Sang Hyun Cho, Ph.D.

Peer-Reviewed Articles

1. Moktan H, Jayarathna S, Cho SH. Sensitivity enhancement of an experimental benchtop x-ray fluorescence imaging system by deploying a single crystal cadmium telluride detector system optimized for high flux x-ray operations. Nucl Instrum Methods Phys Res A 1025:166198, 2022. e-Pub 2021. PMID: 35340930.
2. Moktan H, Panta RK, Cho SH. Bias-voltage dependent operational characteristics of a fully spectroscopic pixelated cadmium telluride detector system within an experimental benchtop x-ray fluorescence imaging setup. Biomed Phys Eng Express 8(1), 2021. e-Pub 2021. PMID: 34874017.
3. Jayarathna S, Ahmed MF, O'Ryan L, Moktan H, Cui Y, Cho SH. Characterization of a Pixelated Cadmium Telluride Detector System Using a Polychromatic X-Ray Source and Gold Nanoparticle-Loaded Phantoms for Benchtop X-Ray Fluorescence Imaging. IEEE Access 9:49912-49919, 2021. e-Pub 2021. PMID: 33996343.
4. Kim JB, Mackeyev Y, Raghuram S, Cho SH, Krishnan S. Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization. Int J Radiat Biol 97(8):1129-1139, 2021. e-Pub 2021. PMID: 33428854.
5. Tseng H W, Vedantham S, Cho SH, Karellas A. Joint optimization of collimator and reconstruction parameters in x-ray fluorescence computed tomography using analytical point spread function and model observer. IEEE Trans Biomed Eng, 2019. PMID: 31899411.
6. Manohar N, Reynoso F, Jayarathna S, Moktan H, Ahmed MF, Diagaradjane P, Krishnan S, Cho SH. High-sensitivity imaging and qualification of intratumoral distributions of gold nanoparticles using a benchtop x-ray fluorescence imaging system. Optics Letters 44(21):5314-5317, 2019. PMID: 31674996.
7. Deng L, Yasar S, Ahmed MF, Jayarathna S, Feng P, Wei B, Vedantham S, Karellas A, Cho SH. Investigation of transmission computed tomography (CT) image quality and x-ray dose achievable from an experimental dual-mode benchtop x-ray fluorescence CT and transmission CT system. J Xray Sci Technol 27(3):431-442, 2019. PMID: 30909268.
8. Deng L, Ahmed MF, Jayarathna S, Feng P, Wei B, Cho SH. A detector's eye view (DEV)-based OSEM algorithm for benchtop x-ray fluorescence computed tomography (XFCT) image reconstruction. Phys Med Biol 64(8):08NT02, 2019. e-Pub 2019. PMID: 30958796.
9. Jayarathna S, Manohar N, Ahmed MF, Krishnan S, Cho SH. Evaluation of dose point kernel rescaling methods for nanoscale dose estimation around gold nanoparticles using Geant4 Monte Carlo simulations. Sci Rep 9(1):3583, 2019. e-Pub 2019. PMID: 30837578.
10. Ahmed MF, Jayarathna S, Cho SH. Feasibility of x-ray fluorescence computed tomography (XFCT) imaging of human lung tumors loaded with gold nanoparticles: A Monte Carlo study. 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED):250-254, 2019.
11. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A new Standard DNA Damage (SDD) data format. Radiat Res 191(1):76-92, 2019. e-Pub 2018. PMID: 30407901.
12. Ahmed MF, Yasar S, Cho SH. Development of an attenuation correction method for direct x-ray fluorescence (XRF) imaging utilizing gold L-shell XRF photons. Med Phys 45(12):5543-5544, 2018. e-Pub 2018. PMID: 30307623.
13. Ahmed, MF, Yasar S, Cho SH. A Monte Carlo Model of a Benchtop X-Ray Fluorescence Computed Tomography System and Its Application to Validate a Deconvolution-based X-Ray Fluorescence Signal Extraction Method. IEEE Trans on Medical Imaging 37(11):2483-2492, 2018. e-Pub 2018. PMID: 29994762.
14. Manohar N, Reynoso FJ, Cho SH. Technical Note: A benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system with a high-power x-ray source and transmission CT imaging capability. Med Phys 45(10):4652-4659, 2018. e-Pub 2018. PMID: 30125950.
15. Khoo AM, Cho SH, Reynoso FJ, Aliru M, Aziz K, Bodd M, Yang X, Ahmed MF, Yasar S, Manohar N, Cho J, Tailor R, Thames HD, Krishnan S. Radiosensitization of Prostate Cancers In Vitro and In Vivo to Erbium-filtered Orthovoltage X-rays Using Actively Targeted Gold Nanoparticles. Sci Rep 7(1):18044, 2017. PMID: 29273727.
16. Reynoso FJ, Munro III JJ, Cho SH. Technical Note: Monte Carlo calculations of the AAPM TG-43 brachytherapy dosimetry parameters for a new titanium-encapsulated Yb-169 source. J Appl Clin Med Phys 18(4):193-199, 2017. e-Pub 2017. PMID: 28585277.
17. Cho J, Wang M, Gonzalez-Lepera C, Mawlawi O, Cho SH. Development of bimetallic (Zn@Au) nanoparticles as potential PET-imageable radiosensitizers. Med Phys 43(8):4775, 2016. PMID: 27487895.
18. Reynoso FJ, Tailor R, Wang C-K C, Cho SH. Comparison of filtered x-ray spectra and depth doses derived from a hybrid Monte Carlo model of an othovoltage x-ray unit with experimental measurements. Biomed Phys Eng Express 2(4):045011, 2016.
19. Cho J, Gonzalez-Lepera C, Manohar N, Kerr M, Krishnan S, Cho SH. Quantitative investigation of physical factors contributing to gold nanoparticle-mediated proton dose enhancement. Phys Med Biol 61(6):2562-2581, 2016. e-Pub 2016. PMID: 26952844.
20. Cho J, Campbell P, Wang M, Alqathami M, Mawlawi O, Kerr M, Cho SH. Feasibility of hydrogel fiducial markers for in vivo proton range verification using PET. Phys Med Biol 61(5):2162-2176. e-Pub 2016. PMID: 26907591.
21. Manohar N, Reynoso FJ, Diagaradjane P, Krishnan S, Cho SH. Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography. Sci Rep 6:22079, 2016. e-Pub 2016. PMID: 26912068.
22. Schuemann J, Berbeco R, Chithrani DB, Cho SH, Kumar R, McMahon SJ, Sridhar S, Krishnan S. Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization. Int J Radiat Oncol Biol Phys 94(1):189-205, 2016. e-Pub 2015. PMID: 26700713.
23. Manohar N, Jones BL, Cho SH. Improving x-ray fluorescence signal for benchtop polychromatic cone-beam x-ray fluorescence computed tomography by incident x-ray spectrum optimization: a Monte Carlo study. Med Phys 41(10):101906, 2014. PMID: 25281958.
24. Reynoso FJ, Manohar N, Krishnan S, Cho SH. Design of an Yb-169 source optimized for gold nanoparticle-aided radiation therapy. Med Phys 41(10):101709, 2014. PMID: 25281948.
25. Du W, Cho SH, Zhang X, Hoffman KE, Kudchadker RJ. Quantification of beam complexity in intensity-modulated radiation therapy treatment plans. Med Phys 41(2):021716, 2014. PMID: 24506607.
26. Manohar N, Reynoso FJ, Cho SH. Experimental demonstration of direct L-shell x-ray fluorescence imaging of gold nanoparticles using a benchtop x-ray source. Med Phys 40(8):080702, 2013. PMID: 23927295.
27. Reynoso FJ, Lee CD, Cheong SK, Cho SH. Implementation of a multisource model for gold nanoparticle-mediated plasmonic heating with near-infrared laser by the finite element method. Med Phys 40(7):073301, 2013. PMID: 23822455.
28. Siddiqi AK, Cho SH. Agar-based heat sensitive gel with linear thermal response over 65-80 degrees C. J Therm Anal Calorim 111(3):1805-1809, 2013.
29. Jones BL, Manohar N, Reynoso F, Karellas A, Cho SH. Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams. Phys Med Biol 57(23):N457-N67, 2012. e-Pub 2012. PMID: 23135315.
30. Yang Y, Liu J, Yang Y, Cho SH, Hu TC. Assessment of cell infiltration in myocardial infarction: a dose-dependent study using micrometer-sized iron oxide particles. Magn Reson Med 66(5):1353-1361, 2011. e-Pub 2011. PMID: 21710611.
31. Jones BL, Cho SH. The feasibility of polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects: a Monte Carlo study. Phys Med Biol 56(12):3719-3730, 2011. e-Pub 2011. PMID: 21628767.
32. Jones BL, Krishnan S, Cho SH. Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations. Med Phys 37(7):3809-3816, 2010. PMID: 20831089.
33. Cheong SK, Jones BL, Siddiqi AK, Liu F, Manohar N, Cho SH. X-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects using 110 kVp x-rays. Phys Med Biol 55(3):647-662, 2010. e-Pub 2010. PMID: 20071757.
34. Krishnan S, Diagaradjane P, Cho SH. Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy. Int J Hyperthermia 26(8):775-789, 2010. e-Pub 2010. PMID: 20858069.
35. Cheong SK, Krishnan S, Cho SH. Modeling of plasmonic heating from individual gold nanoshells for near-infrared laser-induced thermal therapy. Med Phys 36(10):4664-4671, 2009. PMID: 19928098.
36. Cho SH, Jones BL, Krishnan S. The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources. Phys Med Biol 54(16):4889-4905, 2009. e-Pub 2009. PMID: 19636084.
37. Han Y, Shin EH, Lim C, Kang SK, Park SH, Lah JE, Suh TS, Yoon M, Lee SB, Cho SH, Ibbott GS, Ju SG, Ahn YC. Dosimetry in an IMRT phantom designed for a remote monitoring program. Med Phys 35(6):2519-2527, 2008. PMID: 18649485.
38. Diagaradjane P, Shetty A, Wang JC, Elliott AM, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford RJ, Cho SH, Tunnell JW, Hazle JD, Krishnan S. Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Lett 8(5):1492-1500, 2008. e-Pub 2008. PMID: 18412402.
39. Zaman RT, Diagaradjane P, Wang J, Schwartz J, Rajaram N, Gill-Sharp KL, Cho SH, Rylander III HG, Payne D, Krishnan S, Tunnell JW. In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy. IEEE J of Selective Topics in Quantum Electronics 14(6):1715-1720, 2007.
40. Cheng CW, Cho SH, Taylor M, Das IJ. Determination of zero-field size percent depth doses and tissue maximum ratios for stereotactic radiosurgery and IMRT dosimetry: comparison between experimental measurements and Monte Carlo simulation. Med Phys 34(8):3149-3157, 2007. PMID: 17879776.
41. Cho SH, Vassiliev ON, Horton JL. Comparison between an event-by-event Monte Carlo code, NOREC, and ETRAN for electron scaled point kernels between 20 keV and 1 MeV. Radiat Environ Biophys 46(1):77-83, 2007. e-Pub 2007. PMID: 17219152.
42. Kim CH, Cho, SH, Xu, XG. PRDC-A software package for personnel radiation dose calculation, submitted July 2005. Radiation Protection Dosimetry 118(3):243-250, 2006.
43. Gifford KA, Mourtada F, Cho SH, Lawyer A, Horton JL. Monte Carlo calculations of the dose distribution around a commercial gynecologic tandem applicator. Radiother Oncol 77(2):210-215, 2005. e-Pub 2005. PMID: 16216363.
44. Cho SH. Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol 50(15):N163-73, 2005. e-Pub 2005. PMID: 16030374.
45. Cho SH, Vassiliev ON, Lee S, Liu HH, Ibbott GS, Mohan R. Reference photon dosimetry data and reference phase space data for the 6 MV photon beam from varian clinac 2100 series linear accelerators. Med Phys 32(1):137-148, 2005. PMID: 15719964.
46. Sahoo N, Kazi AM, Cho SH, Sadagopan R, Shui AS. Effect of detector properties on beam profile measurement of small field MV x-ray beams. Biomedizinische Technik/Biomedical Engineering 50(Supplement 1):741-742, 2005.
47. Bencomo JA, Chu C, Tello VM, Cho SH, Ibbott GS. Anthropomorphic breast phantoms for quality assurance and dose verification. J Appl Clin Med Phys 5(1):36-49, 2004. e-Pub 2004. PMID: 15753932.
48. Cho, SH, Reece, WD, Kim, C-H. Validity of two simple rescaling methods for electron/beta dose point kernels in heterogeneous source-target geometry. Radiation Physics and Chemistry 69(4):265-272, 2004.
49. Cho SH, Ibbott GS. Reference photon dosimetry data: a preliminary study of in-air off-axis factor, percentage depth dose, and output factor of the Siemens Primus linear accelerator. J Appl Clin Med Phys 4(4):300-306, 2003. PMID: 14604419.
50. Kim, C-H, Reece, WD, Cho, SH. Computer simulation of radiation exposure in a S/G channel head. Trans. Am. Nucl. Soc 84:325-326, 2001.
51. Cho SH, Lowenstein JR, Balter PA, Wells NH, Hanson WF. Comparison between TG-51 and TG-21: Calibration of photon and electron beams in water using cylindrical chambers. J Appl Clin Med Phys 1(3):108-115, 2000. PMID: 11674825.
52. Cho SH, Muller-Runkel R, Hanson WF. Determination of the tissue attenuation factor along two major axes of a high dose rate (HDR) 192Ir source. Med Phys 26(8):1492-1497, 1999. PMID: 10501048.
53. Cho SH, Reece WD. Monte Carlo calculations of the dose backscatter factor for monoenergetic electrons. Phys Med Biol 44(1):13-26, 1999. PMID: 10071872.
54. Cho SH, Reece WD, Poston JW, Sr. Calculation of the dose distribution in water from 71Ge K-shell x-rays. Phys Med Biol 42(6):1023-1032, 1997. PMID: 9194126.
55. Muller-Runkel R, Cho SH. Evaluation of a commercial three-dimensional electron pencil beam algorithm. Med Phys 24(1):91-101, 1997. PMID: 9029543.
56. Cho SH, Muller-Runkel R. Validity of the interval method for the determination of the anisotropy factor of high dose rate 192Ir sources. Int J Radiat Oncol Biol Phys 37(2):483-487, 1997. PMID: 9069325.
57. Muller-Runkel R, Cho SH. Anisotropy measurements of a high dose rate Ir-192 source in air and in polystyrene. Med Phys 21(7):1131-1134, 1994. PMID: 7968845.
58. Cho SH, Muller-Runkel R. Effect of anisotropy corrections on the dynamic dose calculations in high dose rate (HDR) brachytherapy. Phys Med Biol 39(7):1181-1188, 1994. PMID: 15552105.

Books (edited and written)

1. Cho SH, Krishnan S. Cancer Nanotechnology: Principles and Applications in Radiation Oncology. In: Imaging in Medical Diagnosis and Therapy. Ed(s) SH Cho, S Krishnan. 1st. Taylor & Francis Books, LLC: Boca Raton, FL, 296, 2013.