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Ronald A. DePinho, M.D.

Present Title & Affiliation

Primary Appointment

President, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Cancer Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1998 Harvard University, Cambridge, MA, MS, (Hon.)
1981 Albert Einstein College of Medicine, Bronx, NY, MD, with distinction, Microbiology and Immunology
1977 Fordham College, New York, NY, BS, Salutatorian and Summa Cum Laude, Biological Sciences

Postgraduate Training

1984-1988 Postdoctoral Fellowship, Albert Einstein College of Medicine, Department of Biochemistry & Biophysics, Bronx, NY, Dr. Frederick Alt
1984-1985 Postdoctoral Fellowship, Albert Einstein College of Medicine, Department of Cell Biology, Bronx, NY, Dr. Matthew Scharff

Board Certifications

1984 Board Certified in Internal Medicine

Experience/Service

Academic Appointments

Professor of Medicine (Genetics), Harvard Medical School, Boston, MA, 1998-2011
Professor, Departments of Microbiology & Immunology & Medicine, Albert Einstein College of Medicine, Bronx, NY, 1997-1998
Associate Professor, Departments of Microbiology & Immunology & Medicine, Albert Einstein College of Medicine, Bronx, NY, 1993-1997
Assistant Professor, Departments of Microbiology & Immunology & Medicine, Albert Einstein College of Medicine, Bronx, NY, 1988-1993

Administrative Appointments/Responsibilities

Director, Belfer Institute for Applied Cancer Science (f/k/a/ Center for Applied Cancer Science), Dana-Farber Cancer Institute, Boston, MA, 2004-2011
Scientific Director, Mouse Specialized Services, Dana-Farber/Harvard Cancer Center, Boston, MA, 1999-2004
Scientific Director, Transgenic & Gene Targeting Facility, Dana-Farber Cancer Institute, Boston, MA, 1998-2011
Scientific Director, Transgenic & Gene Targeting Facility, Albert Einstein College of Medicine, Bronx, NY, 1988-1998

Other Appointments/Responsibilities

Organizer & Director, NCI Mouse Developmental Genetics Course, Albert Einstein College of Medicine, Bronx, NY, 1991-1998
Attending Physician, Jacobi Hospital, Albert Einstein College of Medicine, Bronx, NY, 1988-1997
Co-Founder and Director, Scientific Advisory Board, AVEO Pharmaceuticals, Inc. (f/k/a GenPath), Cambridge, MA
Co-Founder and Director, Scientific Advisory Board, Eden Therapeutics, Inc., Houston, TX
Co-Founder and Director, Scientific Advisory Board, Metamark Genetics, Inc., Cambridge, MA

Consultantships

Scientific Advisory Board, Sidney Kimmel Foundation, Philadelphia, PA

Honors and Awards

2010 Member, American Academy of Arts and Sciences
2009 Albert Szent-Györgyi Prize for Progress in Cancer Research
2007 Biomedicum Helsinki Medal and Lecture
2007 Harvey Society Lecture
2004 Albert Einstein College of Medicine Distinguished Alumnus Award
2004 American Cancer Society Research Professorship (Edith A. Pistorino, Professor)
2004 Member, Institute of Medicine of the National Academies
2003 AACR-G.H.A. Clowes Memorial Award
2003 The Ellison Medical Foundation Senior Scholar Award
2002 American Society for Clinical Investigation Award (now Korsmeyer Award)
2000 Clair W. & Richard P. Morse Research Award, Dana Farber Cancer Institute, Boston
2000 Kirsch Senior Investigator Award
1998-2008 American Cancer Society Research Professorship
1995 Irma T. Hirschl Career Scientist Award
1993 Melini Award for Excellence in Biomedical Research
1992 American Heart Association Established Investigator Award
1992 Feinberg Senior Faculty Scholar in Cancer Research
1989 Cancer Research Institute Investigator Award
1989 March of Dimes Basil O'Connor Scholar Award
1988 James S. McDonnell Foundation Scholar Award
1981 Eli H. Rubin Award in Medicine
1981 M.D. with distinction in Microbiology and Immunology, Albert Einstein College of Medicine
1977 Salutatorian and Summa Cum Laude, Fordham University
1977 Steinbugler Award for Biology, Fordham University
1976 Phi Beta Kappa, Fordham University

Professional Memberships

American Association for Cancer Research
Chair, Centennial Meeting, 2007
Education Committee, 1997
Member, 1992-present
American Association for the Advancement of Science
Member, 1986-present
American Society for Clinical Investigation
Member, 1999-present
Institute of Medicine
Chair, Section 2, Membership Committee, 2007-2010
National Cancer Institute
Board of Scientific Advisors (BSA)

Selected Publications

Peer-Reviewed Original Research Articles
1. Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 470(7333):269-73, 2/10/2011. e-Pub 2/2/2011. PMID: 21289624.
2. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470(7334):359-65, 2/17/2011. e-Pub 2/9/2011. PMID: 21307849.
3. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469(7328):102-6, 1/6/2011. e-Pub 11/28/2010. PMCID: PMC3057569.
4. Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, DePinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-4, 12/2010. PMCID: PMC3058342.
5. Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-84, 11/16/2010. PMCID: PMC3023886.
6. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 5/18/2010. PMCID: PMC2900858.
7. Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540-53, 11/6/2009. PMID: 19896444.
8. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455(7216):1129-33, 10/23/2008. PMID: 18948956.
9. Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318(5848):287-90, 10/12/2007. e-Pub 9/13/2007. PMID: 17872411.
10. Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447(7147):966-71, 6/21/2007. e-Pub 5/21/2007. PMCID: PMC2714968.
11. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128(2):309-23, 1/26/2007. PMCID: PMC1855089.
12. Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421(6923):643-8, 2/6/2003. e-Pub 1/22/2003. PMID: 12540856.
13. Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature 400(6743):468-72, 7/29/1999. PMID: 10440378.
14. Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97(4):527-38, 5/14/1999. PMID: 10338216.
15. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 392(6676):569-74, 4/9/1998. PMID: 9560153.

Grant & Contract Support

Title: Systematic functional interrogation of the GBM genome for curative combination therapy
Funding Source: Ben and Catherine Ivy Foundation
Role: Co-Principal Investigator
Duration: 1/1/2010 - 12/31/2012
 
Title: Uses of GEM models for Translational Cancer Research
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Chin/DePinho
Duration: 7/1/2009 - 6/30/2014
 
Title: Genetics and Biology of Pancreatic Ductal Adenocarcinoma
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/15/2006 - 12/31/2015
 
Title: Telomerase in Development, Senescence and Neoplasia
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/6/2005 - 12/31/2014
 
Title: Myeloma SPORE: Lung, Leukemia and Myeloma Cancers Project 2
Funding Source: NIH/NCI
Role: Investigator
Principal Investigator: Ken Anderson
Duration: 7/1/2003 - 6/30/2013
 
Title: Genetics and Biology of Malignant Glioma
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 3/10/2003 - 2/28/2013
 
Title: The Role of PTEN and the PI3K Pathway in Prostate Cancer-Mouse Genome Manipulation Core
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 4/1/2001 - 5/31/2012
 
Title: NCI Cancer Center Support Grant
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/1978 - 6/30/2013

Last updated: 6/15/2012