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Shiaw-Yih Lin, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1999 The University of Texas MD Anderson Cancer Center, Houston, TX, PHD, Cancer Biology
1996 State University of New York (SUNY) at Buffalo, Buffalo, NY, MS, Molecular Pharmacology
1987 Kaohsiung Medical College, Kaohsiung, Taiwan, BS, Pharmacy

Postgraduate Training

1/2000-9/2003 Research Fellowship, Baylor College of Medicine, Houston, TX, Dr. Stephen J Elledge

Selected Publications

Peer-Reviewed Original Research Articles
1. Peng G, Yim E-K, Dai H, Jackson A, van der Burgt I, Pan MR, Hu R, Lin S-Y. BRIT1/MCPH1 links chromatin remodeling to DNA damage response. Nature Cell Biology 11(7):865-872, 7/2009. PMCID: PMC2714531.
2. Yim E-K, Peng G, Dai H, Hu R, Li K, Lu Y, Mills G, Meric-Bernstam F, Hennessy B, Craven R, Lin S-Y. Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function. Cancer Cell 15(4):304-314, 4/2009. PMCID: PMC2673492.
3. Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin S-Y. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 10(2):145-57, 8/2006. e-Pub 7/27/2006. PMCID: PMC1557410.
4. Lin S-Y, Rai R, Li K, Xu ZX, Elledge SJ. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A 102(42):15105-9, 10/2005. e-Pub 10/10/2005. PMCID: PMC1257745.
5. Lin, S-Y, Li K, Stewart GS, Elledge SJ. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A 101(17):6484-6489, 2004. e-Pub 4/19/2004. PMCID: PMC404071.
6. Lin S-Y , Elledge SJ. Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase. Cell 113:881-889, 2003.
7. Lin S-Y, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3(9):802-8, 9/2001. PMID: 11533659.
8. Lin S-Y, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A 97(8):4262-6, 4/2000. PMID: 10759547.

Last updated: 11/26/2010