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Paul J. Chiao, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Surgical Oncology - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston
Professor, U of Texas Graduate School of Biomedical Sciences, Houston, TX

Office Address

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 108
Houston, TX 77030
Room Number: Y8.6085, Laboratory Y8.6041 - Y8.6049

Education & Training

Degree-Granting Education

1991 University of Texas Health Science Center, Houston, TX, PHD, Cancer Biology
1984 The University of Iowa, Iowa City, IA, BS, Microbiology

Postgraduate Training

1991-1995 Postdoctoral Fellow, Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, Dr. Inder M. Verma

Honors and Awards

2011-2016 Ashbel Smith Professorship Award, The University of Texas M. D. Anderson Cancer Center
1997 Excellent Young Scientist of 1997, The Foundation of Dr. Wang, Q. C. of the Chinese Academy of Science
1991-1994 National Institutes of Health Postdoctoral Fellowship Award, NIH
1986-1991 American Legion Auxiliary Fellowship for Predoctoral Research Award, Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas
1981-1982 Undergraduate Scholarship, University of Iowa

Selected Publications

Peer-Reviewed Original Research Articles

1. Peng B, Lee, AJ, Wang Z, Ling J, Jin W, Yang K, Zhang R, Chang Z, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's Syndrome in the mice with mutated kappaB enhancers of the lkappaBalpha promoter. Proc Natl Acad Sci USA 107(34):15193-15198, 8/2010. PMID: 20696914.
2. Melisi D, Xia Q, Paradiso G, Ling J, Moccia T, Carbone C, Budillon A, Abbruzzese JL, Chiao PJ. Modulation of pancreatic cancer chemoresistance by inhibition of TAK1. J Natl Cancer Inst 103(15):1190-204, 8/2011. e-Pub 7/2011. PMCID: PMC3149044.

Grant & Contract Support

Title: TAK1 is a novel therapeutic target in pancreatic cancer
Funding Source: Pancreatic Cancer Action Network-AACR
Role: Principal Investigator
Duration: 7/26/2012 - 7/25/2014
 
Title: A SYSTEMATIC RNA INTERFERENCE STRATEGY FOR IDENTIFYING KINASES AS SYNTHETIC LETHAL PARTNERS TO TARGET ONCOGENIC KRAS/TAK1 SIGNALING AXIS IN PANCREATIC CANCER
Funding Source: Viragh Foundation
Role: Principal Investigator
Duration: 6/7/2012 - 5/31/2017
 
Title: Mechanisms of overexpressed TrkB in inducing pancreatic cancer metastasis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2010 - 6/30/2015
 
Title: Function and Regulation Mechanisms of Polo-like Kinase 3 in Pancreatic Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2010 - 3/31/2015
 
Title: Mechanism of constitutive RelA activation in Pancreas Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2009 - 6/30/2014
 
Title: Validation of potential early diagnostic and prognostic markers for pancreatic cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 2006 - 2008
 
Title: The mechanisms of tumorigenesis of pancreatic epithelial cells
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 10/1/2005 - 9/30/2010
 
Title: NF-kappaB signaling pathways in pancreatic cancer biology and therapy
Funding Source: NIH/NCI
Role: Project Leader
Duration: 9/1/2003 - 8/31/2008
 
Title: Mechanism of constitutive RelA activation in Pancreas Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2003 - 8/31/2007
 
Title: The function of NF-kappaB in Cancer Metastasis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 2000 - 2002
 
Title: Restoration of apoptosis in cancer
Funding Source: NIH/NCI
Role: Project Leader
Principal Investigator: Jack Roth
Duration: 7/1999 - 2004
 
Title: The role of RelA in human adenocarcinoma of pancreas
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 1/1998 - 12/2003
 
Title: The function and clinical significance of DPC4 tumor suppressor gene in cancer
Funding Source: ATP/ARP
Role: Principal Investigator
Duration: 1/1/1998 - 12/1/2000
 
Title: The function and clinical significance of DPC4 tumor suppressor gene in cancer
Funding Source: Texas Higher Education Orrdinating Board Advanced Technology Program (ATP/ARP)
Role: Principal Investigator
Duration: 1/1998 - 12/2000
 
Title: Global Profiling of Ubiquitination in the NF-kappaB Pathway for Pancreatic Cancer
Funding Source: NIH/NCI
Role: Co-Principal Investigator
 
Title: Regulation of MAP kinase signaling in carcer progression and metastasis
Funding Source: NIH/NCI
Role: Principal Investigator
 
Title: Transgenic/knockout mouse model for pancreatic cancer
Funding Source: NIH/NCI
Role: Principal Investigator-MDACC

Last updated: 7/2/2014