Pratip K. Bhattacharya, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
About Dr. Bhattacharya
The focus of research in Dr. Bhattacharya's laboratory in the Department of Cancer Systems Imaging is the development of real-time metabolic and imaging applications by hyperpolarization. We are exploring novel ways to utilize Magnetic Resonance Imaging (MRI) to create more detailed metabolic and molecular imaging studies by employing hyperpolarized, non-radioactive carbon 13 (13C) and nitrogen 15 (15N)-labeled compounds and silicon particles and nanoparticles (SiNPs) to tag specific metabolic and biochemical structures and functions that are altered in cancer. Hyperpolarized MR is a non-toxic, non-radioactive method for non-invasively assessing tissue metabolism and other physiologic properties. Hyperpolarization allows for a >10,000-fold signal enhancement relative to conventional MRI or MRS. After hyperpolarization, the signal enhancement can be retained on the metabolites of the hyperpolarized molecules for several minutes. Dr. Bhattacharya’s, lab is working on techniques to extend this relaxation time so that more detailed metabolic and molecular imaging studies can be considered.
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Magnetic Resonance laboratory is involved in three primary areas of research:
· Real time metabolic MR imaging with hyperpolarized 13C and 15N labeled non-radioactive compounds. The goal of this research is to use mostly endogenous compounds to track different metabolic pathways in vivo in real time both in preclinical animal models and in human applications.
· Real-time molecular MR imaging with hyperpolarized silicon nanoparticle (SiNPs) functionalized to target specific biological functions and structure. Hyperpolarized SiNPs have opened the door for targeted functional imaging by MR that used to be in the realm of PET and SPECT. Due to the simple surface chemistry, the hyperpolarized SiNPs can serve as a nanoplatform, allowing a variety of targeting agents and potentially therapeutic drugs to be loaded onto the particles, which enables real-time targeted Theranostics imaging studies with an imaging time window of roughly one hour.
· High resolution MR metabolomics of animal and human tissues. To complement the real-time in vivo hyperpolarization studies, we have developed an MR based metabolomics program to generate comprehensive metabolic profiles of cancerous and non-cancerous tissues in vitro.
Present Title & Affiliation
Primary Appointment
Graduate Faculty, Department of Graduate School of Biomedical Sciences, Division of Diagnostic Imaging, The University of Texas Health Science Center, Houston, TX
Associate Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Graduate Faculty, Department of Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX
Associate Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Hyperpolarization: liquid and solid state, Real-time molecular and metabolic imaging in vivo, Silicon nanoparticle hyperpolarization for targeted MRI and nanochemistry, Parahydrogen Induced Polarization and Dynamic Nuclear Polarization
Education & Training
Degree-Granting Education
| 2005 | California Institute of Technology, Pasadena, California, US, Chemistry, Prof. Jacqueline K. Barton, Ph.D |
Postgraduate Training
| 2005-2006 | James G. Boswell Fellowship, MR Physics, Huntington Medical Research Institutes/Caltech, Pasadena, California |
Experience & Service
Other Appointments/Responsibilities
James G. Boswell Fellow, California Institute of Technology & MR Unit, Huntington Medical Research Institutes, Pasadena, CA, 2004 - 2006
Graduate Research Assistant, California Institute of Technology, Pasadena, CA, 2000 - 2004
Institutional Committee Activities
Committee Member, Department of Veterinary Medicine, 2019 - 2019
Committee Member, Department of Radiation Physics, 2018 - 2018
Member, Center for Advanced Biomedical Imaging (CABI) MR Operations Committee, 2017 - Present
Co-Chair, Cancer Metabolism Working Group, 2017 - Present
Committee Member, SPINlab Steering Committee, 2016 - Present
Committee Member, Diagnostic Imaging Strategic Plan Functional Committee, 2016 - Present
Representative, Keck Executive Committee for Gulf Coast Consortia, 2016 - Present
Committee Member, Postdoctoral Advisory Committee, 2015 - Present
Committee Member, Institutional Research Grant (IRG Clinical) Committee, 2015 - Present
Committee Member, CCSG NMR Shared Resource Facility Steering Committee, 2015 - Present
Committee Member, Diagnostic Imaging Educational Functional Committee, 2014 - Present
Co-Champion, Diagnostic Imaging Research Strategic Planning Committee, 2014 - Present
Committee Member, MD Anderson Faculty Health Advisory Committee, 2013 - 2016
Honors & Awards
| 2022 | Summa Cum Laude Merit Award, 30th Annual ISMRM Meeting |
| 2021 | Outstanding Research Award, Basic and/or Translational Research,, Department of Diagnostic Imaging, UT MD Anderson Cancer Center |
| 2018 | Summa Cum Laude Merit Award, 26th Annual ISMRM Meeting |
| 2017 | Summa Cum Laude Merit Award, 25th Annual ISMRM Meeting |
| 2016 | Summa Cum Laude Merit Award, 24th Annual ISMRM Meeting |
| 2015 | Summa Cum Laude Merit Award, 23rd Annual ISMRM Meeting |
| 2014 | Robert M. Chamberlain Distinguished Mentor Award, Robert M. Chamberlain Distinguished Mentor |
| 2014 | Finalist 2014 Robert M. Chamberlain Distinguished Mentor Award, Robert M. Chamberlain Distinguished Mentor |
| 2013 | Summa Cum Laude Merit Award, 21st Annual ISMRM Meeting |
| 2012 | Summa Cum Laude Merit Award, 20th Annual ISMRM Meeting |
| 2012 | Institutional Start-up Award, University of Texas MD Anderson Cancer Center |
| 2011 | Best Poster, World Molecular Imaging Congress |
| 2007 | AHA Young Investigators Forum Best Poster, AHA Young Investigators Forum, San Diego, CA |
| 2007 | New Investigator Award, Tobacco Related Disease Research Program |
| 2006 | Mildred Swanson Award, American Brain Tumor Association Fellowship |
| 2006 | American Heart Association Fellowship, American Heart Association Fellowship |
| 2005 | James G. Boswell Fellowship |
| 2000 | Dow Travel Fellowship |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Tran RL, Li T, de la Cerda J, Schuler FW, Khaled AS, Pudakalakatti S, Bhattacharya PK, Sinharay S, Pagel MD. Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI. Br J Cancer. e-Pub 2025. PMID: 39994445.
- Hsieh KL, Chen Q, Salzillo TC, Zhang J, Jiang X, Bhattacharya PK, Shams AS. Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, and Artificial Intelligence to Interrogate the Metabolic Evolution of Glioblastoma. Metabolites 14(8), 2024. e-Pub 2024.
- Tripathi S, Park JH, Pudakalakatti S, Bhattacharya PK, Kaipparettu BA, Levine H. A mechanistic modeling framework reveals the key principles underlying tumor metabolism. PLoS Comput Biol 18(2):e1009841, 2022. e-Pub 2022. PMID: 35148308.
- Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3), 2022. e-Pub 2022. PMID: 35163565.
- Kim J, Jo D, Yang SH, Joo CG, Whiting N, Pudakalakatti S, Seo H, Son HY, Min SJ, Bhattacharya P, Huh YM, Shim JH, Lee Y. 29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe. ACS Appl Mater Interfaces 13(48):56923-56930, 2021. e-Pub 2021. PMID: 34793118.
- Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI) 4(4):32, 2021. e-Pub 2021. PMID: 35937580.
- Salzillo TC, Mawoneke V, Weygand J, Shetty A, Gumin J, Zacharias NM, Gammon ST, Piwnica-Worms D, Fuller GN, Logothetis CJ, Lang FF, Bhattacharya PK. Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance. Cells 10(10):2621, 2021. e-Pub 2021. PMID: 34685601.
- Rao Y, Gammon ST, Sutton MN, Zacharias NM, Bhattacharya P, Piwnica-Worms. Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent mannger. J Bio Chem 297(1), 2021. e-Pub 2021. PMID: 34022218.
- Gray JP, Uddin MN, Chaudhari R, Sutton MN, Yang H, Rask P, Locke H, Engel BJ, Batistatou N, Wang J, Grindel BJ, Bhattacharya P, Gammon ST, Zhang S, Piwnica-Worms D, Kritzer JA, Lu Z, Bast RC, Millward SW. Directed evolution of cyclic peptides for inhibition of autophagy. Chem Sci 12(10):3526-3543, 2021. e-Pub 2021. PMID: 34163626.
- Zhang Y, Chandra V, Riquelme Sanchez E, Dutta P, Quesada PR, Rakoski A, Zoltan M, Arora N, Baydogan S, Horne W, Burks J, Xu H, Hussain P, Wang H, Gupta S, Maitra A, Bailey JM, Moghaddam SJ, Banerjee S, Sahin I, Bhattacharya PK, McAllister F. Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 217(12):e20190354, 2020. e-Pub 2020. PMID: 32860704.
- Jaiswal AR, Liu AJ, Pudakalakatti S, Dutta P, Jayaprakash P, Bartkowiak T, Ager CR, Wang ZQ, Reuben A, Cooper ZA, Ivan C, Ju Z, Nwajei F, Wang J, Davies MA, Davis RE, Wargo JA, Bhattacharya PK, Hong DS, Curran MA. Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype. Cancer Immunol Res 8(11):1365-1380, 2020. e-Pub 2020. PMID: 32917656.
- Lara OD, Bayraktar E, Amero P, Ma S, Ivan C, Hu W, Wang Y, Mangala LS, Dutta P, Bhattacharya P, Ashizawa AT, Lopez-Berestein G, Rodriguez-Aguayo C, Sood AK. Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer. Oncotarget 11(29):2819-2833, 2020. e-Pub 2020. PMID: 32754300.
- Dutta P, Pando SC, Mascaro M, Riquelme E, Zoltan M, Zacharias NM, Gammon ST, Piwnica-Worms D, Pagel MD, Sen S, Maitra A, Shams S, McAllister F, Bhattacharya PK. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. Int J Mol Sci 21(10):3722, 2020. e-Pub 2020. PMID: 32466260.
- Rao Y, Gammon S, Zacharias NM, Liu T, Salzillo T, Xi Y, Wang J, Bhattacharya\\b, Piwnica-Worms D. Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane. Proc Natl Acad Sci USA 2020 117(36):22378-22389, 2020. e-Pub 2020.
- Zacharias NM, Baran N, Shanmugavelandy SS, Lee J, Lujan JV, Dutta P, Millward SW, Cai T, Wood CG, Piwnica-Worms D, Konopleva M, Bhattacharya PK. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia. Mol Cancer Ther 18(11):1937-1946, 2019. e-Pub 2019. PMID: 31387889.
- Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer. J Proteome Res 18(7):2826-2834, 2019. e-Pub 2019. PMID: 31120258.
- Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
- Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol 21(1):86-94, 2019. e-Pub 2019. PMID: 29748904.
- Seo H, Choi I, Whiting N, Hu J, Luu QS, Pudakalakatti S, McCowan C, Kim Y, Zacharias N, Lee S, Bhattacharya P, Lee Y. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19(17):2143-2147, 2018. e-Pub 2018. PMID: 29779258.
- Zacharias NM, McCullough C, Shanmugavelandy S, Lee J, Lee Y, Dutta P, McHenry J, Nguyen L, Norton W, Jones LW, Bhattacharya PK. Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer. Sci Rep 7(1):16159, 2017. e-Pub 2017. PMID: 29170516.
- Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev 36(2):289-303. e-Pub 2017. PMID: 28762014.
- Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
- Whiting N, Hu J, Zacharias NM, Lokesh GL, Volk DE, Menter DG, Rupaimoole R, Previs R, Sood AK, Bhattacharya P. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham) 3(3):036001, 2016. e-Pub 2016. PMID: 27547777.
- Zacharias NM, McCullough CR, Wagner S, Sailasuta N, Chan HR, Lee Y, Hu J, Perman WH, Henneberg C, Ross BD, Bhattacharya P. Towards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate. J Mol Imaging Dyn 6(1), 2016. e-Pub 2016. PMID: 27547490.
- Jeong G, Lee JW, Gong G, Ko H, Choi I, Seo H, Lee Y, Zacharias Millward NM, Bhattacharya PK. Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo. Journal of Industrial and Engineering Chemistry 36:224-228, 2016. e-Pub 2016.
- Benito J, Ramirez MS, Millward NZ, Velez J, Harutyunyan KG, Lu H, Shi YX, Matre P, Jacamo R, Ma H, Konoplev S, McQueen T, Volgin A, Protopopova M, Mu H, Lee J, Bhattacharya PK, Marszalek JR, Davis RE, Bankson JA, Cortes JE, Hart CP, Andreeff M, Konopleva M. Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models. Clin Cancer Res 22(7):1687-98, 2016. e-Pub 2016. PMID: 26603259.
- Zand B, Previs RA, Zacharias NM, Rupaimoole R, Mitamura T, Nagaraja AS, Guindani M, Dalton HJ, Yang L, Baddour J, Achreja A, Hu W, Pecot CV, Ivan C, Wu SY, McCullough CR, Gharpure KM, Shoshan E, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Wang Y, Nick AM, Davies MA, Armaiz-Pena G, Liu J, Lutgendorf SK, Baggerly KA, Eli MB, Lopez-Berestein G, Nagrath D, Bhattacharya PK, Sood AK. Role of increased n-acetylaspartate levels in cancer. J Natl Cancer Inst 108(6):djv426, 2016. e-Pub 2016. PMID: 26819345.
- Rupaimoole R, Lee J, Haemmerle M, Ling H, Previs RA, Pradeep S, Wu SY, Ivan C, Ferracin M, Dennison JB, Millward NM, Nagaraja AS, Gharpure KM, McGuire M, Sam N, Armaiz-Pena GN, Sadaoui NC, Rodriguez-Aguayo C, Calin GA, Drapkin RI, Kovacs J, Mills GB, Zhang W, Lopez-Berestein G, Bhattacharya PK, Sood AK. Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep 13(11):2395-402, 2015. e-Pub 2015. PMID: 26686630.
- Lai SY, Fuller CD, Bhattacharya PK, Frank SJ. Metabolic Imaging as a Biomarker of Early Radiation Response in Tumors. Clin Cancer Res 21(22):4996-8, 2015. e-Pub 2015. PMID: 26232369.
- Whiting N, Hu J, Shah JV, Cassidy MC, Cressman E, Millward NZ, Menter DG, Marcus CM, Bhattacharya PK. Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles. Sci Rep 5:12842, 2015. e-Pub 2015. PMID: 26239953.
- Lee Y, Zacharias N, Piwnica-worms D, Bhattacharya PK. Chemical Reaction-Induced Multi-molecular Polarization (CRIMP). Chemical Communications 50 50(86):13030-3, 2014. e-Pub 2014. PMID: 25224323.
- Cassidy MC, Chan HR, Ross BD, Bhattacharya PK, Marcus CM. In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nanotechnol 8(5):363-8, 2013. e-Pub 2013. PMID: 23644571.
- Lingwood MD, Siaw TA, Sailasuta N, Abulseoud OA, Chan HR, Ross BD, Bhattacharya PK, Han S. Hyperpolarized Water as an MR Imaging Contrast Agent: Feasibility of in Vivo Imaging in a Rat Model. Radiology 265(2):418-425, 2012. e-Pub 2012. PMID: 22996746.
- Zacharias NM, Chan HR, Sailasuta N, Ross BD, Bhattacharya PK. Real-Time Molecular Imaging of Tricarboxylic Acid Cycle Metabolism. Journal of the American Chemical Society 134(2):934-943, 2012. e-Pub 2012. PMID: 22146049.
- Bhattacharya PK, Chekmenev E, Reynolds WF, Wagner S, Zacharias N, Chan HR, Bunger R, Ross BD. PHIP Hyperpolarized MR Receptor Imaging In Vivo: A Pilot Study of 13C Imaging of Atheroma in Mice. NMR in Biomedicine 24(Special Issue Research Article):1023-1028, 2011. e-Pub 2011. PMID: 21538638.
- Ross B, Tran T, Bhattacharya PK, Watterson DM, Sailasuta N. Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery. Current Topics in Medicinal Chemistry 11(1):93-114, 2011. e-Pub 2011. PMID: 20809893.
- Lingwood MD, Siaw TA, Sailasuta N, Ross BD, Bhattacharya PK, Han S. Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast. J Magn Reson 205(2):247-254, 2010. e-Pub 2010. PMID: 20541445.
- Ross BD, Bhattacharya PK, Wagner S, Tran T, Sailasuta N. Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism. AJNR Am J Neuroradiol 31(1):24-33, 2010. e-Pub 2010. PMID: 19875468.
- Perman WH, Bhattacharya PK, Leupold J, Lin AP, Harris KC, Norton VA, Hovener JB, Ross BD. Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP. Magnetic Resonance Imaging 28(4):459-465, 2010. e-Pub 2010. PMID: 20171034.
- Bhattacharya PK, Ross BD, Bünger R. Cardiovascular Applications of Hyperpolarized Contrast Media and Metabolic Tracers. Exp Biol Med (Maywood) 234(12):1395-1416, 2009. e-Pub 2009. PMID: 19934362.
- Chekmenev EY, Norton VA, Weitekamp DP, Bhattacharya PK. Hyperpolarized 1H NMR Employing Low γ Nucleus for Spin Polarization Storage. J Am Chem Soc 131(9):3164-3165, 2009. e-Pub 2009. PMID: 19256566.
- J-B H, Chekmenev EY, Harris KC, Perman WH, Tran TT, Ross BD, Bhattacharya PK. Quality assurance of PASADENA hyperpolarization for. MAGMA-Magnetic Resonance Materials in Physics, Biology and Medicine 22(2):123-134, 2009. e-Pub 2009. PMID: 19067009.
- Hovener JB, Chekmenev EY, Harris KC, Perman WH, Robertson LW, Ross BD, Bhattacharya PK. PASADENA Hyperpolarization of 13C Biomolecules: Equipment Design and Installation. MAGMA-Magnetic Resonance Materials in Physics, Biology and Medicine 22(2):111-121, 2009. e-Pub 2009. PMID: 19067008.
- Chekmenev EY, Hövener J, Norton VA, Harris K, Batchelder LS, Bhattacharya PK, Ross BD, Weitekamp DP. PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy. J Am Chem Soc 130(13):4212-3, 2008. e-Pub 2008. PMID: 18335934.
- Chekmenev EY, S-K C, Tofan D, Weitekamp DP, Ross BD, Bhattacharya PK. Fluorine-19 NMR Chemical Shift Probes Molecular Binding to Lipid Membranes. The Journal of Physical Chemistry B 112(20):6285-6287, 2008. e-Pub 2008. PMID: 18422359.
- Bhattacharya PK, Chekmenev EY, Harris KC, Perman WH, Li AP, Norton VA, Chow CT, Ross BD, Weitekamp DP. Towards Hyperpolarized (13)C-succinate Imaging of Brain Cancer. J Magn Reson 186(1):150-155, 2007. e-Pub 2007.
- Bhattcharya PK, Harris K, Lin AP, Mansson M, Norton VA, Perman WH, Weitekamp DP, Ross BD. Ultra-fast Three Dimensional Imaging of Hyperpolarized 13C In Vivo. Biology and Medicine Magnetic Resonance Materials in Physics 18(5):245-256, 2005. e-Pub 2005.
- Bhattacharya PK, Lawson HJ, Barton JK. 1H NMR Studies of Nickel(II) Complexes Bound to Oligonucleotides: A Novel Technique for Distinguishing the Binding Locations of Metal Complexes in DNA. Inorg Chem 42(26):8811-8817, 2003. e-Pub 2003. PMID: 14686861.
- Ross B, Lin A, Harris K, Bhattacharya PK, Schweinsburg B. Clinical experience with 13C MRS in vivo. NMR in Biomedicine 16(6-7):358-369, 2003. e-Pub 2003. PMID: 14679500.
- Bhattacharya PK, Cha J, Barton JK. 1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches. Nucleic Acids Res 30(21):4740-50, 2002. e-Pub 2002. PMID: 12409465.
- Delaney S, Pascaly M, Bhattacharya PK, Han K, Barton JK. Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation. Inorg Chem 41(7):1966-74, 2002. e-Pub 2002. PMID: 11925195.
- Bhattacharya PK, Barton JK. Influence of Intervening Mismatches on Long-Range Guanine Oxidation in DNA Duplexes. J Am Chem Soc 123(36):8649-8656, 2001. e-Pub 2001. PMID: 11535068.
- Hu J, Whiting N, Constantinou PE, Farach-Carson MC, Carson DD, Bhattacharya PK. Real-time Molecular MRI with Hyperpolarized Silicon Particles, "Characterization Tools for Nanoscience & Nanotechnology". Springer.
Manuals, Teaching Aids, Other Teaching Publications
- Lujan JV, Millward NZ, Rakheja D, Bhagat TD, Lee J, Dutta P, Gonzalez D, Andreeff M, Bhattacharya PK, Verma A, Konopleva M. Role of Glutamine in Metabolic and Epigenetic Reprogramming in AML, 2015.
Book Chapters
- Hu J, Salzillo TC, Sailasuta N, Lang FF, Bhattacharya PK. Interrogating IDH Mutation in Brain Tumor: Magnetic Resonance and Hyperpolarization. In: Top Magn Reson Imaging. Top Magn Reson Imaging, 2017.
Selected Presentations & Talks
Local Presentations
- 2023. Career Conversation for Summer Experience. Conference. UT MD Anderson Cancer Center. Houston, TX, US.
- 2023. Successful Scientist. Conference. UT MD Anderson Cancer Center. Houston, TX, US.
Regional Presentations
- Imaging gene expression, nanoparticles and metabolism. Conference. UT MD Anderson Cancer Center, US.
National Presentations
- 2021. Future of Hyperpolarization Research in Biomedicine. Conference. Parahydrogen Enhanced Resonance Meeting (PERM), Virtual Symposium, US.
- 2018. Imaging Early Stage Pancreatic Cancer by Hyperpolarized Metabolic Imaging. Invited. Annual Conference of Pancreatic Cancer Action Network (PanCan). San Diego, CA, US.
- 2018. Targeted Molecular Imaging with Hyperpolarized Silicon Particles. Invited. AACR-SNMMI Joint Conference. San Diego, CA, US.
- 2017. Assessing Metabolic Intervention in Acute Myeloid Leukemia with a Glutaminase Inhibitor by Hyperpolarized magnetic Resonance,. Conference. International Society for Magnetic Resonance in Medicine. Honolulu, HI, US.
- 2016. Metabolic Imaging of Cancer Systems. Conference. AACR Annual Meeting. New Orleans, LA, US.
- 2016. Understanding Metabolic Alternations in Ovarian Cancer. Invited. International Workshop on Hyperpolarized Carbon-13 and its Applications in Metabolic Imaging. Philadelphia, PA, US.
- 2015. Metabolic and Molecular Imaging by Hyperpolarized NMR. Invited. Annual Meeting of American Chemical Society. Denver, CO, US.
- 2015. Developing Hyperpolarized Silicon Particles for Advanced Biomedical Imaging Applications. Conference. Society of Photo-optical Instrumental Engineers Conference (SPIE)-Medical Imaging. Orlando, FL, US.
- 2014. International Council on Magnetic Resonance in Biological Systems. Invited. International Council on Magnetic Resonance in Biological Systems. Dallas, TX, US.
- 2014. Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Nanoparticles. Conference. 55th Experimental Nuclear Magnetic Resonance Conference. Boston, MA, US.
- 2013. N/A. Conference. Experimental NMR Conference. Asilomar, CA, US.
- 2013. NIH/NINDS Curing the Epilepsies 2013. Conference. Pathways Forward Conference. Balitimore, MD, US.
- 2011. Metabolic and Molecular Imaging by Hyperpolarization. Invited. National Cancer Institute Translational Meeting. Washington DC, US.
- 2010. Real time imaging of TCA cycle by hyperpolarization. Invited. Gordon Conference In Vivo MR. Andover, NH, US.
- 2009. Imaging Plaque by Hyperpolarization. Invited. Tobacco Related Disease Research Program Biannual Meeting, CA, US.
- 2008. Real-time Cardiovascular Imaging by Hyperpolarization. Invited. 10th Society of Cardiovascular MR Annual Conference. Los Angeles, CA, US.
- 2005. Ultrafast Three Dimensional Imaging of Hyperpolarized 13C In-Vivo. Invited. 13th ISMRM Annual Scientific Meeting. Miami, FL, US.
International Presentations
- 2019. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia. Invited. WMIC. Montreal, US.
- 2019. Real-time Imaging of Aspirin Biodistribution and Metabolism in viv. Invited. WMIC. Montreal, US.
- 2019. Imaging the Metabolic Evolution of Patient-Derived Glioblastoma Xenografts in vivo with Hyperpolarized Magnetic Resonance During Tumor Development and Following Radiation Therap. Invited. WMIC. Montreal, US.
- 2019. Cardiology, Inflammation, Immunology & Infection, Metabolism, Methodology: Machine Learning & Data Processing. Conference. WMIC. Montreal, US.
- 2019. Assessing Early Efficacy of Antiandrogen Drug Treatment in PDX Model of Prostate Cancer by Hyperpolarized Metabolic MRI: A Comparative Study with FDG-PET Imaging. Conference. WMIC. Montreal, US.
- 2015. Towards Targeted Molecular Imaging of Colorectal Cancer by Hyperpolarized Silicon Particles Functionalized with Mucin Antibody. Conference. International Society for Magnetic Resonance in Medicine. Toronto, CA.
- 2014. Targeted Metabolic Imaging In vivo by Hyperpolarized Silicon Nanoparticles. Conference. International Society for Magnetic Resonance in Medicine. Milam, IT.
- 2012. Hyperpolarized Water as an MRI Contrast Agent. Invited. MCT Global Outreach Program, ISMRM. Bangkok, TH.
- 2007. Real-time Molecular Imaging by Hyperpolarization. Invited. 5th WATCH Conference. New Delhi, IN.
Formal Peers
- 2018. Imaging Cancer at an Early Stage: Metabolic and Molecular Imaging. Invited. Gulf Coast Consortia, Rice University. Houston, TX, US.
- 2018. Targeted Molecular Imaging in Real-time,. Invited. UT MD Anderson Cancer Center. Houston, TX, US.
- 2017. Real-time Imaging. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2014. Metabolic Imaging. Invited. MDACC. Houston, TX, US.
- 2014. The Dawn of Real-time Molecular and Metabolic Imaging by Hyperpolarization. Invited. MDACC. Houston, TX, US.
- 2013. Real-time Molecular and Metabolic Imaging by Hyperpolarization. Invited. Rice University. Houston, TX, US.
- 2012. Real-time Molecular Imaging of the TCA Cycle Metabolism. Invited. Virginia Tech Carilion School of Medicine. Roanoke, VA, US.
- 2010. Fast Volumetric Spatial-spectral MR Imaging of Hyperpolarized 13C-labeled Compounds Using Multiple Echo 3D bSSFP. Invited. Wesleyan College. Middletown, CT, US.
- 2010. Parahydrogen Induced Polarization. Invited. Cedars Sinai Medical Center. Los Angeles, CA, US.
- 2007. Towards Hyperpolarized (13)C-succinate Imaging of Brain Cancer. Invited. Cambridge University. Cambridge, GB.
- Towards real-time metabolic imaging of pancreatic cancer. Invited. Gulf Coast Consortia. Houston, TX, US.
Grant & Contract Support
| Date: | 2025 - 2028 |
| Title: | Does Alzheimer's disease sensitize subjects to chemo-brain? |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | AZ240284 |
| Date: | 2025 - 2030 |
| Title: | Does Alzheimer's Disease Sensitize Subjects to Chemo-Brain? |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | GRANT14203592 |
| Date: | 2025 - 2027 |
| Title: | Does Aβ plaque sensitize subjects to chemo-brain? |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | GRANT14181042 |
| Date: | 2025 - 2028 |
| Title: | Does Alzheimer’s Disease sensitize subjects to chemo-brain? |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP250362 |
| Date: | 2025 - 2028 |
| Title: | Sensitizing high grade serous ovarian cancer to immunotherapy |
| Funding Source: | Ovarian Cancer Research Alliance (OCRA) |
| Role: | Mentor |
| ID: | ECIG-2025-3-2055 |
| Date: | 2025 - 2026 |
| Title: | Cryogen-Free Preclinical 7T MRI Scanner |
| Funding Source: | National Institutes of Health/OD |
| Role: | Major User |
| ID: | S10038216 |
| Date: | 2024 - 2029 |
| Title: | Advancing Research Careers (ARC) UE5 Program |
| Funding Source: | NIH/NIGMS |
| Role: | Bridge Coach (Career Mentor) |
| ID: | UE5GM156832 |
| Date: | 2024 - 2026 |
| Title: | Molecular Imaging for Interrogating Early Detection and Early Therapeutic Efficacy in Alzheimer's Disease |
| Funding Source: | Md Anderson Cancer Center Institutional Research Grant |
| Role: | PI |
| ID: | N/A |
| Date: | 2024 - 2025 |
| Title: | Does AB plaque burden sensitize patients to chemo-brain? |
| Funding Source: | MD Anderson Neurocancer Program |
| Role: | Co-PI |
| ID: | N/A |
| Date: | 2024 - 2025 |
| Title: | Early diagnosis and risk stratification of colorectal cancer using hyperpolarized magnetic resonance imaging |
| Funding Source: | MD Anderson Odyssey Fellowship |
| Role: | Mentor |
| ID: | N/A |
| Date: | 2024 - 2029 |
| Title: | Deciphering monocarboxylate metabolism in health and disease |
| Funding Source: | Welch Foundation |
| Role: | Co-I |
| ID: | 1327179 |
| Date: | 2024 - 2027 |
| Title: | Targeted hyperpolarized molecular beacons for early detection and treatment of colorectal cancer |
| Funding Source: | Jane Coffin Childs Memorial Fund for Medical Research |
| Role: | Mentor |
| ID: | FP00021658 |
| Date: | 2024 - 2027 |
| Title: | Overcoming metabolically induced cancer treatment resistance by targeting intratumoral lactic acid producing bacteria |
| Funding Source: | Damon Runyon Cancer Research Foundation |
| Role: | Collaborator |
| ID: | 2024.01 - L.Colbert - Damon Runyon Fndtn - FP21878 |
| Date: | 2024 - 2027 |
| Title: | Development of novel strategies to revert immunotherapy resistance in melanoma |
| Funding Source: | Melanoma Research Alliance |
| Role: | Mentor |
| ID: | FP00021145 |
| Date: | 2024 - 2027 |
| Title: | Targeting of metabolic crosstalk between leukemia and macrophages as a therapeutic strategy for disease eradication and restoration of innate immune system |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP240324 |
| Date: | 2024 - 2027 |
| Title: | Artificial Intelligence for early identification of androgen-indifferent, lethal prostate cancer and therapy selection |
| Funding Source: | Rice University/CPRIT |
| Role: | Co-PI |
| ID: | RP240096 |
| Date: | 2024 - 2029 |
| Title: | The Academy at MD Anderson UTHealth Houston Graduate School - Maximizing Opportunities for Training, Development, and Community |
| Funding Source: | NIH/NIGMS |
| Role: | Mentor |
| ID: | 1T32GM152796-01 |
| Date: | 2023 - 2025 |
| Title: | Development of Silicon Nanoparticles as Molecular Beacons for Targeted Molecular Imaging |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | FP00018242 |
| Date: | 2023 - 2026 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | PA220132 |
| Date: | 2023 - 2025 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| ID: | 1F99CA284365-01 / FP00017852 |
| Date: | 2023 - 2025 |
| Title: | Hyperpolarized molecular beacons for early detection of colorectal cancer |
| Funding Source: | CPRTP Janice Davis Gordon Memorial in Colorectal Cancer Prevention |
| Role: | Mentor |
| ID: | N/A |
| Date: | 2023 - 2026 |
| Title: | Artificial Intelligence for classifying drug sensitive and resistant sub-types of lethal prostate cancer for assessment of therapeutic efficacy |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator-MDACC |
| ID: | FP00017358 |
| Date: | 2023 - 2028 |
| Title: | Creating therapeutic vulnerabilities in pancreatic cancer by blocking Yap1-Cox2 adaptive signaling with Statin and Aspirin |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2025 |
| Title: | Enzalutamide Pretreatment Sensitizes Prostate Cancer to Metabolic Inhibitors |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01 CA277276-01A1 |
| Date: | 2023 - 2028 |
| Title: | Exercise, glycolysis, and T cell therapy for melanoma |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | FP00018661 |
| Date: | 2023 - 2028 |
| Title: | MD Anderson Endometrial SPORE |
| Funding Source: | NIH/NCI |
| Role: | Internal Advisory Board Member |
| ID: | CA098258 |
| Date: | 2023 - 2025 |
| Title: | Employing AI to Predict Clinical Outcomes in Ovarian Cancer |
| Funding Source: | Ovarian Cancer Research Alliance (OCRA)/San Jose State University Research Foundation |
| Role: | Co-I |
| Date: | 2023 - 2026 |
| Title: | Targeting Lactate Transporters and OXPHOS Pathway in Castrate-Resistant Prostate Cancer |
| Funding Source: | Mt. Sinai Medical Center |
| Role: | Co-I |
| ID: | PC220435 |
| Date: | 2023 - 2025 |
| Title: | Imaging Metabolic Reprogramming in Prostate Cancer |
| Funding Source: | CPRIT/UTHealth at Texas Medical Center |
| Role: | Principal Investigator-MDACC |
| ID: | FP00020958 |
| Date: | 2023 - 2026 |
| Title: | Conquering gemcitabine resistance in pancreatic cancer by blocking Yap1-Cox2 circuit with statin and aspirin |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP230144 |
| Date: | 2023 - 2025 |
| Title: | Institutional Research Grant (IRG) UT MDACC AI Aided Molecular Imaging for Interrogating Early Detection and Early Therapeutic Efficacy in Alzheimer’s Disease |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2022 - 2027 |
| Title: | Metabolic Biomarkers for Immunotherapy Resistance in Melanoma |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA276219 |
| Date: | 2022 - 2024 |
| Title: | Enzalutamide Pretreatment Sensitizes Prostate Cancer to Metabolic Inhibitors |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | TBD R21 |
| Date: | 2022 - 2025 |
| Title: | Targeted Hyperpolarized Molecular Beacons for Colorectal Cancer Detection |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | FP14699 |
| Date: | 2022 - 2025 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | FP00014979 |
| Date: | 2022 - 2025 |
| Title: | Glutaminase inhibitors enhance sensitivity of castrate resistant prostate cancer to anti-androgen therapy |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| ID: | PC210339 |
| Date: | 2022 - 2024 |
| Title: | Metabolic Evolution of Glioblastoma by Hyperpolarized MRI and Artificial Intelligence (AI) |
| Funding Source: | Ben and Catherine Ivy Foundation |
| Role: | PI |
| ID: | N/A |
| Date: | 2022 - 2024 |
| Title: | Metabolic Evolution of Glioblastoma by Hyperpolarized MRI and Artificial Intelligence (AI) |
| Funding Source: | The Fund for Innovation in Cancer Informatics |
| Role: | PI |
| ID: | N/A |
| Date: | 2022 - 2027 |
| Title: | Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| ID: | 2T32CA196561-06 |
| Date: | 2022 - 2027 |
| Title: | Early Detection of Pancreatic Cancer by Interrogating the Metabolic Evolution of PanIN by MRI and Artificial Intelligence (AI) |
| Funding Source: | NIH |
| Role: | PI |
| ID: | R01CA269506 |
| Date: | 2022 - 2025 |
| Title: | Detection and Assessment of Ovarian Cancer Aggressiveness by Metabolic Imaging: Pilot Study |
| Funding Source: | QIAC Partnership in Research Program Pilot Research Proposal Award |
| Role: | PI |
| Date: | 2022 - 2025 |
| Title: | Developing Imaging Biomarkers for Immunotherapy Resistance In Vivo |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP220270 |
| Date: | 2022 - 2025 |
| Title: | Imaging Metabolic Reprogramming in Prostate Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP220313 |
| Date: | 2022 - 2026 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP220396 |
| Date: | 2022 - 2025 |
| Title: | Interrogating the Metabolic Evolution of Glioblastoma by Hyperpolarized MRI and Artificial Intelligence (AI) |
| Funding Source: | UT Health Science Center – Houston / Cancer Prevention and Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Date: | 2022 - 2025 |
| Title: | Interrogating the Metabolic Evolution of Glioblastoma by Hyperpolarized MRI and Artificial Intelligence (AI) |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | R-22.1-IIRACSBC |
| Date: | 2022 - 2024 |
| Title: | MRI-based Virtual Colonoscopy by Hyperpolarized Silicon Particles |
| Funding Source: | Prevent Cancer Foundation |
| Role: | PI |
| ID: | N/A |
| Date: | 2021 - 2023 |
| Title: | Interrogating the Metabolic Evolution of Glioblastoma by MRI and AI |
| Funding Source: | Emerson Collective Cancer Research Fund |
| Role: | PI |
| Date: | 2021 - 2024 |
| Title: | Studies to Evaluate the Role of Metabolic Reprogramming in Racial Disparities of Castrate Resistant Prostate Cancer |
| Funding Source: | Icahn School of Medicine at Mount Sinai / Department of Defense |
| Role: | Co-PI |
| ID: | PC200695 |
| Date: | 2021 - 2024 |
| Title: | Targeted Hyperpolarized Molecular Beacons for Colorectal Cancer Detection |
| Funding Source: | NIH/NIBIB |
| Role: | PI |
| ID: | R21EB031217-01A1 |
| Date: | 2021 - 2024 |
| Title: | Evaluation of Real-time Metabolic Imaging Biomarkers for Detection of Pancreatic Premalignant Lesions |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 75N91019D00021 |
| Date: | 2021 - 2024 |
| Title: | Identifying Different Metabolic Sub-types of Prostate Cancer for Early Therapeutic Assessment |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | PC200641 |
| Date: | 2021 - 2026 |
| Title: | Imaging Biomarkers for Immunotherapy Resistance in Melanoma In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA258437 |
| Date: | 2021 - 2026 |
| Title: | Targeting Resistance to Enzalutamide Therapy in Different Metabolic Sub-types of Prostate Cancer |
| Funding Source: | NIH |
| Role: | PI |
| ID: | FP00012250 |
| Date: | 2021 - 2021 |
| Title: | Employing Artificial Intelligence (AI) and Hyperpolarized MRI to Inform Metabolic Evolution of Glioblastoma |
| Funding Source: | B*Cured |
| Role: | PI |
| Date: | 2021 - 2023 |
| Title: | Imaging Biomarkers for Immunotherapy Resistance in Melanoma In Vivo |
| Funding Source: | Melanoma Research Alliance |
| Role: | PI |
| Date: | 2021 - 2024 |
| Title: | Real-time Metabolic Imaging Biomarkers for Detection of Pancreatic Premalignant Lesions |
| Funding Source: | Duncan Family Institute for Cancer Prevention and Risk Assessment Seed-funding Research Program |
| Role: | PI |
| ID: | N/A |
| Date: | 2021 - 2024 |
| Title: | Hyperpolarized Molecular Beacons for Colorectal Cancer Detection |
| Funding Source: | Welch Foundation |
| Role: | PI |
| Date: | 2021 - 2022 |
| Title: | Development of Platelet-based Metabolic Biomarkers for Ovarian Cancer |
| Funding Source: | Kaleidoscope of Hope (KOH) Ovarian Cancer Foundation Research Grant |
| Role: | PI |
| ID: | FP00012415 |
| Date: | 2021 - 2024 |
| Title: | Hyperpolarized MRI and metabolomics for metabolic sub-typing of prostate cancer |
| Funding Source: | The University of Texas MD Anderson Cancer Center Quantitative Imaging Analysis Core (QIAC) |
| Role: | Co-Research Investigator |
| ID: | N/A |
| Date: | 2021 - 2026 |
| Title: | Cyclic Peptides for the Inhibition of Autophagy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA258650-01 |
| Date: | 2021 - 2023 |
| Title: | Pilot Study Award |
| Funding Source: | Rivkin |
| Role: | PI |
| ID: | FP00012610 |
| Date: | 2021 - 2026 |
| Title: | Imaging Biomarkers for Immunotherapy Resistance in Melanoma In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA258437-01A1 |
| Date: | 2021 - 2025 |
| Title: | Hyperpolarized Silicon Nanoparticles for Targeted Molecular Imaging Applications |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | CA257838-01 |
| Date: | 2021 - 2024 |
| Title: | Targeted Hyperpolarized Molecular Beacons for Colorectal Cancer Detection |
| Funding Source: | NIH/NIBIB |
| Role: | PI |
| ID: | R21EB031217-01 |
| Date: | 2021 - 2024 |
| Title: | Development of Silicon Nanoparticles as Molecular Beacons for Targeted Molecular Imaging |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2021 - 2021 |
| Title: | Overcoming ADT Resistance in Metastatic Castration Resistance Prostate Cancer (mCRPC) By Targeting Monocarboxylate Transporter (MCT) Pathway |
| Funding Source: | Mike Slive Foundation |
| Role: | PI |
| ID: | FP00012415 |
| Date: | 2020 - 2025 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA244415-01A1 |
| Date: | 2020 - 2025 |
| Title: | Imaging biomarkers for early detection and prevention of pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2020 - 2021 |
| Title: | Hyperpolarized MRI and Artificial Intelligence (AI) to Inform Metabolic Evolution of Glioblastoma Throughout Tumor Progression |
| Funding Source: | NIH/NCI/The University of Texas MD Anderson Cancer Center – Brain SPORE DRP |
| Role: | PI |
| Date: | 2020 - 2023 |
| Title: | Prostate cancer tryptophan metabolism alters the immune microenvironment and promotes aggressive variant phenotype |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| ID: | PC190355 |
| Date: | 2020 - 2022 |
| Title: | Employing Artificial Intelligence (AI) and Hyperpolarized MRI to Inform Metabolic Evolution of Glioblastoma Throughout Tumor Progression to the Point of Relapse |
| Funding Source: | Gulf Coast Consortia |
| Role: | PI |
| Date: | 2020 - 2025 |
| Title: | Hyperpolarized MR-Based Molecular Imaging for Early Detection of Precancerous and Cancerous Colorectal Lesions |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1-R01-CA255005-01 |
| Date: | 2020 - 2022 |
| Title: | Development of Blood-based Metabolic Biomarkers for Ovarian Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | OC190320 |
| Date: | 2020 - 2023 |
| Title: | Hyperpolarized MR based molecular imaging for early detection of precancerous and cancerous colorectal cancer lesions |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator-MDACC |
| ID: | CA190348P1 |
| Date: | 2020 - 2025 |
| Title: | Multi-modal Imaging for the Prevention of Liver Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| Date: | 2020 - 2025 |
| Title: | Monitoring Therapeutic Intervention in Alcoholic Hepatitis by Multi-modal Imaging |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01AA028880-01 |
| Date: | 2020 - 2025 |
| Title: | Imaging Biomarkers for Immunotherapy Resistance in Melanoma In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA251199 |
| Date: | 2020 - 2025 |
| Title: | Diagnosis and Monitoring of Inflammation and Cell Death in NASH Using PET/CT |
| Funding Source: | NIH/NIDDK |
| Role: | Co-I |
| ID: | R01DK125518 |
| Date: | 2020 - 2023 |
| Title: | Development of Hyperpolarized Molecular Beacons for Colorectal Cancer Detection |
| Funding Source: | NIH/NIBIB |
| Role: | PI |
| ID: | R21EB030073 |
| Date: | 2020 - 2021 |
| Title: | Early Detection of Pancreatic Cancer in High Risk Patients by Hyperpolarized Metabolic MRI |
| Funding Source: | The University of Texas MD Anderson Cancer Center/CABI |
| Role: | PI |
| Date: | 2020 - 2023 |
| Title: | Hyperpolarized Metabolic Beacons for Colorectal Cancer Detection |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA248096-01 |
| Date: | 2020 - 2023 |
| Title: | Imaging Biomarkers for Immunotherapy Resistance in Melanoma In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2020 - 2022 |
| Title: | Real-time imaging of immunotherapy resistance in melanoma |
| Funding Source: | Emerson Collective |
| Role: | PI |
| Date: | 2020 - 2023 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP200366 |
| Date: | 2020 - 2022 |
| Title: | Targeted Hyperpolarized Molecular Beacons for Colorectal Cancer Detection |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | CA190441 |
| Date: | 2020 - 2021 |
| Title: | Mark-III 129Xe Gas Polarizer System |
| Funding Source: | NIH/NCI |
| Role: | Minor User |
| ID: | 1S10OD027038-01A1 |
| Date: | 2020 - 2021 |
| Title: | Developing Biomarkers to Image Immunotherapy Resistance in Melanoma in Real-time |
| Funding Source: | Elsa U Pardee Foundation |
| Role: | PI |
| Date: | 2020 - 2020 |
| Title: | Hyperpolarized Metabolic Fingerprinting of Prostate Cancer |
| Funding Source: | The Mike Slive Foundation for Prostate Cancer Research |
| Role: | PI |
| Date: | 2019 - 2022 |
| Title: | Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA244415-01 |
| Date: | 2019 - 2021 |
| Title: | “Spin Batteries” for Imaging Biochemical Reactions in Cancer Systems In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R21CA236643-01A1 |
| Date: | 2019 - 2024 |
| Title: | Cell surface biomarker-based hyperpolarized MRI for early detection of colorectal cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| Date: | 2019 - 2021 |
| Title: | Early Detection of Colorectal Cancer by Hyperpolarized Silicon MRI based Molecular Imaging |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | CA180278 |
| Date: | 2019 - 2020 |
| Title: | Metabolic Imaging of Therapeutic Efficacy in Glioblastoma by Hyperpolarized Magnetic Resonance |
| Funding Source: | NIH/NCI/The University of Texas MD Anderson Cancer Center - Developmental Research Program |
| Role: | DRP Principal Investigator |
| ID: | P50CA127001 |
| Date: | 2019 - 2024 |
| Title: | MD Anderson Cancer Center SPORE in Gastrointestinal Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1P50CA221707 |
| Date: | 2019 - 2024 |
| Title: | Cell Surface Biomarker Based Hyperpolarized MRI for Early Detection of Colorectal Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2019 - 2021 |
| Title: | Silicon MRI Based Virtual Colonoscopy |
| Funding Source: | American Society for Gastrointestinal Endoscopy |
| Role: | PI |
| Date: | 2019 - 2020 |
| Title: | Development of Platelet-based Metabolic Biomarkers for Ovarian Cancer |
| Funding Source: | Rivkin Center |
| Role: | PI |
| Date: | 2019 - 2021 |
| Title: | Targeted Hyperpolarized Silicon Beacons for Colorectal Cancer Detection |
| Funding Source: | NIH/NIBIB |
| Role: | PI |
| ID: | 1 R21 EB027884-01 |
| Date: | 2019 - 2024 |
| Title: | Measuring Extracellular pH in Pre-clinical Tumor Models with acidoCEST MRI |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1-R01-CA236870-01 |
| Date: | 2019 - 2022 |
| Title: | The Antitumor Effect of Mistletoe in Hepatocellular Carcinoma vial Downregulation of myc Signaling and Metabolism |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP190396 |
| Date: | 2019 - 2022 |
| Title: | Early Detection of Colorectal Cancer by Hyperpolarized Silicon Particles |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP190367 |
| Date: | 2019 - 2022 |
| Title: | “Spin Batteries” for Imaging Biochemical Reactions in Cancer Systems In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 R21 CA236643 01 |
| Date: | 2019 - 2022 |
| Title: | Devising Effective Treatment for PDAC by Co-targeting Tumor Cells and the Tumor Microenvironment |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP190026 |
| Date: | 2018 - 2020 |
| Title: | Hyperpolarized Targeted Molecular Imaging of Colorectal Cancer by MRI |
| Funding Source: | The Mark Foundation for Cancer Research |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Early Detection of Pancreatic Cancer by Real-time Metabolic Imaging |
| Funding Source: | Hirshberg Foundation for Pancreatic Cancer Research |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Virtual Colonoscopy for Early Detection of Colorectal Cancer |
| Funding Source: | Colon Cancer Coalition |
| Role: | PI |
| Date: | 2018 - 2022 |
| Title: | Hyperpolarized Silicon Nanoparticle “Spin Batteries” For Imaging Biochemical Reactions in Vivo |
| Funding Source: | The University of Texas MD Anderson Cancer Center – Institutional Research Grant |
| Role: | PI |
| Date: | 2018 - 2021 |
| Title: | Molecular Targeted Magnetic Resonance Reporter for Cancer Detection |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | RP180164 |
| Date: | 2018 - 2023 |
| Title: | Circulating Biomarkers and Imaging for Early Detection of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1 U01 CA214263-01A1 |
| Date: | 2018 - 2023 |
| Title: | Targeting Glucose Metabolism with HJC0152 for Treating Metastatic Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1 R01 CA231150 01 |
| Date: | 2018 - 2023 |
| Title: | Measuring extracellular pH in pre-clinical tumor models with acidoCEST MRI |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA227267-01A1 |
| Date: | 2018 - 2023 |
| Title: | Chemoprevention of Breast Cancer by Targeting Glucose Metabolism with HJC0152 |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 1 R01 CA226001 01 |
| Date: | 2018 - 2022 |
| Title: | Translational Applications in an Animal Model of Pancreatic Cystic Neoplasm and Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1 R01 CA218004-01A1 |
| Date: | 2017 - 2019 |
| Title: | Early Detection of Pancreatic Cancer by Targeted Molecular Imaging of Hyperpolarized Silicon Nanoparticles |
| Funding Source: | Gulf Coast Consortia – Computational Cancer Biology Training Grant |
| Role: | Mentor (no salary support) |
| ID: | RP170593 |
| Date: | 2016 - 2019 |
| Title: | Elimination of hypoxia sensitizes resistant solid tumors to Immunotherapy |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP170399 |
| Date: | 2016 - 2019 |
| Title: | Early Assessment of Ovarian Cancer Aggressiveness and Therapeutic Efficacy by Real-Time Hyperpolarized Metabolic Imaging |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | OC150496 |
| Date: | 2016 - 2024 |
| Title: | Metabolic Imaging of Prostate Cancer Patients for Monitoring Therapeutic Efficacy |
| Funding Source: | GE Healthcare/Center for Advanced Biomedical Imaging |
| Role: | Co-PI |
| ID: | WS #28 |
| Date: | 2016 - 2018 |
| Title: | Early Detection of PanIN By Hyperpolarized Metabolic MR Imaging |
| Funding Source: | Pancreatic Cancer Action Network - Translational Research Grant |
| Role: | PI |
| ID: | 16-65-BHAT |
| Date: | 2016 - 2018 |
| Title: | Understanding the Heterogeneity of Gliomas: Image-Guided biopsy Correlations to Pathology, Metabolomics, Proteomics and Genomics |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2016 - 2020 |
| Title: | The therapeutic effect of mistletoe on hepatocellular carcinoma by targeting cMyc |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2016 - 2021 |
| Title: | Multi-Target Epitope Vaccine Platform for Personalized Cancer Immunotherapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA207302-01 |
| Date: | 2016 - 2024 |
| Title: | Neuroimaging in Cancer Care |
| Funding Source: | NIH/NINDS |
| Role: | Co-I |
| Date: | 2016 - 2020 |
| Title: | Real-time Targeted Molecular Imaging of Cancer by Hyperpolarization |
| Funding Source: | American Cancer Society (ACS) |
| Role: | PI |
| ID: | 367089 |
| Date: | 2016 - 2019 |
| Title: | The Antitumor Effect of Mistletoe in Hepatocellular Carcinoma via Down Regulation of Myc Signaling and Metabolism |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | PP160045 |
| Date: | 2016 - 2019 |
| Title: | Hyperpolarized Metabolic Imaging of Prostate Cancer for Risk Stratification and Surveillance |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP160359 |
| Date: | 2016 - 2019 |
| Title: | Targeted Molecular Imaging of Cell Death in Ovarian Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R21CA181994-02A1 |
| Date: | 2016 - 2016 |
| Title: | TMC-GCC Collaborative Symposium: Metabolism in Cancer |
| Funding Source: | John S. Dunn Collaborative Research award Program |
| Role: | PI |
| Date: | 2015 - 2021 |
| Title: | Functional Imaging and Prostate Cancer |
| Funding Source: | The University of Texas MD Anderson Cancer Center Philanthropy |
| Role: | Co-PI |
| Date: | 2015 - 2016 |
| Title: | Brain Tumor SPORE Development Research Project |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2015 - 2016 |
| Title: | Hyperpolarized Metabolic Imaging of Brain Cancer Therapy to Predict Outcome |
| Funding Source: | NCI SPORE |
| Role: | PI |
| Date: | 2015 - 2020 |
| Title: | Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| ID: | 1T32CA196561-04 |
| Date: | 2015 - 2017 |
| Title: | Early assessment of ovarian cancer aggressiveness and therapeutic efficacy by real-time hyperpolarized metabolic imaging |
| Funding Source: | Institutional Research Grant Program (IRG) |
| Role: | PI |
| Date: | 2015 - 2016 |
| Title: | Non-invasive Assessment of Ovarian Cancer Aggressiveness Using Real-time Hyperpolarized Metabolic Imaging |
| Funding Source: | Sprint for Life Research Award |
| Role: | PI |
| Date: | 2015 - 2017 |
| Title: | Non-invasive Colonoscopy by Molecular Imaging of Mucin Targeted Hyperpolarized Silicon Nanoparticles |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP 150701 |
| Date: | 2014 - 2017 |
| Title: | Inhibiting Oxidative Phosphorylation: A Novel Strategy in Leukemia |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP 140218 |
| Date: | 2014 - 2015 |
| Title: | Metabolic Imaging of N-acetylaspartate Pathway in Ovarian Cancer |
| Funding Source: | HERA Women's Cancer Foundation |
| Role: | PI |
| Date: | 2014 - 2017 |
| Title: | Therapeutic Targeting of Glioblastoma |
| Funding Source: | MD Anderson Brain Tumor Moonshot Award |
| Role: | Co-I |
| Date: | 2014 - 2016 |
| Title: | Early Detection of Pancreatic Cancer In Vivo by Molecular Imaging of Lactose-functionalized Silicon Nanoparticles and Hyperpolarized Magnetic Resonance |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2014 - 2014 |
| Title: | Real-time pH Imaging in Cancer In Vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2014 - 2014 |
| Title: | Early Detection of Colon Cancer by Targeted Hyperpolarized Silicon Nanoparticles |
| Funding Source: | John S. Dunn Foundation |
| Role: | PI |
| Date: | 2013 - 2015 |
| Title: | Metabolic Profiling of Core Biopsies for Finasteride Exposed and Unexposed Early Stage Prosate Cancer |
| Funding Source: | Prostate Cancer Research Program |
| Role: | PI |
| Date: | 2013 - 2014 |
| Title: | Knowledge Gap in Moonshot Award |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | Co-I |
| ID: | N/A |
| Date: | 2013 - 2014 |
| Title: | Real-time Metabolic Imaging of Leukemia By Hyperpolarization |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2013 - 2014 |
| Title: | Institutional Research Grant (IRG) UT MDACC High Definition Non-invasive MR Colonoscopy by Hyperpolarized Silicon Nanoparticles |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2012 - 2013 |
| Title: | Personalized X-aptamer-nanoparticle therapeutics for ovarian or melanoma cancers and a novel detection mechanism |
| Funding Source: | UTMDACC and UTHSCH |
| Role: | Co-I |
| ID: | Contract |
| Date: | 2012 - 2016 |
| Title: | Prostate Cancer Research Program Idea (PCRP-DoD) |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| ID: | Grant Number |
| Date: | 2012 - 2024 |
| Title: | Institutional Startup Research Funding |
| Funding Source: | The University of Texas MD Anderson Cancer Center Cancer System Imaging Department |
| Role: | PI |
| Date: | 2008 - 2010 |
| Title: | PASADENA: Molecular Imaging of Angiogenesis In Vivo |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| Date: | 2007 - 2012 |
| Title: | Ultra-fast Nitrogen 15 Imaging of Choline in Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | R01 CA122513-01 |
| Date: | 2007 - 2011 |
| Title: | Fold Signal Enhancement for Imaging Vulnerable Plaque |
| Funding Source: | Tobacco-Related Disease Research Program |
| Role: | PI |
| Date: | 2006 - 2008 |
| Title: | PASADENA: Ultra-fast Carbon 13 Imaging for Early Diagnosis of Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R21 RCA118509A |
| Date: | 2006 - 2008 |
| Title: | Neuroprotection by VEGF after stroke: Real-time Hyperpolarized 13C Molecular Imaging and Spectroscopy In Vivo |
| Funding Source: | American Heart Association |
| Role: | PI |
| Date: | 2006 - 2008 |
| Title: | Ultra-fast Carbon 13 Imaging and Spectroscopy for Early Diagnosis of Brain Tumor in Rodents |
| Funding Source: | American Brain Tumor Association |
| Role: | PI |
| Date: | 2004 - 2006 |
| Title: | Jams G. Boswell Fellowship |
| Funding Source: | James G. Boswell Fellowship |
| Role: | Postdoctoral Fellow |
| Date: | 2003 - 2009 |
| Title: | PASADENA: Molecular Imaging of Angiogenesis In Vivo |
| Funding Source: | Rudi Schulte Research Institute |
| Role: | Co-PI |
| Title: | Pilot Grant |
| Funding Source: | TMC DDC - Texas Medical Center Digestive Diseases Center |
| Role: | PI |
| ID: | FP00012287 |
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CV information above last modified March 31, 2025