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Stephen Y. Lai, MD, PhD, FACS

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Lai is an Associate Professor in the Department of Head and Neck Surgery at The University of Texas M. D. Anderson Cancer Center and a board-certified head and neck cancer surgeon.  Dr. Lai received his undergraduate degree from Stanford University and his medical and doctorate degrees from The University of California, San Francisco.  He performed his residency at The University of Pennsylvania and completed his fellowship in oncologic head and neck/cranial base surgery at The University of Pittsburgh School of Medicine.  His clinical expertise is in head and neck cancers with a special emphasis on thyroid and parathyroid disease, salivary gland neoplasms, conservation laryngeal surgery and stereotactic radiosurgery.  Dr. Lai takes a multidisciplinary approach to the management of head and neck cancer patients with active participation in cutting-edge treatment protocols.  Dr. Lai has received research awards from the American College of Surgeons, American Head and Neck Society, American Academy of Otolaryngology and The Thyroid Head and Neck Cancer (THANC) Foundation. 

Research Interests

Regulation of head and neck squamous cell carcinoma (HNSCC) invasion and metastasis by the tumor microenvironment

Hypoxia-inducible factor 1 (HIF-1) and erythropoietin (EPO) in HNSCC

microRNA regulation of HNSCC disease progression

Targeted therapies for thyroid cancer

Imaging-based quantifiable biomarkers of tumor response to treatment (e.g., radiation sensitivity/resistance)

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 1445
Houston, TX 77030
Room Number: FCT10.6002
Fax: (713) 794-4662

Education & Training

Degree-Granting Education

1998 University of California, San Francisco, CA, MD, Medical School
1996 University of California, San Francisco, CA, PhD, Biomedical Sciences
1991 Stanford University, Stanford, CA, BA, with distinction, Economics
1991 Stanford University, Stanford, CA, BS, with distinction and honors, Biological Sciences

Postgraduate Training

7/2003-6/2005 Clinical Fellowship, Department of Otorhinolaryngology and Head & Neck Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, Eugene Myers, MD
7/1999-6/2003 Clinical Residency, Department of Otorhinolaryngology and Head & Neck Surgery, University of Pennsylvania, Philadelphia, PA, David W. Kennedy, MD
6/1998-6/1999 Clinical Internship, Department of General Surgery & Otolaryngology, University of Pennsylvania, Philadelphia, PA, Clyde F. Barker, MD

Board Certifications

2004 American Board of Otolaryngology

Experience/Service

Academic Appointments

Assistant Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008-8/2010
Assistant Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008-8/2010

Honors and Awards

2012-present Super Doctors® Texas Rising Stars
2011-present US News & World Report Top Doctors
2010 American Academy of Otolaryngology - Head and Neck Surgery Honor Award
2007-present America's Top Physicians
2007-present Best Doctors in America
2006 Outstanding Contribution to Otolaryngology Resident Education
2004 American Head & Neck Society Byers Award
1998 Alpha Omega Alpha
1991 Phi Beta Kappa

Professional Memberships

American Academy of Otolaryngology - Head and Neck Surgery
CORE Grant Review Committee, Member, 2008-present
Head and Neck Surgery and Oncology Committee, Member, 2002-2008
Member, 1999-present
American Association for Cancer Research
Member, 2003-present
American College of Surgeons
Fellow, 2006-present
American Head and Neck Society
Annual Meeting Program Committee, 2009-2010
Publication Committee, 2006-2011
Research Committee, 2006-2009
Member, 2004-present
American Rhinologic Society
Member, 1998-2005
American Society of Clinical Oncology
Member, 2006-present
Harris County Medical Society, Houston, TX
Member, 2009-present
North American Skull Base Society
Member, 2004-present
Society of University of Otolaryngologists
Member, 2005-present
Texas Medical Association, Austin, TX
Member, 2009-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Gule MK, Chen Y, Sano D, Frederick MJ, Zhou G, Zhao M, Milas ZL, Galer CE, Henderson YC, Jasser SA, Schwartz DL, Bankson JA, Myers JN, Lai SY. Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model. Clin Cancer Res 17(8):2281-91, 1/2011. PMCID: PMC3079006.
2. Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR. Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms. J Clin Oncol 27(8):1235-42, 3/2009. PMCID: PMC2667824.
3. Lai SY, Walvekar RR, Ferris RL. Minimally invasive video-assisted thyroidectomy: expanded indications and oncologic completeness. Head & Neck 30(11):1403-7, 11/2008. PMCID: PMC2751597.
4. Nance MA, Seethala RR, Wang Y, Chiosea SI, Myers EN, Johnson JT, Lai SY. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer 113(8):2082-9, 10/2008. PMCID: PMC2746751.
5. Bennett CL, Silver SM, Djulbegovic B, Samaras AT, Blau CA, Gleason KJ, Barnato SE, Elverman KM, Courtney DM, McKoy JM, Edwards BJ, Tigue CC, Raisch DW, Yarnold PR, Dorr DA, Kuzel TM, Tallman MS, Trifilio SM, West DP, Lai SY, Henke M. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA 299(8):914-24, 2/2008. PMID: 18314434.

Grant & Contract Support

Title: Radio-Photothermal Nanotherapy for Anaplastic Thyroid Cancer
Funding Source: NIH SPORE Developmental Research Award
Role: Co-Principal Investigator
Principal Investigator: Chun Li
Duration: 8/1/2011 - 10/31/2012
 
Title: MicroRNA-ETC* Regulation of Head and Neck Squamous Cell Carcinoma
Funding Source: UTMDACC Institutional Research Grant
Role: Principal Investigator
Duration: 2/1/2011 - 1/31/2012
 
Title: Assessing GSK2256098 Effects on Thyroid Cancer in Vivo
Funding Source: GlaxoSmithKline (GSK)
Role: Principal Investigator
Duration: 9/10/2010 - 11/30/2011
 
Title: Targeting HNSCC Tumor-initiating Cells Through Stat3
Funding Source: NIH SPORE Collaborative Developmental Research Project
Role: Co-Principal Investigator
Principal Investigator: Tweardy, DJ
Duration: 7/26/2010 - 7/31/2011
 
Title: Enhancing Head and Neck Cancer Radiosensitivity Through STAT3 Inhibition
Funding Source: NIH SPORE Career Development Award
Role: Principal Investigator
Duration: 8/1/2009 - 4/30/2011
 
Title: Regulation of Invasion and Metastasis by HIF-1 in Oral Squamous Cell Carcinoma
Funding Source: NIH Mentored Clinical Scientist Development Award
Role: Principal Investigator
Duration: 9/22/2006 - 8/31/2011
 
Title: Erythropoietin Signaling in Head and Neck Squamous Cell Carcinoma
Funding Source: Flight Attendant Medical Research Institute Young Clinical Scientist Award (FAMRI)
Role: Principal Investigator
Duration: 7/1/2005 - 8/31/2011

Last updated: 8/29/2013