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Sai-Ching J Yeung, BS, R Ph, MS, Ph D, MD, FACP

Present Title & Affiliation

Primary Appointment

Professor, Department of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Adjunct Professor, Department of Internal Medicine, The University of Texas Medical School, Houston, TX
Adjunct Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Adjunct Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, The University of Houston, College of Pharmacy, Houston
Adjunct Professor, Texas A&M Health Science Center, Houston, TX
Adjunct Professor, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX

Education & Training

Degree-Granting Education

1991 St. Louis University, School of Medicine, St. Louis, MO, Doctor of Medicine, Medicine
1988 University of Houston, College of Natural Sciences and Mathematics, Houston, TX, Doctor of Philosophy, Biology
1985 University of Houston, College of Natural Sciences and Mathematics, Houston, TX, Master of Science, Biology
1983 University of Houston, College of Pharmacy, Houston, TX, Bachelor of Science, Magna Cum Laude, Pharmacy

Board Certifications

8/1994 American Board of Internal Medicine, Recertification Date: 9/2014
10/1997 American Board of Internal Medicine, Subspecialty Board in Endocrinology and Metabolism, Recertification Date: 1/2008

Experience/Service

Academic Appointments

Associate Professor, Department of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2010-8/2013
Associate Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2006-8/2013

Administrative Appointments/Responsibilities

Deputy Chief, Section of Emergency Care, Department of General Internal Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2002-8/2010

Institutional Committee Activities

Member, Faculty Senate, 9/2013-present

Honors and Awards

2013 US Faculty Scholar 2013, Vietnam Education Foundation

Selected Publications

Peer-Reviewed Original Research Articles

1. Cheng C, Deng ZS, Yeung SC, Fan L, Liu ZG, Hong JM. Bilateral Pulmonary Artery Aneurysms, Coronary Artery Aneurysm and Ventricular Pseudoaneurysm in Behcet’s Disease. BMC Cardiovascular Disorders. In Press.
2. Bankson JA, Walker CM, Ramirez MS, Stefan W, Fuentes D, Merritt ME, Lee J, Sandulache VC, Chen Y, Phan L, Chou PC, Rao A, Yeung SC, Lee MH, Schellingerhout D, Conrad CA, Malloy C, Sherry AD, Lai SY, Hazle JD. Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors. Cancer Res 75(22):4708-17, 11/15/2015. e-Pub 9/29/2015. PMCID: PMC4651725.
3. Phan LM, Fuentes-Mattei E, Wu W, Velazquez-Torres G, Sircar K, Wood CG, Hai T, Jimenez C, Cote GJ, Ozsari L, Hofmann MC, Zheng S, Verhaak R, Pagliaro L, Cortez MA, Lee MH, Yeung SC, Habra MA. Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. Cancer Res 75(19):4131-42, 10/1/2015. e-Pub 8/17/2015. PMCID: PMC4592476.
4. Gao S, Fang L, Phan LM, Qdaisat A, Yeung SC, Lee MH. COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer. Oncotarget 6(29):28026-41, 9/29/2015. PMID: 26318036.
5. Choi HH, Phan L, Chou PC, Su CH, Yeung SC, Chen JS, Lee MH. COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth. Oncotarget 6(23):19721-34, 8/14/2015. PMID: 26254224.
6. Fang L, Lu W, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Chen C, Wang L, Wang J, Lee MH. ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development. Cancer Cell 28(2):183-97, 8/10/2015. PMID: 26267535.
7. Zhou DS, Wang HB, Zhou ZG, Zhang YJ, Zhong Q, Xu L, Huang YH, Yeung SC, Chen MS, Zeng MS. TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma. Oncotarget. e-Pub 6/25/2015. PMID: 26219398.
8. Dasari A, Phan A, Gupta S, Rashid A, Yeung SC, Hess K, Chen H, Tarco E, Chen H, Wei C, Anh-Do K, Halperin D, Meric-Bernstam F, Yao J. Phase I study of the anti-IGF1R antibody cixutumumab with everolimus and octreotide in advanced well-differentiated neuroendocrine tumors. Endocr Relat Cancer 22(3):431-41, 6/2015. e-Pub 4/21/2015. PMID: 25900182.
9. Choi HH, Su CH, Fang L, Zhang J, Yeung SC, Lee MH. CSN6 deregulation impairs genome integrity in a COP1-dependent pathway. Oncotarget 6(14):11779-93, 5/20/2015. PMCID: PMC4494904.
10. Li Z, Zou X, Xie L, Chen H, Chen Y, Yeung SC, Zhang H. Personalizing risk stratification by addition of PAK1 expression to TNM staging: improving the accuracy of clinical decision for gastroesophageal junction adenocarcinoma. Int J Cancer 136(7):1636-45, 4/2015. e-Pub 9/2014. PMID: 25159681.
11. Wu W, Liu X, Chaftari P, Cruz Carreras MT, Gonzalez C, Viets-Upchurch J, Merriman K, Tu SM, Dalal S, Yeung SC. Association of body composition with outcome of docetaxel chemotherapy in metastatic prostate cancer: a retrospective review. PLoS One 10(3):e0122047, 2015. e-Pub 3/30/2015. PMCID: PMC4379069.
12. Reyes-Gibby CC, Yuan C, Wang J, Yeung SC, Shete S. Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. BMC Syst Biol 9:25, 2015. e-Pub 6/5/2015. PMCID: PMC4456775.
13. Reyes-Gibby CC, Wang J, Yeung SC, Shete S. Informative gene network for chemotherapy-induced peripheral neuropathy. BioData Min 8:24, 2015. e-Pub 8/12/2015. PMCID: PMC4534051.
14. Bilen MA, Lin SH, Tang DG, Parikh K, Lee MH, Yeung SC, Tu SM. Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series. Case Rep Oncol Med 2015:471861, 2015. e-Pub 3/15/2015. PMCID: PMC4377453.
15. Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. Nat Commun 6:7530, 2015. e-Pub 7/16/2015. PMCID: PMC4507299.
16. Pérez CM, Ortiz AP, Fuentes-Mattei E, Velázquez-Torres G, Santiago D, Giovannetti K, Bernabe R, Lee MH, Yeung SC. High Prevalence of Cardiometabolic Risk Factors in Hispanic Adolescents: Correlations with Adipocytokines and Markers of Inflammation. J Immigr Minor Health 16(5):865-73, 10/2014. e-Pub 7/2013. PMCID: PMC3883942.
17. Bazerbashi H, Merriman KW, Toale KM, Chaftari P, Cruz Carreras MT, Henderson JD, Yeung SC, Rice TW. Low tissue oxygen saturation at emergency center triage is predictive of intensive care unit admission. J Crit Care 29(5):775-9, 10/2014. e-Pub 5/27/2014. PMID: 24973103.
18. Li X, Zhang Y, Yeung SC, Liang Y, Liang X, Ding Y, Ip MS, Tse HF, Mak JC, Lian Q. Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke-induced damage. Am J Respir Cell Mol Biol 51(3):455-65, 9/2014. PMID: 24738760.
19. Wu W, Merriman K, Nabaah A, Seval N, Seval D, Lin H, Wang M, Qazilbash MH, Baladandayuthapani V, Berry D, Orlowski RZ, Lee MH, Yeung SC. The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma. Br J Cancer 111(3):628-36, 7/29/2014. e-Pub 6/12/2014. PMCID: PMC4119980.
20. Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst 106(7), 7/2014. e-Pub 6/23/2014. PMCID: PMC4110474.
21. Phan LM, Yeung SC, Lee MH. Cancer Metabolic Reprogramming: Importance, Main Features, and Potentials for Precise Targeted Anti-Cancer Therapies. Cancer Biol Med 11(1):1-19, 3/2014. PMCID: PMC3969803.
22. Tudor S, Giza DE, Lin HY, Fabris L, Yoshiaki K, D'Abundo L, Toale KM, Shimizu M, Ferracin M, Challagundla KB, Cortez MA, Fuentes-Mattei E, Tulbure D, Gonzalez C, Henderson J, Row M, Rice TW, Ivan C, Negrini M, Fabbri M, Morris JS, Yeung SC, Vasilescu C, Calin GA. Cellular and Kaposi's sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma. Cell Death Dis 5:e1559, 2014. e-Pub 12/4/2014. PMID: 25476907.
23. Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun 5:5384, 2014. e-Pub 11/14/2014. PMCID: PMC4234183.
24. Ost DE, Yeung SC, Tanoue LT, Gould MK. Clinical and organizational factors in the initial evaluation of patients with lung cancer: Diagnosis and management of lung cancer, 3rd Edition: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143(5 Suppl):e121S-41S, 5/2013. PMID: 23649435.
25. Zhao R, Yang HY, Shin J, Phan L, Fang L, Che TF, Su CH, Yeung SC, Lee MH. CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity. Cell Cycle 12(6):935-43, 3/15/2013. e-Pub 2/19/2013. PMCID: PMC3637352.
26. Hanzelka KM, Yeung SC, Chisholm G, Merriman KW, Gaeta S, Malik I, Rice TW. Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center. Support Care Cancer 21(3):727-34, 3/2013. e-Pub 9/7/2012. PMID: 22956191.
27. Yeung SC, Elsayem A, Fuller GN, Lu G, You MJ. Fatal acute monocytic leukemia with t(6;11)(q27;q23) translocation and KRAS mutation. J Clin Pathol 66(1):73-5, 1/2013. e-Pub 10/2012. PMID: 22923764.
28. Esteva FJ, Moulder SL, Gonzalez-Angulo AM, Ensor J, Murray JL, Green MC, Koenig KB, Lee MH, Hortobagyi GN, Yeung SC. Phase I trial of exemestane in combination with metformin and rosiglitazone in nondiabetic obese postmenopausal women with hormone receptor-positive metastatic breast cancer. Cancer Chemother Pharmacol 71(1):63-2, 1/2013. e-Pub 9/28/2012. PMCID: PMC3536885.
29. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol 13:67, 2013. e-Pub 4/2013. PMCID: PMC3637159.
30. Luo Y, Yang C, Ye M, Jin C, Abbruzzese JL, Lee MH, Yeung SC, McKeehan WL. Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations. Cancer Metab 1(1):21, 2013. e-Pub 11/2013. PMID: 24279986.
31. Wen YY, Chou PC, Phan L, Su CH, Chen J, Hsieh YC, Xue YW, Qu CJ, Gully C, Parreno K, Teng C, Hsu SL, Yeung SC, Wang HM, Lee MH. DNA damage-mediated c-Myc degradation requires 14-3-3 sigma. Cancer Hallmarks 1:3-17, 2013.
32. Chen B, Zhao R, Su CH, Linan M, Tseng C, Phan L, Fang L, Yang HY, Yang H, Wang W, Xu X, Jiang N, Cai S, Jin F, Yeung SC, Lee MH. CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6. Cell Cycle 11(24):4633-41, 12/15/2012. e-Pub 11/27/2012. PMCID: PMC3562308.
33. Luo CQ, Yeung SC, Liu ZG, Meng J, Zhong FT, Cheng C. Pulmonary well-differentiated fetal adenocarcinoma with platelet-derived growth factor receptor (PDGFR)α expression. Cancer Biol Ther 13(14):1384-89, 12/2012. e-Pub 9/2012. PMID: 22986233.
34. Teng CL, Hsieh YC, Phan L, Shin J, Gully C, Velazquez-Torres G, Skerl S, Yeung SC, Hsu SL, Lee MH. FBXW7 is involved in Aurora B degradation. Cell Cycle 11(21):4059-68, 11/1/2012. e-Pub 10/24/2012. PMCID: PMC3507501.
35. Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle 11(22):4181-90, 11/15/2012. e-Pub 10/24/2012. PMID: 23095642.
36. Vu K, Busaidy N, Cabanillas ME, Konopleva M, Faderl S, Thomas DA, O'Brien S, Broglio K, Ensor J, Escalante C, Andreeff M, Kantarjian H, Lavis V, Yeung SC. A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk 12(5):355-62, 10/2012. e-Pub 6/1/2012. PMID: 22658895.
37. Tu SM, Som A, Tu B, Logothetis CJ, Lee MH, Yeung SC. Effect of Paget's disease of bone (osteitis deformans) on the progression of prostate cancer bone metastasis. Br J Cancer 107(4):646-51, 8/7/2012. e-Pub 7/17/2012. PMCID: PMC3419961.
38. He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol 23(7):1771-80, 7/2012. e-Pub 11/22/2011. PMCID: PMC3387820.
39. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A 109(24):E1513-22, 6/12/2012. e-Pub 5/18/2012. PMCID: PMC3386093.
40. Pan J, Chen C, Jin Y, Fuentes-Mattei E, Velazquez-Torres G, Benito JM, Konopleva M, Andreeff M, Lee MH, Yeung SC. Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells. Cell Cycle 11(12):2314-26, 6/2012. e-Pub 6/2012. PMCID: PMC3383592.
41. Sadeghi N, Abbruzzese JL, Yeung SC, Hassan M, Li D. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin Cancer Res 18(10):2905-12, 5/15/2012. e-Pub 3/31/2012. PMCID: PMC3381457.
42. Wu Y, Chen C, Sun X, Shi X, Jin B, Ding K, Yeung SC, Pan J. Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells. Clin Cancer Res 18(7):1966-78, 4/2012. e-Pub 3/2012. PMID: 22447844.
43. Matthias N, Lockworth CR, Zhang F, Lee MH, Yeung SC, Tsai KY, Hamir AN. Multiple cystic sweat gland tumors in transgenic mice. Comp Med 62(1):27-30, 2/2012. PMCID: PMC3276389.
44. Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ. Oncogene 30(48):4791-801, 12/2011. e-Pub 5/2011. PMCID: PMC3358116.
45. Liu Z, Feng H, Yeung SC, Zheng Z, Liu W, Ma J, Zhong FT, Luo H, Cheng C. Extended transsternal thymectomy for the treatment of ocular myasthenia gravis. Ann Thorac Surg 92(6):1993-9, 12/2011. PMID: 22115207.
46. He XX, Tu SM, Lee MH, Yeung SC. Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients. Ann Oncol 22(12):2640-5, 12/2011. e-Pub 3/17/2011. PMCID: PMC3221513.
47. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med 15(4):825-36, 4/2011. e-Pub 5/2010. PMCID: PMC2930937.
48. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121(3):851-65, 3/2011. e-Pub 2/7/2011. PMCID: PMC3049400.
49. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res 71(3):884-94, 2/2011. e-Pub 12/2010. PMCID: PMC3358120.
50. Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Exenatide improves glucocorticoid-induced glucose intolerance in mice. Diabetes Metab Syndr Obes 4:61-5, 2011. e-Pub 1/26/2011. PMCID: PMC3064408.
51. Hanzelka KM, Zalpour A, Afshar-Kharghan V, Fitousis K, Anderlini P, Yeung SC. Severe thrombosis and acute thrombocytopenia in a cancer patient. Am J Hematol 85(11):887-90, 11/2010. PMID: 20721891.
52. Su CH, Zhao R, Velazquez-Torres G, Chen J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3-3s in response to DNA damage. Mol Cancer 9:243, 9/2010. e-Pub 9/2010. PMCID: PMC2949799.
53. Chen B, Liu C-G, Jin F, Sun Y-N, Zhao T-T, Zhang L-N, Li S, Yeung SC. The role of fine-wire localization breast biopsy in the management of BI-RADS category 3-5 non-palpable breast lesions in northeastern Chinese women. Health 2(4):291-294, 4/2010.
54. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer 9:42, 2010. e-Pub 2/22/2010. PMCID: PMC2839967.
55. Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res 12(6):R96, 2010. e-Pub 11/16/2010. PMCID: PMC3046439.
56. Cheng C, Wu G, Yeung SC, Li R, Bella AE, Pang J, Zhong FT, Luo H, Jin Y, Pan J. Serum protein profiles in myasthenia gravis. Ann Thorac Surg 88(4):1118-23, 10/2009. PMID: 19766792.
57. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic Therapies Affect Risk of Pancreatic Cancer. Gastroenterology 137(2):482-8, 8/2009. e-Pub 4/16/2009. PMCID: PMC2735093.
58. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation. Am J Pathol 175(1):400-11, 7/2009. e-Pub 6/2009. PMCID: PMC2708825.
59. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene 28(28):2581-92, 7/2009. e-Pub 6/2009. PMCID: PMC3358117.
60. Pan J, Song E, Cheng C, Lee MH, Yeung SC. Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms? Autophagy 5(1). e-Pub 1/4/2009. PMID: 19066466.

Invited Articles

1. Yeung SCJ, Habra M. PTHLH (Parathyroid hormone-like hormone). Atlas Genet Cytogenet Oncol Haematol(17):94(1), 2013.
2. Yeung SCJ, Habra M. Thyroid: Anaplastic (undifferentiated) carcinoma. Atlas Genet Cytogenet Oncol Haematol(16):935(9), 2013.
3. Lee MH, Zhao R, Phan L, Yeung SC. Roles of COP9 signalosome in cancer. Cell Cycle 10(18):3057-66, 9/15/2011. e-Pub 9/15/2011. PMCID: PMC3218617.
4. Yeung SC, Habra MA, Thosani SN. Lung cancer-induced paraneoplastic syndromes. Curr Opin Pulm Med 17(4):260-8, 7/2011. PMID: 21577115.
5. Lee MH, Yeung SC. Intercepting Akt with DNAzyme: A nasopharyngeal carcinoma story. Cancer Biol Ther 8(4). e-Pub 2/2009. PMID: 19182540.
Other Articles
1. Yeung SC, Habra MA, Thosani SN. Lung cancer-induced paraneoplastic syndromes. Curr Opin Pulm Med 17(4):260-8, 2011. e-Pub 2011. PMID: 21577115.

Abstracts

1. Elsayem A, Merriman K, Gonzalez C, Yeung SC, Chaftari P, Henderson J, Todd KH. Intensive Care Unit Admissions and Mortality in Patients admitted through the Emergency Department of a Comprehensive Cancer Center. Proceedings of ASCO 2014, 2014.
2. Tu SM, Bilen MA, Tu ZH, General R, Ward JF, Pisters LL, General R, Chen AH, Nieto Y, Pagliaro LC, Yeung SJ, Logothetis C, Lin SH, Gorlov I. Nonseminomatous germ cell tumor of the testis: Prognostic factors for a lethal phenotype. 2014 Genitourinary Cancers Symposium, 2014.
3. Chou PC, Zhao R, Fuentes-Mattei E, Velazquez-Torre G, Zhang F, Qu C, Phan L, Lee J, Elliott A, Bankson JA, Wu Y, Wang H, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Anti-insulin resistance treatments suppress breast cancer growth and alter metabolic status. DoIM Research Retreat, 6/2013.
4. Shin J, Yang TY, Chou PC, Phan L, Chen J, Vázquez Vélez GE, Yeung SC, Lee MH. COP1 ubiquitin ligase Regulates FBW7 stability in a AKT dependent manner. DoIM Research Retreat, 6/2013.
5. Fuentes-Mattei E, Phan L, Velazquez-Torres G, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Gully C, Carlock C, Zhao R, Qi Y, Zhang Y, Wu Y, Esteva FJ, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee MH, Yeung SC. Obesity Induces Functional Transcriptomic Changes in Estrogen Receptor-Positive Breast Cancer. DoIM Research Retreat, 6/2013.
6. Fuentes-Mattei E, Zhang F, Velazquez-Torres G, Chou PC, Phan L, Shin JH, Choi HH, Chen JS, Gully C, Colin C, Zhao R, Wu Y, Esteva FJ, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee MH, Yeung SC. Obesity Accelerates Oncogene-Driven Estrogen Receptor-Positive Breast Carcinogenesis, Coincident with Changes in Tumor Metabolism and Enhanced Epithelial-Mesenchymal Transition Gene Expression. Keystone Symposia X4 Tumor Metabolism Keystone, Colorado, 2013.
7. Fuentes-Mattei E, Phan L, Velazquez-Torres G, Zhang F, Chou PC, Phan L, Shin JH, Choi HH, Chen JS, Gully C, Colin C, Zhao R, Wu Y, Esteva FJ, Lou Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee MH, Yeung SC. Obesity Induces Functional Transcriptomic Changes Enhancing the Cancer Hallmarks of ER-Positive Breast Cancer. 2013 Gordon Research Seminar (GRS)/ Gordon Research Conference (GRC) Cellular & Molecular Mechanism of Toxicology, 2013.
8. Fuentes-Mattei E, Phan L, Velazquez-Torres G, Zhang F, Chou PC, Phan L, Shin JH, Choi HH, Chen JS, Gully C, Colin C, Zhao R, Wu Y, Esteva FJ, Lou Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee MH, Yeung SC. Obesity Induces Functional Transcriptomic Changes Enhancing the Cancer Hallmarks of ER-Positive Breast Cancer. 2013 San Antonio Breast Cancer Symposium (#1629), 2013.
9. Fuentes-Mattei E, Phan L, Velazquez-Torres G, Zhang F, Chou PC, Phan L, Shin JH, Choi HH, Chen JS, Gully C, Colin C, Zhao R, Wu Y, Esteva FJ, Lou Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee MH, Yeung SC. Obesity Induces Functional Transcriptomic Changes Enhancing the Cancer Hallmarks of ER-Positive Breast Cancer. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, 2013.
10. Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YW, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Lin X, Wang HA, Wang H, Zhang A, Xia X, Wu Y, Yang W, Pusztai L, Yeung SC, Lee MH. 14-3-3sigma regulates cancer metabolic reprogramming by targeting c-Myc. Proceedings of Cell Symposium Hallmarks of Cancer, 10/2012.
11. Elsayem AF, Gonzalez CE, Yeung SC, Merriman K, Todd KH. In-hospital mortality of patients admitted through the emergency department of a comprehensive cancer center. ASCO Annual Meeting, Chicago, IL (#6125), 6/2012.
12. Fuentes-Mattei E, Gully C, Velazquez-Torres G, Shin JH, Chen JS, Choi HH, Chou PC, Adams HP, Phan L, Yang TY, Yeung SC, Lee MH. Aurora B binds p53 during both interphase and mitosis, phosphorylates it and promotes its degradation. Division of Internal Medicine Retreat, MD Anderson Cancer Center, 5/2012.
13. Fuentes-Mattei E, Gully C, Velazquez-Torres G, Shin JH, Chen JS, Choi HH, Chou PC, Adams HP, Phan L, Yang TY, Yeung SC, Lee MH. Aurora B binds p53 during both interphase and mitosis, phosphorylates it and promotes its degradation. Late-Breaking Research: Molecular and Cellular Biology 4, AACR Annual Meeting, Chicago, IL, 4/2012.
14. Luo Y, Yang C, Lee MH, Yeung SC, McKeehan WL. Deficiency of Metabolic Regulator FGFR4 Elevates Endocrine FGF19 and FGF21 and Suppresses TGFa-driven Breast Cancer Progression. 3rd International Conference on Fibroblast Growth Factors. Wenzhou, China, 2012.
15. Fuentes-Mattei E, Zhang F, Velazquez-Torres G, Chou PC, Phan L, Shin JH, Choi HH, Chen JS, Gully C, Carlock C, Zhao R, Wu Y, Esteva FJ, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee MH, Yeung SC. Obesity accelerates oncogene-driven estrogen receptor-positive breast carcinogenesis and cancer progression with enhanced glycolysis and epithelial–mesenchymal transition. Jackson Lab's 21th Annual Short Course on Experimental Model of Human Cancer, 2012.
16. Phan L, Chou PC, Samudio I, Velazquez-Torres G, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng X, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Yang W, Pusztai L, Yeung SC, Lee MH. The tumor suppressor 14-3-3sigma is a new regulator of cancer metabolism. Award Finalist - Basic Science Research, MD Anderson Cancer Center Trainee Research Day, 2012.

Book Chapters

1. Liu W, Yeung SC. Metabolic and Endocrine Oncologic Emergencies. In: Oncologic Emergencies, 1st Edition. Ed(s) Manzullo EF, Gonzalez CE, Escalante CP, Yeung, SC. Springer-Verlag New York, 2016.
2. Yeung SJ, Escalante C. Cardiac emergencies in the cancer patient. In: Cancer and the Heart. Chapter 15, 2nd Edition. Ed(s) MS Ewer, E Yeh. PMPH-USA, 2012.
3. Yeung SJ, Gagel RF. Endocrine complications and paraneoplastic syndromes. In: Cancer Medicine. Chapter 156, 8th Edition. Ed(s) D Kufe, R Bast Jr, W Hait, W Hong, R Pollack, R Weichselbaum, J Holland, E Frei III. BC Decker Inc: Hamilton, Ontario, Canada, 2010.
4. Pan J, Yeung SC. Farnesyltransferase inhibitors of microbial origins in cancer therapy. In: Emerging cancer therapy: microbial approaches and biotechnological tools. Chapter 16. Ed(s) AM Fialho, AM Chakrabarty. John Wiley & Sons Inc: Hoboken, NJ, 2010.
5. Yeung SJ, Escalante C. Oncologic Emergencies. In: Cancer Medicine. Chapter 142, 8th Edition. Ed(s) D Kufe, R Bast Jr, W Hait, W Hong, R Pollack, R Weichselbaum, J Holland, E Frei III. BC Decker Inc: Hamilton, Ontario, Canada, 2010.
6. Lee MH, Yeung SJ, Yang HY. 14-3-3 family proteins and checkpoint response. In: Cancer Drug Discovery and Development: Checkpoint response in cancer therapy. Chapter 5. Ed(s) ZH Siddik, BA Teicher. Humana Press: Totowa, NJ, 2009.
7. Yeung SJ. Cancer screening in cancer survivors. In: Medical Care of Cancer Patients. Chapter 75. Ed(s) SJ Yeung, C Escalante, RF Gagel. BC Decker Inc: Hamilton, Ontario, Canada, 2009.
8. Row M, Yeung SJ. Emergency care: special considerations in cancer patients. In: Medical Care of Cancer Patients. Chapter 85. Ed(s) SJ Yeung, C Escalante, RF Gagel. BC Decker Inc: Hamilton, Ontario, Canada, 2009.
9. Yeung SJ, Gagel RF. Endocrine neoplastic syndromes. In: Medical Care of Cancer Patients. Chapter 23. Ed(s) SJ Yeung, C Escalante, RF Gagel. BC Decker Inc: Hamilton, Ontario, Canada, 2009.
10. Yeung SJ, Gagel RF. Pituitary and adrenal complications in cancer patients. In: Medical Care of Cancer Patients. Chapter 27. Ed(s) SJ Yeung, C Escalante, RF Gagel. BC Decker Inc: Hamilton, Ontario, Canada, 2009.
11. Lee MH, Yang H, Zhao R, Yeung SJ. Roles of negative and positive growth regulators in nasopharyngeal carcinoma. In: Apoptosis in Carcinogenesis and Chemotherapy. Chapter 12. Ed(s) GG Chen, PBS Lai. Springer Science + Business Media BV: Dordrecht, The Netherlands, 273-294, 2009.
12. Yeung SJ, Escalante C, Gagel RF. Survivorship - a reversal of fortune. In: Medical Care of Cancer Patients. Chapter 88. Ed(s) SJ Yeung, C Escalante, RF Gagel. BC Decker Inc: Hamilton, Ontario, Canada, 2009.

Books (edited and written)

1. Manzullo E, Yeung SC, Gonzalez CE, Escalante C. Ed(s) Manzullo E, Yeung SC, Gonzalez CE, Escalante C. Oncologic Emergency. In: MD Anderson Cancer Care Series. MD Anderson Cancer Center Press, 2015.
2. Yeung SJ, Escalante C, Gagel RF. Medical Care of Cancer Patients. B. C. Decker Inc. Ontario, Canada, 2009.
3. Yeung SJ, Escalante C. Oncologic Emergency. B. C. Decker Inc. Canada, Ontario, 2002.

Grant & Contract Support

Title: A randomized trial to compare fentanyl nasal spray with intravenous opioids to treat severe pain in cancer patients in the emergency department setting
Funding Source: DepoMed Pharmaceuticals
Role: Principal Investigator
Duration: 2015 - 2016
 
Title: A Randomized Controlled Double-blind Trial of the Added Value of Fentanyl Nasal Spray (Lazanda) to Hydromorphone Demand PCA for Treatment of Severe Cancer Pain in the Emergency Department
Funding Source: DepoMed Pharmaceuticals
Role: Co-Principal Investigator
Duration: 2/1/2014 - 11/1/2016
 
Title: Molecular and Cellular Signaling Transduction Pathways
Funding Source: Vietnam Education Foundation
Role: Co-Investigator
Duration: 7/1/2013 - 6/1/2015
 
Title: A double-blind placebo-based pilot trial of calcium alumina-silicate (CASAD) in the treatment in the treatment of severe diarrhea (grade 3 or 4) in cancer patients presenting for emergency care.
Funding Source: Salient Pharmaceuticals
Role: Principal Investigator
Duration: 2013 - 2014
 
Title: The Impact of Obesity and Diabetes on the Survival of Myeloma Patients
Funding Source: The University of Texas MD Anderson Cancer Center
Role: Principal Investigator-MDACC
Principal Investigator: Kwak
Duration: 11/1/2012 - 11/1/2013
 
Title: The evaluation of Pim kinase inhibitors in pancreatic cancer
Funding Source: AstraZeneca
Role: Principal Investigator
Duration: 2010 - 2011
 
Title: UPRCCC/MDACC Partnership for Excellence in Cancer Research, Pilot Case-Comparison Study of Metabolic Syndrome and Estrogen-Receptor-Positive Breast Cancer in Puerto Rico
Funding Source: NIH/NCI
Role: Co-Program Leader
Duration: 9/2008 - 8/2013
 
Title: The impact of obesity and obesity treatment on breast cancer
Funding Source: Susan G. Komen Breast Cancer Foundation
Role: Principal Investigator
Duration: 8/2008 - 7/2013
 
Title: The Impact of Diabetes Mellitus on the Survival of Breast Cancer
Funding Source: Department of Defense (DOD)
Role: Principal Investigator
Duration: 2007 - 2009
 
Title: The Impact of Diabetes Mellitus on the Survival of Breast Cancer
Funding Source: The University of Texas MD Anderson Cancer Center
Role: Principal Investigator
Duration: 2007 - 2008
 
Title: Diabetes Mellitus and Impaired Glucose Tolerance in Cancer Patients
Funding Source: The University of Texas MD Anderson Cancer Center
Role: Principal Investigator
Duration: 2006 - 2008

Last updated: 3/15/2016