Skip to Content

'
S. Cheenu Kappadath, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Faculty, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX

Bio Statement

S. Cheenu Kappadath, PhD, is an Associate Professor in the Department of Imaging Physics. He is a board-certified and licensed medical physicist with specialties in Nuclear Medicine Physics and Instrumentation (ABSNM) and Diagnostic Radiologic Physics (ABR). He provides clinical physics support for the Departments of Nuclear Medicine and Diagnostic Radiology in the Division of Diagnostic Imaging. He is the Program Director for Imaging Physics Network Services and oversees clinical Imaging Physics operations at institutions within the MD Anderson Cancer Network as well as other satellite and regional care facilities.

He is actively involved in a variety of funded research projects in SPECT/CT, PET/CT, and CT and is the recipient of grants from NIH and industry. Topics of research focus include liver-directed Yttrium-90 microsphere therapy, molecular breast imaging, quantitative imaging with SPECT, PET, and CT; and patient-specific voxel dosimetry. Dr. Kappadath also holds a joint Associate Faculty appointment at The University of Texas Graduate School of Biomedical Sciences in Houston where he serves as an instructor in various courses and advisor to medical physics graduate students. Dr. Kappadath is an active member of several professional medical physics societies such as the AAPM, SNMMI, and ACR. More recently, his research has received the Arthur Weis Award in Radiation Dosimetry and Safety from the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

Research Interests

His research interests are focused on Nuclear Medicine physics with specific emphasis on developing quantitative imaging to aid in the diagnosis and managements of cancer patients. Areas of specialization include:

·        Liver-directed Yttrium-90 microsphere therapy

·        Molecular breast imaging (MBI)

·        Quantitative imaging with SPECT/CT, PET/CT, and DE-CT

·        Novel algorithms for patient-specific voxel dosimetry

A strong interest lies in improving all aspects of liver-directed Yttrium-90 microsphere therapy from improving patient imaging for therapy planning to quantifying post-therapy imaging to measure tumor dose and evaluate response. His research lab is looking at novel algorithms for patient-specific voxel dosimetry and its application to determine the tumor dose-response and toxicities following Yttrium-90 microsphere therapy. Research is also conducted in quantifying radionuclide uptake in breast cancers with MBI and assessing its capability as an indicator to tumor response following chemotherapy.

Clinical Interests

 ·       Work with radiologists to improve diagnostic image quality for routine clinical imaging

·        Clinical implementation of innovations in data acquisition and image generation

·        Manage clinical imaging physics activities at Partner Institutions and Regional Care Centers

Education & Training

Degree-Granting Education

1998 University of New Hampshire, Durham, NH, PhD, Physics
1994 University of New Hampshire, Durham, NH, MS, Physics
1991 Illinois Wesleyan University, Bloomington, IL, BA, Physics and Mathematics

Postgraduate Training

1/2006-10/2007 Clinical Residency, Medical Physics, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
9/1998-3/2001 Postdoctoral Research Scientist, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA

Board Certifications

6/2008 American Board of Radiology, Diagnostic Radiologic Physics
6/2007 American Board of Science in Nuclear Medicine, Nuclear Medicine Physics and Instrumentation

Experience/Service

Academic Appointments

Assistant Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 10/2007-7/2014

Administrative Appointments/Responsibilities

Member, Imaging Physics Clinical Operations Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-present
Nuclear Medicine Research Peer-Review Committee, Member, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-present

Other Appointments/Responsibilities

Coordinator, Outreach Clinical Physics Operations, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013-present
Lead Imaging Physicist, Banner MD Anderson Cancer Center, Phoenix, AZ, 2011-present

Institutional Committee Activities

MD Anderson Cancer Network, Clinical Consultant, 2012-present

Honors and Awards

2015 3rd Place Award Oncology Clinical Diagnosis Track Poster Presentation, Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variablility in partition model absorbed doses following Y90 microsphere therapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2015 Arthur Weis Award in Radiation Dosimetry and Safety, Mikell J. Jahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variablility in partition model absorbed doses following Y90 microsphere therapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2014 Volunteer Service Award, American Board of Radiology
2012 2nd Place Award Radiopharmacy Track Poster Presentation, Maclellan C, Hobbs BP, Chasen B, Murthy R, Mahvash A, Kappadath SC. Absorbed dose differences in 90Y microsphere therapy between pre-treatment 99mTc-MAA and post-treatment 90Y scans, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2012 2nd Place Award Technologist Oral Presentation, Gonzalez JA, McCoy AP, Mar MV, Kappadath SC. Identifying optimal SPECT acquisition for liver imaging using 99mTc-MAA, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2007 Reviewer's Choice Oral Presentation Award, Kappadath SC, Wendt RE. Assessment of the radiation shielding for a busy PET/CT facility, AAPM Annual Meeting, Washington, DC
2007 Trainee Travel Grant Recipient, IEEE Medical Imaging Conference, Honolulu, Hawaii
2006-2008 Medical Physics Residency Award, Radiological Society of North America
2004 Honorable Mention Poster Award, Kappadath SC, Shaw C, Lai CJ, Liu X, Whitman G., Dual-energy digital mammography for calcification imaging: theory and implementation, SPIE Physics of Medical Imaging Symposium, San Diego, CA
1991 Cum laude, B.A, Illinois Wesleyan University, Bloomington, Illinois
1991 Meritorious Award, Mathematical Contest in Modeling, Illinois Wesleyan University, Bloomington, Illinois

Professional Memberships

American Association of Physicists in Medicine (AAPM)
Member, AAPM Task Group 177: Gamma Camera, SPECT, and SPECT/CT Acceptance Testing and Annual Surveys, 2009-present
Member, Nuclear Medicine Subcommittee, 2009-present
The Society of Nuclear Medicine and Molecular Imaging (SNMMI)
Member, Computer and Instrumentation Council, 2009-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Hulme KW, Kappadath SC. Implications of CT noise and artifacts for quantitative (99m)Tc SPECT/CT imaging. Med Phys 41(4):042502, 4/2014. PMID: 24694155.
2. Silosky M, Johnson V, Beasley C, Kappadath SC. Characterization of the count rate performance of modern gamma cameras. Med Phys 40(3):032502, 3/2013. PMCID: PMC3829891.
3. Siman W, Kappadath SC. Performance characteristics of a new pixelated portable gamma camera. Med Phys 39(6):3435-3444, 6/2012. PMCID: PMC3829890.
4. Mathieu KB, Kappadath SC, White RA, Atkinson EN, Cody DD. An empirical model of diagnostic x-ray attenuation under narrow-beam geometry. Med Phys 38(8):4546-4555, 8/2011. PMCID: PMC3155576.
5. Hulme KW, Rong J, Chasen B, Chuang HH, Cody DD, Wong FC, Kappadath SC. A CT acquisition technique to generate images at various dose levels for prospective dose reduction studies. Am J Roentgenol 196(2):W144-51, 2/2011. PMID: 21257855.
6. Kappadath SC. Effects of voxel size and iterative reconstruction parameters on the spatial resolution of 99mTc SPECT/CT. J Appl Clin Med Phys 12(4):3459, 2011. e-Pub 11/15/2011. PMID: 22089002.
7. Kappadath SC, Erwin WD, Wendt RE. A novel method to evaluate gamma camera rotational uniformity and sensitivity variation. Med Phys 36(6):1947-1955, 6/2009. PMID: 19610283.
8. Kappadath SC, Shaw CC. Dual-energy digital mammography: noise reduction techniques. Phys Med Bio 53:5421-43, 2008.
9. Mawlawi O, Kappadath SC, Pan T, Macapinlac H. Factors affecting quantification in PET/CT imaging. Current Medical Imaging Reviews 4, 2008.
10. Kappadath SC, Erwin WD, Wendt RE. Observed intercamera variability in clinically relevant performance characteristics for Siemens Symbia gamma cameras. Journal of Applied Clinical Medical Physics 7(4), 2006.
11. Kappadath SC, Shaw CC. Dual-energy digital mammography for calcification imaging: scatter and nonuniformity corrections. Med Phys 32(11):3395-408, 2005. PMID: 16372415.
12. Lai CJ, Shaw CC, Whitman GJ, Johnston DA, Yang WT, Selinko V, Arribas E, Dogan B, Kappadath SC. Visibility of simulated microcalcifications-a hardcopy-based comparison of three mammographic systems. Med Phys 32(1):182-94, 2005. PMID: 15719969.
13. Kappadath SC, Shaw CC. Quantitative evaluation of dual-energy digital mammography for calcification imaging. Phys Med Biol 49:2563-76, 2004. PMID: 15272674.
14. Kappadath SC, Shaw CC. Dual-energy digital mammography: calibration and inverse-mapping techniques to estimate calcification thickness and glandular-tissue ratio. Med Phys 30(6):1110-7, 2003. PMID: 12852535.
15. Lemacks MR, Kappadath SC, Shaw CC, Liu X, Whitman GJ. A dual-energy subtraction technique for microcalcification imaging in digital mammography: a signal-to-noise analysis. Med Phys 29(8):1739-51, 2002. PMID: 12201421.

Grant & Contract Support

Title: Develop methodology to separately compute the trabecular and cortical bone-mineral density using the GE Discovery CT 750HD scanner with GSI
Funding Source: General Electric
Role: Principal Investigator
Duration: 2/1/2013 - 3/31/2014
 
Title: A novel dose calculation method for targeted radionuclide therapy
Funding Source: Christiana Care Health Services/NIH
Role: Principal Investigator
Duration: 8/1/2012 - 7/31/2015
 
Title: Multi-modal reconstruction and quantitative SPECT imaging
Funding Source: Siemens Medical Solutions
Role: Co-Investigator
Principal Investigator: Homer Macapinlac, M.D.
Duration: 1/15/2012 - 10/31/2015

Last updated: 7/21/2015