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Sheeba K. Thomas, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Lymphoma/Myeloma, Division of Cancer Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2009 UT School of Medicine, Houston, TX, MS, Clinical Research
1999 Boston University, Boston, MA, BA, Medical Sciences
1999 Boston University, Boston, MA, MD, Medicine

Postgraduate Training

7/2002-6/2005 Clinical Fellowship, Medical Oncology and Hematology, University of Texas M.D. Anderson Cancer Center, Houston, TX, Robert A. Wolff, M.D.
6/1999-6/2002 Clinical Residency, Internal Medicine, Temple University Hospital, Philadelphia, PA, Richard S. Eisenstadt, M.D.

Board Certifications

10/2006 American Board of Internal Medicine, Hematology
2005 American Board of Internal Medicine, Medical Oncology
2002 American Board of Internal Medicine, Internal Medicine

Experience/Service

Academic Appointments

Clinical Specialist, Department of Internal Medicine, Division of Internal Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX, 8/2002-6/2005

Institutional Committee Activities

Member, Clinical Ethics Committee, 9/2007-present
Member, Committee on Guidelines for Chemotherapy-induced Nausea and Vomiting, 9/2007-2/2008
Member, Clinical Research Committee, 7/2006-present

Honors and Awards

2004 Young Investigator Award, American Society of Clinical Oncology
2003 Aventis Award, Department of Thoracic Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center
2003 Jesse H. Jones Clinical Research Fellowship Award, University of Texas M.D. Anderson Cancer Center
1999 Bachelor of Arts, magna cum laude, Boston University
1996 Summer Fellowship Grant, American Society of Hematology
1995 Dean's List, Boston University
1994 Golden Key National Honor Society, National Honor Society
1992-1995 University Scholar, Boston University

Professional Memberships

American Society of Clinical Oncology
Member, 2003-present
American Society of Hematology
Member, 2006-present
Harris County Medical Society, Houston, TX
Member, 2007-present
Massachusetts Medical Society, MA
Member, 1995-present
Southwest Oncology Group
Member, 2007-present
Texas Medical Association, TX
Member, 2007-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Thomas SK, Fossella FV, Liu D, Schaerer R, Tsao AS, Kies MS, Pisters KM, Blumenschein GR, Glisson BS, Lee JJ, Herbst RS, Zinner RG. Asian ethnicity as a predictor of response in patients with non-small-cell lung cancer treated with Gefitinib on an expanded access program. Clin Lung Cancer 7(5):326-31, 2006. PMID: 16640804.
2. Yao KC, Burton AW, Suki D, Rhines LD, Villareal H, Hentschel SJ, Fourney Dr, Thomas S, Wang M, Mendel E. Vertebroplasty and kyphoplasty successfully treat painful multiple myeloma related vertebral compression fractures: Experience at a large tertiary cancer center. J Neurosurgery. e-Pub 2007.
3. Popat U, Saliba R, Thandi R, Hosing C, Shpall E, McMannis J, Korbling M, Alousi A, Andersson B, Nieto Y, Kebriaei P, Khouri I, de Lima M, Weber D, Thomas S, Wang M, Jones R, Champlin R, Giralt S. Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma. American Society for Blood and Marrow Transplantation, 2009. e-Pub 2/2009.

Invited Articles
1. Shah JJ, Orlowski RZ, Thomas SK. Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma. Therapeutics and Clinic Risk Management. In Press.
2. Thomas S, Alexanian R. Current treatment strategies for multiple myeloma. Clin Lymphoma Myeloma 7 Suppl 4:S139-44, 2007. PMID: 17562251.
3. Thomas SK, Richards TA, Weber DM. Lenalidomide in multiple myeloma. Best Pract Res Clin Haematol 20(4)(4):717-735, 2007. PMID: 18070715.

Abstracts
1. Koshy S, Herbst RS, Obasaju CK, Fossella FV, Papadimitrakopoulou VA, Blumenschein G, Peeples BO, Gladish G, Hong WK, Zinner RG. A phase II trial of pemetrexed (P) plus carboplatin (C) in patients with advanced non-small-cell lung cancer. JCO 22:7074, 2004.
2. Reiling RB, Wade JL, Govindan R, Wozniak AJ, Hensing TA, Koshy S, Thienelt CD, Natale RB, Belani CP. Clinical benefit with compassionate use Gefitinib (Iressa®) in a subset of non-small-cell lung cancer patients with the bronchoalvealor subtype treated during an expanded access program (EAP). JCO 22(14S):7087, 2004.
3. Tsao AS, Liu D, Koshy S, Herbst R, Lee J, Hong WK, Kies M. Smoking impacts response in NSCLC patients treated with Gefitinib. AACR-JCA Meeting, 2004.
4. Koshy S, Fossella F, Liu D, Schaerer R, Tsao A, Kies M, Pisters K, Lee J, Herbst R, Zinner R. Asian ethnicity as a predictor of response to Gefitinib in non-small cell lung cancer. 11th World Conference on Lung Cancer, 2005.
5. Thomas S, Burton A, Yao K, Villareal H, Fukshansky M, Are M, Suki D, Mendel E, Rhines L, Weber D, Alexanian R. Percutaneous vertebroplasty and/or kyphoplasty is an effective and safe treatment for painful vertebral compression fractures in multiple myeloma (MM). JCO 24(18S):7610, 2006.
6. Wang M, Delasalle K, Thomas S, Giralt S, Alexanian R. Complete remission represents the major surrogate marker of long survival in multiple myeloma. Blood 108(11):123a (abstr 403), 2006.
7. Thomas S, Giralt S, Wang M, Delasalle KB, Gavino M, Rankin K, Alexanian R, Weber DM. Survival outcomes of patients receiving thalidomide-dexamethasone for previously untreated multiple myeloma. Blood 108(11):1019a (abstr 3569), 2006.
8. Richards T, Horowitz S, Temple S, Nguyen C, Thomas S, Wang M, Giralt S, Weber DM. Evaluation of multiple myeloma response by free light chain assay. Haematologica 92(6):205 (abstr PO-1015), 2007.
9. Thomas SK, Delasalle KB, Gavino M, Wang M, Alexanian R, Weber DM. 2-CDA-cyclophosphamide +/- Rituximab for symptomatic Waldenstrom's Macroglobulinemia. Haematologica 92(6):228, (abstr PO-1227), 2007.
10. Wang M, Delasalle K, Thomas S, Qazilbash M, Giralt S, Weber D, Alexanian R. Early transplant is useful for older patients with multiple myeloma. Haematologica 92(6):189 (abstr PO-819), 2007.
11. Delasalle K, Wang M, Thomas S, Weber D, Alexanian R. High response rate with BCD combination for relapsing multiple myeloma. Haematologica 92(6):158 (abstr PO-616), 2007.
12. Vadhan-Raj S, Weber D, Wang M, Giralt S, Alexanian R. Thomas S, Zhou X, Patel P, Bueso-Ramos C, Newman R, Aggarwal B. Curcumin downregulates NF-КB and related genes in patients with multiple myeloma: Results of a phase 1/2 study. Blood 110(11):357a, (abstr 1177), 2007.
13. Wright J, Weber D, Thomas S, Wang M, Alexanian R, Hawkins V, Vadhan-Raj S. Characteristics of patients experiencing thromboembolic events during treatment of multiple myeloma: Aspirin may not be adequate as thromboprophylaxis in patients with multiple risk factors. Blood 110(11):557a, (abstr 1882), 2007.
14. Giralt S, Thandi R, Qazilbash M, Mendoza F, Han E, Hosing C, Wang M, Thomas S, Alexanian R, Champlin R, Weber D. Retrospective comparison of transplant outcomes in patients with multiple myeloma according to induction therapy with thalidomide/dexamethasone (TD) with or without bortezomib (VTD). Blood 110(11):890a, 2007.
15. Thomas SK, Hosing C, Delasalle KB, Gavino M, Popat UR, Qazilbash MH, Giralt S, Weber DM. Success rates of autologous stem cell collection in patients with Waldenstrom's Macroglobulinemia. Blood. Submitted.
16. Rakkhit R, Jooma N, Delasalle K, Gavino M, Dimopoulos M, Thomas S, McLaughlin P, Alexanian R, Weber D. Incidence of transformation to large cell lymphoma and of second malignancies in symptomatic patients with Waldenstrom's Macroglobulinemia (WM) treated with Cladribine (2-CdA) combination induction therapy. Blood 112(3065), 2008. e-Pub 2008.
17. Popat U, Saliba R, Thandi R, Hosing C, Qazilbash M, Anderlini P, Shpall E, McMannis J, Korbling M, Alousi A, Andersson B, Nieto Y, Kebriaei P, Khouri I, Marcos D, Weber DM, Thomas S, Wang M, Jones R, Champlin R, Giralt S. Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma. Blood. e-Pub 2009.
18. Thomas S, Hosing C, Delasalle K, Gavino M, Popat U, Qazilbash M, Giralt S, Weber D, Alexanian R. Success rates of autologous stem cell collection in patients with Waldenstrom Macroglobulinemia. 5th International Workshop on Waldenstrom's Macroglobulinemia. In Press.

Book Chapters
1. Thomas S, Wang M, Weber D. Abnormal serum protein electrophoresis. In: Women's Health. In Press.
2. Thomas S, Richards T, Weber DM. Lenalidomide in relapsed or refractory multiple myeloma. Myeloma therapy: Pursuing the Plasma Cell. In: Myeloma Therapy, Contemporary Hematology series. The Humana Press, Inc. Totowa, NJ. In Press.
3. Thomas S, Richards T, Weber DM. Novel agents for previously untreated multiple myeloma. In: Multiple Myeloma. Ed(s) I. Ghobrial, M.D., K. Anderson, M.D. Informa Healthcare: New York. In Press.

Manuals, Teaching Aids, Other Teaching Publications
1. Thomas S. Multiple Myeloma: Questions and Answers. M.D. Anderson Cancer Center: Houston, 2005.

Grant & Contract Support

Title: Mechanisms of Symptoms of Multiple Myeloma and Its Therapy, Prevention of Treatment Induced Neuropathy in Patients with Multiple Myeloma
Funding Source: PO1 Grant
Role: Co-Investigator
Principal Investigator: Charles Cleeland
Duration: 7/1/2008 - 6/30/2013
 
Title: Database of Patients with Plasma Cell Dyscrasias.
Funding Source: M.D. Anderson Cancer Center-Execution and Control Budget Phase
Role: Principal Investigator
Duration: 12/1/2007 - 12/1/2008
 
Title: Database of Patients with Plasma Cell Dyscrasias
Funding Source: M.D. Anderson Cancer Center, Analysis & Planning Phase
Role: Principal Investigator
Duration: 9/6/2006 - 9/6/2007

Last updated: 5/1/2009