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Roza Nurieva, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Immunology, Tenure-Track, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin Street
Unit Number: 906
Houston, TX 77054
Room Number: SCRB 2.2019

Education & Training

Degree-Granting Education

1999 Pushchino State University, Moscow, Russian Federation, PHD, Immunology & Biochemistry
1996 Pushchino State University, Pushchino, Russia, Russian Federation, MS, Biology
1994 Kazan State University, Kazan, Russia, Russian Federation, BS, Biochemistry

Experience/Service

Academic Appointments

Assistant Professor, Non-Tenure Track, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 8/2008-8/2011
Instructor, Department of Immunology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2005-7/2008
Senior Fellow, Department of Immunology, University of Washington, Seattle, WA, 1/2001-12/2004
Research Scientist, Branch of S & O, Group of Regulatory Proteins, Institute of Bioorganic Chemistry, Pushchino, Russia, Russian Federation, 12/1999-5/2000

Honors and Awards

2015 The Journal of Biological Chemistry/Herbert Tabor Young Investigator Award, International Cytokine and Interferon Society

Selected Publications

Peer-Reviewed Original Research Articles

1. Wali S, Sahoo A, Puri S, Alekseev A, Nurieva R. Insights into the development and regulation of T follicular helper cells. Cytokine. e-Pub 6/2016. PMID: 27339151.
2. Sahoo A, Wali S, Nurieva R. T helper 2 and T follicular helper cells: Regulation and function of interleukin-4. Cytokine Growth Factor Rev, 3/2016. PMID: 27072069.
3. Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem 58(22):8970-84, 11/2015. e-Pub 11/2015. PMID: 26506089.
4. Cao AT, Yao S, Gong B, Nurieva RI, Elson CO, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunol 8(5):1072-82, 9/2015. e-Pub 1/2015. PMCID: PMC4501922.
5. Sahoo A, Alekseev A, Tanaka K, Obertas L, Lerman B, Haymaker C, Clise-Dwyer K, McMurray JS, Nurieva R. Batf is important for IL-4 expression in T follicular helper cells. Nat Commun 6:7997, 2015. e-Pub 8/2015. PMCID: PMC4557271.
6. Sahoo A, Lerman B, Alekseev A, Nurieva R. E3 ligases in T helper-2 mediated pathogenesis. Immunome Research 11(086), 2015.
7. Qin H, Lerman B, Sakamaki I, Wei G, Cha SC, Rao SS, Qian J, Hailemichael Y, Nurieva R, Dwyer KC, Roth J, Yi Q, Overwijk WW, Kwak LW. Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice. Nat Med 20(6):676-81, 6/2014. PMCID: PMC4048321.
8. Tanaka S, Tanaka K, Magnusson F, Chung Y, Martinez GJ, Wang YH, Nurieva RI, Kurosaki T, Dong C. CCAAT/Enhancer-Binding Protein α Negatively Regulates IFN-γ Expression in T Cells. J Immunol 193(12):6152-60, 2014. PMID: 25398328.
9. Sahoo A, Alekseev A, Obertas L, Nurieva R. Grail controls Th2 cell development by targeting STAT6 for degradation. Nat Commun 5:4732, 2014. PMID: 25145352.
10. Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature 507(7493):513-8, 2014. PMCID: PMC4012617.
11. Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade. Sci Signal 6(306):ra110, 2013. PMID: 24345681.
12. Liu X, Nurieva RI, Dong C. Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev 252(1):139-45, 2013. PMCID: PMC3579502.
13. Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 209(10):1841-52, 2012. PMCID: PMC3457730.
14. Ma Q, Li D, Nurieva R, Patenia R, Bassett R, Cao W, Alekseev AM, He H, Molldrem JJ, Kroll MH, Champlin RE, Sale GE, Afshar-Kharghan V. Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant 18(8):1174-81, 2012. PMCID: PMC3437318.
15. Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D. STAT5 negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem 287(14):11234-9, 2012. PMCID: PMC3322890.
16. Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A 109(22):8664-9, 2012. PMCID: PMC3365194.
17. Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten AM, Dong C. Transcription of IL17 and IL17f is controlled by Conserved Noncoding Sequence 2. Immunity 36(1):23-31, 2012. PMCID: PMC3270375.
18. Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, Rawal S, Wang YH, Lim H, Reynolds JM, Zhou XH, Fan HM, Liu ZM, Neelapu SS, Dong C. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17(8):983-8, 2011. PMCID: PMC3151340.
19. Nurieva RI, Liu X, Dong C. Molecular mechanisms of T-cell tolerance. Immunol Rev 241(1):133-44, 2011. PMID: 21488895.
20. Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of ROR{gamma}t Protein. J Biol Chem 286(26):22707-10, 2011. PMCID: PMC3123037.
21. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor -CD3 degradation. Immunity 32(5):670-680, 2010. PMCID: PMC2915546.
22. Reynolds JM, Pappu BP, Peng J, Martinez GJ, Zhang Y, Chung Y, Ma L, Yang XO, Nurieva RI, Tian Q, Dong C. Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity 32(5):692-702, 2010. PMCID: PMC2878917.
23. Nurieva RI, Chung Y. Understanding the development and function of T follicular helper cells. Cell Mol Immunol 7(3):190-7, 2010. PMID: 20383172.
24. Nurieva RI, Dong C. (IL-)12 and 21: a new kind of help in the follicles. Immunol Cell Biol 87(8):577-8, Nov-Dec, 2009. PMID: 19907426.
25. Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87, 2009. PMCID: PMC2705871.
26. Liu X, Alexiou M, Martin-Orozco N, Chung Y, Nurieva RI, Ma L, Tian Q, Kollias G, Lu S, Graf D, Dong C. Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol 182(8):4516-20, 2009. PMCID: PMC2767106.
27. Nurieva R, Yang XO, Chung Y, Dong C. Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J Immunol 182(5):2565-8, 2009. PMCID: PMC2755098.
28. Wang Y, Li D, Nurieva R, Yang J, Sen M, Carreño R, Lu S, McIntyre BW, Molldrem JJ, Legge GB, Ma Q. LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells. J Biol Chem 284(19):12645-53, 2009. PMCID: PMC2675993.
29. Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 10(12):1260-6, 2009. PMCID: PMC2784129.
30. Nurieva RI, Liu X, Dong C. Yin-Yang of costimulation: crucial controls of immune tolerance and function. Immunol Rev 229(1):88-100, 2009. PMCID: PMC2875245.
31. Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C. A critical role of costimulation during intrathymic development of invariant NKT cells. J Immunol 180(4):2276-83, 2008. PMID: 18250436.
32. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401, 2008. PMCID: PMC2752441.
33. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49, 2008. PMCID: PMC2556461.
34. Nurieva RI, Dong C. Keeping autoimmunity in check: How to control a Th17 cell controller. Immunity 29(6):841-3, 2008. PMID: 19100696.
35. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56, 2008. PMCID: PMC2630532.
36. Chang SH, Yang X, Park H, Nurieva RI, Wang YH, Zhu Z, Dong C.. Regulation of inflammatory responses by IL-17F. J Exp Med 205(5):1063-75, 2008. PMCID: PMC2373839.
37. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29-39, 2008. PMCID: PMC2587175.
38. Nurieva RI, Chuvpilo S, Wieder E, Elkon K, Locksley R, Serfling E, Dong C. A costimulation initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol 179(2):1096-1103, 2007. PMID: 17617602.
39. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448(7152):480-3, 2007. PMID: 17581589.
40. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282(13):9358-63, 2007. PMID: 17277312.
41. Xue-Zhong Y, Yaming L, Nurieva R, Fei G, Claudio A, Dong C.. Opposing effects of ICOS on Graft-versus-Host Disease Mediated by CD4 and CD8 T cells. J Immunol 176(12):7394-7401, 2006. PMID: 16751384.
42. Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J 25(11):2623-33, 2006. PMCID: PMC1478197.
43. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C.. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1069-70, 2005. PMCID: PMC1618871.
44. Nurieva RI, Mai XM, Forbush K, Bevan MJ, Dong C. B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A 100(24):14163-8, 2003. PMCID: PMC283563.
45. Dong C, Nurieva RI, Prasad DV. Immune regulation by novel costimulatory molecules. Immunol Res 28(1):39-48, 2003. PMID: 12947223.
46. Dong C, Nurieva RI. Regulation of immune and autoimmune responses by ICOS. J Autoimmun 21(3):255-60, 2003. PMID: 14599850.
47. Nurieva RI, Duong J, Kishikawa H, Dianzani U, Rojo JM, Ho I, Flavell RA, Dong C. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity 18(6):801-11, 2003. PMID: 12818161.
48. Lepikhova TN, Navolotskaya EV, Zargarova TA, Nurieva RI, Lipkin VM, Zav'yalov VP. Influence of synthetic peptide corresponding to the ACTH-like sequence of human immunoglobulin G1 on proliferation of lymphoblastoid cells. Peptides 21(3):353-7, 2000. PMID: 10793216.

Invited Articles

1. Nurieva R, Wang J, Sahoo A. T-cell tolerance in cancer. Immunotherapy 5(5):513-31, 5/2013. PMID: 23638746.

Book Chapters

1. Martinez GJ, Nurieva RI, Yang XO, Dong C. Regulation and function of proinflammatory TH17 cells. In: Annals of the New York Academy of Sciences. 1143. Ed(s) NR Rose. Wiley: New York, 188-211, 2008. ISBN: 19076351.
2. Dong C, Nurieva RI, Martin-Orozco N. Immune Regulation and Immunotherapy of Autoimmune Disease. In: Costimulation regulation of immune tolerance and autoimmunity. Ed(s) J Zhang. Springer US, Life Sciences, 121-138, 2007. ISBN: 978-0-387-36002-7.
3. Dong C, Chang S, Yang X, Nurieva R. Inflammatory T Cells: Regulation, function and pathological roles in disease. In: Effector CD4 T Cell Subsets in Health and Disease. Ed(s) S Na and C Iyer. Research Signpost, 65-84, 2007. ISBN: 978-81-7895-310-6.

Last updated: 9/6/2016