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Sam M. Hanash, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Director, Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Center for Global Cancer Early Detection, The University of Texas MD Anderson Cancer Center, Houston, TX
Distinguished Chair, Evelyn & Sol Rubenstein Distinguished Chair for Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Clinical Cancer Prevention - Research, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
6767 Bertner Street
Unit Number: 1013
Houston, TX 77030
Room Number: S13.8336C
Phone: 713-745-5242
Fax: 713-792-1474
Email: shanash@mdanderson.org

Education & Training

Degree-Granting Education

1976 University of Michigan, Ann Arbor, MI, PHD, Human Genetics
1972 American University of Beirut, Lebanon, Beirut, BS, Human Genetics
1972 American University of Beirut, Lebanon, Beirut, MD, Human Genetics

Honors and Awards

2013-present Evelyn & Sol Rubenstein Distinguished Chair for Cancer Prevention, University of Texas MD Anderson Cancer Center

Selected Publications

Peer-Reviewed Original Research Articles

1. Taguchi A, Taylor AD, Rodriguez J, Celiktas M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM. A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets. Cancer Res. e-Pub 6/2014. PMID: 24970476.
2. Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash SM, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 5:3361, 2/2014. PMCID: PMC4017859.
3. Mao J, Ladd J, Gad E, Rastetter L, Johnson MM, Marzbani E, Childs JS, Lu H, Dang Y, Broussard E, Stanton SE, Hanash SM, Disis ML. Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. J Transl Med 12(1):121, 2014. e-Pub 5/2014. PMCID: PMC4022541.
4. Hanash SM, Schliekelman M. Proteomic profiling of the tumor microenvironment: recent insights and the search for biomarkers. Genome Med 6(2):12, 2014. e-Pub 2/2014. PMCID: PMC3978437.
5. Tam KW, Zhang W, Soh J, Stastny V, Chen M, Sun H, Thu K, Rios JJ, Yang C, Marconett CN, Selamat SA, Laird-Offringa IA, Taguchi A,Hanash SM, Shames D, Ma X, Zhang MQ, Lam WL, Gazdar A. CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non-Small-Cell Lung Cancer. J Thorac Oncol 8(11):1378-88, 11/2013. PMCID: PMC3951422.
6. Sin DD, Tammemagi CM, Lam S, Barnett MJ, Duan X, Tam A, Auman H, Feng Z, Goodman GE,Hanash SM, Taguchi A. Pro-Surfactant Protein B as a Biomarker for Lung Cancer Prediction. J Clin Oncol. e-Pub 11/2013. PMCID: PMC3871515.
7. Taguchi A, Hanash SM, Rundle AG, McKeague IW, Tang DL, Darakjy S, Gaziano JM, Sesso HD, Perera F. Circulating pro-surfactant protein B as a risk biomarker for lung cancer. Cancer Epidemiol Biomarkers Prev. e-Pub 7/2013. PMCID: PMC3866965.
8. Wu SL, Taylor AD, Lu Q, Hanash SM , Im H, Snyder M, Hancock WS. Identification of potential glycan cancer markers with sialic acid attached to sialic acid and up-regulated fucosylated galactose structures in epidermal growth factor receptor secreted from A431 cell line. Mol Cell Proteomics 12(5):1239-49, 5/2013. e-Pub 1/2013. PMCID: PMC3650335.
9. LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM , VanBrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A 110(1):93-8, 1/2013. e-Pub 12/2012. PMCID: PMC3538269.
10. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. PLoS One 8(6):e67054, 2013. e-Pub 6/2013. PMCID: PMC3677922.
11. Zhang S, Mercado-Uribe I, Hanash SM, Liu J. iTRAQ-Based Proteomic Analysis of Polyploid Giant Cancer Cells and Budding Progeny Cells Reveals Several Distinct Pathways for Ovarian Cancer Development. PLoS One 8(11):e80120, 2013. e-Pub 11/2013. PMCID: PMC3858113.
12. Thome CH, Dos Santos GA, Ferreira GA, Scheucher PS, Izumi C, Leopoldino AM, Simão AM, Ciancaglini P, de Oliveira KT, Chin A, Hanash SM, Falcão RP, Rego EM, Greene LJ, Faça VM. Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity. Mol Cell Proteomics 11(12):1898-912, 12/2012. e-Pub 9/2012. PMCID: PMC3518132.
13. Li CI, Mirus JE, Zhang Y, Ramirez AB, Ladd JJ, Prentice RL, McIntosh MW, Hanash SM, Lampe PD. Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study. Breast Cancer Res Treat 135(2):611-8, 9/2012. e-Pub 8/2012. PMCID: PMC3439142.
14. Lu H, Ladd J, Feng Z, Wu M, Goodell V, Pitteri SJ, Li CI, Prentice R, Hanash SM, Disis ML. Evaluation of known oncoantibodies, HER2, p53, and cyclin B1, in prediagnostic breast cancer sera. Cancer Prev Res (Phila) 5(8):1036-43, 8/2012. e-Pub 6/2012. PMCID: PMC3790582.
15. Ladd JJ, Busald T, Johnson MM, Zhang Q, Pitteri SJ, Wang H, Brenner DE, Lampe PD, Kucherlapati R, Feng Z, Prentice RL, Hanash SM. Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. Cancer Prev Res (Phila) 5(4):655-64, 4/2012. e-Pub 1/2012. PMCID: PMC3419141.
16. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 20(3):289-99, 9/2011. PMCID: PMC3406925.
17. Hanash SM. Progress in mining the human proteome for disease applications. OMICS 15(3):133-9, 3/2011. PMCID: PMC3118795.
18. Hanash SM. Why have protein biomarkers not reached the clinic? Genome Med 3(10):66, 2011. e-Pub 10/2011. PMCID: PMC3239228.
19. Pitteri S, Hanash SM. A systems approach to the proteomic identification of novel cancer biomarkers. Dis Markers 28(4):233-9, 2010. PMCID: PMC3833612.
20. Taylor AD, Hancock WS, Hincapie M, Taniguchi N, Hanash SM. Towards an integrated proteomic and glycomic approach to finding cancer biomarkers. Genome Med 1(6):57, 2009. e-Pub 6/2009. PMCID: PMC2703866.

Grant & Contract Support

Title: Biomarkers Bridging Pediatric and Adult Therapeutics
Funding Source: NIH/HD
Role: Collaborator
Duration: 12/1/2014 - 11/30/2016
 
Title: NCI Community Oncology Research Program (NCORP) Research Bases
Funding Source: NIH/NCI
Role: Co-Program Leader
Duration: 9/1/2014 - 8/31/2019
 
Title: Translating Novel Drug-Targetable Biomarkers to Treat Graft Versus Host Disease
Funding Source: NIH/HD
Role: Co-Principal Investigator
Duration: 4/1/2014 - 3/31/2018
 
Title: Blood Based Biomarkers for Lung Cancer Early Detection and Evaluation of CT Based Lesions
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 9/25/2013 - 9/24/2014
 
Title: Blood Based Biomarkers of High Risk and Early Breast Cancer
Funding Source: Susan G. Komen Breast Cancer Foundation
Role: Principal Investigator
Duration: 2/27/2012 - 2/26/2015
 
Title: Early Diagnosis of Pancreatic Cancer
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 9/10/2010 - 6/30/2015
 
Title: Affinity Based Strategies to Fast Track Development of Colon Cancer Biomarkers
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 8/16/2010 - 6/30/2015
 
Title: Immune Diagnostics and Vaccine Targets: Breast Cancer Antigens from Mice to Women
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 9/1/2009 - 10/31/2014

Last updated: 9/17/2014