Meet Rosa Hwang, M.D.
Rosa F. Hwang, M.D., F.A.C.S.
Department of Breast Surgical Oncology, Division of Surgery
Featured Articles
Present Title & Affiliation
Primary Appointment
Professor, Department of Breast Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1993 | University of Maryland at Baltimore, Baltimore, MD, USA, MD, Medicine |
| 1989 | University of Maryland, College Park, MD, USA, BS, Zoology and Psychology |
Postgraduate Training
| 2001-2002 | Research Fellowship, Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2000-2003 | Fellowship, Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1995-1997 | Research Fellow, Gene Therapy Laboratories, The University of Southern California-Keck School of Medicine, Los Angeles, CA |
| 1993-2000 | Resident, General Surgery, The University of Southern California-Keck School of Medicine, Los Angeles, CA |
Board Certifications
| 2003 | American Board of Surgery |
Experience & Service
Academic Appointments
Associate Professor, Department of Breast Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2018
Assistant Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2010
Assistant Professor, Department of Surgical Oncology, Division of Surgery, University of California, San Diego, San Diego, CA, 2003 - 2004
Other Appointments/Responsibilities
Committee Member Education Committee, Association for Academic Surgery (AAS), Los Angeles, CA, 2011 - 2013
Committee Member, The Pancreas Club, Inc, Planning Committee 46th Annual Pancreas Club Meeting, San Diego, CA, Carol Stream, IL, 2011 - Present
Member, American Society of Breast Surgeons (ASBS) Publications Committee, Columbia, MD, 2009 - Present
Reviewer, Program Committee, Society for Surgery of the Alimentary Tract (SSAT) Annual Meeting, Washington, DC, 2007 - Present
Institutional Committee Activities
Associate Member, Office of Protocol Research - Institutional Review Board 2, The University of Texas MD Anderson Cancer Center, 2013 - Present
Chair, Surgical Innovation Committee, The University of Texas MD Anderson Cancer Center, 2013 - Present
Chair, Breast Tissue Oversight Committee, The University of Texas MD Anderson Cancer Center, 2012 - 2012
Alternate Member, Institutional Tissue Utilization Committee (iTUC), The University of Texas MD Anderson Cancer Center, 2011 - Present
Committee Member, Computerized Provider Order Entry (CPOE) Steering Committee, The University of Texas MD Anderson Cancer Center, 2010 - Present
Primary Member, Breast Tissue Oversight Committee, The University of Texas MD Anderson Cancer Center, 2010 - 2013
Committee Member, Breast Cancer Screening Guidelines Development Team, The University of Texas MD Anderson Cancer Center, 2009 - Present
Member, Clinical Research Committee (CRC), The University of Texas MD Anderson Cancer Center, 2008 - 2011
Member, Biospecimen Repository Advisory Committee (BRAC) - Pancreas Bank, The University of Texas MD Anderson Cancer Center, 2008 - Present
Voting Member, Clinical Effectiveness Committee, The University of Texas MD Anderson Cancer Center, 2007 - 2013
Organizing Committee Member, Breast Cancer Research Group Retreat, Triple Negative/Basal-Like Breast Cancers, The University of Texas MD Anderson Cancer Center, 2006 - Present
Director, Pancreas Satellite Tissue Bank, The University of Texas MD Anderson Cancer Center, 2005 - Present
Honors & Awards
| 2013 | Conquer Cancer Foundation of American Society of Clinical Oncology (ASCO) Merit Award given to Elizabeth FitzSullivan, M.D., Surgical Breast Fellow (supervising faculty, RF Hwang, M.D.), Conquer Cancer Foundation Board of Directors and the Breast Cancer Symposium Program Committee |
| 2012 | American Society of Clinical Oncology (ASCO) Conquer Cancer Foundation Merit Award given to Lisa Allen, M.D., Surgical Breast Fellow (supervising faculty, RF Hwang, M.D.), American Society of Clinical Oncology (ASCO) Conquer Cancer Foundation Board of Directors and the Breast Cancer Symposium Program Committee |
| 2011 | Certificate of Excellence, Laboratory Investigation Journal |
| 2011 | American Association for Cancer Research (AACR) Scholar-in-Training Award given to Sarah Gainer, M.D. Surgical Breast Fellow (supervising faculty, RF Hwang, M.D.), American Association for Cancer Research (AACR) |
| 2008 | Trainee Travel Award for Oral Abstract Presented at "The Chronic Pancreatitis to Pancreatic Cancer Continuum", American Pancreatic Association (Awardee-Armando Rivera, Ph.D.; Supervising Faculty-RF Hwang, MD |
| 2008 | America's Top Oncologists, Consumer's Research Council of America |
| 2006 | Awardee, American Association for Cancer Research Minority Scholar Award in Cancer Research, American Association of Cancer Research |
| 2006 | Career Development Award, Society for Surgery of the Alimentary Tract (SSAT), Principal, Investigator, Tumor-stromal interactions in the regulation of pancreatic cancer progression, $100,000 ($50,000/year) |
| 2006 | Teaching Award, The University of Texas MD Anderson Cancer Center for Biomedical Engineering |
| 2006 | Career Development Award, The University of Texas M. D. Anderson Cancer Center Pancreas SPORE Career Development Award (5P20 CA101936), Principal Investigator, The role of tumor-associated stroma in the regulation of pancreatic cancer progression, $50,000 ($50,000/year) |
| 2005 | Teaching Award, The University of Texas MD Anderson Cancer Center for Biomedical Engineering |
| 2002 | Awardee, Research Fellowship, Method in Clinical Cancer Research Workshop, American Association for Cancer Research/American Society for Clinical Oncology |
| 2001 | Awardee, Research Fellowship, Molecular Biology and Clinical Oncology Workshop, American Association for Cancer Research/American Society for Clinical Oncology |
| 1989 | Phi Sigma Honor Society |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG. Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells. Sci Rep 8(1):13225, 2018. e-Pub 2018. PMID: 30185888.
- Weiss A, Mittendorf EA, DeSnyder SM, Hwang RF, Bea V, Bedrosian I, Hoffman K, Adrade B, Sahin AA, Kuerer HM, Hunt KK, Caudle AS. Expanding Implementation of ACOSOG Z0011 in Surgeon Practice. Clin Breast Cancer 18(4):276-281, 2018. e-Pub 2017. PMID: 29100726.
- Kuerer HM, Rauch GM, Krishnamurthy S, Adrada BE, Caudle AS, DeSnyder SM, Black DM, Santiago L, Hobbs BP, Lucci A, Gilcrease M, Hwang RF, Candelaria RP, Chavez-MacGregor M, Smith BD, Arribas E, Moseley T, Teshome M, Miggins MV, Valero V, Hunt KK, Yang WT. A Clinical Feasibility Trial for Identification of Exceptional Responders in Whom Breast Cancer Surgery Can Be Eliminated Following Neoadjuvant Systemic Therapy. Ann Surg 267(5):946-951, 2018. PMID: 28549010.
- Chakravarthy D, Muñoz AR, Su A, Hwang RF, Keppler BR, Chan DE, Halff G, Ghosh R, Kumar AP. Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1. Cancer Lett 419:103-115, 2018. PMID: 29414301.
- Akay CL, Albarracin C, Torstenson T, Bassett R, Mittendorf EA, Yi M, Kuerer HM, Babiera GV, Bedrosian I, Hunt KK, Hwang RF. Factors impacting the accuracy of intra-operative evaluation of sentinel lymph nodes in breast cancer. Breast J 24(1):28-34, 2018. e-Pub 2017. PMID: 28608612.
- Raphael B, The Cancer Genome Atlas. Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. Cancer Cell 32(2):185-203.e13, 2017. PMID: 28810144.
- Tadros AB, Yang WT, Krishnamurthy S, Rauch GM, Smith BD, Valero V, Black DM, Lucci A, Caudle AS, DeSnyder SM, Teshome M, Barcenas CH, Miggins M, Adrada BE, Moseley T, Hwang RF, Hunt KK, Kuerer HM. Identification of Patients With Documented Pathologic Complete Response in the Breast After Neoadjuvant Chemotherapy for Omission of Axillary Surgery. JAMA Surg 152(7):665-670, 2017. PMID: 28423171.
- Ware MJ, Keshishian V, Law JJ, Ho JC, Favela CA, Rees P, Smith B, Mohammad S, Hwang RF, Rajapakshe K, Coarfa C, Huang S, Edwards DP, Corr SJ, Godin B, Curley SA. Generation of an in vitro 3D PDAC stroma rich spheroid model. Biomaterials 108:129-42, 2016. e-Pub 2016. PMID: 27627810.
- Caudle AS, Yang WT, Mittendorf EA, Black DM, Hwang RF, Hobbs B, Hunt KK, Krishnamurthy S, Kuerer HM. Selective surgical localization of axillary lymph nodes containing metastases in patients with breast cancer: a prospective feasibility trial. JAMA Surg 150(2):137-43, 2015. PMID: 25517573.
- Martínez-Bosch N, Fernández-Barrena MG, Moreno M, Ortiz-Zapater E, Munné-Collado J, Iglesias M, André S, Gabius HJ, Hwang RF, Poirier F, Navas C, Guerra C, Fernández-Zapico ME, Navarro P. Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation. Cancer Res 74(13):3512-24, 2014. e-Pub 2014. PMID: 24812270.
- Shields MA, Ebine K, Sahai V, Kumar K, Siddiqui K, Hwang RF, Grippo PJ, Munshi HG. Snail cooperates with KrasG12D to promote pancreatic fibrosis. Mol Cancer Res 11(9):1078-87, 2013. e-Pub 2013. PMID: 23761168.
- Ma Y, Hwang RF, Logsdon CD, Ullrich SE. Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer. Cancer Res 73(13):3927-37, 2013. e-Pub 2013. PMID: 23633481.
- Charo C, Holla V, Arumugam T, Hwang RF, Yang P, Dubois RN, Menter DG, Logsdon CD, Ramachandran V. Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor. Pancreas 42(3):467-74, 2013. e-Pub 2012. PMID: 23090667.
- Yi M, Kuerer HM, Mittendorf EA, Hwang RF, Caudle AS, Bedrosian I, Meric-Bernstam F, Wagner JL, Hunt KK. Impact of the American College of Surgeons Oncology Group Z0011 criteria applied to a contemporary patient population. J Am Coll Surg 216(1):105-13, 2013. e-Pub 2012. PMID: 23122536.
- Alvarado R, Yi M, Le-Petross H, Gilcrease M, Mittendorf EA, Bedrosian I, Hwang RF, Caudle AS, Babiera GV, Akins JS, Kuerer HM, Hunt KK. The role for sentinel lymph node dissection after neoadjuvant chemotherapy in patients who present with node-positive breast cancer. Ann Surg Oncol 19(10):3177-84, 2012. e-Pub 2012. PMID: 22772869.
- Hwang RF, Moore TT, Hattersley MM, Scarpitti M, Yang B, Devereaux E, Ramachandran V, Arumugam T, Ji B, Logsdon CD, Brown JL, Godin R. Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res 10(9):1147-57, 2012. e-Pub 2012. PMID: 22859707.
- Kim MP, Truty MJ, Choi W, Kang Y, Chopin-Lally X, Gallick GE, Wang H, McConkey DJ, Hwang RF, Logsdon C, Abbruzzesse J, Fleming JB. Molecular Profiling of Direct Xenograft Tumors Established from Human Pancreatic Adenocarcinoma After Neoadjuvant Therapy. Ann Surg Oncol 19 Suppl 3:395-403, 2012. e-Pub 2011. PMID: 21701930.
- Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. StellaTum: current consensus and discussion on pancreatic stellate cell research. Gut 61(2):172-8, 2012. e-Pub 2011. PMID: 22115911.
- Mittendorf EA, Hunt KK, Boughey JC, Bassett R, Degnim AC, Harrell R, Yi M, Meric-Bernstam F, Ross MI, Babiera GV, Kuerer HM, Hwang RF. Incorporation of sentinel lymph node metastasis size into a nomogram predicting non-sentinel lymph node involvement in breast cancer patients with a positive sentinel lymph node. Ann Surg 255(1):109-15, 2012. PMID: 22167004.
- Krantz SB, Shields MA, Dangi-Garimella S, Cheon EC, Barron MR, Hwang RF, Rao MS, Grippo PJ, Bentrem DJ, Munshi HG. MT1-MMP cooperates with KrasG12D to promote pancreatic fibrosis through increased TGF-{beta} signaling. Mol Cancer Res 9(10):1294-304, 2011. e-Pub 2011. PMID: 21856775.
- Caudle AS, Hunt KK, Kuerer HM, Meric-Bernstam F, Lucci A, Bedrosian I, Babiera GV, Hwang RF, Ross MI, Feig BW, Hoffman K, Litton JK, Sahin AA, Yang W, Hortobagyi GN, Buchholz TA, Mittendorf EA. Multidisciplinary Considerations in the Implementation of the Findings from the American College of Surgeons Oncology Group (ACOSOG) Z0011 Study: A Practice-Changing Trial. Ann Surg Oncol 18(9):2407-12, 2011. e-Pub 2011. PMID: 21327455.
- Arumugam T, Brandt W, Ramachandran V, Moore TT, Wang H, May FE, Westley BR, Hwang RF, Logsdon CD. Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis. Pancreas 40(6):815-22, 2011. PMID: 21747314.
- Yi M, Buchholz TA, Meric-Bernstam F, Bedrosian I, Hwang RF, Ross MI, Kuerer HM, Luo S, Gonzalez-Angulo AM, Buzdar AU, Symmans WF, Feig BW, Lucci A, Huang EH, Hunt KK. Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning. Ann Surg 253(3):572-9, 2011. PMID: 21209588.
- Valero V, Kong AL, Hunt KK, Yi M, Hwang RF, Meric-Bernstam F, Bedrosian I, Ross MI, Babiera GV, Litton JK, Mittendorf EA. Sentinel lymph node dissection is technically feasible in older breast cancer patients. Clin Breast Cancer 10(6):477-82, 2010. PMID: 21147692.
- Sharma R, Bedrosian I, Lucci A, Hwang RF, Rourke LL, Qiao W, Buchholz TA, Kronowitz SJ, Krishnamurthy S, Babiera GV, Gonzalez-Angulo AM, Meric-Bernstam F, Mittendorf EA, Hunt KK, Kuerer HM. Present-Day Locoregional Control in Patients with T1 or T2 Breast Cancer with 0 and 1 to 3 Positive Lymph Nodes After Mastectomy Without Radiotherapy. Ann Surg Oncol 17(11):2899-908, 2010. e-Pub 2010. PMID: 20443145.
- Bose D, Tamm E, Liu J, Marcal L, Balachandran A, Bhosale P, Fleming JB, Lee JE, Evans DB, Hwang RF. Multidisciplinary management strategy for incidental cystic lesions of the pancreas. J Am Coll Surg 211(2):205-215, 2010. e-Pub 2010. PMID: 20670858.
- Goicoechea SM, Bednarski B, Stack C, Cowan DW, Volmar K, Thorne L, Cukierman E, Rustgi AK, Brentnall T, Hwang RF, McCulloch CA, Yeh JJ, Bentrem DJ, Hochwald SN, Hingorani SR, Kim HJ, Otey CA. Isoform-specific upregulation of palladin in human and murine pancreas tumors. PLoS One 5(4):e10347, 2010. e-Pub 2010. PMID: 20436683.
- Krishnamurthy S, Meric-Bernstam F, Lucci A, Hwang RF, Kuerer HM, Babiera G, Ames FC, Feig BW, Ross MI, Singletary E, Hunt KK, Bedrosian I. A prospective study comparing touch imprint cytology, frozen section analysis and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer. Cancer 115(7):1555-1562, 2009. PMID: 19195040.
- Katz MH, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey JN, Abdalla EK, Lee JE, Pisters PW, Evans DB. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol 16(4):836-847, 2009. e-Pub 2009. PMID: 19194760.
- Yi M, Meric-Bernstam F, Middleton LP, Arun BK, Bedrosian I, Babiera GV, Hwang RF, Kuerer HM, Yang W, Hunt KK. Predictors of contralateral breast cancer in patients with unilateral breast cancer undergoing contralateral prophylactic mastectomy. Cancer 115(5):962-971, 2009. e-Pub 2009. PMID: 19172584.
- Ramachandran V, Arumugam T, Langley R, Hwang RF, Vivas-Mejia P, Sood AK, Lopez-Berestein G, Logsdon CD. The ADMR Receptor Mediates the Effects of Adrenomedullin on Pancreatic Cancer Cells and on Cells of the Tumor Microenvironment. PLoS One 4(10):e7502, 2009. e-Pub 2009. PMID: 19847298.
- Liang JJ, Wang H, Rashid A, Tan TH, Hwang RF, Hamilton SR, Abbruzzese JL, Evans DB, Wang H. Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin Cancer Res 14(21):7043-7049, 2008. PMID: 18981001.
- Yi M, Krishnamurthy S, Kuerer HM, Meric-Bernstam F, Bedrosian I, Ross MI, Ames FC, Lucci A, Hwang RF, Hunt KK. Role of primary tumor characteristics in predicting positive sentinel lymph nodes in ductal carcinoma in situ or microinvasive breast cancer. Am J Surg 196(1):81-87, 2008. e-Pub 2008. PMID: 18436181.
- Yi M, Meric-Bernstam F, Ross MI, Akins JS, Hwang RF, Lucci A, Kuerer HM, Babiera GV, Gilcrease MZ, Hunt KK. How many sentinel lymph nodes are enough during sentinel lymph node dissection for breast cancer?. Cancer 113(1):30-37, 2008. e-Pub 2008. PMID: 18457326.
- Katz MH, Mortenson MM, Wang H, Hwang RF, Tamm EP, Staerkel G, Lee JH, Evans DB, Fleming JB. Diagnosis and management of cystic neoplasms of the pancreas: an evidence-based approach. J Am Coll Surg 207(1):106-120, 2008. e-Pub 2008. PMID: 18589369.
- Hwang RF, Wang H, Lara A, Gomez H, Chang T, Sieffert N, Moon Y, Ram S, Zimmerman S, Lee JH, Pisters PW, Tamm EP, Fleming JB, Abbruzzese JL, Evans DB. Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer. Ann Surg Oncol 15(5):1356-1366, 2008. e-Pub 2008. PMID: 18256882.
- Katz MH, Pisters PW, Evans DB, Sun CC, Lee JE, Fleming JB, Vauthey JN, Abdalla EK, Crane CH, Wolff RA, Varadhachary GR, Hwang RF. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg 206(5):833-846, 2008. e-Pub 2008. PMID: 18471707.
- Khalifeh IM, Albarracin C, Diaz LK, Symmans FW, Edgerton ME, Hwang RF, Sneige N. Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. Am J Surg Pathol 32(4):544-552, 2008. e-Pub 2008. PMID: 18300793.
- Katz MH, Hwang RF, Fleming JB, Evans DB. Tumor-node-metastasis staging of pancreatic adenocarcinoma. CA Cancer J Clin 58(2):111-125, 2008. e-Pub 2008. PMID: 18272835.
- Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB, Logsdon CD. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. (Highlighted Article). Cancer Res 68(3):918-926, 2008. PMID: 18245495.
- Hwang RF, Gonzalez-Angulo AM, Yi M, Buchholz TA, Meric-Bernstam F, Kuerer HM, Babiera GV, Tereffe W, Liu DD, Hunt KK. Low local-regional failure rates in selected breast cancer patients with tumor-positive sentinel nodes who do not undergo completion axillary dissection. Cancer 110(4):723-730, 2007. PMID: 17587208.
- Baruch AC, Wang H, Staerkel GA, Evans DB, Hwang RF, Krishnamurthy S. Immunocytochemical study of the expression of mesothelin in fine-needle aspiration biopsy specimens of pancreatic adenocarcinoma. Diagn Cytopathol 35(3):143-147, 2007. PMID: 17304533.
- Ramachandran V, Arumugam T, Hwang RF, Greenson JK, Simeone DM, Logsdon CD. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor (ADMR). Cancer Res 67(6):2666-2675, 2007. PMID: 17363587.
- Raut CP, Tseng JF, Sun CC, Cleary KR, Wang H, Wolff RA, Abbruzzese JF, Varadhachary G, Tamm EP, Crane CH, Gomez HF, Hwang RF, Vauthey JN, Abdalla EK, Lee JE, Pisters PWT, Evans DB. Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Ann Surg 246(1):52-60, 2007. PMID: 17592291.
- Boughey JC, Ross MI, Babiera GV, Bedrosian I, Feig BW, Hwang RF, Kuerer HM, Hunt KK. Sentinel lymph node surgery in locally recurrent breast cancer. Clin Breast Cancer 7(3):248-253, 2006. PMID: 16942642.
- Lambert LA, Ayers GD, Hwang RF, Hunt KK, Ross MI, Kuerer HM, Singletary SE, Babiera GV, Ames FC, Feig B, Lucci A, Krishnamurthy S, Meric-Bernstam F. Validation of a breast cancer nomogram for predicting nonsentinel lymph node metastases after a positive sentinel node biopsy. Ann Surg Oncol 13(3):310-320, 2006. e-Pub 2006. PMID: 16463073.
- Rosenkranz KM, Bedrosian I, Feng L, Hunt KK, Hartman K, Lucci A, Meric-Bernstam F, Kuerer HM, Singletary ES, Hwang RF, Feig B, Ross M, Ames F, Babiera GV. Breast cancer in the very elderly: treatment patterns and complications in a tertiary cancer center. Am J Surg 192(4):541-544, 2006. PMID: 16978971.
- Garmy-Susini B, Jin H, Zhu Y, Sung RJ, Hwang RF, Varner J. Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest 115(6):1542-1551, 2005. e-Pub 2005. PMID: 15902308.
- Hwang RF, Yokoi K, Bucana CD, Tsan R, Killion JJ, Evans DB, Fidler IJ. Inhibition of platelet-derived growth factor reception phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. (Cover Article). Clin Cancer Res 9(17):6534-6544, 2003. PMID: 14695158.
- Solorzano CC, Hwang RF , Baker CH, Bucana CD, Pisters PW, Evans DB, Killion JJ, Fidler IJ. Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. Clin Cancer Res 9(5):1858-1867, 2003. PMID: 12738744.
- Hwang RF, Krishnamurthy S, Hunt KK, Mirza N, Ames FC, Feig B, Kuerer HM, Singletary SE, Babiera G, Meric F, Akins JS, Neely J, Ross MI. Clinicopathologic factors predicting involvement of nonsentinel axillary nodes in women with breast cancer. Ann Surg Oncol 10(3):248-254, 2003. PMID: 12679309.
- Hwang RF, Hunt KK. Experimental approaches to treatment of soft tissue sarcoma. Surg Oncol Clin N Am 12(2):499-521, 2003. PMID: 12916466.
- Hwang RF, Gordon EM, Anderson WF, Parekh D. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. Surgery 124(2):143-150; discussion 150-151, 1998. PMID: 9706132.
- Yang L, Hwang RF, Chiang Y, Gordon EM, Anderson WF, Parekh D. Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex thymidine kinase gene. Clin Cancer Res 4(3):731-741, 1998. PMID: 9533543.
- Yang L, Hwang RF , Pandit L, Gordon EM, Anderson WF, Parekh D. Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir. Ann Surg 224(3):405-414; discussion 414-417, 1996. PMID: 8813269.
Invited Articles
- Hwang RF. Commentary on: A simple nomogram to evaluate the risk of nonsentinel node metastases in breast cancer patients with minimal sentinel node involvement. Breast Diseases: A Year Book Quarterly 23(3):260-261, 2012.
- Sharma R, Wagner JL, Hwang RF. Ablative therapies of the breast. Surg Oncol Clin N Am 20(2):317-339, 2011. PMID: 21377586.
- Hwang RF. Commentary on: Axillary recurrence is low in patients with breast cancer who do not undergo completion axillary lymph node dissection for micrometastases in sentinel lymph nodes. Am Surg 76:1088-1091, 2010. Breast Diseases: A Year Book Quarterly 22(4):396-397, 2011.
- Hwang RF, Giuliano A, Sahin A, Feldman S, Van Zee K. Regional management of breast cancer: Highlights from the 11th Annual Meeting of the American Society of Breast Surgeons, Las Vegas, NV. Ann Surg Oncol 17(Suppl 3):S226-S229, 2010. e-Pub 2010. PMID: 20853037.
- Hwang RF. Commentary on: Predictors to assess non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis. Breast Diseases: A Year Book Quarterly 20(4):417, 2010.
- Hwang RF. Commentary on: Validation of a nomogram to predict the risk of nonsentinel lymph node metastases in breast cancer patients with a positive sentinel node biopsy: validation of the MSKCC breast nomogram. Breast Diseases: A Year Book Quarterly 21(1):58, 2010.
- Hwang RF. Commentary on: Nomogram for the predicting of having four or more involved nodes for sentinel lymph node-positive breast cancer. Breast Diseases: A Year Book Quarterly 20(1):68, 2009.
- Hwang RF. Commentary on: Evaluation of a breast cancer nomogram for prediction of nonsentinel lymph node positivity. Eur J Surg Oncol 31:958-964, 2005. Breast Diseases: A Year Book Quarterly 17:380-381, 2007.
- Hwang RF. Commentary on: The significance of one positive axillary node. Eur J Surg Oncol 32:139-142, 2006. Breast Diseases: A Year Book Quarterly 17:383-384, 2007.
- Hwang RF. Commentary on: The incidence and significance of micrometastases in lymph nodes of patients with ductal carcinoma in situ and T1a carcinoma of the breast. Eur J Surg Oncol 32:502-506, 2006. Breast Diseases: A Year Book Quarterly 18:80, 2007.
- Hwang RF. Commentary on: Differences in sentinel lymph node pathology protocols lead to differences in surgical strategy in breast cancer patients. Ann Surg Oncol 2006; 13: 1466-1473. Breast Diseases: A Year Book Quarterly 18:382, 2007.
- Hwang RF. Commentary on: The impact of nonvisualization of sentinel nodes of lymphoscintigraphy in breast cancer. Ann Surg Oncol 7:1-6, 2005. Breast Diseases: A Year Book Quarterly 17:79, 2006.
- Hwang RF. Commentary on: Ratio on positive to total number of sentinel nodes predicts nonsentinel node status in breast cancer patients. Breast J 11:248-253, 2005. Breast Diseases: A Year Book Quarterly 17:74-75, 2006.
- Hwang RF. Commentary on: The effect of sentinel node tumor burden on nonsentinel node status and recurrence rates in breast cancer. Ann Surg Oncol 12:705-711, 2005. Breast Diseases: A Year Book Quarterly 17:171, 2006.
- Hwang RF. Commentary on: Primary tumor characteristics predict sentinel lymph node macrometastasis in breast cancer. Breast J 11:338-343, 2005. Breast Diseases: A Year Book Quarterly 17:174, 2006.
- Hwang RF, Evans DB. CA19-9 and CA 125 markers in the differential diagnosis of pancreatic mass lesions. Arch Surg 141:974, 2006.
- Hwang RF, Varner J. The role of integrins in tumor angiogenesis. Hematol Oncol Clin North Am 18(5):991-1006, 2004. PMID: 15474331.
- Hwang RF. Commentary on: Extracapsular extension of the sentinel lymph node metastasis: a predictor of nonsentinel node tumor burden. Ann Surg 2003; 237: 607-613. Breast Diseases: A Year Book Quarterly 15:66-67, 2004.
- Hwang RF, Hunt K. Experimental approaches to soft tissue sarcoma. Surgical Oncology Clinics of North America 12(2):499-521, 2003. PMID: 12916466.
Manuals, Teaching Aids, Other Teaching Publications
- Hwang RF, Oates S. Skin-Sparing Mastectomy with Immediate Free-TRAM Reconstruction; Video Clip for "Kuerer's Breast Surgical Oncology". McGraw-Hill Professional: New York, NY, 2010.
Abstracts
- Shen MC, Bloom E, Shaitelman SF, Wei C, Haynes AB, Mittendorf EA, Kuerer HM, Bedrosian I, Hwang RF, Hunt KK, Tereffe W, Strom E, Babiera GV. Comparison of infectious complications between breast conserving therapy with cathetered-based accelerated partial irradiation and whole breast irradiation. Poster Presentation, 36th Annual San Antonio Breast Cancer Symposium (SABCS), San Antonio, TX, 2013.
- FitzSullivan E, Kuerer HM, Bassett RL, Mittendorf EA, Yi M, Hunt K, Babiera G, Caudle AS, Black DM, Bedrosian I, Meric-Bernstam F, Hwang RF. Outcomes of sentinel lymph node-positive breast cancer patients treated with mastectomy with axillary therapy. Poster Presentation, American Society of Clinical Oncology (ASCO) Breast Cancer Symposium, San Francisco, CA. J Clin Oncol 31(26 Suppl (Sep. 10 Suppl)):53, 2013.
- FitzSullivan E, Lari SA, Smith B, Caudel AS, Krishnamurthy S, Lucci A, Mittendorf EA, Babiera G, Black S, Wagner JL, Bedrosian I, Woodward W, Gainer SM, Hwang RF, Meric-Bernstam F, Hunt K, Kuerer HM. Incidence and consequence of close margins for ductal carcinoma in situ treated with mastectomy. Oral Presentation, 66th Annual Society of Surgical Oncology (SSO) Cancer Symposium, National Harbor, MD, Ann Surg Oncol 20(1 Suppl):S9, 2013.
- Hwang RF, Moore T, Mertens Hattersley M, Scarpitti M, Yang B, Devereaux E, Ramachandran V, Arumugam T, Ji B, Logsdon CD, Brown JL, Godin R. Hedgehog signaling in pancreatic cancer is dependent on stellate cells in a paracrine fashion, Oral Presentation, American Pancreatic Association (APA)/International Association of Pancreatology (IAP) Joint Annual Meeting, Miami, FL. Pancreas 41(8):1368, 2012.
- Charo C, Holla V, Arumugam T, Hwang RF, Yang P, Dubois RN, Menter DG, Logsdon CD, Ramachandran V. PGE2 regulates pancreatic stellate cell activity via the EP4 receptor, American Pancreatic Association (APA)/International Association of Pancreatology (IAP) Joint Annual Meeting, Miami, FL. Pancreas 41(8):1352, 2012.
- Arumugam T, Fujii T, Haojie H, Hwang RF, Ramachandran V, Logsdon CD. Interleukin-8 (IL-8) expression is a surrogate marker for effects of gemcitabine on pancreatic ductal adenocarcinoma (PDAC) cells, American Pancreatic Association (APA)/International Association of Pancreatology Annual Meeting, Miami, FL. Pancreas 41(8):1347, 2012.
- Allen LR, Gadgil PV, Bassett Jr. R, Hunt K, Mittendorf EA, Yi M, Babiera G, Kuerer HM, Ross MI, Bedrosian I, Meric-Bernstam F, Hwang RF. Nomogram to predict sentinel lymph node involvement in patients with clinically node-negative breast cancer receiving neoadjuvant chemotherapy. Poster Discussion Session, American Society of Clinical Oncology (ASCO) Breast Cancer Symposium, San Francisco, CA. J Clin Oncol 30(27 Suppl):150, 2012.
- Yi M, Mittendorf EA, Hwang RF, Babiera GV, Kuerer HM, Crow J, Lange R, Shah R, Hunt K. Are mastectomy rates really increasing? Experiences from a single institution and a population-based database. Poster Presentation, American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL, 2012.
- Akay C, Whitsell T, Albarracin C, Hunt KK, Bassett R, Mittendorf EA, Yi M, Sahin A, Krishnamurthy, Kuerer H, Meric-Bernstam F, Babiera GV, Bedrosian I, Hwang RF. Intraoperative sentinel lymph node evaluation is accurate after neoadjuvant therapy for breast cancer. Poster Presentation, 65th Annual Cancer Symposium Society of Surgical Oncology (SSO), Orlando, FL. Ann Surg Oncol 19(Suppl 1):S86, 2012.
- Hwang RF. Blocking tumor-stromal interactions in pancreatic cancer by targeting stromal cell-derived Dickkopf-3 (DKK3). Poster Presentation, 7th Annual Academic Surgical Congress, Las Vegas, NV, 2012.
- Veerapong J, Boughey J, Mittendorf E, Harrell R, Bassett R, Ross M, Yi M, Meric-Bernstam F, Babiera G, Kuerer H, Lucci A, Bedrosian I, Brodt J, Jakub J, Hunt K, Hwang RF. A validated risk assessment of sentinel lymph node involvement in breast cancer patients. Poster Presentation, 64th Annual Society of Surgical Oncology Cancer Symposium (SSO), San Antonio, TX. Ann Surg Oncol 18(Suppl 1):S59, 2011.
- Husted H, Moore T, Deng D, Ramachandran V, Arumugam T, Logsdon CD, Hwang RF. Stellate cell-derived Dickkopf-3 (DKK3) induces PDAC tumor progression and chemoreistance. Oral Presentation, 41st. Annual Meeting of the American Pancreatic Association, Chicago, IL. Pancreas 39(8):1324, 2010.
- Hwang RF, Rivera A, Husted H, Moore T, Ramachandran V, Arumugam T, Ji B, Logsdon CD. Targeting periostin in the tumor-associated stroma of pancreatic cancer. Oral Presentation, 5th Annual Academic Surgical Congress (ASC), San Antonio, TX, 2010.
- Husted H, Moore T, Ji B, Ramachandran V, Arumugam T, Logsdon CD, Hwang RF. Pancreatic stellate cells secrete the WNT inhibitor DKK3. Oral Presentation, 40th Anniversary Meeting of the American Pancreatic Association (APA) and Japan Pancreas Society, Honolulu, HI, 2009.
- Hwang RF, Evans DB, Coombes K, Logsdon CD. Gene expression profiling of pancreatic adenocarcinoma after neoadjuvant chemoradiation identifies potential markers of outcome. Poster Presentation, The American Association for Cancer Research (AACR), Denver, CO, 2009.
- Kong AL, Hunt KK, Warneke CL, Hwang RF, Meric-Bernstam F, Bedrosian I, Yi M, Ross MI, Babiera GV, Mittendorf EA. Sentinel node dissection (SLND) is technically feasible and accurate in older breast cancer patients. Poster Presentation, Ann Surg Oncol 16(12), 2009.
- Hwang RF, Moore T, Rivera A, Evans DB, Logsdon CB. Expression profile of pancreatic cancer-associated fibroblasts is distinct from carcinoma cells. Oral Presentation, 62nd. Annual Society of Surgical Oncology Cancer Symposium (SSO), Phoenix, AZ, 2009.
- Hwang RF, Moore T, Ramachandran V, Arumugam R, Rivera A, Logsdon CD. Pancreatic cancer-associated fibroblasts promote angiogenesis in vitro and in vivo. Oral Presentation, Gastrointestinal Cancers Symposium, San Francisco, CA, 2009.
- Rivera A, Moore T, Ramachandran V, Arumugam T, Logsdon CD, Hwang RF. Tumor-associated pancreatic stellate cells stimulate angiogenesis in vitro and in an orthotopic model of pancreatic cancer. Oral Presentation, American Pancreatic Association (APA), Chicago, IL, 2008.
- Bose D, Tamm E, Liu J, Kesmodel S, Lee JH, Gomez H, Fleming J, Evans DB, Hwang RF. Incidental cystic lesions of the pancrease: multidisciplinary management of 350 patients. Oral Presentation, 94th Annual Clinical Congress American College of Surgeons (ACS), San Francisco, CA, 2008.
- Kong AL, Hunt KK, Yi M, Weatherspoon K, Bedrosian I, Tereffe W, Hwang RF, Ross MI, Buchholz TA, Meric-Bernstam F. The impact of IMC nodal drainage on primary breast cancer outcome. Poster Presentation, American Society of Clinical Oncology (ASCO), Chicago, IL, 2008.
- Yi M, Meric-Bernstam F, Middleton LP, Arun BK, Bedrosian I, Babiera G, Hwang RF, Feig BW, Kuerer HM, Lucci A, Ross MI, Hunt KK. Predictors of contralateral breast cancer in patients with unilateral breast cancer. Poster Presentation, American Society of Breast Surgeons (ASBS), New York City, NY, 2008.
- Hwang RF. An integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer, 2nd Annual Academic Surgical Congress, Oral Presentation, Phoenix, AZ, 2007.
- Hwang RF, Moore T, Amos KD, Arumugam T, Ramachandran V, Logsdon C. Effect of pancreatic tumor-associated stellate cells on pancreatic tumor growth, metastasis and angiogenesis. Poster Presentation, 98th Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA, 2007.
- Arumugam T, Hwang RF, Moore T, Wang H, Brandt W, Westley B, Logsdon C. TFF1 is over expressed early in pancreatic cancer in response to cancer-stromal interactions and stimulates cancer cell invasiveness. Poster Presentation, 98th Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA, 2007.
- Yi M, Hunt KK, Meric-Bernstam F, Bedrosian I, Hwang RF, Kuerer HM, Lucci A, Ross MI, Akins J, Babiera GV. Sentinel lymph node biopsy in patients with multicentric invasive breast cancer. Poster Presentation, American Society of Clinical Oncology (ASCO) Breast Meeting, San Francisco, CA, 2007.
- Katz MH, Wolff RA, Pisters PW, Sun CC, Evans DB, Varadhachary GR, Fleming JB, Hwang RF. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. Oral Presentation, Southern Surgical Association (SSA) Meeting, Hot Springs, VA, 2007.
- Arumugam T, Hwang RF, Moore TT, Wang H, Brandt W, Westley BR, Logsdon C. TFF1 is overexpressed early in pancreatic cancer and stimulates cancer cell invasion and stromal cell growth and migration. Oral Presentation, International Society of Gastrointestinal Oncology, Philadelphia, PA, 2007.
- Rosenkranz KM, Hartman K, Ghonimi E, Kuerer HM, Singletary SE, Hunt KK, Meric-Bernstam F, Lucci A, Hwang RF, Feig B, Ross MI, Ames F, Babiera GV. Breast cancer in the very elderly: treatment patterns in a comprehensive cancer center, American Society of Breast Surgeons, Poster Presentation, Baltimore, MD, 2006.
- Killary AM, Frazier M, Lott S, Carter J, Stivers D, Chen J, Hwang RF, Abbruzzese J, Sens S. A functional genomic approach to biomarker discovery in pancreatic cancer, Presented as a Poster, NCI, Early Detection Research Network Steering Committee Meeting, Philadelphia, PA, 2006.
- Boughey JC, Khakpour N, Meric-Bernstam F, Ross MI, Hwang RF, Babiera GV. The routine use of sentinel lymph node surgery in prophylactic mastectomy is not warranted. Ann Surg Oncol 13:P64, 2006.
- Amos KD, Moore T, Arumugam T, Logsdon CD, Hwang RF. Pancreatic stellate cells promote malignant potential in pancreatic cancer, In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research; 2006 Apr 1-5; Washington, DC: AACR: Abstract 1679, 2006.
- Yi M, Meric-Bernstam F, Akins JS, Hwang RF, Lucci A, Babiera GV, Hunt KK. How many sentinel lymph nodes are enough during sentinel lymph node dissection for breast cancer?, 29th Annual San Antonio Breast Cancer Symposium, Poster Presentation, (Abstract # 2013). Breast Cancer Res Treat 100:S84, 2006.
- Tereffe W, Buchholz TA, Oh JL, Perkins GH, Strom EA, Woodward WA, Yu TK, Hunt KK, Hwang RF. Radiotherapy targeting of regional nodes in sentinel lymph node-positive breast cancer patients who do not undergo axillary dissection, 29th Annual San Antonio Breast Cancer Symposium, Oral Presentation, (Abstract # 4086). Breast Cancer Res Treat 100:S200, 2006.
- Hwang RF, Bucana C, Killion J, Evans D, Fidler IJ. Targeted therapy of human pancreatic cancer with STI571 (Gleevec) in an orthotopic nude mouse model. Ann Surg Onc 1:S23, 2003.
- Hwang RF, Bucana C, Killion J, Evans DB, Fidler IJ. Targeted therapy of human pancreatic cancer with RPR127963E, a novel inhibitor of platelet-derived growth factor receptor, in an orthotopic nude mouse model. J Am Coll Surgeons 195:S7, 2002.
Book Chapters
- Fleming JB, Katz MHG, Hwang RF, Varadhachary GR. Pancreatic Cancer. In: 60 Years of Survival Outcomes at the University of Texas, M. D. Anderson Cancer Center. Springer: New York, 119-132, 2013.
- Hwang RF. Stromal Barriers to Delivery. In: Mass Transport of Nanocarriers. Pan Stanford Publishing Pte. Ltd: Singapore, 83-95, 2013.
- Akay CL, Kuerer HM, Hwang RF. Sentinel Lymph Node Biopsy in Breast Cancer: The MD Anderson Cancer Center Approach. In: Advanced Therapy of Breast Disease, 3rd. Edition. 3rd. Edition. People's Medical Publishing House: Connecticut, USA, 545-555, 2012.
- Bowels TL, Amos KD, Hwang RF, Fleming JB. Small Bowel Malignancies and Carcinoid Tumors. In: The M.D. Anderson Surgical Oncology Handbook, 5th Ed. 5th Edition. Wolters Kluwer, Lippincott Williams & Wilkins: New York, 323-346, 2012.
- Kong A, Hwang RF. Sentinel Lymph Node Biopsy: An Overview. In: Breast Medical Techniques and Interdisciplinary Management. Springer: New York, 471-480, 2011.
- Logsdon C, Ji B, Hwang RF. Novel Molecular Relationships Between Chronic Pancreatitis and Pancreatic Cancer. In: Handbook of Pancreatic Cancer. Springer: New York, 285-315, 2009.
- Hwang RF, Ross MI. Treatment Options and Surgical Techniques for Early-Stage Breast Cancer. In: Advanced Therapy in Surgical Oncology. 1. B.C. Decker: Hamilton, Ontario, 489-501, 2007.
- Amos KD, Hwang RF. Small-Bowel Malignancies and Carcinoid Tumors. In: The M. D. Anderson Surgical Oncology Handbook. Lippincott Williams and Wilkins: Philadelphia, PA, 241-260, 2006.
- Hwang RF, Grau AM, Spitz FR, Bouvet M, Fuhrman GM, Berger DH. Pancreatic Adenocarcinoma. In: The M. D. Anderson Surgical Oncology Handbook. Lippincott Williams and Wilkins: Philadelphia, PA, 367-390, 2006.
- Hwang RF, Baril N, McGarvey M, Chiang M, Formenti S, Skinner K. Principles of Molecular Biology for Cancer Surgeons. In: Surgical Oncology: Multidisciplinary Approach to Difficult Problems. Oxford University Press, 1-43, 2002.
- Hwang RF, Roseman B. Metastatic Cancer of Unknown Primary Site. In: The M.D. Anderson Surgical Oncology Handbook. Lippincott Williams and Wilkins, 409-424, 2002.
- Hwang RF, Robinson E, Cusack J, Tyler D. Small Bowel Malignancies and Carcinoid Tumors. In: The M.D. Anderson Surgical Oncology Handbook. Lippincott Williams and Wilkins, 193-214, 2002.
Grant & Contract Support
| Title: | Effort, Stromal periostin in pancreatitis and pancreas cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Effort, Conditional ablation of stellate cells to determine their role in pancreatitis and pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Effort, Targeting stromal-derived dikkopf-3 (DKK3) for the prevention and treatment of pancreatic adenocarcinoma |
| Funding Source: | The University of Texas MD Anderson Cancer Center - Knowledge Gaps |
| Role: | Principal Investigator |
| Title: | Effort, Banking of Normal and Malignant Specimens (Tissue and Blood) from Patients with Pancreatic Adenocarcinoma for The Cancer Genome Atlas (TCGA) Project |
| Funding Source: | Leidos Biomedical Research |
| Role: | Principal Investigator |
| Title: | Pilot Study Evaluating the Feasibility of Robotic-Assisted Nipple Sparing Mastectomy |
| Funding Source: | Institutional Research Grant |
| Role: | Principal Investigator |
| Title: | Therapeutic Targeting of Dikkopf 3 (DKK3) for Triple Negative Breast Cancer |
| Funding Source: | The University of Texas MD Anderson Cancer Center Adverse Incident Bridge Funds |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified August 22, 2024