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Steven M. Kornblau

Present Title & Affiliation

Primary Appointment

Professor (with tenure), Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1985 U.T. Medical Branch at Galveston, Galveston, TX, MD, Medicine

Experience/Service

Academic Appointments

Associate Professor (with tenure), Blood and Marrow Transplantation, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1/2000-1/2007
Faculty Associate (non-tenured), Department of Hematology, Division of Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1/1991-1/1992

Selected Publications

Peer-Reviewed Original Research Articles
1. Quintás-Cardama A, Kantarjian H, Ravandi F, O'Brien S, Thomas D, Vidal-Senmache G, Wierda W, Kornblau S, Cortes J. Bleeding diathesis in patients with chronic myelogenous leukemia receiving dasatinib therapy. Cancer 115(11):2482-90, 6/2009. PMID: 19280591.
2. Quintas-Cardama A, Kantarjian H, Jones D, Shan J, Borthakur G, Thomas D, Kornblau S, O'Brien S, Cortes J. Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myelogenous leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy. Blood 113(25):6315-21, 6/2009. PMID: 19369233.
3. Neeley ES, Kornblau SM, Coombes KR, Baggerly KA. Variable Slope Normalization of Reverse Phase Protein Arrays. Bioinformatics 25(11). e-Pub 3/2009. PMID: 19336447.
4. Kornblau SM, Tibes R, Qiu Y, Chen W, Kantarjian HM, Andreeff M, Coombes KR, Mills GB. Functional Proteomic Profiling of AML Predicts Response and Survival. Blood 113(1):154-164, 1/2009. PMID: 18840713.
5. Kornblau SM, Aycox PG, Stephens C, McCue LD, Champlin RE, Marini FC. Control of graft-versus-host disease with maintenance of the graft-versus-leukemia effect in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes. Exp Hematol 35(5):842-53, 5/2007. PMID: 17577932.
6. Kornblau SM, Banker DE, Stirewalt D, Shen D, Lemker E, Verstovsek S, Estrov Z, Faderl S, Cortes J, Beran M, Jackson CE, Chen W, Estey E, Appelbaum FR. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study. Blood 109(7):2999-3006, 4/2007. PMID: 17158228.
7. Kornblau SM, Qiu YH, Bekele BN, Cade JS, Zhou X, Harris D, Jackson CE, Estrov Z, Andreeff M. Studying the right cell in acute myelogenous leukemia: dynamic changes of apoptosis and signal transduction pathway protein expression in chemotherapy resistant ex-vivo selected "survivor cells". Cell Cycle 5(23):2769-77, 12/2006. PMID: 17172852.
8. Kornblau SM. The role of apoptosis in the pathogenesis, prognosis, and therapy of hematologic malignancies. Leukemia 12 Suppl 1:S41-6, 9/1998. PMID: 9777895.
9. Kornblau SM, Thall P, Huh YO, Estey E, Andreeff M. Analysis of CD7 expression in acute myelogenous leukemia: martingale residual plots combined with 'optimal' cutpoint analysis reveals absence of prognostic significance. Leukemia 9(10):1735-41, 10/1995. PMID: 7564518.
10. Kornblau SM, Goodacre A, Cabanillas F. Chromosomal abnormalities in adult non-endemic Burkitt's lymphoma and leukemia: 22 new reports and a review of 148 cases from the literature. Hematol Oncol 9(2):63-78, Mar-Apr, 3/1991. PMID: 1869243.

Abstracts
1. Kornblau SM, Qiu YH, Graber D, Chen W, Melendez J, Konopleva M, Faderl S, Andreeff M, Borthakur G, Yao H, Coombes KR. Protein Expression in Acute Myelogenous Leukemia Stem Cells Compared to Bulk AML Cells Using Reverse Phase Proteins Arrays (RPPA). Blood 112(11):881 (#2536), 11/2008.
2. Kornblau SM, Qiu Y, Chen W, Chou P, Blau L, Nashino H, Ravandi F, Andreeff M, Kantarjian H, Neeley S, Ju Z, Zhang N, Coombes KR. Proteomic Profiling of 150 Proteins in 511 Acute Myelogenous Leukemia (AML) Patient Samples Using Reverse Phase Proteins Arrays (RPPA) Reveals Recurrent Proteins Expression Signatures with Prognostic Implications. Blood 112(11):281-282 (#759), 11/2008.
3. Kornblau SM, Qiu Y, Chen W, Liang H, Ravandi F, Coombes KR, Nagarajan L. Expression and Prognostic Impact of Candidate Suppressor Sequence-Specific Single-Stranded DNA Binding Protein (SSBP2) in AML Using Reverse Phase Proteins Arrays (RPPA). Blood 110(11):707a (#2394), 12/2007.
4. Kornblau SM, McCue D, Ku LK, Chen W, Coombes KR. Cytokine Profiling of Acute Meylogenous Leukemia and Myelodysplasia. Blood 108(11):667a (#2355), 2006.
5. Kornblau SM, Xu H, Del Giglio D, Zhang W, Benedict WF, Deisseroth AB. Patterns of expression of the retinoblastoma antioncogene in leukemia. Proceeding American Association Cancer Research 32(309) (#1835), 1991.

Last updated: 9/29/2009