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Sam M. Hanash, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Clinical Cancer Prevention - Research, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Early Detection Platform, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
6767 Bertner Street
Unit Number: 1013
Houston, TX 77030
Room Number: S13.8336C
Phone: 713-745-5242
Fax: 713-792-1474
Email: shanash@mdanderson.org

Education & Training

Degree-Granting Education

1976 University of Michigan, Ann Arbor, MI, PHD, Human Genetics
1972 American University of Beirut, Lebanon, Beirut, BS, Human Genetics
1972 American University of Beirut, Lebanon, Beirut, MD, Human Genetics

Honors and Awards

2013-present Evelyn & Sol Rubenstein Distinguished Chair for Cancer Prevention, University of Texas MD Anderson Cancer Center

Selected Publications

Peer-Reviewed Original Research Articles
1. Ladd JJ, Chao T, Johnson MM, Qiu J, Chin A, Israel R, Pitteri SJ, Mao J, Wu M, Amon LM, McIntosh M, Li C, Prentice R, Disis N, Hanash SM. Autoantibody signatures involving glycolysis and splicesome proteins precede a diagnosis of breast cancer among post-menopausal women. Cancer Res 73(5):1502-13, 3/2013. e-Pub 12/2012. PMID: 23269276.
2. Chao T, Ladd JJ, Qiu J, Johnson MM, Israel R, Chin A, Wang H, Prentice RL, Feng Z, Disis ML, Hanash SM. Proteomic profiling of the autoimmune response to breast cancer antigens uncovers a suppressive effect of hormone therapy. Proteomics Clin Appl. e-Pub 2/2013. PMID: 23401414.
3. Liu S, Im H, Bairoch A, Cristofanilli M, Chen R, Deutsch EW, Dalton S, Fenyo D, Fanayan S, Gates C, Gaudet P, Hincapie M, Hanash SM, Kim H, Jeong SK, Lundberg E, Mias G, Menon R, Mu Z, Nice E, Paik YK, Uhlen M, Wells L, Wu SL, Yan F, Zhang F, Zhang Y, Snyder M, Omenn GS, Beavis RC, Hancock WS. A Chromosome-centric Human Proteome Project (C-HPP) to Characterize the Sets of Proteins Encoded in Chromosome 17. J Proteome Res 12(1):45-57, 1/2013. e-Pub 12/2012. PMID: 23259914.
4. Wu SL, Taylor AD, Lu Q, Hanash SM, Im H, Snyder M, Hancock WS. Identification of potential glycan cancer markers with sialic acid attached to sialic acid and up-regulated fucosylated galactose structures in epidermal growth factor receptor secreted from A431 cell line. Mol Cell Proteomics. e-Pub 1/2013. PMID: 23371026.
5. Lebeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, Vanbrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A 110(1):93-8, 1/2013. e-Pub 12/2012. PMID: 23248318.
6. Taguchi A, Hanash SM. Unleashing the Power of Proteomics to Develop Blood-Based Cancer Markers. Clin Chem 59(1):119-26, 1/2013. e-Pub 10/2012. PMID: 23099557.
7. Thome CH, Dos Santos GA, Ferreira GA, Scheucher PS, Izumi C, Leopoldino AM, Simão AM, Ciancaglini P, de Oliveira KT, Chin A, Hanash SM, Falcão RP, Rego EM, Greene LJ, Faça VM. Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity. Mol Cell Proteomics 11(12):1898-912, 12/2012. e-Pub 9/2012. PMCID: PMC3518132.
8. Hanash SM. A call for a fresh new look at the plasma proteome. Proteomics Clin Appl 6(9-10):443-6, 10/2012. PMID: 22930569.
9. Li CI, Mirus JE, Zhang Y, Ramirez AB, Ladd JJ, Prentice RL, McIntosh MW, Hanash SM, Lampe PD. Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study. Breast Cancer Res Treat 135(2):611-8, 9/2012. e-Pub 8/2012. PMCID: PMC3439142.
10. Lu H, Ladd J, Feng Z, Wu M, Goodell V, Pitteri SJ, Li CI, Prentice R, Hanash SM, Disis ML. Evaluation of known oncoantibodies, HER2, p53, and cyclin B1, in prediagnostic breast cancer sera. Cancer Prev Res (Phila) 5(8):1036-43, 8/2012. e-Pub 6/2012. PMID: 22715141.
11. Hanash SM, Schliekelman M, Zhang Q, Taguchi A. Integration of proteomics into systems biology of cancer. Wiley Interdiscip Rev Syst Biol Med 4(4):327-37, Jul-Aug, 7/2012. e-Pub 3/2012. PMID: 22407608.
12. Press JZ, Reyes M, Pitteri SJ, Pennil C, Garcia R, Goff BA, Hanash SM, Swisher EM. Microparticles from ovarian carcinomas are shed into ascites and promote cell migration. Int J Gynecol Cancer 22(4):546-52, 5/2012. PMID: 22315094.
13. Kani K, Faca VM, Hughes LD, Zhang W, Fang Q, Shahbaba B, Luethy R, Erde J, Schmidt J, Pitteri SJ, Zhang Q, Katz JE, Gross ME, Plevritis SK, McIntosh MW, Jain A, Hanash SM, Agus DB, Mallick P. Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. Mol Cancer Ther 11(5):1071-81, 5/2012. e-Pub 3/2012. PMID: 22411897.
14. Amon LM, Pitteri SJ, Li CI, McIntosh M, Ladd JJ, Disis M, Porter P, Wong CH, Zhang Q, Lampe P, Prentice RL, Hanash SM. Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancer. Cancer Res 72(8):1935-42, 4/2012. e-Pub 2/2012. PMID: 22367215.
15. Ladd JJ, Busald T, Johnson MM, Zhang Q, Pitteri SJ, Wang H, Brenner DE, Lampe PD, Kucherlapati R, Feng Z, Prentice RL, Hanash SM. Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. Cancer Prev Res (Phila) 5(4):655-64, 4/2012. e-Pub 1/2012. PMCID: PMC3419141.
16. Paik YK, Omenn GS, Uhlen M, Hanash SM, Marko-Varga G, Aebersold R, Bairoch A, Yamamoto T, Legrain P, Lee HJ, Na K, Jeong SK, He F, Binz PA, Nishimura T, Keown P, Baker MS, Yoo JS, Garin J, Archakov A, Bergeron J, Salekdeh GH, Hancock WS. Standard guidelines for the chromosome-centric human proteome project. J Proteome Res 11(4):2005-13, 4/2012. e-Pub 3/2012. PMID: 22443261.

Book Chapters
1. Hanash SM and Taguchi A. Cancer Proteomics. In: Molecular Oncology. Ed(s) C. Sawyers. In Press.

Grant & Contract Support

Title: Biomarkers: Bridging Pediatric and Adult Therapeutics
Funding Source: NIH/HD
Role: Co-Principal Investigator
Duration: 12/1/2014 - 11/30/2016
 
Title: Intergrative Molecular Lung Disease Networks and its Applications
Funding Source: NIH/HD
Role: Co-Principal Investigator
Duration: 4/1/2014 - 11/30/2016
 
Title: Blood Based Biomarkers of High Risk and Early Breast Cancer
Funding Source: Susan G. Komen Breast Cancer Foundation
Role: Principal Investigator
Duration: 2/27/2012 - 2/26/2015
 
Title: MMHCC In-depth Quantative Mass Spectrometry Based Proteome Profiling in Parallel with Genome Sequencing
Funding Source: SAIC-Fredrick Inc.
Role: Co-Principal Investigator
Duration: 2/20/2012 - 7/19/2014
 
Title: Confirmation Studies of Blood Based Biomarkers of Risk for Breast Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2011 - 6/30/2013
 
Title: Blood Based Biomarkers for Lung Cancer Early Detection and Evaluation of CT Based Lesions
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 9/25/2010 - 9/24/2013
 
Title: Early Diagnosis of Pancreatic Cancer
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 9/10/2010 - 6/30/2015
 
Title: Affinity Based Strategies to Fast Track Development of Colon Cancer Biomarkers
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 8/16/2010 - 6/30/2015
 
Title: Preventive Interventions Leadership U01
Funding Source: NIH/NCI
Role: Principal Investigator-MDACC
Duration: 9/24/2009 - 8/31/2014
 
Title: Immunodiagnostics and Immunologic Targeting of Breast Cancer Antigens from Transgenic Mouse Models to Breast Cancer Patients
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 9/1/2009 - 8/31/2014

Last updated: 5/21/2013