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Sanjay S. Shete, Ph.D.

Present Title & Affiliation

Primary Appointment

Barnhart Family Distinguished Professor in Targeted Therapies, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston
Director, Program in Biostatistics, Bioinformatics, and Systems Biology, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Chief, Behavioral and Social Statistics, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
Adjunct Faculty, Department of Statistics, Rice University, Houston, TX
Adjunct Member of Graduate Faculty, Texas A&M University, College Station, TX

Bio Statement

Sanjay Shete, Ph.D., is Genetic Epidemiologist with interests in developing statistical methods for genetic data. He is Section Chief of Behavioral and Social Statistics in the division of Quantitative Sciences. He currently serves as the principal investigator for a Genome-wide Association Study of Head and Neck Cancer (5R01CA131324) and is principal investigator (with Dr. Reyes-Gibby) for a Molecular Epidemiology of Neuropathic Pain in Head and Neck Cancer (1R01DE022891). He is also the principal investigator (with Dr. Chang) for NIDA funded R25 training grant on Innovative Multidisciplinary Education: The Statistical Genetics of Addiction 5R25DA026120). His ability to design and undertake creative genetic epidemiological studies in collaboration with other scientists is evidenced by the range of genetic investigations of complex disorders in which he has been involved. Dr. Shete is currently director of the Biostatistics, Bioinformatics and Systems Biology program at the Graduate School of Biomedical Sciences. Dr. Shete has institutional leadership responsibilities as vice-chair of one of the Institutional Review Boards. He was a member of Ethical, Legal and Social Issues Committee and currently a member of the scientific program committee of the International Genetic Epidemiology Society. He was a chartered member of the Cardiovascular and Sleep Epidemiology Study Section for National Institute of Health. He is a fellow of the American Statistical Association. Currently, he is the Editor-in-Chief of the Genetic Epidemiology Journal.

Research Interests

  • Statistical Methods in Genetics
  • Head and Neck Cancer Epidemiology
  • Gene-Gene and Gene-Environment Interactions in Population Studies 
  • Genomic Imprinting
  • Genetic Epidemiology of Familial Glioma
  • Haplotype Reconstruction and Analysis Methods
  • Epidemiological Methods
  • Genetic Segregation and Linkage Analysis
  • Genomewide Association Studies

Office Address

The University of Texas MD Anderson Cancer Center
Department of Biostatistics, Unit 1411
1400 Pressler Dr.
Unit Number: 1340
Houston, TX 77030
Room Number: FCT4.6002

Education & Training

Degree-Granting Education

1998 The University of Georgia, Athens, GA, PHD, Statistics
1993 Indian Statistical Institute, Calcutta, West Bengal, India, Research Scholar in Statistics, Statistics
1990 Shivaji University, Kolhapur, Maharashtra, India, Master of Philosophy, Statistics
1989 Shivaji University, Kolhapur, Maharashtra, India, MS, Statistics
1987 Shivaji University, Kolhapur, Maharashtra, India, BS, Statistics

Postgraduate Training

2013-2014 Leadership, Faculty Leadership Academy, MD Anderson Cancer Center, Houston, TX

Honors and Awards

2014-present Barnhart Family Distinguished Professorship in Targeted Therapies
2014 Fellow, Royal Statistical Society
2014 IGES Leadership Award, International Genetic Epidemiology Society
2012 Fellow, American Statistical Association
2011-present Editor-in-Chief, Genetic Epidemiology
2010-present Member, Program Committee of International Genetic Epidemiology Society
2010 Nominee, Distinguished Faculty Mentor Award
2009 Nominee, 5th Annual Robert M. Chamberlain Distinguished Mentor Award
2008-2012 Chartered Member, Cardiovascular and Sleep Epidemiology (CASE) Study Section, NHLBI, NIH
2006-2010 Associate Editor, Biometrics
2006-2009 Member, Ethical, Legal, and Social Issues Committee of International Genetic Epidemiology Society
2006 Elected Member, International Statistical Institute
2004-2005 President, Houston Area Chapter of American Statistical Association

Selected Publications

Peer-Reviewed Original Research Articles

1. Shete S, Sriram TN. Fixed precision estimator of the offspring mean in branching processes. Stochastic Processes and their Applications 77:17-33, 1998.
2. Shete S, Tiwari H, Elston RC. On estimating the heterozygosity and polymorphism information content value. Theor Popul Biol 57(3):265-271, 5/2000. PMID: 10828218.
3. Kececioglu J, Shete S, Arnold J. Reconstructing distances in physical maps of chromosomes with nonoverlapping probes. Proceedings of the International Conference on Computational Molecular Biology (RECOMB):183-192, 2000.
4. Bhandarkar, SM, Machaka SA, Shete S, Arnold J. Parallel computation for chromosome reconstruction on a cluster of workstations. International Parallel and Distributed Processing Symposium:63-70, 2000.
5. Shete S, Amos CI. A new test for linkage in affected sib pairs. GeneScreen 1:53-54, 2000.
6. Elston RC, Shete S. Adding power to Haseman and Elston’s (1972) method. GeneScreen 1:63-64, 2000.
7. Spitz MR, Wu X, Wang Y, Wang LE, Shete S, Amos CI, Guo Z, Lei L, Mohrenweiser H, Wei Q. Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Res 61(4):1354-1357, 2/2001. PMID: 11245433.
8. Bhandarkar SM, Machaka SA, Shete SS, Kota RN. Parallel computation of a maximum-likelihood estimator of a physical map. Genetics 157(3):1021-1043, 3/2001. PMCID: PMC1461556.
9. Shete SS, Chen J, Zhou X, Amos CI. Modeling age by major gene interaction by a variance component approach. Genet Epidemiol 21 Suppl1:S849-S853, 2001. PMID: 11793791.
10. Guo D, Hasham S, Kuang SQ, Vaughan CJ, Boerwinkle E, Chen H, Abuelo D, Dietz HC, Basson CT, Shete SS, Milewicz DM. Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14. Circulation 103(20):2461-2468, 5/2001. PMID: 11369686.
11. Amos CI, Shete S Gu X. Variance components analysis for genetic linkage of time to onset for disease. Genet Epidemiol 21 Suppl1:S768-S773, 2001. PMID: 11793775.
12. Bosken CH, Ko YC, Shete S, Wang TN, Chen J, Amos CI, Cheng LS. Adaptations of linkage and association methods for the study of asthma, a complex trait. Genet Epidemiol 21 Suppl1:S89-S96, 2001. PMID: 11793792.
13. Shete S, Amos CI, Hwang SJ, Strong LC. Individual-specific liability groups in genetic linkage, with applications to kindreds with Li-Fraumeni syndrome. Am J Hum Genet 70(3):813-817, 3/2002. e-Pub 1/2002. PMCID: PMC384961.
14. Qiao Y, Spitz MR, Shen H, Guo Z, Shete S, Hedayati M, Grossman L, Mohrenweiser H, Wei Q. Comparison of two host-cell reactivation assays and their application to molecular epidemiology of DNA repair capacity. Carcinogenesis 23(2):295-299, 2/2002. PMID: 11872635.
15. Shete S, Amos CI. Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting. Am J Hum Genet 70(3):751-757, 3/2002. e-Pub 2/2002. PMCID: PMC384951.
16. Wu X, Zhao H, Amos CI, Shete S, Makan N, Hong WK, Kadlubar FF, Spitz MR. Lung Cancer susceptibility associated with p53 genotypes and haplotypes in various ethnic groups. J Natl Cancer Inst 94(9):681-690, 5/2002. PMID: 11983757.
17. Fernández JR, Etzel C, Beasley TM, Shete S, Amos CI, Allison DB. Improving the power of sib pair quantitative trait loci detection by phenotype winsorization. Hum Hered 53(2):59-67, 2002. PMID: 12037405.
18. Zheng Y, Shen H, Sturgis EM, Wang LE, Shete S, Spitz MR, Wei Q. Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study. Cancer Epidemiol Biomarkers Prev 11(7):640-645, 7/2002. PMID: 12101111.
19. Shete S, Sriram TN. Estimation theory for multitype branching processes with immigration. Journal Sankhya Series A 65:107-121, 2003.
20. Shete S. A note on the optimal measure of allelic association. Ann Hum Genet 67(Pt2):189-191, 3/2003. PMID: 12675694.
21. Shete S, Jacobs KB, Elston RC. Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered 55(2-3):79-85, 2003. PMID: 12931046.
22. Hasham SN, Willing MC, Guo DC, Muilenburg A, He R, Tran VT, Scherer SE, Shete SS, Milewicz DM. Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25. Circulation 107(25):3184-3190, 7/2003. e-Pub 6/2003. PMID: 12821554.
23. Etzel CJ, Shete S, Beasley TM, Fernandez JR, Allison DB, Amos CI. Effect of Box-Cox transformation on power of Haseman-Elston and maximum-likelihood variance components tests to detect quantitative trait Loci. Hum Hered 55(2-3):108-116, 2003. PMID: 12931049.
24. Zeng Y, Shen, H, Sturgis EM, Wang L-E, Shete S, Spitz MR, Wei Q. Haplotypes of two variants in p16 (CDKD2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck-a case-control study: reply letter. Cancer Epidemiology, Biomarkers and Prevention 12(1):72-72, 2003. PMID: 12101111.
25. Shete S. Uniformly minimum variance unbiased estimation of gene diversity. J Hered 94(5):421-424, Sep-Oct, 9/2003. PMID: 14557396.
26. Gorlova OY, Amos CI, Wang NW, Shete S, Turner ST, Boerwinkle E. Genetic linkage and imprinting effects on body mass index in children and young adults. Eur J Hum Genet 11(6):425-432, 6/2003. PMID: 12774034.
27. Shete S, Zhou X, Amos CI. Genomic imprinting and linkage test for quantitative-trait Loci in extended pedigrees. Am J Hum Genet 73(4):933-938, 10/2003. e-Pub 9/2003. PMCID: PMC1180613.
28. Wang Y, Spitz MR, Zhu Y, Dong Q, Shete S, Wu X. From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. DNA Repair (Amst) 2(8):901-908, 8/2003. PMID: 12893086.
29. Amos CI, Shete S, Chen J, Yu RK. Positional identification of microdeletions with genetic markers. Hum Hered 56(1-3):107-118, 2003. PMID: 14614244.
30. Liu E, Percy MJ, Amos CI, Guan Y, Shete S, Stockton DW, McMullin MF, Polyakova LA, Ang SO, Pastore YD, Jedlickova K, Lappin TR, Gordeuk V, Prchal JT. The worldwide distribution of the VHL 598C>T mutation indicates a single founding event. Blood 103(5):1937-1940, 3/2004. e-Pub 11/2003. PMID: 14604959.
31. Xu H, Wu X, Spitz MR, Shete S. Comparison of haplotype inference methods using genotypic data from unrelated individuals. Hum Hered 58(2):63-68, 2004. PMID: 15711085.
32. Strom SS, Gu Y, Zhang H, Troncoso P, Babaian RJ, Pettaway CA, Shete S, Spitz MR, Logothetis CJ. Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients. Prostate 60(4):343-351, 9/2004. PMID: 15264247.
33. Meng S, Tripathy D, Shete S, Ashfaq R, Haley B, Perkins S, Beitsch P, Khan A, Euhus D, Osborne C, Frenkel E, Hoover S, Leitch M, Clifford E, Vitetta E, Morrison L, Herlyn D, Terstappen LW, Fleming T, Fehm T, Tucker T, Lane N, Wang J, Uhr J. HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A 101(25):9393-9398, 6/2004. e-Pub 6/2004. PMCID: PMC438987.
34. Huang Q, Shete S, Amos CI. Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Genet 75(6):1106-1112, 12/2004. e-Pub 10/2004. PMCID: PMC1182145.
35. Shete S, Beasley TM, Etzel CJ, Fernández JR, Chen J, Allison DB, Amos CI. Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection. Behav Genet 34(2):153-159, 3/2004. PMID: 14755180.
36. Meng S, Tripathy D, Frenkel EP, Shete S, Naftalis EZ, Huth JF, Beitsch PD, Leitch M, Hoover S, Euhus D, Haley B, Morrison L, Fleming TP, Herlyn D, Terstappen LW, Fehm T, Tucker TF, Lane N, Wang J, Uhr JW. Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res 10(24):8152-8162, 12/2004. PMID: 15623589.
37. Xu H, Shete S. Effects of population structure on genetic association studies. BMC Genet 6 Suppl1:S109 (5 pages), 2005. PMCID: PMC1866830.
38. Neumann AS, Lyons HJ, Shen H, Liu Z, Shi Q, Sturgis EM, Shete S, Spitz MR, El-Naggar A, Hong WK, Wei Q. Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer 115(1):131-136, 5/2005. PMID: 15688408.
39. Pannu H, Fadulu VT, Chang J, Lafont A, Hasham SN, Sparks E, Giampietro PF, Zaleski C, Estrera AL, Safi HJ, Shete S, Willing MC, Raman CS, Milewicz DM. Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections. Circulation 112(4):513-520, 7/2005. e-Pub 7/2005. PMID: 16027248.
40. Shete S, Yu R. Genetic imprinting analysis for alcoholism genes using variance components approach. BMC Genet 6 Suppl1:S161 (4 pages), 2005. PMCID: PMC1866772.
41. Xu H, Spitz MR, Amos CI, Shete S. Complex segregation analysis reveals a multigene model for lung cancer. Hum Genet 116(1-2):121-127, 1/2005. e-Pub 11/2004. PMID: 15599767.
42. Wu CC, Shete S, Amos CI. Linkage analysis of affected sib pairs allowing for parent-of-origin effects. Ann Hum Genet 69(Pt1):113-126, 1/2005. PMID: 15638832.
43. Yu R, Shete S. Analysis of alcoholism data using support vector machines. BMC Genet 6 Suppl1:S136 (5 pages), 2005. PMCID: PMC1866800.
44. Bachinski LL, Olufemi SE, Zhou X, Wu CC, Yip L, Shete S, Lozano G, Amos CI, Strong LC, Krahe R. Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23. Cancer Res 65(2):427-431, 1/2005. PMID: 15695383.
45. Shete S, Zhou X. Parametric approach to genomic imprinting analysis with applications to Angelman's syndrome. Hum Hered 59(1):26-33, 2005. e-Pub 3/2005. PMID: 15802919.
46. Huang Q, Shete S, Swartz M, Amos CI. Examining the effect of linkage disequilibrium on multipoint linkage analysis. BMC Genet 6 Suppl1:S83 (5 pages), 2005. PMCID: PMC1866697.
47. Pannu H, Kim DH, Seaman CR, Van Ginhoven G, Shete S, Milewicz DM. Lack of an association between the angiotensin-converting enzyme insertion/deletion polymorphism and intracranial aneurysms in a Caucasian population in the United States. J Neurosurg 103(1):92-96, 7/2005. PMID: 16121979.
48. Wu CC, Shete S. Analysis of genes for alcoholism using two-disease-locus models. BMC Genet 6 Suppl1:S149 (4 pages), 2005. PMCID: PMC1866786.
49. Selvan MS, Ross MW, Nagaraj S, Etzel CJ, Shete S. Perception among upper middle class adolescent in Bombay regarding sex and sexuality. Indian J Public Health 49(4):250-251, Oct-Dec, 10/2005. PMID: 16479912.
50. Wu CC, Shete S, Amos CI, Strong LC. Joint Effects of Germ-Line p53 Mutation and Sex on Cancer Risk in Li-Fraumeni Syndrome. Cancer Res 66(16):8287-8292, 8/2006. PMID: 16912210.
51. Pannu H, Kim DH, Guo D, King TM, Van Ginhoven G, Chin T, Chang K, Qi Y, Shete S, Milewicz DM. The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. J Neurosurg 105(3):418-423, 9/2006. PMID: 16961137.
52. Zhou X, Shete S. Linkage Analysis of Variation in Gene Expression Using a Variance-Components Approach with Imprinting. Proceedings of the Genetic Analysis Workshop(5):59-61, 2006.
53. Zaggar UA, Shete S, Kachroo S. Comparison of Multifactor Dimensionality Reduction Techniques. Proceedings of the Genetic Analysis Workshop(6):73-74, 2006.
54. Tran-Fadulu V, Chen JH, Lemuth D, Neichoy BT, Yuan J, Gomes N, Sparks E, Kramer LA, Guo D, Pannu H, Braverman AC, Shete S, Milewicz DM. Familial thoracic aortic aneurysms and dissections: three families with early-onset ascending and descending aortic dissections in women. Am J Med Genet A 140(11):1196-1202, 6/2006. PMID: 16646045.
55. Shete S, Zhou X. TLINKAGE-IMPRINT: a model-based approach to performing two-locus genetic imprinting analysis. Hum Hered 62(3):145-156, 2006. e-Pub 10/2006. PMID: 17057404.
56. Lu J, Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F, Hunt KK, Singletary SE, Ross MI, Wang LE. Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years. Carcinogenesis 27(11):2209-2216, 11/2006. e-Pub 5/2006. PMID: 16714331.
57. Wu CC, Chen W, Amos CI, Shete S. Two-Locus SNP Genome-Wide Scan in Caucasian Families with Rheumatoid Arthritis. Proceedings of the Genetic Analysis Workshop(7):67-70, 2006.
58. Shete S, Chen W, Swartz M, Zhou X, Lu Y, Yu R, Amos C, Wu CC. Joint linkage and Imprinting analyses in Rheumatoid Arthritis Families. Proceedings of the Genetic Analysis Workshop(10):53-55, 2007. PMCID: PMC2367552.
59. Meng S, Tripathy D, Shete S, Ashfaq R, Saboorian H, Haley B, Frenkel E, Euhus D, Leitch M, Osborne C, Clifford E, Perkins S, Beitsch P, Khan A, Morrison L, Herlyn D, Terstappen LW, Lane N, Wang J, Uhr J. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci U S A 103(46):17361-17365, 11/2006. e-Pub 11/2006. PMCID: PMC1838539.
60. Lu J, Wei Q, Bondy ML, Yu TK, Li D, Brewster A, Shete S, Sahin A, Meric-Bernstam F, Wang LE. Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. Cancer 107(9):2245-2253, 11/2006. PMID: 17063466.
61. Xu H, Shete S. Mixed-effects logistic approach for association following linkage scan for complex disorders. Ann Hum Genet 71(Pt2):230-237, 3/2007. e-Pub 10/2006. PMID: 17032287.
62. Osio A, Tan L, Chen SN, Lombardi R, Nagueh SF, Shete S, Roberts R, Willerson JT, Marian AJ. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. Circ Res 100(6):766-768, 3/2007. e-Pub 3/2007. PMCID: PMC2775141.
63. Spitz MR, Hong WK, Amos CI, Wu X, Schabath MB, Dong Q, Shete S, Etzel CJ. A risk model for prediction of lung cancer. J Natl Cancer Inst 99(9):715-726, 5/2007. PMID: 17470739.
64. Chen WV, Amos CI, Etzel CJ, Shete S, Gregersen PK. Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families. BMC Proc 1 Suppl1:S97, 2007. e-Pub 12/2007. PMCID: PMC2367594.
65. Reyes-Gibby CC, Shete S, Rakvåg T, Bhat SV, Skorpen F, Bruera E, Kaasa S, Klepstad P. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain 130(1-2):25-30, 7/2007. e-Pub 12/2006. PMCID: PMC1995596.
66. Yu R, Dehoff K, Amos CI, Shete S. Seeking gene relationships in gene expression data using support vector machine regression. BMC Proc Suppl:S51, 2007. e-Pub 12/2007. PMCID: PMC2367560.
67. Zhou X, Chen W, Swartz MD, Lu Y, Yu R, Amos CI, Wu CC, Shete S. Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data. BMC Proc Suppl:S53, 2007. e-Pub 12/2007. PMCID: PMC2367552.
68. Shete S, Elston RC, Lu Y. A novel approach to detect parent-of-origin effects from pedigree data with application to Beckwith-Wiedemann syndrome. Ann Hum Genet 71(Pt 6):804-814, 11/2007. e-Pub 6/2007. PMID: 17578507.
69. Swartz MD, Shete S. The null distribution of stochastic search gene suggestion: a Bayesian approach to gene mapping. BMC Proc Suppl:S113, 2007. e-Pub 12/2007. PMCID: PMC2367497.
70. Ghosh S, Babron MC, Amos CI, Briollais L, Chen P, Chen WV, Chiu WF, Drigalenko E, Etzel CJ, Hamshere ML, Holmans PA, Margaritte-Jeannin P, Lebrec JJ, Lin S, Lin WY, Mandhyan DD, Nishchenko I, Schaid DJ, Seguardo R, Shete S, Taylor K, Tayo BO, Wan S, Wei LY, Wu CO, Yang XR. Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience. Genet Epidemiol 31 Suppl:S86-95, 2007. PMID: 18046767.
71. Gorlova OY, Lei L, Zhu D, Weng SF, Shete S, Zhang Y, Li WD, Price RA, Amos CI. Imprinting detection by extending a regression-based QTL analysis method. Hum Genet 122(2):159-174, 9/2007. e-Pub 6/2007. PMID: 17562082.
72. Daw EW, Chen SN, Czernuszewicz G, Lombardi R, Lu Y, Ma J, Roberts R, Shete S, Marian AJ. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. Hum Mol Genet 16(20):2463-2471, 10/2007. e-Pub 7/2007. PMCID: PMC2772866.
73. Reyes-Gibby CC, Spitz M, Wu X, Merriman K, Etzel C, Bruera E, Kurzrock R, Shete S. Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A. Cancer Epidemiol Biomarkers Prev 16(12):2745-2751, 12/2007. PMID: 18086782.
74. Guo DC, Pannu H, Tran-Fadulu V, Papke CL, Yu RK, Avidan N, Bourgeois S, Estrera AL, Safi HJ, Sparks E, Amor D, Ades L, McConnell V, Willoughby CE, Abuelo D, Willing M, Lewis RA, Kim DH, Scherer S, Tung PP, Ahn C, Buja LM, Raman CS, Shete SS, Milewicz DM. Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. Nat Genet 39(12):1488-1493, 12/2007. e-Pub 11/2007. PMID: 17994018.
75. Malmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F, Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H, Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. GLIOGENE an International Consortium to Understand Familial Glioma. Cancer Epidemiol Biomarkers Prev 16(9):1730-1734, 9/2007. PMID: 17855690.
76. Falk CT, Finch SJ, Kim W, Mukhopadhyay ND, Gong B, Hinrichs A, Li X, Liu X, Malhotra A, Mehta T, Page G, Rao S, Saccone N, Shete S, Yang Y, Yu R, Zhao JH, Zhou X. Data mining of RNA expression and DNA genotype data: presentation group 5 contributions to Genetic Analysis Workshop 15. Genet Epidemiol 31 Suppl:S43-50, 2007. PMID: 18046764.
77. Wu CC, Grimson RC, Amos CI, Shete S. Statistical methods for anomalous discrete time series based on minimum cell count. Biom J 50(1):86-96, 2/2008. PMID: 17853406.
78. Daw EW, Lu Y, Marian AJ, Shete S. Identifying Modifier Loci in Existing Genome Scan Data. Ann Hum Genet 72(Pt 5):670-675, 9/2008. e-Pub 5/2008. PMCID: PMC4003897.
79. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40(5):616-622, 5/2008. e-Pub 4/2008. PMCID: PMC2713680.
80. Wang J, Shete S. A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases. Am J Hum Genet 83(1):53-63, 7/2008. e-Pub 6/2008. PMCID: PMC2443842.
81. Reyes-Gibby CC, El Osta B, Spitz MR, Parsons H, Kurzrock R, Wu X, Shete S, Bruera E. The Influence of polymorphisms in cytokine genes on pain and response to analgesia in lung cancer patients referred for Palliative Treatment: TNF-308 G/A, IL-6-174 G/c, and IL-8-251T/A. Cancer Epidemiol Biomarkers Prev 17(11):3262-3267, 11/2008. PMCID: PMC3398799.
82. Wilkinson AV, Shete S, Prokhorov AV. The moderating role of parental smoking on their children's attitudes toward smoking among a predominantly minority sample: a cross-sectional analysis. Subst Abuse Treat Prev Policy 3(1):18, 2008. PMCID: PMC2490678.
83. Swartz MD, Yu RK, Shete S. Finding Factors Influencing Risk: Comparing Variable Selection Methods Applied to Logistic Regression Models of Cases and Controls. Stat Med 27(29):6158-6174, 12/2008. PMCID: PMC3044475.
84. Wang J, Shete S. Is the tail strength measure more powerful for genetic association test? And Tail Strength to Combine Two P-values: Their Correlation Cannot Be Ignored: Authors reply. The American Journal of Human Genetics 84:298-300, 2009. PMCID: PMC2443842.
85. Wilkinson AV, Shete S, Vasudevan V, Prokhorov AV, Bondy ML, Spitz MR. Influence of subjective social status on the relationship between positive outcome expectations and experimentation with cigarettes. J Adolesc Health 44(4):342-348, 4/2009. e-Pub 10/2008. PMCID: PMC2705959.
86. Guo DC, Papke CL, Tran-Fadulu V, Regalado ES, Avidan N, Johnson RJ, Kim DH, Pannu H, Willing MC, Sparks E, Pyeritz RE, Singh MN, Dalman RL, Grotta JC, Marian AJ, Boerwinkle EA, Frazier LQ, LeMaire SA, Coselli JS, Estrera AL, Safi HJ, Veeraraghavan S, Muzny DM, Wheeler DA, Willerson JT, Yu RK, Shete S, Scherer SE, Raman CS, Buja LM, Milewicz DM. Mutations in Smooth Muscle Alpha-Actin (ACTA2) cause early onset coronary artery disease, stroke and moyamoya disease, along with thoracic aortic aneurysms and dissections. Am J Hum Genet 84(5):617-627, 5/2009. e-Pub 4/2009. PMCID: PMC2680995.
87. Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier M, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR. Genetic and non-genetic covariates of pain severity in patients with adenocarcinoma of the pancreas: Assessing the influence of cytokine genes. J Pain Symptom Manage 38(6):894-902, 2009. e-Pub 12/2009. PMCID: PMC2795073.
88. Wu CC, Shete S, Chen WV, Peng B, Lee AT, Ma J, Gregersen PK, Amos CI. Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis. Hum Genet 126(2):303-315, 8/2009. e-Pub 5/2009. PMCID: PMC2992885.
89. Reyes-Gibby CC, Morrow PK, Buzdar A, Shete S. Chemotherapy-induced peripheral neuropathy as a predictor of neuropathic pain in breast cancer patients previously treated with paclitaxel. J Pain 10(11):1146-1150, 11/2009. PMCID: PMC2783933.
90. Reyes-Gibby CC, Spitz MR, Yennurajalingam S, Swartz M, Gu J, Wu X, Bruera E, Shete S. The role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer Epidemiol Biomarkers Prev 18(10):2636-2642, 10/2009. e-Pub 9/2009. PMCID: PMC2759856.
91. Wilkinson AV, Spitz MR, Prokhorov AV, Bondy ML, Shete S, Sargent JD. Exposure to smoking imagery in the movies and experimenting with cigarettes among Mexican heritage youth. Cancer Epidemiol Biomarkers Prev 18(12):3435-3443, 12/2009. PMCID: PMC2791895.
92. Agarwal SK, Gourh P, Shete S, Paz G, Divecha D, Reveille JD, Assassi S, Tan FK, Mayes MD, Arnett FC. Association of Interleukin-23 Receptor Polymorphisms with Anti-topoismerase-I Positivity and Pulmonary Hypertension in Systemic Sclerosis. J Rheumatol 36(12):2715-2723, 12/2009. e-Pub 11/2009. PMCID: PMC2895677.
93. Gourh P, Agarwal SK, Divecha D, Assassi S, Paz G, Arora-Singh RK, Reveille JD, Shete S, Mayes MD, Arnett FC, Tan FK. Polymorphisms in TBX21 (T-bet) and STAT4 increase risk for Systemic Sclerosis: evidence of gene-gene interaction and alterations in TH1/Th2 cytokines. Arthritis Rheum 60(12):3794-3806, 12/2009. PMCID: PMC2998060.
94. Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M, Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A, Zelenika D, Andersson U, Henriksson R, Bergenheim AT, Feychting M, Lönn S, Ahlbom A, Schramm J, Linnebank M, Hemminki K, Kumar R, Hepworth SJ, Price A, Armstrong G, Liu Y, Gu X, Yu R, Lau C, Schoemaker M, Muir K, Swerdlow A, Lathrop M, Bondy M, Houlston RS. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet 41(8):899-904, 8/2009. e-Pub 7/2009. PMID: 19578367.
95. Arnett FC, Gourh P, Shete S, Ahn CW, Honey R, Agarwal SK, Tan FK, McNearney T, Fischbach M, Fritzler MJ, Mayes MD, Reveille JD. Major Histocompatibility Complex (MHC) Class II Alleles, Haplotypes, and Epitopes which Confer Susceptibility or Protection in the Fibrosing Autoimmune Disease Systemic Sclerosis: Analyses in 1300 Caucasian, African-American and Hispanic Cases and 1000 Controls. Annals of the Rheumatic Disease 69(5):822-827, 2010. PMCID: PMC2916702.
96. Gourh P, Agarwal SK, Martin E, Divecha D, Rueda B, Bunting H, Assassi S, Paz G, Shete S, McNearney T, Draeger H, Reveille JD, Radstake TR, Simeon CP, Rodriguez L, Vicente E, Gonzalez-Gay MA, Mayes MD, Tan FK, Martin J, Arnett FC. Association of the C8orf13-BLK Region with Systemic Sclerosis in North-American and European Populations. J Autoimmun 34(2):155-162, 3/2010. e-Pub 9/2009. PMCID: PMC2821978.
97. Liu Y, Shete S, Etzel CJ, Scheurer M, Alexiou G, Armstrong G, Tsavachidis S, Liang FW, Gilbert M, Aldape K, Armstrong T, Houlston R, Hosking F, Robertson L, Xiao Y, Wiencke J, Wrensch M, Andersson U, Melin BS, Bondy M. Polymorphisms of LIG4, BTBD2, HMGA2 and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival. J Clin Oncol 28(14):2467-2474, 2010. PMCID: PMC2881725.
98. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating Effects of Smoking and Chronic Obstructive Airway Disease on the Relationship between the CHRNA5-A3 Genetic Locus and Lung Cancer Risk. Cancer 116(14). e-Pub 4/2010. PMCID: PMC3073819.
99. Wu CC, Grimson RC, Shete S. Statistical Tests for Heterogeneity of Frequencies based on Extreme Values. Communications in Statistics - Simulation and Computation 39(3):612-623, 3/2010. e-Pub 2/2010.
100. Liu Y, Shete S, Hosking FJ, Robertson LB, Bondy ML, Houlston RS. New insights into susceptibility to glioma. Arch Neurol 67(3):275-278, 3/2010. PMID: 20212223.
101. Wu CC, Strong LC, Shete S. Effects of Measured Susceptibility Genes on Cancer Risk in Family Studies. Hum Genet 127(3):349-357, 3/2010. e-Pub 12/2009. PMCID: PMC2918266.
102. Liu Y, Shete S, Wang L-E, El-Zein R, Etzel C, Liang F-W, Armstrong G, Tsavachidis S, Gilbert M, Aldape K, Xing J, Wu X, Wei Q, Bondy M.. Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. Carcinogenesis 10:1762-1769, 7/2010. PMCID: PMC2981459.
103. Reyes-Gibby C, Morrow PK; Bennett MI, Jensen MP, Shete S. Neuropathic pain in breast cancer survivors: Using the ID Pain as a screening tool. Journal of Pain and Symptom Management 39(5):882-889, 2010. PMCID: PMC2872632.
104. Liu Y, Shete S, Hosking F, Robertson L, Houlston R, Bondy M. Genetic Advances in Glioma: Susceptibility Genes and Networks. Curr Opin Genet Dev 20(3). e-Pub 3/2010. PMCID: PMC2885452.
105. Wang J, Shete S. Using both cases and controls for testing hardy-weinberg proportions in a genetic association study. Hum Hered 69(3):212-8, 2010. e-Pub 3/2010. PMCID: PMC2918648.
106. Robertson L, Armstrong G, Olver B, Lloyd A, Shete S, Lau C, Claus E, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Bernstein J, Olston S, Jenkins R, Yang P, Rynerason A, Wrensch M, McCoy L, Wienkce J, McCarthy B, Davis F, Vick N, Johansen C, Bodtcher H, Sadetzki S, Bruchim R, Yechezkel G, Andersson U, Melin B, Bondy M, Houlston R. Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation. Familial Cancer 9(3). e-Pub 5/2010. PMCID: PMC2922430.
107. Wang L, Guo D, Cao J, Gong L, Kamm K, Regalado E, Li L, Shete S, He W, Zhu M, Offermanns S, Gilchrist D, Elefteriades J, Stull J, Milewicz D. Mutations in myosin light chain kinase (MLCK) cause familial aortic dissections. The American Journal of Human Genetics 87(5):701-707, 2010. e-Pub 11/2010. PMCID: PMC2978973.
108. Scheurer ME, Etzel CJ, Liu M, Barnholtz-Sloan J, Wiklund F, Tavelin B, Wrensch MR, Melin BS, Bondy ML, GLIOGENE Consortium.. Familial aggregation of glioma: a pooled analysis. Am J Epidemiol 172(10). e-Pub 2010. PMCID: PMC3025634.
109. Schwartzbaum J, Xiao Y, Liu Y, Tsavachidis S, Berger M, Bondy M, Chang J, Chang S, Decker P, Ding B, Hepworth S, Houlston R, Hosking F, Jenkins R, Kosel M, McCoy L, McKinney P, Muir K, Patoka J, Prados M, Rice T, Robertson L, Schoemaker M, Shete S, Swerdlow A, Wiemels J, Wiencke J, Yang P, Wrensch M. Inherited variation in immune genes and pathways and glioblastoma risk. Carcinogenesis 10:1770-1777, 10/2010. PMCID: PMC2950934.
110. Dobbins S, Hosking F, Shete S, Armstrong G, Swerdlow A, Liu Y, Yu R, Lau C, Schoemaker M, Hepworth S, Muir K, Bondy M, Houlston R. Allergy and glioma risk: test of association by genotype. International Journal of Cancer 128(7):1736-1740, 2011. PMID: 20503266.
111. Wilkinson AV, Shete S, Spitz MR, Swann A. Sensation seeking, risk behaviors and alcohol consumption among Mexican origin youth. Journal of Adolescent Health 48(1):65-72, 2011. PMCID: PMC3148938.
112. Swartz MD, Peng B, Reyes-Gibby C, Shete S. Using Ascertainment for Targeted Resequencing to Increase Power to Identify Causal Variants. Statistics and Its Interface 4:285-294, 2011. PMCID: PMC3316326.
113. Wang J, Shete S. A Powerful Hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study. BMC Genetics 12(1):3, 1/2011. PMCID: PMC3024976.
114. Huang Z, Wang J, Wu C, Houlston R, Bondy M, Shete S. False-Negative-Rate Based Approach for Selecting Top Single-Nucleotide Polymorphisms in the First Stage of a Two-Stage Genome-Wide Association Study. Statistics and Its Interface 4:359-371, 2011. PMCID: PMC3467022.
115. Guo D, Regalado E, Minn C, Tran-Fadulu V, Coney J, Cao J, Wang M, Yu R, Estrera A, Safi H, Shete S, Milewicz D. Familial thoracic aortic aneurysms and dissections: identification of a novel locus for stable aneurysms with a low risk for progression to aortic dissection. Circulation: Cardiovascular Genetics 4(1):36-42, 2011. PMCID: PMC3739448.
116. Wang J, Shete S. Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary disease. Genetic Epidemiology 35(3):190-200, 2011. PMCID: PMC3063504.
117. Wu C, Krahe R, Lozano G, Zhang B, Wilson C, Jo E-J, Amos C, Shete S, Strong L. Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. Human Genetics 129(6):663-673, 2011. PMID: 21305319.
118. Kang G, Gao G, Shete S, Redden DT, Chang B-L, Rebbeck TR, Barnholtz-Sloan J, Pajewski NM, Allison DB. Capitalizing on admixture in genome-wide association studies: A two-stage testing procedure and application to height in African Americans. Frontiers in Statistical Genetics and Methodology 2:10.3389/fgene.2011.00011, 2011. PMCID: PMC3132882.
119. Gu J, Chen M, Shete S, Amos C, Kamat A, Ye Y, Lin J, Dinney C, Wu X.. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prevention Research 4(4):514-521, 2011. PMCID: PMC3076128.
120. Sanson M*, Hosking F*, Shete S*, Zelenika D, Dobbins S, Ma Y, Enciso-Mora V, Idbaih A, Delattre J, Hoang-Xuan K, Marie Y, Boisselier B, Carpentier C, Wang X, Di Stefano A, Labussiere M, Gousias K, Schramm J, Boland A, Lechner D, Gut I, Armstrong G, Liu Y, Yu R, Lau C, Di Bernardo M, Robertson L, Muir K, Hepworth S, Swerdlow A, Schoemaker M, Wichmann H, Müller M, Schreiber S, Franke A, Moebus S, Eisele L, Forsti A, Hemminki K, Lathrop M, Bondy M**, Houlston R**, Simon M**. Chromosome 7p11.2 (EGFR) variation influences glioma risk. Human Molecular Genetics 20(14):2897-2904, 2011. PMCID: PMC3118762.
121. Wang J, Shete S. Power and type I error results for a bias-correction approach recently shown to provide accurate odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. Genetic Epidemiology 35(7):739-743, 2011. PMCID: PMC3197800.
122. Amirian E, Scheurer M, Liu Y, DAmelio A, Houston R, Etzel C, Shete S, Swerdlow A, Schoemaker M, McKinney P, Fleming S, Muir K, Lophatananon A, Bondy M. A novel approach to exploring potential interactions among single-nucleotide polymorphisms of inflammation genes in gliomagenesis: an exploratory case-only study. Cancer Epidemiology, Biomarkers and Prevention 20(8):1683-1689, 8/2011. PMCID: PMC3904785.
123. Regalado E, Medrek S, Tran-Fadulu V, Guo D, Pannu H, Golabbakhsh H, Smart S, Chen J, Shete S, Kim D, Stern R, Braverman A, Milewicz D. Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms. American Journal of Medical Genetics 155(9):2125-2130, 2011. PMCID: PMC3739441.
124. Shete S, Lau C, Houlston R, Claus E, Barnholtz-Sloan J, Lai R, Il’yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein J, Olson S, Jenkins R, Yang P, Vick N, Wrensch M, Davis F, McCarthy B, Leung E, Davis C, Cheng R, Hosking F, Armstrong G, Liu Y, Yu R, Henriksson R, The Gliogene Consortium, Melin B, Bondy M. Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium. Cancer Research 71(24):7568-7575, 2011. PMCID: PMC3242820.
125. Wang J, Shete S. Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study. PLoS ONE 6(11):e27642, 2011. PMCID: PMC3215743.
126. Xing J, Dinney C, Shete S, Huang M, Hildebrandt M, Chen Z, Gu J. Comprehensive pathway-based interrogation of genetic variations in the nucleotide excision DNA repair pathway and risk of bladder cancer. Cancer 118(1):205-215, 2012. PMCID: PMC3178723.
127. Wilkinson A, Bondy M, Wu X, Dong Q, D'Amelio A, Prokhorov A, Pu X, Yu R, Etzel C, Shete S, Spitz M. Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. Cancer Epidemiology, Biomarkers and Prevention 21(1):228-238, 2012. PMCID: PMC3382046.
128. Reyes-Gibby C, Anderson K, Shete S, Bruera E, Yennurajalingam S. Early referral to supportive care specialists for symptom burden in lung cancer patients: a comparison of non-Hispanic Whites, Hispanics, and non-Hispanic Blacks. Cancer 118(3):856-863, 2012. PMCID: PMC3193905.
129. Reyes-Gibyy C, Anderson KO, Morrow PK, Shete S, Hassan S. Depressive symptoms and health related quality of life in breast cancer survivors. Journal of Women's Health 21(3):311-318, 2012. PMCID: PMC3326444.
130. VanderWeele T, Asomaning K, Tchetgen E, Han Y, Spitz M, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung R, Brennan P, Amos C, Christiani D, Lin X. Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. American Journal of Epidemiology 175(10):1013-1020, 2012. PMCID: PMC3353137.
131. Hartz, SM, S Short, NL Saccone, R Culverhouse, LS Chen, T Schwantes-An, H Coon, Y Han, SH Stephens, J Sun, X Chen, F Ducci, N Dueker, N Franceschini, J Frank, F Geller, D Guðbjartsson, N Hansel, C Jiang, K Keskitalo-Vuokko, J Liu, L Lyytikäinen, M Michel, R Rawal, A Rosenberger, P Scheet, JR Shaffer, A Teumer, JR Thompson, JM Vink, N Vogelzangs, A Wenzlaff, W Wheeler, X Xiangjun , BZ Yang, SH Aggen, A Balmforth, S Baumeister, T Beaty, S Bennett, A Bergen, H Boyd, U Broms, H Campbell, N Chatterjee, J Chen, YC Cheng, S Cichon, D Couper, F Cucca, D Dick, T Foroud, H Furberg, I Giegling, F Gu, A S Hall, J Hällfors, S Han, AM Hartmann, C Hayward, K Heikkilä, JK Hewitt, JJ Hottenga, M Jensen, P Jousilahti, M Kaakinen, S Kittner, B Konte, T Korhonen, MT Landi, T Laatikainen, M Leppert, SM Levy, R Mathias, DW McNeil, S Medland, G Montgomery, T Muley, T Murray, M Nauck, K North, M Pergadia, O Polasek, E Ramos, S Ripatti, A Risch, I Ruczinski, I Rudan, V Salomaa, D Schlessinger, U Styrkársdóttir, A Terracciano, M Uda, G Willemsen, X Wu, G Abecasis, K Barnes, H Bickeböller, E Boerwinkle, DI Boomsma, N Caporaso, J Duan, HJ Edenberg, C Francks, PV Gejman, J Gelernter, HJ Grabe, H Hops, MR Jarvelin, V Jorma, M Kähönen, KS Kendler, T Lehtimäki, DF Levinson, ML Marazita, J Marchini, M Melbye, B Mitchell, JC Murray, MM Nöthen, BW Penninx, O Raitakari, M Rietschel, D Rujescu, N J Samani , AR Sanders, A Schwartz, Shete S, J Shi, M Spitz, K Stefansson, G Swan, T Thorgeirsson, H Völzke, Q Wei, HE Wichmann, C Amos, N Breslau, D Cannon, M Ehringer, R Grucza, D Hatsukami, A Heath, E Johnson, J Kaprio, P Madden, NG Martin, V Stevens, JA Stitzel, RB Weiss, P Kraft, LJ Bierut. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry 69(8):854-860, 8/2012. PMCID: PMC3482121.
132. Wang L, Han C, Xiong P, Bondy M, Yu T, Brewster A, Shete S, Arun B, Buchholz T, Wei Q. Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. Breast Cancer Research and Treatment 132(3):1147-1155, 2012. PMCID: PMC3523666.
133. Chen L, Saccone N, Culverhouse R, Bracci P, Chen C, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma J, Przybeck T, Sanders A, Smith J, Sung Y, Wenzlaff A, Wu C, Yoon D, Bergen A, Chen Y, Cheng Y, Cho Y, David S, Duan J, Eaton C, Furberg H, Goate A, Gu D, Hansen H, Hartz S, Hu Z, Kim Y, Kittner S, Levinson D, Mosley T, Payne T, Rao D, Rice J, Rice T, Schwantes-An T, Shete S, Shi J, Spitz M, Sun Y, Tsai F, Wang J, Wrensch M, Xian H, Gejman P, He J, Hunt S, Kardia S, Li M, Lin D, Mitchell B, Park T, Schwartz A, Shen H, Wiencke J, Wu J, Yokota J, Amos C, Bierut L. Smoking and genetic risk variation across populations of European, Asian, and African ancestry-A meta-analysis of chromosome 15q25. Genetic Epidemiology 36(4):340-351, 2012. PMCID: PMC3387741.
134. Wang J, Spitz MR, Amos CI, Wu X, Wetter D, Cinciripini P, Shete S. Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk. PLoS ONE 7(10):e47705, 2012. PMCID: PMC3471886.
135. Liu Y, Melin B, Rajaraman P, Wang Z, Linet M, Shete S, Amos C, Lau C, Scheurer M, Armstrong G, Houlston R, Hosking F, Claus E, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein J, Olson S, Jenkins R, LaChance D, Vick N, Wrensch M, Davis F, McCarthy B, Andersson U, Chanock S, The Gliogene Consortium, Bondy M. Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma. Human Genetics 131(9):1507-1517, 2012. PMCID: PMC3604903.
136. Wang J, Shete S. Analysis of Secondary Phenotype Involving the Interactive Effect of the Secondary Phenotype and Genetic Variants on the Primary Disease. Annals of Human Genetics 76(6):484-499, 2012. PMCID: PMC3472120.
137. Sun X, Vengoechea J, Elston R, Chen Y, Amos C, Armstrong G, Bernstein J, Claus E, Davis F, Houlston R, Ilyaosova D, Jenkins R, Johansen C, Lai R, Lau C, Liu Y, McCarthy B, Olson S, Sadetzki S, Schildkraut, Shete S, Yu R, Vick N, Merrell R, Wrensch M, Yang P, Melin B, Bondy M, Barnholtz-Sloan J. A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma. Cancer Epidemiology, Biomarkers and Prevention 21(12):2242-2251, 12/2012. PMCID: PMC3518573.
138. Rajaraman P, Melin B, Wang Z, McKean-Cowdin R, Michaud D, Wang S, Bondy M, Houlston R, Jenkins R, Wrensch M, Yeager M, Ahlbom A, Albanes D, Andersson U, Freeman L, Buring J, Butler M, Braganza M, Carreon T, Christenssen H, Feychting M, Gapstur S, Gaziano J, Giles G, Hallmans G, Henriksson R, Hoffman-Bolton J, Inskip P, Johansen C, Kitahara C, Liu C, Marchand L, Linet M, Lonn S, Peters U, Purdue M, Rothman N, Ruder A, Sesso1 H, Severi G, Shu X, Stampfer M, Stevens V, Visvanathan K, White E, Willett W, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Decker P, Fridley B, Kosel M, Lachance D, Lau C, Rice T, Wiemels J, Wiencke J, Shete S, Xiao Y, Hoover R, Fraumeni J, Chatterjee N, Hartge P, Chanock S. Genome-wide association study of glioma and meta-analysis. Human Genetics 131(12):1877-1888, 2012. PMCID: PMC3761216.
139. Vidrine J, Shete S, Li Y, Cao Y, Hillard M, Galindo M, Rabius V, Sharp B, Harmonson P, Zbikowski S, Miles L, Wetter D. The ask-advise-connect approach for smokers in a safety net healthcare system: a group-randomized trial. American Journal of Preventive Medicine 45(6):737-741, 2013. PMCID: PMCPMC Journal - In Process.
140. Hutter CM, Mechanic LE, Chatterjee N, Kraft P, Gillanders EM; NCI Gene-Environment Think Tank. Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. Genetic Epidemiology 37(7):643-657, 2013. PMID: 24123198.
141. Sadetzki S, Bruchim R, Oberman B, Armstrong G, Lau C, Claus E, Barnholtz-Sloan J, Ilyasova D, Schildkraut J, Johansen C, Houlston R, Shete S, Amos C, Berstein J, Olson S, Jenkins R, Lachance D, Vick N, Merrell R, Wrensch M, Davis F, McCarthy B, Lai R, TheGliogene Consortium, Melin B, Bondy M. Description of selected characteristics of familial glioma patients-Results from Gliogene Consortium. European Journal of Cancer 49(6):1335-1345, 2013. PMCID: PMC3615132.
142. Wilkinson A, Gabriel K, Bondy M, Dong Q, Shete S, Spitz M. Sensation seeking genes and physical activity in youth. Genes, Brain and Behavior 12(2):181-188, 2013. PMCID: PMC3581711.
143. Vidrine J, Shete S, Cao Y, Greisenger A, Harmonson P, Sharp B, Miles L, Zbikowski S, Wetter D. Ask Advise Connect: A New Approach to Smoking Treatment Delivery in Healthcare Settings. JAMA Internal Medicine 173(6):458-464, 2013. PMCID: PMC3858085.
144. Wu C, Shete S, Jo E, Lu Y, Xu Y, Chen W, Amos C. Whole-genome detection of disease-associated deletions or excess homozygosity in a case-control study of Rheumatoid Arthritis. Human Molecular Genetics 22(6):1249–1261, 2013. PMCID: PMC3578409.
145. Swartz M, Peterson C, Lupo P, Wu X, Forman M, Spitz M, Hernandez L, Vannucci M, Shete S. Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. PLoS ONE 8(1):e53475, 1/2013. PMCID: PMC3553105.
146. Wilkinson A, Swartz M, Yu X, Spitz M, Shete S. Cigarette experimentation and the population attributable fraction for associated genetic and non-genetic risk factors. PLoS ONE 8(8):e53868, 1/2013. PMCID: PMC3547034.
147. Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct loci in the CHRNA5 CHRNA3 CHRNB4 gene cluster are associated with onset of regular smoking. Genetic Epidemiology 37(8):846-859, 2013. PMCID: PMC3947535.
148. Enciso-Mora V, Hosking F, Kinnersley B, Wang Y, Shete S, Zelenika D, Broderick P, Idbaih A, Delattre J, Hoang-Xuan K, Marie Y, Stefano A, Labussiere M, Armstrong G, Liu Y, Gousias K, Schramm J, Lau C, Hepworth S, Wichmann H, Muller M, Schreiber S, Franke A, Moebus S, Eisele L, Tomlinson I, Lathrop M, Swerdlow A, Simon M, Bondy M, Sanson M, Houlston R. Deciphering the 8q24.21 association for glioma. Human Molecular Genetics 22(11):2293-2302, 2013. PMCID: PMC3652416.
149. Robinson J, Versace F, Lam C, Minnix J, Engelmann J, Cui Y, Karam-Hage M, Shete S, Tomlinson G, Chen T, Wetter D, Green C, Cinciripini P. The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers. Frontiers in Psychiatry 23(4), 2013. PMCID: PMC3779859.
150. Sahu R, Pannu H, Yu R, Shete S, Bricker J, Gupta-Malhotra M. Systemic Hypertension Requiring Treatment in Term and Preterm Children in the Neonatal Intensive Care Unit. The Journal of Pediatrics 163(1):84-88, 2013. PMCID: PMC3675186.
151. Enciso-Mora V, Hosking F, Stefano A, Zelenika D, Shete S, Broderick P, Idbaih A, Delattre J, Hoang-Xuan K, Marie Y, Labussiere M, Alentorn A, Ciccarino P, Rossetto M, Armstrong G, Liu Y, Gousias K, Schramm J, Lau C, Hepworth S, Schoemaker M, Strauch K, Muller-Nurasyid M, Schreiber S, Franke A, Moebus S, Eisele L, Swerdlow A, Simon M, Bondy M, Lathrop M, Sanson M, Houlston R. Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222. British Journal of Cancer 108(10):2178–2185, 2013. PMCID: PMC3670481.
152. Reyes-Gibby C, Wang J, Wu X, Yennurajalingam S, Shete S. Genetic variations in Interleukin-8 and Interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. Journal of Pain and Symptom Management 46(2):161-172, 2013. PMCID: PMC3578112.
153. Talluri R, Shete S. A linkage disequilibrium based approach to select disease associated rare variants. PLoS ONE 8(7):e69226, 2013. PMCID: PMC3708889.
154. Reyes-Gibby C, Swartz M, Yu X, Wu X, Yennurajalingam S, Anderson K, Spitz M, Shete S. Symptom Clusters of Pain, Depressed mood, and Fatigue in Lung Cancer: Assessing the Role of Cytokine Genes. Supportive Care in Cancer 21(11):3117-3125, 2013. PMCID: PMC3923575.
155. Gritz ER, Tripp MK, Peterson SK, Prokhorov AV, Shete S, Urbauer DL, Fellman BM, Lee JE, Gershenwald JE.. Randomized Controlled Trial of a Sun Protection Intervention for Children of Melanoma Survivors. Cancer Epidemiology, Biomarkers, and Prevention 22(10):1813-1824, 2013. PMCID: PMC3929920.
156. Wang J, Yu, R, Shete S. Comparison of multilevel modeling and the family-based association test (FBAT) for identifying genetic variants associated with systolic and diastolic blood pressure using GAW18 simulated data. BMC Proc 8(Suppl 1):S30, 2014.
157. Wang J, Yu R, Shete S. X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escaping of X-inactivation. Genetic Epidemiology 38(6):483-493, 2014.
158. Swartz M, Kim T, Niu J, Yu R, Shete S, Ionita-Laza I. Small sample properties for of rare variant analysis methods. BMC Proc 8(Suppl 1):S13, 2014. PMCID: PMCPMC Journal - In Process.
159. Hobbs C, Chowdhury S, Cleves M, Erickson S, MacLeod S, Shaw G, Shete S, Witte J, Tycko B. Genetic Epidemiology and Nonsyndromic Structural Birth Defects: From Candidate Genes to Epigenetics. JAMA Pediatrics 168(4):371-377, 2014.
160. Wei H, Ke H, Lin J, Shete S, Wood C, Hildebrandt M. MicroRNA target site polymorphisms in the VHL-HIF1α pathway predict renal cell carcinoma risk. Molecular Carcinogenesis 53(1):1-7, 2014.
161. Andersson U, Wibom C, Cederquist K, Aradottir S, Borg A, Armstrong G, Shete S, Lau C, Bainbridge M, Claus E, Barnholtz-Sloan J, Lai R, Il'yasova D, Houlston R, Schildkraut J, Bernstein J, Olson S, Jenkins R, Lachance D, Wrensch M, Davis F, Merrell R, Johansen C, Sadetzki S, Bondy M, Melin B. Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon and breast cancer. Neuro-Oncology. In Press.
162. Talluri R, Shete S. Gaussian graphical models for phenotypes using pedigree data and exploratory analysis using networks with genetic and non-genetic factors in GAW18 data. BMC Proc 8(Suppl 1):S99, 2014.
163. Archer N, Wilkinson A, Ranjit N, Wang J, Zhao H, Swann A, Shete S. Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. Brain and Behavior. In Press.
164. Gupta M, Banker A, Shete S, Hashmi S, Tyson J, Barrett M, Hecht J, Milewicz D, Boerwinkle E. Essential Hypertension vs. Secondary Hypertension Among Children. American Journal of Hypertension. In Press.
165. Talluri R, Wang J, Shete S. Calculation of exact p-values when SNPs are tested using multiple genetic models. BMC Genetics 15(1):10.1186/1471-2156-15-75, 2014.
166. Reyes-Gibby C, Anderson K, Merriman K, Todd K, Shete S, Hanna E. Survival patterns in squamous cell carcinoma of the head and neck: Pain as a an indepdent prognostic factor for survival. Journal of Pain. In Press.
167. Wang Z, Zhu B, Zhang M,..,Shete S,..Amundadottir LT. Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Human Molecular Genetics. In Press.
168. Simpson C, Goldenberg A, Culverhouse R, Daley D, Igo R, Jarvik G, Mandal D, Mascalzoni D, Montgomery C, Pierce B, Plaetke R, Shete S, Goddard K, Stein C. Practical barriers and ethical challenges in genetic data sharing. International Journal of Environmental Research and Public Health 11(8):8383-8398, 2014.
169. Talluri R, Wilkinson A, Spitz M, Shete S. A risk prediction model for smoking experimentation in Mexican American youth. Cancer Epidemiology, Biomarkers & Prevention. In Press.

Invited Articles

1. Reyes-Gibby CC, Wu X, Spitz M, Kurzrock R, Fisch M, Bruera E, Shete S. Molecular Epidemiology, Cancer-related Symptoms, and Cytokines Pathway. Lancet Oncol 9(8):777-785, 8/2008. e-Pub 8/2008. PMCID: PMC3390774.

Editorials

1. Shete S. New Editor and New Direction for Genetic Epidemiology. Genetic Epidemiology 36(1):1-2, 2012.
2. Shete S. Virtual Issue: Design and Analytic Approaches in Sequencing Studies. Genetic Epidemiology. e-Pub 2012.

Book Chapters

1. Peterson C, Swartz M, Shete S, Vannucci M. Bayesian Model Averaging for Genetic Association Studies. In: Advances in Statistical Bioinformatics: Models and Integrative Inference for High-Throughput Data. Ed(s) Do K, Qin Z, Vannucci M. Cambridge University Press: New York, 208-223, 2013.
2. Wang J, Shete S. Testing departure from Hardy-Weinberg proportions. In: Methods of Molecular Biology. 850. Ed(s) Elston RC, Satagopan J, Sun S. Humana Press, 77-102, 2012.

Last updated: 9/2/2014