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Prajnan Das, M.D., M.S., M.P.H.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2003 Harvard School of Public Health, Boston, MA, MPH, Clinical Effectiveness
1999 Harvard Medical School, Boston, MA, MD, cum laude, Medicine
1995 Stanford University, Stanford, CA, BS, Honors and Distinction, Biological Sciences
1995 Stanford University, Stanford, CA, MS, Biological Sciences

Postgraduate Training

7/2000-6/2004 Clinical Residency, Radiation Oncology, Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA
6/1999-6/2000 Clinical Internship, Internal Medicine, Brigham and Women's Hospital, Boston, MA

Board Certifications

2005 American Board of Radiology, Radiation Oncology

Experience/Service

Administrative Appointments/Responsibilities

Director of Quality Assurance, Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 8/2008-present
Director, Medical Student Education Program, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 7/2007-present

Honors and Awards

2008 Luis Delclos Award for Excellence in Teaching, Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center
1999 cum laude, Harvard Medical School
1995 Honors and Distinction, Stanford University
1994 Phi Beta Kappa, Stanford University

Selected Publications

Peer-Reviewed Original Research Articles
1. Chang GJ, Gonzalez RJ, Skibber JM, Eng C, Das P, Rodriguez-Bigas MA. A Twenty-year Experience with Adenocarcinoma of the Anal Canal. Dis Colon Rectum. In Press.
2. Das P, Delclos ME, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Eng C, Bedi M, Krishnan S, Crane CH. Hyperfractionated Accelerated Radiotherapy for Rectal Cancer in Patients with Prior Pelvic Irradiation. Int J Radiat Oncol Biol Phys. In Press.
3. Das P, Cantor SB, Parker CL, Zampieri JB, Baschnagel A, Eng C, Delclos ME, Krishnan S, Janjan NA, Crane CH. Long-Term Quality of Life after Radiation Therapy for Treatment of Anal Cancer. Cancer. In Press.
4. Ajani JA, Wang X, Izzo JG, Crane CH, Eng C, Skibber JM, Das P, Rashid A. Molecular Biomarkers Correlate with Disease-Free Survival in Patients with Anal Canal Carcinoma Treated with Chemoradiation. Dig Dis Sci. e-Pub 4/2009. PMID: 19399614.
5. Hodges JC, Das P, Eng C, Reish AG, Beddar AS, Delclos ME, Krishnan S, Crane CH. Intensity-Modulated Radiation Therapy for the Treatment of Squamous Cell Anal Cancer with Para-Aortic Nodal Involvement. Int J Radiat Oncol Biol Phys, 2009. e-Pub 2/2009. PMID: 19231109.
6. Crane CH, Eng C, Feig BW, Das P, Skibber JM, Chang GJ, Wolff RA, Krishnan S, Hamilton S, Janjan NA, Maru DM, Ellis LM, Rodriguez-Bigas MA. Phase II Trial of Neoadjuvant Bevacizumab, Capecitabine, and Radiotherapy for Locally Advanced Rectal Cancer. Int J Radiat Oncol Biol Phys. e-Pub 2009.
7. Herman MP, Kopetz S, Bhosale PR, Eng C, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Delclos ME, Krishnan S, Crane CH, Das P. Sacral Insufficiency Fractures After Preoperative Chemoradiation for Rectal Cancer: Incidence, Risk Factors, and Clinical Course. Int J Radiat Oncol Biol Phys 74:818-823, 2009. PMID: 19147305.
8. Park HC, Janjan NA, Mendoza TR, Lin EH, Vadhan-Raj S, Hundal M, Zhang Y, Delclos ME, Crane CH, Das P, Wang XS, Cleeland CS, Krishnan S. Temporal Patterns of Fatigue Predict Pathologic Response in Patients Treated with Preoperative Chemoradiation Therapy for Rectal Cancer. Int J Radiat Oncol Biol Phys, 2009. e-Pub 2/2009. PMID: 19231100.
9. Das P, Ng A, Constine LS, Hodgson DC, Mendenhall NP, Morris DE, Yunes MJ, Chauvenet AR, Hudson MM, Winter JN. ACR Appropriateness Criteria on Hodgkin's lymphoma - Favorable prognosis stage I and II. J Am Coll Radiol 5:1054-1066, 2008.
10. Kim MM, Mansfield PF, Das P, Janjan NA, Badgwell BD, Phan AT, Delclos ME, Maru D, Ajani JA, Crane CH, Krishnan S. Chemoradiation therapy for potentially resectable gastric cancer: clinical outcomes among patients who do not undergo planned surgery. Int J Radiat Oncol Biol Phys 71(1):167-172, 2008. PMID: 18406886.
11. Kim MM, Rana V, Janjan NA, Das P, Phan AT, Delclos ME, Mansfield PF, Ajani JA, Crane CH, Krishnan S. Clinical benefit of palliative radiation therapy in advanced gastric cancer. Acta Oncol 47(3):421-427, 2008. e-Pub 2007. PMID: 17899453.
12. Myerson RJ, Garofalo MC, Naga IE, Abrams RA, Apte A, Bosch WR, Das P, Gunderson LL, Hong TS, Kim JJ, Willett CG, Kachnic LA. Elective clinical target volumes for conformal therapy in anorectal cancer: An Radiation Therapy Oncology Group Consensus Panel Contouring Atlas. Int J Radiat Oncol Biol Phys 74:824-830, 2008.
13. Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthery JN. Extrahepatic bile duct adenocarcinoma: Patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone. Ann Surg Oncol 15(11):3147-3156, 2008. e-Pub 8/2008. PMID: 18754070.
14. Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, Pisters PW, Ajani JA, Crane CH. Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys 71(3):741-747, 2008. e-Pub 2007. PMID: 18164837.
15. Yu T-K, Bhosale PR, Crane CH, Iyer RB, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Das P. Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys 71(4):1175-1180, 2008. e-Pub 1/2008. PMID: 18207667.
16. Varadhachary GR, Wolff RA, Crane CH, Sun CC, Lee J, Pisters PW, Vauthey JN, Abdalla E, Wang H, Staerkel GA, Lee JH, Ross WA, Tamm EP, Bhosale PR, Krishnan S, Das P, Ho L, Xiong H, Abbruzzese JL, Evans DB. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 26(21):3487-3495, 2008. PMID: 18640929.
17. Das P, Crane CH, Eng C, Ajani JA. Prognostic factors for squamous cell cancer of the anal canal. Gastrointest Cancer Res 2(1):1-14, 2008. PMID: 19259318.
18. Krishnan S, Rana V, Evans DB, Varadhachary G, Das P, Bhatia S, Delclos ME, Janjan NA, Wolff RA, Crane CH, Pisters PW. Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of Vater. Int J Radiat Oncol Biol Phys 70(3):735-743, 2008. e-Pub 2008. PMID: 17980502.
19. Bedi M, Das P, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Eng C, Wolff RA, Janjan NA, Krishnan S, Crane CH. Capecitabine and timing of radiotherapy during preoperative chemoradiation for rectal cancer. Gastrointest Cancer Res 1:44-48, 2007.
20. Krishnan S, Rana V, Janjan NA, Varadhachary GR, Abbruzzese JL, Das P, Delclos ME, Gould MS, Evans DB, Wolff RA, Crane CH. Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy. Cancer 110:47-55, 2007.
21. Das P, Bhatia S, Eng C, Ajani JA, Skibber JM, Rodriguez-Biagas MA, Chang GJ, Bhosale P, Delclos ME, Krishnan S, Janjan NA, Crane CH. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Biol Phys 68:794-800, 2007.
22. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Wolff RA, Eng C, Krishnan S, Janjan NA, Crane CH. Predictors of tumor response and downstaging in patients treated with preoperative chemoradation for rectal cancer. Cancer 109:1750-1755, 2007.
23. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Levy LB, Ellis LM, Crane CH. Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol 29:219-224, 2006. PMID: 16755173.
24. Das P, Fukami N, Ajani JA. Combined modality therapy of localized gastric and esophageal cancers. J Natl Compr Canc Netw 4:375-382, 2006. PMID: 16569390.
25. Das P, Ng AK, Earle CC, Mauch PM, Kuntz KM. Computed tomography screening for lung cancer in Hodgkin's lymphoma survivors: decision analysis and cost-effectiveness analysis. Ann Oncol 17:785-793, 2006. PMID: 16500905.
26. Das P, Wolff RA, Abbruzzese JL, Varadhachary GR, Evans DB, Vauthey JN, Baschnagel A, Delclos ME, Krishnan S, Janjan NA, Crane CH. Concurrent capecitabine and upper abdominal radiation therapy is well tolerated. Radiat Oncol 1:41, 2006. PMID: 17062148.
27. Krishnan S, Lin EH, Gunn GB, Chandra A, Beddar AS, Briere TM, Das P, Delclos ME, Janjan NA, Crane CH. Conformal radiotherapy of the dominant liver metastasis: a viable strategy for treatment of unresectable chemotherapy refractory colorectal cancer liver metastases. Am J Clin Oncol 29:562-567, 2006. PMID: 17148992.
28. Krishnan S, Janjan NA, Skibber JM, Rodriguez-Bigas MA, Wolff RA, Das P, Delclos ME, Chang GJ, Hoff PM, Eng C, Brown TD, Crane CH, Feig BW, Morris J, Vadhan-Raj S, Hamilton SR, Lin EH. Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 66:762-771, 2006. PMID: 17011451.
29. Das P, Lin EH, Bhatia S, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Delclos ME, Krishnan S, Janjan NA, Crane CH. Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysis. Int J Radiat Oncol Biol Phys 66:1378-1383, 2006. PMID: 17056196.
30. Krishnan S, Rana V, Janjan NA, Abbruzzese JL, Gould MS, Das P, Delclos ME, Palla S, Guha S, Varadhachary G, Evans DB, Wolff RA, Crane CH. Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation. Cancer 107:2589-2596, 2006. PMID: 17083124.
31. Beddar AS, Krishnan S, Briere TM, Wang X, Delclos ME, Ballo MT, Das P, Gould S, Horton JL, Crane CH. The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. Radiother Oncol 78:207-212, 2006. PMID: 16376445.
32. Das P, Ng AK, Stevenson MA, Mauch PM. Clinical course of thoracic cancers in Hodgkin's disease survivors. Ann Oncol 16:793-797, 2005. PMID: 15802277.
33. Das P, Ajani JA. Gastric and gastro-oesophageal cancer therapy. Expert Opin Pharmacother 6:2805-2812, 2005. PMID: 16318431.
34. Das P, Kaplan I. The role of PC-SPES, selenium, and vitamin E in prostate cancer. Oncology (Williston Park) 16:285-291; discussion 291, 295-296, 299-300, 2002. PMID: 15046388.
35. Das P, Chen MH, Valentine K, Lopes L, Cormack RA, Renshaw AA, Tempany CM, Kumar S, D'Amico AV. Using the magnitude of PSA bounce after MRI-guided prostate brachytherapy to distinguish recurrence, benign precipitating factors, and idiopathic bounce. Int J Radiat Oncol Biol Phys 54:698-702, 2002. PMID: 12377320.

Invited Articles
1. Das P, Crane CH. Staging, Prognostic Factors and Therapy of Localized Rectal Cancer. Curr Oncol Rep 11(3):167-174, 2009. PMID: 19336008.
2. Das P. Preoperative Chemoradiotherapy for Stage III Rectal Cancer. Gastrointest Cancer Res 2(6):302-304, 11/2008. PMID: 19259282.
3. Das P, Crane CH, Ajani JA. Current treatment for localized anal carcinoma. Curr Opin Oncol 19:396-400, 2007.
4. Crane CH, Das P. Potential benefits of integration of targeted therapies with chemoradiation in rectal cancer. Gastrointest Cancer Res 1:S77-S84, 2007.
5. Das P, Crane CH. Preoperative and adjuvant treatment of localized rectal cancer. Curr Oncol Rep 8:167-173, 2006. PMID: 16618380.

Book Chapters
1. Das P, Ludwig M, Janjan NA, Crane CH. The Anal Region. In: Radiation Oncology, 9th. Ed(s) JD Cox, KK Ang. Elsevier: Philadelphia, 2009.
2. Janjan NA, Delclos ME, Crane CH, Krishnan S, Das P. The Colon and Rectum. In: Radiation Oncology, 9th. Ed(s) JD Cox, KK Ang. Elsevier: Philadelphia, 2009.
3. Krishnan S, Das P, Crane CH. The Liver and Biliary System. In: Radiation Oncology, 9th. Ed(s) JD Cox, KK Ang. Elsevier: Philadelphia, 2009.
4. Das P, Rodriguez-Bigas MA, Hoff PM, Crane CH. Neoadjuvant and adjuvant therapy for rectal adenocarcinoma. In: Advanced Therapy in Surgical Oncology. Ed(s) Pollock RE, Curley SA, Ross MI, Perrier NE. BC Decker: Hamilton, Ontario, 308-315, 2008.
5. Janjan N, Mahajan A, Chang EL, McCutcheon I, Lin E, Das P, Krishnan S, Chow E. Prognosis in Spinal Cord Compression. In: Prognosis in Advanced Cancer. Ed(s) Glare P, Christakis NA. Oxford University Press, 329-344, 2008.
6. Janjan N, Krishnan S, Das P, Gould MS, Zampieri J, Crane C, Delclos M, Cleeland C, Lutz ST, Chow E. Palliative Radiation Therapy Techniques. In: Cancer Pain Management. Ed(s) MJ Fisch, AW Burton. McGraw Hill, 271-293, 2007.

Last updated: 8/26/2009