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Sai-Ching J Yeung, BS, R Ph, MS, Ph D, MD, FACP

Present Title & Affiliation

Primary Appointment

Professor, Department of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Adjunct Professor, Department of Internal Medicine, The University of Texas Medical School, Houston, TX
Adjunct Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Adjunct Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, The University of Houston, College of Pharmacy, Houston
Adjunct Professor, Texas A&M Health Science Center, Houston, TX
Adjunct Professor, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX

Education & Training

Degree-Granting Education

1991 St. Louis University, School of Medicine, St. Louis, MO, MD, Medicine
1988 University of Houston, College of Natural Sciences and Mathematics, Houston, TX, PHD, Biology
1985 University of Houston, College of Natural Sciences and Mathematics, Houston, TX, MS, Biology
1983 University of Houston, College of Pharmacy, Houston, TX, BS, Magna Cum Laude, Pharmacy

Board Certifications

1/2008 American Board of Internal Medicine, Subspecialty Board in Endocrinology and Metabolism
9/2004 American Board of Internal Medicine

Experience/Service

Academic Appointments

Associate Professor, Department of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2010-8/2013
Associate Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2006-8/2013

Administrative Appointments/Responsibilities

Deputy Chief, Section of Emergency Care, Department of General Internal Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2002-8/2010

Institutional Committee Activities

Member, Faculty Senate, 9/2013-8/2016

Honors and Awards

2013 US Faculty Scholar 2013, Vietnam Education Foundation

Selected Publications

Peer-Reviewed Original Research Articles

1. Matthias N, Lockworth CR, Zhang F, Lee MH, Yeung SC, Tsai KY, Hamir AN. Multiple cystic sweat gland tumors in transgenic mice. Comp Med 62(1):27-30, 2/2012. PMCID: PMC3276389.
2. He XX, Tu SM, Lee MH, Yeung SC. Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients. Ann Oncol 22(12):2640-5, 12/2011. e-Pub 3/17/2011. PMCID: PMC3221513.
3. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med 15(4):825-36, 4/2011. e-Pub 5/2010. PMCID: PMC2930937.
4. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121(3):851-65, 3/2011. e-Pub 2/7/2011. PMCID: PMC3049400.
5. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res 71(3):884-94, 2/2011. e-Pub 12/2010. PMCID: PMC3358120.
6. Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Exenatide improves glucocorticoid-induced glucose intolerance in mice. Diabetes Metab Syndr Obes 4:61-5, 2011. e-Pub 1/26/2011. PMCID: PMC3064408.
7. Jin Q, Yuan LX, Boulbes DR, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res 12(6). e-Pub 11/16/2010. PMID: 21080941.
8. Hanzelka KM, Zalpour A, Afshar-Kharghan V, Fitousis K, Anderlini P, Yeung SC. Severe thrombosis and acute thrombocytopenia in a cancer patient. Am J Hematol 85(11):887-90, 11/2010. PMID: 20721891.
9. Su CH, Zhao R, Velazquez-Torres G, Chen J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3-3s in response to DNA damage. Mol Cancer 9:243, 9/2010. e-Pub 9/2010. PMCID: PMC2949799.
10. Chen B, Liu C-G, Jin F, Sun Y-N, Zhao T-T, Zhang L-N, Li S, Yeung SC. The role of fine-wire localization breast biopsy in the management of BI-RADS category 3-5 non-palpable breast lesions in northeastern Chinese women. Health 2(4):291-294, 4/2010.
11. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer 9:42, 2010. e-Pub 2/22/2010. PMCID: PMC2839967.
12. Cheng C, Wu G, Yeung SC, Li R, Bella AE, Pang J, Zhong FT, Luo H, Jin Y, Pan J. Serum protein profiles in myasthenia gravis. Ann Thorac Surg 88(4):1118-23, 10/2009. PMID: 19766792.
13. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic Therapies Affect Risk of Pancreatic Cancer. Gastroenterology 137(2):482-8, 8/2009. e-Pub 4/16/2009. PMCID: PMC2735093.
14. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation. Am J Pathol 175(1):400-11, 7/2009. e-Pub 6/2009. PMCID: PMC2708825.
15. Pan J, Song E, Cheng C, Lee MH, Yeung SC. Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms? Autophagy 5(1). e-Pub 1/4/2009. PMID: 19066466.
16. Yeung SC, Gully C, Lee MH. Aurora-B kinase inhibitors for cancer chemotherapy. Mini Rev Med Chem 8(14):1514-25, 12/2008. PMID: 19075809.
17. Pan J, Chen B, Su CH, Zhao R, Xu ZX, Sun L, Lee MH, Yeung SC. Autophagy induced by farnesyltransferase inhibitors in cancer cells. Cancer Biol Ther 7(10). e-Pub 10/21/2008. PMID: 18769123.
18. Cheng C, Yeung SC, Zhong FT, Xiong Y, Luo HH, Ji S, Pan J. Aneurysmal bone cyst in the first rib. Ann Thorac Surg 85(6):2118-20, 6/2008. PMID: 18498837.
19. Yao JC, Phan A, Hoff PM, Chen HX, Charnsangavej C, Yeung SC, Hess K, Ng C, Abbruzzese JL, Ajani JA. Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol 26(8):1316-23, 3/10/2008. PMID: 18323556.
20. Yeung SC, She M, Yang H, Pan J, Sun L, Chaplin D.. Combination Chemotherapy including Combretastatin A4 Phosphate and Paclitaxel is Effective against Anaplastic Thyroid Cancer in a Nude Mouse Xenograft Model. J Clin Endocrinol Metab 92(92:2902-2909):2902-9, 6/2007. e-Pub 6/2007. PMID: 17550961.
21. Yao JC, Zhang JX, Rashid A, Yeung SC, Szklaruk J, Hess K, Xie K, Ellis L, Abbruzzese JL, Ajani JA. Clinical and in vitro studies of imatinib in advanced carcinoid tumors. Clin Cancer Res 13(1):234-40, 1/2007. PMID: 17200360.
22. Huyghe E, Nohra J, Caron P, Bennet A, Khedis M, Otal P, Soulie M, Yeung SC, Plante P. Lethal posttraumatic rupture of a pheochromocytoma: lesson from a postmortem diagnosis. Urol Int 79(1):83-5, 2007. PMID: 17627175.
23. She M, Yang H, Sun L, Yeung SC. Redox control of manumycin A-induced apoptosis in anaplastic thyroid cancer cells: involvement of the xenobiotic apoptotic pathway. Cancer Biol Ther 5(3):275-80, 3/2006. e-Pub 3/6/2006. PMID: 16410725.
24. Mambo E, Chatterjee A, Xing M, Tallini G, Haugen BR, Yeung SC, Sukumar S, Sidransky D. Tumor-specific changes in mtDNA content in human cancer. Int J Cancer 116(6):920-4, 10/2005. PMID: 15856456.
25. Escalante CP, Weiser MA, Lam T, Ho V, Yeung SC. Hypertension in cancer patients seeking acute care: an opportunity to intervene. Am J Med Sci 330(3):120-7, 9/2005. PMID: 16174995.
26. Pan J, Huang H, Sun L, Fang B, Yeung SC. Bcl-2-associated X protein is the main mediator of manumycin a-induced apoptosis in anaplastic thyroid cancer cells. J Clin Endocrinol Metab 90(6):3583-91, 6/2005. e-Pub 3/15/2005. PMID: 15769983.
27. She M, Pan I, Sun L, Yeung SC. Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells. Leukemia 19(4):595-602, 4/2005. PMID: 15744347.
28. Dackiw A,Pan, J, Xu, G,Yeung,SC. Modulation of parathyroid hormone-related protein levels (PTHrP) in anaplastic thyroid cancer. Surgery 138(3):456-463, 2005. PMID: 16213899.
29. Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN. Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer. Clin Cancer Res 10(24):8594-602, 12/2004. PMID: 15623643.
30. Hu W, Wu W, Verschraegen CF, Chen L, Mao L, Yeung SC, Kudelka AP, Freedman RS, Kavanagh JJ. Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor. Proteomics 3(10):1904-11, 10/2003. PMID: 14625852.
31. Yang HL, Pan JX, Sun L, Yeung SC. p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in anaplastic thyroid cancer cells. J Clin Endocrinol Metab 88(2):763-72, 2/2003. PMID: 12574211.
32. Ghori FY, Gutterman-Litofsky DR, Jamal A, Yeung SC, Arem R, Sherman SI. Socioeconomic factors and the presentation, management, and outcome of patients with differentiated thyroid carcinoma. Thyroid 12(11):1009-16, 11/2002. PMID: 12490079.
33. Hu W, Wu W, Yeung SC, Freedman RS, Kavanagh JJ, Verschraegen CF. Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor. Anticancer Res 22(2A):665-72, Mar-Apr, 3/2002. PMID: 12014635.
34. Gonzales, J, Yeung, SJ, Smith, JA. A high performance liquid chromatography assay validation of manumycin A in mouse plasma. J Chromatography B 776:177-182, 2002.
35. Pan J, Xu G, Yeung SC. Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel. J Clin Endocrinol Metab 86(10):4731-40, 10/2001. PMID: 11600533.
36. Xu, GP, Pan, J, Martin, C, Yeung, SC. The role of angiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinoma. J. Clin. Endocrinol. Metab 86:1769-1777, 2001.
37. Yeung SC, Xu G, Pan J, Christgen M, Bamiagis A. Manumycin enhances the cytotoxic effect of paclitaxel on anaplastic thyroid carcinoma cells. Cancer Res 60(3):650-6, 2/2000. PMID: 10676649.
38. Liao W, Yeung SC, Chan L. Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum. J Biol Chem 273(42):27225-30, 10/1998. PMID: 9765244.
39. Yeung SC, Chiu AC, Vassilopoulou-Sellin R, Gagel RF. The endocrine effects of nonhormonal antineoplastic therapy. Endocr Rev 19(2):144-72, 4/1998. PMID: 9570035.
40. Yeung SC, Eton O, Burton DW, Deftos LJ, Vassilopoulou-Sellin R, Gagel RF. Hypercalcemia due to parathyroid hormone-related protein secretion by melanoma. Horm Res 49(6):288-91, 1998. PMID: 9623520.
41. Yeung SC, Anderson J, Kobayashi K, Oka K, Chan L. Production of rabbit polyclonal antibody against apobec-1 by genetic immunization. J Lipid Res 38(12):2627-32, 12/1997. PMID: 9458285.
42. Yeung SJ, Chen SH, Chan L. Ubiquitin-proteasome pathway mediated intracellular degradation of apolipoprotein B. Biochemistry 35(43):13843-8, 10/1996. PMID: 8901527.
43. Yeung, SJ, Go, R, Balasubramanyam, A . Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm. Thyroid 5(5):403-5, 1995. PMID: 8563481.
44. Raju, U, Nunez-Regueiro, M, Cook, R, Kaetzel, MA, Yeung, SJ, Eskin, A. Identification of an annexin-like protein and its possible role in the Aplysia eye circadian system. J Neurochem 61(4):1236-45, 1993. PMID: 8376982.
45. Bem WT, Yeung SJ, Belcheva M, Barg J, Coscia CJ. Age-dependent changes in the subcellular distribution of rat brain mu-opioid receptors and GTP binding regulatory proteins. J Neurochem 57(5):1470-7, 11/1991. PMID: 1655974.
46. Raju U, Yeung SJ, Eskin A. Involvement of proteins in light resetting ocular circadian oscillators of Aplysia. Am J Physiol 258(1 Pt 2):R256-62, 1990. PMID: 2154135.
47. Yeung SJ, Eskin A. Responses of the circadian system in the Aplysia eye to inhibitors of protein synthesis. J. Biol. Rhythms 3:225-36, 1988.
48. Yeung SJ, Eskin A. Involvement of a specific protein in the regulation of a circadian rhythm in Aplysia eye. Proc Natl Acad Sci U S A 84(1):279-83, 1987. PMID: 3025861.
49. Eskin A, Yeung SJ, Klass MR. Requirement for protein synthesis in the regulation of a circadian rhythm by serotonin. Proc Natl Acad Sci U S A 81(23):7637-41, 12/1984. PMID: 6095312.

Invited Articles

1. Yeung SCJ, Habra MA. PTHLH (parathyroid hormone-like hormone). Atlas Genet. Cytogenet. Oncol. Haematol.(12):234(9), 2008.
2. Chui AC, Yeung SJ. Clinical Update: Hypothyroidism. Cortlandt Forum 13(12):111-17, 2000.
3. Yeung, SJ, Chui, ACand Balasubramanyam, A. Diagnostic Challenge: A young woman with no thirst for life. Cortlandt Forum. 13(4):42-43, 2000.
4. Chui AC, Yeung SC. Diagnostic Challenge: An endocrinologic enigma. Cortlandt Forum 13(3):55-57, 2000.
5. Yeung SC, Chui AC. Difficult Diagnosis: A tale of two lesions – Cushing’s syndrome in a woman with lung and adrenal masses. Primary Care & Cancer 20:23-27, 2000.
6. Yeung SC, Amato R, Gagel RF. Difficult Diagnosis: What is causing this patient's muscle weakness? Primary Care & Cancer 19:5-9, 1999.

Abstracts

1. Elsayem A, Merriman K, GonzalezC, Yeung SC, Chaftari P, Henderson J, Todd KH. Intensive Care Unit Admissions and Mortality in Patients admitted through the Emergency Department of a Comprehensive Cancer Center. Proceedings of ASCO 2014, 2014.

Book Chapters

1. Lee MH, Yeung SJ, Yang HY. 14-3-3 family proteins and checkpoint response. In: Cancer Drug Discovery and Development: Checkpoint response in cancer therapy. Chapter 5. Ed(s) ZH Siddik, BA Teicher. Humana Press: Totowa, NJ, 2009.
2. Lee MH, Yang H, Zhao R, Yeung SJ. Roles of negative and positive growth regulators in nasopharyngeal carcinoma. In: Apoptosis in Carcinogenesis and Chemotherapy. Chapter 12. Ed(s) GG Chen, PBS Lai. Springer Science+Business Media BV: Dordrecht, The Netherlands, 273-294, 2009.
3. Yeung SJ, Escalante C. Cardiac emergencies in the cancer patient. In: Cancer and the Heart. Chapter 17. Ed(s) MS Ewer, E Yeh. PMPH-USA, 2006.
4. Habra MA, Busaidy NL, Yeung SJ, Vassilopoulou-Sellin R. Endocrine manifestations of non-endocrine tumors. In: The MD Anderson Manual of Medical Oncology. Chapter 38. Ed(s) HN Katarjian, C Koller, R Wolff. McGraw-Hill Professional: New York, NY, 2006.
5. Yeung SJ, Gagel RF. Endocrine complications and paraneoplastic syndromes. In: Cancer Medicine. Chapter 156, 7th Edition. Ed(s) D Kufe, R Bast Jr, W Hait, W Hong, R Pollack, R Weichselbaum, J Holland, E Frei III. BC Decker Inc: Hamilton, Ontario, Canada, 2005.
6. Yeung SJ, Escalante C. Oncologic Emergencies. In: Cancer Medicine. Chapter 142, 7th Edition. Ed(s) D Kufe, R Bast Jr, W Hait, W Hong, R Pollack, R Weichselbaum, J Holland, E Frei III. BC Decker Inc: Hamilton, Ontario, Canada, 2005.
7. Yeung SJ. Preclinical Studies of Chemotherapy for Undifferentiated Thyroid Carcinom, Chapter 7. In: Advances in Molecular and Cellular Endocrinology. Volume 4. Ed(s) BR Haugen. Elsevier Science: Amsterdam, Holland, 117-144, 2005.
8. Yeung SJ, Gagel RF. Endocrine complications and paraneoplastic syndromes. In: Cancer Medicine. Chapter 156, 6th Edition. Ed(s) JF Holland, E Frei III, RC Bast Jr, DW Kufe, RE Pollock, RR Weichselbaum. BC Decker Inc: Hamilton, Ontario, Canada, 2003.
9. Yeung SJ, Escalante C. Oncologic Emergencies. In: Cancer Medicine. Chapter 159, 6th Edition. Ed(s) JF Holland, E Frei III, RC Bast Jr, DW Kufe, RE Pollock, RR Weichselbaum. BC Decker Inc: Hamilton, Ontario, Canada, 2003.
10. Yeung SJ, Lazo G, Gagel RF. Endocrine and Metabolic Emergencies. In: Oncologic Emergency. Chapter 8. Ed(s) SJ Yeung, C Escalante. BC Decker Inc: Hamilton, Ontario, Canada, 2002.
11. Levett M, Row M, Yeung SJ. Miscellaneous Oncologic Emergencies. In: Oncologic Emergency. Chapter 23. Ed(s) SJ Yeung, C Escalante. BC Decker Inc: Hamilton, Ontario, Canada, 2002.
12. Yeung SJ. Orthopedic Oncologic Emergencies. In: Oncologic Emergency. Chapter 18. Ed(s) SJ Yeung, C Escalante. BC Decker Inc: Hamilton, Ontario, Canada, 2002.
13. Yeung SJ, Gagel RF. Endocrine complications. In: Cancer Medicine. Chapter 155, 5th Edition. Ed(s) JF Holland, E Frei III, RC Bast Jr, DW Kufe, RE Pollock, RR Weichselbaum. BC Decker Inc: Hamilton, Ontario, Canada, 2389-2398, 2000.
14. Yeung SJ, Hubbard JR. Endocrine and metabolic diseases. In: Primary Medicine for Psychiatrists: Practitioner’s Guide. Ed(s) JR Hubbard, DD Short. Plenum Publishing Corp: New York, NY, 1-27, 1997.

Books (edited and written)

1. Yeung SJ, Escalante C, Gagel RF. Medical Care of Cancer Patients. B. C. Decker Inc. Ontario, Canada, 2009.
2. Yeung SJ, Escalante C. Oncologic Emergency. B. C. Decker Inc. Canada, Ontario, 2002.

Manuals, Teaching Aids, Other Teaching Publications

1. Busaidy, NL, Busaidy, KF, Yeung, SC. A 45-year-old man with a maxillary mass and hypercalcemia. 7, 1, http://www.medscape.com/diabetes-endocrinologyhome, http://www.medscape.com/viewarticle/468503 , 2005.
2. Jimenez, C, Yeung, SC. What is causing this patient bone pain and muscular weakness? A case report of Fanconi syndrome complicated with osteomalacia due to a lymphoma. http://www.medscape.com/diabetes-endocrinologyhome, 2003.

Grant & Contract Support

Title: A double-blind placebo-based pilot trial of calcuim alumnia-silicate (CASAD) in the treatment in the treatment of severe diarrhea (grade 3 or 4) in cancer patients presenting for emergency care.
Funding Source: Salient Pharmaceuticals
Role: Principal Investigator
Duration: 2013 - 2014
 
Title: The impact of obesity and obesity treatment on breast cancer
Funding Source: Susan G. Komen Breast Cancer Foundation
Role: Principal Investigator
Duration: 8/2008 - 7/2013
 
Title: The Impact of Diabetes Mellitus on the Survival of Breast Cancer
Funding Source: Department of Defense (DOD)
Role: Principal Investigator
Duration: 2007 - 2009
 
Title: The Impact of Diabetes Mellitus on the Survival of Breast Cancer
Funding Source: The University of Texas MD Anderson Cancer Center
Role: Principal Investigator
Duration: 2007 - 2008
 
Title: Diabetes Mellitus and Impaired Glucose Tolerance in Cancer Patients
Funding Source: The University of Texas MD Anderson Cancer Center
Role: Principal Investigator
Duration: 2006 - 2008

Last updated: 7/9/2014