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Richard Robert Bouchard, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Imaging Physics - Research, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Regular Member, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX

Research Interests

Today’s healthcare climate calls for medical technology that provides a safe, inexpensive, patient-specific, and point-of care diagnostic and therapeutic solution.  Ultrasound-mediated imaging technologies, such as photoacoustic (PA) or elasticity imaging, allow clinicians to probe a patient’s specific molecular composition, permit assessment of tissue viscoelasticity, or afford unprecedented contrast for real-time image-guided therapy.  Ultrasound-mediated imaging solutions can be provided at a price point, convenience, and operating ease that permits bedside utilization or straightforward intraoperative integration. Consequently, I have focused my research program on clinical photoacoustic-ultrasonic (PAUS) and acoustic radiation force (ARF)-based elasticity imaging technologies. I have targeted prostatic and cardiac diseases because of their high incidence in the United States and the reasonable access one can achieve to these organs with transrectal or intracardiac imaging transducers. Specifically, I am investigating novel uses of PAUS and (ARF)-based imaging in the detection, assessment, and treatment of cancer and cardiac disease. Although my primary research focus is the development of clinical techniques, I have also invested considerable effort in preclinical (i.e., murine model) PAUS imaging of molecular (i.e., nanoscale) theranostic probes, some of which share translational relevance with the aforementioned clinical applications.

Office Address

The University of Texas MD Anderson Cancer Center
1881 East Road
Unit Number: 1902
Houston, TX 77054
Room Number: 3SCR2.3614
Email: rrbouchard@mdanderson.org

Education & Training

Degree-Granting Education

2010 Duke University, Pratt School of Engineering, Durham, NC, PHD, Biomedical Engineering
2004 Duke University, Pratt School of Engineering, Durham, NC, BSE, Biomedical Engineering, Electrical Engineering, and Cultural Anthropology

Experience/Service

Academic Appointments

Instructor, Department of Imaging Physics - Research, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012-2013
Visiting Scholar, Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 2011-2013
Postdoctoral Fellow, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-2012
Whitaker International Fellow, Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, Netherlands, 2006-2007
Research Assistant, Duke University, Durham, NC, 2004-2010

Honors and Awards

2011-2012 Odyssey Fellowship, The University of Texas M D Anderson Cancer Center
2006-2007 Whitaker International Fellowship
2004-2009 James B. Duke Graduate Fellowship, Duke University
2004-2008 National Science Foundation Graduate Fellowship
2004-2005 Pratt-Gardner Fellowship, Duke University
2003 Phi Beta Kappa Honor Society

Selected Publications

Peer-Reviewed Original Research Articles

1. Dana N, Di Biase L, Natale A, Emelianov SY, Bouchard RR. In-vitro Photoacoustic Visualization of Myocardial Ablation Lesions. Heart Rhythm 11(1), 2014. PMID: 24080065.
2. Bouchard RR, Sahin O, Emelianov SY. Ultrasound-guided Photoacoustic Imaging: current state and future development. IEEE Trans Ultrason Ferroelectr Freq Control 61(3):450-466, 2014. PMID: 24569250.
3. Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM. Fluorinated graphene oxide; a new multimodal material for biological applications. Adv Mater 25(39):5632-7, 10/2013. e-Pub 8/2013. PMID: 24038195.
4. Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace M, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Control Release 172(1). e-Pub 8/2013. PMID: 23920038.
5. Candelaria RP, Hwang L, Bouchard RR, Whitman GJ. Ultrasound and Breast Cancer: Diagnosis, Staging, and Biopsy. Semin Ultrasound CT MR 3(34):213-225, 6/2013. PMID: 23768888.
6. Mitcham T, Homan K, Frey W, Chen YS, Emelianov S, Hazle J, Bouchard R. Modulation of Photoacoustic Signal Generation from Metallic Surfaces. J Biomed Opt 18(5):56008, 5/2013. PMCID: PMC3646486.
7. Hsu SJ, Byram BC, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. Acoustic radiation force impulse imaging of mechanical stiffness propagation in myocardial tissue. Ultrason Imaging 34(3):142-58, 7/2012. PMCID: PMC3500656.
8. Cook JR, Bouchard RR, Emelianov SY. Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging. Biomed Opt Express 2(11):3193-206, 11/2011. e-Pub 10/2011. PMCID: PMC3207386.
9. Su JL, Bouchard RR, Karpiouk AB, Hazle JD, Emelianov SY. Photoacoustic imaging of prostate brachytherapy seeds. Biomed Opt Express 2(8):2243-54, 8/2011. e-Pub 7/2011. PMCID: PMC3149522.
10. Bouchard RR, Hsu SJ, Palmeri ML, Rouze NC, Nightingale KR, Trahey GE. Acoustic radiation force-driven assessment of myocardial elasticity using the displacement ratio rate (DRR) method. Ultrasound Med Biol 37(7):1087-100, 7/2011. e-Pub 6/2011. PMCID: PMC3118908.
11. Bouchard RR, Palmeri ML, Pinton GF, Trahey GE, Streeter JE, Dayton PA. Optical tracking of acoustic radiation force impulse-induced dynamics in a tissue-mimicking phantom. J Acoust Soc Am 126(5):2733-45, 11/2009. PMCID: PMC2787080.
12. Bouchard RR, Hsu SJ, Wolf PD, Trahey GE. In vivo cardiac, acoustic-radiation-force-driven, shear wave velocimetry. Ultrason Imaging 31(3):201-13, 7/2009. PMCID: PMC2797484.
13. Hsu SJ, Bouchard RR, Dumont DM, Ong CW, Wolf PD, Trahey GE. Novel acoustic radiation force impulse imaging methods for visualization of rapidly moving tissue. Ultrason Imaging 31(3):183-200, 7/2009. PMCID: PMC2810973.
14. Bouchard RR, Dahl JJ, Hsu SJ, Palmeri ML, Trahey GE. Image quality, tissue heating, and frame rate trade-offs in acoustic radiation force impulse imaging. IEEE Trans Ultrason Ferroelectr Freq Control 56(1):63-76, 1/2009. PMCID: PMC3764610.
15. Bouchard RR, Van Soest G, Trahey GE, Van Der Steen AF. Optical tracking of superficial dynamics from an acoustic radiation force-induced excitation. Ultrason Imaging 31(1):17-30, 1/2009. PMID: 19507680.
16. Zhai L, Palmeri ML, Bouchard RR, Nightingale RW, Nightingale KR. An integrated indenter-ARFI imaging system for tissue stiffness quantification. Ultrason Imaging 30(2):95-111, 4/2008. PMCID: PMC2577389.
17. Hsu SJ, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. In vivo assessment of myocardial stiffness with acoustic radiation force impulse imaging. Ultrasound Med Biol 33(11):1706-19, 11/2007. e-Pub 8/15/2007. PMCID: PMC2117626.
18. Palmeri ML, Sharma AC, Bouchard RR, Nightingale RW, Nightingale KR. A finite-element method model of soft tissue response to impulsive acoustic radiation force. IEEE Trans Ultrason Ferroelectr Freq Control 52(10):1699-712, 10/2005. PMCID: PMC2818996.

Book Chapters

1. Bouchard RR, Luke GP, Emelianov SY. Photoacoustic Imaging. In: Ultrasonic Imaging and Therapy. Taylor & Francis: Boca Ranton. In Press.
2. Rosenzweig S, Bouchard R, Polascik T, Zhai L, Nightingale K. Prostate Elastography and Photoacoustic Imaging. In: Image-Guided Prostate Cancer Treatments. Springer: Heidelberg, 2014.
3. Aglyamov S, Bouchard RR, Graf IM, Emelianov SY. Breast Elasticity Imaging. In: Physics of Mammographic Imaging. Taylor & Franics: Boca Ranton, 2012.

Grant & Contract Support

Title: Photoacoustic and Ultrasonic-Image Guided Needle Biopsy of the Prostate
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 2/1/2014 - 1/31/2015

Last updated: 2/26/2014