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Robert S. Bresalier, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: Unit 1466
Houston, TX 77030-4009
Phone: 713-745-4340
Fax: 713-745-9295

Education & Training

Degree-Granting Education

1978 University of Chicago, Chicago, IL, MD, Medicine
1973 State University of New York at Stonybrook, Stonybrook, NY, BS, (Honors), Biological Sciences

Postgraduate Training

7/1981-6/1984 Fellowship, Gastroenterology, University of California, San Francisco, San Francisco, CA
7/1978-6/1981 Residency, Internal Medicine, Barnes Hospital, Washington University, St. Louis, MO

Board Certifications

1983 American Board of Internal Medicine, Gastroenterology
1981 American Board of Internal Medicine, Internal Medicine

Experience/Service

Endowed Positions

Birdie J. and Lydia J. Resoft Distinguished Professor in Gastrointestinal Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2003-present

Honors and Awards

2014-present Department of Veterans Affairs Oncology C Merit Review Study Section, Department of Veterans Affairs
2009-present ZCA1 SRLB-R the NCI, ARRA Grand Opportunities - Molecular Targets and Cancer Genomics, Special Emphasis Panel, NCI, ARRA
2008-present ZCA1 SRB-Y Colon Cancer Family Registry: Selected Member, Special Review Group, NIH
2008-present ZDK1 GRB-N R13 Conference Grant Applications Special Review Group, NIH
2007-2016 ZDK 1GRB-N (M1) Extramural Loan Repayment Program Selected Member Special Review Group, NIH
2003-present Birdie J and Lydia J Resoft Distinguished Professor in Gastrointestinal Oncology, University of Texas MD Anderson Cancer Center

Professional Memberships

Alpha Omega Alpha National Medical Honor Society
Member, 1997-present
American Association for Cancer Research
Member, 1983-present
American Association for Cancer Research Taskforce on Cancer Prevention
Member, 2005-present
American College of Physicians
Fellow, 1981-present
American Federation for Clinical Research
Member, 1981-present
American Gastroenterological Association
Member, 1981-present
American Medical Association
Member, 1974-present
American Society for Gastrointestinal Endoscopy
Member, 1981-present
Colon Cancer Screening Guidelines Committee, Houston, TX
Chair, 2009-present
Faculty Senate, Houston, TX
Member, 2007-present
Gastrointestinal Oncology Section
Member, Abstract Selection Committee, 2011-present
International Metastasis Research Society
Member, 1986-present
International Society of Gastrointestinal Oncology
Scientific Advisory, Board, 2003-present
National Foundation for Ileitis and Colitis
Member, 1981-present
OMED, Steering Committee for Colorectal Cancer Screening, 2006
Executive Committee, 2006-present
Research Committee of the Faculty Senate, Houston, TX
Member, 2007-present
Review Committee, Houston, TX
Member, 2014-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Raju G, Lum P, Ross W, Thirumurthi S, Miller E, Lynch P, Lee J, Bhutani M, Shafi M, Weston B, Pande M, Bresalier R, Rashid A, Mishra L, Davila M, Stroehlein J. Outcome of Endoscopic Mucosal Resection As an Alternative to Surgery in Patients with Complex Colon Polyps. Gastrointest Endosc. e-Pub 2/6/2016. PMID: 26859866.
2. Raju GS, Lum PJ, Slack RS, Thirumurthi S, Lynch PM, Miller E, Weston BR, Davila ML, Bhutani MS, Shafi MA, Bresalier RS, Dekovich AA, Lee JH, Guha S, Pande M, Blechacz B, Rashid A, Routbort M, Shuttlesworth G, Mishra L, Stroehlein JR, Ross WA. Natural language processing as an alternative to manual reporting of colonoscopy quality metrics. Gastrointest Endosc. e-Pub 4/22/2015. PMID: 25910665.
3. Bresalier RS, Kopetz S, Brenner DE. Blood-based tests for colorectal cancer screening: do they threaten the survival of the FIT test? Dig Dis Sci 60(3):664-71, 3/2015. e-Pub 2/14/2015. PMID: 25680874.
4. Bresalier RS. Flexible sigmoidoscopy: more than a unilateral breast exam? Dig Dis Sci 60(3):634-8, 3/2015. PMID: 25740557.
5. Thosani N, Rao B, Batra S, Adeyefa B, Raju GS, Bresalier RS, Banerjee S, Guha S. Diagnostic yield of third eye retroscope on adenoma detection during colonoscopy: A systematic review and meta-analysis. World Journal of Meta-Analysis 2(4):162-170, 11/2014.
6. Barry EL, Rees JR, Peacock JL, Mott LA, Amos CI, Bostick RM, Figueiredo JC, Ahnen DJ, Bresalier RS, Burke CA, Baron JA. Genetic Variants in CYP2R1, CYP24A1 and VDR Modify the Efficacy of Vitamin D3 Supplementation for Increasing Serum 25-Hydroxyvitamin D Levels in a Randomized Controlled Trial. J Clin Endocrinol Metab. e-Pub 7/29/2014. PMID: 25070320.
7. Kim SJ, Lee HW, Gu Kang H, La SH, Choi IJ, Ro JY, Bresalier RS, Song J, Chun KH. Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress. Cell Death Differ. e-Pub 6/27/2014. PMID: 24971481.
8. Kim SJ, Wang YG, Lee HW, Kang HG, La SH, Choi IJ, Irimura T, Ro JY, Bresalier RS, Chun KH. Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer. Oncotarget 5(10):3386-98, 5/30/2014. PMCID: PMC4102817.
9. Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, Hitchler MJ, Yan C, Schumacher FR, Conti DV, Edlund CK, Noushmehr H, Coetzee SG, Bresalier RS, Ahnen DJ, Barry EL, Berman BP, Rice JC, Coetzee GA, Casey G. Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1. Hum Mol Genet 23(8):2198-209, 4/15/2014. e-Pub 11/20/2013. PMCID: PMC3959808.
10. Barry EL, Mott LA, Melamed ML, Rees JR, Ivanova A, Sandler RS, Ahnen DJ, Bresalier RS, Summers RW, Bostick RM, Baron JA. Calcium supplementation increases blood creatinine concentration in a randomized controlled trial. PLoS One 9(10):e108094, 2014. e-Pub 10/15/2014. PMCID: PMC4198086.
11. Fortini BK, Tring S, Plummer SJ, Edlund CK, Moreno V, Bresalier RS, Barry EL, Church TR, Figueiredo JC, Casey G. Multiple Functional Risk Variants in a SMAD7 Enhancer Implicate a Colorectal Cancer Risk Haplotype. PLoS One 9(11):e111914, 2014. e-Pub 11/6/2014. PMCID: PMC4223076.
12. Rees JR, Hendricks K, Barry EL, Peacock JL, Mott LA, Sandler RS, Bresalier RS, Goodman M, Bostick RM, Baron JA. Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. Clin Infect Dis 57(10):1384-92, 11/2013. e-Pub 9/6/2013. PMCID: PMC3805175.
13. Turner ND, Ritchie LE, Bresalier RS, Chapkin RS. The microbiome and colorectal neoplasia: environmental modifiers of dysbiosis. Curr Gastroenterol Rep 15(9):346, 9/2013. PMCID: PMC3807587.
14. Raju GS, Vadyala V, Slack R, Krishna SG, Ross WA, Lynch PM, Bresalier RS, Hawk E, Stroehlein JR. Adenoma detection in patients undergoing a comprehensive colonoscopy screening. Cancer Med 2(3):391-402, 6/2013. e-Pub 4/20/2013. PMCID: PMC3699850.
15. Barry EL, Poole EM, Baron JA, Makar KW, Mott LA, Sandler RS, Ahnen DJ, Bresalier RS, McKeown-Eyssen GE, Ulrich CM. CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment. Cancer Causes Control. e-Pub 10/19/2012. PMID: 23081681.
16. Sung JJ, Ng EK, Lin Jt, Ho KY, Ji JR, Sugano K, Poon RT, Chan AT, Goh KL, Han KH, Chen LL, Wu KC Ng SS, Bresalier RS, Chan FK. Digestive cancer management in Asia: Position statements: A report on GI Oncology Summit in 2011. J Gastroenterol Hepatol 27(9):1417-1422, 9/2012. PMID: 22694174.
17. Laiyemo AO, Doubeni C, Pinsky PF, Doria-Rose VP, Sanderson AK, Bresalier R, Weissfeld J, Schoen RE, Marcus PM, Prorok PC, Berg CD. Factors Associated with Inadequate Colorectal Cancer Screening with Flexible Sigmoidoscopy. Cancer Epidemiol 36(4):395-9, 8/2012. e-Pub 11/22/2011. PMCID: PMC3288883.
18. Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO, Bresalier R, Andriole GL, Buys SS, Crawford ED, Fouad MN, Isaacs C, Johnson CC, Reding DJ, O'Brien B, Carrick DM, Wright P, Riley TL, Purdue MP, Izmirlian G, Kramer BS, Miller AB, Gohagan JK, Prorok PC, Berg CD, PLCO Project Team. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med 366(25):2345-57, 6/21/2012. e-Pub 5/21/2012. PMID: 22612596.
19. Yurgelun MB, Goel A, Hornick JL, Sen A, Turgeon DK, Ruffin MT, Marcon NE, Baron JA, Bresalier RS, Syngal S, Brenner DE, Boland CR, Stoffel EM. Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps. Cancer Prev Res (Phila) 5(4):574-82, 4/2012. e-Pub 1/18/2012. PMID: 22262812.
20. Mazurek N, Byrd JC, Sun Y, Hafley M, Ramirez K, Burks J, Bresalier RS. Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ 19(3):523-33, 3/2012. e-Pub 9/23/2011. PMCID: PMC3246527.
21. Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO, Bresalier RS, Hickey T, Riley T, Prorok PC. Colorectal Cancers not detected by screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Gastrointestinal Endoscopy 75(3):612-20, 3/2012. PMID: 22341106.
22. Weissfeld JL, Schoen RE, Pinsky PF, Bresalier RS, Doria-Rose VP, Laiyemo AO, Church T, Yokochi LA, Yurgalevitch S, Rathmell J, Andriole GL, Buys S, Crawford ED, Fouad M, Isaacs C, Lamerato L, Reding D, Prorok PC, Berg CD, PLCO Project Team. Flexible sigmoidoscopy in the randomized prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial: added yield from a second screening examination. J Natl Cancer Inst 104(4):280-9, 2/22/2012. e-Pub 1/31/2012. PMCID: PMC3283538.
23. Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling. PLoS One 7(8):e42699, 2012. e-Pub 8/10/2012. PMCID: PMC3416861.
24. Mazurek N, Byrd JC, Sun Y, Ueno S, Bresalier RS. A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells. Cancer 117(19):4375-80, 10/2011. e-Pub 3/2011. PMCID: PMC3164935.
25. White WB, Bresalier R, Kaplan AP, Palmer BF, Riddell RH, Lesogor A, Chang W, Keefe DL. Safety and tolerability of the direct renin inhibitor aliskiren in combination with angiotensin receptor blockers and thiazide diuretices: a pooled analysis of clinical experience of 12,942 patients. J Clin Hypertens (Greenwich) 13(7):506-16, 7/2011. PMID: 21762364.
26. Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C, Reding DJ, Greenlee RT, Yokochi LA, Kessel B crawford ED, Church TR, Andriole GL, Weissfeld JL, Fouad MN, Chia D, O'Brien B, Ragard LR, Clapp JD, Rathmell JM, Riley TL, Hartge P, Pinsky PF, Zhu CS, Izmirlian G, Kramer BS, Miller AB, Xu JL, Prorok PC, Gohagan JK, Berg CD; PLCO Project Team. Effect of screening on ovairan cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 305(22):2295-303, 6/2011. PMID: 21642681.

Abstracts

1. Baron JA, Barry EL, Burke CA, Bostick R, Bresalier RS, et. al. A clinical trial of supplementation of vitamin D and calcium for prevention of colorectal neoplasia. Proc Am Assoc Cancer Res, 2014.
2. Weston B, Ross W, Lum P, Thirumurthi S, Miller E, Bhutani M, Blechacz B, Bresalier RS, et. al. Adenoma detection rate (ADR) and serrated adenoma detection rate (Sdr) during screening colonoscopy with and without personal cancer history (Pch) in a teriatry referral cancer center. Gastroenterology, Digestive Diseases Week, 2014.
3. Thirumurthi S, Ross W, Lum P, Weston B, Pande M, Lynch P, Shafi M, Bhutani M, Dekovich A, Lee JH, Davila M, Bresalier RS, et. al. Adenoma detection rate and sessile adenoma detection rate trends with increasing age: a study using natrual language processing computer program. Gstroenterology, Digestive Diseases Week, 2014.
4. Illmer M, Mazurek N, Byrd JC Vykolal J, Bresalier RS. Low surface Gal3 expression in breast cancer cells is associated with chemoresistance, tumorigenesis and decreased overall patient survival. Proc Am Assoc Cancer Res, 2014.
5. Raju GS, Ross W, Lum P, Lynch P, Slack R, Miller E, Weston B, Davila M, Thirumurthi S, Shafi M, Bresalier RS, et. al. Natural language processing (NLP) as an alternative to manual reporting of colonoscopy quality metrics. Gastroenterology, Digestive Diseases Week, 2014.
6. Miller E, Ross W, Thirumurthi S, Weston B, Bhutani M, Blechacz B, Bresalier RS, et. al. Screening colonoscopy quality metrics for males and females across ethnic groups using a natural language processing algorithm. Gastroenterology, Digestive Diseases Week, 2014.
7. Bresalier RS. A circulating ligand for galectin-3 elevated in the serum of individuals with colorectal neoplasia. Texas FreshAIR Academia Industry Roundtable, University of Texas, Austin, 10/2013.
8. Illmer M, Mazurek N, Hafley M, Vykoukal J, Alt E, Byrd JC, Bresalier RS. A TRAIL-resistant subset of cancer initiating stem cells characterized by surface galectin-3. Gastroenterology Digestive Diseases Week, 2013.
9. Joe AK, Schnoll-Sussman F, Bresalier RS, Abrams JA, Hanina Hibshoosh H, Cheung K, Friedman RA, Yang C, Milne G, Liu DD, Bigg AM, Foreman J, Lee S, Tao S, Ahmes SA, Nuugat A, Lightdale CJ. Phase 1b randomized double blinded, placebo-controlled dose escalation study of polyphenon E in patients with Barrett's esophagus. Twellfth Annual International Conference on Frontiers in Cancer Prevention, 2013.
10. Laiyemo A, Izmirlian G, Schoen RE, Pinsky P, Doubeni C, Weissfeld J, Bresalier RS, Church T, Prorok P. The effect of screening on racial disparity in colorectal cancer incidence and mortaility. Gastroenterology, Digestive Diseases Week, 2013.
11. Mazurek N, Byrd JC, Bresalier RS. Cell Surface Expessionof the Anti-Apoptotic B-Galactoside-Binding Protein Galectin-3 is Characteristic of the Stem Cell Phenotype in Colorectal Cancer Cells. Gastroenterology, 2012.
12. Schoen RE, Pinsky P, Weissfeld J, Yokochi LA, Church TR, Laiyemo AO, Bresalier RS, Riley TL, Prorok PC, Berg C. Effect of flexible sigmoidoscopy screening on incidence and mortality from colorectal cancer in the PLCO screening trial. Gastroenterology, 2012.
13. Thosani N, Patel P, Raiyani TV, Raju GS, Bresalier RS, Guha S. Seeing behind the folds - Clinical impact of third eye retroscope on adenoma detection during the colonoscopy: A systematic review and Meta-Analysis. Gastroenterology, 2012.
14. Nguyen D, Tuck M, Sen A, Ruffin MT, Baron JA, Bresalier RS, Marcon NE, McConnell D, Stoffel EM, Syngal S, Brenner DE, Turgeon DK. Sensitivity and specificity of fecal immunochemical and guaiac testing for occult blood in archived frozen stool samples. Gastroenterology, 2012.
15. Bresalier RS, Byrd JC, Mazurek N, Brenner D, Syngal S, Marcon N, Turgeon K, Baron JA. A Circulating Ligand for Galectin-3 Elevated in the Serum of Individuals with Colorectal Neoplasia: Results of a New ELISA Using the EDRN Reference Set. Gastroenterology, 2011.

Book Chapters

1. Byrd JC, Mazurek N, Bresalier RS. Post translational modification of galectin-3 and its role in biological function. In: Klyosov AA and Traber PG Galectins and Disease. Implications for targeted therapeutics. John Wiley and Sons, 158-175, 2012.
2. Boland C and Bresalier R. Colonic polyps and polyposis syndromes. In: Surgery Scientific Principles and Practices, Fifth. Ed(s) Greenfield L, Mulholland K, Zeleneck G. Lippncott: Philadelphia, 2011.

Books (edited and written)

1. Bresalier R, Bhutani M, Eds. Atlas of Gastrointestinal Cancer: A Multidisciplinary Approach to Diagnosis, Staging and Treatment. John Wiley & Sons Ltd: London, 2011. ISBN: 9781405195546.

Grant & Contract Support

Title: Blood-Based Markers for Screening and Early Detection of Colorectal Neoplasia
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 12/1/2015 - 11/30/2018
 
Title: Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication of Barrett's Esophagus by Radiofrequency Ablation
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 10/2015 - 9/2019
 
Title: Clinical Utilities of Salivary ExRNA Biomarkers for Gastric Cancer Detection
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Wong
Duration: 8/1/2015 - 7/31/2016
 
Title: Colorectal Chemoprevention with Calcium and Vitamin D
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Baron
Duration: 9/1/2013 - 8/31/2018

Last updated: 3/23/2016