Roza I. Nurieva, Ph.D.

Peer-Reviewed Articles

1. Kim ST, Sheshadri A, Shannon V, Kontoyiannis DP, Kantarjian H, Garcia-Manero G, Ravandi F, Im JS, Boddu P, Bashoura L, Balachandran DD, Evans SE, Faiz S, Ruiz Vazquez W, Divenko M, Mathur R, Tippen SP, Gumbs C, Neelapu SS, Naing A, Wang L, Diab A, Futreal A, Nurieva R, Daver N. Distinct Immunophenotypes of T Cells in Bronchoalveolar Lavage Fluid From Leukemia Patients With Immune Checkpoint Inhibitors-Related Pulmonary Complications. Front Immunol 11:590494, 2020. e-Pub 2021. PMID: 33552049.
2. Kim ST, Bittar M, Kim HJ, Neelapu SS, Zurita AJ, Nurieva R, Suarez-Almazor ME. Recurrent pseudogout after therapy with immune checkpoint inhibitors: a case report with immunoprofiling of synovial fluid at each flare. J Immunother Cancer 7(1):126, 2019. e-Pub 2019. PMID: 31088575.
3. Liu X, Wang Y, Lu H, Li J, Yan X, Xiao M, Hao J, Alekseev A, Khong H, Chen T, Huang R, Wu J, Zhao Q, Wu Q, Xu S, Wang X, Jin W, Yu S, Wang Y, Wei L, Wang A, Zhong B, Ni L, Liu X, Nurieva R, Ye L, Tian Q, Bian XW, Dong C. Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature 567(7749):525-529, 2019. e-Pub 2019. PMID: 30814730.
4. Khosravi N, Caetano MS, Cumpian AM, Unver N, De la Garza Ramos C, Noble O, Daliri S, Hernandez BJ, Gutierrez BA, Evans SE, Hanash S, Alekseev AM, Yang Y, Chang SH, Nurieva R, Kadara H, Chen J, Ostrin EJ, Moghaddam SJ. IL22 Promotes Kras-Mutant Lung Cancer by Induction of a Protumor Immune Response and Protection of Stemness Properties. Cancer Immunol Res 6(7):788-797, 2018. e-Pub 2018. PMID: 29764837.
5. Na H, Lim H, Choi G, Kim BK, Kim SH, Chang YS, Nurieva R, Dong C, Chang SH, Chung Y. Concomitant suppression of TH2 and TH17 cell responses in allergic asthma by targeting retinoic acid receptor-related orphan receptor γt. J Allergy Clin Immunol 141(6):2061-2073, 2018. e-Pub 2017. PMID: 28943467.
6. Qin L, Waseem TC, Sahoo A, Bieerkehazhi S, Zhou H, Galkina EV, Nurieva R. Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology. Front Immunol 9:1884, 2018. e-Pub 2018. PMID: 30158933.
7. Taghavie-Moghadam PL, Waseem TC, Hattler J, Glenn LM, Dobrian AD, Kaplan MH, Yang Y, Nurieva R, Nadler JL, Galkina EV. STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice. J Immunol 199(10):3453-3465, 2017. e-Pub 2017. PMID: 29055004.
8. Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity. Cell Rep 21(1):195-207, 2017. PMID: 28978473.
9. Ritthipichai K, Haymaker CL, Martinez M, Aschenbrenner A, Yi X, Zhang M, Kale C, Vence LM, Roszik J, Hailemichael Y, Overwijk WW, Varadarajan N, Nurieva R, Radvanyi LG, Hwu P, Bernatchez C. Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter. Clin Cancer Res 23(20):6151-6164, 2017. e-Pub 2017. PMID: 28754817.
10. Cheekatla SS, Tripathi D, Venkatasubramanian S, Paidipally P, Welch E, Tvinnereim AR, Nurieva R, Vankayalapati R. IL-21 Receptor Signaling Is Essential for Optimal CD4+ T Cell Function and Control of Mycobacterium tuberculosis Infection in Mice. J Immunol 199(8):2815-2822, 2017. e-Pub 2017. PMID: 28855309.
11. Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, Singh D, Ritthipichai K, Hailemichael Y, Hoang ON, Qin H, Schluns KS, Wang T, Overwijk WW, Sun SC, Bernatchez C, Kwak LW, Neelapu SS, Nurieva R. Absence of Grail promotes CD8+ T cell anti-tumour activity. Nat Commun 8(1):239, 2017. e-Pub 2017. PMID: 28798332.
12. Venkatasubramanian S, Cheekatla S, Paidipally P, Tripathi D, Welch E, Tvinnereim AR, Nurieva R, Vankayalapati R. IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis. Mucosal Immunol 10(4):1031-1042, 2017. e-Pub 2016. PMID: 27924822.
13. Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem 58(22):8970-84, 2015. e-Pub 2015. PMID: 26506089.
14. Cao AT, Yao S, Gong B, Nurieva RI, Elson CO, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunol 8(5):1072-82, 2015. e-Pub 2015. PMID: 25586558.
15. Sahoo A, Alekseev A, Tanaka K, Obertas L, Lerman B, Haymaker C, Clise-Dwyer K, McMurray JS, Nurieva R. Batf is important for IL-4 expression in T follicular helper cells. Nat Commun 6:7997, 2015. e-Pub 2015. PMID: 26278622.
16. Tanaka S, Tanaka K, Magnusson F, Chung Y, Martinez GJ, Wang YH, Nurieva RI, Kurosaki T, Dong C. CCAAT/enhancer-binding protein α negatively regulates IFN-γ expression in T cells. J Immunol 193(12):6152-60, 2014. e-Pub 2014. PMID: 25398328.
17. Qin H, Lerman B, Sakamaki I, Wei G, Cha SC, Rao SS, Qian J, Hailemichael Y, Nurieva R, Dwyer KC, Roth J, Yi Q, Overwijk WW, Kwak LW. Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice. Nat Med 20(6):676-81, 2014. e-Pub 2014. PMID: 24859530.
18. Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature 507(7493):513-8, 2014. e-Pub 2014. PMID: 24463518.
19. Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade. Sci Signal 6(306):ra110, 2013. e-Pub 2013. PMID: 24345681.
20. Liu X, Nurieva RI, Dong C. Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev 252(1):139-45, 2013. PMID: 23405901.
21. Glasmacher E, Agrawal S, Chang AB, Murphy TL, Zeng W, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM, Singh H. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science 338(6109):975-80, 2012. e-Pub 2012. PMID: 22983707.
22. Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 209(10):1841-52, S1-24, 2012. e-Pub 2012. PMID: 22987803.
23. Ma Q, Li D, Nurieva R, Patenia R, Bassett R, Cao W, Alekseev AM, He H, Molldrem JJ, Kroll MH, Champlin RE, Sale GE, Afshar-Kharghan V. Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant 18(8):1174-81, 2012. e-Pub 2012. PMID: 22664751.
24. Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A 109(22):8664-9, 2012. e-Pub 2012. PMID: 22552227.
25. Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem 287(14):11234-9, 2012. e-Pub 2012. PMID: 22318729.
26. Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten AM, Dong C. Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity 36(1):23-31, 2012. e-Pub 2012. PMID: 22244845.
27. Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, Rawal S, Wang YH, Lim H, Reynolds JM, Zhou XH, Fan HM, Liu ZM, Neelapu SS, Dong C. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17(8):983-8, 2011. e-Pub 2011. PMID: 21785430.
28. Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem 286(26):22707-10, 2011. e-Pub 2011. PMID: 21566134.
29. Nurieva RI, Liu X, Dong C. Molecular mechanisms of T-cell tolerance. Immunol Rev 241(1):133-44, 2011. PMID: 21488895.
30. Nurieva RI, Chung Y. Understanding the development and function of T follicular helper cells. Cell Mol Immunol 7(3):190-7, 2010. e-Pub 2010. PMID: 20383172.
31. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity 32(5):670-80, 2010. e-Pub 2010. PMID: 20493730.
32. Reynolds JM, Pappu BP, Peng J, Martinez GJ, Zhang Y, Chung Y, Ma L, Yang XO, Nurieva RI, Tian Q, Dong C. Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity 32(5):692-702, 2010. e-Pub 2010. PMID: 20434372.
33. Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 10(12):1260-6, 2009. e-Pub 2009. PMID: 19881507.
34. Zhang Y, Reynolds JM, Chang SH, Martin-Orozco N, Chung Y, Nurieva RI, Dong C. MKP-1 is necessary for T cell activation and function. J Biol Chem 284(45):30815-24, 2009. e-Pub 2009. PMID: 19748894.
35. Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C. Bcl6 mediates the development of T follicular helper cells. Science 325(5943):1001-5, 2009. e-Pub 2009. PMID: 19628815.
36. Nurieva RI, Liu X, Dong C. Yin-Yang of costimulation: crucial controls of immune tolerance and function. Immunol Rev 229(1):88-100, 2009. PMID: 19426216.
37. Wang Y, Li D, Nurieva R, Yang J, Sen M, Carreño R, Lu S, McIntyre BW, Molldrem JJ, Legge GB, Ma Q. LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells. J Biol Chem 284(19):12645-53, 2009. e-Pub 2009. PMID: 19297325.
38. Liu X, Alexiou M, Martin-Orozco N, Chung Y, Nurieva RI, Ma L, Tian Q, Kollias G, Lu S, Graf D, Dong C. Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol 182(8):4516-20, 2009. PMID: 19342624.
39. Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87, 2009. e-Pub 2009. PMID: 19362022.
40. Nurieva R, Yang XO, Chung Y, Dong C. Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J Immunol 182(5):2565-8, 2009. PMID: 19234148.
41. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401, 2008. PMID: 19050256.
42. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49, 2008. e-Pub 2008. PMID: 18599325.
43. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56, 2008. e-Pub 2008. PMID: 18585065.
44. Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C. Regulation of inflammatory responses by IL-17F. J Exp Med 205(5):1063-75, 2008. e-Pub 2008. PMID: 18411338.
45. Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C. A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol 180(4):2276-83, 2008. PMID: 18250436.
46. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29-39, 2008. e-Pub 2007. PMID: 18164222.
47. Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol 179(2):1096-103, 2007. PMID: 17617602.
48. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448(7152):480-3, 2007. e-Pub 2007. PMID: 17581589.
49. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282(13):9358-63, 2007. e-Pub 2007. PMID: 17277312.
50. Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J 25(11):2623-33, 2006. e-Pub 2006. PMID: 16724117.
51. Yu XZ, Liang Y, Nurieva RI, Guo F, Anasetti C, Dong C. Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells. J Immunol 176(12):7394-401, 2006. PMID: 16751384.
52. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1133-41, 2005. e-Pub 2005. PMID: 16200068.
53. Nurieva RI. Regulation of immune and autoimmune responses by ICOS-B7h interaction. Clin Immunol 115(1):19-25, 2005. PMID: 15870016.
54. Dong C, Nurieva RI. Regulation of immune and autoimmune responses by ICOS. J Autoimmun 21(3):255-60, 2003. PMID: 14599850.
55. Nurieva RI, Mai XM, Forbush K, Bevan MJ, Dong C. B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A 100(24):14163-8, 2003. e-Pub 2003. PMID: 14615582.
56. Nurieva RI, Duong J, Kishikawa H, Dianzani U, Rojo JM, Ho Ic, Flavell RA, Dong C. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity 18(6):801-11, 2003. PMID: 12818161.
57. Dong C, Nurieva RI, Prasad DV. Immune regulation by novel costimulatory molecules. Immunol Res 28(1):39-48, 2003. PMID: 12947223.
58. Lepikhova TN, Navolotskaya EV, Zargarova TA, Nurieva RI, Lipkin VM, Zav'yalov VP. Influence of synthetic peptide corresponding to the ACTH-like sequence of human immunoglobulin G1 on proliferation of lymphoblastoid cells. Peptides 21(3):353-7, 2000. PMID: 10793216.
59. Navolotskaya EV, Zargarova TA, Lepikhova TN, Turobov VI, Nurieva RI, Malkova NV, Lipkin VM, Zav'yalov VP. Study of immunosuppressive activity of a synthetic decapeptide corresponding to an ACTH-like sequence of human immunoglobulin G1. Biochemistry (Mosc) 64(7):758-64, 1999. PMID: 10424898.
60. Nurieva RI, Navolotskaya EV, Lepikhova TN, Kostanyan IA, Lipkin VM. A Study of L-Glutamate Binding on Murine Peritoneal Macrophages and Its Influence on the Activity of These Cells. Russ J Immunol 3(3-4):270-273, 1998. PMID: 12687106.
61. Kostanian IA, Nurieva RI, Lepikhova TN, Astapova MV, Navolotskaia EV, Zavialov VP, Lipkin VM. [Appearance of glutamate receptors on the surface of HL-60 cells upon differentiation]. Bioorg Khim 24(6):468-70, 1998. PMID: 9702357.
62. Kostanyan IA, Nurieva RI, Navolotskaya EV, Astapova MV, Dranitsina SM, Bogachuk AP, Zav'yalov VP, Lipkin VM. Influence of L-glutamic acid on binding of interleukin-1beta, tumour necrosis factor-alpha and interleukin-6 to HL-60 cells. Immunol Lett 62(1):9-13, 1998. PMID: 9672141.
63. Kostanian IA, Nurieva RI, Novolotskaia EV, Astapova MV, Dranitsyna SM, Zav'ialov VP, Lipkin VM. [Effect of L-glutamic acid on the reception of cytokines by HL-60 cells]. Bioorg Khim 24(1):3-9, 1998. PMID: 9551194.
64. Kostanian IA, Nurieva RI, Navolotskaia EV, Astapova MV, Dranitsyna SM, Zav'ialov VP, Lipkin VM. [Mechanism of differentiating action of L-glutamic acid on HL-60 cells]. Mol Biol (Mosk) 32(1):148-53, 1998. PMID: 9566262.
65. Kostanyan IA, Navolotskaya EV, Nurieva RI, Zav'ialov VP, Lipkin VM. [Interaction of L-glutamic acid with human T-lymphocytes]. Bioorg Khim 23(10):805-8, 1997. PMID: 9490616.
66. Kostanyan IA, Merkulova MI, Navolotskaya EV, Nurieva RI. Study of interaction between L-glutamate and human blood lymphocytes. Immunol Lett 58(3):177-80, 1997. PMID: 9293400.
67. Kostanyan IA, Navolotskaya EV, Nurieva RI. Identification of Binding Sites for L-Glutamate on T Lymphocytes. Russ J Immunol 2(2):135-137, 1997. PMID: 12687068.
68. Abdrasilov BS, Kim YuA , Nurieva RI, Dedkova EN, Leonteva GA, Park HJ, Zinchenko VP. The effect of total saponins from Panax Ginseng C.A. Meyer on the intracellular signalling system in Ehrlich ascites tumor cells. Biochem Mol Biol Int 38(3):519-26, 1996. PMID: 8829611.

Book Chapters

1. Martinez GJ, Nurieva RI, Yang XO, Dong C. Regulation and function of proinflammatory TH17 cells. In: Ann N Y Acad Sci. Wiley: New York, 188-211, 2008.
2. Dong C, Nurieva RI, Martin-Orozco N. Immune regulation and immunotherapy of autoimmune disease. In: Costimulation Regulation of Immune Tolerance and Autoimmunity. Springer US, Life Sciences, 121-138, 2007.
3. Dong C, Chang S, Yang X, Nurieva R. Inflammatory T cells: regulation, function and pathological roles in disease. In: Effector CD4 T Cell Subsets in Health and Disease. Research Signpost, 65-84, 2007.