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Robert S. Bresalier, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
1400 Pressler
Unit Number: Unit 1466
Houston, TX 77030-4009
Room Number: Room FCT13.6008
Phone: 713-745-4340
Fax: 713-745-9295

Education & Training

Degree-Granting Education

1978 University of Chicago, Chicago, IL, MD, Medicine
1973 State University of New York at Stonybrook, Stonybrook, NY, BS, (Honors), Biological Sciences

Postgraduate Training

7/1981-6/1984 Fellowship, Gastroenterology, University of California, San Francisco, San Francisco, CA
7/1978-6/1981 Residency, Internal Medicine, Barnes Hospital, Washington University, St. Louis, MO

Board Certifications

1983 American Board of Internal Medicine, Gastroenterology
1981 American Board of Internal Medicine, Internal Medicine

Experience/Service

Endowed Positions

Birdie J. and Lydia J. Resoft Distinguished Professor in Gastrointestinal Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 9/2003-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Song S, Krishnan K, Liy K, Bresalier RS. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clinical Cancer Research 15(2):622-31, 1/2009.
2. Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS, Burke CA, McKeown-Eyssen GE, Baron JA. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 101(6):432-5, 2009. PMCID: PMC2657096.
3. Song S, Mazurek N, Liu C, Liu K, Bresalier RS. Galectin-3 mediates nuclear β-catenin accumulation and Wnt signaling in human colon cancer cells via regulation of GSK-3β actiity. Cancer Research 69:1343, 2009.
4. Grau MV, Sandler RS, McKeown-Eyssen G, Bresalier RS, Haile RW, Barry EL, Ahnen DJ, Gui J, Summers RW, Baron JA. Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study. J Natl Cancer Inst 101(4):267-76, 2009. PMCID: PMC2644329.
5. Stoffel EM, Turgeon DK, Normolle DP, Tuck MK, Marcon N, Baron JA, Bresalier RS, Arber N, Ruffin M, Syngal S, Brenner DE. Chromoendocopy detects more adenomas than colonoscopy using intensive inspection without dye spraying. Cancer Prevention Research 1:507-13, 12/2008.
6. Baron JA, Sandler RS, Bresalier RS, Lanas A, Morton D, Riddell R, Iverson ER, Demets, DL. Cardiovascular events associated with rofecoxib: Final Analysis of the APPROVe Trial. Lancet 372:1756-64, 11/2008.
7. Stoffel E, Turgeon K, Stockwell D, Zhao L, Normolle D, Bresalier R, Tuck M, Marcon N, Baron J, Ruffin M, Brenner D, Syngal S. Missed adenomas during colonscopic surveillance in individuals with Lynch Syndrome (HNPCC). Cancer Prevention Research 1:470-5, 11/2008.
8. Figueiredo J, Levine J, Grau M, Barry E, Ueland PM, Ahnen D, Byers T, Bresalier R, Syummers R, Bond j, Eyssen G, Sandler R, Haile R, Baron J. Colorectal Adenomas in a Randomized Folate Trial: The Role of Baseline Dietary and Circulating Folate Levels. Cancer Epidemiology Biomarkers & Prevention 17:2625-31, 10/2008.
9. Bresalier RS. Barrett's esophagus and esophageal adenocarcinoma. Annual Review of Medicine. e-Pub 9/2008.
10. Qiu Y, Patwa TH, Xu L, Shedden K, Misek DE, Tuck M, Jin G, Ruffin MT, Turgeon DK, Synal S, Bresalier R, Marcon N, Brenner DE, Lubman DM. Plasma glycoprotein profiling for colorectal cancer biomarker identification by lectin glycoarray and lectin blot. J Proteome Res 7(4):1693-703, 4/2008. PMID: 18311904.
11. Bresalier RS. Chemoprevention of colorectal cancer: why all the confusion? Curr Opin Gastroenterol 24(1):48-50, 1/2008. PMID: 18043232.
12. Tong Z, Kunnumakkara AB, Wang h, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, and Guha S. Neutrophil Gelatinase-Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer. Cancer Research 68:6100-6108, 2008.

Invited Articles
1. Davila M, Bresalier RS. Treatment of gastrointestinal complications of oncologic therapy. Nature: Clinical Practice in Gastroenterology and Hepatology 5(12):682-96, 12/2008.
2. Bresalier RS. Chemoprevention of colorectal cancer: why all the confusion? Current Opinion in Gastroenterology 24:48, 2008.
3. Bresalier RS. Chemoprevention of colorectal neoplasia: advances and controversies (the COX-2 story). Curr Opin Gastroenterol 23:44-7, 2007. PMID: 17133084.
4. Bresalier RS. Management of Barrett's Esophagus. Cases and Questions. Seminars in Oncology 2 (/suppl 9):2-5, 2005.

Book Chapters
1. Byrd JC and Bresalier RS. Galectin-3 in the progression and metastasis of colorectal neoplasia. In: Galectins. 60. John Wiley and Sons, 221-232, 2009.

Books (edited and written)
1. Bresalier, RS. Current Opinion in Gastroenterology. In: Large Intestine. 24, No. 1. Lippincott, Williams and Wilkins, 2008.

Grant & Contract Support

Title: Mucin glycoproteins in colorectal cancer metastasis
Funding Source: National Institutes of Health/National Cancer Institute
Role: Principal Investigator
Duration: 9/1/2006 - 8/1/2012
 
Title: Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett’s Esophagus
Funding Source: This multi-center study has been funded by NCI under a Phase I/Phase II Trials of Chemoprevention Contract
Role: Robert S. Bresalier, Co-Investigator, Center Principal Investigator
Principal Investigator: Andrew Joe
Duration: 2006 - 2009
 
Title: 15-LOX-1 and Clinical Chemoprevention of Colon Tumors
Funding Source: National Cancer Institute, National Institutes of Health
Role: Robert S. Bresalier, Co-Investigator
Principal Investigator: Shureiqi
Duration: 4/1/2005 - 3/30/2008
 
Title: Early Detection Research Network. Great Lakes-New England Clinical and Epidemiology Center
Funding Source: National Cancer Institute
Role: Robert S. Bresalier, Co-Investigator, Center Principal Investigator
Principal Investigator: Dean Brenner
Duration: 3/1/2005 - 2/1/2010
 
Title: Calcium/Vitamin D, Biomarkers and Colon Polyp Prevention
Funding Source: National Cancer Institute, National Institutes of Health
Role: Robert S. Bresalier, Co-Investigator, Center Principal Investigator
Principal Investigator: Robert Bostic,
Duration: 1/1/2005 - 12/31/2009
 
Title: Colorectal Chemoprevention with Calcium and Vitamin D
Funding Source: National Cancer Institute-National Institutes of Health
Role: Robert S. Bresalier, Co-Investigator, Center Principal Investigator
Principal Investigator: Baron
Duration: 1/1/2004 - 8/31/2013

Last updated: 9/14/2009