Pratip K. Bhattacharya, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
About Dr. Bhattacharya
The focus of research in Dr. Bhattacharya's laboratory in the Department of Cancer Systems Imaging is the development of real-time metabolic and imaging applications by hyperpolarization. We are exploring novel ways to utilize Magnetic Resonance Imaging (MRI) to create more detailed metabolic and molecular imaging studies by employing hyperpolarized, non-radioactive carbon 13 (13C) and nitrogen 15 (15N)-labeled compounds and silicon particles and nanoparticles (SiNPs) to tag specific metabolic and biochemical structures and functions that are altered in cancer. Hyperpolarized MR is a non-toxic, non-radioactive method for non-invasively assessing tissue metabolism and other physiologic properties. Hyperpolarization allows for a >10,000-fold signal enhancement relative to conventional MRI or MRS. After hyperpolarization, the signal enhancement can be retained on the metabolites of the hyperpolarized molecules for several minutes. Dr. Bhattacharya’s, lab is working on techniques to extend this relaxation time so that more detailed metabolic and molecular imaging studies can be considered.
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Magnetic Resonance laboratory is involved in three primary areas of research:
· Real time metabolic MR imaging with hyperpolarized 13C and 15N labeled non-radioactive compounds. The goal of this research is to use mostly endogenous compounds to track different metabolic pathways in vivo in real time both in preclinical animal models and in human applications.
· Real-time molecular MR imaging with hyperpolarized silicon nanoparticle (SiNPs) functionalized to target specific biological functions and structure. Hyperpolarized SiNPs have opened the door for targeted functional imaging by MR that used to be in the realm of PET and SPECT. Due to the simple surface chemistry, the hyperpolarized SiNPs can serve as a nanoplatform, allowing a variety of targeting agents and potentially therapeutic drugs to be loaded onto the particles, which enables real-time targeted Theranostics imaging studies with an imaging time window of roughly one hour.
· High resolution MR metabolomics of animal and human tissues. To complement the real-time in vivo hyperpolarization studies, we have developed an MR based metabolomics program to generate comprehensive metabolic profiles of cancerous and non-cancerous tissues in vitro.
Present Title & Affiliation
Primary Appointment
Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Graduate Faculty, Department of Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX
Associate Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Hyperpolarization: liquid and solid state, Real-time molecular and metabolic imaging in vivo, Silicon nanoparticle hyperpolarization for targeted MRI and nanochemistry, Parahydrogen Induced Polarization and Dynamic Nuclear Polarization
Education & Training
Degree-Granting Education
| 2005 | California Institute of Technology, Pasadena, California, US, Chemistry, Prof. Jacqueline K. Barton, Ph.D |
Postgraduate Training
| 2005-2006 | James G. Boswell Fellowship, MR Physics, Huntington Medical Research Institutes/Caltech, Pasadena, California |
Experience & Service
Other Professional Positions
James G. Boswell Fellow, California Institute of Technology & MR Unit, Huntington Medical Research Institutes, Pasadena, CA, 2004 - 2006
Graduate Research Assistant, California Institute of Technology, Pasadena, CA, 2000 - 2004
Extramural Institutional Committee Activities
Committee Member, Department of Veterinary Medicine, The University of Texas MD Anderson Cancer Center, 2019
Committee Member, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 2018
Member, Center for Advanced Biomedical Imaging (CABI) MR Operations Committee, The University of Texas MD Anderson Cancer Center, 2017 - Present
Co-Chair, Cancer Metabolism Working Group, The University of Texas MD Anderson Cancer Center, 2017 - Present
Committee Member, SPINlab Steering Committee, The University of Texas MD Anderson Cancer Center, 2016 - Present
Committee Member, Diagnostic Imaging Strategic Plan Functional Committee, The University of Texas MD Anderson Cancer Center, 2016 - Present
Representative, Keck Executive Committee for Gulf Coast Consortia, The University of Texas MD Anderson Cancer Center, 2016 - Present
Committee Member, Postdoctoral Advisory Committee, The University of Texas MD Anderson Cancer Center, 2015 - Present
Committee Member, Institutional Research Grant (IRG Clinical) Committee, The University of Texas MD Anderson Cancer Center, 2015 - Present
Committee Member, CCSG NMR Shared Resource Facility Steering Committee, The University of Texas MD Anderson Cancer Center, 2015 - Present
Committee Member, Diagnostic Imaging Educational Functional Committee, The University of Texas MD Anderson Cancer Center, 2014 - Present
Co-Champion, Diagnostic Imaging Research Strategic Planning Committee, The University of Texas MD Anderson Cancer Center, 2014 - Present
Committee Member, MD Anderson Faculty Health Advisory Committee, The University of Texas MD Anderson Cancer Center, 2013 - 2016
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Hsieh KL, Zhang K, Chu Y, Yu L, Li X, Hu N, Kawosa I, Pilie PG, Bhattacharya PK, Zhi D, Jiang X, Zhao Z, Dai Y. iGTP: learning interpretable cellular embedding for inferring biological mechanisms underlying single-cell transcriptomics. Brief Bioinform 26(3), 2025. e-Pub 2025. PMID: 40551620.
- Ma X, Hsu YC, Asare A, Zhang K, Glassman D, Handley KF, Foster K, Sharma K, Westin S, Jazaeri A, Fleming ND, Bhattacharya PK, Jiang X, Sood AK, Shams S. A pioneering artificial intelligence tool to predict treatment outcomes in ovarian cancer via diagnostic laparoscopy. Sci Rep 15(1):14437, 2025. e-Pub 2025. PMID: 40281006.
- Tran RL, Li T, de la Cerda J, Schuler FW, Khaled AS, Pudakalakatti S, Bhattacharya PK, Sinharay S, Pagel MD. Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI. Br J Cancer. e-Pub 2025. PMID: 39994445.
- Hsieh KL, Chen Q, Salzillo TC, Zhang J, Jiang X, Bhattacharya PK, Shams AS. Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, and Artificial Intelligence to Interrogate the Metabolic Evolution of Glioblastoma. Metabolites 14(8), 2024. e-Pub 2024.
- Tripathi S, Park JH, Pudakalakatti S, Bhattacharya PK, Kaipparettu BA, Levine H. A mechanistic modeling framework reveals the key principles underlying tumor metabolism. PLoS Comput Biol 18(2):e1009841, 2022. e-Pub 2022. PMID: 35148308.
- Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3), 2022. e-Pub 2022. PMID: 35163565.
- Kim J, Jo D, Yang SH, Joo CG, Whiting N, Pudakalakatti S, Seo H, Son HY, Min SJ, Bhattacharya P, Huh YM, Shim JH, Lee Y. 29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe. ACS Appl Mater Interfaces 13(48):56923-56930, 2021. e-Pub 2021. PMID: 34793118.
- Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI) 4(4):32, 2021. e-Pub 2021. PMID: 35937580.
- Salzillo TC, Mawoneke V, Weygand J, Shetty A, Gumin J, Zacharias NM, Gammon ST, Piwnica-Worms D, Fuller GN, Logothetis CJ, Lang FF, Bhattacharya PK. Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance. Cells 10(10):2621, 2021. e-Pub 2021. PMID: 34685601.
- Rao Y, Gammon ST, Sutton MN, Zacharias NM, Bhattacharya P, Piwnica-Worms. Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent mannger. J Bio Chem 297(1), 2021. e-Pub 2021. PMID: 34022218.
- Gray JP, Uddin MN, Chaudhari R, Sutton MN, Yang H, Rask P, Locke H, Engel BJ, Batistatou N, Wang J, Grindel BJ, Bhattacharya P, Gammon ST, Zhang S, Piwnica-Worms D, Kritzer JA, Lu Z, Bast RC, Millward SW. Directed evolution of cyclic peptides for inhibition of autophagy. Chem Sci 12(10):3526-3543, 2021. e-Pub 2021. PMID: 34163626.
- Zhang Y, Chandra V, Riquelme Sanchez E, Dutta P, Quesada PR, Rakoski A, Zoltan M, Arora N, Baydogan S, Horne W, Burks J, Xu H, Hussain P, Wang H, Gupta S, Maitra A, Bailey JM, Moghaddam SJ, Banerjee S, Sahin I, Bhattacharya PK, McAllister F. Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 217(12):e20190354, 2020. e-Pub 2020. PMID: 32860704.
- Jaiswal AR, Liu AJ, Pudakalakatti S, Dutta P, Jayaprakash P, Bartkowiak T, Ager CR, Wang ZQ, Reuben A, Cooper ZA, Ivan C, Ju Z, Nwajei F, Wang J, Davies MA, Davis RE, Wargo JA, Bhattacharya PK, Hong DS, Curran MA. Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype. Cancer Immunol Res 8(11):1365-1380, 2020. e-Pub 2020. PMID: 32917656.
- Lara OD, Bayraktar E, Amero P, Ma S, Ivan C, Hu W, Wang Y, Mangala LS, Dutta P, Bhattacharya P, Ashizawa AT, Lopez-Berestein G, Rodriguez-Aguayo C, Sood AK. Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer. Oncotarget 11(29):2819-2833, 2020. e-Pub 2020. PMID: 32754300.
- Dutta P, Pando SC, Mascaro M, Riquelme E, Zoltan M, Zacharias NM, Gammon ST, Piwnica-Worms D, Pagel MD, Sen S, Maitra A, Shams S, McAllister F, Bhattacharya PK. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. Int J Mol Sci 21(10):3722, 2020. e-Pub 2020. PMID: 32466260.
- Rao Y, Gammon S, Zacharias NM, Liu T, Salzillo T, Xi Y, Wang J, Bhattacharya\\b, Piwnica-Worms D. Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane. Proc Natl Acad Sci USA 2020 117(36):22378-22389, 2020. e-Pub 2020.
- Zacharias NM, Baran N, Shanmugavelandy SS, Lee J, Lujan JV, Dutta P, Millward SW, Cai T, Wood CG, Piwnica-Worms D, Konopleva M, Bhattacharya PK. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia. Mol Cancer Ther 18(11):1937-1946, 2019. e-Pub 2019. PMID: 31387889.
- Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer. J Proteome Res 18(7):2826-2834, 2019. e-Pub 2019. PMID: 31120258.
- Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
- Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol 21(1):86-94, 2019. e-Pub 2019. PMID: 29748904.
- Seo H, Choi I, Whiting N, Hu J, Luu QS, Pudakalakatti S, McCowan C, Kim Y, Zacharias N, Lee S, Bhattacharya P, Lee Y. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19(17):2143-2147, 2018. e-Pub 2018. PMID: 29779258.
- Zacharias NM, McCullough C, Shanmugavelandy S, Lee J, Lee Y, Dutta P, McHenry J, Nguyen L, Norton W, Jones LW, Bhattacharya PK. Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer. Sci Rep 7(1):16159, 2017. e-Pub 2017. PMID: 29170516.
- Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev 36(2):289-303. e-Pub 2017. PMID: 28762014.
- Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
- Whiting N, Hu J, Zacharias NM, Lokesh GL, Volk DE, Menter DG, Rupaimoole R, Previs R, Sood AK, Bhattacharya P. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham) 3(3):036001, 2016. e-Pub 2016. PMID: 27547777.
- Zacharias NM, McCullough CR, Wagner S, Sailasuta N, Chan HR, Lee Y, Hu J, Perman WH, Henneberg C, Ross BD, Bhattacharya P. Towards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate. J Mol Imaging Dyn 6(1), 2016. e-Pub 2016. PMID: 27547490.
- Benito J, Ramirez MS, Millward NZ, Velez J, Harutyunyan KG, Lu H, Shi YX, Matre P, Jacamo R, Ma H, Konoplev S, McQueen T, Volgin A, Protopopova M, Mu H, Lee J, Bhattacharya PK, Marszalek JR, Davis RE, Bankson JA, Cortes JE, Hart CP, Andreeff M, Konopleva M. Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models. Clin Cancer Res 22(7):1687-98, 2016. e-Pub 2016. PMID: 26603259.
- Jeong G, Lee JW, Gong G, Ko H, Choi I, Seo H, Lee Y, Zacharias Millward NM, Bhattacharya PK. Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo. Journal of Industrial and Engineering Chemistry 36:224-228, 2016. e-Pub 2016.
- Zand B, Previs RA, Zacharias NM, Rupaimoole R, Mitamura T, Nagaraja AS, Guindani M, Dalton HJ, Yang L, Baddour J, Achreja A, Hu W, Pecot CV, Ivan C, Wu SY, McCullough CR, Gharpure KM, Shoshan E, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Wang Y, Nick AM, Davies MA, Armaiz-Pena G, Liu J, Lutgendorf SK, Baggerly KA, Eli MB, Lopez-Berestein G, Nagrath D, Bhattacharya PK, Sood AK. Role of increased n-acetylaspartate levels in cancer. J Natl Cancer Inst 108(6):djv426, 2016. e-Pub 2016. PMID: 26819345.
- Rupaimoole R, Lee J, Haemmerle M, Ling H, Previs RA, Pradeep S, Wu SY, Ivan C, Ferracin M, Dennison JB, Millward NM, Nagaraja AS, Gharpure KM, McGuire M, Sam N, Armaiz-Pena GN, Sadaoui NC, Rodriguez-Aguayo C, Calin GA, Drapkin RI, Kovacs J, Mills GB, Zhang W, Lopez-Berestein G, Bhattacharya PK, Sood AK. Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep 13(11):2395-402, 2015. e-Pub 2015. PMID: 26686630.
- Lai SY, Fuller CD, Bhattacharya PK, Frank SJ. Metabolic Imaging as a Biomarker of Early Radiation Response in Tumors. Clin Cancer Res 21(22):4996-8, 2015. e-Pub 2015. PMID: 26232369.
- Whiting N, Hu J, Shah JV, Cassidy MC, Cressman E, Millward NZ, Menter DG, Marcus CM, Bhattacharya PK. Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles. Sci Rep 5:12842, 2015. e-Pub 2015. PMID: 26239953.
- Lee Y, Zacharias N, Piwnica-worms D, Bhattacharya PK. Chemical Reaction-Induced Multi-molecular Polarization (CRIMP). Chemical Communications 50 50(86):13030-3, 2014. e-Pub 2014. PMID: 25224323.
- Cassidy MC, Chan HR, Ross BD, Bhattacharya PK, Marcus CM. In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nanotechnol 8(5):363-8, 2013. e-Pub 2013. PMID: 23644571.
- Zacharias NM, Chan HR, Sailasuta N, Ross BD, Bhattacharya PK. Real-Time Molecular Imaging of Tricarboxylic Acid Cycle Metabolism. Journal of the American Chemical Society 134(2):934-943, 2012. e-Pub 2012. PMID: 22146049.
- Lingwood MD, Siaw TA, Sailasuta N, Abulseoud OA, Chan HR, Ross BD, Bhattacharya PK, Han S. Hyperpolarized Water as an MR Imaging Contrast Agent: Feasibility of in Vivo Imaging in a Rat Model. Radiology 265(2):418-425, 2012. e-Pub 2012. PMID: 22996746.
- Bhattacharya PK, Chekmenev E, Reynolds WF, Wagner S, Zacharias N, Chan HR, Bunger R, Ross BD. PHIP Hyperpolarized MR Receptor Imaging In Vivo: A Pilot Study of 13C Imaging of Atheroma in Mice. NMR in Biomedicine 24(Special Issue Research Article):1023-1028, 2011. e-Pub 2011. PMID: 21538638.
- Ross B, Tran T, Bhattacharya PK, Watterson DM, Sailasuta N. Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery. Current Topics in Medicinal Chemistry 11(1):93-114, 2011. e-Pub 2011. PMID: 20809893.
- Lingwood MD, Siaw TA, Sailasuta N, Ross BD, Bhattacharya PK, Han S. Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast. J Magn Reson 205(2):247-254, 2010. e-Pub 2010. PMID: 20541445.
- Ross BD, Bhattacharya PK, Wagner S, Tran T, Sailasuta N. Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism. AJNR Am J Neuroradiol 31(1):24-33, 2010. e-Pub 2010. PMID: 19875468.
- Perman WH, Bhattacharya PK, Leupold J, Lin AP, Harris KC, Norton VA, Hovener JB, Ross BD. Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP. Magnetic Resonance Imaging 28(4):459-465, 2010. e-Pub 2010. PMID: 20171034.
- Bhattacharya PK, Ross BD, Bünger R. Cardiovascular Applications of Hyperpolarized Contrast Media and Metabolic Tracers. Exp Biol Med (Maywood) 234(12):1395-1416, 2009. e-Pub 2009. PMID: 19934362.
- Chekmenev EY, Norton VA, Weitekamp DP, Bhattacharya PK. Hyperpolarized 1H NMR Employing Low γ Nucleus for Spin Polarization Storage. J Am Chem Soc 131(9):3164-3165, 2009. e-Pub 2009. PMID: 19256566.
- J-B H, Chekmenev EY, Harris KC, Perman WH, Tran TT, Ross BD, Bhattacharya PK. Quality assurance of PASADENA hyperpolarization for. MAGMA-Magnetic Resonance Materials in Physics, Biology and Medicine 22(2):123-134, 2009. e-Pub 2009. PMID: 19067009.
- Hovener JB, Chekmenev EY, Harris KC, Perman WH, Robertson LW, Ross BD, Bhattacharya PK. PASADENA Hyperpolarization of 13C Biomolecules: Equipment Design and Installation. MAGMA-Magnetic Resonance Materials in Physics, Biology and Medicine 22(2):111-121, 2009. e-Pub 2009. PMID: 19067008.
- Chekmenev EY, Hövener J, Norton VA, Harris K, Batchelder LS, Bhattacharya PK, Ross BD, Weitekamp DP. PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy. J Am Chem Soc 130(13):4212-3, 2008. e-Pub 2008. PMID: 18335934.
- Chekmenev EY, S-K C, Tofan D, Weitekamp DP, Ross BD, Bhattacharya PK. Fluorine-19 NMR Chemical Shift Probes Molecular Binding to Lipid Membranes. The Journal of Physical Chemistry B 112(20):6285-6287, 2008. e-Pub 2008. PMID: 18422359.
- Bhattacharya PK, Chekmenev EY, Harris KC, Perman WH, Li AP, Norton VA, Chow CT, Ross BD, Weitekamp DP. Towards Hyperpolarized (13)C-succinate Imaging of Brain Cancer. J Magn Reson 186(1):150-155, 2007. e-Pub 2007.
- Bhattcharya PK, Harris K, Lin AP, Mansson M, Norton VA, Perman WH, Weitekamp DP, Ross BD. Ultra-fast Three Dimensional Imaging of Hyperpolarized 13C In Vivo. Biology and Medicine Magnetic Resonance Materials in Physics 18(5):245-256, 2005. e-Pub 2005.
- Bhattacharya PK, Lawson HJ, Barton JK. 1H NMR Studies of Nickel(II) Complexes Bound to Oligonucleotides: A Novel Technique for Distinguishing the Binding Locations of Metal Complexes in DNA. Inorg Chem 42(26):8811-8817, 2003. e-Pub 2003. PMID: 14686861.
- Ross B, Lin A, Harris K, Bhattacharya PK, Schweinsburg B. Clinical experience with 13C MRS in vivo. NMR in Biomedicine 16(6-7):358-369, 2003. e-Pub 2003. PMID: 14679500.
- Bhattacharya PK, Cha J, Barton JK. 1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches. Nucleic Acids Res 30(21):4740-50, 2002. e-Pub 2002. PMID: 12409465.
- Delaney S, Pascaly M, Bhattacharya PK, Han K, Barton JK. Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation. Inorg Chem 41(7):1966-74, 2002. e-Pub 2002. PMID: 11925195.
- Bhattacharya PK, Barton JK. Influence of Intervening Mismatches on Long-Range Guanine Oxidation in DNA Duplexes. J Am Chem Soc 123(36):8649-8656, 2001. e-Pub 2001. PMID: 11535068.
- Hu J, Whiting N, Constantinou PE, Farach-Carson MC, Carson DD, Bhattacharya PK. Real-time Molecular MRI with Hyperpolarized Silicon Particles, "Characterization Tools for Nanoscience & Nanotechnology". Springer.
Professional Educational Materials
- Lujan JV, Millward NZ, Rakheja D, Bhagat TD, Lee J, Dutta P, Gonzalez D, Andreeff M, Bhattacharya PK, Verma A, Konopleva M. Role of Glutamine in Metabolic and Epigenetic Reprogramming in AML, 2015.
Book Chapters
- Hu J, Salzillo TC, Sailasuta N, Lang FF, Bhattacharya PK. Interrogating IDH Mutation in Brain Tumor: Magnetic Resonance and Hyperpolarization. In: Top Magn Reson Imaging. Top Magn Reson Imaging, 2017.
Patents
- Bhattacharya P, Ross BD. Imaging Agents and Methods of Use Thereof. Patent Number: US2008/050932.
- Bhattacharya P, Ross BD. Imaging Agents and Methods of Use Thereof. Patent Number: US2006/039974.
- Bhattacharya P, Ross BD. Methods and Apparatus for PASADENA Hyperpolarization. Patent Number: PCT/US09/40568.
- Bhattacharya P, Ross BD. Imaging of Genetic Material with Magnetic Resonance. Patent Number: US2008/078999.
Patient Reviews
CV information above last modified September 17, 2025