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Sean E McGuire, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Assistant Professor, Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 1202
Houston, TX 77030

Education & Training

Degree-Granting Education

2004 Baylor College of Medicine, Houston, TX, MD, Medicine
2003 Baylor College of Medicine, Houston, TX, PHD, Molecular & Cellular Biology
1994 Harvard University, Cambridge, MA, BA, Biochemistry

Postgraduate Training

7/2005-6/2009 Clinical Residency, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Christopher Crane, MD
7/2004-6/2005 Clinical Internship, Internal Medicine, The University of Texas Health Science at Houston, Houston, TX, Mark A. Farnie, MD

Board Certifications

2009 American Board of Radiology


Other Appointments/Responsibilities

Member, Department of Molecular & Cellular Biology Standing Examination Committee of the Graduate Program, Baylor College of Medicine, Houston, TX, 7/2011-6/2014
Member, MD/PhD Faculty Operating Committee, Baylor College of Medicine, Houston, TX, 2011-2012

Honors and Awards

2010 Distinguished Young Alumnus Award, Baylor College of Medicine
2004 Donald B. Lindsey Prize, Society for Neuroscience
2004 Larry Sandler Award, Genetics Society of America for Outstanding Ph.D.
2003 Harold Weintraub Award, Fred Hutchinson Cancer Center
1998 John J. Trentin Award for Scholastic Excellence, Baylor College of Medicine
1997 Anthony R. Means Award for Scholastic Excellence, Baylor College of Medicine
1994 B.A. with Honors Biochemistry, Harvard University
1993 Ford Grant for Undergraduate Research in Laboratory of Mark Ptashne, Harvard University
1990 Milken Foundation Award and Invitation to American Academy of Achievement Conference
1990 National Merit Finalist and Scholarship Recipient
1990 Selection to American Delegation to the Wiezman Institutes Summer Science Program
1990 Westinghouse National Science Talent Search Finalist
1989 Stanford Book Prize

Selected Publications

Peer-Reviewed Original Research Articles

1. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE . Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol 29(9):1320-33, 9/2015. e-Pub 7/2015. PMCID: PMC4552434.
2. Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE , Flores ER, Sood AK, Mills GB. Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers. Cancer Cell 26(6):863-79, 12/2014. PMCID: PMC4261159.
3. Wang J, Kudchadker R, Choi S, Pettaway CA, Choi H, Hobbs BD, Occena MC, McGuire SE , Pugh TJ, Hoffman K, Mahmood U, Kuban DA. Local recurrence map to guide target volume delineation after radical prostatectomy. Pract Radiat Oncol 4(6):e239-46, Nov-Dec, 11/2014. e-Pub 4/2014. PMID: 25407875.
4. Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MD, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, Van't Veer LJ, Lopez-Bigas N, Laird PW, Raphael BJ, Ding L, Robertson AG, Byers LA, Mills GB, Weinstein JN, Van Waes C, Chen Z, Collisson EA; [Akbani R, Aldape KD, Baggerly KA, Broom BM, Chin L, Edgerton ME, Hamilton SR, Liang H, Liu Y, Lu Y, McGuire SE, Su X, Verhaak R, Wang W, Wu CJ, Yung WK, Zhang N, Zhang W] Cancer Genome Atlas Research Network*, Benz CC, Perou CM, Stuart JM. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. *Collaborator on behalf of the Cancer Genome Atlas Pan-Cancer Analysis Project. Cell 158(4):929-44, 8/2014. PMCID: PMC4152462.
5. Chapin BF, McGuire SE , Aparicio A. Is treatment of the primary tumor in metastatic prostate cancer justified? Eur Urol 65(6):1067-8, 6/2014. e-Pub 12/2013. PMID: 24411278.
6. Cerne JZ, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE . Protein Kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci 55(4):2130-9, 4/2014. e-Pub 4/2014. PMCID: PMC3979518.
7. Hoffman KE, Voong KR, Pugh TJ, Skinner H, Levy LB, Takiar V, Choi S, Du W, Frank SJ, Johnson J, Kanke J, Kudchadker RJ, Lee AK, Mahmood U, McGuire SE , Kuban DA. Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial. Int J Radiat Oncol Biol Phys 88(5):1074-84, 4/2014. PMID: 24661661.
8. Bian SX, Kuban DA, Levy LB, Oh J, Choi S, McGuire SE , Frank SJ, Mahmood U, Nguyen PL, Pugh TJ, Lee AK, Hoffman KE. The Influence of Age and Comorbidity on the Benefit of Adding Androgen Deprivation to Dose-escalated Radiation in Men With Intermediate-risk Prostate Cancer. Am J Clin Oncol . e-Pub 4/2014. PMID: 24732810.
9. Coarfa C, Pichot C, Jackson A, Tandon A, Amin V, Raghuraman S, Paithankar S, Lee AV, McGuire SE , Milosavljevic A. Analysis of interactions between the epigenome and structural mutability of the genome using genboree workbench tools. BMC Bioinformatics 15(7):1471-2105, 2014. e-Pub 5/2014. PMCID: PMC4110728.
10. Cerne JZ, McGuire SE , Grant SR, Munsell MF, Lee AK, Kudchadker RJ, Choi SL, Mahmood U, Hoffman KE, Pugh TJ, Frank SJ, Kuban DA. Factors associated with improved biochemical response to neoadjuvant androgen deprivation therapy before definitive radiation therapy in prostate cancer patients. *Corresponding Author; Co-first Author. Prostate Cancer Prostatic Dis 16(4):346-51, 12/2013. e-Pub 8/2013. PMID: 23939133.
11. Pugh TJ, Munsell MF, Choi S, Nguyen QN, Mathai B, Zhu XR, Sahoo N, Gillin M, Johnson JL, Amos RA, Dong L, Mahmood U, Kuban DA, Frank SJ, Hoffman KE, McGuire SE , Lee AK. Quality of life and toxicity from passively scattered and spot-scanning proton beam therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 87(5):946-53, 12/2013. e-Pub 10/2013. PMCID: PMC4086944.
12. Weinstein JN, Collison EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM, [Akbani R, Aldape KD, Baggerly KA, Broom BM, Chin L, Edgerton ME, Hamilton SR, Liang H, Liu Y, Lu Y, McGuire SE, Su X, Verhaak R, Wang W, Wu CJ, Yung WK, Zhang N, Zhang W]. Cancer Genome Atlas Research Network*. The Cancer Genome Atlas Pan-Cancer analysis project. *Collaborator on behalf of the Cancer Genome Atlas Pan-Cancer Analysis Project. Nature Genetics 45(10):1113-20, 10/2013. PMCID: PMC3919969.
13. Nguyen QN, Levy LB, Lee AK, Choi S, Frank SJ, Pugh TJ, McGuire SE, Hoffman KE, Kuban DA. Long-term Outcomes For Men With High-Risk Prostate Cancer Treated Definitively With External Beam Radiotherapy With and Without Androgen Deprivation. Cancer 119(18):3265-71, 9/2013. PMID: 23798338.
14. Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE , He B. Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun 434(2):357-62, 5/2013. e-Pub 4/2013. PMCID: PMC3763992.
15. Pugh TJ, Frank SJ, Achim M, Kuban DA, Lee AK, Hoffman KE, McGuire SE , Swanson DA, Kudchadker R, Davis JW. Endorectal magnetic resonance imaging for predicting pathologic T3 disease in Gleason score 7 prostate cancer: Implications for prostate brachytherapy. Brachytherapy 12(3):204-9, May-Jun, 5/2013. e-Pub 6/2012. PMCID: PMC4158734.
16. Castle KO, Hoffman KE, Levy LB, Lee AK, Choi S, Nguyen QN, Frank SJ, Pugh TJ, McGuire SE , Kuban DA. Is Androgen Deprivation Therapy Necessary in All Intermediate-Risk Prostate Cancer Patients Treated in the Dose Escalation Era? Int J Radiat Oncol Biol Phys 85(3):693-9, 3/2013. e-Pub 7/2012. PMID: 22836052.
17. McGuire SE , Lee AK, Cerne JZ, Munsell MF, Levy LB, Kudchadker RJ, Choi SL, Nguyen QN, Hoffman KE, Pugh TJ, Frank SJ, Corn PG, Logothetis CJ, Kuban DA. PSA Response to Neoadjuvant Androgen Deprivation Therapy Is a Strong Independent Predictor of Survival in High-Risk Prostate Cancer in the Dose-Escalated Radiation Therapy Era. Int J Radiat Oncol Biol Phys 85(1):e39-46, 1/2013. e-Pub 10/2012. PMCID: PMC3840533.
18. Pair ML, Du W, Rojas HD, Kanke JE, McGuire SE , Lee AK, Kuban DA, Kudchadker RJ. Dosimetric effects of weight loss or gain during volumetric modulated arc therapy and intensity-modulated radiation therapy for prostate cancer. Med Dosim 38(3):251-4, 2013. e-Pub 3/2013. PMID: 23540491.
19. Hamilton MP, Rajapakshe K, Hartig SM, Reva B, McLellan MD, Kandoth C, Ding L, Zack TI, Gunaratne PH, Wheeler DA, Coarfa C, McGuire SE . Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun 4(4):2730, 2013. PMCID: PMC3868236.
20. Bian SX, Kuban DA, Levy LB, Oh J, Castle KO, Pugh TJ, Choi S, McGuire SE , Nguyen QN, Frank SJ, Nguyen PL, Lee AK, Hoffman KE. Addition of short-term androgen deprivation theray to dose-escalated radiation therapy improves failure-free survival for select men with intermediate-risk prostate cancer. Ann Oncol 23(9):2346-52, 9/2012. e-Pub 2/2012. PMID: 22357249.
21. Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE , Marcelli M, Mancini MA. Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. Chem Biol 19(9):1126-41, 9/2012. PMCID: PMC4259876.
22. Cerne JZ, Zong L, Jelinek J, Hilsenbeck SG, Wang T, Oesterreich S, McGuire SE . BRCA1 promoter methylation status does not predict response to tamoxifen in sporadic breast cancer patients. Breast Cancer Res Treat 135(1):135-43, 8/2012. e-Pub 6/2012. PMID: 22706629.
23. Sharp H, Swanson D, Pugh T, Zhang M, Phan J, Kudchadker R, Bruno T, Kuban D, Lee A, Choi S, Nguyen Q, Hoffman K, McGuire SE, Frank S. Screening colonoscopy before prostate cancer treatment can detect colorectal cancers in asymptomatic patients and reduce the rate of complications after brachytherapy. Practical Radiation Oncology 2(3):e7-e13, 7/2012. PMID: 24674130.
24. Kim MM, Hoffman KE, Levy LB, Frank SJ, Pugh TJ, Choi S, Nguyen QN, McGuire SE, Lee AK, Kuban DA. Improvement in prostate cancer survival over time: a 20-year analysis. Cancer J 18(1):1-8, 1/2012. PMID: 22290249.
25. Kim MM, Hoffman KE, Levy LB, Frank SJ, Pugh TJ, Choi S, Nguyen QN, McGuire SE, Lee AK, Kuban DA. Prostate cancer-specific mortality after definitive radiation therapy: Who dies of disease? Eur J Cancer 48(11):1664-71, 2012. e-Pub 2/2012. PMID: 22336663.
26. Hartmaier RJ, Richter AS Gillihan RM, Sallit J, McGuire SE, Wang J, Lee AV, Osborne CK, O’Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae J, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S. A SNP in steroid receptor co-activator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone. Molecular Endocrinology 26(2):220-227, 12/2011. PMCID: PMC3275159.
27. Hartmaier RJ, Tchatchou S, Richter AS, Wang J. McGuire SE Skaar TC, Rae JM. Hemminki K, Sutter C, Ditsch N, Bugert P, Weber BH, Niederacher D, Arnold N, Varon-Mateeva R, Wappenschmidt B, Schmutzler RK, Meindl A, Bartram CR, Burwinkel B, Oesterreich S. Nuclear receptor coregulator SNP discovery and impact on breast cancer risk. BMC Cancer(9):438, 2009. PMCID: PMC2804710.
28. McGuire SE, McGuire AL. Don't throw the baby out with the bathwater: enabling a bottom-up approach in genome-wide association studies. Genome Res 18(11):1683-5, 11/2008. PMCID: PMC3960009.
29. McGuire SE, Frank SJ, Eifel PJ. Treatment of recurrent vaginal melanoma with external beam radiation therapy and palladium-103 brachytherapy. Brachytherapy 7(4):359-63, Oct-Dec, 10/2008. PMID: 18778972.
30. Zhang X, Zhao KL, Guerrero TM, McGuire SE, Yaremko B, Komaki R, Cox JD, Hui Z, Li Y, Newhauser WD, Mohan R, Liao Z. Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer. Int J Radiat Oncol Biol Phys 72(1):278-87, 9/2008. PMCID: PMC2610812.
31. Peintinger F, Kuerer HM, McGuire SE, Bassett R, Pusztai L, Symmans WF. Residual specimen cellularity after neoadjuvant chemotherapy for breast cancer. Br J Surg 95(4):433-7, 4/2008. PMID: 18161887.
32. Dawood S, Broglio K, Kau SW, Islam R, Symmans WF, Buchholz TA, McGuire SE, Meric-Bernstam F, Cristofanilli M, Hortobágyi GN, Gonzalez-Angulo AM. Prognostic value of initial clinical disease stage after achieving pathological complete response. Oncologist 13(1):6-15, 1/2008. PMID: 18245008.
33. McGuire AL, Cho MK, McGuire SE, Caulfield T. The future of personal genomics. Science 317(5845)(1687), 9/2007. PMCID: PMC2220016.
34. McGuire SE, Gonzalez-Angulo AM, Huang EH, Tucker SL, Kau SW, Yu TK, Strom EA, Oh JL, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin AA, Hortobagyi GN, Buchholz TA. Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 68(4):1004-9, 7/2007. e-Pub 4/2007. PMID: 17418973.
35. Alkhatib AA, McGuire SE. Photo Quiz. Sine waves. Neth J Med 65(4):153, 155, 4/2007. PMID: 17452766.
36. Gonzalez-Angulo AM, McGuire SE, Buchholz TA, Tucker SL, Kuerer HM, Rouzier R, Kau SW, Huang EH, Morandi P, Ocana A, Cristofanilli M, Valero V, Buzdar AU, Hortobagyi GN. Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy. J Clin Oncol 23(28):7098-104, 10/2005. PMID: 16192593.
37. McGuire SE, Deshazer M, Davis RL. Thirty years of olfactory learning and memory research in drosophila melanogaster. Prog Neurobiol 76(8):328-47, 8/2005. e-Pub 11/2005. PMID: 16266778.
38. McGuire SE, Roman G, Davis RL. Gene expression systems in drosophila: a synthesis of time and space. Trends Genet 20(8):384-91, 8/2004. PMID: 15262411.
39. McGuire SE, Mao Z, Davis RL. Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci STKE 2004(220):pl6, 2/2004. e-Pub 2/2004. PMID: 14970377.
40. McGuire SE, Le PT, Osborn AJ, Matsumoto K, Davis RL. Spatiotemporal rescue of memory dysfunction in Drosophila. Science(302(5651)):1765-8, 12/2003. PMID: 14657498.
41. McGuire SE, Davis RL. Presenilin-1 and memories of the forebrain. Neuron 32(5):763-5, 12/2001. PMID: 11738022.
42. McGuire SE, Le PT, Davis RL. The role of Drosophila mushroom body signaling in olfactory memory. Science 293(5533):1330-3, 8/2001. PMID: 11397912.
43. Lee AV, Weng CN, McGuire SE, Wolf DM, Yee D. Lac repressor inducible gene expression in human breast cancer cells in vitro and in a xenograft tumor. Biotechniques 23(6):1062-8, 12/1997. PMID: 9421637.
44. Yee D, McGuire SE, Brünner N, Kozelsky TW, Allred DC, Chen SH, Woo SL. Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer. Hum Gene Ther 7(10):1251-7, 6/1996. PMID: 8793549.
45. Lehming N, McGuire SE, Brickman JM, Ptashne M. Interactions of a Rel protein with its inhibitor. Proc Natl Acad Sci U S A 92(22):10242-6, 10/1995. PMCID: PMC40772.
46. McGuire SE, Hilsenbeck SG, Figueroa JA, Jackson JG, Yee D. Detection of insulin-like growth factor binding proteins (IGFBPs) by ligand blotting in breast cancer tissues. Cancer Lett 77(1):25-32, 2/1994. PMID: 7512885.
47. McGuire SE, Fuqua SA, Naylor SL, Helin-Davis DA, McGuire WL. Chromosomal assignments of human 27-kDa heat shock protein gene family. Somat Cell Mol Genet 15(2):167-71, 3/1989. PMID: 2538929.


1. Castle KO, Hoffman KE, Levy LB, Lee AK, Choi S, Nguyen GN, Frank SJ, Pugh T, McGuire SE, Kuban DA. Is Androgen Deprivation Therapy Necessary in Intermediate Risk Prostate Cancer Patients Treated in the Dose Escalation Era?. Int J Rad Oncol Biol Phys 81(2):S 40 - S 41, 2011.
2. TJ Pugh, SJ Frank, M Achim, DA Kuban, AK Lee, S Choi, Q Nguyen, K Hoffman, SE McGuire DA Swanson. Prediction of Extraprostatic Extension in Intermediate Risk Prostate Cancer: The Evolving Role of Endorectal MRI. Int J Rad Oncol Biol Phys 81(2):S 398, 2011.
3. Kim MM, Hoffman KE, Levy LB, Frank SJ, Choi S, Nguyen QN, Pugh TJ, McGuire SE, Lee AK, Kuban DA. Prostate Cancer-Specific Mortality After Definitive Radiation Therapy: Who Dies of Disease?. Proceedings of the 2011 Genitourinary Cancers Symposium (#181), 2011.
4. Kim MM, Hoffman KE, Levy LB, Master P, Frank SJ, Choi S, Nguyen QN, McGuire SE Lee AK, Kuban DA. Improvement in Prostate Cancer Outcomes Over Time: A Twenty-Year Analysis. Int J Rad Oncol Phys 78(3):S 191 (#1115) (#1115), 2010. PMID: 23798338.
5. Ludwig MS, Lee AK, McGuire SE, Choi S, Nguyen QN, Frank SJ, Kuban DA. Influence of Prognostic Factors on Duration of Hormone Therapy and Outcomes. Proceedings of the 92nd Annual Meeting of The American Radium Society, 2010.
6. Kuban DA, Noueras-Gonzalez GM, Hamblin L, Lee AK, Coi S, Frank SJ, Nguyen QN, Hoffman KE, McGuire SE, Munsell MF. Preliminary Report of a Randomized Dose Escalation Trial for Prostate Cancer using Hypofractionation. Int J Rad Oncol Phys 78(3):S58 (#124) (#124), 2010.
7. McGuire SE, Levy LB, Settle SH, Choi S, Nguyen QN, Hoffman KE, Frank SJ, Lee AK, Kuban DA. PSA Response to Neoadjuvant Androgen Suppression Therapy Prior to High Dose Radiotherapy Predicts Survival in Clinically Localized High Risk Prostate Cancer. Int J Rad Oncol Phys 78(3):S 124 (#265) (#265), 2010.

Last updated: 10/21/2015