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Seyed Javad M Moghaddam, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Pulmonary Medicine - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

My research is focused on airway inflammation and its role in airway epithelial carcinogenesis. Cigarette smoking is the principal cause of lung carcinogenesis. However, more than ten separate studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the airways and alveoli, have an increased risk of lung cancer compared to smokers with comparable cigarette exposure but without COPD. This suggests a strong link between COPD-related airway inflammation and lung cancer. We have previously shown that COPD-like airway inflammation, but not asthma-like airway inflammation, promotes lung cancer in a K-ras mutant mouse model. We are currently dissecting the mechanism responsible for this phenomenon. This will provide a better understanding of the role of specific inflammatory pathways in lung carcinogenesis, and subsequently allow preclinical testing of the efficacy of anti-inflammatory agents in preventing lung cancer. This would have a major impact on preventing the leading cause of cancer death by providing the basis for rationally directed therapy in patients at high risk for lung cancer development, and patients with early stage tumors.

Education & Training

Degree-Granting Education

1996 Shaheed Beheshti University of Medical Sciences (SBUMS), Tehran, Iran, MD, Medical School

Postgraduate Training

3/2006-5/2007 Research Fellowship, Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
3/2004-3/2006 Research Fellowship, Pulmonary and Critical Care Section, Baylor College of Medicine, Houston, TX
9/2000-12/2003 Research Fellowship, Research Center for Gastroenterology and Liver Diseases (RCGLD), SBUMS, Tehran, Iran
9/1994-2/1996 Internship, Shaheed Beheshti University of Medical Sciences (SBUMS), Tehran, Iran

Selected Publications

Peer-Reviewed Original Research Articles
1. Barta P, Van Pelt C, Men T, Dickey BF, Lotan R, Moghaddam SJ. Enhancement of Lung Tumorigenesis in a Gprc5a Knockout Mouse by Chronic Extrinsic Airway Inflammation. Mol Cancer 11(1). e-Pub 1/2012. PMID: 22239913.
2. Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6 But Not T helper 2 Cytokines Promotes Lung Carcinogenesis. Cancer Prev Res (Phila) 4(1):51-64, 1/2011. e-Pub 11/2010. PMCID: PMC3058282.
3. Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin Inhibits COPD-Like Airway Inflammation and Lung Cancer Progression in Mice. Carcinogenesis. Carcinogenesis 30(11):1949-56, 11/2009. e-Pub 9/30/2009. PMCID: PMC2783007.
4. Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ. Promotion of Lung Carcinogenesis by COPD-Like Airway Inflammation in a K ras Induced Mouse Model. Am J Respir Cell Mol Biol 40(4):443-53 (Cover Art), 4/2009. e-Pub 10/16/2008. PMCID: PMC2660561.
5. Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of Lung Innate Immunity Protects Against Lethal Pneumococcal Pneumonia. Am J Respir Crit Care Med 177(12):1322-30, 6/15/2008. e-Pub 4/3/2008. PMCID: PMC2427056.
6. Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF. Haemophilus influenzae Lysate Induces Aspects of the Chronic Obstructive Pulmonary Disease Phenotype. Am J Respir Cell Mol Biol 38(6):629-38 (Cover), 6/2008. e-Pub 12/20/2007. PMCID: PMC2396243.
7. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM. Pten Inactivation Accelerated Oncogenic K-ras initiated Tumorgigenesis in a Mouse Model of Lung Cancer. Cancer Res 68(4):1119-1127, 2/15/2008. PMCID: PMC2750029.
8. Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. Central Role of Muc5ac Expression in Mucous Metaplasia and Its Regulation by Conserved 5' Elements. Am J Respir Cell Mol Biol 37(3):273-290, 9/2007. e-Pub 4/2007. PMCID: PMC1994232.

Invited Articles
1. Moghaddam SJ, Ochoa CE, Sethi S, Dickey BF. Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease and Lung Cancer. Int J Chron Obstruct Pulmon Dis 6:113-23, 2011. e-Pub 1/2011. PMCID: PMC3048087.

Book Chapters
1. Sharafkhaneh A, Velamuri S, Moghaddam SJ, Badmaev V, Dickey B, Kurie J. Natural Agents for Chemoprevention of Lung Cancer. In: Lung Cancer, Chapter 28. Blackwell: Abingdon, UK, 2008.

Grant & Contract Support

Title: Dissecting the Role of Airway Inflammation in Lung Cancer Promotion
Funding Source: American Cancer Society (ACS)
Role: Principal Investigator
Duration: 7/1/2011 - 6/30/2015
 
Title: Mast Cell Tryptases in Lung Cancer Development and Progression
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Collaborator
Principal Investigator: Roberto Adachi
Duration: 12/1/2010 - 11/30/2013

Last updated: 7/30/2012