C, Dafny ND. Immune cytokines and CNS opiate function: a possible interface for stress-induced immune suppression? . In: Stress and Immunity. Telford Press, 210-217, 1990.
27. Dafny N, Dougherty PM, Drath D. Immunosuppressive agents modulate the severity of opiate withdrawal. In: NIDA Research Monograph, Problems in Drug Dependence 1990, Proceedings of the 52nd Annual Scientific Meetings. US Dep. Health Pub, 183-191, 1990.
28. Dougherty PM, Qiao JT, Wiggins RC, Dafny N. Cocaine interaction with sulpiride,methysergide, naloxone, and desiprimine: neurophysiological effects on mesolimbic and neostriatal neuronal activity. In: NIDA Research Monograph, Problems in Drug Dependence, 1990, Proceedings of the 52nd Annual Scientific Meetings. US Dep. Health Pub, 322-331, 1990.
29. Dafny N, Dougherty PM, Pellis NR. The immune system and morphine dependence. In: NIDA Research Monograph, Problems in Drug Dependence 1989, Proceedings of the 51st Annual Scientific Meetings. US Dep. Health Pub, 293-295, 1989.
30. Zhang H, Dougherty PM. Cancer Symtom Mechanisms and Models: Neurophysiology of Pain. In: Cancer Symptom Science 2010.
31. Dougherty PM. Mechanisms of Neuropathic Pain. In: Proceedings of the 14th World Congress on Pain. IASP Press.
32. Cata JP, Zhang H, Driver LC, Hamid B, Biralt S, Burton AW, Dougherty PM. Mechanisms of Chemotherapy-Induced Neuropathic Pain. In: Cancer Pain: Research from Molecules to Suffering 2010. IASP.