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Paul G. Corn, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor of Medicine, Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1993 Georgetown University, Washington, DC, MD, Medicine
1993 Georgetown University, Washington, DC, PHD, Microbiology
1985 Columbia University, New York, NY, BA, Sociology

Postgraduate Training

7/1996-6/2000 Fellowship Medical Oncology, Johns Hopkins Oncology, Baltimore, MD
7/1994-6/1996 Resident in Medicine, University of Chicago Hospital, Chicago, IL
7/1993-6/1994 Intern in Medicine, University of Chicago Hospital, Chicago, IL

Board Certifications

1/1998 American Board of Internal Medicine
1/1996 American Board of Internal Medicine

Experience/Service

Academic Appointments

Instructor, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 7/2000-9/2004

Administrative Appointments/Responsibilities

Medical Oncology Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA, 1/2002-9/2004
Medical Oncology Attending Physician, Veterans Administration Hospital, Philadelphia, PA, 1/2002-1/2004

Honors and Awards

1994 Housestaff Recognition Award, University of Chicago, Department of Medicine
1993 Alpha Omega Alpha
1993 Mario Mollari Award, Award for Outstanding Performance in the Department of Microbiology, Georgetown University Medical School
1993 The Gregory M. Chirikjian Award, Georgetown University Medical School
1991 Georgetown University, 2nd Place, Medical Research Day, Pre-doctoral Division
1990 Bioethics Essay Award, Washington Academy of Medicine
1989 Student Research Award, American Society of Microbiology

Selected Publications

Peer-Reviewed Original Research Articles
1. Jonasch E, Tannir N, Corn P, Warneke CL, Johnson M, Tamboli P, Ng C, Aparicio A, Ashe RG, Jonasch WD, Wright J. Upfront randomized phase II trial of sorafenib versus sorafenib and low-dose interferon alpha in patients with advanced renal cell carcinoma. Cancer. In Press.
2. Jonasch E, Wood C, Matin S, Tu SM, Pagliaro L, Corn P, Aparicio A, Tamboli P, Millikan R, Wang X, Araujo C. Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma. J Clin Oncol. e-Pub 7/2009. PMID: 19636008.
3. Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn P. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther. e-Pub 3/2009. PMID: 19106640.
4. Tsao CC, Teh BT, Johasch E, Shreiber-Agus, Efstathiou E, Hoang A, Czerniak B, Logothetis, Corn PG. Inhibition of Mxi1 suppresses HIF-2alpha-dependent renal cancer tumorigenesis. Cancer Biol Ther 7(10):1619-27, 10/2008. e-Pub 10/2008. PMID: 19018165.
5. Kojima K, Shimanuki M, Shikami M, Samudio IJ, Ruvulo V, Corn P, Hanoaka N, Konopleva M, Andreef M, Nakakuma H. The dual P13 kinase/mTOR inhibotor P1-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML. Leukemia 22(9):1728-36, 9/2008. e-Pub 6/2008. PMID: 18548093.
6. Corn PG. Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma:defining the pancreatic cancer epigenome. Cancer Biol Ther 7(7):1157-9, 7/2008. e-Pub 7/2008. PMID: 18698160.
7. Gardner LB, Corn PG. Hypoxic regulation of mRNA expression. Cell Cycle 7(13):1916-24, 7/2008. e-Pub 4/2008. PMID: 18604161.
8. Corn PG. Hypoxic regulation of miR-210: Shrinking targets expand HIF-1's influence. Cancer Biol Ther 7(2):265-7, 2/2008. e-Pub 2/2008. PMID: 18347426.
9. Corn PG, El-Deiry WS. Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage. Cancer Biol Ther 6(12):1858-66, 12/2007. e-Pub 11/2007. PMID: 18087215.
10. Corn PG. Role of the Ubiquitin-proteasome system in Renal Cell Carcinoma. BMC Biochem 8 Suppl(1:S4):S4, 11/2007. PMCID: PMC2106368.
11. Corn PG. Reactivation of p53 function with a demethylating agent. Cancer Biol Ther 5(9):1161-2, 9/2006. PMID: 17012838.
12. Corn PG, Ricci MS, Scata KA, Arsham AM, Simon MC, Dicker DT, El-Deiry WS. Mx1 is Induced by Hyposia in a HIF-1 Dependent manner and Protects Cells from c-Myc-Induced Apoptosis. Cancer Biol Ther 4(11):1285-94, 11/2005. e-Pub 11/2005. PMID: 16319523.
13. Corn PG, Rikhof B, El-Deiry WS. Caspase 10 levels are increased following DNA damage in a p53-dependent manner. Cancer Biol Ther 2(6):707-12, Nov-Dec, 12/2003. PMID: 14688482.
14. Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS. Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis 24(1):47-51, 12/2003. PMID: 12538348.
15. Corn PG, McDonald ER, 3rd, Herman JG, El-Deiry WS. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat Genet 3(3):229-37, 11/2003. e-Pub 10/2003. PMID: 14556007.
16. Corn PG, El-Deiry WS. Derangement of growth and differentiation control in oncogenesis. Bioessays 24(1):83-90, 1/2002. PMID: 11782953.
17. Corn PG, Heath EI, Heitmiller R, Fogt F, Forastiere AA, Herman JG, Wu TT. Frequent hypermethylation of the 5' CpG island of E-cadherin in esophageal adenocarcinoma. Clin Cancer Res 7(9):2765-9, 9/2001. PMID: 11555590.
18. Nicholson SA, Okby NT, Khan MA, Welsh JA, McMenamin MG, Travis WD, Jett JR, Tazelaar HD, Trastek V, Pairolero PC, Corn PG, Herman JG, Liotta LA, Caporaso NE, Harris CC. Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma. Cancer Res 61(14):5636-43, 7/2001. PMID: 11454718.
19. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 61(8):3225-9, 4/2001. PMID: 11309270.
20. Esteller M, Cordon-Cardo C, Corn PG, Meltzer SJ, Pohar KS, Watkins DN, Capella G, Peinado MA, Matias-Guiu X, Prat J, Baylin SB, Herman JG. p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. Cancer Res 61(7):2816-21, 4/2001. PMID: 11306450.
21. Corn PG, Smith BD, Ruckdeschel ES, Douglas D, Baylin SB, Herman JG. E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia. Clin Cancer Res 6(11):4243-8, 11/2000. PMID: 11106238.
22. Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene 19(1):164-8, 1/2000. PMID: 10644993.
23. Corn PG, Kuerbitz SJ, van Noesel MM, Esteller M, Compitello N, Baylin SB, Herman JG. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. Cancer Res 59(14):3352-6, 7/1999. PMID: 10416592.
24. Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res 59(4):798-802, 2/1999. PMID: 10029065.
25. Esteller M, Corn PG, Urena JM, Gabrielson E, Baylin SB, Herman JG. Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia. Cancer Res 58(20):4515-8, 10/1998. PMID: 9788592.
26. Corn PG, Anders J, Takala AK, Kayhty H, Hoiseth SK. Genes involved in haemophilus influenzae type b capsule expression are frequently amplified. J. Infec. Dis. 167(2):356-64, 2/1993. PMID: 8421169.

Abstracts
1. Tsao CC, Corn PG. Nutlin-3a induces growth arrest in kidney cancer cell lines in a p53-dependent manner. AACR - 100th Annual Meeting, 2009.
2. Jonasch E, Corn P, Ashe RG, Do K, Tannir NM. Randomized phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma. ASCO Proceedings - 2007 5104, 2007.
3. Tsavachidou D, Tannir NM, Wood CG, Corn P, Do K, Tamboli P, Smith LA, Matin S, Jonasch E. Von Hippel-Lindau gene mutation stuatus is associated with a dichotomous response in primary and metastatic tumors in patients receiving bevacizumab and erlotinib for metastatic renal cell carcinoma. ASCO Proceedings - 2007 15522, 2007.

Book Chapters
1. Corn PG. The basics of Human Cancer Genetics. In: Cancer Biology and Therapeutics. 2, 119, 2003.

Grant & Contract Support

Title: Development of Novel Therapies in Prostate Cancer
Funding Source: Inveco International Inc.
Role: Principal Investigator
Duration: 2/1/2006 - 12/31/2007
 
Title: Tumor Hypoxia in Prostate Cancer Progression
Funding Source: Prostate Cancer Foundation (PCF)
Role: Principal Investigator
Duration: 11/1/2005 - 11/1/2008
 
Title: Tumor Hypoxia in Prostate Cancer Progression
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/22/2005 - 12/31/2007
 
Title: Regulation of the von Hippel-Lindau Protein
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/9/2003 - 8/31/2009

Last updated: 9/24/2009